Local projections of layer Vb-to-Va are more effective in lateral than in medial entorhinal cortex

Summary The entorhinal cortex, in particular neurons in layer V, allegedly mediate transfer of information from the hippocampus to the neocortex, underlying long-term memory. Recently, this circuit has been shown to comprise a hippocampal output recipient layer Vb and a cortical projecting layer Va. With the use of in vitro electrophysiology in transgenic mice specific for layer Vb, we assessed the presence of the thus necessary connection from layer Vb-to-Va in the functionally distinct medial (MEC) and lateral (LEC) subdivisions; MEC, particularly its dorsal part, processes allocentric spatial information, whereas the corresponding part of LEC processes information representing elements of episodes. Using identical experimental approaches, we show that connections from layer Vb-to-Va neurons are more effective in LEC compared with dorsal MEC. This indicates that the hippocampal-cortex output circuit is more effective in LEC, suggesting that episodic systems-consolidation may use LEC-derived information more than allocentric spatial information from MEC.