Functional connectivity network of chronic pain in patients with knee osteoarthritis: A resting-state fMRI study
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Abstract
Background: Few studies exist on the functional connection network of key brain regions in the field of the central mechanism of pain management information. Methods: In this study, we aimed to investigate whether chronic pain is connected to abnormal network connectivity. A total of 28 participants with knee osteoarthritis (KOA) and 28 healthy controls were enrolled. Resting-state functional magnetic resonance imaging (rfMRI) was used to measure functional connection (FC) with the anterior cingulate cortex (ACC) as a seed point and degree of centrality (DC) in the brain regions of the two groups. Results: FC values increased in the right precentral gyrus, while DC values increased in the right precentral gyrus and opercular section of inferior frontal gyrus. Conclusions: Our analysis of brain-interconnect patterns suggests that chronic pain may be self-sustaining. Functional connectivity modulated the relationship between multiple dimensions of chronic pain by altering the relevant brain regions over time so that they reorganized and participated in functional remodeling.
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Abstract
Background: Few studies exist on the functional connection network of key brain regions in the field of the central mechanism of pain management information. Methods: In this study, we aimed to investigate whether chronic pain is connected to abnormal network connectivity. A total of 28 participants with knee osteoarthritis (KOA) and 28 healthy controls were enrolled. Resting-state functional magnetic resonance imaging (rfMRI) was used to measure functional connection (FC) with the anterior cingulate cortex (ACC) as a seed point and degree of centrality (DC) in the brain regions of the two groups. Results: FC values increased in the right precentral gyrus, while DC values increased in the right precentral gyrus and opercular section of inferior frontal gyrus. Conclusions: Our analysis of brain-interconnect patterns suggests that chronic pain may be self-sustaining. Functional connectivity modulated the relationship between multiple dimensions of chronic pain by altering the relevant brain regions over time so that they reorganized and participated in functional remodeling.
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Changjun Li, Jianhao Liu, Zhixiong Kou, et al.
Functional connectivity network of chronic pain in patients with knee osteoarthritis: A resting-state fMRI study. Authorea. 06 June 2025.
DOI: https://doi.org/10.22541/au.174918485.58008558/v1
DOI: https://doi.org/10.22541/au.174918485.58008558/v1
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