Apoptosis and proliferative activity in endometrium during peritoneal endometriosis

V A Burlev; В. А. Бурлев; Pavlovich SV; S. V. Pavlovich; Il'yasova NA; N A Il'yasova

doi:10.1007/s10517-006-0128-x

Apoptosis and proliferative activity in endometrium during peritoneal endometriosis

V A Burlev, В. А. Бурлев, Pavlovich SV, S. V. Pavlovich, Il'yasova NA, N A Il'yasova

Bulletin of experimental biology and medicine · 2006 · doi:10.1007/s10517-006-0128-x · PMID:16984097

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This study observed altered protein expression related to apoptosis in the glandular epithelium during the secretory phase of the menstrual cycle in patients with peritoneal endometriosis compared to controls.

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This study compared apoptosis and proliferative activity in glandular epithelium and endometrial stroma from women with peritoneal endometriosis versus reproductive-age women without endometriosis across menstrual cycle stages. The authors assessed differences in apoptosis intensity by examining changed expression of apoptosis-related proteins in the glandular epithelium during the secretory phase, and found that glandular epithelial proliferative activity in the proliferative phase was higher than in the secretory phase. The key caveat is that the findings are based on endometrial tissue protein expression and activity patterns at specific cycle stages rather than direct functional or mechanistic causal testing. This paper is centrally about endometriosis — it specifically investigates apoptosis-related protein changes and proliferation in endometrium during peritoneal endometriosis.

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Abstract

Apoptosis and proliferative activity of the glandular epithelium and endometrial stroma in patients with peritoneal endometriosis and in women of reproductive age without endometriosis were studied at various stages of menstrual cycle. Differences in the intensity of apoptosis were revealed manifesting in changed expression of proteins in the glandular epithelium of patients with endometriosis during the secretory phase of the menstrual cycle compared to normal. Proliferative activity of the glandular epithelium in the proliferative phase was higher than in the secretory phase. Our results suggest that the imbalance between apoptosis proteins in the endometrium plays a role in the pathogenesis of peritoneal endometriosis.

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Abstract

References

L. V. Adamyan and V. I. Kulakov, Endometrioses [in Russian], Moscow (1998). N. N. Belushkina and I. P. Beletskii, Introduction into Molecular Medicine [in Russian], Ed. M.A. Pal’tsev, Moscow (2004), pp. 414–447. W. P. Dmowski, J. Ding, J. Shen, et al., Hum. Reprod., 16, 1802–1808 (2001). H. M. Gebel, D. P. Braun, A. Tambur, et al., Fertil. Steril., 69, 1042–1047 (1998). R. K. Jones, J. N. Bulmer, and R. F. Searle, Hum. Reprod., 10, 3272–3279 (1995). K. Kokawa, T. Shikone, and R. Nakano, J. Clin. Endocrinol. Metab., 81, 4144–4147 (1996). S. Krajewski, M. Krajewska, and J. C. Reed, Cancer Res., 56, 2849–2855 (1996). K. L. Sharpe-Timms, Ann. NY Acad. Sci., 943, 131–147 (2001). X.-J. Tao, R. A. Sayegh, J. L. Tilly, and K. B. Isaacson, Fertil. Steril., 70, 338–343 (1998). X.-J. Tao, K. I. Tilly, D. V. Maravel, et al., J. Clin. Endocrinol. Metab., 82, 2738–2746 (1997). Revised American Fertility Society Classification of Endometriosis: 1985, Fertil. Steril., 43, No. 3, 351–352 (1985). Author information Authors and Affiliations Additional information __________ Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 141, No. 2, pp. 165–168, February, 2006 Rights and permissions About this article Cite this article Burlev, V.A., Pavlovich, S.V. & Il’yasova, N.A. Apoptosis and proliferative activity in endometrium during peritoneal endometriosis. Bull Exp Biol Med 141, 204–207 (2006). https://doi.org/10.1007/s10517-006-0128-x Received: Issue date: DOI: https://doi.org/10.1007/s10517-006-0128-x

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endometriosis

MeSH descriptors

Endometriosis Endometrium Peritoneal Diseases Adult Apoptosis Case-Control Studies Cell Proliferation Endometriosis Endometrium Female Humans Peritoneal Diseases

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