The inflammatory “past” and “present” of endometrial proliferative diseases. A strategy for clinical management

This narrative paper discusses how lifestyle-driven increases in metabolic syndrome are linked to a rise in proliferative endometrial diseases, emphasizing associations among metabolic syndrome, abnormal uterine bleeding (AUB), heavy menstrual bleeding (HMB), and endometrial hyperplasia (EH). It frames the proposed pathogenesis around systemic inflammation from circulating factors and local accumulation of proinflammatory cytokines, including adipocytokines. The authors then outline updated comprehensive management strategies for patients with AUB, HMB, and EH using domestic (2024) and international guidelines, without presenting new experimental data. This paper relates to endometriosis and/or adenomyosis because it focuses on inflammation and abnormal uterine bleeding within endometrial proliferative disorders, a context relevant to endometriosis/adenomyosis through shared inflammatory mechanisms, though it does not explicitly discuss endometriosis or adenomyosis as conditions.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works