Clinical Profile and Referral Pathways in Late Radiation-Associated Dysphagia (Late-RAD): A Consecutive Case Series

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Abstract

Dysphagia as a late side-effect of radiotherapy (RT) for head and neck cancer (HNC) may not manifest until many years post-treatment (1). Insidious deterioration in swallowing function can significantly impact emotional and physical health. Patients may need enteral feeding support and experience chest co-morbidities which can be fatal (2). Not all patients will develop late-RAD and there is variation in the literature regarding actual prevalence due to heterogeneity in study populations and designs (3). There is also a lack of consensus regarding the definition of ‘late’ but growing acknowledgement that a latency period occurs, where swallowing function is stable before a progressive decline is seen (4). Discharge from surveillance at five years post-treatment has been standard in published recommendations (5). However, there is increasing recognition that this should be extended to allow for appropriate monitoring for the development of delayed side effects (6).
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Clinical Profile and Referral Pathways in Late Radiation-Associated Dysphagia (Late-RAD): A Consecutive Case Series | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL Clinical Otolaryngology This is a preprint and has not been peer reviewed. Data may be preliminary. 10 January 2025 V1 Latest version Share on Clinical Profile and Referral Pathways in Late Radiation-Associated Dysphagia (Late-RAD): A Consecutive Case Series Authors : Diane Sellstrom 0000-0002-3570-9648 [email protected] , James O'Hara , Catherine Haighton 0000-0002-8061-0428 , Tracy Finch , and Joanne Patterson Authors Info & Affiliations https://doi.org/10.22541/au.173653745.51569793/v1 Published Clinical Otolaryngology Version of record Peer review timeline 303 views 201 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Dysphagia as a late side-effect of radiotherapy (RT) for head and neck cancer (HNC) may not manifest until many years post-treatment (1). Insidious deterioration in swallowing function can significantly impact emotional and physical health. Patients may need enteral feeding support and experience chest co-morbidities which can be fatal (2). Not all patients will develop late-RAD and there is variation in the literature regarding actual prevalence due to heterogeneity in study populations and designs (3). There is also a lack of consensus regarding the definition of ‘late’ but growing acknowledgement that a latency period occurs, where swallowing function is stable before a progressive decline is seen (4). Discharge from surveillance at five years post-treatment has been standard in published recommendations (5). However, there is increasing recognition that this should be extended to allow for appropriate monitoring for the development of delayed side effects (6). Supplementary Material File (late effects case series final.docx) Download 47.55 KB Information & Authors Information Version history V1 Version 1 10 January 2025 Peer review timeline Published Clinical Otolaryngology Version of Record 16 Apr 2025 Published Copyright This work is licensed under a Non Exclusive No Reuse License. Collection Clinical Otolaryngology Authors Affiliations Diane Sellstrom 0000-0002-3570-9648 [email protected] Newcastle Upon Tyne Hospitals NHS Foundation Trust View all articles by this author James O'Hara Newcastle Upon Tyne Hospitals NHS Foundation Trust View all articles by this author Catherine Haighton 0000-0002-8061-0428 Northumbria University Department of Social Work Education and Community Wellbeing View all articles by this author Tracy Finch Northumbria University Department of Nursing Midwifery and Health View all articles by this author Joanne Patterson University of Liverpool View all articles by this author Metrics & Citations Metrics Article Usage 303 views 201 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Diane Sellstrom, James O'Hara, Catherine Haighton, et al. Clinical Profile and Referral Pathways in Late Radiation-Associated Dysphagia (Late-RAD): A Consecutive Case Series. Authorea . 10 January 2025. DOI: https://doi.org/10.22541/au.173653745.51569793/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . Format Please select one from the list RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks Direct import Tips for downloading citations document.getElementById('citMgrHelpLink').addEventListener('click', function() { popupHelp(this.href); return false; }); $(".js__slcInclude").on("change", function(e){ if ($(this).val() == 'refworks') $('#direct').prop("checked", false); $('#direct').prop("disabled", ($(this).val() == 'refworks')); }); View Options View options PDF View PDF Figures Tables Media Share Share Share article link Copy Link Copied! Copying failed. 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