Synthesis of GnRH and somatostatin cytotoxic drug conjugates

Sabine Schuster
In: Eötvös Loránd Tudományegyetem · 2020 · doi:10.15476/elte.2019.098 · W3160605025
dissertation OA: gold CC0
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Abstract

Histrelin acetateVantas ® , Suprelin LA ® , Glp-His-Trp-Ser-Tyr-D-His(N τ -Bzl)-Leu-Arg-Pro-EA Treatment of hormone dependent prostate cancer, treatment of central precocious puberty in children Leuprolide acetate (Leuprorelin) Lupron ® , Eligard ® Glp-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-EA Treatment of hormone dependent prostate and breast cancer, endometriosis, uterine fibroids, central precocious puberty Nafarelin acetate Synarel ® Glp-His-Trp-Ser-Tyr-D-Nal-Leu-Arg-Pro-Gly-NH2 Treatment of endometriosis, uterine fibroids, central precocious puberty and in in vitro fertilization Triptorelin acetate or pamoate Decapeptyl ® , Gonapeptyl Depot ® Glp-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2 Treatment of hormone dependent prostate and breast cancers, endometriosis, uterine fibroids, central precocious puberty and in in vitro

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endometriosis

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