The clinic pathological and immunohistochemical features of breast carcinomas with signet-ring-cell differentiation

Background: This study investigated the clinicopathological features, immunophenotypic characteristics and differential diagnosis of primary breast carcinomas with signet ring cell differentiation, as well as differences in signet ring-like cell mucin traits. Methods A total of five cases of primary breast cancer with signet ring cell differentiation diagnosed and treated in The First People’s Hospital of Jingmen from January 2016 to December 2021 were collected. HE, immunohistochemical staining and AB-PAS staining were used to analyze. Results Although we have strictly selected all cases of primary breast cancer with signet ring cell differentiation, but there are differences in the arrangement of cells and the grading of nuclei. Immunohistochemical