Ендометріоз, асоційований із безпліддям: інтеракція імуноендокринних порушень (огляд літератури)

G. D. Koval
In: INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine) · 2018 · vol. 14(4) , pp. 383–391 · doi:10.22141/2224-0721.14.4.2018.140194 · W2894914545
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This literature review examines the pathogenesis of endometriosis-associated infertility, highlighting the interplay between immunological and endocrine disturbances that facilitate ectopic endometrial proliferation and infiltration.

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This literature review examines the pathogenesis of endometriosis and its association with infertility, focusing on the interplay between immunoendocrine disorders. The authors analyze publications from PubMed and Medline to highlight that ectopic endometrial growth is driven by a combination of hormonal backgrounds, growth factors, and immune system regulation. Key findings indicate that while the exact mechanisms remain unclear, immune factors are considered leading contributors alongside endocrine and genetic elements in disease development. This paper is centrally about endometriosis — specifically exploring the immunoendocrine interactions underlying endometriosis-associated infertility.

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Abstract

Ендометріоз (ендометріоїдні гетеротопії) — це патологічний процес, при якому в міометрії чи інших органах статевої системи і поза нею виникають вогнища, структура яких характеризується наявністю епітеліальних і стромальних елементів, властивих ендометрію. Патогенез ендометріозу та асоційованого з ним безпліддя вважається нез’ясованим. Однак більшість науковців сходяться на думці, що в будь-якому разі можливість ектопічного зростання ендометрію може бути за двох умов: при здатності ендометрію до проліферації поза межами фізіологічної локалізації з подальшою інфільтрацією в підлеглу тканину (наприклад, строму очеревини) та за наявності особливих умов для його функціонування в середовищі нової локалізації — відповідного гормонального фону та необхідних ростових факторів. Усі ці процеси регулюються при розвитку захворювання. Робота виконувалася шляхом огляду публікації баз даних PubMed, Medline за останні десятиліття.
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Endometriosis associated with infertility: interactions of immunoendocrine violations (literature review) DOI: https://doi.org/10.22141/2224-0721.14.4.2018.140194Keywords: endometriosis, infertility, immune factors, cytokines, immune cells, pathogenesis, reviewAbstract Endometriosis (endometrioid heterotopies) is a pathological process in which in the myometrium or other organs of the reproductive system and out of it, there are focal areas whose structure is characterized by the presence of epithelial and stromal elements with endometrial characteristics. The pathogenesis of endometriosis and associated infertility is unclear. However, most scientists agree that in any case, there is a risk of ectopic growth of the endometrium in two cases: the ability of the endometrium to proliferate outside the limits of physiological localization with subsequent infiltration into the substructure (for example, stroma of the peritoneum), and under specific conditions for its functioning in the environment of new localization — the presence of corresponding hormonal background and the necessary growth factors. All these processes are regulated by the factors of ]immunity that are considered, along with endocrine and genetic, as leading factors in the development of the disease. The work was carried out by reviewing of the publications of PubMed and Medline databases in recent decades. Downloads References Baskakov VP, Tsvelev IuV, Kira EF. Endometrioidnaia bolezn' [Endometriosis disease]. SPb: Izdatel'stvo N-L; 2002. 452 p. (in Russian). Downloads Published How to Cite Issue Section License Copyright (c) 2018 H.D. Koval This work is licensed under a Creative Commons Attribution 4.0 International License.

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