Identifying Neuropsychiatric Disorder Subtypes and Subtype-dependent Variation in Diagnostic Deep Learning Classifier Performance

ABSTRACT Clinicians and developers of deep learning-based neuroimaging clinical decision support systems (CDSS) need to know whether those systems will perform well for specific individuals. However, relatively few methods provide this capability. Identifying neuropsychiatric disorder subtypes for which CDSS may have varying performance could offer a solution. Dynamic functional network connectivity (dFNC) is often used to study disorders and develop neuroimaging classifiers. Unfortunately, few studies have identified neurological disorder subtypes using dFNC. In this study, we present a novel approach with which we identify 4 states of dFNC activity and 4 schizophrenia subtypes based on their time spent in each state. We also show how the performance of an explainable diagnostic deep learning classifier is subtype-dependent. We lastly examine how the dFNC features used by the classifier vary across subtypes. Our study provides a novel approach for subtyping disorders that (1) has implications for future scientific studies and (2) could lead to more reliable CDSS.