Histomorphological changes in endometriosis in a patient treated with ulipristal: A case report

J Bateman, Justin Bateman, Bateman J, Olga Bougie, Bougie O, O. Bougie, Singh S, S Singh, Sukhbir S. Singh, Islam S, S Islam, SM Rashed Ul Islam
Pathology, research and practice · 2016 · vol. 213(1) , pp. 79–81 · doi:10.1016/j.prp.2016.10.010 · PMID:27914766 · W2541427201
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This case report details the histomorphological changes observed in endometriosis after treatment with ulipristal acetate.

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Abstract

BackgroundSelective progesterone receptor modulators have shown efficacy in the treatment of endometriosis, however they are not currently licensed in Canada for this purpose. Their histomorphological effects have been well documented in the endometrium, but not in endometriosis.Case reportThe patient presented with uterine fibroids and heavy menstrual bleeding, and was treated with ulipristal acetate over three 90-day courses. She eventually elected to undergo definitive surgical management. On pathological examination, she was found to have a focus of endometriosis in the para-tubal soft tissue showing a morphology similar to progesterone receptor modulator associated endometrial changes (PAEC).ConclusionsTo our knowledge this is the first reported case of PAEC involving a focus of endometriosis. This case demonstrates histomorphological evidence of the effects of ulipristal acetate on endometriosis, and thus provides evidence of a pharmacological effect.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Leiomyoma Norpregnadienes Uterine Neoplasms Adult Endometriosis Endometriosis Endometrium Endometrium Female Humans Leiomyoma Leiomyoma Norpregnadienes Norpregnadienes Uterine Neoplasms Uterine Neoplasms

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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