Proximal Femur Versus Acetabular Extra-articular Resection of the Hip Joint for Primary Malignant Bone Tumors : A Retrospective Comparative Review of 33 Cases

Proximal Femur Versus Acetabular Extra-articular Resection of the Hip Joint for Primary Malignant Bone Tumors : A Retrospective Comparative Review of 33 Cases | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Proximal Femur Versus Acetabular Extra-articular Resection of the Hip Joint for Primary Malignant Bone Tumors : A Retrospective Comparative Review of 33 Cases Victor Housset, Philippe Anract, Antoine Babinet, Guillaume Auberger, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-917462/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted 6 You are reading this latest preprint version Abstract Introduction Extra-articular resection (EAR) of the hip joint is prone to significant complications and morbidity. Thus, this study evaluates the cumulative incidences and main reasons of reoperation following EAR of primary bone tumors of the hip to determine whether the outcomes are different between EAR of the pelvis and that of the proximal femur. Patients and methods Thirty-three patients presented with a PMBT of the proximal femur or pelvis were included in this study. Among all PMBTs, 58% originated from the pelvis and 42% were from the proximal femur. Twenty patients had chondrosarcomas (61%), 10 had osteosarcomas (30%), and 3 had sarcomas of another histological subtype (9%). Results The mean follow-up was of 76 months (range: 24–220 months). The cumulative probabilities of revision for any reason was 52% (95% confidence interval [CI]: 30%–70%) five years after surgery. The five-year cumulative probabilities of revision were 13% (95% CI: 4%–27%), 24% (95% CI: 10%–42%) and 34% (95% CI: 14%–56%) for mechanical, infectious and tumoral reasons, respectively. The five-year cumulative probabilities of revision for any reason were 78% (95% CI: 37%–94%) and 14% (95% CI: 2%–38%) for the pelvis and proximal femur, respectively ( p = 0.004). Posterior column preservation was significantly associated with more mechanical complications even after adjusting for the resection site ( p = 0.043). Conclusion Half of patients undergoing EAR of the hip joint for PMBT of the proximal femur or acetabulum will require another operation. EAR of the pelvis is associated with significantly worse outcome than EAR of the proximal femur. Cancer Biology Oncology Proximal Femur Acetabular Extra-articular Resection Hip Joint Primary Malignant Bone Tumors Full Text Cite Share Download PDF Status: Under Review Version 1 posted Reviews received at journal 04 Dec, 2021 Reviewers invited by journal 26 Oct, 2021 Editor assigned by journal 24 Oct, 2021 Submission checks completed at journal 23 Oct, 2021 Editor invited by journal 23 Oct, 2021 First submitted to journal 17 Sep, 2021 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-917462","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":59142968,"identity":"f2db4a1b-1080-4cf3-ad85-58a639e3c151","order_by":0,"name":"Victor Housset","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA/UlEQVRIiWNgGAWjYDACZgiVAOXaQBgJBQz8eLQwNiC0JKQlMLCBaAMGyQbc9qBoOQzRwoBHi8Fx5ucPPu5hyOOXSH/84eOP83n88t2JHx4YMEiY49BjcJjNsHHGM4ZiyRk5ZpIzEm4XS7bxbpYAOkxC5gB2LZLNPIzNPAcYEjfcyGFj5km4nbjhGO8GkJY6CRwOQ9KS/vjzn4RzIC2bf4BswaWFnxmuJcFAmiHhAEjLNgn8WtgMZ844IJE4s+eNmWRPWnLizLbcbRYJBhI4tbDxH37w4cMBm8R+dmCI/bCxS+xnPrv55o8KG5xaoABTmoCGUTAKRsEoGAV4AQAgclgkqcDv+AAAAABJRU5ErkJggg==","orcid":"https://orcid.org/0000-0003-4323-9567","institution":"CHU Henri Mondor: Hopital Henri Mondor","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Victor","middleName":"","lastName":"Housset","suffix":""},{"id":59142969,"identity":"26cad083-94a9-44da-8774-882fdab30079","order_by":1,"name":"Philippe Anract","email":"","orcid":"","institution":"Hopital Cochin","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Philippe","middleName":"","lastName":"Anract","suffix":""},{"id":59142970,"identity":"3bef13fb-bc7e-4733-b651-94c49abaa4e1","order_by":2,"name":"Antoine Babinet","email":"","orcid":"","institution":"Hopital Cochin","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Antoine","middleName":"","lastName":"Babinet","suffix":""},{"id":59142971,"identity":"f8f10610-307f-46cf-9504-238951da6e54","order_by":3,"name":"Guillaume Auberger","email":"","orcid":"","institution":"Hospital Group Deaconess Croix Saint Simon: Groupe hospitalier Diaconesses Croix Saint-Simon","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Guillaume","middleName":"","lastName":"Auberger","suffix":""},{"id":59142972,"identity":"c1d00b9a-18c5-4c80-84b0-0d19bd361580","order_by":4,"name":"David Biau","email":"","orcid":"","institution":"Hopital Cochin","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"David","middleName":"","lastName":"Biau","suffix":""}],"badges":[],"createdAt":"2021-09-18 10:49:59","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-917462/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-917462/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":14948864,"identity":"5876b855-3062-402b-aef8-8f60314e6129","added_by":"auto","created_at":"2021-10-27 14:45:33","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1848511,"visible":true,"origin":"","legend":"","description":"","filename":"Maindocumentwjso.pdf","url":"https://assets-eu.researchsquare.com/files/rs-917462/v1_covered.pdf"}],"financialInterests":"","formattedTitle":"\u003cp\u003eProximal Femur Versus Acetabular Extra-articular Resection of the Hip Joint for Primary Malignant Bone Tumors : A Retrospective Comparative Review of 33 Cases\u003c/p\u003e","fulltext":[{"header":"Full Text","content":"This preprint is available for \u003ca href='/article/rs-917462/latest.pdf' target='_blank'\u003edownload as a PDF\u003c/a\u003e."}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":true,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"world-journal-of-surgical-oncology","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"wjso","sideBox":"Learn more about [World Journal of Surgical Oncology](http://wjso.biomedcentral.com)","snPcode":"12957","submissionUrl":"https://submission.nature.com/new-submission/12957/3","title":"World Journal of Surgical Oncology","twitterHandle":"@OncoBioMed","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"BMC/SO AJ","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"Proximal Femur, Acetabular Extra-articular Resection , Hip Joint , Primary Malignant Bone Tumors","lastPublishedDoi":"10.21203/rs.3.rs-917462/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-917462/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eIntroduction \u003c/p\u003e\u003cp\u003eExtra-articular resection (EAR) of the hip joint is prone to significant complications and morbidity. Thus, this study evaluates the cumulative incidences and main reasons of reoperation following EAR of primary bone tumors of the hip to determine whether the outcomes are different between EAR of the pelvis and that of the proximal femur. \u003c/p\u003e\u003cp\u003ePatients and methods \u003c/p\u003e\u003cp\u003eThirty-three patients presented with a PMBT of the proximal femur or pelvis were included in this study. Among all PMBTs, 58% originated from the pelvis and 42% were from the proximal femur. Twenty patients had chondrosarcomas (61%), 10 had osteosarcomas (30%), and 3 had sarcomas of another histological subtype (9%). \u003c/p\u003e\u003cp\u003eResults \u003c/p\u003e\u003cp\u003eThe mean follow-up was of 76 months (range: 24–220 months). The cumulative probabilities of revision for any reason was 52% (95% confidence interval [CI]: 30%–70%) five years after surgery. The five-year cumulative probabilities of revision were 13% (95% CI: 4%–27%), 24% (95% CI: 10%–42%) and 34% (95% CI: 14%–56%) for mechanical, infectious and tumoral reasons, respectively. The five-year cumulative probabilities of revision for any reason were 78% (95% CI:\u0026nbsp;37%–94%) and 14% (95% CI: 2%–38%) for the pelvis and proximal femur, respectively ( p = 0.004). Posterior column preservation was significantly associated with more mechanical complications even after adjusting for the resection site ( p = 0.043). \u003c/p\u003e\u003cp\u003eConclusion \u003c/p\u003e\u003cp\u003eHalf of patients undergoing EAR of the hip joint for PMBT of the proximal femur or acetabulum will require another operation. EAR of the pelvis is associated with significantly worse outcome than EAR of the proximal femur.\u003c/p\u003e","manuscriptTitle":"Proximal Femur Versus Acetabular Extra-articular Resection of the Hip Joint for Primary Malignant Bone Tumors : A Retrospective Comparative Review of 33 Cases","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2021-10-27 14:45:13","doi":"10.21203/rs.3.rs-917462/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"editorInvitedReview","content":"","date":"2021-12-04T21:36:15+00:00","index":0,"fulltext":""},{"type":"reviewersInvited","content":"","date":"2021-10-26T07:36:13+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2021-10-25T01:59:19+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2021-10-23T23:00:00+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2021-10-23T23:00:00+00:00","index":"","fulltext":""},{"type":"submitted","content":"World Journal of Surgical Oncology","date":"2021-09-17T12:07:39+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"world-journal-of-surgical-oncology","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"wjso","sideBox":"Learn more about [World Journal of Surgical Oncology](http://wjso.biomedcentral.com)","snPcode":"12957","submissionUrl":"https://submission.nature.com/new-submission/12957/3","title":"World Journal of Surgical Oncology","twitterHandle":"@OncoBioMed","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"BMC/SO AJ","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"6b7ba492-d81b-470d-8aa8-c211895791ef","owner":[],"postedDate":"October 27th, 2021","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"under-review","subjectAreas":[{"id":8143421,"name":"Cancer Biology"},{"id":8143422,"name":"Oncology"}],"tags":[],"updatedAt":"2022-05-20T20:54:35+00:00","versionOfRecord":[],"versionCreatedAt":"2021-10-27 14:45:13","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-917462","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-917462","identity":"rs-917462","version":["v1"]},"buildId":"-HB7Z8yhvgn0wM9Nzuekk","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}