Assisted reproduction in endometriosis

Review OA: closed CC-BY-NC-4.0
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This paper reviews the role of assisted reproductive technology (ART) in endometriosis-associated infertility, recommending a segmented approach with agonist trigger, freeze all, and deferred embryo transfer for optimal outcomes.

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Abstract

Endometriosis - a disease causing pain and infertility - is encountered in nearly 50% of infertile women. While medical treatment is effective on pain and recurrence of symptoms after surgical excision, it is of no help for treating infertility for which the only options considered are surgery and ART. Surgery enhances the chances of conceiving naturally during the 12-18 ensuing months irrespective of the stage of the disease. Surgery however is of no help when ART is considered, as it does not improve outcome and can only harm the ovarian response to stimulation. Today therefore, ART is commonly the primary option to be considered in women whose infertility is associated with endometriosis and whose ovarian reserve is compromised and/or who are over 35 years of age. When, ART is envisioned it is best to opt for a segmented ART approach with agonist trigger, freeze all and deferred embryo transfer.
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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Infertility, Female Ovarian Diseases Reproductive Techniques, Assisted Reproductive Techniques, Assisted Adult Adult Endometriosis Endometriosis Endometriosis Female Female Humans Humans Infertility, Female Infertility, Female Infertility, Female Ovarian Diseases Ovarian Diseases Ovarian Diseases

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cited by (1)

Cited by (1)

Source provenance

europepmc
last seen: 2026-11-04T06:09:08.831786+00:00
pubmed
last seen: 2026-10-08T21:23:25.915063+00:00
unpaywall
last seen: 2026-09-12T07:21:10.926195+00:00
License: CC-BY-NC-4.0 · commercial use OK · attribution required
Courtesy of the U.S. National Library of Medicine