Is competition the default configuration of cross-sensory interactions?

Is competition the default configuration of cross-sensory interactions? | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL European Journal of Neuroscience This is a preprint and has not been peer reviewed. Data may be preliminary. 31 March 2025 V1 Latest version Share on Is competition the default configuration of cross-sensory interactions? Authors : Melissa Monti 0009-0007-1280-534X [email protected] , Sophie Molholm 0000-0002-0094-4015 , John Foxe 0000-0002-4300-3098 , and CRISTIANO CUPPINI 0000-0002-6529-2599 Authors Info & Affiliations https://doi.org/10.22541/au.174342457.73914776/v1 Published European Journal of Neuroscience Version of record Peer review timeline 319 views 196 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Several theories have been proposed about the default configuration of the brain’s networks underlying unisensory and multisensory processing abilities and the development of multisensory integration during childhood. Recent empirical findings from animal models and behavioral data collected from typically developing (TD) children and children with autism spectrum disorder (ASD), however, are consistent with the idea that in the immature brain, prior to systematic cross-sensory exposures typically encountered in everyday life, that the individual sensory systems interact in a competitive manner. Which neural architecture and mechanisms best describe the brain’s naïve configuration are still unknown. To fill this gap, this study investigates how sensory modalities interact in the young brain by comparing the predictions of two alternative biologically plausible neuro-computational models to empirical data. The neural substrates responsible for the altered development of multisensory integrative processes observed in ASD children are also investigated. Linking the framework suggested by empirical data to a plausible neural implementation, our results challenge the classical notion of cross-sensory brain organization at birth, whereby the various sensory pathways do not initially interact. Instead, we suggest that direct inhibitory interactions between sensory modalities are taking place in the immature brain, and we suggest that these inhibitory interactions play a crucial role in the altered multisensory perceptual abilities of children with autism. Supplementary Material File (manuscript.pdf) Download 1.10 MB Information & Authors Information Version history V1 Version 1 31 March 2025 Peer review timeline Published European Journal of Neuroscience Version of Record 26 Aug 2025 Published Copyright This work is licensed under a Non Exclusive No Reuse License. Collection European Journal of Neuroscience Keywords autism spectrum disorder multisensory integration neurocomputational modeling switch cost typical development Authors Affiliations Melissa Monti 0009-0007-1280-534X [email protected] Universita degli Studi di Bologna View all articles by this author Sophie Molholm 0000-0002-0094-4015 Albert Einstein College of Medicine View all articles by this author John Foxe 0000-0002-4300-3098 University of Rochester School of Medicine and Dentistry View all articles by this author CRISTIANO CUPPINI 0000-0002-6529-2599 Universita degli Studi di Bologna View all articles by this author Metrics & Citations Metrics Article Usage 319 views 196 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Melissa Monti, Sophie Molholm, John Foxe, et al. Is competition the default configuration of cross-sensory interactions?. Authorea . 31 March 2025. 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