Post-GWAS multiomic functional investigation of theTNIP1locus in Alzheimer’s disease implicates mediation throughGPX3

2022 · doi:10.1101/2022.11.04.22277162
preprint OA: gold CC-BY-NC-ND-4.0
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Abstract

The recently reported TNIP1 / GPX3 locus from AD GWAS studies was investigated. Using proteomics and other functional omics data, we identified evidence for a functional mechanism linking variants in this locus to decreased CSF GPX3 levels as AD progresses, suggesting a new potential target for intervention.

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europepmc
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License: CC-BY-NC-ND-4.0