Quantification of mRNA levels of OCT4 and TGF-β receptor I (TGF-β RI) in human endometrial tissues.

Heng-Kien Au (837971), Jui-Hung Chang (837972), Yu-Chih Wu (837973), Yung-Che Kuo (175057), Yu-Hsi Chen (837974), Wei-Chin Lee (837975), Te-Sheng Chang (837976), Pei-Chi Lan (837977), Hung-Chih Kuo (554958), Kha-Liang Lee (837978), Mei-Tsu Lee (837979), Chii-Ruey Tzeng (837980), Yen-Hua Huang (409275)
2015 · doi:10.1371/journal.pone.0145256.g001 · W6885680471
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Researchers quantified OCT4 and TGF-β receptor I mRNA levels in normal, hyperplastic, endometriotic, adenomyosis, and chocolate cyst tissues to compare expression profiles across these conditions.

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This study utilized reverse transcription and quantitative real-time PCR to measure mRNA expression levels of the pluripotency factor OCT4 and TGF-β receptor I in various human endometrial tissues. The analysis compared primary endometriotic stromal cells, adenomyosis samples, and chocolate cysts against normal and hyperplastic endometrium as well as RL95-2 cell lines for normalization. The results demonstrated significantly elevated expression of both OCT4 and TGF-β RI in endometriotic and adenomyotic tissues compared to controls, with statistical significance established via the Mann-Whitney-U test. This paper is centrally about endometriosis and adenomyosis, specifically investigating the molecular upregulation of these markers in ectopic and intrauterine disease states.

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Abstract

Reverse transcription and quantitative real-time PCR were used to quantify the levels of (A)OCT4 and (B)TGF-β RI mRNAs in RL95-2 human endometrial cell lines, primary endometriotic stromal cells, normal endometrium and hyperplastic endometrium (n = 8), adenomyosis (n = 23), and chocolate cysts (n = 24). The RL95-2 cells were used as internal controls for normalization. Results are expressed as mean ± SD. **P < .01, ***P < .001 in comparison with the control group of normal and hyperplastic endometrium tissues. By Mann-Whitney-U test.
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TGF-βI Regulates Cell Migration through Pluripotent Transcription Factor OCT4 in Endometriosis Fig 1 Quantification of mRNA levels of OCT4 and TGF-β receptor I (TGF-β RI) in human endometrial tissues. Reverse transcription and quantitative real-time PCR were used to quantify the levels of (A) OCT4 and (B) TGF-β RI mRNAs in RL95-2 human endometrial cell lines, primary endometriotic stromal cells, normal endometrium and hyperplastic endometrium (n = 8), adenomyosis (n = 23), and chocolate cysts (n = 24). The RL95-2 cells were used as internal controls for normalization. Results are expressed as mean ± SD. **P < .01, ***P < .001 in comparison with the control group of normal and hyperplastic endometrium tissues. By Mann-Whitney-U test.

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