Prolonged survival of rabid mice after treatment with Poly-ICLC Hiltonol®

Despite its 100% lethality and approximately 59,000 human deaths a year, rabies is still in want of an effective treatment. A host of trials has been described aiming at impairing the life cycle of Lyssavirus rabies (RABV), the chief worldwide lyssavirus causing rabies, but with limited success. In this study, mice intranasally inoculated with the CVS strain of RABV were serially treated with 50µg/day of the Poly ICLC Hiltonol® jn MEM showed significantly higher survival time and disease incubation period as compared to control mice that received MEM only. These very preliminary results indicate that Hiltonol® might be an effective drug against rabies that merits wider in vivo investigation.