Single-Fraction Stereotactic Body Radiotherapy for Locally Advanced Pancreatic Cancer Using Total Intravenous Anaesthesia and Optical Surface Guidance as Motion Management: Technique Presentation and Preliminary Results

Background: The aim of this study was to present the technique and preliminary results of efficacy and safety for single-fraction SBRT for LAPC using Total Intravenous Anaesthesia and Optical Surface Guidance as motion management. Methods: Fifty-five patients were treated with SBRT in a single-fraction receiving median BED10 = 128.9 Gy. Forty-two patients received systemic treatment. End points were OS, FFLP, PFS, and toxicity. Actuarial survival analysis and univariate analysis were investigated. Results: Median follow-up was 15 months. Mean OS was 26.7 months. One-year FFLP and 1-year OS were 100% and 90.9%, respectively. Median PFS was 18 months, and 1-year PFS was 85.5%. Thirty-five patients (63.6%) were alive at the time of analysis. No acute/late toxicity > G2/G1 was reported. Conclusions: SBRT for LAPC using Total Intravenous Anaesthesia and Optical Surface Guidance presented as an effective and safe treatment with very low toxicity.