The oncogenic potential of salivary microRNA-93 and microRNA-412-3p in oral lichen planus: A Case-Control Study

The oncogenic potential of salivary microRNA-93 and microRNA-412-3p in oral lichen planus: A Case-Control Study | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research The oncogenic potential of salivary microRNA-93 and microRNA-412-3p in oral lichen planus: A Case-Control Study Moataz ELhefny, Weam Rashwan, Olfat Shaker, Inas Korien This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4433630/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 23 Dec, 2024 Read the published version in BDJ Open → Version 1 posted You are reading this latest preprint version Abstract Background: Oral Lichen Planus is one of the most popular chronic mucocutaneous diseases. It is classified as potentially malignant lesions. Many microRNAs can be used as biological markers for the disease and for its malignant transformation. The aim of the study to measure the expression of microRNA-93 and microRNA-412-3p in Oral Lichen Planus patients, patients diagnosed as Oral Squamous Cell Carcinoma and healthy controls. Methodology: 60 patients were divided into 3 groups; each group contains 20 patients. Group I for Oral Lichen Planus patients, group II for healthy controls and group III for Oral Squamous cell carcinoma patients. All of these patients were chosen from those attending Kasr Al-Einy hospital, Cairo University. After full diagnosis and matching of our eligibility criteria, saliva sample was taken from each patient to measure the concentration of microRNA-93 and microRNA-412-3p. Results: Both microRNA-93 and miceoRNA-412-3p were upregulated in Oral Squamous cell carcinoma patients than Oral Lichen patients than controls and both of them had great sensitivity, specificity and diagnostic accuracy for both Oral Lichen Planus and Oral Squamous cell carcinoma. Conclusion: MicroRNA-93 and micriRNA-412-3p can be used as diagnostic markers and for the oncogenic potential of Oral Lichen Planus Key Words OLP, OSCC, microRNA, miRNA-93, miRNA-412-3p Health sciences/Diseases/Oral diseases Figures Figure 1 Figure 2 Full Text Additional Declarations There is no duality of interest Tables 1 and 2 are available in the Supplementary Files section. Supplementary Files tables.pdf Cite Share Download PDF Status: Published Journal Publication published 23 Dec, 2024 Read the published version in BDJ Open → Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4433630","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research","associatedPublications":[],"authors":[{"id":305905347,"identity":"dba0cd8b-f181-4dc8-9e8d-db20d0342ded","order_by":0,"name":"Moataz 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Study","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"bdj-open","isNatureJournal":false,"hasQc":false,"allowDirectSubmit":false,"externalIdentity":"bdjopen","sideBox":"Learn more about [BDJ Open](http://www.nature.com/bdjopen/)","snPcode":"41405","submissionUrl":"https://mts-bdjopen.nature.com/cgi-bin/main.plex","title":"BDJ Open","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"ejp","reportingPortfolio":"Nature AJ","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"","lastPublishedDoi":"10.21203/rs.3.rs-4433630/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4433630/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground: \u003c/strong\u003eOral Lichen Planus is one of the most popular chronic mucocutaneous diseases. It is classified as potentially malignant lesions. Many microRNAs can be used as biological markers for the disease and for its malignant transformation. The aim of the study to measure the expression of microRNA-93 and microRNA-412-3p in Oral Lichen Planus patients, patients diagnosed as Oral Squamous Cell Carcinoma and healthy controls.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethodology:\u003c/strong\u003e 60 patients were divided into 3 groups; each group contains 20 patients. Group I for Oral Lichen Planus patients, group II for healthy controls and group III for Oral Squamous cell carcinoma patients. All of these patients were chosen from those attending Kasr Al-Einy hospital, Cairo University. After full diagnosis and matching of our eligibility criteria, saliva sample was taken from each patient to measure the concentration of microRNA-93 and microRNA-412-3p. \u003cstrong\u003eResults:\u003c/strong\u003e Both microRNA-93 and miceoRNA-412-3p were upregulated in Oral Squamous cell carcinoma patients than Oral Lichen patients than controls and both of them had great sensitivity, specificity and diagnostic accuracy for both Oral Lichen Planus and Oral Squamous cell carcinoma.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusion: \u003c/strong\u003eMicroRNA-93 and micriRNA-412-3p can be used as diagnostic markers and for the oncogenic potential of Oral Lichen Planus Key Words OLP, OSCC, microRNA, miRNA-93, miRNA-412-3p\u003c/p\u003e","manuscriptTitle":"The oncogenic potential of salivary microRNA-93 and microRNA-412-3p in oral lichen planus: A Case-Control Study","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-06-14 18:42:41","doi":"10.21203/rs.3.rs-4433630/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bdj-open","isNatureJournal":false,"hasQc":false,"allowDirectSubmit":false,"externalIdentity":"bdjopen","sideBox":"Learn more about [BDJ Open](http://www.nature.com/bdjopen/)","snPcode":"41405","submissionUrl":"https://mts-bdjopen.nature.com/cgi-bin/main.plex","title":"BDJ Open","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"ejp","reportingPortfolio":"Nature AJ","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"3110d1e1-5430-425f-96d7-f7047f79bed7","owner":[],"postedDate":"June 14th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[{"id":32307097,"name":"Health sciences/Diseases/Oral diseases"}],"tags":[],"updatedAt":"2024-12-24T08:09:02+00:00","versionOfRecord":{"articleIdentity":"rs-4433630","link":"https://doi.org/10.1038/s41405-024-00278-5","journal":{"identity":"bdj-open","isVorOnly":false,"title":"BDJ Open"},"publishedOn":"2024-12-23 05:00:00","publishedOnDateReadable":"December 23rd, 2024"},"versionCreatedAt":"2024-06-14 18:42:41","video":"","vorDoi":"10.1038/s41405-024-00278-5","vorDoiUrl":"https://doi.org/10.1038/s41405-024-00278-5","workflowStages":[]},"version":"v1","identity":"rs-4433630","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-4433630","identity":"rs-4433630","version":["v1"]},"buildId":"qtupq5eGEP_6zYnWcrvyt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}