One-pot Double Annulations to Confer Diastereoselective Spirooxindole-pyrrolothiazoles
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OA: closed
CC-BY-4.0
Abstract
A novel four-component reaction with pot, atom, step and economic process to synthesize diastereoselective spirooxindole-pyrrolothiazoles through sequential N, S-acetalation of aldehydes with cysteine and decarboxylative [3+2] cycloaddition with olefinic oxindoles. High synthetic efficiency, operational simplification and reaction process economy using EtOH as solvent, and only releasing CO 2 and H 2 O as side products confer this approach favorable in green chemistry metrics analysis.
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Source provenance
- europepmc
- last seen: 2026-05-19T01:45:01.086888+00:00
- unpaywall
- last seen: 2026-05-22T02:00:06.705733+00:00
License: CC-BY-4.0