Appendiceal Endometriosis: Endometrial Spread and/or Metaplasia?

Adriana Handra-Luca, Adriana Handra‐Luca, Handra-Luca A, Ben Romdhane M, Mohamed Ben Romdhane
Reproductive sciences (Thousand Oaks, Calif.) · 2017 · vol. 24(3) , pp. 339–341 · doi:10.1177/1933719116683810 · PMID:28013575 · W2580009281
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-28 ⓘ

This paper reviews appendiceal endometriosis, examining the potential roles of endometrial spread and metaplasia in its development.

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⚙ AI-generated deep summary by claude@2026-07, 2026-07-08 · read from full text ⓘ

This short paper comments on appendiceal endometriosis, considering whether lesions arise via endometrial spread to the appendix and/or through metaplastic transformation. It discusses pathological concepts and prior literature on endometriosis patterns and cellular behaviors, framing appendiceal involvement within broader mechanisms proposed for endometriosis. A key limitation is that the article is not a primary experimental study and instead provides an interpretive synthesis without new population-level data. This paper is centrally about endometriosis — it specifically addresses mechanistic hypotheses for appendiceal endometriosis (endometrial spread and/or metaplasia).

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References Bedaiwy MA, Dahoud W, Skomorovska-Prokvolit Y, et al. Abundance and localization of progesterone receptor isoforms in endometrium in women with and without endometriosis and in peritoneal and ovarian endometriotic implants. Reprod Sci. 2015;22(9):1153–1161. Kasvandik S, Samuel K, Peters M, et al. Deep quantitative proteomics reveals extensive metabolic reprogramming and cancer-like changes of ectopic endometriotic stromal cells. J Proteome Res. 2016;15(2):572–584. Sandoval P, Jiménez-Heffernan JA, Guerra-Azcona G, et al. Mesothelial-to-mesenchymal transition in the pathogenesis of post-surgical peritoneal adhesions. J Pathol. 2016;239(1):48–59. Rosai J. Rosai and Ackerman’s Surgical Pathology. 10th ed. Mosby Elsevier: Philadelphia, PA; 2011. Clement PB, Young RH. Two previously unemphasized features of endometriosis: micronodular stromal endometriosis and endometriosis with stromal elastosis. Int J Surg Pathol. 2000;8(3):223–227. Clement PB, Young RH,. Atlas of Gynecological Surgical Pathology. 1st ed. Saunders: Philadelphia, PA; 2000. Clement PB, Young RH,. Atlas of Gynecological Surgical Pathology. 2nd ed. Saunders: Philadelphia, PA; 2008. Madsen G, Zakar T, Ku CY, Sanborn BM, Smith R, Mesiano S. Prostaglandins differentially modulate progesterone receptor-A and -B expression in human myometrial cells: evidence for prostaglandin-induced functional progesterone withdrawal. J Clin Endocrinol Metab. 2004;89(2):1010–1013. Author information Authors and Affiliations Corresponding author Rights and permissions About this article Cite this article Handra-Luca, A., Romdhane, M.B. Appendiceal Endometriosis: Endometrial Spread and/or Metaplasia?. Reprod. Sci. 24, 339–341 (2017). https://doi.org/10.1177/1933719116683810 Published: Issue date: DOI: https://doi.org/10.1177/1933719116683810

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Female Humans Peritoneum Protein Isoforms Receptors, Progesterone

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References (8)

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