Effect of Daily Lactococcus cremoris spp. Consumption Immobilized in Oat Flakes on Blood and Urine Biomarkers: A Randomized Placebo Controlled Clinical Trial

Background: The development of non-dairy probiotic products is a challenge for the food industry while cereals as probiotic carriers provide the means to incorporate probiotics, prebiotics, and fiber into the human diet. The present study investigated the effects of Lactococcus cremoris spp. immobilized oat flakes on blood and urine biomarkers in a randomized placebo-controlled single-blind clinical trial. Methods: Fifty-four eligible participants were randomized to placebo or probiotic group that consumes 5g of oat flakes daily, tor 12 weeks. Blood and urine samples were collected at the baseline and at the 6th and 12th week of consumption. Glycemic, lipemic, inflammatory, immunological, antioxidant biomarkers and vitamins were analyzed. Results: Compared to the control group, IL-6 (p=0.045) and hs-CRP (p=0.02) were significantly decreased at week 6 and 12 respectively in the intervention group. Conclusions: Lactococcus cremoris spp immobilized on oat flakes seems to improve biomarkers related to human health. However, further studies are required to characterize the probiotic properties of the studied strain.