Direct Phosphorylation of Aldehydes and Alkylation of Ketones: A New Approach to Synthesize of γ-Ketophosphine Oxides
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Abstract
An effective and economical acid-promoted three-component reaction for the construction of C-P and C-C bonds for the synthesis of γ-ketone phosphine oxides was developed. Detailed mechanistic experiments confirmed that the reaction proceeds by phospha-aldol-elimination, in which a benzylic carbocation is generated from the phosphorylation of aldehydes, which then reacts with ketone enolates under acidic conditions.
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- europepmc
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