VEGF and Flk1 expression in eutopic endometrium and ectopic endometrial tissues of adenomyosis patients

Objective: To investigate vascular endothelial growth factor(VEGF) and Flk1 expression in eutopic endometrium and ectopic endometrial tissues of adenomyosis patients.Methods:VEGF and Flk1 expression were detected by SP assay in 98 adenomyosis cases and 44 healthy controls.Results:There was significant difference in VEGF and Flk1 expression between adenomyosis patients and healthy controls(P0.01);Expression of VEGF and FLK-1 in both eutopic and ectopic endometrium of the adenomyosis patients were signficant different from those in healthy controls,significant difference in their expression at proliferative and secretory phase were also observed between the two groups(P0.01).There was correlation between VEGF and FLK-1 positive expression in both eutopic and ectopic endometrium tissues(P0.05 for both).Conclusions:Higher expression of FLK-1 and VEGF in eutopic and ectopic endometrial tissues of adenomyosis patients may play important role in occurrence and development of adenomyosis.