Influence of different dosage regimens of triptorelin on the disease-controlling action in patients with uterine adenomyosis

OBJECTIVE To compare the influence of different dosage regimens of triptorelin on disease-controlling action in patients with uterine adenomyosis.METHODS From Mar.2011 to Jan.2012 in our hospital,78 patients with uterine adenomyosis were selected and randomly divided into two groups: the control group(38 cases)treated with conventional treatment,injected triptorelin once every four weeks;in the observation group(40 cases) extended the delivery time,injected triptorelin once every six weeks,both groups were treated for 24 weeks,the disease control situation of two groups were compared.RESULTS After treatment,the dysmenorrhea score of two groups were significantly better than before treatment,menstrual flow was significantly reduced and the thickness of endometrium was significantly thinner than before treatment,the differences were statistically significant(P0.05),but the difference was not statistically significant between two groups(P0.05);after treatment,the luteinizing hormone(LH),follicle-stimulating hormone(FSH) and estradiol(E2) levels of two groups were significantly lower,compared with before treatment,the differences were statistical significance(P0.05),but the difference was not statistically significant between two groups(P0.05);there were no serious adverse events.CONCLUSION Different dosage regimens of triptorelin for patients with uterine adenomyosis can play a good role in disease control and security,but extending the delivery time can reduce the number of drugs and dosage,it is the first choice of treatment program.