Full text
26,676 characters
· extracted from
preprint-html
· click to expand
Addressing Pain Management in Intrauterine Device Insertion Post-Universal Coverage in British Columbia | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 9 June 2025 V2 Latest version Share on Addressing Pain Management in Intrauterine Device Insertion Post-Universal Coverage in British Columbia Authors : Sara Sunderji 0009-0001-0098-8448 [email protected] , Anahita Seraji , and Victoria Greene 0009-0001-1293-5781 Authors Info & Affiliations https://doi.org/10.22541/au.174890190.04694623/v2 339 views 120 downloads Contents Abstract Introduction Practice and Training Gaps Essential Reforms Training Model Conclusions Acknowledgments References Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Background: Universal contraceptive coverage in British Columbia (2023) has increased access to intrauterine devices (IUDs), yet procedural pain remains a critical barrier, with over 80% of nulliparous individuals reporting moderate to severe pain and 41% indicating deterrence from future use. Methods: We reviewed national guidelines and evaluated international best practices in IUD insertion pain management and training frameworks. Results: Only 52.9% of physicians routinely offer pain control during insertion, with implementation varying due to inadequate training and resource limitations. Discussion: This gap between international guidelines and clinical practice reveals the need for standardized pain management training. Conclusions: We propose a centralized Hybrid Simulation Training framework integrating evidence-based pain management, shared decision-making, and trauma-informed care principles to improve IUD accessibility in British Columbia. Introduction Intrauterine devices (IUDs) are among the most effective contraceptive modalities in reproductive healthcare, recommended as a first-line option for both nulliparous and multiparous individuals, with typical-use failure rates below 1%. 1,2 These devices play a pivotal role in preventing unintended pregnancies and promoting family planning across diverse populations. Beyond their contraceptive function, hormonal IUDs offer substantial non-contraceptive benefits, including marked reductions in menstrual bleeding and dysmenorrhea, management of endometriosis and polycystic ovarian syndrome, and a potential decrease in uterine cancer risk. 3,4,5,6,7,8 These broader applications reinforce the IUD's importance as a multipurpose intervention in contemporary reproductive healthcare. The introduction of universal no-cost prescription contraception in British Columbia in 2023 has expanded access to over 306,000 individuals within twenty months, 24.5% of whom chose IUDs (V. Greene, personal communication, March 3, 2025). This reflects a broader trend, as IUD uptake among contraceptive users in Canada has risen by up to 28% over the past 15 years. 9 However, despite the removal of financial barriers, procedural pain remains a critical deterrent to broader IUD uptake. 10,11 According to one study, over 80% of nulliparous adolescents and young women report moderate to severe pain during IUD insertion, and 41% say the experience would likely deter them from choosing the method again. 10 Furthermore, a recent survey indicated that more than 40% of participants described their pain experience as unacceptable, and often named it as the primary reason for avoiding or discontinuing IUD use. 12 Concerns around IUD insertion are frequently linked to fear, mistrust, and even trauma, particularly when informed consent and pain management are inadequate. 13 Growing evidence demonstrates that IUD insertions can be a painful experience, prompting multiple international health bodies to recommend routine pain management during the procedure. The Centers for Disease Control and Prevention's (CDC) Selected Practice Recommendations for Contraceptive Use (2024) recommend a proactive, patient-centred approach to IUD placement, suggesting the use of local anesthetics, such as lidocaine, to minimize pain and discomfort. 14 The CDC guidelines are adapted from the World Health Organization’s recommendations, underscoring shared priorities of patient comfort and equitable access to services on a global scale. 14 Reviews of international practice further indicate that, although various pharmaceutical options, including local anesthetics and NSAIDs, have been explored, there is no universally accepted protocol for pain management during IUD insertion. 15 The American Academy of Family Physicians supports both pharmacologic approaches, including lidocaine blocks, and non-pharmacologic strategies such as counselling and aromatherapy. 16 Current research, indicating that techniques such as lidocaine paracervical blocks significantly improve patient satisfaction and IUD uptake, helps validate these guidelines and highlight their significance. 17 Unfortunately, however, implementation of standardized pain management remains inconsistent due in part to gaps in provider training and limited resources. 18 Practice and Training Gaps National data underscores the urgent need for standardized training in pain management during IUD insertion. A survey revealed that only 52.9% of physicians routinely offer pain control, with many relying on patient requests rather than proactively addressing pain. 19 Only about 52% of academic family physicians in Canada feel very comfortable performing IUD insertions, and around 50% refer patients elsewhere, concentrating care among a minority of clinicians, many of whom also lack structured training in pain relief. 20 In a multi-centre Ontario survey, 52.9% of physicians who perform IUD insertions reported routinely providing pain control, while 47.1% did not—often due to logistical barriers, beliefs about the necessity of analgesia, or lack of training and education regarding pain control options. 19 Despite this evidence, the Canadian Contraception Consensus developed by the Society of Obstetricians and Gynaecologists of Canada (SOGC), omits pain management from its clinical recommendations. 2 It cites a study suggesting that most patients experience minimal discomfort, yet fails to disclose that 93% of participants of that study received intrauterine lidocaine. 21 This omission misrepresents the evidence and obscures the role of analgesia in patient experience. By downplaying pain, the guideline reinforces a clinical culture that normalizes rather than treats insertion-related discomfort. 18 As Canada’s national authority on reproductive healthcare, the SOGC shapes institutional policy, clinical norms, and provider education. Its failure to include pain relief in IUD protocols implies that physician competency in this area is non-essential. This contributes to inconsistent practices nationwide and a widespread misunderstanding about the necessity of pain management. In British Columbia, there is no standardized training in procedural pain management; clinicians often rely on informal mentorship, outdated self-study, or must pay out of pocket for external workshops. 19 (A. Seraji, personal communication, May 7, 2025; A. Seraji, personal communication, March 31, 2025) Continuing professional development (CPD) frameworks similarly lack mandates for pain management competencies across providers, including nurse practitioners and midwives. 22 These systemic gaps leave many primary care providers with low procedural confidence and limited knowledge of analgesic options, contributing to inequities in care, delays in IUD uptake, and growing patient mistrust. 17,20,23,24 Essential Reforms Deficiencies in IUD insertion pain management require reform of provider training in British Columbia. A standardized education program must include: mandatory IUD insertion competencies for contraceptive providers; evidence-based pain management protocols; and trauma-informed care with shared decision-making. We recommend that IUD insertion training be centralized through a dedicated provincial institute in British Columbia. This would replace the current patchwork of non-standardized educational pathways—including the University of British Columbia’s Continuing Professional Development, clinical preceptorships, and ad hoc training–with a unified, evidence-based program. 25,26,27 Centralizing education in this way would ensure consistency across provider skillsets and institutional protocols. Most importantly, this would create a standardized platform where provincial health authorities, patients, and providers can implement our recommendation to make pain management an essential, mandatory component of all IUD training. In identifying an educational framework for British Columbia’s IUD insertion program, established gynaecologic approaches offer validated solutions. Best practices encompass problem-based learning (PBL) for clinical reasoning, high-fidelity simulation for procedural skills, and video-based instruction for pain management and patient communication. 28,29,30,31 The Hybrid Simulation Training (HST) model effectively integrates these essential elements, providing a comprehensive framework adaptable to our identified requirements for standardized pain management and trauma-informed care. 32 The HST model combines four key components: didactic teaching, video demonstrations, hands-on practice with pelvic models, and simulated patient interactions. Trainees progress through foundational materials before completing OSCE-style assessments to evaluate history-taking, procedural technique, and counselling competencies. Standardized patients are specifically trained to present clinical scenarios and express procedural discomfort, requiring providers to demonstrate both technical proficiency and empathetic communication. Authors using HST for IUD insertions, documented significant improvements in learner knowledge, procedural ability, and counseling skills following HST implementation. 32 Participants consistently rated the approach highly, particularly noting increased confidence and satisfaction with their training. The framework's pedagogical value and adaptability across settings make it well-suited for addressing British Columbia's identified training deficiencies. 33 Training Model Our adaptation of the HST framework integrates three core competencies: pain management, shared decision-making, and trauma-informed care. Drawing from Best Practices for Pain Management During IUD Insertion, the model combines pharmacologic interventions (NSAIDs, lidocaine—topical, intrauterine, and paracervical blocks) with evidence-based behavioral approaches including anxiety management through benzodiazepines, breathing techniques, and environmental modifications. 13 The curriculum embeds a shared decision-making framework throughout training. 34 Through didactic instruction, videos, and structured discussions, providers develop competency in neutral contraceptive counselling and transparent risk-benefit communication. Anticipatory counselling teaches providers to explain procedural steps, validate concerns, and ensure patient control over pacing. Informed by previous studies, the trauma-informed component establishes specific communication strategies that foster trust and safety. 35,36 A second and third study guide the integration of trauma-informed approaches with standard healthcare protocols, and demonstrate how this improves both patient experience and provider confidence. 37,38 Assessment employs previously established standardized patient scenarios and an evaluation framework to measure competency in all three domains. 32,39 Providers must demonstrate proficiency in pain management protocols, shared decision-making, and trauma-informed care to be certified. Conclusions British Columbia's deficiencies in IUD insertion pain management demand urgent reform through standardized provider training. By implementing a centralized HST-based educational framework that integrates evidence-based pain control protocols, shared decision-making practices, and trauma-informed care principles, we can transform current inconsistent practices into a unified standard of care. This comprehensive approach will not only enhance provider competency and patient experience but also maximize the potential of universal contraceptive coverage by removing a significant barrier to IUD uptake among British Columbians. Acknowledgments The authors would like to acknowledge their collaborative work with AccessBC, a campaign that successfully advocated for universal contraceptive coverage in British Columbia and continues to champion improvements in reproductive healthcare delivery, including addressing pain management during IUD insertion. This research builds upon AccessBC's ongoing efforts to ensure equitable access to comprehensive contraceptive care. Finalized on May 31, 2025. References 1. Adeyemi-Fowode OA, Bercaw-Pratt JL. Intrauterine Devices: Effective Contraception with Noncontraceptive Benefits for Adolescents. Journal of Pediatric and Adolescent Gynecology. 2019 Sep;32(5):S2–6. 2. Black A, Guilbert E, Costescu D, Dunn S, Fisher W, Kives S, et al. Canadian Contraception Consensus (Part 3 of 4): Chapter 7 – Intrauterine Contraception. Journal of Obstetrics and Gynaecology Canada. 2016 Feb;38(2):182–222. 3. Bianchi P, Guo SW, Habiba M, Benagiano G. Utility of the Levonorgestrel-Releasing Intrauterine System in the Treatment of Abnormal Uterine Bleeding and Dysmenorrhea: A Narrative Review. JCM. 2022 Oct 1;11(19):5836. 4. Wang J, Deng K, Li L, Dai Y, Sun X. Levonorgestrel-releasing intrauterine system vs. systemic medication or blank control for women with dysmenorrhea: Systematic review and meta-analysis of randomized controlled trials. Front Glob Womens Health. 2022 Nov 2;3:1013921. 5. Bafna BA, Bafna AN. Levonorgestrel intrauterine system in menorrhagia-an effective and acceptable alternative. Int J Reprod Contracept Obstet Gynecol. 2021 Mar 24;10(4):1665. 6. Gibbons T, Georgiou EX, Cheong YC, Wise MR. Levonorgestrel-releasing intrauterine device (LNG-IUD) for symptomatic endometriosis following surgery. Cochrane Gynaecology and Fertility Group, editor. Cochrane Database of Systematic Reviews [Internet]. 2021 Dec 20 [cited 2025 May 16];2021(12). Available from: http://doi.wiley.com/10.1002/14651858.CD005072.pub4 7. Oguz SH, Yildiz BO. An Update on Contraception in Polycystic Ovary Syndrome. Endocrinol Metab. 2021 Apr 30;36(2):296–311. 8. Minalt N, Caldwell A, Yedlicka GM, Joseph S, Robertson SE, Landrum LM, et al. Association between intrauterine device use and endometrial, cervical, and ovarian cancer: an expert review. American Journal of Obstetrics and Gynecology. 2023 Aug;229(2):93–100. 9. Campbell AJ, Claydon VE, Liva S, Cote AT. Changes in Canadian contraceptive choices: results of a national survey on hormonal contraceptive use. BMC Women’s Health. 2025 Mar 29;25(1):147. 10. Callahan DG, Garabedian LF, Harney KF, DiVasta AD. Will it Hurt? The Intrauterine Device Insertion Experience and Long-Term Acceptability Among Adolescents and Young Women. Journal of Pediatric and Adolescent Gynecology. 2019 Dec;32(6):615–21. 11. Dina B, Peipert LJ, Zhao Q, Peipert JF. Anticipated pain as a predictor of discomfort with intrauterine device placement. American Journal of Obstetrics and Gynecology. 2018 Feb;218(2):236.e1-236.e9. 12. Gero A, Elliott S, Baayd J, Cohen S, Simmons RG, Gawron LM. Factors associated with a negative Patient Acceptable Symptom State (PASS) response with intrauterine device placement: A retrospective survey of HER Salt Lake participants. Contraception. 2024 May;133:110385. 13. Bayer LL, Ahuja S, Allen RH, Gold MA, Levine JP, Ngo LL, et al. Best practices for reducing pain associated with intrauterine device placement. American Journal of Obstetrics and Gynecology. 2025 May;232(5):409–21. 14. Curtis KM, Nguyen AT, Tepper NK, Zapata LB, Snyder EM, Hatfield-Timajchy K, et al. U.S. Selected Practice Recommendations for Contraceptive Use, 2024. MMWR Recomm Rep. 2024 Aug 8;73(3):1–77. 15. Rahman M, King C, Saikaly R, Sosa M, Sibaja K, Tran B, et al. Differing Approaches to Pain Management for Intrauterine Device Insertion and Maintenance: A Scoping Review. Cureus [Internet]. 2024 Mar 8 [cited 2025 May 31]; Available from: https://www.cureus.com/articles/229842-differing-approaches-to-pain-management-for-intrauterine-device-insertion-and-maintenance-a-scoping-review 16. Ovsepyan V, Kelsey P, Evensen AE. Practical Recommendations for Minimizing Pain and Anxiety with IUD Insertion. J Am Board Fam Med. 2024 Nov;37(6):1150–5. 17. Akers AY, Steinway C, Sonalkar S, Perriera LK, Schreiber C, Harding J, et al. Reducing Pain During Intrauterine Device Insertion: A Randomized Controlled Trial in Adolescents and Young Women. Obstetrics & Gynecology. 2017 Oct;130(4):795–802. 18. Hartman-Munick SM, Jhe G, Powell A. IUDs and pain control for adolescents and young adults. Current Opinion in Pediatrics [Internet]. 2025 Mar 20 [cited 2025 May 28]; Available from: https://journals.lww.com/10.1097/MOP.0000000000001457 19. Kirubarajan A, Han S, Gryn A, Patel P, Mohmand Z, Morson N, et al. Barriers and facilitators for providing pain control during intrauterine device insertion: a multi-center physician survey. The European Journal of Contraception & Reproductive Health Care. 2025 Apr 22;1–5. 20. Rezaiefar P, Archibald D, Kabir M, Humphrey-Murto S. Challenges in Providing Gynecological Procedures in Primary Care: A Survey of Canadian Academic Family Physicians. Women’s Health Reports. 2025 Jan 1;6(1):102–12. 21. Black A, Guilbert E, Costescu D, Dunn S, Fisher W, Kives S, et al. Canadian Contraception Consensus (Part 3 of 4): Chapter 7 – Intrauterine Contraception. Journal of Obstetrics and Gynaecology Canada. 2016 Feb;38(2):182–222. 22. Akintomide H, Brima N, Sewell RDE, Stephenson JM. Patients’ experiences and providers’ observations on pain during intrauterine device insertion. The European Journal of Contraception & Reproductive Health Care. 2015 Jul 4;20(4):319–26. 23. British Columbia College of Nurses and Midwives. Framework for midwife certification in intrauterine contraception insertion [Internet]. Vancouver: BCCNM; 2023 Apr [cited 2025 May 31]. Available from: https://www.bccnm.ca/Documents/education_program_review/RM_Framework_for_Cert_in_IU_Contraception_Insertion.pdf 24. Fish A, Ellis B, Cooley J, Vaghela A, Golden E, Brooks B. Pain Perceptions and Management in Outpatient Gynecological Procedures: Survey Insights and Future Implications [Internet]. Public Health and Healthcare; 2024 [cited 2025 May 31]. Available from: https://www.preprints.org/manuscript/202408.1341/v1 25. Hutchinson V, Espey E. How Should IUD Placement Pain Be Described and Managed? AMA Journal of Ethics. 2025 Feb 1;27(2):E72-78. 26. Faculty of Medicine – Continuing Professional Development. Implants and IUDs: comparing and inserting long acting reversible contraceptives (LARC) [Internet]. Vancouver: University of British Columbia; 2024 Nov 16 [cited 2025 May 31]. Available from: https://events.ubc.ca/event/ubc-cpd-implants-and-iuds-comparing-and-inserting-long-acting-reversible-contraceptives-larc/ 27. Society of Obstetricians and Gynaecologists of Canada. Intrauterine contraception (IUC) insertion preceptorship [Internet]. Ottawa: SOGC; [cited 2025 May 31]. Available from: https://sogc.org/en/en/rise/Events/event-display.aspx?EventKey=IUC_PRECEP 28. The IUD Women's Clinic. Contact us to book an appointment [Internet]. Langley (BC): The IUD Women's Clinic; [cited 2025 May 31]. Available from: https://www.theiud-clinic.com/contact 29. Li Y, Zhu R. Effect observation of problem-based learning in obstetric and gynecological clinical nursing teaching [Internet]. In Review; 2024 [cited 2025 May 31]. Available from: https://www.researchsquare.com/article/rs-3736601/v1 30. Liu F, Zhang L. The Effect of Situational Simulation Education Teaching Mode on Clinical Obstetrics and Gynecology Specialty Teaching: A Comparative Study. AOGR. 2024 Feb 28;2(1):44–9. 31. Alkatout I, Dhanawat J, Ackermann J, Freytag D, Peters G, Maass N, et al. Video Feedback and Video Modeling in Teaching Laparoscopic Surgery: A Visionary Concept from Kiel. JCM. 2021 Jan 5;10(1):163. 32. Devi B, Khandelwal B, Das M. Comparison of the effectiveness of video-assisted teaching program and traditional demonstration on nursing students learning skills of performing obstetrical palpation. Iranian J Nursing Midwifery Res. 2019;24(2):118. 33. Amerjee A, Akhtar M, Ahmed I, Irfan S. Hybrid simulation training: An effective teaching and learning modality for intrauterine contraceptive device insertion. Educ Health. 2018;31(2):119. 34. Naylor K, Torres K. Does simulation suffice? Teaching procedural skills in undergraduate medical students- observational quasi-experimental study. [Internet]. In Review; 2019 [cited 2025 May 31]. Available from: https://www.researchsquare.com/article/rs-9302/v1 35. Worthington RO, Oyler J, Pincavage A, Baker NA, Saathoff M, Rusiecki J. A Novel Contraception Counseling and Shared Decision-Making Curriculum for Internal Medicine Residents. MedEdPORTAL. 2020 Dec 4;11046. 36. Gore DJ, Prusky M, Solomon CJE, Tracy K, Longcoy J, Rodriguez J, et al. Creation of a Medical Student Training to Improve Comfort Providing Trauma-Informed Care to Sexual Assault Survivors. MedEdPORTAL. 2021 Apr 20;11140. 37. Reeves EA, Humphreys JC. Describing the healthcare experiences and strategies of women survivors of violence. Journal of Clinical Nursing. 2018 Mar;27(5–6):1170–82. 38. Powell C, Dickins K, Stoklosa H. Training US health care professionals on human trafficking: where do we go from here? Medical Education Online. 2017 Jan;22(1):1267980. 39. Green BL, Kaltman S, Frank L, Glennie M, Subramanian A, Fritts-Wilson M, et al. Primary care providers’ experiences with trauma patients: A qualitative study. Psychological Trauma: Theory, Research, Practice, and Policy. 2011 Mar;3(1):37–41. 40. Dichter ME, Teitelman A, Klusaritz H, Maurer DM, Cronholm PF, Doubeni CA. Trauma-Informed Care Training in Family Medicine Residency Programs: Results From a CERA Survey. Fam Med. 2018 Sep 6;50(8):617–22. Information & Authors Information Version history V1 Version 1 02 June 2025 V2 Version 2 09 June 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords british columbia hybrid simulation training intrauterine devices medical education pain management Authors Affiliations Sara Sunderji 0009-0001-0098-8448 [email protected] View all articles by this author Anahita Seraji View all articles by this author Victoria Greene 0009-0001-1293-5781 View all articles by this author Metrics & Citations Metrics Article Usage 339 views 120 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Sara Sunderji, Anahita Seraji, Victoria Greene. Addressing Pain Management in Intrauterine Device Insertion Post-Universal Coverage in British Columbia. Authorea . 09 June 2025. DOI: https://doi.org/10.22541/au.174890190.04694623/v2 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . Format Please select one from the list RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks Direct import Tips for downloading citations document.getElementById('citMgrHelpLink').addEventListener('click', function() { popupHelp(this.href); return false; }); $(".js__slcInclude").on("change", function(e){ if ($(this).val() == 'refworks') $('#direct').prop("checked", false); $('#direct').prop("disabled", ($(this).val() == 'refworks')); }); View Options View options PDF View PDF Figures Tables Media Share Share Share article link Copy Link Copied! Copying failed. Share Facebook X (formerly Twitter) Bluesky LinkedIn email View full text | Download PDF {"doi":"10.22541/au.174890190.04694623/v2","type":"Article"} Now Reading: Share Figures Tables Close figure viewer Back to article Figure title goes here Change zoom level Go to figure location within the article Download figure Toggle share panel Toggle share panel Share Toggle information panel Toggle information panel Go to previous graphic Go to next graphic Go to previous table Go to next table All figures All tables View all material View all material xrefBack.goTo xrefBack.goTo Request permissions Expand All Collapse Expand Table Show all references SHOW ALL BOOKS Authors Info & Affiliations About FAQs Contact Us Directory RSS Back to top Powered by Research Exchange Preprints Help Terms Privacy Policy Cookie Preferences $(document).ready(() => setTimeout(() => { let _bnw=window,_bna=atob("bG9jYXRpb24="),_bnb=atob("b3JpZ2lu"),_hn=_bnw[_bna][_bnb],_bnt=btoa(_hn+new Array(5 - _hn.length % 4).join(" ")); $.get("/resource/lodash?t="+_bnt); },4000)); (function(){function c(){var b=a.contentDocument||a.contentWindow.document;if(b){var d=b.createElement('script');d.innerHTML="window.__CF$cv$params={r:'a0087fb6caba593a',t:'MTc3OTU4NTg0Ng=='};var a=document.createElement('script');a.src='/cdn-cgi/challenge-platform/scripts/jsd/main.js';document.getElementsByTagName('head')[0].appendChild(a);";b.getElementsByTagName('head')[0].appendChild(d)}}if(document.body){var a=document.createElement('iframe');a.height=1;a.width=1;a.style.position='absolute';a.style.top=0;a.style.left=0;a.style.border='none';a.style.visibility='hidden';document.body.appendChild(a);if('loading'!==document.readyState)c();else if(window.addEventListener)document.addEventListener('DOMContentLoaded',c);else{var e=document.onreadystatechange||function(){};document.onreadystatechange=function(b){e(b);'loading'!==document.readyState&&(document.onreadystatechange=e,c())}}}})();
Text is read by the "Ask this paper" AI Q&A widget below.
Extraction quality varies by source — PMC NXML preserves structure
cleanly, OA-HTML may include some navigation residue, and OA-PDF can
have broken hyphenation. The publisher copy
(via DOI)
is the canonical version.