All-In-One Approaches for Triple-Negative Breast Cancer Therapy: Metal-Phenolic Nanoplatform for MR Imaging-Guided Combinational Therapy

Abstract Background Conventional chemotherapy has poor efficacy in triple-negative breast cancer (TNBC) which is highly heterogeneous and aggressive. Imaging-guided therapy is usually combined with diverse treatment modalities, could realize the integration of diagnosis and treatments. Therefore, the primary challenge for combinational therapy is designing proper delivery systems to accomplish multiple synergistic effects. Results Herein, a facile nanoplatform is manufactured to fulfill the all-in-one approaches for TNBC combinational therapy. Fe3+-based metal-phenolic networks (MPNs) with bovine serum albumin (BSA) modification serve as drug delivery carriers to encapsulate bleomycin (BLM), forming BFE NPs@BSA. It is found that BFE NPs@BSA could be further used as photothermal transduction agents and T1-weighted magnetic resonance imaging (MRI) contrast agents. Once internalized into tumor cells, released BLM could cause DNA damage, while Fenton reactions are initiated to produce highly toxic •OH. Upon laser irradiation, BFE NPs@BSA could convert light into heat to achieve synergistic therapeutic effects. Moreover, as T1-weighted MRI contrast agents, BFE NPs@BSA could provide diagnosis and treatment monitoring for individualized precise therapy. Conclusions This strategy provides an all-in-one theranostic nanoplatform for MRI-guided combinational therapy against TNBC.