Sex and Gender Differences in Iron Chelation

Background: /Objectives: In the absence of physiological mechanisms to excrete exceeding iron, the administration of an iron-chelation therapy is necessary. Age and hormones have an impact on the absorption, distribution, metabolism, and excretion of medications used to treat iron excess, resulting in notable sex and gender-related variances. Methods: Here we aimed to review the literature on sex and gender in iron overload assessment and treatment. Results: The development of iron chelators has shown to be a successful therapy for lowering the body's iron levels and averting the tissue damage and organ failure that follows. Numerous studies describe how individual factors can impact the chelation treatment, potentially impact the therapeutic response, and/or result in inadequate chelation or elevated toxicity; however, most of the data do not consider male and female as different group and, particularly, effect of woman hormonal variation were never considered. Conclusions: An effective iron chelation treatment should take into account sex and gender differences.