Single Oral Dose Ibuprofen for Pain Relief in Fractional Curettage under Paracervical Block: A Double-Blind Randomized Controlled Trial

Vipa Charoenniwetnukul, Boonsri Chanrachakul, Yongyoth Herabutya, Nathpong Israngura Na Ayudhya
In: Thai Journal of Obstetrics and Gynaecology · 2003 · vol. 15(1) , pp. 15–20 · W2185561216
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A double-blind trial found that a single oral dose of ibuprofen before fractional curettage under paracervical block did not significantly reduce pain compared to placebo.

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Abstract

Objective To compare the analgesic efficacy of a single oral dose ibuprofen administered prior to fractional curettage under paracervical block with that of placebo in women undergoing fractional curettage. Design Double-blind, randomized controlled trial. Setting Gynaecological Out-patient, Department of Obstetrics and Gynaecology, Ramathibodi Hospital. Intervention The women were randomized to receive either 400 mg ibuprofen (n=70) or placebo(n=70) 30-60 minutes prior to fractional curettage. All women were curetted under paracervical block with 1% lidocaine. Main outcome measure The intensity of pain during and after the procedure measured by the visual analog score. Results The intensity of pain in ibuprofen group was not significant difference from the placebo group over the course of the procedure (P>0.05). There were no serious adverse effect from the procedure. Conclusion Pre-emptive single oral dose ibuprofen for fractional curettage under paracervical block did not relief pain during and after the procedure.

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