Research progress of the pathogenesis of endometriosis

This paper is a review that discusses current research progress on endometriosis pathogenesis, focusing on the hypothesized roles of endometrial stem cells, steroid hormones and their receptors, genetic factors, neovascularization, and inflammatory and immune processes. It synthesizes evidence from multiple studies and highlights related biological findings such as progesterone resistance, altered estrogen/progesterone signaling components, sustained endometrial proliferation, and links between inflammatory pathways and angiogenic factors. The review does not present new original data and offers a high-level synthesis, with an implicit limitation that it reflects the breadth of published literature rather than testing a single defined mechanistic model. Relevance to endometriosis: the paper explicitly centers on endometriosis (EM) and also cites adenomyosis-related findings in the broader estrogen-processing/receptor context, making it directly related to endometriosis pathogenesis.

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