Chronic alcohol-induced brain states limit propagation of direct cortical stimulation

Chronic alcohol-induced brain states limit propagation of direct cortical stimulation | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Chronic alcohol-induced brain states limit propagation of direct cortical stimulation Bettina Habelt, Nasibeh Talebi, Dzmitry Afanasenkau, Cindy Schwarz, and 7 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6211912/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 10 Oct, 2025 Read the published version in Scientific Reports → Version 1 posted 11 You are reading this latest preprint version Abstract The impact of chronic alcohol consumption is evident in disruptions within prefrontal circuitries, resulting in cognitive and behavioral deficits that underlie lost control over drinking. Given the limited efficacy of current pharmacotherapy, we employed multifunctional bioelectronics to investigate the potential of direct electrical brain stimulation to rectify neural impairments in alcohol-dependent rats. Cortical stimulation counteracted the observed deficiencies in event-related brain potentials and neural oscillations following chronic alcohol consumption, particularly strengthening low-beta oscillations related to executive control. Stimulation efficacy thereby correlated with individual drinking patterns. In alcohol-dependent rats, stimulation-related neuroenhancement was spatially confined to the stimulation site, indicative of reduced neural connectivity as confirmed by a computational approach to directed functional connectivity patterns. Such state-dependent factors may contribute to the varying efficacy of brain stimulation observed in patients, ultimately suggesting personalized neuromodulation designs. Health sciences/Medical research/Pre clinical studies Health sciences/Medical research/Translational research Health sciences/Medical research/Biomarkers Health sciences/Medical research/Biomarkers/Prognostic markers Biological sciences/Neuroscience/Diseases of the nervous system/Addiction Full Text Additional Declarations No competing interests reported. Supplementary Files SupplementaryData1.xlsx SupplementaryData2.xlsx SupplementaryData3.xlsx SupplementaryData4.xlsx SupplementaryData5.xlsx SupplementaryData6.xlsx SupplementaryData8.xlsx SupplementaryData9.xlsx SupplementaryData10.xlsx SupplementaryData11.xlsx SupplementaryData13.xlsx SupplementaryData18.xlsx SupplementaryData17.xlsx SupplementaryData16.xlsx SupplementaryData24.xlsx SupplementaryData25.xlsx SupplementaryData19.xlsx SupplementaryData20.xlsx SupplementaryData21.pdf SupplementaryData23.xlsx SupplementaryData15.xlsx SupplementaryData22.pdf Cite Share Download PDF Status: Published Journal Publication published 10 Oct, 2025 Read the published version in Scientific Reports → Version 1 posted Editorial decision: Revision requested 29 Jun, 2025 Reviews received at journal 25 Jun, 2025 Reviewers agreed at journal 18 Jun, 2025 Reviews received at journal 22 May, 2025 Reviewers agreed at journal 28 Apr, 2025 Reviewers agreed at journal 28 Apr, 2025 Reviewers invited by journal 28 Apr, 2025 Editor assigned by journal 28 Apr, 2025 Editor invited by journal 26 Mar, 2025 Submission checks completed at journal 23 Mar, 2025 First submitted to journal 12 Mar, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6211912","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":449537139,"identity":"89072698-e4d4-4da3-b616-371e289fbff2","order_by":0,"name":"Bettina Habelt","email":"","orcid":"","institution":"TU Dresden","correspondingAuthor":false,"prefix":"","firstName":"Bettina","middleName":"","lastName":"Habelt","suffix":""},{"id":449537140,"identity":"458bc13d-ab7d-4360-9a86-e2af2974251b","order_by":1,"name":"Nasibeh Talebi","email":"","orcid":"","institution":"TU Dresden","correspondingAuthor":false,"prefix":"","firstName":"Nasibeh","middleName":"","lastName":"Talebi","suffix":""},{"id":449537141,"identity":"a734a3d4-42bf-4ce2-9a58-0f4ed78d21ee","order_by":2,"name":"Dzmitry Afanasenkau","email":"","orcid":"","institution":"TU Dresden","correspondingAuthor":false,"prefix":"","firstName":"Dzmitry","middleName":"","lastName":"Afanasenkau","suffix":""},{"id":449537142,"identity":"6fd47e38-3eff-4fe0-acff-19be9e87f047","order_by":3,"name":"Cindy Schwarz","email":"","orcid":"","institution":"TU Dresden","correspondingAuthor":false,"prefix":"","firstName":"Cindy","middleName":"","lastName":"Schwarz","suffix":""},{"id":449537143,"identity":"777f6f15-2fd5-4c13-99e4-c39caa65b37d","order_by":4,"name":"Beate Knauer","email":"","orcid":"","institution":"TU Dresden","correspondingAuthor":false,"prefix":"","firstName":"Beate","middleName":"","lastName":"Knauer","suffix":""},{"id":449537144,"identity":"f9d8302c-7734-4b6b-92ad-872c00eaec37","order_by":5,"name":"Marcus W. 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