Blocking TH1/CD47 axis alleviates pancreatic injury in acute pancreatitis by macrophage phagocytosis

Blocking TH1/CD47 axis alleviates pancreatic injury in acute pancreatitis by macrophage phagocytosis | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 21 January 2026 V1 Latest version Share on Blocking TH1/CD47 axis alleviates pancreatic injury in acute pancreatitis by macrophage phagocytosis Authors : Xiaoyi Deng , Yishao He , Xinyi Liu , Liuhui Wang , Bangjie Liu , Xiaowu Dong , Chenchen Yuan 0000-0002-0551-0718 , Weijuan Gong , Guotao Lu , Weiming Xiao , Weiwei Chen , and Qingtian Zhu [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.176901681.10643207/v1 114 views 56 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Background and Purpose Efferocytosis by macrophages, which involves the clearance of apoptotic cells, plays a pivotal role in the pathogenesis of inflammatory diseases such as acute pancreatitis (AP); however, the underlying molecular mechanisms remain incompletely characterized.This study explores the targeted modulation of the THBS1/CD47 axis in the efferocytosis pathway as a potential strategy to attenuate pancreatic necrosis. Experimental Approach The expression of THBS1 in macrophages was assessed using single-cell RNA sequencing and Western blot analysis. The therapeutic potential of THBS1 blockade in aortic perivalvular inflammation (AP) was evaluated through the application of TAX2, a THBS1/CD47-inhibiting peptide. A rheumatoid arthritis (RA) model was employed to validate the conserved regulatory role of THBS1 in inflammatory processes. Key Results In the context of acute pancreatitis (AP), macrophages exhibit a significant upregulation of THBS1. TAX2 enhances macrophage efferocytosis, thereby ameliorating pancreatic injury in AP model mice. The underlying mechanism of THBS1 involves the mediation of macrophage efferocytosis through specific binding to the downstream receptor CD36. Inhibition of THBS1 has been demonstrated to alleviate joint damage in murine models of rheumatoid arthritis (RA). Conclusions and Implications Targeting the THBS1/CD47 axis has substantial clinical implications for the treatment of acute pancreatitis (AP). Supplementary Material File (figure1-8.pdf) Download 4.83 MB File (manuscript.docx) Download 39.11 KB Information & Authors Information Version history V1 Version 1 21 January 2026 Copyright This work is licensed under a Non Exclusive No Reuse License. Authors Affiliations Xiaoyi Deng Affiliated Hospital of Yangzhou University View all articles by this author Yishao He Yangzhou University Medical College View all articles by this author Xinyi Liu Affiliated Hospital of Yangzhou University View all articles by this author Liuhui Wang Affiliated Hospital of Yangzhou University View all articles by this author Bangjie Liu Affiliated Hospital of Yangzhou University View all articles by this author Xiaowu Dong Affiliated Hospital of Yangzhou University View all articles by this author Chenchen Yuan 0000-0002-0551-0718 Affiliated Hospital of Yangzhou University View all articles by this author Weijuan Gong Yangzhou University Medical College View all articles by this author Guotao Lu Affiliated Hospital of Yangzhou University View all articles by this author Weiming Xiao Affiliated Hospital of Yangzhou University View all articles by this author Weiwei Chen Affiliated Hospital of Yangzhou University View all articles by this author Qingtian Zhu [email protected] Affiliated Hospital of Yangzhou University View all articles by this author Metrics & Citations Metrics Article Usage 114 views 56 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Xiaoyi Deng, Yishao He, Xinyi Liu, et al. Blocking TH1/CD47 axis alleviates pancreatic injury in acute pancreatitis by macrophage phagocytosis. Authorea . 21 January 2026. DOI: https://doi.org/10.22541/au.176901681.10643207/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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