Grating-Based Phase-Contrast Breast ComputedTomography at an Inverse Compton Source

Grating-Based Phase-Contrast Breast ComputedTomography at an Inverse Compton Source | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Help Center Sign In Submit a Preprint Cite Share Download PDF Article Grating-Based Phase-Contrast Breast ComputedTomography at an Inverse Compton Source Daniel Berthe, Lisa Heck, Sandra Resch, Martin Dierolf, Johannes Brantl, and 7 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-3891369/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 26 Oct, 2024 Read the published version in Scientific Reports → Version 1 posted 11 You are reading this latest preprint version Abstract The introduction of mammography screening programs has significantly reduced breast cancer mortality rates. Nevertheless, some lesions remain undetected, especially in dense breast tissue. Studies have shown that phase-contrast imaging can improve breast cancer diagnosis by increasing soft tissue contrast. Furthermore, grating-based phase-contrast imaging enables the simultaneous acquisition of absorption-, phase-contrast, and scattering, so-called dark-field images. The latter allows the classification of microcalcifications. In addition, breast computed tomography (BCT) systems can identify and discriminate overlapping but clinically relevant structures. This study investigates the benefit of combining grating-based phase-contrast with BCT. For this task, two Photon counting detector (PCD)s are used, and their performance is compared to a flat panel detector in terms of their resolution. The results demonstrate a resolution advantage of PCDs over flat panel detectors. Furthermore, we explore the potential of grating-based phase-contrast breast computed tomography (gbpc-BCT) with a breast phantom and a freshly dissected fibroadenoma. Improved image contrast could be achieved with radiation doses comparable to those used inclinical mammography. Biological sciences/Cancer/Breast cancer Physical sciences/Optics and photonics/Optical physics/X rays Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Published Journal Publication published 26 Oct, 2024 Read the published version in Scientific Reports → Version 1 posted Editorial decision: Revision requested 05 Jun, 2024 Reviews received at journal 28 May, 2024 Reviewers agreed at journal 16 Apr, 2024 Reviews received at journal 07 Feb, 2024 Reviewers agreed at journal 03 Feb, 2024 Reviewers agreed at journal 28 Jan, 2024 Reviewers invited by journal 27 Jan, 2024 Editor assigned by journal 27 Jan, 2024 Editor invited by journal 27 Jan, 2024 Submission checks completed at journal 27 Jan, 2024 First submitted to journal 23 Jan, 2024 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-3891369","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":270074813,"identity":"13617626-aab8-48e3-9bbe-91516d26d42d","order_by":0,"name":"Daniel Berthe","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA70lEQVRIiWNgGAWjYBACeyA+wFDAUAek2RgYKsCCBni1GDaAtBgwJDMwMAO1nDEgrMXgAERNYgNIC2MbMVqOnz144APQFn7p88cefJz3J3FtA/PGB3i1nMlLODjDgKFOsi+Z3XDmNoPEbQfYivFaY3Agx+AwD9AWgzPMbNK8YC08ZhJ4tZx/Y3D4D9Av+0Fa/s4BazH/gVfLDaAtIO9v4AFqYWyA2IJPB4PhjDcGB3sMJJIlzjCbSfYcMzbedpitGK/D7PlzjD/8qLCp4+9hfCbxo0ZOdtvx5o0f8FoDAcjGMhOhfhSMglEwCkYBfgAAQbpLljbbJOUAAAAASUVORK5CYII=","orcid":"","institution":"Technical University of Munich","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Daniel","middleName":"","lastName":"Berthe","suffix":""},{"id":270074814,"identity":"90ad61fd-c359-4d56-b80f-b652cabd1c92","order_by":1,"name":"Lisa Heck","email":"","orcid":"","institution":"Technical University of Munich","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Lisa","middleName":"","lastName":"Heck","suffix":""},{"id":270074815,"identity":"93ec4476-bf99-48cf-8e61-3fd841d6dd79","order_by":2,"name":"Sandra Resch","email":"","orcid":"","institution":"Technical University of Munich","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Sandra","middleName":"","lastName":"Resch","suffix":""},{"id":270074816,"identity":"8a211961-3bb6-45df-b71f-2fb930fe0399","order_by":3,"name":"Martin Dierolf","email":"","orcid":"","institution":"Technical University of Munich","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Martin","middleName":"","lastName":"Dierolf","suffix":""},{"id":270074817,"identity":"dd76db49-0957-4c66-9ab0-869d9f90aeea","order_by":4,"name":"Johannes Brantl","email":"","orcid":"","institution":"Technical University of Munich","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Johannes","middleName":"","lastName":"Brantl","suffix":""},{"id":270074818,"identity":"970eca9e-4651-4bba-a1e3-77030f0d8be9","order_by":5,"name":"Guenter Benedikt","email":"","orcid":"","institution":"Technical University of Munich","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Guenter","middleName":"","lastName":"Benedikt","suffix":""},{"id":270074819,"identity":"ee22b889-84e4-4f8d-be08-a285265f83d4","order_by":6,"name":"Christian Petrich","email":"","orcid":"","institution":"Technical University of Munich","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Christian","middleName":"","lastName":"Petrich","suffix":""},{"id":270074820,"identity":"fd4125d6-a77b-45a1-a814-7ee44748b878","order_by":7,"name":"Klaus Achterhold","email":"","orcid":"","institution":"Technical University of Munich","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Klaus","middleName":"","lastName":"Achterhold","suffix":""},{"id":270074821,"identity":"697993b1-ba26-4756-a44d-8749382cc803","order_by":8,"name":"Franz Pfeiffer","email":"","orcid":"","institution":"Technical University of Munich","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Franz","middleName":"","lastName":"Pfeiffer","suffix":""},{"id":270074822,"identity":"6e0078bf-2a73-4f02-855f-eaf044b790a5","order_by":9,"name":"Susanne Grandl","email":"","orcid":"","institution":"Rotkreuzklinikum München","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Susanne","middleName":"","lastName":"Grandl","suffix":""},{"id":270074824,"identity":"3a444482-ce62-43e5-ad13-389ec2c2313a","order_by":10,"name":"Karin Hellerhoff","email":"","orcid":"","institution":"Rotkreuzklinikum München","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Karin","middleName":"","lastName":"Hellerhoff","suffix":""},{"id":270074826,"identity":"61588b8b-50f9-4d02-a93a-51830c9bd826","order_by":11,"name":"Julia Herzen","email":"","orcid":"","institution":"Technical University of Munich","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Julia","middleName":"","lastName":"Herzen","suffix":""}],"badges":[],"createdAt":"2024-01-23 14:41:44","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-3891369/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-3891369/v1","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1038/s41598-024-77346-1","type":"published","date":"2024-10-26T15:58:00+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":67682472,"identity":"57c75882-e5f5-43a8-9d88-5f7b95c0e81f","added_by":"auto","created_at":"2024-10-28 16:14:21","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":2369249,"visible":true,"origin":"","legend":"","description":"","filename":"ScientificReportsgbpcBCT.pdf","url":"https://assets-eu.researchsquare.com/files/rs-3891369/v1_covered_3e3b400b-01d4-44e5-947e-9ea927d14f0b.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Grating-Based Phase-Contrast Breast ComputedTomography at an Inverse Compton Source","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"scientific-reports","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"scirep","sideBox":"Learn more about [Scientific Reports](http://www.nature.com/srep/)","snPcode":"","submissionUrl":"","title":"Scientific Reports","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"Scientific Reports","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"","lastPublishedDoi":"10.21203/rs.3.rs-3891369/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-3891369/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"The introduction of mammography screening programs has significantly reduced breast cancer mortality rates. Nevertheless, some lesions remain undetected, especially in dense breast tissue. Studies have shown that phase-contrast imaging can improve breast cancer diagnosis by increasing soft tissue contrast. Furthermore, grating-based phase-contrast imaging enables the simultaneous acquisition of absorption-, phase-contrast, and scattering, so-called dark-field images. The latter allows the classification of microcalcifications. In addition, breast computed tomography (BCT) systems can identify and discriminate overlapping but clinically relevant structures. This study investigates the benefit of combining grating-based phase-contrast with BCT. For this task, two Photon counting detector (PCD)s are used, and their performance is compared to a flat panel detector in terms of their resolution. The results demonstrate a resolution advantage of PCDs over flat panel detectors. Furthermore, we explore the potential of grating-based phase-contrast breast computed tomography (gbpc-BCT) with a breast phantom and a freshly dissected fibroadenoma. Improved image contrast could be achieved with radiation doses comparable to those used inclinical mammography.","manuscriptTitle":"Grating-Based Phase-Contrast Breast ComputedTomography at an Inverse Compton Source","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-01-31 03:48:24","doi":"10.21203/rs.3.rs-3891369/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Revision requested","date":"2024-06-05T18:01:30+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2024-05-28T08:44:58+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"cf6fdfb3-563c-43bc-a6bb-a1f6f2d07951","date":"2024-04-16T10:47:37+00:00","index":"hide","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2024-02-07T21:51:54+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"232d14b0-a0df-4b98-8b14-a74d7898bebe","date":"2024-02-03T12:08:52+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"1697a76d-d4ef-4f98-985d-1bc99d996fc3","date":"2024-01-28T11:11:29+00:00","index":"hide","fulltext":""},{"type":"reviewersInvited","content":"","date":"2024-01-28T04:39:53+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2024-01-28T04:38:02+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2024-01-27T21:30:53+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2024-01-27T21:27:26+00:00","index":"","fulltext":""},{"type":"submitted","content":"Scientific Reports","date":"2024-01-23T14:39:03+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"scientific-reports","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"scirep","sideBox":"Learn more about [Scientific Reports](http://www.nature.com/srep/)","snPcode":"","submissionUrl":"","title":"Scientific Reports","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"Scientific Reports","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"9c3e7805-36e9-4adb-95ae-0a2681033242","owner":[],"postedDate":"January 31st, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[{"id":28463779,"name":"Biological sciences/Cancer/Breast cancer"},{"id":28463780,"name":"Physical sciences/Optics and photonics/Optical physics/X rays"}],"tags":[],"updatedAt":"2024-10-28T16:09:05+00:00","versionOfRecord":{"articleIdentity":"rs-3891369","link":"https://doi.org/10.1038/s41598-024-77346-1","journal":{"identity":"scientific-reports","isVorOnly":false,"title":"Scientific Reports"},"publishedOn":"2024-10-26 15:58:00","publishedOnDateReadable":"October 26th, 2024"},"versionCreatedAt":"2024-01-31 03:48:24","video":"","vorDoi":"10.1038/s41598-024-77346-1","vorDoiUrl":"https://doi.org/10.1038/s41598-024-77346-1","workflowStages":[]},"version":"v1","identity":"rs-3891369","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-3891369","identity":"rs-3891369","version":["v1"]},"buildId":"CiT4i_kKBbxQbnFL0ufpk","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}