Evaluations of minimally invasive transforaminal lumbar interbody fusion performed with rhBMP-2

Evaluations of minimally invasive transforaminal lumbar interbody fusion performed with rhBMP-2 | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research article Evaluations of minimally invasive transforaminal lumbar interbody fusion performed with rhBMP-2 Bin Lv, Yuting Hou, Xiang Jin, Dan Luo, Lei Wang, Xiang Yao, Jishan Yuan, and 2 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.2.12544/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background: The combination of minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) and recombinant human bone morphogenetic protein 2 (rhBMP-2) is widely used for its advantage of rapid recovery and improved bone fusion. However, no previous study has reported the synergistic effect of MIS-TLIF with rhBMP-2 in patients with degenerative lumbar disease (DLD). Objective: To investigate the radiographic and patient-reported outcomes (PROs) in patients with DLD who underwent MIS-TLIF with and without a low dose of rhBMP-2. Methods: We retrospectively reviewed 48 patients treated with MIS-TLIF from 2013 to 2016. The patients were classified into the rhBMP-2 group (n = 25) and non-rhBMP-2 group (n = 23). Fusion-related parameters were measured before and after the operation. Clinical data included the numeric rating scale (NRS) score, Japanese Orthopedic Association (JOA) scores, and the MOS 36-item short form health survey (SF-36) score, which were documented to evaluate the effect of surgery. Results: In the 48 patients who underwent MIS-TLIF, the operated disc was predominantly at the L4/5 and L5/S1 levels. ADH, MDH, and PDH increased significantly in both groups after surgery (P < 0.05). FH improved in the rhBMP-2 group, but not in the non-rhBMP-2 group. There was no obvious improvement in SA in both groups. Furthermore, the SL showed a significant difference in both groups and a significant improvement over the baseline. The LL showed significant improvement in the two groups at the early follow-up (P < 0.05), but the improvement did not persist. Cage subsidence had no significant effect on different subsidence grades. In addition, no differences in cage subsidence were observed in different types of modic change (MC), except for MC 0 in both groups. There was no difference in PROs even though all clinical outcomes improved significantly during the postoperative follow-up period in both groups. Conclusion: MIS-TLIF with the low doses of rhBMP-2 resulted in an improvement in radiographic and clinical results, but not a longer-lasting restoration for radiographic outcomes. Cage subsidence is not associated with the MC. Further, our clinical data demonstrated no difference between both groups. Orthopedics Minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) Bone morphogenetic protein rhBMP-2 Degenerative lumbar disease Radiographic outcome. Figures Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Background Since its inception, minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) has gained popularity because it offers advantages such as smaller iatrogenic injury, less blood loss, a lower possibility of surgical site infection, and alleviation of adjacent segment degeneration.[1] Additionally, the TLIF procedure shows advantages in the treatment of degenerative diseases because of its ability to preserve the bony structure and pars interarticularis and restore the intervertebral height, foraminal height (FH), and segmental lordosis.[2] However, cage migration within the disc space may cause progressive spinal deformity and narrowing disc space or even intraoperative injuries.[3] BMP is a member of the TGF β superfamily and promotes bone formation by regulating cell differentiation and matrix synthesis.[4] Administration of rhBMP-2, a subtype of BMP, has been combined with the MIS-TLIF procedure due to higher integration rates.[5] However, no previous studies have investigated the radiologic parameters and clinical outcomes of rhBMP-2 administration in the MIS-TLIF procedure. Prior literature demonstrated the presence of adverse effects, such as pseudarthrosis and ectopic bone formation, in many patients.[6] Other studies have further stratified the relationship between clinical outcomes and rhBMP-2 dosage.[7] Although promising results were obtained in rhBMP-2-assisted spinal fusion, the effect was poor since researchers failed to control the confounding variables because of the lack of a specific protocol to evaluate the outcome of surgery.[8] However, recent literature has documented that distinct radiographic changes can be assessed to evaluate the effect of rhBMP-2-assisted spinal fusion. Fusion-related sagittal parameters, cage subsidence, and MC can be well detected on CT or MRI. Jang et al. suggested that there is a relationship between sagittal parameters, cage subsidence, and clinical outcomes in degenerative cervical disease.[9] However, the radiographic sagittal parameters of MIS-TLIF performed with and without rhBMP-2 in the disk space have not been fully evaluated. In the current study, we reviewed our experience with MIS-TLIF to elucidate the effect of rhBMP on the sagittal parameters, cage subsidence, and MC of the operated segment. We aim to explore potential relationships between use of rhBMP-2 and improvement in radiologic parameters and clinical outcomes. Further, possible correlations of these parameters were investigated. Methods This study identified 48 patients who had complaints of low back pain or neurologic symptoms. Data for age, gender, and operated level were collected from inpatient medical records. Single or two-level MIS-TLIF procedures were performed on all patients from March 2013 to February 2016. This protocol was approved by the ethics committee of the Affiliated People's Hospital with Jiangsu University. All patients gave written informed consent for their information to be stored in the hospital database and used for research. This study was conducted according to the principles expressed in the Declaration ofHelsinki. Our exclusion criteria were as follows: spinal fracture, lumbar infection and tumor, prior history of lumbar surgery, and MIS-TLIF operated on levels above the lumbar spine. A total of 25 patients received additional rhBMP-2 treatment (rhBMP-2 group), while 27 patients did not receive rhBMP-2 treatment (non-rhBMP-2 group). We collected clinical data from inpatient medical records, pre- and postoperative plain radiographs, and postoperative CT or MR images. All patients were contacted by cellphone to collect missing information. Demographics and procedure data listed in Table 1 were recorded prospectively for both groups. Radiologic outcome evaluation We measured anterior disc height (ADH), middle disc height (MDH), posterior disc height (PDH), segmental angle (SA), segmental lordosis (SL), and foraminal height (FH) of the operated levels and lumbar lordosis (LL) on pre- and postoperative radiographs to quantify the postoperative distraction of disc height and indirect decompression. We evaluated disk height by measuring the ADH, MDH, and PDH. The ADH was defined as the distance between the anterosuperior edge and the anteroinferior edge, PDH was defined as the distance between the posterior inferior edge and the posterosuperior edge, whereas the MDH was defined as the distance from the inferior endplate to the superior endplate at the midpoints of the vertebral body. The SA was defined as the angle between the superior endplate and the inferior endplate of the operated level. The SL was the angle between the superior endplate and the inferior endplate of the segment. The LL was defined as the angle between the superior endplate of L1 and the superior endplate of S1. (Figure 1) Cage subsidence was evaluated by measuring migration of the cage into the endplate. Cage subsidence was defined as a mean of the sum of the left and right cage subsidence on CT (Figure 2). Clinical outcome evaluation Pain and functional results were documented during the preoperative period and 1, 3, 6, and 12 months postoperatively to evaluate the clinical outcomes. The clinical results included numeric rating scale (NRS) scores, Japanese Orthopedic Association (JOA) scores, and the MOS 36-item short form health survey (SF-36) scores. The NRS scores were adopted to evaluate the intensity of low back pain as well as leg pain. The JOA and SF-36 scores were used to evaluate the daily functionality of patients. Statistical analyses We performed data analysis with SPSS (version 21.0, SPSS Inc, Chicago, IL). We compared the pre- and postoperative radiologic and clinical outcomes with independent and paired Student t-tests. The mean values of the two groups were compared by one-way ANOVA. We calculated the correlation between the variables using Pearson correlation coefficients and Spearman correlation coefficients. 𝑃 values less than 0.05 were considered statistically significant. Results The patients presented with spondylolisthesis, spinal stenosis, and recurrent disc herniation. Both groups showed no significant difference with respect to mean age and gender distribution. (Table 1) Radiologic evaluation The postoperative ADH, MDH, and PDH at early follow-up differed significantly from the preoperative and final follow-up values in both groups (P < 0.05) (Figure 3). The postoperative FH at early follow-up differed significantly from the preoperative and final follow-up values in the rhBMP-2 group (P < 0.05). Furthermore, the postoperative FH at the final follow-up differed significantly from the preoperative and early follow-up values in the non-rhBMP-2 group (P < 0.05). The segment angle at the final follow-up differed significantly from the early follow-up value in the rhBMP-2 group (P < 0.05). The SL in the rhBMP-2 group at the final follow-up period differed significantly from the baseline value and the SL evaluated at the final follow-up in the non-rhBMP-2 group (P < 0.05). The LL at early follow-up in the rhBMP-2 group differed significantly from the LL evaluated at early follow-up in the non-rhBMP-2 group (P < 0.05) (Table 2) (Figure 4). Our results revealed a stronger correlation between ADH and MDH (r = 0.660; P = 0.001). The MDH was correlated with the PDH (r = 0.656; P = 0.001). The PDH was correlated with the FH (r = 0.449; P = 0.024). The FH was correlated with the NRS leg (r = 0.476; P = 0.016). The SA was correlated with the SL (r = 0.427; P = 0.033). The SL was also correlated with the LL (r = 0.478; P = 0.016), NRS back (r = 0.427; P = 0.033), and NRS leg (r = 0.409; P = 0.043). The LL was correlated with the NRS back (r = 0.400; P = 0.048). Cage subsidence or MC were not related to postoperative sagittal parameters (Data not shown). (Table 3) Subsidence and modic change Modic change was classified as type 0 in 10 rhBMP-2 cases and 11 non-rhBMP-2 cases, type I in one rhBMP-2 case and two non-rhBMP-2 cases, type II in 15 rhBMP-2 cases and 12 non-rhBMP-2 cases, and type III in one rhBMP-2 case and no non-rhBMP-2 cases. Grade 1 subsidence was 0.61 ± 0.23 mm in the rhBMP-2 group and 0.71 ± 0.12 mm in the non-rhBMP-2 group, grade 2 subsidence was 1.47 ± 0.31 mm in the rhBMP-2 group and 1.76 ± 0.46 mm in the non-rhBMP-2 group, and grade 3 subsidence was 3.01 ± 0.00 mm in the non-rhBMP-2 group (Table 4). Cage subsidence was positively related to the type of MC, with the most severe MC showing maximum cage subsidence. However, cage subsidence showed no difference in different types of MC, except for the normal endplate. (Figure 5) Clinical evaluation The NRS scores for back pain significantly improved 6 months postoperatively (from 6.32 ± 0.73 to 2.12 ± 0.81 in the rhBMP-2 group and from 6.26 ± 0.79 to 2.01 ± 0.29 in the non-rhBMP-2 group, 𝑃 < 0.05). NRS scores for leg pain also significantly increased 6 months postoperatively (from 6.32 ± 0.73 to 2.04 ± 0.52 in the rhBMP-2 group and from 6.01 ± 0.59 to 1.78 ± 0.65 in the non-rhBMP-2 group, 𝑃 < 0.05). The JOA score significantly improved at 1 month in both groups (from 15.28 ± 5.71 to 23.09 ± 2.99 for the rhBMP-2 group and from 14.57 ± 2.83 to 23.65 ± 0.71 for the non-rhBMP-2 group, 𝑃 < 0.05). SF-36 scores significantly improved at the final follow-up (from 45.49 ± 3.13 to 70.22 ± 5.08 in the rhBMP-2 group and from 45.99 ± 5.56 to 70.33 ± 5.68 in the non-rhBMP-2 group, 𝑃 < 0.05). (Figure 6) Complications No cases of intraoperative complications, such as neurological damage, postoperative alterations in sexual activity, or ejaculation-related pain were found. Different degrees of cage subsidence were found in all cases during the follow-up period. Overall, our results demonstrated a low complication rate for MIS-TLIF using rhBMP-2. Discussion Dose of rhBMP-2 rhBMP-2 has been proven to be effective in relieving donor site pain and reduce morbidity.[10] However, rhBMP-2 also shows a series of inflammatory dose-related complications, including radiculitis, osteolysis, and ectopic bone formation.[11] Owens K et al. demonstrated a modest complication rate in MIS-TLIF procedure, with rhBMP-2-associated complications occurring infrequently.[12] Even though the optimal rhBMP-2 dose in TLIF procedures remains a matter of debate, Villavicencio AT et al. reported that there was no correlation between the dose of rhBMP-2 and the incidence of rhBMP-2-induced radiculitis.[13] Alan T et al. confirmed the effectiveness and safety of a combination of MIS-TLIF and rhBMP-2 in lumbar fusion whereas no significant difference was found in clinical outcome between MIS-TLIF and open procedures.[13] A few years later, they adopted a wide dose range (2–12 mg) of rhBMP-2. Their retrospective study did not determine the relationship between the rhBMP-2 doses and the radicular symptoms. [14] To date, the 4-6 mg/level dose of rhBMP-2 is widely adopted in clinical practice. [15] Here, our adoption of low rhBMP-2 dosage (2 mg/ level) was effective and safe in the MIS-TLIF procedures and yielded satisfactory radiological and clinical outcomes. Fusion rate Many studies assessing long-term follow-up data have shown that poor bone fusion results in degeneration of the vertebral body, functional disability, lumbar spine instability, and pain. [16, 17] We observed a higher fusion rate in the rhBMP-2 group than in the non-rhBMP-2 group, which was consistent with prior studies reporting a higher fusion rate compared with autologous bone grafts. [18] Vaidya et al. demonstrated that radiologic signs of fusion in patients receiving allografts and rhBMP-2 appeared earlier than those in patients not receiving rhBMP-2, with the signs appearing at 6 and 19 months, respectively. However, the exact time of fusion is difficult to determine because it is unrealistic for return visit patients to undergo surgical reexploration in the short time interval after surgery. We confirmed that application of low doses of rhBMP-2 leads to a significantly different fusion rate between both groups at 3 months postoperatively. Radiographic evidence of reexploration for recurrence of pain suggests that the cage was securely fused by 8-12 weeks, which indicates that the actual process began sooner than that detected on radiography. [19] Sagittal parameters Previous studies demonstrated that disc degeneration causes an increase in ADH and PDH. [20, 21] Hsieh et al. found that SL decreased at the operated segment. [22] The compensatory increase in PDH relative to the increase in ADH led to the maintenance of the SL. Biomechanical research has suggested that procedures improve the disc height and FH deficits caused by disc degeneration. [23] We found a significant increase in ADH, MDH, and PDH at the operated level in both groups. The disc height and FH in the rhBMP-2 group decreased more significantly than that in the non-rhBMP-2 group. Further, recent studies involving MIS-TLIF evaluated SL and presented variable results. Some reported an insufficient ability of MIS-TLIF to restore SL at the surgical level, whereas others showed substantial increases in SL. We found a significant increase in LL in patients with DLD, which was consistent with a previous study that confirmed that the interbody fusion is highly effective in improving LL.[24] Some investigators demonstrated an association between postoperative LL and better clinical outcomes. Previous studies evaluated short- and long-term complications associated with off-label rhBMP-2 use with TLIF. Some studies suggest that these complications may be dose-positive, and the higher the dose, the greater the probability of complications. [25] Complications and results were analyzed by BMP dose and primary versus revision surgery. Based on these results, surgical technique and rhBMP-2 dose recommendations were proposed. Disc height restoration No consensus regarding the results of the restoration of disc height was reached. Liu et al. suggested that the improvement in disc space height plays a vital role in facet joint subluxation. [26] Kaito et al. proposed that the distraction of disc space was a potent risk factor for the progression of adjacent segment disease (ASD), which may affect clinical outcomes of patients. [27] Michael C et al. found that disc height restoration was positively associated with segmental lordosis. [28] Our results are the first to investigate the effect of rhBMP-2 in the restoration of disc height. However, even though rhBMP-2 slightly slowed down restoration of disc height and FH to some extent, we did not find any significant differences in the two groups. Biomechanical studies have proven that diminished LL may increase the risk of ASD. [29] Kepler et al. reported that the decrease in LL was related to worse clinical outcomes, which was consistent with our results. [30] Hence, our results showed that rhBMP-2 increased postoperative SL and LL by 0.9° and 3.1°, thus improving clinical outcomes by restoring sagittal alignment. Some researchers found a relationship between restoration of LL and improvement in clinical outcomes. [31] However, the relationship between radiographic improvement and clinical outcomes was not found in the current study. Postoperative maintenance of the SL may lead to a compensatory gain of adjacent segment lordosis, which is confirmed by the correlation between the postoperative LL and the SL of the adjacent levels. Subsidence and MC Several factors, including age, sex, and bone mineral density were reported to affect cage subsidence in MIS-TLIF. Tokuhashi et al. demonstrated that the average cage subsidence was 2.7 ± 3.4 mm on the caudal surface and 4.0 ± 2.3 mm on the cranial surface. [32] Their results were higher than those reported in the current study. The differences in cage subsidence may be attributable to the different measurement methods. CT could precisely measure the amount of subsidence during the bone remodeling process, so the average subsidence and prevalence of subsidence measured by plain radiographs were lower than those reported in other studies that used CT. David et al. reported that intact endplates increased strength and resistance to subsidence. [33] MC was associated with vertebral body structural changes such as disc herniation and vertebral endplate defect. [34] We found that cage subsidence in a different type of MC showed no significant difference except for normal endplate. Our result indicates that MC in the vertebral body may affect endplate preparation, which plays a vital role in preventing cage subsidence. However, our data did not show an improvement in cage subsidence in the rhBMP-2 group. Clinical outcome Even though all clinical outcomes improved significantly in the two groups, we found no significant difference between the groups. We demonstrated that the degrees of sagittal correction, fusion rates, and incidence of cage migration were not related with clinical outcomes in the first 12 months postoperatively. Compared with prior studies, our procedure integrated the advantages of MIS-TLIF and rhBMP-2 and confirmed that MIS-TLIF combined with rhBMP-2 is a better choice for lumbar degenerative disease. Limitations Some limitations could not be avoided in this retrospective study. First, as the properties of L4-5 and L5-S1 are different in terms of their contribution to disc height, FH, SA, and the dimensions of the disc space, the bias resulting from the different numbers of operated levels could not be avoided. Second, our sample size was too small to obtain an accurate evaluation of the results. Third, long-term postoperative clinical assessment data were unavailable because some patients were lost to follow-up, making it impossible to reliably assess the clinical outcome of surgery. Fourth, our results did not identify the optimal rhBMP-2 dose in DLD surgeries. Prospective, randomized clinical trials are needed to determine the optimal rhBMP-2 dosage and complications. Conclusions We conclude from this research that single-level MIS-TLIF combined with or without rhBMP-2 significantly increased the ADH, MDH, and PDH but not the SL. However, LL shows a slight but significant improvement resulting from an increase in the cranial SL. A higher fusion rate was observed in the rhBMP-2 group. However, intraoperative use of rhBMP-2 in the MIS-TLIF procedure has no effect on postoperative clinical outcomes since the NRS scores, JOA scores, and SF-36 scores in both groups were not statistically different. Abbreviations ADH: anterior disc height; MDH: middle disc height; PDH: posterior disc height ; FH: foraminal height; SA:segmental angle; SL: segmental lordosis; LL: lumbar lordosis; NRS: numeric rating scale score; JOA: Japanese Orthopedic Association scores; SF-36: the MOS 36-item short form health survey score; MIS-TLIF: minimally invasive transforaminal lumbar interbody fusion; rhBMP-2: recombinant human bone morphogenetic protein 2; DLD: degenerative lumbar disease; ASD: adjacent segment disease; MC: modic change Declarations Ethics approval and consent to participate The study was approved by the Ethics Committee of the Affiliated People's Hospital of Jiangsu University; due to the retrospective nature of the study, the need for informed consent was waived. Consent for Publication Not applicable. Availability of data and material All data has been showed in tables and picutres. Competing interests: The authors declare that they have no conflict of interest. Funding: This study was sponsored by the Clinical Medicine Science and Technology Development Foundation of Jiangsu University (Grant No: JLY20180047) and the Clinical Medicine Science and Technology Development Foundation of Jiangsu University (Grant No: JLY20180271). Authors' contributions BL, YTH, DL and LW conceived and designed the study; XY, JSY, and AQH performed the experiments; XY and AQH analysed the data; BL, YTH and RGC wrote the paper; AQH, JSY, and LW reviewed and edited the manuscript. BL performed major revision and minor revision. All authors read and approved the manuscript. Acknowledgment We would like to thank Dr. Xiaozheng Yang in the Shangrao People's Hospital for data collection and analytical support. References Khan NR, Clark AJ, Lee SL, Venable GT, Rossi NB, Foley KT. Surgical Outcomes for Minimally Invasive vs Open Transforaminal Lumbar Interbody Fusion: An Updated Systematic Review and Meta-analysis. Neurosurgery. 2015;77(6):847-74; discussion 74. 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Epub 2009/05/01. doi: 10.1227/01.neu.0000343544.77456.46. PubMed PMID: 19404155. Carlisle P, Guda T, Silliman DT, Burdette AJ, Talley AD, Alvarez R, et al. Localized low-dose rhBMP-2 is effective at promoting bone regeneration in mandibular segmental defects. J Biomed Mater Res B Appl Biomater. 2018. Epub 2018/09/29. doi: 10.1002/jbm.b.34241. PubMed PMID: 30265782. Tian H, Wu A, Guo M, Zhang K, Chen C, Li X, et al. Adequate Restoration of Disc Height and Segmental Lordosis by Lumbar Interbody Fusion Decreases Adjacent Segment Degeneration. World Neurosurg. 2018;118:e856-e64. Epub 2018/07/22. doi: 10.1016/j.wneu.2018.07.075. PubMed PMID: 30031179. Kaito T, Hosono N, Fuji T, Makino T, Yonenobu K. Disc space distraction is a potent risk factor for adjacent disc disease after PLIF. Archives of orthopaedic and trauma surgery. 2011;131(11):1499-507. Epub 2011/06/28. doi: 10.1007/s00402-011-1343-0. PubMed PMID: 21706306. Liebensteiner MC, Jesacher G, Thaler M, Gstoettner M, Liebensteiner MV, Bach CM. Restoration and preservation of disc height and segmental lordosis with circumferential lumbar fusion: a retrospective analysis of cage versus bone graft. Journal of spinal disorders & techniques. 2011;24(1):44-9. Epub 2011/01/29. doi: 10.1097/BSD.0b013e3181d67c7c. PubMed PMID: 21270626. Rothenfluh DA, Mueller DA, Rothenfluh E, Min K. Pelvic incidence-lumbar lordosis mismatch predisposes to adjacent segment disease after lumbar spinal fusion. Eur Spine J. 2015;24(6):1251-8. Epub 2014/07/16. doi: 10.1007/s00586-014-3454-0. PubMed PMID: 25018033. Kepler CK, Rihn JA, Radcliff KE, Patel AA, Anderson DG, Vaccaro AR, et al. Restoration of lordosis and disk height after single-level transforaminal lumbar interbody fusion. Orthop Surg. 2012;4(1):15-20. Epub 2012/02/01. doi: 10.1111/j.1757-7861.2011.00165.x. PubMed PMID: 22290814. Than KD, Park P, Fu KM, Nguyen S, Wang MY, Chou D, et al. Clinical and radiographic parameters associated with best versus worst clinical outcomes in minimally invasive spinal deformity surgery. J Neurosurg Spine. 2016;25(1):21-5. Epub 2016/03/05. doi: 10.3171/2015.12.spine15999. PubMed PMID: 26943254. Tokuhashi Y, Ajiro Y, Umezawa N. Subsidence of metal interbody cage after posterior lumbar interbody fusion with pedicle screw fixation. Orthopedics. 2009;32(4). Epub 2009/04/25. PubMed PMID: 19388615. Briski DC, Goel VK, Waddell BS, Serhan H, Kodigudla MK, Palepu V, et al. Does Spanning a Lateral Lumbar Interbody Cage Across the Vertebral Ring Apophysis Increase Loads Required for Failure and Mitigate Endplate Violation. Spine. 2017;42(20):E1158-e64. Epub 2017/05/05. doi: 10.1097/brs.0000000000002158. PubMed PMID: 28472018. Lam KS. MRI follow-up of subchondral signal abnormalities in a selected group of chronic low back pain patients. Eur Spine J. 2008;17(10):1309-10. Epub 2008/09/17. doi: 10.1007/s00586-008-0781-z. PubMed PMID: 18795340; PubMed Central PMCID: PMCPMC2556469. Tables Table 1. Patient baseline characteristics Demographic Data MIS-TLIF P Value rhBMP=25 Non-rhBMP=27 Age, years 58.2±9.2 57.8±8.7 0.779 Female, n (%) 17/25 15/23 0.357 Diagnosis 0.490 Spondylolisthesis 6 11 Spinal stenosis 9 9 Recurrent disc herniation 7 10 Level 0.443 L3–4 2 2 L4–5 21 19 L5–S1 3 7 Table 2. Clinical outcomes before and after surgery Group Pre-op Early follow up Final follow up ADH 23 non-rhBMP-2 12.13±2.74 15.91±2.48a 12.27±3.58b 25 rhBMP-2 12.6±2.6 15.17±2.73a 12.18±2.61b MDH 23 non-rhBMP-2 10.72±2.00 12.80±2.10a 10.72±2.05b 25 rhBMP-2 10.59±2.08 12.68±1.84a 10.70±1.69b PDH 23 non-rhBMP-2 8.23±1.44 8.73±1.58 7.74±1.48b 25 rhBMP-2 7.62±1.51 9.36±1.54a 7.78±1.34b FH 23 non-rhBMP-2 18.50±2.72 19.18±2.69 17.5±2.72ab 25 rhBMP-2 18.14±2.86 20.55±2.10a 18.40±2.26b SA 23 non-rhBMP-2 8.60±4.71 8.38±3.11 9.33±3.46 25 rhBMP-2 9.09±3.52 8.33±3.07 10.12±3.76b SL 23 non-rhBMP-2 17.03±6.30 18.99±4.29 19.51±4.90* 25 rhBMP-2 17.01±6.89 15.72±7.22 15.26±7.36a LL 23 non-rhBMP-2 39.58±14.61 40.86±10.08* 44.68±11.58 25 rhBMP-2 38.56±15.13 34.80±10.51 40.7±12.88b Note: a P < 0.05 vs. presurgery; b P < 0.05 vs early follow-up. *indicates P < 0.05 between the non -rhBMP-2 and rhBMP-2 groups Table 3. Correlation between postoperative radiologic parameters and clinical outcomes ADH MDH PDH FH SA SL LL NRS Back NRS Leg JOA SF36 ADH 1 R = 0.660 R = 0.556 R = 0.401 R = 0.168 R = 0.248 R = 0.075 R = -0.177 R = 0.402 R = 0.011 R = 0.120 𝑃 =0.001† 𝑃 =0.004* 𝑃 =0.047* 𝑃 =0.423 𝑃 =0.231 𝑃 =0.720 𝑃 =0.396 𝑃 =0.046* 𝑃 =0.959 𝑃 =0.567 MDH 1 R = 0.656 R = 0.267 R = -0.157 R = 0.304 R = -0.040 R = -0.364 R = 0.169 R = -0.167 R = 0.376 𝑃 =0.001† 𝑃 =0.196 𝑃 =0.454 𝑃 =0.139 𝑃 =0.850 𝑃 =0.074 𝑃 =0.418 𝑃 =0.426 𝑃 =0.064 PDH 1 R = 0.449 R = -0.116 R = 0.138 R = -0.061 R = -0.146 R = 0.258 R = -0.089 R = 0.222 𝑃 =0.024* 𝑃 =0.580 𝑃 =0.511 𝑃 =0.773 𝑃 =0.486 𝑃 =0.214 𝑃 =0.673 𝑃 =0.287 FH 1 R = -0.153 R = 0.024 R = -0.172 R = 0.188 R = 0.476 R = 0.200 R = 0.109 𝑃 =0.465 𝑃 =0.909 𝑃 =0.410 𝑃 =0.367 𝑃 =0.016* 𝑃 =0.337 𝑃 =0.604 SA 1 R = 0.427 * R = 0.640 -0.102 R = -0.150 R = 0.327 R = 0.008 𝑃 =0.033* 𝑃 =0.001 𝑃 =0.627 𝑃 =0.474 𝑃 =0.110 𝑃 =0.970 SL 1 R = .478 * R = -0.427 R = -0.409 R = -0.217 R = -0.041 𝑃 =0.016* 𝑃 =0.033* 𝑃 =0.043* 𝑃 =0.298 𝑃 =0.846 LL 1 R = -0.400 R = -0.094 R = 0.112 R = 0.135 𝑃 =0.048* 𝑃 =0.654 𝑃 =0.595 𝑃 =0.520 NRS Back 1 0.288 𝑃 =0.162 R = 0.229 𝑃 =0.271 R = 0.045 𝑃 =0.831 NRS Leg 1 R = -0.047 𝑃 =0.823 R = 0.068 𝑃 =0.746 JOA 1 R = 0.262 𝑃 =0.206 SF-36 1 *Statistically significant values at the 0.05 level, by Pearson correlation coefficient. †Statistically significant values at the 0.001 level, by Pearson correlation coefficient. Table 4 Modic change and cage subsidence data in different groups rhBMP-2 non-rhBMP-2 P value Modic 0 10 11 0.046 Modic 1 1 2 / Modic 2 15 12 0.591 Modic 3 1 0 / Grade 1 0.61 ± 0.23 0.71 ± 0.12 0.295 Grade 2 1.47 ± 0.31 1.76 ± 0.46 0.095 Grade 3 / 3.01 ± 0.00 / * Statistically significant among groups. † Values are presented as means ± SD. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-3300","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research article","associatedPublications":[],"authors":[{"id":124739,"identity":"5ec0bd3a-77c1-4292-9896-5382308c2ba4","order_by":1,"name":"Bin Lv","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAuUlEQVRIiWNgGAWjYDCCAwyMBxgbJBj4GRgbiNbCANYi2UCiFgYGgwPEuovv9gGGw7w7LPKMzx9ue/CDwU5Ol5BlkucSgFrOSBSb3UhsN+xhSDY2I2SdwRkGhoMz2yQSt91gbJPgYTiQuI1oLZv7D7ZJ/iFWy4GPQC0bGBLbpImyRRKs5YxE4owbQC0yBkT4he8MA+ODxB11if39x59JvqmwkyOohYGB/wOyOwkqHwWjYBSMglFADAAAqJxF0KU0lqsAAAAASUVORK5CYII=","orcid":"https://orcid.org/0000-0002-4368-0232","institution":"The affiliated people's with Jiangsu University","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Bin","middleName":"","lastName":"Lv","suffix":""},{"id":124740,"identity":"495d634b-13d9-4819-8584-3a26a54c035a","order_by":2,"name":"Yuting Hou","email":"","orcid":"","institution":"Jiangning hospital affiliated with nanjing medical university","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Yuting","middleName":"","lastName":"Hou","suffix":""},{"id":124741,"identity":"77cb3436-4338-4436-8225-3d87b11e317b","order_by":3,"name":"Xiang Jin","email":"","orcid":"","institution":"Suzhou Municipal Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Xiang","middleName":"","lastName":"Jin","suffix":""},{"id":124742,"identity":"a138747c-6eb3-4218-8581-065c98063d90","order_by":4,"name":"Dan Luo","email":"","orcid":"","institution":"peking university school of nursing","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Dan","middleName":"","lastName":"Luo","suffix":""},{"id":124743,"identity":"caa33468-4b9f-4054-90c6-09430f7d8e3f","order_by":5,"name":"Lei Wang","email":"","orcid":"","institution":"The affiliated People's Hospital with Jiangsu University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Lei","middleName":"","lastName":"Wang","suffix":""},{"id":124744,"identity":"bcb82f95-54ca-4018-80c5-d61ac16f6a59","order_by":6,"name":"Xiang Yao","email":"","orcid":"","institution":"The Affiliated people’s Hospital with Jiangsu University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Xiang","middleName":"","lastName":"Yao","suffix":""},{"id":124745,"identity":"d6fba310-0d09-4b13-9793-5c2a4ff4f111","order_by":7,"name":"Jishan Yuan","email":"","orcid":"","institution":"The affiliated people’s with Jiangsu University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Jishan","middleName":"","lastName":"Yuan","suffix":""},{"id":124746,"identity":"86820bdf-1718-4f53-8b89-c4d75556c7dd","order_by":8,"name":"Anquan Huang","email":"","orcid":"","institution":"Suzhou Municipal Hospital","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Anquan","middleName":"","lastName":"Huang","suffix":""},{"id":124747,"identity":"9acf15c9-eead-4c67-861d-23059db1fd51","order_by":9,"name":"Rongguo Chen","email":"","orcid":"","institution":"nanjing hospital of traditional chinese medicine","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Rongguo","middleName":"","lastName":"Chen","suffix":""}],"badges":[],"createdAt":"2019-08-02 14:00:30","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.2.12544/v1","doiUrl":"https://doi.org/10.21203/rs.2.12544/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":270472,"identity":"2fe7face-0c22-424f-b242-e4d6457b5f41","added_by":"auto","created_at":"2019-12-17 14:27:50","extension":"jpg","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":137013,"visible":true,"origin":"","legend":"Measurement of sagittal parameters on pre- and postoperative radiographs. \nAbbreviation: ADH, anterior disc height; MDH, middle disc height; PDH, posterior disc height; FH, foraminal height; SL, segmental lordosis; SA, segmental angle; LL, lumbar lordosis.","description":"","filename":"Figure1.jpg","url":"https://assets-eu.researchsquare.com/files/1613cbae-78c3-4d12-90b0-4ee1fc32441e/v1/Figure 1.jpg"},{"id":270473,"identity":"c5182589-7eac-49c7-a06f-b03db182313e","added_by":"auto","created_at":"2019-12-17 14:27:50","extension":"jpg","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":93886,"visible":true,"origin":"","legend":"Cage subsidence was evaluated by measuring the maximal cranial or caudal migration of the cage into the endplate.","description":"","filename":"Figure2.jpg","url":"https://assets-eu.researchsquare.com/files/1613cbae-78c3-4d12-90b0-4ee1fc32441e/v1/Figure 2.jpg"},{"id":270474,"identity":"1fb7c4ae-94bb-44ad-a6c2-06121824a9e8","added_by":"auto","created_at":"2019-12-17 14:27:51","extension":"jpg","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":382009,"visible":true,"origin":"","legend":"Pre- and postoperative disc height in both groups. \nAbbreviations: ADH, anterior disc height; MDH, middle disc height; PDH, posterior disc height. Differences are statistically significant if P \u003c 0.05.","description":"","filename":"Figure3.jpg","url":"https://assets-eu.researchsquare.com/files/1613cbae-78c3-4d12-90b0-4ee1fc32441e/v1/Figure 3.jpg"},{"id":270475,"identity":"1558018d-0139-4e04-8ea9-f39a4063ce58","added_by":"auto","created_at":"2019-12-17 14:27:51","extension":"jpg","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":483668,"visible":true,"origin":"","legend":"MIS-TLIF combined with or without rhBMP-2 restored foraminal height, segment angle, and segment lordosis in patients with DLD. A: The rhBMP-2 group (n = 27) showed a greater improvement in foraminal height during the early follow-up, but the non-rhBMP-2 group (n = 25) showed a slight improvement during the early follow-up and restoration in foraminal height in the final follow-up. B: The rhBMP-2 group did not show an improvement in the segment angle. C: The rhBMP-2 group showed a significant improvement in segment lordosis over baseline and the non-rhBMP-2 group in the final follow-up. D: The rhBMP-2 group showed a significant improvement in lumbar lordosis compared to that in the final follow-up and the non-rhBMP-2 group in the early follow-up. Differences are statistically significant if P \u003c 0.05.","description":"","filename":"Figure4.jpg","url":"https://assets-eu.researchsquare.com/files/1613cbae-78c3-4d12-90b0-4ee1fc32441e/v1/Figure 4.jpg"},{"id":270476,"identity":"a958a560-8b4c-4868-8674-2b5a42f735ff","added_by":"auto","created_at":"2019-12-17 14:27:51","extension":"jpg","order_by":5,"title":"Figure 5","display":"","copyAsset":false,"role":"figure","size":187641,"visible":true,"origin":"","legend":"rhBMP-2 had no significant effects on cage subsidence in different cage subsidence groups and modic change groups. rhBMP-2 had no significant effect on cage subsidence grade (A), modic change (B) compared to the non-rhBMP-2 group. Data represent mean ± SE. Differences are statistically significant if P \u003c 0.05.","description":"","filename":"Figure5.jpg","url":"https://assets-eu.researchsquare.com/files/1613cbae-78c3-4d12-90b0-4ee1fc32441e/v1/Figure 5.jpg"},{"id":270477,"identity":"63039507-8e63-4687-aed3-93965682c937","added_by":"auto","created_at":"2019-12-17 14:27:51","extension":"jpg","order_by":6,"title":"Figure 6","display":"","copyAsset":false,"role":"figure","size":377057,"visible":true,"origin":"","legend":"The clinical outcomes of DLD in both groups. rhBMP-2 had no significant effects on the NRS back scores (A), NRS leg scores (B), mJOA scores (C), and SF-36 scores (D) comparing to the scores in the non-rhBMP-2 group. Abbreviation: NRS, numeric rating scale; SF-36, the MOS item short from health survey; JOA, Japanese Orthopedic Association Scores. \n* indicate statistically significant compared with baseline.","description":"","filename":"Figure6.jpg","url":"https://assets-eu.researchsquare.com/files/1613cbae-78c3-4d12-90b0-4ee1fc32441e/v1/Figure 6.jpg"},{"id":13469578,"identity":"c1dfb246-a62d-4aea-8322-924ca456c9bf","added_by":"auto","created_at":"2021-09-16 21:02:15","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":830731,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-3300/v1/5fc58bcf-f914-4883-b84d-393892eeafe5.pdf"}],"financialInterests":"","formattedTitle":"Evaluations of minimally invasive transforaminal lumbar interbody fusion performed with rhBMP-2","fulltext":[{"header":"Background","content":"\u003cp\u003eSince its inception, minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) has gained popularity because it offers advantages such as smaller iatrogenic injury, less blood loss, a lower possibility of surgical site infection, and alleviation of adjacent segment degeneration.[1] Additionally, the TLIF procedure shows advantages in the treatment of degenerative diseases because of its ability to preserve the bony structure and pars interarticularis and restore the intervertebral height, foraminal height (FH), and segmental lordosis.[2] However, cage migration within the disc space may cause progressive spinal deformity and narrowing disc space or even intraoperative injuries.[3]\u003c/p\u003e\n\u003cp\u003eBMP is a member of the TGF\u003csub\u003e\u0026beta; \u003c/sub\u003esuperfamily and promotes bone formation by regulating cell differentiation and matrix synthesis.[4] Administration of rhBMP-2, a subtype of BMP, has been combined with the MIS-TLIF procedure due to higher integration rates.[5] However, no previous studies have investigated the radiologic parameters and clinical outcomes of rhBMP-2 administration in the MIS-TLIF procedure. Prior literature demonstrated the presence of adverse effects, such as pseudarthrosis and ectopic bone formation, in many patients.[6] Other studies have further stratified the relationship between clinical outcomes and rhBMP-2 dosage.[7] Although promising results were obtained in rhBMP-2-assisted spinal fusion, the effect was poor since researchers failed to control the confounding variables because of the lack of a specific protocol to evaluate the outcome of surgery.[8] However, recent literature has documented that distinct radiographic changes can be assessed to evaluate the effect of rhBMP-2-assisted spinal fusion. Fusion-related sagittal parameters, cage subsidence, and MC can be well detected on CT or MRI. Jang et al. suggested that there is a relationship between sagittal parameters, cage subsidence, and clinical outcomes in degenerative cervical disease.[9] However, the radiographic sagittal parameters of MIS-TLIF performed with and without rhBMP-2 in the disk space have not been fully evaluated.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eIn the current study, we reviewed our experience with MIS-TLIF to elucidate the effect of rhBMP on the sagittal parameters, cage subsidence, and MC of the operated segment. We aim to explore potential relationships between use of rhBMP-2 and improvement in radiologic parameters and clinical outcomes. Further, possible correlations of these parameters were investigated.\u003c/p\u003e"},{"header":"Methods","content":"\u003cp\u003eThis study identified 48 patients who had complaints of low back pain or neurologic symptoms. Data for age, gender, and operated level were collected from inpatient medical records. Single or two-level MIS-TLIF procedures were performed on all patients from March 2013 to February 2016. This protocol was approved by the ethics committee of the Affiliated People's Hospital with Jiangsu University. All patients gave written informed consent for their information to be stored in the hospital database and used for research. This study was conducted according to the principles expressed in the Declaration ofHelsinki. Our exclusion criteria were as follows: spinal fracture, lumbar infection and tumor, prior history of lumbar surgery, and MIS-TLIF operated on levels above the lumbar spine. A total of 25 patients received additional rhBMP-2 treatment (rhBMP-2 group), while 27 patients did not receive rhBMP-2 treatment (non-rhBMP-2 group). We collected clinical data from inpatient medical records, pre- and postoperative plain radiographs, and postoperative CT or MR images. All patients were contacted by cellphone to collect missing information. Demographics and procedure data listed in Table 1 were recorded prospectively for both groups.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eRadiologic \u003c/strong\u003e\u003cstrong\u003eoutcome\u003c/strong\u003e\u003cstrong\u003e evaluation\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWe measured anterior disc height (ADH), middle disc height (MDH), posterior disc height (PDH), segmental angle (SA), segmental lordosis (SL), and foraminal height (FH) of the operated levels and lumbar lordosis (LL) on pre- and postoperative radiographs to quantify the postoperative distraction of disc height and indirect decompression. We evaluated disk height by measuring the ADH, MDH, and PDH. The ADH was defined as the distance between the anterosuperior edge and the anteroinferior edge, PDH was defined as the distance between the posterior inferior edge and the posterosuperior edge, whereas the MDH was defined as the distance from the inferior endplate to the superior endplate at the midpoints of the vertebral body. The SA was defined as the angle between the superior endplate and the inferior endplate of the operated level. The SL was the angle between the superior endplate and the inferior endplate of the segment. The LL was defined as the angle between the superior endplate of L1 and the superior endplate of S1. (Figure 1) Cage subsidence was evaluated by measuring migration of the cage into the endplate. Cage subsidence was defined as a mean of the sum of the left and right cage subsidence on CT (Figure 2).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eClinical outcome evaluation\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003ePain and functional results were documented during the preoperative period and 1, 3, 6, and 12 months postoperatively to evaluate the clinical outcomes. The clinical results included numeric rating scale (NRS) scores, Japanese Orthopedic Association (JOA) scores, and the MOS 36-item short form health survey (SF-36) scores. The NRS scores were adopted to evaluate the intensity of low back pain as well as leg pain. The JOA and SF-36 scores were used to evaluate the daily functionality of patients.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eStatistical analyses\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWe performed data analysis with SPSS (version 21.0, SPSS Inc, Chicago, IL). We compared the pre- and postoperative radiologic and clinical outcomes with independent and paired Student t-tests. The mean values of the two groups were compared by one-way ANOVA. We calculated the correlation between the variables using Pearson correlation coefficients and Spearman correlation coefficients. 𝑃 values less than 0.05 were considered statistically significant.\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003eThe patients presented with spondylolisthesis, spinal stenosis, and recurrent disc herniation. Both groups showed no significant difference with respect to mean age and gender distribution. (Table 1)\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eRadiologic evaluation\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe postoperative ADH, MDH, and PDH at early follow-up differed significantly from the preoperative and final follow-up values in both groups (P \u0026lt; 0.05) (Figure 3). The postoperative FH at early follow-up differed significantly from the preoperative and final follow-up values in the rhBMP-2 group (P \u0026lt; 0.05). Furthermore, the postoperative FH at the final follow-up differed significantly from the preoperative and early follow-up values in the non-rhBMP-2 group (P \u0026lt; 0.05). The segment angle at the final follow-up differed significantly from the early follow-up value in the rhBMP-2 group (P \u0026lt; 0.05). The SL in the rhBMP-2 group at the final follow-up period differed significantly from the baseline value and the SL evaluated at the final follow-up in the non-rhBMP-2 group (P \u0026lt; 0.05). The LL at early follow-up in the rhBMP-2 group differed significantly from the LL evaluated at early follow-up in the non-rhBMP-2 group (P \u0026lt; 0.05) (Table 2) (Figure 4).\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eOur results revealed a stronger correlation between ADH and MDH (r = 0.660; P = 0.001). The MDH was correlated with the PDH (r = 0.656; P = 0.001). The PDH was correlated with the FH (r = 0.449; P = 0.024). The FH was correlated with the NRS leg (r = 0.476; P = 0.016). The SA was correlated with the SL (r = 0.427; P = 0.033). The SL was also correlated with the LL (r = 0.478; P = 0.016), NRS back (r = 0.427; P = 0.033), and NRS leg (r = 0.409; P = 0.043). The LL was correlated with the NRS back (r = 0.400; P = 0.048). Cage subsidence or MC were not related to postoperative sagittal parameters (Data not shown). (Table 3)\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eSubsidence and modic change\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eModic change was classified as type 0 in 10 rhBMP-2 cases and 11 non-rhBMP-2 cases, type I in one rhBMP-2 case and two non-rhBMP-2 cases, type II in 15 rhBMP-2 cases and 12 non-rhBMP-2 cases, and type III in one rhBMP-2 case and no non-rhBMP-2 cases. Grade 1 subsidence was 0.61 \u0026plusmn; 0.23 mm in the rhBMP-2 group and 0.71 \u0026plusmn; 0.12 mm in the non-rhBMP-2 group, grade 2 subsidence was 1.47 \u0026plusmn; 0.31 mm in the rhBMP-2 group and 1.76 \u0026plusmn; 0.46 mm in the non-rhBMP-2 group, and grade 3 subsidence was 3.01 \u0026plusmn; 0.00 mm in the non-rhBMP-2 group (Table 4). Cage subsidence was positively related to the type of MC, with the most severe MC showing maximum cage subsidence. However, cage subsidence showed no difference in different types of MC, except for the normal endplate. (Figure 5)\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eClinical evaluation\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe NRS scores for back pain significantly improved 6 months postoperatively (from 6.32 \u0026plusmn; 0.73 to 2.12 \u0026plusmn; 0.81 in the rhBMP-2 group and from 6.26 \u0026plusmn; 0.79 to 2.01 \u0026plusmn; 0.29 in the non-rhBMP-2 group, 𝑃 \u0026lt; 0.05). NRS scores for leg pain also significantly increased 6 months postoperatively (from 6.32 \u0026plusmn; 0.73 to 2.04 \u0026plusmn; 0.52 in the rhBMP-2 group and from 6.01 \u0026plusmn; 0.59 to 1.78 \u0026plusmn; 0.65 in the non-rhBMP-2 group, 𝑃 \u0026lt; 0.05). The JOA score significantly improved at 1 month in both groups (from 15.28 \u0026plusmn; 5.71 to 23.09 \u0026plusmn; 2.99 for the rhBMP-2 group and from 14.57 \u0026plusmn; 2.83 to 23.65 \u0026plusmn; 0.71 for the non-rhBMP-2 group, 𝑃 \u0026lt; 0.05). SF-36 scores significantly improved at the final follow-up (from 45.49 \u0026plusmn; 3.13 to 70.22 \u0026plusmn; 5.08 in the rhBMP-2 group and from 45.99 \u0026plusmn; 5.56 to 70.33 \u0026plusmn; 5.68 in the non-rhBMP-2 group, 𝑃 \u0026lt; 0.05). (Figure 6)\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eComplications\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNo cases of intraoperative complications, such as neurological damage, postoperative alterations in sexual activity, or ejaculation-related pain were found. Different degrees of cage subsidence were found in all cases during the follow-up period. Overall, our results demonstrated a low complication rate for MIS-TLIF using rhBMP-2.\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003e\u003cstrong\u003eDose of rhBMP-2\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003erhBMP-2 has been proven to be effective in relieving donor site pain and reduce morbidity.[10] However, rhBMP-2 also shows a series of inflammatory dose-related complications, including radiculitis, osteolysis, and ectopic bone formation.[11] Owens K et al. demonstrated a modest complication rate in MIS-TLIF procedure, with rhBMP-2-associated complications occurring infrequently.[12] Even though the optimal rhBMP-2 dose in TLIF procedures remains a matter of debate, \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Villavicencio%20AT%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=27343729\"\u003eVillavicencio AT \u003c/a\u003eet al. reported that there was no correlation between the dose of rhBMP-2 and the incidence of rhBMP-2-induced radiculitis.[13] Alan T et al. confirmed the effectiveness and safety of a combination of MIS-TLIF and rhBMP-2 in lumbar fusion whereas no significant difference was found in clinical outcome between MIS-TLIF and open procedures.[13] A few years later, they adopted a wide dose range (2\u0026ndash;12 mg) of rhBMP-2. Their retrospective study did not determine the relationship between the rhBMP-2 doses and the radicular symptoms. [14] To date, the 4-6 mg/level dose of rhBMP-2 is widely adopted in clinical practice. [15] Here, our adoption of low rhBMP-2 dosage (2 mg/ level) was effective and safe in the MIS-TLIF procedures and yielded satisfactory radiological and clinical outcomes.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFusion rate\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eMany studies assessing long-term follow-up data have shown that poor bone fusion results in degeneration of the vertebral body, functional disability, lumbar spine instability, and pain. [16, 17] We observed a higher fusion rate in the rhBMP-2 group than in the non-rhBMP-2 group, which was consistent with prior studies reporting a higher fusion rate compared with autologous bone grafts. [18] \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/?term=Vaidya%20R%5BAuthor%5D\u0026amp;cauthor=true\u0026amp;cauthor_uid=17356146\"\u003eVaidya \u003c/a\u003eet al. demonstrated that radiologic signs of fusion in patients receiving allografts and rhBMP-2 appeared earlier than those in patients not receiving rhBMP-2, with the signs appearing at 6 and 19 months, respectively. However, the exact time of fusion is difficult to determine because it is unrealistic for return visit patients to undergo surgical reexploration in the short time interval after surgery. We confirmed that application of low doses of rhBMP-2 leads to a significantly different fusion rate between both groups at 3 months postoperatively. Radiographic evidence of reexploration for recurrence of pain suggests that the cage was securely fused by 8-12 weeks, which indicates that the actual process began sooner than that detected on radiography. [19]\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eSagittal parameters\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003ePrevious studies demonstrated that disc degeneration causes an increase in ADH and PDH. [20, 21] Hsieh et al. found that SL decreased at the operated segment. [22] The compensatory increase in PDH relative to the increase in ADH led to the maintenance of the SL. Biomechanical research has suggested that procedures improve the disc height and FH deficits caused by disc degeneration. [23] We found a significant increase in ADH, MDH, and PDH at the operated level in both groups. The disc height and FH in the rhBMP-2 group decreased more significantly than that in the non-rhBMP-2 group.\u003c/p\u003e\n\u003cp\u003eFurther, recent studies involving MIS-TLIF evaluated SL and presented variable results. Some reported an insufficient ability of MIS-TLIF to restore SL at the surgical level, whereas others showed substantial increases in SL. We found a significant increase in LL in patients with DLD, which was consistent with a previous study that confirmed that the interbody fusion is highly effective in improving LL.[24] Some investigators demonstrated an association between postoperative LL and better clinical outcomes.\u003c/p\u003e\n\u003cp\u003ePrevious studies evaluated short- and long-term complications associated with off-label rhBMP-2 use with TLIF. Some studies suggest that these complications may be dose-positive, and the higher the dose, the greater the probability of complications. [25] Complications and results were analyzed by BMP dose and primary versus revision surgery. Based on these results, surgical technique and rhBMP-2 dose recommendations were proposed.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eDisc height restoration\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNo consensus regarding the results of the restoration of disc height was reached. Liu et al. suggested that the improvement in disc space height plays a vital role in facet joint subluxation. [26] Kaito et al. proposed that the distraction of disc space was a potent risk factor for the progression of adjacent segment disease (ASD), which may affect clinical outcomes of patients. [27] Michael C et al. found that disc height restoration was positively associated with segmental lordosis. [28] Our results are the first to investigate the effect of rhBMP-2 in the restoration of disc height. However, even though rhBMP-2 slightly slowed down restoration of disc height and FH to some extent, we did not find any significant differences in the two groups.\u003c/p\u003e\n\u003cp\u003eBiomechanical studies have proven that diminished LL may increase the risk of ASD. [29] Kepler et al. reported that the decrease in LL was related to worse clinical outcomes, which was consistent with our results. [30] Hence, our results showed that rhBMP-2 increased postoperative SL and LL by 0.9\u0026deg; and 3.1\u0026deg;, thus improving clinical outcomes by restoring sagittal alignment. Some researchers found a relationship between restoration of LL and improvement in clinical outcomes. [31] However, the relationship between radiographic improvement and clinical outcomes was not found in the current study. Postoperative maintenance of the SL may lead to a compensatory gain of adjacent segment lordosis, which is confirmed by the correlation between the postoperative LL and the SL of the adjacent levels.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eSubsidence and MC\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eSeveral factors, including age, sex, and bone mineral density were reported to affect cage subsidence in MIS-TLIF. Tokuhashi et al. demonstrated that the average cage subsidence was 2.7 \u0026plusmn; 3.4 mm on the caudal surface and 4.0 \u0026plusmn; 2.3 mm on the cranial surface. [32] Their results were higher than those reported in the current study. The differences in cage subsidence may be attributable to the different measurement methods. CT could precisely measure the amount of subsidence during the bone remodeling process, so the average subsidence and prevalence of subsidence measured by plain radiographs were lower than those reported in other studies that used CT. David et al. reported that intact endplates increased strength and resistance to subsidence. [33] MC was associated with vertebral body structural changes such as disc herniation and vertebral endplate defect. [34] We found that cage subsidence in a different type of MC showed no significant difference except for normal endplate. Our result indicates that MC in the vertebral body may affect endplate preparation, which plays a vital role in preventing cage subsidence. However, our data did not show an improvement in cage subsidence in the rhBMP-2 group.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eClinical outcome\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eEven though all clinical outcomes improved significantly in the two groups, we found no significant difference between the groups. We demonstrated that the degrees of sagittal correction, fusion rates, and incidence of cage migration were not related with clinical outcomes in the first 12 months postoperatively. Compared with prior studies, our procedure integrated the advantages of MIS-TLIF and rhBMP-2 and confirmed that MIS-TLIF combined with rhBMP-2 is a better choice for lumbar degenerative disease.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eLimitations\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eSome limitations could not be avoided in this retrospective study. First, as the properties of L4-5 and L5-S1 are different in terms of their contribution to disc height, FH, SA, and the dimensions of the disc space, the bias resulting from the different numbers of operated levels could not be avoided. Second, our sample size was too small to obtain an accurate evaluation of the results. Third, long-term postoperative clinical assessment data were unavailable because some patients were lost to follow-up, making it impossible to reliably assess the clinical outcome of surgery. Fourth, our results did not identify the optimal rhBMP-2 dose in DLD surgeries. Prospective, randomized clinical trials are needed to determine the optimal rhBMP-2 dosage and complications.\u003c/p\u003e\n"},{"header":"Conclusions","content":"\u003cp\u003eWe conclude from this research that single-level MIS-TLIF combined with or without rhBMP-2 significantly increased the ADH, MDH, and PDH but not the SL. However, LL shows a slight but significant improvement resulting from an increase in the cranial SL. A higher fusion rate was observed in the rhBMP-2 group. However, intraoperative use of rhBMP-2 in the MIS-TLIF procedure has no effect on postoperative clinical outcomes since the NRS scores, JOA scores, and SF-36 scores in both groups were not statistically different.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cp\u003eADH: anterior disc height; MDH: middle disc height; PDH: posterior disc height ; FH: foraminal height; SA:segmental angle; SL: segmental lordosis; LL: lumbar lordosis; NRS: numeric rating scale score; JOA: Japanese Orthopedic Association scores;\u003c/p\u003e\n\u003cp\u003eSF-36: the MOS 36-item short form health survey score;\u003c/p\u003e\n\u003cp\u003eMIS-TLIF: minimally invasive transforaminal lumbar interbody fusion;\u003c/p\u003e\n\u003cp\u003erhBMP-2: recombinant human bone morphogenetic protein 2;\u003c/p\u003e\n\u003cp\u003eDLD: degenerative lumbar disease;\u003c/p\u003e\n\u003cp\u003eASD: adjacent segment disease;\u003c/p\u003e\n\u003cp\u003eMC: modic change\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eEthics approval and consent to participate\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe study was approved by the Ethics Committee of the Affiliated People's Hospital of Jiangsu University; due to the retrospective nature of the study, the need for informed consent was waived.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent for Publication\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and material\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAll data has been showed in tables and picutres.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interests: \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors declare that they have no conflict of interest.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding:\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis study was sponsored by the Clinical Medicine Science and Technology Development Foundation of Jiangsu University (Grant No: JLY20180047) and the Clinical Medicine Science and Technology Development Foundation of Jiangsu University (Grant No: JLY20180271).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthors' contributions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eBL, YTH, DL and LW conceived and designed the study; XY, JSY, and AQH performed the experiments; XY and AQH analysed the data; BL, YTH and RGC wrote the paper; AQH, JSY, and LW reviewed and edited the manuscript. BL performed major revision and minor revision. All authors read and approved the manuscript.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAcknowledgment\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWe would like to thank Dr. Xiaozheng Yang in the Shangrao People's Hospital for data collection and analytical support.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eKhan NR, Clark AJ, Lee SL, Venable GT, Rossi NB, Foley KT. Surgical Outcomes for Minimally Invasive vs Open Transforaminal Lumbar Interbody Fusion: An Updated Systematic Review and Meta-analysis. Neurosurgery. 2015;77(6):847-74; discussion 74. Epub 2015/07/28. doi: 10.1227/neu.0000000000000913. PubMed PMID: 26214320.\u003c/li\u003e\n\u003cli\u003eKimura H, Shikata J, Odate S, Soeda T, Yamamura S. Risk factors for cage retropulsion after posterior lumbar interbody fusion: analysis of 1070 cases. Spine. 2012;37(13):1164-9. Epub 2012/06/01. doi: 10.1097/BRS.0b013e318257f12a. 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PubMed PMID: 26126415.\u003c/li\u003e\n\u003cli\u003eBurkus JK, Sandhu HS, Gornet MF, Longley MC. Use of rhBMP-2 in combination with structural cortical allografts: clinical and radiographic outcomes in anterior lumbar spinal surgery. J Bone Joint Surg Am. 2005;87(6):1205-12. Epub 2005/06/03. doi: 10.2106/jbjs.d.02532. PubMed PMID: 15930528.\u003c/li\u003e\n\u003cli\u003eSethi A, Craig J, Bartol S, Chen W, Jacobson M, Coe C, et al. Radiographic and CT evaluation of recombinant human bone morphogenetic protein-2-assisted spinal interbody fusion. AJR Am J Roentgenol. 2011;197(1):W128-33. Epub 2011/06/28. doi: 10.2214/ajr.10.5484. PubMed PMID: 21700973.\u003c/li\u003e\n\u003cli\u003eTeichtahl AJ, Urquhart DM, Wang Y, Wluka AE, Heritier S, Cicuttini FM. A Dose-response relationship between severity of disc degeneration and intervertebral disc height in the lumbosacral spine. Arthritis Res Ther. 2015;17:297. Epub 2015/10/27. doi: 10.1186/s13075-015-0820-1. PubMed PMID: 26498120; PubMed Central PMCID: PMCPMC4619538.\u003c/li\u003e\n\u003cli\u003eSamartzis D, Karppinen J, Chan D, Luk KD, Cheung KM. The association of lumbar intervertebral disc degeneration on magnetic resonance imaging with body mass index in overweight and obese adults: a population-based study. Arthritis and rheumatism. 2012;64(5):1488-96. Epub 2012/01/31. doi: 10.1002/art.33462. PubMed PMID: 22287295.\u003c/li\u003e\n\u003cli\u003eHsieh PC, Koski TR, O'Shaughnessy BA, Sugrue P, Salehi S, Ondra S, et al. Anterior lumbar interbody fusion in comparison with transforaminal lumbar interbody fusion: implications for the restoration of foraminal height, local disc angle, lumbar lordosis, and sagittal balance. J Neurosurg Spine. 2007;7(4):379-86. Epub 2007/10/16. doi: 10.3171/spi-07/10/379. PubMed PMID: 17933310.\u003c/li\u003e\n\u003cli\u003eEvans JH. Biomechanics of lumbar fusion. Clin Orthop Relat Res. 1985;(193):38-46. Epub 1985/03/01. PubMed PMID: 3882295.\u003c/li\u003e\n\u003cli\u003eJagannathan J, Sansur CA, Oskouian RJ, Jr., Fu KM, Shaffrey CI. Radiographic restoration of lumbar alignment after transforaminal lumbar interbody fusion. Neurosurgery. 2009;64(5):955-63; discussion 63-4. Epub 2009/05/01. doi: 10.1227/01.neu.0000343544.77456.46. PubMed PMID: 19404155.\u003c/li\u003e\n\u003cli\u003eCarlisle P, Guda T, Silliman DT, Burdette AJ, Talley AD, Alvarez R, et al. Localized low-dose rhBMP-2 is effective at promoting bone regeneration in mandibular segmental defects. J Biomed Mater Res B Appl Biomater. 2018. Epub 2018/09/29. doi: 10.1002/jbm.b.34241. PubMed PMID: 30265782.\u003c/li\u003e\n\u003cli\u003eTian H, Wu A, Guo M, Zhang K, Chen C, Li X, et al. Adequate Restoration of Disc Height and Segmental Lordosis by Lumbar Interbody Fusion Decreases Adjacent Segment Degeneration. World Neurosurg. 2018;118:e856-e64. Epub 2018/07/22. doi: 10.1016/j.wneu.2018.07.075. PubMed PMID: 30031179.\u003c/li\u003e\n\u003cli\u003eKaito T, Hosono N, Fuji T, Makino T, Yonenobu K. Disc space distraction is a potent risk factor for adjacent disc disease after PLIF. Archives of orthopaedic and trauma surgery. 2011;131(11):1499-507. Epub 2011/06/28. doi: 10.1007/s00402-011-1343-0. PubMed PMID: 21706306.\u003c/li\u003e\n\u003cli\u003eLiebensteiner MC, Jesacher G, Thaler M, Gstoettner M, Liebensteiner MV, Bach CM. Restoration and preservation of disc height and segmental lordosis with circumferential lumbar fusion: a retrospective analysis of cage versus bone graft. Journal of spinal disorders \u0026amp; techniques. 2011;24(1):44-9. Epub 2011/01/29. doi: 10.1097/BSD.0b013e3181d67c7c. PubMed PMID: 21270626.\u003c/li\u003e\n\u003cli\u003eRothenfluh DA, Mueller DA, Rothenfluh E, Min K. Pelvic incidence-lumbar lordosis mismatch predisposes to adjacent segment disease after lumbar spinal fusion. Eur Spine J. 2015;24(6):1251-8. Epub 2014/07/16. doi: 10.1007/s00586-014-3454-0. PubMed PMID: 25018033.\u003c/li\u003e\n\u003cli\u003eKepler CK, Rihn JA, Radcliff KE, Patel AA, Anderson DG, Vaccaro AR, et al. Restoration of lordosis and disk height after single-level transforaminal lumbar interbody fusion. Orthop Surg. 2012;4(1):15-20. Epub 2012/02/01. doi: 10.1111/j.1757-7861.2011.00165.x. PubMed PMID: 22290814.\u003c/li\u003e\n\u003cli\u003eThan KD, Park P, Fu KM, Nguyen S, Wang MY, Chou D, et al. Clinical and radiographic parameters associated with best versus worst clinical outcomes in minimally invasive spinal deformity surgery. J Neurosurg Spine. 2016;25(1):21-5. Epub 2016/03/05. doi: 10.3171/2015.12.spine15999. PubMed PMID: 26943254.\u003c/li\u003e\n\u003cli\u003eTokuhashi Y, Ajiro Y, Umezawa N. Subsidence of metal interbody cage after posterior lumbar interbody fusion with pedicle screw fixation. Orthopedics. 2009;32(4). Epub 2009/04/25. PubMed PMID: 19388615.\u003c/li\u003e\n\u003cli\u003eBriski DC, Goel VK, Waddell BS, Serhan H, Kodigudla MK, Palepu V, et al. Does Spanning a Lateral Lumbar Interbody Cage Across the Vertebral Ring Apophysis Increase Loads Required for Failure and Mitigate Endplate Violation. Spine. 2017;42(20):E1158-e64. Epub 2017/05/05. doi: 10.1097/brs.0000000000002158. PubMed PMID: 28472018.\u003c/li\u003e\n\u003cli\u003eLam KS. MRI follow-up of subchondral signal abnormalities in a selected group of chronic low back pain patients. Eur Spine J. 2008;17(10):1309-10. Epub 2008/09/17. doi: 10.1007/s00586-008-0781-z. PubMed PMID: 18795340; PubMed Central PMCID: PMCPMC2556469.\u003c/li\u003e\n\u003c/ol\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e"},{"header":"Tables","content":"\u003cp style=\"margin-right: 2.35pt; line-height: 107%; text-align: left;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: #221f1f;\"\u003eTable 1. Patient baseline characteristics\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width: 396.6pt; border-collapse: collapse;\" width=\"529\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 21.0pt;\"\u003e\n\u003ctd style=\"width: 143.05pt; border: solid black 1.0pt; padding: 1.15pt 5.75pt 0in 5.3pt; height: 21.0pt;\" rowspan=\"2\" width=\"191\"\u003e\n\u003cp style=\"margin-left: .1pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: #221f1f;\"\u003eDemographic Data\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 189.85pt; border: solid black 1.0pt; border-left: none; padding: 1.15pt 5.75pt 0in 5.3pt; height: 21.0pt;\" colspan=\"2\" width=\"253\"\u003e\n\u003cp style=\"margin-left: .1pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: #2f2f2f;\"\u003eMIS-TLIF\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.7pt; border: solid black 1.0pt; border-left: none; padding: 1.15pt 5.75pt 0in 5.3pt; height: 21.0pt;\" rowspan=\"2\" width=\"85\"\u003e\n\u003cp style=\"margin-left: .3pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: #221f1f;\"\u003eP Value\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 20.5pt;\"\u003e\n\u003ctd style=\"width: 97.7pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 1.15pt 5.75pt 0in 5.3pt; height: 20.5pt;\" width=\"130\"\u003e\n\u003cp style=\"margin-left: .3pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: #221f1f;\"\u003erhBMP=25\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 1.15pt 5.75pt 0in 5.3pt; height: 20.5pt;\" width=\"123\"\u003e\n\u003cp style=\"margin-left: .4pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: #221f1f;\"\u003eNon-rhBMP=27\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 16.3pt;\"\u003e\n\u003ctd style=\"width: 143.05pt; border: solid black 1.0pt; border-top: none; padding: 1.15pt 5.75pt 0in 5.3pt; height: 16.3pt;\" width=\"191\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eAge, years \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 97.7pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 1.15pt 5.75pt 0in 5.3pt; height: 16.3pt;\" width=\"130\"\u003e\n\u003cp style=\"margin-left: .3pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e58.2\u0026plusmn;9.2 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 1.15pt 5.75pt 0in 5.3pt; height: 16.3pt;\" width=\"123\"\u003e\n\u003cp style=\"margin-left: .55pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e57.8\u0026plusmn;8.7 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.7pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 1.15pt 5.75pt 0in 5.3pt; height: 16.3pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-left: .4pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e0.779 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 16.1pt;\"\u003e\n\u003ctd style=\"width: 143.05pt; border: solid black 1.0pt; border-top: none; padding: 1.15pt 5.75pt 0in 5.3pt; height: 16.1pt;\" width=\"191\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eFemale, n (%)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 97.7pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 1.15pt 5.75pt 0in 5.3pt; height: 16.1pt;\" width=\"130\"\u003e\n\u003cp style=\"margin-left: .3pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e17/25 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 1.15pt 5.75pt 0in 5.3pt; height: 16.1pt;\" width=\"123\"\u003e\n\u003cp style=\"margin-left: .55pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e15/23 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.7pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 1.15pt 5.75pt 0in 5.3pt; height: 16.1pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-left: .4pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e0.357 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 16.1pt;\"\u003e\n\u003ctd style=\"width: 143.05pt; border: solid black 1.0pt; border-top: none; padding: 1.15pt 5.75pt 0in 5.3pt; height: 16.1pt;\" width=\"191\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eDiagnosis\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 97.7pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 1.15pt 5.75pt 0in 5.3pt; height: 16.1pt;\" width=\"130\"\u003e\n\u003cp style=\"margin-left: 2.75pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 1.15pt 5.75pt 0in 5.3pt; height: 16.1pt;\" width=\"123\"\u003e\n\u003cp style=\"margin-left: 2.95pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.7pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 1.15pt 5.75pt 0in 5.3pt; height: 16.1pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-left: .4pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e0.490 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 16.2pt;\"\u003e\n\u003ctd style=\"width: 143.05pt; border: solid black 1.0pt; border-top: none; padding: 1.15pt 5.75pt 0in 5.3pt; height: 16.2pt;\" width=\"191\"\u003e\n\u003cp style=\"margin-left: 9.95pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eSpondylolisthesis\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 97.7pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 1.15pt 5.75pt 0in 5.3pt; height: 16.2pt;\" width=\"130\"\u003e\n\u003cp style=\"margin-left: .2pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e6 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 1.15pt 5.75pt 0in 5.3pt; height: 16.2pt;\" width=\"123\"\u003e\n\u003cp style=\"margin-left: .55pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e11 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.7pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 1.15pt 5.75pt 0in 5.3pt; height: 16.2pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-left: 2.85pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 16.1pt;\"\u003e\n\u003ctd style=\"width: 143.05pt; border: solid black 1.0pt; border-top: none; padding: 1.15pt 5.75pt 0in 5.3pt; height: 16.1pt;\" width=\"191\"\u003e\n\u003cp style=\"margin-left: 9.95pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eSpinal stenosis \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 97.7pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 1.15pt 5.75pt 0in 5.3pt; height: 16.1pt;\" width=\"130\"\u003e\n\u003cp style=\"margin-left: .2pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e9 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 1.15pt 5.75pt 0in 5.3pt; height: 16.1pt;\" width=\"123\"\u003e\n\u003cp style=\"margin-left: .4pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e9 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.7pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 1.15pt 5.75pt 0in 5.3pt; height: 16.1pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-left: 2.85pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 16.1pt;\"\u003e\n\u003ctd style=\"width: 143.05pt; border: solid black 1.0pt; border-top: none; padding: 1.15pt 5.75pt 0in 5.3pt; height: 16.1pt;\" width=\"191\"\u003e\n\u003cp style=\"margin-left: 9.95pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eRecurrent disc herniation \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 97.7pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 1.15pt 5.75pt 0in 5.3pt; height: 16.1pt;\" width=\"130\"\u003e\n\u003cp style=\"margin-left: .2pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e7 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 1.15pt 5.75pt 0in 5.3pt; height: 16.1pt;\" width=\"123\"\u003e\n\u003cp style=\"margin-left: .4pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e10 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.7pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 1.15pt 5.75pt 0in 5.3pt; height: 16.1pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-left: 2.85pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 16.1pt;\"\u003e\n\u003ctd style=\"width: 143.05pt; border: solid black 1.0pt; border-top: none; padding: 1.15pt 5.75pt 0in 5.3pt; height: 16.1pt;\" width=\"191\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: #221f1f;\"\u003eLevel\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 97.7pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 1.15pt 5.75pt 0in 5.3pt; height: 16.1pt;\" width=\"130\"\u003e\n\u003cp style=\"margin-left: 2.75pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 1.15pt 5.75pt 0in 5.3pt; height: 16.1pt;\" width=\"123\"\u003e\n\u003cp style=\"margin-left: 2.95pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.7pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 1.15pt 5.75pt 0in 5.3pt; height: 16.1pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-left: .4pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e0.443 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 17.15pt;\"\u003e\n\u003ctd style=\"width: 143.05pt; border: solid black 1.0pt; border-top: none; padding: 1.15pt 5.75pt 0in 5.3pt; height: 17.15pt;\" width=\"191\"\u003e\n\u003cp style=\"margin-left: 9.95pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: #221f1f;\"\u003eL3\u0026ndash;4\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 97.7pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 1.15pt 5.75pt 0in 5.3pt; height: 17.15pt;\" width=\"130\"\u003e\n\u003cp style=\"margin-left: .15pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e2 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 1.15pt 5.75pt 0in 5.3pt; height: 17.15pt;\" width=\"123\"\u003e\n\u003cp style=\"margin-left: .4pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e2 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.7pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 1.15pt 5.75pt 0in 5.3pt; height: 17.15pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-left: 2.8pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 16.1pt;\"\u003e\n\u003ctd style=\"width: 143.05pt; border: solid black 1.0pt; border-top: none; padding: 1.15pt 5.75pt 0in 5.3pt; height: 16.1pt;\" width=\"191\"\u003e\n\u003cp style=\"margin-left: 9.95pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: #221f1f;\"\u003eL4\u0026ndash;5\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 97.7pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 1.15pt 5.75pt 0in 5.3pt; height: 16.1pt;\" width=\"130\"\u003e\n\u003cp style=\"margin-left: .4pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e21 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 1.15pt 5.75pt 0in 5.3pt; height: 16.1pt;\" width=\"123\"\u003e\n\u003cp style=\"margin-left: .4pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e19 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.7pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 1.15pt 5.75pt 0in 5.3pt; height: 16.1pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-left: 2.8pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 16.1pt;\"\u003e\n\u003ctd style=\"width: 143.05pt; border: solid black 1.0pt; border-top: none; padding: 1.15pt 5.75pt 0in 5.3pt; height: 16.1pt;\" width=\"191\"\u003e\n\u003cp style=\"margin-left: 9.95pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: #221f1f;\"\u003eL5\u0026ndash;S1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 97.7pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 1.15pt 5.75pt 0in 5.3pt; height: 16.1pt;\" width=\"130\"\u003e\n\u003cp style=\"margin-left: .15pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e3 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 1.15pt 5.75pt 0in 5.3pt; height: 16.1pt;\" width=\"123\"\u003e\n\u003cp style=\"margin-left: .4pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e7 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.7pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 1.15pt 5.75pt 0in 5.3pt; height: 16.1pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-left: 2.8pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"text-align: left; line-height: 107%; margin: 0in 0in 5.4pt .9pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: #221f1f;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .6pt; text-indent: -.5pt; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: #221f1f;\"\u003eTable 2. Clinical outcomes before and after surgery\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width: 460.45pt; border-collapse: collapse;\" width=\"614\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 16.2pt;\"\u003e\n\u003ctd style=\"width: 49.3pt; border: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.2pt;\" width=\"66\"\u003e\n\u003cp style=\"margin-left: .1pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: #221f1f;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border: solid black 1.0pt; border-left: none; padding: .75pt 3.95pt 0in 6.6pt; height: 16.2pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: .1pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: #221f1f;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border: solid black 1.0pt; border-left: none; padding: .75pt 3.95pt 0in 6.6pt; height: 16.2pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.65pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: #221f1f;\"\u003eGroup \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.9pt; border: solid black 1.0pt; border-left: none; padding: .75pt 3.95pt 0in 6.6pt; height: 16.2pt;\" width=\"104\"\u003e\n\u003cp style=\"margin-right: 2.5pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: #221f1f;\"\u003ePre-op \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border: solid black 1.0pt; border-left: none; padding: .75pt 3.95pt 0in 6.6pt; height: 16.2pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.65pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: #221f1f;\"\u003eEarly follow up \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border: solid black 1.0pt; border-left: none; padding: .75pt 3.95pt 0in 6.6pt; height: 16.2pt;\" width=\"104\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: #221f1f;\"\u003eFinal follow up \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 16.1pt;\"\u003e\n\u003ctd style=\"width: 49.3pt; border: solid black 1.0pt; border-top: none; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"66\"\u003e\n\u003cp style=\"margin-right: 2.45pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eADH\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.75pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e23 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.65pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003enon-rhBMP-2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.9pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"104\"\u003e\n\u003cp style=\"margin-right: 2.4pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e12.13\u0026plusmn;2.74\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.5pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e15.91\u0026plusmn;2.48a\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"104\"\u003e\n\u003cp style=\"margin-right: 2.5pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e12.27\u0026plusmn;3.58b\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 16.1pt;\"\u003e\n\u003ctd style=\"width: 49.3pt; border: solid black 1.0pt; border-top: none; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"66\"\u003e\n\u003cp style=\"margin-left: .1pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: #221f1f;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.75pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e25 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.65pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003erhBMP-2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.9pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"104\"\u003e\n\u003cp style=\"margin-right: 2.5pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e12.6\u0026plusmn;2.6\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.5pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e15.17\u0026plusmn;2.73a\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"104\"\u003e\n\u003cp style=\"margin-right: 2.5pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e12.18\u0026plusmn;2.61b\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 16.1pt;\"\u003e\n\u003ctd style=\"width: 49.3pt; border: solid black 1.0pt; border-top: none; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"66\"\u003e\n\u003cp style=\"margin-left: 5.9pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eMDH\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.75pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e23 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.65pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003enon-rhBMP-2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.9pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"104\"\u003e\n\u003cp style=\"margin-right: 2.4pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e10.72\u0026plusmn;2.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.5pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; 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border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"104\"\u003e\n\u003cp style=\"margin-right: 2.4pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e10.59\u0026plusmn;2.08\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.5pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e12.68\u0026plusmn;1.84a\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"104\"\u003e\n\u003cp style=\"margin-right: 2.5pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e10.70\u0026plusmn;1.69b\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 16.1pt;\"\u003e\n\u003ctd style=\"width: 49.3pt; border: solid black 1.0pt; border-top: none; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"66\"\u003e\n\u003cp style=\"margin-right: 2.55pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003ePDH\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.75pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e23 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.65pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003enon-rhBMP-2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.9pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"104\"\u003e\n\u003cp style=\"margin-right: 2.4pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e8.23\u0026plusmn;1.44\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.65pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e8.73\u0026plusmn;1.58\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"104\"\u003e\n\u003cp style=\"margin-right: 2.5pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e7.74\u0026plusmn;1.48b\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 16.2pt;\"\u003e\n\u003ctd style=\"width: 49.3pt; border: solid black 1.0pt; border-top: none; padding: .75pt 3.95pt 0in 6.6pt; height: 16.2pt;\" width=\"66\"\u003e\n\u003cp style=\"margin-left: .1pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: #221f1f;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.2pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.75pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e25 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.2pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.65pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003erhBMP-2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.9pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.2pt;\" width=\"104\"\u003e\n\u003cp style=\"margin-right: 2.4pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e7.62\u0026plusmn;1.51\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.2pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.5pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e9.36\u0026plusmn;1.54a\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.2pt;\" width=\"104\"\u003e\n\u003cp style=\"margin-right: 2.5pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e7.78\u0026plusmn;1.34b\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 16.1pt;\"\u003e\n\u003ctd style=\"width: 49.3pt; border: solid black 1.0pt; border-top: none; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"66\"\u003e\n\u003cp style=\"margin-right: 2.7pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eFH\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.75pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e23 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.65pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003enon-rhBMP-2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.9pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"104\"\u003e\n\u003cp style=\"margin-right: 2.4pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e18.50\u0026plusmn;2.72\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.65pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e19.18\u0026plusmn;2.69\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"104\"\u003e\n\u003cp style=\"margin-right: 2.65pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e17.5\u0026plusmn;2.72ab\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 16.1pt;\"\u003e\n\u003ctd style=\"width: 49.3pt; border: solid black 1.0pt; border-top: none; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"66\"\u003e\n\u003cp style=\"margin-left: .1pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: #221f1f;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.75pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e25 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.65pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003erhBMP-2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.9pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"104\"\u003e\n\u003cp style=\"margin-right: 2.4pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e18.14\u0026plusmn;2.86\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.5pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e20.55\u0026plusmn;2.10a\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"104\"\u003e\n\u003cp style=\"margin-right: 2.5pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e18.40\u0026plusmn;2.26b\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 16.1pt;\"\u003e\n\u003ctd style=\"width: 49.3pt; border: solid black 1.0pt; border-top: none; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"66\"\u003e\n\u003cp style=\"margin-right: 2.45pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eSA\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.75pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e23 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.65pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003enon-rhBMP-2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.9pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"104\"\u003e\n\u003cp style=\"margin-right: 2.4pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e8.60\u0026plusmn;4.71\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.65pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e8.38\u0026plusmn;3.11\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"104\"\u003e\n\u003cp style=\"margin-right: 2.5pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e9.33\u0026plusmn;3.46\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 16.1pt;\"\u003e\n\u003ctd style=\"width: 49.3pt; border: solid black 1.0pt; border-top: none; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"66\"\u003e\n\u003cp style=\"margin-left: .1pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: #221f1f;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.75pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e25 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.65pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003erhBMP-2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.9pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"104\"\u003e\n\u003cp style=\"margin-right: 2.4pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e9.09\u0026plusmn;3.52\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.65pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e8.33\u0026plusmn;3.07\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"104\"\u003e\n\u003cp style=\"margin-right: 2.5pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e10.12\u0026plusmn;3.76b\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 16.1pt;\"\u003e\n\u003ctd style=\"width: 49.3pt; border: solid black 1.0pt; border-top: none; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"66\"\u003e\n\u003cp style=\"margin-right: 2.45pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eSL\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.75pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e23 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.65pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003enon-rhBMP-2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.9pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"104\"\u003e\n\u003cp style=\"margin-right: 2.4pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e17.03\u0026plusmn;6.30\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.65pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e18.99\u0026plusmn;4.29\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"104\"\u003e\n\u003cp style=\"margin-right: 2.5pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e19.51\u0026plusmn;4.90*\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 16.2pt;\"\u003e\n\u003ctd style=\"width: 49.3pt; border: solid black 1.0pt; border-top: none; padding: .75pt 3.95pt 0in 6.6pt; height: 16.2pt;\" width=\"66\"\u003e\n\u003cp style=\"margin-left: .1pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.2pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.75pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e25 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.2pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.65pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003erhBMP-2 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.9pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.2pt;\" width=\"104\"\u003e\n\u003cp style=\"margin-right: 2.4pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e17.01\u0026plusmn;6.89 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.2pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.65pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e15.72\u0026plusmn;7.22 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.2pt;\" width=\"104\"\u003e\n\u003cp style=\"margin-right: 2.6pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e15.26\u0026plusmn;7.36a \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 16.1pt;\"\u003e\n\u003ctd style=\"width: 49.3pt; border: solid black 1.0pt; border-top: none; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"66\"\u003e\n\u003cp style=\"margin-right: 2.65pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eLL \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.75pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e23 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.65pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003enon-rhBMP-2 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.9pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"104\"\u003e\n\u003cp style=\"margin-right: 2.4pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e39.58\u0026plusmn;14.61 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.65pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e40.86\u0026plusmn;10.08* \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"104\"\u003e\n\u003cp style=\"margin-right: 2.5pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e44.68\u0026plusmn;11.58 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 16.1pt;\"\u003e\n\u003ctd style=\"width: 49.3pt; border: solid black 1.0pt; border-top: none; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"66\"\u003e\n\u003cp style=\"margin-left: .1pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.75pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e25 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.65pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003erhBMP-2 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.9pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"104\"\u003e\n\u003cp style=\"margin-right: 2.4pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e38.56\u0026plusmn;15.13 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.1pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"113\"\u003e\n\u003cp style=\"margin-right: 2.65pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e34.80\u0026plusmn;10.51 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 78.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: .75pt 3.95pt 0in 6.6pt; height: 16.1pt;\" width=\"104\"\u003e\n\u003cp style=\"margin-right: 2.5pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e40.7\u0026plusmn;12.88b \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin: 0in 0in .6pt .3pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"color: #221f1f;\"\u003eNote: \u003csup\u003ea\u003c/sup\u003eP \u0026lt; 0.05 vs. presurgery;\u003c/span\u003e \u003csup\u003e\u003cspan style=\"color: #221f1f;\"\u003eb\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"color: #221f1f;\"\u003eP \u0026lt; 0.05 vs early follow-up.\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 2.3pt .45pt .3pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"color: black;\"\u003e*indicates \u003c/span\u003e\u003cspan style=\"color: #221f1f;\"\u003eP \u0026lt; 0.05 between the \u003c/span\u003e\u003cspan style=\"color: black;\"\u003enon\u003c/span\u003e\u003cspan style=\"color: black;\"\u003e-rhBMP-2\u003c/span\u003e\u003cspan style=\"color: #221f1f;\"\u003e and \u003c/span\u003e\u003cspan style=\"color: black;\"\u003erhBMP-2\u003c/span\u003e\u003cspan style=\"color: #221f1f;\"\u003e groups\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-indent: -.5pt; line-height: 110%; margin: 0in 2.3pt .45pt .65pt;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 110%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-right: 63.15pt; line-height: 107%; text-align: left;\"\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp style=\"margin-right: 63.15pt; line-height: 107%; text-align: left;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eTable 3. Correlation between postoperative radiologic parameters and clinical outcomes\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width: 491.75pt; border-collapse: collapse;\" width=\"656\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 8.85pt;\"\u003e\n\u003ctd style=\"width: 28.05pt; border: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"37\"\u003e\n\u003cp style=\"margin-left: 9.85pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.4pt; border: solid black 1.0pt; border-left: none; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"margin-right: 2.1pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eADH \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border: solid black 1.0pt; border-left: none; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.95pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eMDH \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border: solid black 1.0pt; border-left: none; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.85pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003ePDH \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.85pt; border: solid black 1.0pt; border-left: none; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 2.1pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eFH \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.45pt; border: solid black 1.0pt; border-left: none; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"margin-right: 1.85pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eSA \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border: solid black 1.0pt; border-left: none; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.9pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eSL \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border: solid black 1.0pt; border-left: none; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.9pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eLL \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border: solid black 1.0pt; border-left: none; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-left: .35pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eNRS Back \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.85pt; border: solid black 1.0pt; border-left: none; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-left: 2.3pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eNRS Leg \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.7pt; border: solid black 1.0pt; border-left: none; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"73\"\u003e\n\u003cp style=\"margin-right: 1.85pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eJOA \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.45pt; border: solid black 1.0pt; border-left: none; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"margin-right: 1.95pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eSF36 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 8.85pt;\"\u003e\n\u003ctd style=\"width: 28.05pt; border-top: none; border-left: solid black 1.0pt; border-bottom: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"37\"\u003e\n\u003cp style=\"margin-left: 1.2pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eADH \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.4pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"margin-right: 1.85pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e1 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.95pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e0.660 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.95pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e0.556 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.85pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 2.05pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e0.401 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.45pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"margin-left: 1.45pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e0.168 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.95pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e0.248 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.95pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e0.075 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.85pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e-0.177 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.85pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.85pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e0.402 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.7pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"73\"\u003e\n\u003cp style=\"margin-right: 1.85pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e0.011 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.45pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"margin-left: 1.45pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e0.120 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 8.85pt;\"\u003e\n\u003ctd style=\"width: 28.05pt; border: solid black 1.0pt; border-top: none; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"37\"\u003e\n\u003cp style=\"margin-bottom: 8.0pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.4pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-left: 1.55pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.001\u0026dagger; \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-left: 1.55pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.004* \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.85pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-left: 1.45pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.047* \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.45pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"margin-left: 1.7pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.423 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.95pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.231 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.95pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.720 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.95pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.396 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.85pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-left: 1.55pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.046* \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.7pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"73\"\u003e\n\u003cp style=\"margin-right: 1.85pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.959 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.45pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"margin-left: 1.7pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.567 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 8.85pt;\"\u003e\n\u003ctd style=\"width: 28.05pt; border-top: none; border-left: solid black 1.0pt; border-bottom: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"37\"\u003e\n\u003cp style=\"margin-left: .5pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eMDH \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.4pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.85pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e1 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.95pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e0.656 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.85pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 2.05pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e0.267 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.45pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"margin-left: .1pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e-0.157 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.95pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e0.304 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.85pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e-0.040 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.85pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e-0.364 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.85pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.85pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e0.169 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.7pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"73\"\u003e\n\u003cp style=\"margin-right: 1.95pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e-0.167 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.45pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"margin-left: 1.45pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e0.376 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 8.85pt;\"\u003e\n\u003ctd style=\"width: 28.05pt; border: solid black 1.0pt; border-top: none; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"37\"\u003e\n\u003cp style=\"margin-bottom: 8.0pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.4pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.001\u0026dagger; \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.85pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 2.05pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.196 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.45pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"margin-left: 1.7pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.454 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.95pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.139 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.95pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.850 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.95pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.074 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.85pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.85pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.418 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.7pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"73\"\u003e\n\u003cp style=\"margin-right: 1.85pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.426 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.45pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"margin-left: 1.7pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.064 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 8.85pt;\"\u003e\n\u003ctd style=\"width: 28.05pt; border-top: none; border-left: solid black 1.0pt; border-bottom: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"37\"\u003e\n\u003cp style=\"margin-left: 1.8pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003ePDH \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.4pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.8pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e1 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.85pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 2.05pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e0.449 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.45pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"margin-left: .1pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e-0.116 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.95pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e0.138 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.85pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e-0.061 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.85pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e-0.146 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.85pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.85pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e0.258 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.7pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"73\"\u003e\n\u003cp style=\"margin-right: 1.95pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e-0.089 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.45pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"margin-left: 1.45pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e0.222 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 8.85pt;\"\u003e\n\u003ctd style=\"width: 28.05pt; border: solid black 1.0pt; border-top: none; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"37\"\u003e\n\u003cp style=\"margin-bottom: 8.0pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.4pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.85pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-left: 1.45pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.024* \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.45pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"margin-left: 1.7pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.580 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.95pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.511 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.95pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.773 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.95pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.486 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.85pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.85pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.214 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.7pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"73\"\u003e\n\u003cp style=\"margin-right: 1.85pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.673 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.45pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"margin-left: 1.7pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.287 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 8.85pt;\"\u003e\n\u003ctd style=\"width: 28.05pt; border-top: none; border-left: solid black 1.0pt; border-bottom: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"37\"\u003e\n\u003cp style=\"margin-right: 2.1pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eFH \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.4pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.85pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.95pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e1 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.45pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"margin-left: .1pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e-0.153 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.95pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e0.024 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.85pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e-0.172 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.95pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e0.188 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.85pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.85pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e0.476 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.7pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"73\"\u003e\n\u003cp style=\"margin-right: 1.85pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e0.200 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.45pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"margin-left: 1.45pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e0.109 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 8.85pt;\"\u003e\n\u003ctd style=\"width: 28.05pt; border: solid black 1.0pt; border-top: none; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"37\"\u003e\n\u003cp style=\"margin-bottom: 8.0pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.4pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.85pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: .1pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.45pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"margin-left: 1.7pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.465 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.95pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.909 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.95pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.410 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.95pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.367 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.85pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-left: 1.55pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.016* \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.7pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"73\"\u003e\n\u003cp style=\"margin-right: 1.85pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.337 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.45pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"margin-left: 1.7pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.604 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 8.85pt;\"\u003e\n\u003ctd style=\"width: 28.05pt; border-top: none; border-left: solid black 1.0pt; border-bottom: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"37\"\u003e\n\u003cp style=\"margin-right: 1.95pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eSA \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.4pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.85pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: .1pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.45pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"margin-right: 1.8pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e1 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.75pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e0.427\u003csup\u003e*\u003c/sup\u003e \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.95pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e0.640 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.95pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e-0.102 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.85pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.7pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e-0.150 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.7pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"73\"\u003e\n\u003cp style=\"margin-right: 1.85pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e0.327 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.45pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"margin-left: 1.45pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e0.008 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 8.85pt;\"\u003e\n\u003ctd style=\"width: 28.05pt; border: solid black 1.0pt; border-top: none; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"37\"\u003e\n\u003cp style=\"margin-bottom: 8.0pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.4pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.85pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: .1pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.45pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-left: 1.55pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.033* \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.95pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.001 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.95pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.627 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.85pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.85pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.474 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.7pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"73\"\u003e\n\u003cp style=\"margin-right: 1.85pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.110 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.45pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"margin-left: 1.7pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.970 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 8.85pt;\"\u003e\n\u003ctd style=\"width: 28.05pt; border-top: none; border-left: solid black 1.0pt; border-bottom: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"37\"\u003e\n\u003cp style=\"margin-right: 1.8pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eSL \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.4pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.85pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: .1pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.45pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.8pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e1 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.9pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e.478\u003csup\u003e*\u003c/sup\u003e \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.85pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e-0.427 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.85pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.7pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e-0.409 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.7pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"73\"\u003e\n\u003cp style=\"margin-right: 1.95pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e-0.217 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.45pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"margin-left: .1pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e-0.041 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 8.85pt;\"\u003e\n\u003ctd style=\"width: 28.05pt; border: solid black 1.0pt; border-top: none; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"37\"\u003e\n\u003cp style=\"margin-bottom: 8.0pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.4pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.85pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: .1pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.45pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-left: 1.55pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.016* \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-left: 1.55pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.033* \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.85pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-left: 1.55pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.043* \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.7pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"73\"\u003e\n\u003cp style=\"margin-right: 1.85pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.298 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.45pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"margin-left: 1.7pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.846 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 8.85pt;\"\u003e\n\u003ctd style=\"width: 28.05pt; border-top: none; border-left: solid black 1.0pt; border-bottom: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"37\"\u003e\n\u003cp style=\"margin-right: 2.0pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eLL \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.4pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.85pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: .1pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.45pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.8pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e1 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.85pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e-0.400 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.85pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.7pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e-0.094 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.7pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"73\"\u003e\n\u003cp style=\"margin-right: 1.85pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e0.112 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.45pt; border: none; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"margin-left: 1.45pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e0.135 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 8.85pt;\"\u003e\n\u003ctd style=\"width: 28.05pt; border: solid black 1.0pt; border-top: none; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"37\"\u003e\n\u003cp style=\"margin-bottom: 8.0pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.4pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.85pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: .1pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.45pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-left: 1.55pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.048* \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.85pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-right: 1.85pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.654 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.7pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"73\"\u003e\n\u003cp style=\"margin-right: 1.85pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.595 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.45pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 8.85pt;\" width=\"51\"\u003e\n\u003cp style=\"margin-left: 1.7pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.520 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 17.8pt;\"\u003e\n\u003ctd style=\"width: 28.05pt; border: solid black 1.0pt; border-top: none; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.8pt;\" width=\"37\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; margin: 0in 0in 5.55pt 2.05pt;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eNRS \u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-left: 1.55pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eBack \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.4pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.8pt;\" width=\"51\"\u003e\n\u003cp style=\"margin-bottom: 6.15pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.8pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-bottom: 6.15pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.8pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-bottom: 6.15pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.85pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.8pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; margin: 0in .1pt 6.15pt 0in;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-right: .1pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.45pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.8pt;\" width=\"51\"\u003e\n\u003cp style=\"margin-bottom: 6.15pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.8pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-bottom: 6.15pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.8pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-bottom: 6.15pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.8pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; margin: 0in 1.8pt 6.15pt 0in;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e1 \u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.85pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.8pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; margin: 0in 1.8pt 6.6pt 0in;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e0.288 \u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-right: 1.85pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.162 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.7pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.8pt;\" width=\"73\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; margin: 0in 1.85pt 6.65pt 0in;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e0.229 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-right: 1.85pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.271 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.45pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.8pt;\" width=\"51\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; margin: 0in 0in 6.65pt 1.45pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e0.045 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-left: 1.7pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.831 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 17.75pt;\"\u003e\n\u003ctd style=\"width: 28.05pt; border: solid black 1.0pt; border-top: none; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.75pt;\" width=\"37\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; margin: 0in 0in 5.55pt 2.05pt;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eNRS \u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-right: 1.95pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eLeg \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.4pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.75pt;\" width=\"51\"\u003e\n\u003cp style=\"margin-bottom: 6.0pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.75pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-bottom: 6.0pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.75pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-bottom: 6.0pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.85pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.75pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; margin: 0in .1pt 6.0pt 0in;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-right: .1pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.45pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.75pt;\" width=\"51\"\u003e\n\u003cp style=\"margin-bottom: 6.0pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.75pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-bottom: 6.0pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.75pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-bottom: 6.0pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.75pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-bottom: 6.0pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.85pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.75pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; margin: 0in 1.7pt 6.0pt 0in;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e1 \u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-left: .15pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.7pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.75pt;\" width=\"73\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; margin: 0in 1.95pt 6.5pt 0in;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e-0.047 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-right: 1.85pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.823 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.45pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.75pt;\" width=\"51\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; margin: 0in 0in 6.5pt 1.45pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e0.068 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-left: 1.7pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.746 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 17.75pt;\"\u003e\n\u003ctd style=\"width: 28.05pt; border: solid black 1.0pt; border-top: none; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.75pt;\" width=\"37\"\u003e\n\u003cp style=\"margin-left: 2.5pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eJOA \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.4pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.75pt;\" width=\"51\"\u003e\n\u003cp style=\"margin-bottom: 6.0pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.75pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-bottom: 6.0pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.75pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-bottom: 6.0pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.85pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.75pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; margin: 0in .1pt 6.0pt 0in;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-right: .1pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.45pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.75pt;\" width=\"51\"\u003e\n\u003cp style=\"margin-bottom: 6.0pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.75pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-bottom: 6.0pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.75pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-bottom: 6.0pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.75pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-bottom: 6.0pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.85pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.75pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; margin: 0in 0in 6.0pt .15pt;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-left: .15pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.7pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.75pt;\" width=\"73\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; margin: 0in 1.9pt 6.0pt 0in;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e1 \u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-left: .15pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.45pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.75pt;\" width=\"51\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%; margin: 0in 0in 6.5pt 1.45pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003eR\u003c/span\u003e\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 107%; color: black; background: #ffffed;\"\u003e=\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e0.262 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-left: 1.7pt; text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e𝑃\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e=0.206 \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 17.6pt;\"\u003e\n\u003ctd style=\"width: 28.05pt; border: solid black 1.0pt; border-top: none; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.6pt;\" width=\"37\"\u003e\n\u003cp style=\"text-align: left; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eSF-36 \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.4pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.6pt;\" width=\"51\"\u003e\n\u003cp style=\"margin-bottom: 6.15pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.6pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-bottom: 6.15pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.6pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-bottom: 6.15pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.85pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.6pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; margin: 0in .1pt 6.15pt 0in;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-right: .1pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.45pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.6pt;\" width=\"51\"\u003e\n\u003cp style=\"margin-bottom: 6.15pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.6pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-bottom: 6.15pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.6pt;\" width=\"56\"\u003e\n\u003cp style=\"margin-bottom: 6.15pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 42.0pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.6pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; margin: 0in 0in 6.15pt .05pt;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.85pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.6pt;\" width=\"56\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; margin: 0in 0in 6.15pt .15pt;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-left: .15pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.7pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.6pt;\" width=\"73\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; margin: 0in 0in 6.15pt .15pt;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-left: .15pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 38.45pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 2.4pt 3.5pt 0in 5.4pt; height: 17.6pt;\" width=\"51\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%; margin: 0in 1.8pt 6.15pt 0in;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e1 \u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"text-align: left; line-height: 107%; margin: 0in 0in .6pt .9pt;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: #221f1f;\"\u003e\u0026nbsp;\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: #221f1f;\"\u003e*Statistically significant values at the 0.05 level, by Pearson correlation coefficient. \u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: left; text-indent: -.5pt; line-height: 107%; margin: 0in 0in .6pt .65pt;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: #221f1f;\"\u003e\u0026dagger;Statistically significant values at the 0.001 level, by Pearson correlation coefficient. \u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp style=\"margin-right: 2.35pt; line-height: 107%; text-align: left;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eTable 4 Modic change and cage subsidence data in different groups\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"width: 325.95pt; border-collapse: collapse;\" width=\"435\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.8pt;\"\u003e\n\u003ctd style=\"width: 60.7pt; border: solid black 1.0pt; padding: 0in 5.75pt 0in 5.75pt; height: 19.8pt;\" width=\"81\"\u003e\n\u003cp style=\"margin-left: 3.0pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 102.25pt; border: solid black 1.0pt; border-left: none; padding: 0in 5.75pt 0in 5.75pt; height: 19.8pt;\" width=\"136\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003erhBMP-2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 103.75pt; border: solid black 1.0pt; border-left: none; padding: 0in 5.75pt 0in 5.75pt; height: 19.8pt;\" width=\"138\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003enon-rhBMP-2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 59.25pt; border: solid black 1.0pt; border-left: none; padding: 0in 5.75pt 0in 5.75pt; height: 19.8pt;\" width=\"79\"\u003e\n\u003cp style=\"margin-right: .3pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cem\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003eP \u003c/span\u003e\u003c/em\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003evalue\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 19.8pt;\"\u003e\n\u003ctd style=\"width: 60.7pt; border: solid black 1.0pt; border-top: none; padding: 0in 5.75pt 0in 5.75pt; height: 19.8pt;\" width=\"81\"\u003e\n\u003cp style=\"margin-left: .1pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eModic 0\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 102.25pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 0in 5.75pt 0in 5.75pt; height: 19.8pt;\" width=\"136\"\u003e\n\u003cp style=\"margin-right: .1pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e10\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 103.75pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 0in 5.75pt 0in 5.75pt; height: 19.8pt;\" width=\"138\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e11\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 59.25pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 0in 5.75pt 0in 5.75pt; height: 19.8pt;\" width=\"79\"\u003e\n\u003cp style=\"margin-right: .25pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e0.046\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 19.8pt;\"\u003e\n\u003ctd style=\"width: 60.7pt; border: solid black 1.0pt; border-top: none; padding: 0in 5.75pt 0in 5.75pt; height: 19.8pt;\" width=\"81\"\u003e\n\u003cp style=\"margin-left: .1pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eModic 1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 102.25pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 0in 5.75pt 0in 5.75pt; height: 19.8pt;\" width=\"136\"\u003e\n\u003cp style=\"margin-right: .1pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 103.75pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 0in 5.75pt 0in 5.75pt; height: 19.8pt;\" width=\"138\"\u003e\n\u003cp style=\"margin-right: .1pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 59.25pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 0in 5.75pt 0in 5.75pt; height: 19.8pt;\" width=\"79\"\u003e\n\u003cp style=\"margin-right: .15pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e/\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 19.9pt;\"\u003e\n\u003ctd style=\"width: 60.7pt; border: solid black 1.0pt; border-top: none; padding: 0in 5.75pt 0in 5.75pt; height: 19.9pt;\" width=\"81\"\u003e\n\u003cp style=\"margin-left: .1pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eModic 2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 102.25pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 0in 5.75pt 0in 5.75pt; height: 19.9pt;\" width=\"136\"\u003e\n\u003cp style=\"margin-right: .1pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e15\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 103.75pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 0in 5.75pt 0in 5.75pt; height: 19.9pt;\" width=\"138\"\u003e\n\u003cp style=\"margin-right: .1pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e12\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 59.25pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 0in 5.75pt 0in 5.75pt; height: 19.9pt;\" width=\"79\"\u003e\n\u003cp style=\"margin-right: .25pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e0.591\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 19.8pt;\"\u003e\n\u003ctd style=\"width: 60.7pt; border: solid black 1.0pt; border-top: none; padding: 0in 5.75pt 0in 5.75pt; height: 19.8pt;\" width=\"81\"\u003e\n\u003cp style=\"margin-left: .1pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eModic 3\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 102.25pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 0in 5.75pt 0in 5.75pt; height: 19.8pt;\" width=\"136\"\u003e\n\u003cp style=\"margin-right: .1pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 103.75pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 0in 5.75pt 0in 5.75pt; height: 19.8pt;\" width=\"138\"\u003e\n\u003cp style=\"margin-right: .1pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 59.25pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 0in 5.75pt 0in 5.75pt; height: 19.8pt;\" width=\"79\"\u003e\n\u003cp style=\"margin-right: .15pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e/\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 39.05pt;\"\u003e\n\u003ctd style=\"width: 60.7pt; border: solid black 1.0pt; border-top: none; padding: 0in 5.75pt 0in 5.75pt; height: 39.05pt;\" width=\"81\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eGrade 1\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 102.25pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 0in 5.75pt 0in 5.75pt; height: 39.05pt;\" width=\"136\"\u003e\n\u003cp style=\"margin-left: .15pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e0.61\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e0.23\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 103.75pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 0in 5.75pt 0in 5.75pt; height: 39.05pt;\" width=\"138\"\u003e\n\u003cp style=\"margin-left: .1pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e0.71\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e0.12\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 59.25pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 0in 5.75pt 0in 5.75pt; height: 39.05pt;\" width=\"79\"\u003e\n\u003cp style=\"margin-right: .25pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e0.295\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 39.05pt;\"\u003e\n\u003ctd style=\"width: 60.7pt; border: solid black 1.0pt; border-top: none; padding: 0in 5.75pt 0in 5.75pt; height: 39.05pt;\" width=\"81\"\u003e\n\u003cp style=\"text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003eGrade 2\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 102.25pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 0in 5.75pt 0in 5.75pt; 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border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 0in 5.75pt 0in 5.75pt; height: 39.05pt;\" width=\"136\"\u003e\n\u003cp style=\"margin-right: .05pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e/\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 103.75pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 0in 5.75pt 0in 5.75pt; height: 39.05pt;\" width=\"138\"\u003e\n\u003cp style=\"margin-left: .15pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; font-family: verdana, geneva;\"\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e3.01\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e\u0026plusmn;\u003c/span\u003e\u003cspan style=\"line-height: 107%; color: black;\"\u003e0.00\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 59.25pt; border-top: none; border-left: none; border-bottom: solid black 1.0pt; border-right: solid black 1.0pt; padding: 0in 5.75pt 0in 5.75pt; height: 39.05pt;\" width=\"79\"\u003e\n\u003cp style=\"margin-right: .15pt; text-align: center; line-height: 107%;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 107%; font-family: verdana, geneva; color: black;\"\u003e/\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"text-indent: -.5pt; line-height: 110%; margin: 0in 2.3pt .45pt .65pt;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 110%; font-family: verdana, geneva; color: black;\"\u003e* Statistically significant among groups. \u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-indent: -.5pt; line-height: 110%; margin: 0in 2.3pt .45pt .65pt;\"\u003e\u003cspan style=\"font-size: 10pt; line-height: 110%; font-family: verdana, geneva; color: black;\"\u003e\u0026dagger; Values are presented as means \u0026plusmn; SD. \u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF), Bone morphogenetic protein, rhBMP-2, Degenerative lumbar disease, Radiographic outcome.","lastPublishedDoi":"10.21203/rs.2.12544/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.2.12544/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"Background: The combination of minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) and recombinant human bone morphogenetic protein 2 (rhBMP-2) is widely used for its advantage of rapid recovery and improved bone fusion. However, no previous study has reported the synergistic effect of MIS-TLIF with rhBMP-2 in patients with degenerative lumbar disease (DLD).\nObjective: To investigate the radiographic and patient-reported outcomes (PROs) in patients with DLD who underwent MIS-TLIF with and without a low dose of rhBMP-2.\nMethods: We retrospectively reviewed 48 patients treated with MIS-TLIF from 2013 to 2016. The patients were classified into the rhBMP-2 group (n = 25) and non-rhBMP-2 group (n = 23). Fusion-related parameters were measured before and after the operation. Clinical data included the numeric rating scale (NRS) score, Japanese Orthopedic Association (JOA) scores, and the MOS 36-item short form health survey (SF-36) score, which were documented to evaluate the effect of surgery.\nResults: In the 48 patients who underwent MIS-TLIF, the operated disc was predominantly at the L4/5 and L5/S1 levels. ADH, MDH, and PDH increased significantly in both groups after surgery (P \u003c 0.05). FH improved in the rhBMP-2 group, but not in the non-rhBMP-2 group. There was no obvious improvement in SA in both groups. Furthermore, the SL showed a significant difference in both groups and a significant improvement over the baseline. The LL showed significant improvement in the two groups at the early follow-up (P \u003c 0.05), but the improvement did not persist. Cage subsidence had no significant effect on different subsidence grades. In addition, no differences in cage subsidence were observed in different types of modic change (MC), except for MC 0 in both groups. There was no difference in PROs even though all clinical outcomes improved significantly during the postoperative follow-up period in both groups.\nConclusion: MIS-TLIF with the low doses of rhBMP-2 resulted in an improvement in radiographic and clinical results, but not a longer-lasting restoration for radiographic outcomes. Cage subsidence is not associated with the MC. Further, our clinical data demonstrated no difference between both groups.","manuscriptTitle":"Evaluations of minimally invasive transforaminal lumbar interbody fusion performed with rhBMP-2","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2019-08-09 01:54:58","doi":"10.21203/rs.2.12544/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"52043132-5ae4-48b8-83a9-315454844e7b","owner":[],"postedDate":"August 9th, 2019","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":20184,"name":"Orthopedics"}],"tags":[],"updatedAt":"","versionOfRecord":[],"versionCreatedAt":"2019-08-09 01:54:58","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-3300","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"identity":"rs-3300","version":["v1"]},"buildId":"FbvkV6FR0MCFSLy54lSbu","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}