SYNGR2 Serves as a Prognostic Biomarker and Correlated with Immune Infiltrates in Esophageal Squamous Cell Carcinoma

Background: Synaptogyrin-2 (SYNGR2) plays an important role in regulating membrane traffic in non-neuronal cells. However, the role of SYNGR2 in esophageal squamous cell carcinoma (ESCC) remains unclear. Methods: : All original data were downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases and integrated via R 3.5.3. SYNGR2 expression was explored with TCGA and GEO databases. The correlations between SYNGR2 and cancer immune characteristics were analyzed via the TIMER and TISIDB databases. Results: : In general, SYNGR2 is predominantly overexpressed and has reference value in the diagnosis and prognostic estimation of ESCC. Upregulated SYNGR2 was associated with poorer overall survival, poorer disease-specific survival and T stage in ESCC. Mechanistically, we identified a hub gene that included a total of 38 SYNGR2-related genes, which were tightly associated with the protein polyubiquitination pathway in ESCC patients. SYNGR2 expression was negatively related to the infiltrating levels of T helper cells. SYNGR2 methylation was positively correlated with the expression of chemokines (CCL2 and CXCL12), chemokine receptors (CCR1 and CCR2), Immunoinhibitors (CXCL12 and TNFRSF4) and Immunostimulators (CSF1R and PDCD1LG2) in ESCC. Conclusion: SYNGR2 may can be used as a biomarker for determining the prognosis and immune infiltration in ESCC.