Effectiveness of Single Dose Premedication of Piroxicam and Prednisolone on Post Endodontic Pain in One Visit Root Canal Treatment: A Randomized Trial

Effectiveness of Single Dose Premedication of Piroxicam and Prednisolone on Post Endodontic Pain in One Visit Root Canal Treatment: A Randomized Trial | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Effectiveness of Single Dose Premedication of Piroxicam and Prednisolone on Post Endodontic Pain in One Visit Root Canal Treatment: A Randomized Trial DR ANUM TANWIR, DR SHAHBAZ AHMED, DR HIRA AKHTAR, DR UMAIR WAHID, and 2 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-278989/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract BACKGROUND Many approaches have been investigated for pain relief after root canal procedure. In this study we compare the effectiveness of premedication drugs, given single dose Piroxicam and Prednisolone separately to evaluate post endodontic pain at different time intervals (24, 48, 72 and 96 hours) using visual analog scale (VAS) after single visit root canal treatment. METHODS Total number of 120 patients identified with symptomatic irreversible pulpitis were made part of this research after signing informed consent. The pain intensity levels were marked through the use of VAS scale before the commencement of treatment. The participants were randomly placed in three groups (n=40) Group I: Control, Group II: Piroxicam (20 mg) and Group III: Prednisolone (20 mg). The drugs were administered thirty minutes before endodontic procedure was initiated. Root canal procedure was carried out followed by placement of provisional restoration on a single appointment. The patients were advised to continue marking their pain intensity levels after 24, 48, 72 and 96 hours using VAS. All patients were called for follow up after 4 days for clinical evaluation and placement of permanent restoration. The effectiveness of each drug over different time interval was studied employing repeated measure ANOVA. The significance level was considered p-value <0.05. RESULTS Administration of pre-medication drug therapy with Piroxicam and Prednisolone was able to successfully alleviate post-endodontic pain. However, the long term effectiveness (96 hours) of both drugs to reduce post-endodontic pain was observed to be statistically insignificant. CONCLUSION Pre-medication with either single dose Piroxicam and Prednisolone was found to be effective against post-endodontic pain, in patients presenting with symptomatic irreversible pulpitis. TRIAL REGISTRATION: This single blinded, randomized clinical trial [registration no. NCT04124822(11/10/2019)] was performed in Operative Dentistry department of Dr. Ishrat-ul-Ebad Khan Institute of Oral Health Sciences. Dentistry Piroxicam Prednisolone Post-endodontic pain Pre-medication Figures Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-278989","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":15036027,"identity":"46cc09ba-4063-4e45-8479-dca87c8715a4","order_by":0,"name":"DR ANUM TANWIR","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA20lEQVRIiWNgGAWjYFADZgbGB0CKh4845QlgLcwGIC1sxGthYGCTAJOEFPPP7jHdwPjDLs/gOO+zyq85djJsDMwPH93Ao0XizhmzGwwJycUGh9nNbstuSwY6jM3YOAefNTdyQFqYE7cdZmO7LbmNGaiFh00anxZ5iJZ6sJZiyW31hLUYQLQcBmth/LjtMGEthjfSym4kpB1P3H+YjVmacdtxHjZmAn6Ru5G87cYHm+rEmf3HGD/+3FZtz8/e/PAxXu+DQAKUZuYBk4SUIwPGH6SoHgWjYBSMghEDAPiPQzoempZqAAAAAElFTkSuQmCC","orcid":"","institution":"Dow University of Health Sciences","correspondingAuthor":true,"submittingAuthor":false,"prefix":"DR","firstName":"ANUM","middleName":"","lastName":"TANWIR","suffix":""},{"id":15036028,"identity":"89b4a121-cb0e-406c-b680-126fab547939","order_by":1,"name":"DR SHAHBAZ AHMED","email":"","orcid":"","institution":"Dow University of Health 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is available for \u003ca href='/article/rs-278989/latest.pdf' target='_blank'\u003edownload as a PDF\u003c/a\u003e.\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research 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In this study we compare the effectiveness of premedication drugs, given single dose Piroxicam and Prednisolone separately to evaluate post endodontic pain at different time intervals (24, 48, 72 and 96 hours) using visual analog scale (VAS) after single visit root canal treatment.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eMETHODS\u003c/strong\u003e\u003c/p\u003e\u003cp\u003eTotal number of 120 patients identified with symptomatic irreversible pulpitis were made part of this research after signing informed consent. The pain intensity levels were marked through the use of VAS scale before the commencement of treatment. The participants were randomly placed in three groups (n=40) Group I: Control, Group II: Piroxicam (20 mg) and Group III: Prednisolone (20 mg). The drugs were administered thirty minutes before endodontic procedure was initiated. Root canal procedure was carried out followed by placement of provisional restoration on a single appointment. 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However, the long term effectiveness (96 hours) of both drugs to reduce post-endodontic pain was observed to be statistically insignificant.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eCONCLUSION\u003c/strong\u003e\u003c/p\u003e\u003cp\u003ePre-medication with either single dose Piroxicam and Prednisolone was found to be effective against post-endodontic pain, in patients presenting with symptomatic irreversible pulpitis.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eTRIAL REGISTRATION:\u003c/strong\u003e This single blinded, randomized clinical trial [registration no. NCT04124822(11/10/2019)] was performed in Operative Dentistry department of Dr. Ishrat-ul-Ebad Khan Institute of Oral Health Sciences.\u003c/p\u003e","manuscriptTitle":"Effectiveness of Single Dose Premedication of Piroxicam and Prednisolone on Post Endodontic Pain in One Visit Root Canal Treatment: A Randomized Trial","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2021-03-15 16:49:01","doi":"10.21203/rs.3.rs-278989/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"356c9fef-0167-4fe1-8a2d-9c9240f8dfbd","owner":[],"postedDate":"March 15th, 2021","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":2950196,"name":"Dentistry"}],"tags":[],"updatedAt":"2021-03-19T12:44:16+00:00","versionOfRecord":[],"versionCreatedAt":"2021-03-15 16:49:01","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-278989","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-278989","identity":"rs-278989","version":["v1"]},"buildId":"FbvkV6FR0MCFSLy54lSbu","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}