卵巢癌MMP-2、MMP-9和VEGF-C表达与其生物学行为的关系

Objective: To explore the association of the expression of MMP-2, MMP-9 and VEGF-C with the clinicobiologic behavior in ovarian carcinoma. Methods: Immunohistochemical staining was used to detect the expression of MMP-2, MMP-9 and VEGF-C in 97 cases of ovarian cancer. Results: The positive expression of MMP-2, MMP-9 and VEGF-C had no relationship with histological typing of ovarian carcinoma (P＞0.05). But the expressions of the three markers were higher in clinical stage Ⅰ, Ⅱ than that in stage Ⅲ, Ⅳ (P＜0.005 to P＜0.05), and which were increased with the grading (P＜0.005 to P＜0.05). And the expressions were higher in patients with lymph node involvement than those without ones (P＜0.05 to P＜0.005). In ovarian carcinoma, the expression VEGF-C had positive direct correlation to both the expression of MMP-2 and MMP-9 (P＜0.05). Conclusions: The expression of MMP-2 and MMP-9 with cooperative of VEGF-C promote invasion and metastasis of ovarian carcinomas, and thus can be used as markers to predict invasion and metastasis of ovarian carcinomas and the prognosis of these patients as well.