LRP16、E-cadherin、ER与PR在子宫内膜异位症中的表达及其意义

Objective To study the expression of LRP16 and E-cadherin (E-cad), ER, PR in eutopic endometrium and ectopic endometrium of endometriosis (EM), as well as to study the relation one another and the possible clinical significance. Methods The expression of LRP16 and E cadherin, ER, PR in endometrium was detected by immunohistochemical two step staining methods in 72 patients with endometriosis which was finally confirmed by laparoscopic operation. Results The expression of LRP16 in epithelioglandular endochylema in eutopic endometrium of EM was significantly higher than that in ectopic endometrium (P＜0.05), while no significant difference was found between expression level of LRP16 in epithelioglandular nucleus of eutopic endometrium and ectopic endometrium. The expression of E-cad in ectopic endometrium of EM patients was higher than in eutopic endometrium (P＜0.05). No significant correlation existed between LRP16 and E-cad in both eutopic and ectopic endometrium. The expression of ER and PR in epithelioglandular nucleus in en topic endometrium of EM patients was higher than in that 0f ectopic endometrium (P＜0.05). The expression of PR was higher than the expression of LRP16 in ectopic endometrium of EM patients (P＜0.05), the expression of ER was lower than the expression of LRP16 in ectopic endometrium of EM patients (P＜0.05), and the expression of ER was correlated with LRP16 in epithelioglandular nucleus of ectopic endometrium. The expression of both ER and PR was lower than that of LRP16 in eutopic endometrium of EM patients (P＜0.05). Conclusion The expression levels of LRP16, ER, PR and E-cad in epithelioglandular endochylema and nucleus were different in ectopic and eutopic endometrium of EM patients, and this abnormal expression may be correlated with pathogenesis and development of endometriosis.