[Retroperitoneal endometriosis : When a rare form of endometriosis becomes a urological disease].

article OA: closed CC0
AI-generated summary by claude@2026-06, 2026-06-07

Retroperitoneal endometriosis, a benign condition affecting the ureters and bladder, requires an interdisciplinary approach with surgical excision as the gold standard therapy for symptomatic involvement.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text

The paper discusses retroperitoneal endometriosis from a urological perspective, describing its symptoms and proposed pathogenesis and providing an overview of diagnosis and current guideline-based therapy options. It summarizes that ureteral and urinary bladder involvement can occur, with ureter involvement causing hydronephrosis representing an absolute indication for therapy, and recurrent macrohematuria from bladder involvement potentially requiring treatment. The authors state that surgical excision of clinically significant endometriosis foci is the first-line “gold standard,” with minimally invasive approaches preferred when feasible and medication considered secondary. This paper is centrally about endometriosis — specifically retroperitoneal endometriosis involving the ureters and bladder.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

BACKGROUND: Retroperitoneal endometriosis is a common benign disease, which requires an interdisciplinary approach. In the clinical practice diagnosis is often delayed for years after onset of the unspecific symptoms so that increased awareness is necessary for detection of the presence of the disease. OBJECTIVE: This article provides a description of the disease including the symptoms and pathogenesis, an introduction to the complexity of diagnostic investigations and the current therapy recommendations. MATERIAL AND METHODS: Comparison of current therapy recommendations according to the guidelines under consideration of individual studies and background research. Assessment of studies and the accompanying interpretations with the intention of presenting an introduction to the topic with therapy recommendations. RESULTS: From a urological point of view retroperitoneal endometriosis is a benign disease affecting the ureters and urinary bladder. Involvement of the ureters leading to hydronephrosis caused by ureteral compression represents an absolute indication for therapy. Recurrent macrohematuria can also necessitate treatment. Treatment includes surgical excision of the focal point of endometriosis as the first line therapy. Various operative procedures and access routes are available but when possible a minimally invasive procedure should be used. A second line drug therapy is also possible. CONCLUSION: Surgical excision of a clinically significant focus of endometriosis is the gold standard for therapy. This procedure should take place in a specialized center within an interdisciplinary consensus. Due to the fact that endometriosis is primarily a benign disease, medical clarification for the patient concerning the benefits and risks of therapy is absolutely necessary. An individual therapy concept under consideration of factors, such as the specific clinical relevance and psychological stress is recommended and in close cooperation with the patient.
Full text 10,430 characters · extracted from oa-doi-fallback · 6 sections · click to expand

Material

und Methoden Vergleich aktueller Therapieempfehlungen entsprechend der Leitlinien unter Berücksichtigung einzelner Studien und Grundlagenarbeiten; Auswertung von Arbeiten und deren Interpretation mit dem Hintergrund, eine Hinführung zu dem Thema mit einer Therapieempfehlung zu erstellen. Ergebnisse Die retroperitoneale Endometriose als benigne Erkrankung betrifft aus urologischer Perspektive einen Befall der Harnleiter und der Harnblase. Führt ein Befall der Harnleiter zu einer Hydronephrose, besteht eine absolute Therapieindikation. Auch eine rezidivierende Makrohämaturie bei Befall der Harnblase kann eine Behandlung erforderlich machen. Dieses beinhaltet ist in erster Linie eine operative Entfernung der Endometrioseherde. Verschiedene operative Verfahren und Zugangswege stehen hierfür zur Verfügung, wenn möglich minimal-invasiv. Eine medikamentöse Therapie ist sekundär ebenfalls möglich. Schlussfolgerung Die operative Entfernung eines klinisch relevanten Endometrioseherds ist der Goldstandard in der Therapie. Die Behandlung sollte an spezialisierten Zentren im interdisziplinären Konsens erfolgen. Da es sich um eine primär benigne Erkrankung handelt, ist eine Aufklärung der Patientin über Nutzen und Risiken der Therapie streng erforderlich. Ein individuelles Therapiekonzept unter Berücksichtigung von Faktoren wie dem Leidensdruck und der spezifischen klinischen Relevanz ist in enger Rücksprache mit der Betroffenen zu entwickeln.

Abstract

Background Retroperitoneal endometriosis is a common benign disease, which requires an interdisciplinary approach. In the clinical practice diagnosis is often delayed for years after onset of the unspecific symptoms so that increased awareness is necessary for detection of the presence of the disease.

Objective

This article provides a description of the disease including the symptoms and pathogenesis, an introduction to the complexity of diagnostic investigations and the current therapy recommendations.

Material and methods

Comparison of current therapy recommendations according to the guidelines under consideration of individual studies and background research. Assessment of studies and the accompanying interpretations with the intention of presenting an introduction to the topic with therapy recommendations.

Results

From a urological point of view retroperitoneal endometriosis is a benign disease affecting the ureters and urinary bladder. Involvement of the ureters leading to hydronephrosis caused by ureteral compression represents an absolute indication for therapy. Recurrent macrohematuria can also necessitate treatment. Treatment includes surgical excision of the focal point of endometriosis as the first line therapy. Various operative procedures and access routes are available but when possible a minimally invasive procedure should be used. A second line drug therapy is also possible.

Conclusion

Surgical excision of a clinically significant focus of endometriosis is the gold standard for therapy. This procedure should take place in a specialized center within an interdisciplinary consensus. Due to the fact that endometriosis is primarily a benign disease, medical clarification for the patient concerning the benefits and risks of therapy is absolutely necessary. An individual therapy concept under consideration of factors, such as the specific clinical relevance and psychological stress is recommended and in close cooperation with the patient. Similar content being viewed by others Literatur Bassi MA, Podgaec S, Dias JA Jr (2011) Quality of life after segmental resection of the rectosigmoid by laparoscopy in patients with deep infiltrating endometriosis with bowel involvement. J Minim Invasive Gynecol 18:730–733 Bazot M, Lafont C, Rouzier R et al (2009) Diagnostic accuracy of physical examination, transvaginal sonography, rectal endoscopic sonography, and magnetic resonance imaging to diagnose deep infiltrating endometriosis. Fertil Steril 92:1825–1833 Busacca M, Somigliana E, Bianchi S et al (2001) Post-operative GnRH analogue treatment after conservative surgery for symptomatic endometriosis stage III–IV: a randomized controlled trial. Hum Reprod 16:2399–2402 Chopin N, Vieira M, Borghese B et al (2005) Operative management of deeply infiltrating endometriosis: results on pelvic pain symptoms according to a surgical classification. J Minim Invasive Gynecol 12:106–112 Ebert AD, Ulrich U, Keckstein J et al (2013) Implementation of certified endometriosis centers: 5‑year experience in German-speaking Europe. Gynecol Obstet Invest 76:4–9 Engel J, Berkes E, Tinneberg HR (2015) Klassifikation der Endometriose. Gynakologe 48:200–208 Enzian-Klassifikation. http://www.endometriose-sef.de/dateien/ENZIAN_2013_web.pdf. Zugegriffen: 5.1.2016 Ford J, English J, Miles WA et al (2004) Pain, quality of life and complications following the radical resection of rectovaginal endometriosis. Br J Obstet Gynaecol 111:353–356 Furness S, Roberts H, Marjoribanks J et al (2012) Hormone therapy in postmenopausal women and risk of endometrial hyperplasia. Cochrane Database Syst Rev 8:CD000402 Garry R (2004) The effectiveness of laparoscopic excision of endometriosis. Curr Opin Obstet Gynecol 16:299–303 Ghezzi F, Cromi A, Bergamini V et al (2006) Outcome of laparoscopic ureterolysis for ureteral endometriosis. Fertil Steril 86:418–422 Halis G, Mechsner S, Ebert AD (2010) The diagnosis and treatment of deep infiltrating endometriosis. Dtsch Arztebl Int 107:446–455 (quiz 456) Hudelist G, Fritzer N, Thomas A et al (2012) Diagnostic delay for endometriosis in Austria and Germany: causes and possible consequences. Hum Reprod 27:3412–3416 Kaufmann M, Costa S‑D, Scharl A (2013) Die Gynäkologie, 3. Aufl. Springer, Heidelberg Kruger K, Gilly L, Niedobitek-Kreuter G et al (2014) Bladder endometriosis: characterization by magnetic resonance imaging and the value of documenting ureteral involvement. Eur J Obstet Gynecol Reprod Biol 176:39–43 Leitlinie Diagnostik Und Therapie Endometriose. http://www.awmf.org/uploads/tx_szleitlinien/015-045l_S2k_Diagnostik_Therapie_Endometriose_2013-10.pdf. Zugegriffen: 5.1.2016 Melin A, Sparen P, Bergqvist A (2007) The risk of cancer and the role of parity among women with endometriosis. Hum Reprod 22:3021–3026 Mereu L, Gagliardi ML, Clarizia R et al (2010) Laparoscopic management of ureteral endometriosis in case of moderate-severe hydroureteronephrosis. Fertil Steril 93:46–51 Meuleman C, Tomassetti C, D’hooghe TM (2012) Clinical outcome after laparoscopic radical excision of endometriosis and laparoscopic segmental bowel resection. Curr Opin Obstet Gynecol 24:245–252 Meyer R (1919) Über den Stand der Frage der Adenomyositis, Adenomyome im allgemeinen und insbesondere über Adenomyositis seroepithelialis und Adenomyometritis sarcomatosa. Zentralbl Gynakol 36:745–750 Nezhat C, Hajhosseini B, King LP (2011) Laparoscopic management of bowel endometriosis: predictors of severe disease and recurrence. J Soc Laparoendosc Surg 15:431–438 Nezhat C, Hajhosseini B, King LP (2011) Robotic-assisted laparoscopic treatment of bowel, bladder, and ureteral endometriosis. J Soc Laparoendosc Surg 15:387–392 Pearce CL, Templeman C, Rossing MA et al (2012) Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies. Lancet Oncol 13:385–394 Perez-Utrilla PM, Aguilera BA, Dorrego AJM et al (2009) Urinary tract endometriosis: clinical, diagnostic, and therapeutic aspects. Urology 73:47–51 Possover M, Diebolder H, Plaul K et al (2000) Laparascopically assisted vaginal resection of rectovaginal endometriosis. Obstet Gynecol 96:304–307 Rozsnyai F, Roman H, Resch B et al (2011) Outcomes of surgical management of deep infiltrating endometriosis of the ureter and urinary bladder. J Soc Laparoendosc Surg 15:439–447 Sampson J (1940) The development of the implantation theory for the origin of peritoneal endometriosis. Am J Obstet Gynecol 40:549–557 Sampson J (1927) Peritoneal endometriosis due to menstrual dissemination of the endometrial tissue into the peritoneal cavity. Am J Obstet Gynecol 14(4):422–469 Sampson JA (1927) Metastatic or embolic endometriosis, due to the menstrual dissemination of endometrial tissue into the venous circulation. Am J Pathol 3:93–110 (s143) Soriano D, Schonman R, Nadu A et al (2011) Multidisciplinary team approach to management of severe endometriosis affecting the ureter: long-term outcome data and treatment algorithm. J Minim Invasive Gynecol 18:483–488 Stillwell TJ, Kramer SA, Lee RA (1986) Endometriosis of ureter. Urology 28:81–85 Swiersz LM (2002) Role of endometriosis in cancer and tumor development. Ann N Y Acad Sci 955:281–292 (discussion 293–285, 396–406) Tuttlies FKJ, Ulrich U, Possover M, Schweppe K, Wustlich M, Buchweitz O, Greb R, Kandolf O, Mangold R, Masetti W, Neis K, Rauter G, Reeka N, Richter O, Schindler A, Sillem M, Terruhn V, Tinneberg H (2005) ENZIAN-score, a classification of deep infiltrating endometriosis. Zentralbl Gynakol 127:275–281 Ulrich U, Keckstein J (2005) Diagnosing endometriosis. Zentralbl Gynakol 127:295–298 Vessey MP, Villard-Mackintosh L, Painter R (1993) Epidemiology of endometriosis in women attending family planning clinics. BMJ 306:182–184 Author information Authors and Affiliations Corresponding author Ethics declarations Interessenkonflikt R.H. Waegner, M. Schmid, L. Trojan und S.A. Ahyai geben an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren. Rights and permissions About this article Cite this article Waegner, R.H., Schmid, M., Trojan, L. et al. Retroperitoneale Endometriose. Urologe 55, 756–762 (2016). https://doi.org/10.1007/s00120-016-0119-0 Published: Issue date: DOI: https://doi.org/10.1007/s00120-016-0119-0 Schlüsselwörter - Endometriose, retroperitoneal - Endometriose, periureteral - ENZIAN-Klassifikation - Hydronephrose - Makrohämaturie

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosis

MeSH descriptors

Endometriosis Retroperitoneal Space Urologic Diseases Urologic Diseases Diagnosis, Differential Endometriosis Endometriosis Endometriosis Evidence-Based Medicine Female Humans Retroperitoneal Space Treatment Outcome Urologic Diseases Urologic Diseases

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (31)

Source provenance

europepmc
last seen: 2026-08-06T06:07:45.168820+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:21:00.404924+00:00
unpaywall
last seen: 2026-06-13T06:42:57.164913+00:00
License: CC0 · commercial use OK