PTBP3 promotes tumorigenesis of glioblastoma by stabilizing Twist1

Glioblastoma (GBM) is the most common malignancy tumor of central nervous system. PTBP3 was closely associated with the development of tumor. However, the function and mechanism of PTBP3 in GBM is little known. We found that PTBP3 was upregulated in GBM, and higher expression of PTBP3 corrected with the poor survival of GBM patients. Knockdown PTBP3 reduced proliferation, EMT, invasion, and migration of GBM. Conversely, overexpressing PTBP3 has an opposite effect. Moreover, we found that PTBP3 stabilized Twist1 by decreasing its ubiquitination and degradation. Furthermore, orthotopic xenograft models were used to demonstrate the PTBP3 on the development of GBM in vivo . This study proved that PTBP3 promoted tumorigenesis of GBM by stabilizing Twist1, which provided a new therapeutic target for GBM.