RARE CASE OF PRIMARY AML WITH TP53 DELETION

P53-mutated AML is typically therapy-related and rarely seen as primary disease, especially in children. We report a case of pediatric AML with P53 deletion. A 5-year-old male presented with fever for 2-week duration. Peripheral smear showed 6% atypical cells, and bone marrow aspirate revealed 30% blasts. Flow cytometry confirmed AML. Following induction therapy with cytarabine and daunomycin; the disease was persistent. On re-evaluation, the Karyotype showed loss of chromosome 17, and FISH confirmed P53 deletion. This case highlights the need to consider P53 mutation in refractory pediatric AML. Targeted therapies may improve outcomes.