The origin of life: the first self-replicating molecules were nucleotides

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Abstract

Difficulties to synthesize RNA nucleotides from their subunits in modern labs under simulated environments leads us to propose a possible process for the synthesis by cross complimentary self-replication with help of clay minerals, which might be operated on prebiotic Earth. Clay minerals are known to be good catalysts and certainly existed on prebiotic Earth. The self-replication of RNA nucleotides (monomers) may be considered as the origin of potential self-replication of some extant RNA polymers, and also the reason for homochirality of RNA molecules.

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europepmc
last seen: 2026-05-19T01:45:01.086888+00:00
unpaywall
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License: CC-BY-4.0