Evaluation of dyslipidemia based on ATP ⅠⅠⅠ guideline in adults in southwest Iran: A population-based study

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This population-based cross-sectional study assessed the prevalence and correlates of dyslipidemia in 9,846 adults aged 35–70 years from southwest Iran, using ATP III guideline criteria and collecting socioeconomic factors, comorbidities, laboratory values, anthropometrics, and lifestyle data. Dyslipidemia prevalence was 43.5%, with abnormal HDL (17.9%), LDL (21.8%), total cholesterol (36.2%), and triglycerides (44%), and multiple logistic regression identified higher odds among males, individuals with abnormal waist circumference, smokers, “rich” participants, and those with hypertension, while low physical activity was also associated (as reported in the abstract). A key limitation explicitly stated in the provided text is that this is a preprint and thus not peer reviewed. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Abstract Dyslipidemia is a primary risk factor for cardiovascular disease. We aim to investigate the occurrence of dyslipidemia and its associated risk factors in the southwest region of Iran. This population-based cross-sectional study was conducted on 9846 participants aged 35–70 years in southwest Iran. Information on socioeconomic factors, demographic characteristics, comorbidities, laboratory tests, anthropometric measurements, and lifestyle was collected. The criteria for dyslipidemia were based on the ATP III classification. Multiple logistic regression was used to control potential confounders. Results showed that the overall prevalence of dyslipidemia was 43.5%, with abnormal levels of HDL, LDL, TC, and TG at 17.9%, 21.8%, 36.2%, and 44%, respectively. The multiple logistic regression analysis revealed that males (OR=1.92, 95%CI: 1.74−2.14), individuals with abnormal waist circumference (OR=1.88, 95% CI: 1.67-2.12), those with low physical activity (OR=0.80, 95% CI: 0.76-0.97), smokers (OR=1.17, 95%CI: 1.05−1.31), rich people (OR=1.19, 95%CI: 1.04-1.36), and patients with hypertension (OR=1.16, 95% CI: 1.05-1.27) had higher odds of dyslipidemia. Our findings suggest that dyslipidemia is a complex condition that is influenced by various biological and lifestyle factors. Different prevention and treatment strategies may be needed for various population subgroups. Keywords: Dyslipidemia, ATP III guidelines, Adults, Population-based study.
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Evaluation of dyslipidemia based on ATP ⅠⅠⅠ guideline in adults in southwest Iran: A population-based study | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Evaluation of dyslipidemia based on ATP ⅠⅠⅠ guideline in adults in southwest Iran: A population-based study Bahman Cheraghian, Nader Saki, Sara Sarvandian, Seyed Jalal Hashemi, and 3 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4302184/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 19 Mar, 2025 Read the published version in Scientific Reports → Version 1 posted 14 You are reading this latest preprint version Abstract Dyslipidemia is a primary risk factor for cardiovascular disease. We aim to investigate the occurrence of dyslipidemia and its associated risk factors in the southwest region of Iran. This population-based cross-sectional study was conducted on 9846 participants aged 35–70 years in southwest Iran. Information on socioeconomic factors, demographic characteristics, comorbidities, laboratory tests, anthropometric measurements, and lifestyle was collected. The criteria for dyslipidemia were based on the ATP III classification. Multiple logistic regression was used to control potential confounders. Results showed that the overall prevalence of dyslipidemia was 43.5%, with abnormal levels of HDL, LDL, TC, and TG at 17.9%, 21.8%, 36.2%, and 44%, respectively. The multiple logistic regression analysis revealed that males (OR=1.92, 95%CI: 1.74−2.14), individuals with abnormal waist circumference (OR=1.88, 95% CI: 1.67-2.12), those with low physical activity (OR=0.80, 95% CI: 0.76-0.97), smokers (OR=1.17, 95%CI: 1.05−1.31), rich people (OR=1.19, 95%CI: 1.04-1.36), and patients with hypertension (OR=1.16, 95% CI: 1.05-1.27) had higher odds of dyslipidemia. Our findings suggest that dyslipidemia is a complex condition that is influenced by various biological and lifestyle factors. Different prevention and treatment strategies may be needed for various population subgroups. Keywords: Dyslipidemia, ATP III guidelines, Adults, Population-based study. Biological sciences/Biochemistry Biological sciences/Chemical biology Health sciences/Diseases Health sciences/Medical research Health sciences/Risk factors Dyslipidemia ATP III guidelines Adults Population-based study Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Published Journal Publication published 19 Mar, 2025 Read the published version in Scientific Reports → Version 1 posted Editorial decision: Revision requested 14 Oct, 2024 Reviews received at journal 12 Oct, 2024 Reviewers agreed at journal 30 Sep, 2024 Reviews received at journal 28 Sep, 2024 Reviewers agreed at journal 26 Sep, 2024 Reviews received at journal 14 Sep, 2024 Reviewers agreed at journal 14 Sep, 2024 Reviewers agreed at journal 14 Sep, 2024 Reviewers agreed at journal 14 Sep, 2024 Reviewers invited by journal 25 Jun, 2024 Editor assigned by journal 25 Jun, 2024 Editor invited by journal 06 Jun, 2024 Submission checks completed at journal 06 Jun, 2024 First submitted to journal 21 Apr, 2024 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. 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