Expression of cyclin E and p27 protein in endometriosis
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Immunohistochemistry revealed that cyclin E expression is significantly higher and p27 expression is lower in endometriosis than normal tissue, with their inverse correlation linked to disease stage.
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Abstract
Objective To study the expression of Cyclin E and p27 protein in endometriosis.Methods The levels of cyclin E and p27 protein were detected with immunohistochemisty.Results The expression of cyclin E in endometriosis was significantly higher than that in normal tissues(P0.001),whereas The expression of p27 in endometriosis was significantly lower than that in normal tissues(P0.001).There was negative correlation between p27 and cyclin E in endometriosis(P0.05).The expression of p27 and cyclin E were significantly correlated with clinical stages(P0.05).Conclusions As cell cycle regulatory factors,cyclin E and p27 protein might be involved in development of endometriosis.
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- openalex
- last seen: 2026-06-04T00:00:01.174412+00:00
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