Isolated Vaginal Bleeding Before the Onset of Puberty

Natalie G. Allen, Paul B. Kaplowitz
In: Endocrinology and Metabolism Clinics of North America · 2024 · vol. 53(2) , pp. 211–216 · doi:10.1016/j.ecl.2024.01.003 · PMID:38677864 · W4392094263
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Abstract

Isolated vaginal bleeding before the onset of puberty is a rare presentation of isosexual precocity. In most cases, isolated vaginal bleeding without an abnormal genital examination is self-limited with resolution usually within 1 to 3 episodes. Watchful waiting is appropriate in most patients who do not have persistent bleeding, other signs of puberty, or signs/symptoms of an underlying etiology. Workup for patients with concerning features may include puberty hormone levels and/or transabdominal and transperineal ultrasound.

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