Effects of different intensity endurance training on atrial fibrillation in Rats

Effects of different intensity endurance training on atrial fibrillation in Rats | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Effects of different intensity endurance training on atrial fibrillation in Rats Jingwen Xiao, Jiancheng Zhang, Yan Zhang, Chuanchuan Li, Chenqi Yang, and 3 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-3186844/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background Exercise has a positive effect on various cardiovascular diseases. However, it is not uncommon to experience arrhythmia events during or after exercising. Objective To determine how to maximize the benefits of exercise while ensuring safety. Methods we conducted a study involving 40 adult Sprague-Dawley rats. These rats underwent exercise of different intensities for 8 weeks. We recorded electrophysiological stimulation to track the occurrence and duration of atrial fibrillation, along with other electrophysiological data. Additionally, we analyzed and observed the histology of cardiomyocytes. Results The results revealed a relationship between exercise intensity and the incidence of atrial fibrillation and myocardial lipid deposition. As exercise intensity increased, there were an increase in myocardial fibrosis, mitochondrial activity, and autophagy and a decrease in reactive oxygen species. The expression of NCX1 and Kv1.5 proteins in rat atrial cardiomyocytes exhibited varying degrees of change. The increase in myocardial lipid level after exercise is thought to have a significant effect on myocardial fibrosis, which may be related to the upregulation of peroxisome proliferator-activated receptor-gamma coactivator 1 alpha expression. Conclusion Sustained and moderate-intensity exercise is considered more suitable for improving myocardial metabolic energy supply and treating atrial arrhythmias. Biological sciences/Physiology Health sciences/Biomarkers Health sciences/Cardiology Health sciences/Medical research endurance training atrial fibrillation PGC-1α myocardial lipid deposition myocardial fibrosis Full Text Additional Declarations No competing interests reported. Supplementary Files SupplementaryInformation.pdf Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-3186844","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":274496748,"identity":"9b5c5fa0-bb58-445d-9ddc-db46c70a2004","order_by":0,"name":"Jingwen Xiao","email":"","orcid":"","institution":"Shengli Clinical College affiliated of Fujian Medical University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Jingwen","middleName":"","lastName":"Xiao","suffix":""},{"id":274496749,"identity":"bc3203a4-5250-4eb4-9e4e-8d3438bf6f2b","order_by":1,"name":"Jiancheng 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fibrosis","lastPublishedDoi":"10.21203/rs.3.rs-3186844/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-3186844/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003ch2\u003eBackground\u003c/h2\u003e \u003cp\u003eExercise has a positive effect on various cardiovascular diseases. However, it is not uncommon to experience arrhythmia events during or after exercising.\u003c/p\u003e\u003ch2\u003eObjective\u003c/h2\u003e \u003cp\u003eTo determine how to maximize the benefits of exercise while ensuring safety.\u003c/p\u003e\u003ch2\u003eMethods\u003c/h2\u003e \u003cp\u003ewe conducted a study involving 40 adult Sprague-Dawley rats. These rats underwent exercise of different intensities for 8 weeks. We recorded electrophysiological stimulation to track the occurrence and duration of atrial fibrillation, along with other electrophysiological data. Additionally, we analyzed and observed the histology of cardiomyocytes.\u003c/p\u003e\u003ch2\u003eResults\u003c/h2\u003e \u003cp\u003eThe results revealed a relationship between exercise intensity and the incidence of atrial fibrillation and myocardial lipid deposition. As exercise intensity increased, there were an increase in myocardial fibrosis, mitochondrial activity, and autophagy and a decrease in reactive oxygen species. The expression of NCX1 and Kv1.5 proteins in rat atrial cardiomyocytes exhibited varying degrees of change. The increase in myocardial lipid level after exercise is thought to have a significant effect on myocardial fibrosis, which may be related to the upregulation of peroxisome proliferator-activated receptor-gamma coactivator 1 alpha expression.\u003c/p\u003e\u003ch2\u003eConclusion\u003c/h2\u003e \u003cp\u003eSustained and moderate-intensity exercise is considered more suitable for improving myocardial metabolic energy supply and treating atrial arrhythmias.\u003c/p\u003e","manuscriptTitle":"Effects of different intensity endurance training on atrial fibrillation in Rats","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-02-26 17:05:10","doi":"10.21203/rs.3.rs-3186844/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"53aadb92-af54-4557-8c71-44eb34752ebd","owner":[],"postedDate":"February 26th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":28936380,"name":"Biological sciences/Physiology"},{"id":28936381,"name":"Health sciences/Biomarkers"},{"id":28936382,"name":"Health sciences/Cardiology"},{"id":28936383,"name":"Health sciences/Medical research"}],"tags":[],"updatedAt":"2024-05-07T18:20:16+00:00","versionOfRecord":[],"versionCreatedAt":"2024-02-26 17:05:10","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-3186844","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-3186844","identity":"rs-3186844","version":["v1"]},"buildId":"cBFmMYwuxLRRLfASyISRj","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}