Design, synthesis, and antifungal activity of 14-aryloxy/amide substituted andrographolide derivatives

Design, synthesis, and antifungal activity of 14-aryloxy/amide substituted andrographolide derivatives | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Design, synthesis, and antifungal activity of 14-aryloxy/amide substituted andrographolide derivatives Zhuyun Liu, Shanshan Yang, Jieru Ma, Yunying Sha, Yuyan Zhou, and 2 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7031196/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 25 Nov, 2025 Read the published version in Scientific Reports → Version 1 posted 11 You are reading this latest preprint version Abstract In order to find more compounds with antifungal activities, a series of new compounds were designed and synthesized using the natural product of diterpenoid lactones, andrographolide, as the parent nucleus. Target compounds were identified by 1 H NMR, 13 C NMR and/or HR-MS. The results of antifungal activity showed that the antifungal activities of 4d against 6 tested fungi were all more than 60% at 100 μg/mL, and the inhibitory activity of 4d against the 6 tested fungi than the positive control Kresoxim-methyl. SEM test showed that 4d could damage the mycelia of P. piricola. obviously. Moreover, 4d had no effect on cowpea seed germination, showing high safety. Biological sciences/Biochemistry Biological sciences/Biotechnology Biological sciences/Drug discovery Biological sciences/Microbiology Biological sciences/Plant sciences Full Text Additional Declarations No competing interests reported. Supplementary Files Supportinginformation.pdf Cite Share Download PDF Status: Published Journal Publication published 25 Nov, 2025 Read the published version in Scientific Reports → Version 1 posted Editorial decision: Revision requested 30 Sep, 2025 Reviews received at journal 21 Sep, 2025 Reviewers agreed at journal 12 Sep, 2025 Reviews received at journal 11 Sep, 2025 Reviewers agreed at journal 07 Sep, 2025 Reviewers agreed at journal 22 Aug, 2025 Reviewers invited by journal 21 Aug, 2025 Editor assigned by journal 21 Aug, 2025 Editor invited by journal 06 Aug, 2025 Submission checks completed at journal 09 Jul, 2025 First submitted to journal 09 Jul, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7031196","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":506068101,"identity":"299ee581-1ec9-41d4-bd31-300f95f75760","order_by":0,"name":"Zhuyun 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