218 The Efficacy of Vaginal Moisturizers Composed of β-glucans in Treatment of Vulvo-vaginal Atrophy with Post-menopausal Women

Vaginal dryness is common symptom of vulvo-vaginal atrophy (VVA) that is particularly prevalent with post-menopausal women. While estrogen replacement is effective, it is not suitable or accepted for all women, and a non-hormonal treatment is often needed instead. We focused natural β-glucans which possess anti-infection, immune-modulating and moisturizing properties. To investigate the efficacy and safety of vaginal moisturizers which composed with natural β-glucans on VVA related vaginal dryness. The prospective crossover study was conducted. Twenty patients were randomized to 1 of 2 treatment sequences, application vaginal moisturizers type 1 (composed of 0.6 % β-glucan only)-type 2 (composed of 0.6% β-glucan and 0.6% hyaluronic acid) or type 1–type 3 (composed of 0.6% β-glucan and extracts from Sophora flavescens, Houttuynia Cordata Extract, Aloe barbadensis). Each types of vaginal moisturizers was given for 5 days, separated by a 1-week washout interval. Efficacy was assessed by the vaginal pH, vaginal swab culture and patient self-reporting of improvement of VVA related symptoms questionnaire.