The endometrium: is thickness all that counts?

Paul Pirtea, Baris Ata, Barış Ata
Reproductive BioMedicine Online · 2025 · vol. 52(3) , pp. 105277 · doi:10.1016/j.rbmo.2025.105277 · PMID:41576758 · W4414572775
Review OA: bronze CC0
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-09 ⓘ

This paper examines the significance of endometrial thickness in reproductive outcomes and reviews current understanding of the endometrium's complex role beyond just its measurement.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

The commonly used 7 mm threshold for endometrial thickness in assisted reproductive technology lacks strong evidence and stems from outdated data. Recent studies show that live birth outcomes are comparable even with linings of less than 7 mm, particularly when using euploid embryos. Measurement variability, confounding factors and differing clinical practices limit the reliability of endometrial thickness as a standalone predictor. While extremely thin linings may warrant further evaluation, rigid cut-off values are unjustified. Endometrial thickness should be integrated into a broader, individualized assessment rather than drive clinical decisions in isolation.

My notes (saved in your browser only)

MeSH descriptors

Endometrium Endometrium Endometrium Reproductive Techniques, Assisted Embryo Transfer Female Humans Pregnancy Ultrasonography

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. This is a recent paper (2025) — citers typically take a year or two to land, and the OpenAlex reference graph may still be filling in.

References (6)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:53:33.133376+00:00
License: CC0 · commercial use OK