Nifedipine Modulated Renal Lipogenesis via AMPK-SREBP Transcriptional Pathways

The hypothesis being tested Lipid accumulation in renal cells has been implicated in the pathogenesis of obesity-related kidney disease, and lipotoxicity occurring in kidney can be considered to be a surrogate marker for renal failure or renal fibrosis. Nifedipine-induced lipotoxicity in kidney has never been cited, although a few literature had shown that Nifedipine inhibited lipogenesis via activation of the LKB1-AMPK pathway. Previously, we had recognized in our laboratory some events that seemingly were associated with lipogenesis affected by administration of Nifedipine.