Global Changes in Gene Expression and Splicing in Alcoholic Liver Disease

Global Changes in Gene Expression and Splicing in Alcoholic Liver Disease | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Global Changes in Gene Expression and Splicing in Alcoholic Liver Disease Ilya O. Blokhin, Derek Van Booven, Josepmaria Argemi, Mengying Li, and 7 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7380649/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted 13 You are reading this latest preprint version Abstract Alcohol use disorder is a widespread illness commonly leading to alcoholic liver disease (ALD) and cirrhosis with an increased incidence of hepatocellular carcinoma (HCC), but the mechanisms of alcohol-related oncogenesis in the liver are incompletely understood. We tested the hypothesis that ALD predisposes to HCC via dysregulation of splicing. RNA sequencing was performed on liver biopsies from patients with different stages of ALD: early alcoholic steatohepatitis (eASH), non-severe alcoholic hepatitis (nsAH), and severe alcoholic hepatitis (sAH); furthermore, explants were collected from patients who underwent liver transplantation due to sAH (exAH). We found that alcohol caused widespread changes in transcriptome in all stages of ALD: among ~ 58,000 analyzed genomic features, ~ 4,900 were altered in eASH, ~ 9,100 – in nsAH, 14,100 – in sAH, and ~ 14,300 – in exAH. We observed thousands of missplicing events in all hepatic conditions, with mutually exclusive exons (MEE) being the most common event and exon skipping (ES) – second most common event. Analysis of ~ 600,000 exons revealed that ALD is associated with a genome-wide effect on exon expression, with ~ 50,000 exons being differentially expressed in eASH, ~ 130,000 – in nsAH, ~ 150,000 – in sAH, and ~ 120,000 – in exAH. To determine whether alcohol directly perturbs splicing, we subjected rats to alcohol vapor for 7 weeks and found that the expression of multiple snRNAs was drastically decreased, while expression of splicing factors was not affected. Screening of oncogenes and tumor suppressors, commonly involved in HCC pathogenesis, revealed that ALD affected the hepatic expression and/or splicing of most of these cancer-related genes. In summary, it appears that alcohol causes profound genome-wide changes in gene expression and splicing in the liver, likely via affecting the spliceosome. This results in altered expression and missplicing of key oncogenes and tumor suppressors involved in HCC, suggesting a novel mechanism of oncogenesis in the liver of patients with ALD. Biological sciences/Cancer Health sciences/Diseases Health sciences/Gastroenterology Biological sciences/Genetics Biological sciences/Molecular biology alcohol use disorder alcoholic liver disease splicing spliceosome long non-coding RNA hepatocellular carcinoma Figures Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Introduction Alcohol use disorder (AUD) is a chronic condition characterized by a problematic pattern of alcohol use leading to clinically significant impairment. According to the World Health Organization, alcohol consumption accounts for 4.7% of all deaths worldwide 1 . In the United States, 14% of adults currently meet criteria of AUD, 29% – met AUD criteria once during their lifetime 2 ; in addition, prevalence of AUD is increasing 3 – 5 . Annual cost of AUD and alcohol-related disorders is ~ $ 250 billion 6 , 7 . Due to high prevalence and lack of efficient treatment modalities, AUD causes significant socioeconomic burden. Apart from direct physiological and psychological problems associated with AUD, the burden is connected to alcohol-related medical conditions. One of the major and most common co-morbidities is alcoholic liver disease (ALD) which, in turn, is associated with hepatocellular carcinoma (HCC). ALD is a broad diagnosis which encompasses the continuum of alcoholic steatosis, alcoholic steatohepatitis (eASH), alcoholic hepatitis (AH), and, finally, cirrhosis 8 . Most patients develop HCC at the stage of cirrhosis, but 11–31% of HCC patients present with HCC in the absence of cirrhotic changes 9 , 10 . HCC is the most common liver cancer and one of the most aggressive cancers. Worldwide, ~ 850,000 people are diagnosed with HCC every year 11 , 12 . Therapeutic approaches for advanced stage HCC are very few. Modest improvement was observed after administration of multiple tyrosine kinase inhibitors sorafenib and lenvatinib 13 , 14 and immunotherapies 15 , 16 , but prognosis for patients with advanced HCC is still poor, with an overall survival of around 1 year with the best treatment implemented 17 . HCC remains the second leading cause of cancer-related death in the world claiming ~ 700,000 deaths annually 18 , 19 . The link between AUD and HCC is well established in case-control studies 20 and meta-analyses 21 , and alcohol-related HCC was shown to have significantly worse prognosis than HCC related to viral hepatitides 22 , 23 . That treatment of HCC is often insufficient may result from an incomplete insight on how HCC arises and progresses. HCC represents a heterogeneous group of tumors with molecular signatures closely connected to risk factors 24 . It is possible that AUD-related HCC develops via distinct molecular mechanism 25 and that some alcohol-induced molecular changes causing or predisposing to HCC occur at the stage of AH 9 , 10 . Recent data indicate that potential mechanistic overlap between AUD and HCC may involve impaired splicing. Splicing is a nuclear process of removing introns from pre-mRNA after which mature mRNA is produced and exported into the cytoplasm for translation. Splicing is mediated by a major spliceosome, a nuclear machinery which consists of 5 small nuclear RNAs (snRNA1 (snU1), snU2, snU4, snU5, and snU6) and dozens of splicing factors 26 . Among snRNAs, snU1 and snU2 are considered to be critical. snU1 recognizes 5’ splice site forming the early splicing complex while snU2 recognizes 3’ splice site. Among chief splicing factors with an established link to cancers are SF1, SF3B1, SRSF1, SRSF2, SRSF3, ZRSR2, and U2AF1 27–29 . SF1 is responsible for the recognition of the branch point 30 . When branch point pairs with snU2, SF1 is displaced and branching site is contacted by SF3B1, a core component of the U2 small nuclear ribonucleoprotein (U2 snRNP), which ensures stabilization of U2 snRNP on pre-mRNA 26 . SRSF1, SRSF2, and SRSF3 belong to the family of serine-arginine (SR) splicing factors which contain a protein domain composed of SR repeats; SRSF proteins are recruited with snU1 by RNA polymerase II and function mainly to couple splicing with transcription 31 . ZRSR2 and U2AF1 are required for the recognition of 3’ splice site 32 , 33 . Regulation of splicing is poorly understood, but there is some evidence indicating that long non-coding RNAs (lncRNAs) might be involved. LncRNAs are non-coding RNA molecules > 200 nucleotides in length which are capable of interacting with both short RNAs and proteins 34 and thus may serve as a “screwdriver” for spliceosome. It was shown that lncRNA Gomafu (also known as myocardial infarction-associated transcript (MIAT)) affects formation of spliceosomes and inhibits splicing factor SF1 35 . Another lncRNA, MALAT1, interacts with SR splicing factors causing deregulation of splicing in a genome-wide fashion 36 , 37 . Data on splicing in AUD are relatively scanty. Alcohol intake was shown to be associated with a missplicing of specific transcripts such as mRNA for AMPA receptors 38 and GABA-B receptors 39 . Disruption of splicing on a broader scale was observed in the brain cortex of human fetuses exposed to alcohol 40 . In our previous work, we observed AUD-induced genome-wide missplicing in different brain regions 41 . In HCC, splicing is studied more extensively. Analysis of HCC transcriptome identified > 2,000 genes with altered splicing patterns which were distinct in HBV-induced, HCV-induced, and non-viral HCC 42 . It was also shown that HCC was accompanied by 34,163 alternative splicing events in 8,985 genes, and some missplicing patterns were associated with overall survival 43 . However, the extent and mechanisms of missplicing in AUD and ALD-related HCC remain unknown. The goal of the current study was to determine if AUD may relate to HCC via missplicing in the liver. We found that chronic alcohol use causes genome-wide changes in hepatic gene expression and splicing. Mechanistically, it appears to be mediated by defects in the spliceosomal machinery as well as by an aberrant expression of lncRNAs related to splicing. Numerous oncogenes and tumor suppressors were among affected genes in all alcohol-related hepatic conditions suggesting a novel mechanism contributing to the development of AUD-related HCC. Results Subjects Demographics and pertinent clinical data are listed in Table 1. Patients with alcohol-induced liver damage did not differ in age or gender. Child-Pugh, MELD, and ABIC scores all increased from nsAH to sAH, but there was no difference between sAH and exAH groups. Frequency of symptoms of hepatic decompensation such as ascites, hepatic encephalopathy, upper gastrointestinal bleeding, acute kidney injury, and infections tended to increase from nsAH to sAH. White blood cell counts increased and hemoglobin and platelet counts decreased throughout eASH-nsAH-sAH-exAH continuum. As expected, levels of bilirubin alkaline phosphatase were higher in patients with alcohol-induced liver damage. Liver diseases were also associated with low albumin, hyponatremia, and increased prothrombin time (expressed as International Normalized Ratio (INR)). Of note, creatinine levels were normal across phenotypes, ruling out the presence of hepatorenal syndrome. Effect of alcohol on hepatic transcriptome We have previously shown that there are extensive transcriptomic changes imparted by some stages of ALD 44 , but the assessment of ALD-related transcriptomic reprogramming encompassed only protein-coding genes and did not include the analysis of splice variants. We therefore decided to interrogate RNA sequences datasets in order to evaluate the extent of differential expression and missplicing of both coding and non-coding features. The analysis of expression of 57,820 features confirmed that alcohol caused genome-wide changes in hepatic transcriptome, with a number of differentially expressed genes positively correlating with a disease severity. In eASH, 4,928 were altered (8.5%), in nsAH – 9,075 (15.7%), in sAH – 14,100 (24.4%), and in exAH – 14,292 (24.7%) (Fig. 1 ). When considering the RNA biotypes, the composition of altered transcriptomes was relatively similar in all alcohol-related condition, with a majority of affected genes (60–70%) being represented by protein-coding genes (Supplementary Fig. S1 ). Altered transcriptome profiles demonstrated a considerable overlap (data not shown) suggesting that alcohol-related transcriptomic changes are persistent, cumulative along the progression of ALD, and unlikely to be random. To address functional implications of altered transcriptomes, we analyzed transcriptomic overlaps between eASH and later stages of alcohol-induced hepatic damage such as sAH and exAH. Gene Ontology analysis of overlapping suppressed genes revealed that downregulated features are mainly involved in oncogenesis: affected pathways included DNA replication, DNA damage response, cell cycle, and regulation of mitosis (Supplementary Tables 1 and 2). Next, we asked if there are transcriptional changes that persist across all stages of alcohol-induced hepatic damage and assessed determined genes up- or downregulated in all four groups. In total, expression of 1,265 were either increased or decreased throughout eASH-nsAH-sAH-exAH continuum (Fig. 2 ). 440 genes were upregulated in all groups, 825 – downregulated in all groups (Supplementary Table 3) indicating the broad character of alcohol-induced transcriptomic changes across all conditions. Effect of alcohol on splicing Effect of alcohol on splicing in the liver has not been well studied, and extent and characteristics of hepatic missplicing in ALD are not known. We employed MATS program 45 to unbiasedly detect such missplicing events as 5’ alternative splice sites (5’-SS), 3’ alternative splice sites (3’-SS), intron retention (IR), exon skipping (ES) and mutually exclusive exons (MEE). In all alcohol-related conditions, ES and MEE were the most common events (Fig. 3 ). Number of ES was relatively similar across all conditions: 1,542, 1,668, 1660, and 1,623 in eASH, nsAH, sAH, and exAH, respectively. MEE, on the other hand, differed significantly in various conditions. The number of MEEs was 1,186 in eASH, rose to 3,119 in nsAH, and then subsided to 2,668 and 2,094 in sAH and exAH, respectively. Frequency of 5’-SS, 3’-SS, and IR was much lower in comparison to ES and MEE, and the dynamics of their quantitative changes was similar, being observed at the stage of eASH, occurring most frequently at the stage of nsAH, and returning to eASH levels at sAH and exAH stages. Effect of alcohol on exon expression Based on the high number of alcohol-induced missplicing events across all conditions, we hypothesized that the variety of differentially expressed transcripts in the liver may be larger than detected on standard differential expression analysis (Fig. 1 ). We reasoned that missplicing may cause changes in the expression and presence of specific exons without altering a total expression counts of a specific gene, as quantified by conventional pipelines. In such a case, the quantification of individual exons might therefore provide a more accurate insight into alcohol-induced changes in transcriptional landscape and give clues of potentially relevant changes in mRNA and amino acid sequence of key molecular drivers. We used DEXSeq R package to perform exon expression analysis. The interrogation of 588,998 exons showed that alcohol causes genome-wide changes in exon expression, with number of affected exons positively correlating with the stage of disease. Thus, 46,045 (7.8%) exons were altered in eASH, 126,145 (21.4%) – in nsAH, 152,335 (25.9%) – in sAH, and 123,282 (20.9%) – in exAH (Fig. 4 ). Effect of alcohol on snRNAs We next asked which mechanism may be responsible for such broad alcohol-induced alterations of splicing landscape. Splicing is governed mainly by a major spliceosome, a nuclear machinery which consists of 5 small nuclear RNAs (snRNA) and multiple proteins, known as splicing factors. The snRNAs are involved in the recognition of introns, formation of splicing complexes, and splicing reactions 46 , 47 . The major spliceosome includes 5 snRNAs: snU1, snU2, snU4, snU5, and snU6. Although data on AUD-induced changes in splicing began to accumulate 40 , 41 , 48 , the impact of alcohol on snRNA has not been explored. In most publicly available RNA sequencing datasets in alcohol-related disease studies, snRNAs are not well represented. Only in one of them 49 did we find robust expression values for most snRNAs; this study showed that treatment of primary hepatocytes with alcohol resulted in decreased expression of snU1 and snU4. That snRNAomes from most public RNA sequencing sources (such as NCBI or TCGA) are missing or unreliable may be due to the length of snRNAs: mature snRNAs are relatively short (< 200 nucleotides) and may not be detected by standard RNA sequencing protocols. Therefore, to investigate the direct effect of alcohol on the snRNAome in vivo , we treated rats with alcohol vapor or left untreated for 7 weeks and measured the expression of snRNAs in the liver by real-time polymerase chain reaction (RT-PCR) using custom-made primers. Blood alcohol concentrations (BACs) levels were three times higher in exposed animals (Supplementary Fig. 2). Importantly, the expression of snU2 was 94% downregulated and snU1 was not changed; snU4 and snU6 were not detected (Fig. 5 ). We also studied the components of the minor spliceosome which is responsible for splicing of atypical snU12-type introns. This specific type of introns constitutes ~ 0.5% of all introns in human genome, and their removal by minor spliceosome is known as non-canonical splicing 50 , 51 . In the minor spliceosome, the expression of snU6atac was completely abolished, and expression of snU11 was 92% reduced; snU12 was not detected (Fig. 5 ). Since in our model alcohol was delivered in the form of vapor, we reasoned that similar changes in snRNA expression may be also observed in the lung. We found that snU2 and snU11, but not snU6-atac, were significantly downregulated in the lung of rats subjected to alcohol vapor (Supplementary Fig. 3), although changes were less drastic than in the liver, indicating that the intensity or mode of alcohol-mediated alteration of the spliceosome could be organ-specific. Effect of alcohol on splicing factors Next, we addressed if alcohol affects expression of splicing factors. Among the main splicing factors with an established link to cancers are SF1, SF3B1, SRSF1, SRSF2, SRSF3, U2AF1, and ZRSR2 27,28 . Analysis of their expression showed no differences between control rats and rats treated with alcohol both in the liver (Fig. 6 ) and the lungs (Supplementary Fig. 4). To determine if these factors were changed in patients with alcohol-related hepatic conditions, we retrieved and analyzed RNA sequencing data from patients with eASH, nsAH, sAH, and exAH and again found no difference between groups (Fig. 6 ). It appears that in contrast to snRNAs which are markedly decreased by alcohol, cancer-related splicing factors remain unaltered. Further, since we observed that many of these factors tended to decrease liver and lung of rats exposed to alcohol (Fig. 6 and Supplementary Fig. 4, P > 0.05), we reasoned that an effort to address the functional status of spliceosome by analyzing only 6 splicing factors may be inaccurate, as it may not fully reflect upon how the whole spliceosome may be affected. We compiled the list of all spliceosomal factors using Gene Set Enrichment Analysis (GSEA) (Supplementary Table 4) and checked if alcohol has a concerted effect on spliceosomal proteome. Although there was a statistically significant reduction in global expression of spliceosomal mRNAome, the magnitude of decrease was only in the range 1–7% (Fig. 7 ) suggesting that protein components of spliceosome are unlikely to be considerably affected by alcohol. Effect of alcohol on splicing-related lncRNAs We observed substantial changes in hepatic lncRNAs in patients with ALD, which correlated with the severity of liver damage. In eASH, 1,108 lncRNAs were differentially expressed, in nsAH – 1854, in sAH – 3,349, and in exAH – 3,353 (Supplementary Fig. 5). Furthermore, the proportion of altered lncRNAs biotypes was different between early and late stages of ALD: while in early stages the pseudogenes were most commonly affected, in non-severe and severe AH stages there was an increased involvement of long intergenic non-coding RNAs and antisense lncRNAs (Supplementary Fig. 5). We then aimed at analyzing if these alterations were also present in alcohol-related HCC. The analysis of gene expression profiles from TCGA showed that patients with HCC + AUD had 514 differentially-expressed lncRNAs in the liver. The comparison of 3,349 lncRNAs altered in sAH with 514 lncRNAs altered in HCC + AUD demonstrated that 101 were common in these two conditions (Supplementary Fig. 6). Finally, a lncRNA ontology revealed that these lncRNAs are functionally related to splicing, as 3 out of 5 top pathways were represented by splicing and RNA processing (Table 2 ). Effect of alcohol on oncogenes To address to what extent alcohol-induced changes in the liver affect oncogenes and tumor suppressors, we aligned 14,100 genes altered in sAH with the list of 803 oncogenes from Oncogene Database 52 . 414 were differentially expressed in both conditions (data not shown) suggesting that alcohol-induced transcriptomic changes in the liver posttranscriptionally affect large portion of all cancer-related genes. At the same time, since different cancers are accompanied by specific oncogenes 53 , 54 , we thought that we should undertake the analysis of oncogenes specific for HCC. In the past few years, extensive efforts by TCGA revealed genes mutated in specific cancers 24 , 55 , 56 , and 26 genes were most commonly mutated in HCC 24 . Screened of these genes using our computational pipeline showed that 7 of them were differentially expressed and/or misspliced in eASH, 14 – in nsAH, 17 – in sAH, and 13 – in exAH (Chi-square test = 8.12, p = 0.04, Table 3 ). Next, we asked if such a dose-dependent effect is limited to cancer-related genes. We compiled and analyzed the list of 26 random genes which included at least one gene from each chromosome. The similar pattern of increase was found: 5 genes were affected in eASH, 8 – nsAH, 9 – in sAH, and 12 – exAH (Chi-square = 4.37, p = 0.22, Supplementary Table 5). Furthermore, we analyzed 26 genes implicated in spermatogenesis (as a pathway unrelated to the liver) and 26 genes involved in gluconeogenesis (as a pathway related to the liver). For both pathways, we once again observed a similar pattern condition-dependent increase: in eASH-nsAH-sAH-exAH continuum, 6-13-13-14 genes were affected in spermatogenesis (Chi-square = 13.91, p = 0.003, Supplementary Table 6) and 7-14-16-14 – in gluconeogenesis (Chi-square = 7.19, p = 0.06, Supplementary Table 7). We reasoned, therefore, that degree of damage is unrelated to the pathway and rather mirrors the number of genes affected in a specific alcohol-related hepatic disease. We set out to merge and count all differentially expressed and misspliced genes in every alcohol-induced liver condition. Results demonstrated that number of affected genes indeed increases with the severity of hepatic damage: 11.8% genes were affected in eASH, 20.1% – in nsAH, 29.8 – in sAH, and 27.7% – in exAH (p = 0, Supplementary Fig. 7). Next, we asked if alcohol use may impart broader transcriptomic changes in HCC and compared gene expression profiles from HCC samples between patients with and without AUD. Analysis showed that patients with HCC + AUD have 2-fold increase in a number of differentially increased genes in comparison to patients with HCC alone (Supplementary Fig. 8). Discussion The salient findings of the current study are: 1) ALD is accompanied by pervasive changes in hepatic transcriptomes; 2) ALD is accompanied by genome-wide changes in splicing and expression of exons; 3) Alcohol suppresses hepatic expression of snRNAs of major and minor spliceosomes; 4) Alcohol does not affect expression of splicing factors; 5) Alcohol affects lncRNAs related to splicing, and 6) Alcohol posttranscriptionally affects genes involved in HCC. In the past few years, alcohol-induced changes in gene expression were relatively well studied in the brain. For example, gene expression profiling on the prefrontal cortex identified 129 altered genes in patients with AUD 57 . It was shown that alcohol-induced changes in the brain are dependent on a cellular lineage, as RNA sequencing demonstrated unique transcriptomic signatures in murine astrocytes 58 or microglial cells 59 . Furthermore, it was demonstrated in mice that alcohol exposure alters expression of microRNAs (miRs) in prefrontal cortex, nucleus accumbens, and amygdala and that affected miRomes matched expression profiles of protein-coding genes in corresponding regions 60 . In the current study, we show that alcohol causes genome-wide changes in the liver, and these changes appear to be far more pervasive than those in the brain as indicated by our own data from different brain regions 41 as well as by results from previous studies 57 – 59 . As of now, it is not known how alcohol may affect gene expression in the liver. Besides splicing, which was the focus of the current study, there are other molecular mechanisms that might be involved. For example, alcohol is associated with aberrant patterns of DNA methylation of CpG islands 61 , 62 and changes in histone code 63 ; as mentioned, alcohol is also capable of changing the expression of miRs which fine-tune the transcriptome in the cytoplasm 60 . Of note, as extent of transcriptomic damage appears to be distinctly different in the liver and brain, it is possible that mechanism of alcohol-induced changes may be organ-specific and should likely be studied separately across specific tissues. Splicing takes a central place in a cellular biology: constitutive splicing is responsible for a removal of introns, and alternative splicing generates a proteomic diversity. We observed that in addition to changes in gene expression, alcohol caused multiple missplicing events. There have been very few studies on the effect of alcohol on splicing, and initial investigations mainly focused on missplicing of specific genes. Thus, alcohol was shown to be associated with a missplicing of AMPA receptors 38 and GABA-B receptors 39 . Ethanol also affected alternative splicing of DRD2 (dopamine D2 receptor) in the pituitary 64 . Later, it was established that alcohol impacts splicing on a broader scale. Kawasawa et al. 40 found 382 alternative splicing events in the brain cortex of human fetuses exposed to alcohol. Qualitatively, 8 missplicing events were detected: 5’-SS, 3’-SS, MEE, IR, cassette exon, coordinate cassette exon, alternative first exon, and alternative last exon (ES was likely not detectable by employed computational pipeline), with IR being the most frequent event. In our previous work, we observed that AUD caused a genome-wide missplicing in different brain regions, most commonly – ES and MEE 41 . In the current study, analysis of hepatic transcriptomes revealed that ES and MEE were again the major alcohol-induced events. These results are different from the missplicing patterns of another alcohol-related cancer, HNSCC, which also was associated with genome-wide changes in splicing, but alternative splice sites (5’-SS and 3’-SS) and canonical exon skipping were the most common missplicing events 65 . It appears that mechanism, extent, and landscape of alcohol-induced missplicing may differ from one tissue to another. Scattered data indicate that aberrant splicing in HCC may be a result of a damaged spliceosome; for example, HCC is frequently associated with mutations in splicing factor SF3B1 24,66 . The effect of alcohol on spliceosome has not been well studied, but indirect evidence suggests that the link between AUD and spliceosomal activity may exist. It was shown that vulnerability of neuroprogenitor cells to toxic effects of alcohol was related to the expression of genes related to spliceosome 67 . It was also shown that exposure of neurons to alcohol reduced the expression of SRSF1 68 . Likewise, in murine placenta and embryos, alcohol affected several spliceosomal genes including SRSF1 69 . In our study, we did not see differential expression in cancer-related splicing factors (SF1, SF3B1, SRSF1, SRSF2, SRSF3, U2AF1, and ZRSR2); neither did we see any change in the expression of all components of the spliceosomal proteome. Instead, we observed that alcohol imparted a marked decrease of snRNAs. That snRNAs were affected and splicing factors were not and it was still induced broad missplicing events suggests a primary role of snRNAs in splicing. It is difficult to address if suppression of snRNAs is the only mechanism of missplicing in AUD. Such an experiment would likely require the “snRNAome rescue” experiment, and a precise normalization snRNAome may be technically hard to achieve. HCC has the second highest worldwide cancer mortality rate, and therapeutic options for metastatic HCC are very limited and modestly efficacious. Many drugs failed to demonstrate efficacy in phase III 70 , likely due to incomplete understanding of mechanisms of HCC in AUD. One explanation of such a poor insight may be a traditional focus on DNA mutations as a driving force of carcinogenesis. Many studies question such an approach. TCGA work on HCC showed that many patients without p53 mutation have inactive functional p53 24 suggesting that oncogenes may be affected via posttranscriptional mechanism, including splicing. HCC was previously shown to be accompanied by a dysregulated expression of splice isoforms of various genes including DNMT3b, TP53, KLF6 71 , ketohexokinase 72 , and hepcidin 73 . It is possible that AUD-induced HCC represents a separate entity different from, for example, HCC associated with hepatitis C. Such a scenario was shown for esophageal squamous cell carcinoma in which genome sequencing identified six mutational signatures, with one of them specifically linked to alcohol intake 74 . Clearly, other genetic and epigenetic mechanisms are implicated and should be evaluated. For example, it was found that impaired functional status of p53 protein in patients with HCC and non-mutated TP53 could at least partly be attributed to high levels of MDM4, a p53 inhibitor 24 . One could speculate that each of tumor suppressors (oncogenes) involved in HCC may have protein inhibitors (activators). Also, it was shown that alcohol affects such processes related to gene-to-protein flow as RNA transport, ribosomes, and protein processing in the endoplasmic reticulum 67 , and it might be of interest to assess a relative contribution of these mechanisms in processing of HCC-related genes. In the current study, patients with eASH, nsAH, sAH, and exAH did not differ in terms of alcohol use which is in line with previous findings demonstrating the lack of correlation between alcohol intake and incidence/severity of AH 75 , 76 . Why are transcriptional and splicing landscapes so different in patients with similar alcohol intake? One may speculate that it is likely related to a genetic predisposition to missplicing. Since splicing is regulated by spliceosome, culprit(s) should be either snRNAs and/or splicing factors. We observed that splicing factors were not affected in all groups. We did not analyze snRNAome in human RNA sequencing datasets, but we cannot rule out the possibility that mutations in genomic snRNAs genes may be involved, and this would warrant a further investigation. It is of interest that both spliceosomes were affected in mice exposed to alcohol suggesting a common mechanism by which AUD may downregulate spliceosomes. Such a mechanism may involve transcription factor(s) orchestrating transcription of snRNAs. Another, posttranscriptional, mechanism of regulation may be represented by lncRNAs. Spliceosome represents a gigantic machinery consisting of snRNAs and splicing factors, and it is functionally coupled with gene expression 77 . Since lncRNAs can interact with DNA, RNA, and proteins, it is possible that they serve as master regulator of spliceosome. In our work, distribution of altered lncRNAomes differed between groups, with pseudogenes dominating early phase of alcohol-induced hepatic damage and lincRNAs and antisense lncRNA – later phases. Some evidence indicates that even individual lncRNAs may cause changes in splicing. Thus, lncRNA MALAT1, an established oncogene activated in many cancers including HCC 78 and also upregulated in the brain of alcoholics 79 , affected splicing factors HNRNPF and HNRNPF1 as well as levels of serine-arginine-rich splicing factors and affected alternative splicing of hundreds of transcripts 80 . Alternative splicing is globally regulated by sno-lncRNAs, lncRNA flanked by small nucleolar RNA (snoRNAs) 81 which are a family of conserved nuclear RNAs located in Cajal bodies or nucleoli and participating in snRNAs modifications. Several lncRNAs are able to interact with specific splicing factors 82 . New exciting field is represented by circular RNAs (circRNAs), a covalently closed single-stranded RNA complexes arising from back-splicing. These complexes are highly stable, and it is speculated that they might be capable of competing with pre-mRNA for spliceosome 83 . We interrogated lncRNAs and found that lncRNAs affected in AUD and HCC + AUD were functionally related to splicing. The link between lncRNAs and spliceosomes is currently unknown. One possibility is that lncRNAs may function as “snRNAs sponges”, as a similar function was described for circRNAs which are capable of “sponging” miRs 84 . Our tentative model is shown in Fig. 8 . We showed that alcohol perturbs gene expression and splicing in genome-wide fashion across all alcohol-related hepatic diseases. Mechanistically, missplicing appears to be mediated by suppression of snRNAs of major and minor spliceosome. ALD was also associated with altered expression of lncRNAs, but the link between lncRNAs and spliceosome is to be elucidated. Among affected genes are oncogenes and tumor suppressors implicated in the development and progression of HCC. Materials and Methods Patients All experiments have been conducted in accordance with the guidelines and regulations of Ethics Committees and Institutional Review Boards of the University of Miami and Linkoping University. RNA sequencing files from liver samples were obtained from the multicentric NIH-funded InTEAM Consortium and are available in the Database of Genotypes and Phenotypes (dbGAP, phs001807) 44 . Patients with non-severe (nsAH) and severe alcoholic hepatitis (sAH) as well as patients with liver failure who underwent liver transplantation were enrolled in the Consortium centers in Europe and United States. Samples from patients with early alcoholic steatohepatitis (eASH) were obtained from Cliniques Universitaires Saint-Luc (Brussels, Belgium). In total, 62 patients were included in this study. Written informed consent was obtained from all patients, and research protocols were approved by the local Ethics Committees and by the central Institutional Review Board of the University of North Carolina at Chapel Hill. Patients were selected according to different clinically relevant stage groups: patients with eASH who were non-obese with high alcohol intake and presented with a mild elevation of transaminases and histologic criteria of steatohepatitis (n = 12); patients with nsAH and sAH who were biopsied before any treatment (n = 11 for nsAH and n = 18 for sAH); and explants from patients with AH who underwent early transplantation due to a liver failure following a well-defined protocol 85 (exAH, n = 11). Samples from these groups were compared with fragments of non-diseased human livers (n = 10). Patients with malignancies were excluded from the study. Sequencing of RNA from liver samples Sequencing was performed using Illumina HiSeq2000 platform, as previously described 44 . Briefly, libraries were built using Illumina TruSeq Stranded Total RNA Ribo-Zero GOLD (Illumina). Sequencing was paired and multiplexed. 62 paired-end sequenced samples obtained an average of 36,9 million total reads. Analysis of Transcriptome Alignment was performed with the STAR aligner (v.2.5.2a) against the hg19 human genome. Adapters were trimmed by TrimGalore. Raw counts were processed by the Bioconductor R package edgeR and normalized using the TMM method to produce CPM values. Differential expression was calculated using a negative binomial model, and a False Discovery Ratio (FDR) cutoff of < 0.05 was used to define statistical significance. Next, we analyzed consistent transcriptomic changes across all groups using the Bayesian ANOVA for microarrays (BAM) methodology developed by our group 86 which employs a specific Bayesian hierarchical model oriented towards adaptive shrinkage. By using model averaging, BAM-provided gene effect estimates are shrunken relative to the standard least square estimates. In this process, primarily the non-differentially expressing gene effects are shrunken. Such a selective shrinkage enabled BAM to optimally balance the total false detections (total number of genes falsely identified as being differentially expressed) against total false non-detections (the total number of genes falsely identified as being non-differentially expressed). This model enabled BAM to use data across all genes and all experimental groups to accurately estimate different levels of sparsity and then to selectively shrink gene effects based on the estimated complexities. BAM estimated gene differential effects (Zcut values) represented the products of posterior inference from the BAM hierarchical Bayesian model. Shrinkage plots were used to identify differentially expressed genes. Significant genes were grouped by differential expression pattern type. Gene Ontology of protein-coding genes Functional analysis of altered transcripts was performed by Gene Ontology Consortium, as described elsewhere 87 , 88 . Hierarchy of implicated Gene Ontology terms was constructed using default criteria set by developers. Analysis of missplicing events Alignment was performed with the STAR aligner (v.2.5.2a) against the hg19 human genome. Resulting bam files from the STAR alignment were indexed with samtools for use by rMATS, as described elsewhere 45 . Briefly, rMATS pipeline used RNA sequencing reads which were mapped to different splice variants to estimate the isoform proportion, and a hierarchical framework was employed to simultaneously account for estimation uncertainty in individual replicates and variability among replicates. FDR cutoff < 0.05 was used to define statistical significance. Exon expression Analysis of the expression of exons was performed as described elsewhere 89 . Alignment was performed with the STAR aligner (v.2.5.2a) against the hg19 human genome. Adapters were trimmed by TrimGalore. Raw counts were obtained from the dexseq_count.py script contained in the DEXSeq R package (v.1.20.2) on the reference annotation prepared by the dexseq_prepare_annotation.py script in the same package against the GENCODE reference file (v.19). These counts were then fed into DEXSeq to determine exon-specific differential splicing events. Figures were generated using the plotDEXSeq function contained in the DEXSeq package. FDR cutoff < 0.05 was used to define statistical significance. Rat model of alcohol use disorder based on vapor chamber Experiments on animals have been approved by the Institutional Review Board of the Linkoping University and have been carried out in full accord with relevant guidelines and regulations. All methods are reported in accordance with ARRIVE guidelines and regulations 90 . Rats were placed in a vapor chamber with a normal air for one week for a habituation to a new environment (two rats per cage). Then alcohol vapor exposure was slowly increased in the course of 1 week until blood alcohol concentration (BAC) reached ~ 200 mg/dL. Rats were exposed to alcohol vapor for 7 weeks (5 days a week, 14 hours/day) or left unexposed (n = 12 in each group). BAC was measured once per week from one rat per cage (rats were alternating every other week). One week after the last alcohol exposure, animals were sacrificed, and liver and lung samples were collected. RNA isolation RNA was isolated from liver and lung by Qiagen RNeasy kit, in accordance to manufacturer’s instructions. Prior to RNA isolation, samples were incubated in RNAlater-ICE (Thermo Fisher Scientific) overnight at -20°C. DNase treatment was performed using RNase-Free DNase Set (Qiagen). RNA quality and concentrations were determined by Nanodrop 2000, and samples with RNA Integrity Number (A260:A280 ratio) between 1.9–2.1 were included in the study. RNA samples were kept at -80°C until analyzed. Quantitative real-time PCR (qRT-PCR) RNA was reversely transcribed using High Capacity cDNA Reverse Transcription Kit (Thermo Fisher Scientific); reactions were run on a Veriti 96 Well Fast Thermal Cycler (Applied Biosystems); cycling conditions were 25°C for 10 minutes, 37°C for 2 hours, and 85°C for 5 minutes. For real-time PCR, cDNA was mixed with a master mix consisting of TaqMan Universal PCR Master Mix (Roche), nuclease-free water, and 20X or 40 X TaqMan primers. qRT-PCR was performed on QuantStudio 6 Flex (Thermo Fisher Scientific) using probe-based assays from Integrated DNA Technologies. Cycling conditions were 50°C for 2 minutes, 95°C for 10 minutes, and 40 cycles of 95°C for 15 seconds and 60°C for 1 minute. Data were analyzed using the comparative threshold cycle (ΔΔCT) method, as described previously 91 , normalized to β-actin, and expressed relatively to a control group. Primers for protein-coding genes were purchased from a pre-made stock of Integrated DNA Technologies. Primers for human and rat snRNAs were designed either by ourselves or by Integrated DNA Technologies, and their sequences are listed in Supplementary Table 8. Computational Analysis of Coding and Non-coding Features The Cancer Genome Atlas (TCGA, www.cancer.gov/tcga ) was used to retrieve RNA sequencing files from patients with HCC and HCC + AUD. For most patients with HCC, alcohol intake was well documented on TCGA; however, since DSM-5-defined criteria of AUD were not included in TCGA social history, we arbitrarily defined AUD group as individuals consuming 4 or more drinks a day at least 4 days a week; control group included subjects with no alcohol intake. Other inclusion criterion was being alive at the time of cancerous tissue harvest (to avoid possible RNA degradation in postmortem samples). 10 patients were included in each group. All datasets incorporated in the analysis were generated by aligning reads to GRCh38 using STAR; genes were annotated using GENCODE v.22, and their expression was presented in a FPKM-UQ format. Gene Set Enrichment Analysis database 92 was used to obtain the list of spliceosomal proteins and to create the lists of proteins involved in gluconeogenesis and spermatogenesis as well as the list of 26 random genes which included at least 1 gene from each chromosome. List of cancer-related genes was retrieved form the Oncogene Database 52 , a literature-based curated database of oncogenes and tumor suppressors. Functional status of altered lncRNAs of interest was studied using “LncRNA Ontology” database 93 which employs the pipeline based on transcriptional and epigenetic profiles of lncRNAs and protein-coding genes; default criteria set by developers were used to execute the ontology. Statistical Analysis Statistical analysis between two groups was performed using two-tailed Student’s t test. Data are expressed as mean ± SEM unless otherwise stated. Proportions in events in different groups were assessed using chi-square test; rejection of the null hypothesis (that proportions are the same across groups) indicated that proportion is different in at least one group. Difference between expression of splicing factors was determined using the Test for Fold Change of Two Means. Differences with P < 0.05 were considered to be statistically significant. Declarations Sources of funding This work was supported by HIN grant R01AA029924. Competing Interests Statement The authors declare no competing interests. Author Contribution IOB, DVB, and CW developed the concept and designed the study; IOB, DVB, JA, ML, JSR, EB, EB, MH, and RB collected and/or analyzed datasets; IOB, DVB, JC, ABD, and CW interpreted results; IOB and CW wrote the manuscript. Data Availability RNA sequencing files from liver samples were obtained from the multicentric NIH-funded InTEAM Consortium and are available in the Database of Genotypes and Phenotypes (dbGAP, phs001807). References Anderson, B. O. et al. Health and cancer risks associated with low levels of alcohol consumption. Lancet Public. Health . 8 , e6–e7. 10.1016/s2468-2667(22)00317-6 (2023). Grant, B. F. et al. Epidemiology of DSM-5 Alcohol Use Disorder: Results From the National Epidemiologic Survey on Alcohol and Related Conditions III. JAMA Psychiatry . 72 , 757–766. 10.1001/jamapsychiatry.2015.0584 (2015). Grant, B. F. et al. Prevalence of 12-Month Alcohol Use, High-Risk Drinking, and DSM-IV Alcohol Use Disorder in the United States, 2001–2002 to 2012–2013: Results From the National Epidemiologic Survey on Alcohol and Related Conditions. JAMA psychiatry 74, 911–923, (2017). 10.1001/jamapsychiatry.2017.2161 Mekonen, T. et al. Treatment rates for alcohol use disorders: a systematic review and meta-analysis. Addiction 116 , 2617–2634. 10.1111/add.15357 (2021). Crowley, R., Hilden, D. & Beachy, M. Excessive Alcohol Use and Alcohol Use Disorders: A Policy Brief of the American College of Physicians. Ann. Intern. Med. 177 , 656–657. 10.7326/m23-3434 (2024). Sacks, J. J., Gonzales, K. R., Bouchery, E. E., Tomedi, L. E. & Brewer, R. D. 2010 National and State Costs of Excessive Alcohol Consumption. Am. J. Prev. Med. 49 , e73–e79. 10.1016/j.amepre.2015.05.031 (2015). Li, M., Peterson, C., Xu, L., Mikosz, C. A. & Luo, F. Medical Costs of Substance Use Disorders in the US Employer-Sponsored Insurance Population. JAMA Netw. Open. 6 , e2252378. 10.1001/jamanetworkopen.2022.52378 (2023). Seitz, H. K. et al. Alcoholic liver disease. Nat. Rev. Dis. Primers . 4 , 16. 10.1038/s41572-018-0014-7 (2018). Mittal, S. et al. Hepatocellular Carcinoma in the Absence of Cirrhosis in United States Veterans is Associated With Nonalcoholic Fatty Liver Disease. Clin. Gastroenterol. hepatology: official Clin. Pract. J. Am. Gastroenterological Association . 14 , 124–131e121. 10.1016/j.cgh.2015.07.019 (2016). Tokushige, K. et al. Hepatocellular carcinoma in Japanese patients with nonalcoholic fatty liver disease and alcoholic liver disease: multicenter survey. J. Gastroenterol. 51 , 586–596. 10.1007/s00535-015-1129-1 (2016). Bosetti, C., Turati, F. & La Vecchia, C. Hepatocellular carcinoma epidemiology. Best Pract. Res. Clin. Gastroenterol. 28 , 753–770. 10.1016/j.bpg.2014.08.007 (2014). Samant, H., Amiri, H. S. & Zibari, G. B. Addressing the worldwide hepatocellular carcinoma: epidemiology, prevention and management. J. Gastrointest. Oncol. 12 , S361–s373. 10.21037/jgo.2020.02.08 (2021). Llovet, J. M. et al. Sorafenib in advanced hepatocellular carcinoma. N. Engl. J. Med. 359 , 378–390. 10.1056/NEJMoa0708857 (2008). Kudo, M. et al. Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial. Lancet 391 , 1163–1173. 10.1016/s0140-6736(18)30207-1 (2018). El-Khoueiry, A. B. et al. Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial. Lancet (London England) . 389 , 2492–2502. 10.1016/s0140-6736(17)31046-2 (2017). Abou-Alfa, G. K. et al. Tremelimumab plus Durvalumab in Unresectable Hepatocellular Carcinoma. NEJM Evid. 1 , EVIDoa2100070. 10.1056/EVIDoa2100070 (2022). Brown, Z. J. et al. Management of Hepatocellular Carcinoma: A Review. JAMA Surg. 158 , 410–420. 10.1001/jamasurg.2022.7989 (2023). Dhanasekaran, R., Limaye, A. & Cabrera, R. Hepatocellular carcinoma: current trends in worldwide epidemiology, risk factors, diagnosis, and therapeutics. Hepatic medicine: Evid. Res. 4 , 19–37. 10.2147/hmer.S16316 (2012). Oh, J. H. & Jun, D. W. The latest global burden of liver cancer: A past and present threat. Clin. Mol. Hepatol. 29 , 355–357. 10.3350/cmh.2023.0070 (2023). Hassan, M. M. et al. Risk factors for hepatocellular carcinoma: synergism of alcohol with viral hepatitis and diabetes mellitus. Hepatology 36 , 1206–1213. 10.1053/jhep.2002.36780 (2002). Chuang, S. C., Lee, Y. C., Wu, G. J., Straif, K. & Hashibe, M. Alcohol consumption and liver cancer risk: a meta-analysis. Cancer Causes Control . 26 , 1205–1231. 10.1007/s10552-015-0615-3 (2015). Marot, A., Henrion, J., Knebel, J. F., Moreno, C. & Deltenre, P. Alcoholic liver disease confers a worse prognosis than HCV infection and non-alcoholic fatty liver disease among patients with cirrhosis: An observational study. PloS one . 12 , e0186715. 10.1371/journal.pone.0186715 (2017). West, J., Card, T. R., Aithal, G. P. & Fleming, K. M. Risk of hepatocellular carcinoma among individuals with different aetiologies of cirrhosis: a population-based cohort study. Aliment. Pharmacol. Ther. 45 , 983–990. 10.1111/apt.13961 (2017). Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma. Cell 169 , 1327–1341e1323, doi: 10.1016/j.cell.2017.05.046 (2017). Ramadori, P., Cubero, F. J., Liedtke, C., Trautwein, C. & Nevzorova, Y. A. Alcohol and Hepatocellular Carcinoma: Adding Fuel to the Flame. Cancers 9 10.3390/cancers9100130 (2017). Will, C. L. & Luhrmann, R. Spliceosome structure and function. Cold Spring Harb Perspect. Biol. 3 10.1101/cshperspect.a003707 (2011). Anczukow, O. & Krainer, A. R. Splicing-factor alterations in cancers. RNA (New York N Y) . 22 , 1285–1301. 10.1261/rna.057919.116 (2016). Dvinge, H., Kim, E., Abdel-Wahab, O. & Bradley, R. K. RNA splicing factors as oncoproteins and tumour suppressors. Nat. Rev. Cancer . 16 , 413–430. 10.1038/nrc.2016.51 (2016). Zhang, Q., Ai, Y. & Abdel-Wahab, O. Molecular impact of mutations in RNA splicing factors in cancer. Mol. Cell. 84 , 3667–3680. 10.1016/j.molcel.2024.07.019 (2024). Wahl, M. C., Will, C. L. & Luhrmann, R. The spliceosome: design principles of a dynamic RNP machine. Cell 136 , 701–718. 10.1016/j.cell.2009.02.009 (2009). Twyffels, L., Gueydan, C., Kruys, V. & Shuttling SR proteins: more than splicing factors. FEBS J. 278 , 3246–3255. 10.1111/j.1742-4658.2011.08274.x (2011). Madan, V. et al. Aberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome. Nat. Commun. 6 , 6042. 10.1038/ncomms7042 (2015). Okeyo-Owuor, T. et al. U2AF1 mutations alter sequence specificity of pre-mRNA binding and splicing. Leukemia 29 , 909–917. 10.1038/leu.2014.303 (2015). Blokhin, I., Khorkova, O., Hsiao, J. & Wahlestedt, C. Developments in lncRNA drug discovery: where are we heading? Expert Opin. Drug Discov . 13 , 837–849. 10.1080/17460441.2018.1501024 (2018). Tsuiji, H. et al. Competition between a noncoding exon and introns: Gomafu contains tandem UACUAAC repeats and associates with splicing factor-1. Genes cells: devoted Mol. Cell. Mech. 16 , 479–490. 10.1111/j.1365-2443.2011.01502.x (2011). Bernard, D. et al. A long nuclear-retained non-coding RNA regulates synaptogenesis by modulating gene expression. EMBO J. 29 , 3082–3093. 10.1038/emboj.2010.199 (2010). Tripathi, V. et al. The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation. Mol. Cell . 39 , 925–938. 10.1016/j.molcel.2010.08.011 (2010). Acosta, G., Freidman, D. P., Grant, K. A. & Hemby, S. E. Alternative splicing of AMPA subunits in prefrontal cortical fields of cynomolgus monkeys following chronic ethanol self-administration. Front. Psychiatry . 2 , 72. 10.3389/fpsyt.2011.00072 (2011). Lee, C., Mayfield, R. D. & Harris, R. A. Altered gamma-aminobutyric acid type B receptor subunit 1 splicing in alcoholics. Biol. Psychiatry . 75 , 765–773. 10.1016/j.biopsych.2013.08.028 (2014). Kawasawa, Y. I. et al. Genome-wide profiling of differentially spliced mRNAs in human fetal cortical tissue exposed to alcohol. Alcohol (Fayetteville N Y) . 62 , 1–9. 10.1016/j.alcohol.2017.05.001 (2017). Van Booven, D. et al. Alcohol use disorder causes global changes in splicing in the human brain. Transl Psychiatry . 11 , 2. 10.1038/s41398-020-01163-z (2021). Tremblay, M. P. et al. Global profiling of alternative RNA splicing events provides insights into molecular differences between various types of hepatocellular carcinoma. BMC Genom. 17 10.1186/s12864-016-3029-z (2016). Zhu, G. Q. et al. Prognostic alternative mRNA splicing signature in hepatocellular carcinoma: a study based on large-scale sequencing data. Carcinogenesis 10.1093/carcin/bgz073 (2019). Argemi, J. et al. Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis. Nat. Commun. 10 , 3126. 10.1038/s41467-019-11004-3 (2019). Shen, S. et al. rMATS: robust and flexible detection of differential alternative splicing from replicate RNA-Seq data. Proc. Natl. Acad. Sci. U.S.A. 111 , E5593–5601. 10.1073/pnas.1419161111 (2014). Morais, P., Adachi, H. & Yu, Y. T. Spliceosomal snRNA Epitranscriptomics. Front. Genet. 12 , 652129. 10.3389/fgene.2021.652129 (2021). Valadkhan, S. Role of the snRNAs in spliceosomal active site. RNA Biol. 7 , 345–353. 10.4161/rna.7.3.12089 (2010). Huggett, S. B., Ikeda, A. S., Yuan, Q., Benca-Bachman, C. E. & Palmer, R. H. C. Genome- and transcriptome-wide splicing associations with alcohol use disorder. Sci. Rep. 13 , 3950. 10.1038/s41598-023-30926-z (2023). Schmidt-Heck, W. et al. Global Transcriptional Response of Human Liver Cells to Ethanol Stress of Different Strength Reveals Hormetic Behavior. Alcohol. Clin. Exp. Res. 41 , 883–894. 10.1111/acer.13361 (2017). Zhao, J., Peter, D., Brandina, I., Liu, X. & Galej, W. P. Structural basis of 5' splice site recognition by the minor spliceosome. Mol. Cell. 85 , 652–664e654. 10.1016/j.molcel.2024.12.017 (2025). Turunen, J. J., Niemela, E. H., Verma, B. & Frilander, M. J. The significant other: splicing by the minor spliceosome. Wiley Interdiscip Rev. RNA . 4 , 61–76. 10.1002/wrna.1141 (2013). Liu, Y., Sun, J., Zhao, M. & ONGene A literature-based database for human oncogenes. J. Genet. genomics = Yi chuan xue bao . 44 , 119–121. 10.1016/j.jgg.2016.12.004 (2017). Wang, F., Breslin, S. J. P. & Qiu, W. Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma. Liver Res. 5 , 195–203. 10.1016/j.livres.2021.06.001 (2021). Breves, S. L. et al. Three-dimensional regulatory hubs support oncogenic programs in glioblastoma. Mol. Cell. 85 , 1330–1348e1336. 10.1016/j.molcel.2025.03.007 (2025). Integrated genomic characterization of oesophageal carcinoma. Nature 541 , 169–175, doi: 10.1038/nature20805 (2017). Integrated genomic and molecular characterization of cervical cancer. Nature 543 , 378–384, doi: 10.1038/nature21386 (2017). Kapoor, M. et al. Analysis of whole genome-transcriptomic organization in brain to identify genes associated with alcoholism. Transl Psychiatry . 9 , 89. 10.1038/s41398-019-0384-y (2019). Erickson, E. K., Farris, S. P., Blednov, Y. A., Mayfield, R. D. & Harris, R. A. Astrocyte-specific transcriptome responses to chronic ethanol consumption. pharmacogenomics J. 18 , 578–589. 10.1038/s41397-017-0012-2 (2018). McCarthy, G. M., Farris, S. P., Blednov, Y. A., Harris, R. A. & Mayfield, R. D. Microglial-specific transcriptome changes following chronic alcohol consumption. Neuropharmacology 128 , 416–424. 10.1016/j.neuropharm.2017.10.035 (2018). Osterndorff-Kahanek, E. A. et al. Long-term ethanol exposure: Temporal pattern of microRNA expression and associated mRNA gene networks in mouse brain. PloS one . 13 , e0190841. 10.1371/journal.pone.0190841 (2018). Liu, C. et al. A DNA methylation biomarker of alcohol consumption. Mol. Psychiatry . 23 , 422–433. 10.1038/mp.2016.192 (2018). Zheng, Q., Wang, H., Yan, A., Yin, F. & Qiao, X. DNA Methylation in Alcohol Use Disorder. Int. J. Mol. Sci. 24 10.3390/ijms241210130 (2023). Park, P. H., Miller, R. & Shukla, S. D. Acetylation of histone H3 at lysine 9 by ethanol in rat hepatocytes. Biochem. Biophys. Res. Commun. 306 , 501–504 (2003). Oomizu, S., Boyadjieva, N. & Sarkar, D. K. Ethanol and estradiol modulate alternative splicing of dopamine D2 receptor messenger RNA and abolish the inhibitory action of bromocriptine on prolactin release from the pituitary gland. Alcohol. Clin. Exp. Res. 27 , 975–980. 10.1097/01.Alc.0000071743.57855.Be (2003). Guo, T. et al. A Novel Functional Splice Variant of AKT3 Defined by Analysis of Alternative Splice Expression in HPV-Positive Oropharyngeal Cancers. Cancer Res. 77 , 5248–5258. 10.1158/0008-5472.Can-16-3106 (2017). Bejar, R. Splicing Factor Mutations in Cancer. Adv. Exp. Med. Biol. 907 , 215–228. 10.1007/978-3-319-29073-7_9 (2016). Garic, A., Berres, M. E. & Smith, S. M. High-throughput transcriptome sequencing identifies candidate genetic modifiers of vulnerability to fetal alcohol spectrum disorders. Alcohol. Clin. Exp. Res. 38 , 1874–1882. 10.1111/acer.12457 (2014). Sariyer, R. et al. Alcohol-Mediated Missplicing of Mcl-1 Pre-mRNA is Involved in Neurotoxicity. Alcohol. Clin. Exp. Res. 41 , 1715–1724. 10.1111/acer.13474 (2017). Downing, C. et al. Gene expression changes in C57BL/6J and DBA/2J mice following prenatal alcohol exposure. Alcohol. Clin. Exp. Res. 36 , 1519–1529. 10.1111/j.1530-0277.2012.01757.x (2012). Llovet, J. M. & Hernandez-Gea, V. Hepatocellular carcinoma: reasons for phase III failure and novel perspectives on trial design. Clin. cancer research: official J. Am. Association Cancer Res. 20 , 2072–2079. 10.1158/1078-0432.Ccr-13-0547 (2014). Berasain, C. et al. Impairment of pre-mRNA splicing in liver disease: mechanisms and consequences. World J. Gastroenterol. 16 , 3091–3102. 10.3748/wjg.v16.i25.3091 (2010). Li, X. et al. A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation. Nat. Cell Biol. 18 , 561–571. 10.1038/ncb3338 (2016). Toki, Y. et al. A selective splicing variant of hepcidin mRNA in hepatocellular carcinoma cell lines. Biochem. Biophys. Res. Commun. 476 , 501–507. 10.1016/j.bbrc.2016.05.153 (2016). Chang, J. et al. Genomic analysis of oesophageal squamous-cell carcinoma identifies alcohol drinking-related mutation signature and genomic alterations. Nat. Commun. 8 , 15290. 10.1038/ncomms15290 (2017). Liangpunsakul, S. et al. Effects of Age, Sex, Body Weight, and Quantity of Alcohol Consumption on Occurrence and Severity of Alcoholic Hepatitis. Clin. Gastroenterol. hepatology: official Clin. Pract. J. Am. Gastroenterological Association . 14 , 1831–1838e1833. 10.1016/j.cgh.2016.05.041 (2016). Sozio, M. S., Liangpunsakul, S. & Crabb, D. The role of lipid metabolism in the pathogenesis of alcoholic and nonalcoholic hepatic steatosis. Semin. Liver Dis. 30 , 378–390. 10.1055/s-0030-1267538 (2010). Tholen, J. & Galej, W. P. Structural studies of the spliceosome: Bridging the gaps. Curr. Opin. Struct. Biol. 77 , 102461. 10.1016/j.sbi.2022.102461 (2022). Malakar, P. et al. Long Noncoding RNA MALAT1 Promotes Hepatocellular Carcinoma Development by SRSF1 Upregulation and mTOR Activation. Cancer Res. 77 , 1155–1167. 10.1158/0008-5472.Can-16-1508 (2017). Kryger, R., Fan, L., Wilce, P. A. & Jaquet, V. MALAT-1, a non protein-coding RNA is upregulated in the cerebellum, hippocampus and brain stem of human alcoholics. Alcohol (Fayetteville N Y) . 46 , 629–634. 10.1016/j.alcohol.2012.04.002 (2012). Cardamone, G. et al. Not only cancer: the long non-coding RNA MALAT1 affects the repertoire of alternatively spliced transcripts and circular RNAs in multiple sclerosis. Hum. Mol. Genet. 28 , 1414–1428. 10.1093/hmg/ddy438 (2019). Yin, Q. F. et al. Long noncoding RNAs with snoRNA ends. Mol. Cell . 48 , 219–230. 10.1016/j.molcel.2012.07.033 (2012). Romero-Barrios, N., Legascue, M. F., Benhamed, M., Ariel, F. & Crespi, M. Splicing regulation by long noncoding RNAs. Nucleic Acids Res. 46 , 2169–2184. 10.1093/nar/gky095 (2018). Chen, L. L. The biogenesis and emerging roles of circular RNAs. Nat. Rev. Mol. Cell Biol. 17 , 205–211. 10.1038/nrm.2015.32 (2016). Hansen, T. B. et al. Natural RNA circles function as efficient microRNA sponges. Nature 495 , 384–388. 10.1038/nature11993 (2013). Mathurin, P. et al. Early liver transplantation for severe alcoholic hepatitis. N. Engl. J. Med. 365 , 1790–1800. 10.1056/NEJMoa1105703 (2011). Ishwaran, H., Rao, J. S. & Kogalur, U. B. BAMarraytrade mark: Java software for Bayesian analysis of variance for microarray data. BMC Bioinform. 7 , 59. 10.1186/1471-2105-7-59 (2006). The Gene Ontology Resource. 20 years and still GOing strong. Nucleic Acids Res. 47 , D330–d338. 10.1093/nar/gky1055 (2019). Ashburner, M. et al. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat. Genet. 25 , 25–29. 10.1038/75556 (2000). Anders, S., Reyes, A. & Huber, W. Detecting differential usage of exons from RNA-seq data. Genome Res. 22 , 2008–2017. 10.1101/gr.133744.111 (2012). Percie du Sert. Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0. PLoS Biol. 18 , e3000411. 10.1371/journal.pbio.3000411 (2020). Livak, K. J. & Schmittgen, T. D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (San Diego Calif) . 25 , 402–408. 10.1006/meth.2001.1262 (2001). Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. U S A . 102 , 15545–15550. 10.1073/pnas.0506580102 (2005). Li, Y. et al. LncRNA ontology: inferring lncRNA functions based on chromatin states and expression patterns. Oncotarget 6 , 39793–39805. 10.18632/oncotarget.5794 (2015). Tables Table 2. LncRNA Ontology of LncRNAs Altered in sAH and HCC+AUD Biological Process Number of lncRNAs mRNA splicing, via spliceosome 23 DNA repair 21 RNA processing 19 mRNA processing 18 DNA metabolic process 17 Table 3. Oncogenes Affected in the Liver of Patients with Various Stages of Alcohol-induced Damage Transcript eASH nsAH sAH exAH TP53 x x x CTNNB1 x x x ALB x x x x AXIN1 x x x BAP1 x x KEAP1 NFE2L2 LZTR1 RB1 x x x PIK3CA RPS6KA3 x x x AZIN1 x x KRAS x x x IL6ST x x x x RP1L1 x CDKN2A x x x EEF1A1 x x ARID2 ARID1A x x x x GPATCH4 ACVR2A APOB x x x x CREB3L3 x x x x NRAS x AHCTF1 x x HIST1H1C 7 14 17 13 Additional Declarations No competing interests reported. Supplementary Files SupplementaryTableS2.OverlappingDownregulatedTranscriptomeineASHandexAH.xlsx SupplementaryTableS4.ListofSpliceosomalGenes.xlsx SupplementaryTableS6.GenesInvolvedinSpermatogenesis.xlsx SupplementaryTableS1.OverlappingDownregulatedTranscriptomeineASHandsAH.xlsx SupplementaryTableS5.GenesfromDifferentChromosomes.xlsx SupplementaryTableS7.GenesInvolvedinGluconeogenesis.xlsx SupplementaryTableS3.ConsistentTranscriptomicChanges.xlsx SupplementaryTableS8.snRNAsprimers.xlsx SupplementaryFiguresS1S8.docx Cite Share Download PDF Status: Under Review Version 1 posted Editorial decision: Revision requested 14 Oct, 2025 Reviews received at journal 08 Oct, 2025 Reviews received at journal 07 Oct, 2025 Reviews received at journal 05 Oct, 2025 Reviewers agreed at journal 18 Sep, 2025 Reviewers agreed at journal 17 Sep, 2025 Reviewers agreed at journal 16 Sep, 2025 Reviewers agreed at journal 16 Sep, 2025 Reviewers invited by journal 16 Sep, 2025 Editor assigned by journal 16 Sep, 2025 Editor invited by journal 16 Sep, 2025 Submission checks completed at journal 26 Aug, 2025 First submitted to journal 26 Aug, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7380649","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":518470902,"identity":"f37fa6d8-44d1-4e33-a3f8-93dd130fc86b","order_by":0,"name":"Ilya O. Blokhin","email":"","orcid":"","institution":"Harvard University","correspondingAuthor":false,"prefix":"","firstName":"Ilya","middleName":"O.","lastName":"Blokhin","suffix":""},{"id":518470903,"identity":"7e299511-3870-4568-9cf5-6a88de8f3193","order_by":1,"name":"Derek Van Booven","email":"","orcid":"","institution":"University of Miami","correspondingAuthor":false,"prefix":"","firstName":"Derek","middleName":"Van","lastName":"Booven","suffix":""},{"id":518470904,"identity":"dfe818f1-b536-4eeb-83a5-3be2a5c0a776","order_by":2,"name":"Josepmaria Argemi","email":"","orcid":"","institution":"University of Pittsburgh","correspondingAuthor":false,"prefix":"","firstName":"Josepmaria","middleName":"","lastName":"Argemi","suffix":""},{"id":518470905,"identity":"bd636c40-f28a-4b41-88a7-085ee0562c62","order_by":3,"name":"Mengying Li","email":"","orcid":"","institution":"University of Miami","correspondingAuthor":false,"prefix":"","firstName":"Mengying","middleName":"","lastName":"Li","suffix":""},{"id":518470907,"identity":"4c641605-03c4-4582-9dfb-f6b715163b25","order_by":4,"name":"J. Sunil Rao","email":"","orcid":"","institution":"University of Miami","correspondingAuthor":false,"prefix":"","firstName":"J.","middleName":"Sunil","lastName":"Rao","suffix":""},{"id":518470909,"identity":"6eca2004-3bb7-4926-978f-e60936d24a75","order_by":5,"name":"Estelle Barbier","email":"","orcid":"","institution":"Linkoping University","correspondingAuthor":false,"prefix":"","firstName":"Estelle","middleName":"","lastName":"Barbier","suffix":""},{"id":518470910,"identity":"2be76c9d-5a4b-443f-86ab-e6dfed9b2a2a","order_by":6,"name":"Markus Heilig","email":"","orcid":"","institution":"Linkoping University","correspondingAuthor":false,"prefix":"","firstName":"Markus","middleName":"","lastName":"Heilig","suffix":""},{"id":518470911,"identity":"6a24cf37-299a-4f7e-b92b-10ec73455116","order_by":7,"name":"Jin Cheng","email":"","orcid":"","institution":"Pittsburgh Veteran Affairs Medical Center","correspondingAuthor":false,"prefix":"","firstName":"Jin","middleName":"","lastName":"Cheng","suffix":""},{"id":518470912,"identity":"851030de-c12f-4f55-926e-e7a07e740e4c","order_by":8,"name":"Antoine Douaihy","email":"","orcid":"","institution":"University of Pittsburgh","correspondingAuthor":false,"prefix":"","firstName":"Antoine","middleName":"","lastName":"Douaihy","suffix":""},{"id":518470913,"identity":"6ad89854-622e-4409-8d2b-1ae2617661ed","order_by":9,"name":"Ramon Bataller","email":"","orcid":"","institution":"University of Pittsburgh","correspondingAuthor":false,"prefix":"","firstName":"Ramon","middleName":"","lastName":"Bataller","suffix":""},{"id":518470914,"identity":"6b874dde-2c96-46d1-b9a6-f7248c4fc93e","order_by":10,"name":"Claes Wahlestedt","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAABCklEQVRIiWNgGAWjYHACNoYHYDqBEUgzgxFDAgMDYwM+LUAFEgwMycwGJGthk4CohwCcWvhnJD97kFBRV8fPnn+s6kaFNYNuO/PTDQ8YbGQ3HMCuReJGmrlBwpnDEpI9j9lu55xJZzA7zGZ2I4EhzRiXFgPpBDOJxLYDEgY3ktlu57YdBmphAGk5nIhbS/o3icR/dRL2QC3Fuf9AWti/AbX8x6MlB2hLA7OEgUQyG3NuA0gLD8iWAzi1SNx/UyaRcOyw5Iwzj42lc46l8wC1lN1IMEg2nolDC3/P8W0SH2rq+PnbEx9+zqmxljM7f3zbzR8VdrJ9OLRgAB6og4lUPgpGwSgYBaMAKwAAhaJfDhgZRA4AAAAASUVORK5CYII=","orcid":"","institution":"University of Miami","correspondingAuthor":true,"prefix":"","firstName":"Claes","middleName":"","lastName":"Wahlestedt","suffix":""}],"badges":[],"createdAt":"2025-08-15 10:38:13","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-7380649/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-7380649/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":92233447,"identity":"1f1ba12e-00ed-4285-98d8-483ad3780cf8","added_by":"auto","created_at":"2025-09-26 06:55:55","extension":"docx","order_by":0,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":30235960,"visible":true,"origin":"","legend":"","description":"","filename":"Manuscript.docx","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/db8cbfc7f24f553438a0f852.docx"},{"id":92233442,"identity":"04fec1aa-af31-4220-9012-b026ae3f3974","added_by":"auto","created_at":"2025-09-26 06:55:55","extension":"json","order_by":1,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":11766,"visible":true,"origin":"","legend":"","description":"","filename":"ae2dc701288242edb95df70bd5577beb.json","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/4751d595b29d40cb800e2a4f.json"},{"id":92234427,"identity":"5e40da2c-791e-41fc-b076-c743942d9f30","added_by":"auto","created_at":"2025-09-26 07:03:56","extension":"docx","order_by":2,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":13531472,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementaryFiguresS1S8.docx","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/79eeb61b61ad42f35afbd32f.docx"},{"id":92235291,"identity":"733f2077-42fc-48ec-8e9a-d029683c568c","added_by":"auto","created_at":"2025-09-26 07:11:55","extension":"xlsx","order_by":3,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":10827,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementaryTableS1.OverlappingDownregulatedTranscriptomeineASHandsAH.xlsx","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/d0aebcfad88bf5c6a13ae3fb.xlsx"},{"id":92235294,"identity":"9c501019-009e-474a-ae0e-d682869068a9","added_by":"auto","created_at":"2025-09-26 07:11:56","extension":"xlsx","order_by":4,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":10830,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementaryTableS2.OverlappingDownregulatedTranscriptomeineASHandexAH.xlsx","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/70ad182ee345b6e3b1df9843.xlsx"},{"id":92233453,"identity":"c2f2f84c-a31b-40b8-8c60-b9deb89829fe","added_by":"auto","created_at":"2025-09-26 06:55:56","extension":"xlsx","order_by":5,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":75789,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementaryTableS3.ConsistentTranscriptomicChanges.xlsx","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/673c93b514ef32fa2bf3faf6.xlsx"},{"id":92235295,"identity":"e30e469a-4a22-446b-aa8d-c684cd6e9475","added_by":"auto","created_at":"2025-09-26 07:11:57","extension":"xlsx","order_by":6,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":10634,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementaryTableS4.ListofSpliceosomalGenes.xlsx","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/1c7bdc0d5e2684d98c8ae7b4.xlsx"},{"id":92233484,"identity":"a6631f2c-e9b9-4f0b-bff8-fe7885180288","added_by":"auto","created_at":"2025-09-26 06:55:57","extension":"xlsx","order_by":7,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":10688,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementaryTableS5.GenesfromDifferentChromosomes.xlsx","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/f16b818767425df3fc240667.xlsx"},{"id":92234424,"identity":"ffd6bb15-25c4-4d72-8591-8446daea549d","added_by":"auto","created_at":"2025-09-26 07:03:56","extension":"xlsx","order_by":8,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":10639,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementaryTableS6.GenesInvolvedinSpermatogenesis.xlsx","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/8c89e14679dbe464ba02592a.xlsx"},{"id":92234434,"identity":"6e14d7ab-579c-4cde-a529-1720b8283e9b","added_by":"auto","created_at":"2025-09-26 07:03:57","extension":"xlsx","order_by":9,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":10621,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementaryTableS7.GenesInvolvedinGluconeogenesis.xlsx","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/3e920fcec525f224c560756b.xlsx"},{"id":92233481,"identity":"867f01da-1f65-442f-a820-e07b80322ce2","added_by":"auto","created_at":"2025-09-26 06:55:57","extension":"xlsx","order_by":10,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":10973,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementaryTableS8.snRNAsprimers.xlsx","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/549be0f7e72be3f1f1517e75.xlsx"},{"id":92233479,"identity":"c80cb6d4-d3ff-4bc4-9384-d3957f121faf","added_by":"auto","created_at":"2025-09-26 06:55:57","extension":"xml","order_by":11,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":217651,"visible":true,"origin":"","legend":"","description":"","filename":"ae2dc701288242edb95df70bd5577beb1enriched.xml","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/44ba0cafa868da5cab6ccd68.xml"},{"id":92234429,"identity":"85dedb8c-81a7-42e0-8c00-4b0c407b67cc","added_by":"auto","created_at":"2025-09-26 07:03:56","extension":"jpeg","order_by":12,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":301903,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage1.jpeg","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/0a97af56e316ea6281f8ce50.jpeg"},{"id":92233487,"identity":"02bebd12-15a6-4c18-a1ad-3fc749229788","added_by":"auto","created_at":"2025-09-26 06:55:57","extension":"jpeg","order_by":13,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":1074,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage10.jpeg","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/08e6c171926f0d73b6845b07.jpeg"},{"id":92233464,"identity":"0890fba0-f971-484d-a2fc-a4fc8cf32963","added_by":"auto","created_at":"2025-09-26 06:55:56","extension":"jpeg","order_by":14,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":629361,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage2.jpeg","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/bcacfb73a527cb6ce27db3bb.jpeg"},{"id":92234428,"identity":"1a704d1b-3d88-4ee1-bf4f-9428dffd2411","added_by":"auto","created_at":"2025-09-26 07:03:56","extension":"jpeg","order_by":15,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":688631,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage3.jpeg","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/8d912937d7f27cb4202a8d8e.jpeg"},{"id":92233483,"identity":"3f17bcb4-2b4b-4eb2-b733-522308e1d32c","added_by":"auto","created_at":"2025-09-26 06:55:57","extension":"jpeg","order_by":16,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":338290,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage4.jpeg","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/1334d92bb77f559884ce6b4d.jpeg"},{"id":92234426,"identity":"9a443956-2a0f-4b9e-b46f-18eed60d5b09","added_by":"auto","created_at":"2025-09-26 07:03:56","extension":"jpeg","order_by":17,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":331496,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage5.jpeg","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/20be7c344ae3bf311cd114c6.jpeg"},{"id":92233465,"identity":"d0a7ac00-24e7-463f-a7b5-81373a7b1b5d","added_by":"auto","created_at":"2025-09-26 06:55:56","extension":"jpeg","order_by":18,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":337627,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage6.jpeg","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/324d558ebf0c8fb44be47ff1.jpeg"},{"id":92234430,"identity":"6fd5fe49-6f2d-4b17-9f6a-a4f0260ea690","added_by":"auto","created_at":"2025-09-26 07:03:56","extension":"jpeg","order_by":19,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":381530,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage7.jpeg","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/b2c254f3d92fa4a808a70dd3.jpeg"},{"id":92234435,"identity":"fb6db397-090c-4f09-9aaa-a509f35f3d0b","added_by":"auto","created_at":"2025-09-26 07:03:58","extension":"jpeg","order_by":20,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":259062,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage8.jpeg","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/ed1f407533e83f81f9b33847.jpeg"},{"id":92233457,"identity":"76b6f7c3-e8cb-40d6-bbe5-e5f0c36093d8","added_by":"auto","created_at":"2025-09-26 06:55:56","extension":"jpeg","order_by":21,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":766888,"visible":true,"origin":"","legend":"","description":"","filename":"floatimage9.jpeg","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/e6929c9ca4517320e1ea7bd2.jpeg"},{"id":92233478,"identity":"376addfb-13f8-41ee-a648-7bac2870d7be","added_by":"auto","created_at":"2025-09-26 06:55:57","extension":"png","order_by":22,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":49770,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage1.png","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/77f17543c6d47879ce5597f4.png"},{"id":92233489,"identity":"ba7ef307-1301-425d-bcb0-27de2ff89dbc","added_by":"auto","created_at":"2025-09-26 06:55:58","extension":"png","order_by":23,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":935,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage10.png","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/45d5dbd28bce34b88899162b.png"},{"id":92233466,"identity":"d8e4806e-9acd-4feb-9ddc-e56d1faa635b","added_by":"auto","created_at":"2025-09-26 06:55:56","extension":"png","order_by":24,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":157815,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage2.png","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/d2ddb16cecdde306ca2a2c14.png"},{"id":92233474,"identity":"5c97f62c-ae26-45e7-b9be-380c3d2f79ce","added_by":"auto","created_at":"2025-09-26 06:55:57","extension":"png","order_by":25,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":85718,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage3.png","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/017da16a24f8b50baf743374.png"},{"id":92233469,"identity":"803f2083-6f52-40b4-b67a-c79f3ad25c24","added_by":"auto","created_at":"2025-09-26 06:55:56","extension":"png","order_by":26,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":53273,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage4.png","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/5acb2cda205ad63914a55545.png"},{"id":92233488,"identity":"d0af0e23-0a8c-453f-8c8a-6fc894c0d7b9","added_by":"auto","created_at":"2025-09-26 06:55:57","extension":"png","order_by":27,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":47074,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage5.png","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/6c579d33eefc6505878fb41b.png"},{"id":92233461,"identity":"c385fc7d-08da-4fe5-93ae-a1f62daa1eb1","added_by":"auto","created_at":"2025-09-26 06:55:56","extension":"png","order_by":28,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":38500,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage6.png","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/643eae1fca52e713f03928bd.png"},{"id":92234432,"identity":"bc3c368a-eef8-4931-9bed-73dc555207c8","added_by":"auto","created_at":"2025-09-26 07:03:57","extension":"png","order_by":29,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":54397,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage7.png","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/be3d5f6a1d2d23e70f316a51.png"},{"id":92233485,"identity":"729f0d70-e4a2-43c0-93e9-bd25530b2923","added_by":"auto","created_at":"2025-09-26 06:55:57","extension":"png","order_by":30,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":52117,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage8.png","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/935e1b34c0a4f166d7be98fe.png"},{"id":92233491,"identity":"ea8c0d31-ea40-405e-8ebb-aa8cac84f041","added_by":"auto","created_at":"2025-09-26 06:55:58","extension":"png","order_by":31,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":143480,"visible":true,"origin":"","legend":"","description":"","filename":"Onlinefloatimage9.png","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/49d85ef7c82f4d1a40eb5072.png"},{"id":92233477,"identity":"99e8358f-dd9b-4b05-8f5f-e9c92decee2e","added_by":"auto","created_at":"2025-09-26 06:55:57","extension":"xml","order_by":32,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":213734,"visible":true,"origin":"","legend":"","description":"","filename":"ae2dc701288242edb95df70bd5577beb1structuring.xml","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/3231b65fde8622aff5dd7914.xml"},{"id":92233451,"identity":"799ff35c-aece-4539-9296-eda4618c2953","added_by":"auto","created_at":"2025-09-26 06:55:56","extension":"html","order_by":33,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":238637,"visible":true,"origin":"","legend":"","description":"","filename":"earlyproof.html","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/f76766391e9388faaf013610.html"},{"id":92233454,"identity":"2d30b15c-6c4e-47d6-ac67-edf3af97dcf4","added_by":"auto","created_at":"2025-09-26 06:55:56","extension":"jpg","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":33687,"visible":true,"origin":"","legend":"\u003cp\u003eDifferentially expressed genes in the liver from patients with alcohol-related hepatic diseases. eASH – early alcoholic steatohepatitis, nsAH – non-severe alcoholic hepatitis, sAH – severe alcoholic hepatitis, exAH – explants from patients who underwent hepatic transplantation due to liver failure.\u003c/p\u003e","description":"","filename":"Picture1.jpg","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/3ca647ac28da0bfd2113a2a3.jpg"},{"id":92233458,"identity":"61805b24-1e46-40d8-a0ac-d7cca6284626","added_by":"auto","created_at":"2025-09-26 06:55:56","extension":"jpg","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":53284,"visible":true,"origin":"","legend":"\u003cp\u003eGenes affected in all groups. Top portion of the plot represents 440 transcripts upregulated across all groups, bottom part – 825 downregulated transcripts. X axis signifies chromosomes, y axis corresponds to Zcuts values for each gene that match to four groups. eASH – early alcoholic steatohepatitis, nsAH – non-severe alcoholic hepatitis, sAH – severe alcoholic hepatitis, exAH – explants from patients who underwent hepatic transplantation due to liver failure.\u003c/p\u003e","description":"","filename":"Picture2.jpg","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/b9dba398a7c1b0873aecfb0c.jpg"},{"id":92234423,"identity":"5465d76b-3b3a-4caa-babb-e48b639a6efb","added_by":"auto","created_at":"2025-09-26 07:03:56","extension":"jpg","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":77990,"visible":true,"origin":"","legend":"\u003cp\u003eMissplicing patterns in the liver in patients across alcohol-related liver disease spectrum. 5’-SS – alternative 5’ splice site, IR – intron retention, 3’-SS – alternative 3’ splice site, ES – exon skipping, MEE – mutually exclusive exons; eASH – early alcoholic steatohepatitis, nsAH – non-severe alcoholic hepatitis, sAH – severe alcoholic hepatitis, exAH – explants from patients who underwent hepatic transplantation due to liver failure. C-S – chi-square test.\u003c/p\u003e","description":"","filename":"Picture3.jpg","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/3f6b63a5b88874747daffebf.jpg"},{"id":92234420,"identity":"2ce820d0-4758-4e38-89ad-d252840354fc","added_by":"auto","created_at":"2025-09-26 07:03:55","extension":"jpg","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":35929,"visible":true,"origin":"","legend":"\u003cp\u003eExon expression in the liver of patients with alcohol-related hepatic diseases. eASH – early alcoholic steatohepatitis, nsAH – non-severe alcoholic hepatitis, sAH – severe alcoholic hepatitis, exAH – explants from patients who underwent hepatic transplantation due to liver failure. Difference in proportion of affected exons between groups was calculated using chi-square test.\u003c/p\u003e","description":"","filename":"Picture4.jpg","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/5bf8bd44ee918b4e2d494ec0.jpg"},{"id":92234421,"identity":"017a0219-cce8-4823-a5fa-6eeefcea7bdd","added_by":"auto","created_at":"2025-09-26 07:03:55","extension":"jpg","order_by":5,"title":"Figure 5","display":"","copyAsset":false,"role":"figure","size":49683,"visible":true,"origin":"","legend":"\u003cp\u003eExpression of snRNAs in the liver of rats exposed to alcohol vapor. n.d. – not detected. * – P \u0026lt; 0.05.\u003c/p\u003e","description":"","filename":"Picture5.jpg","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/83cb8260ec7834403ead2848.jpg"},{"id":92233476,"identity":"58b0a6bf-909f-4b47-8797-63d7647625fa","added_by":"auto","created_at":"2025-09-26 06:55:57","extension":"jpg","order_by":6,"title":"Figure 6","display":"","copyAsset":false,"role":"figure","size":53238,"visible":true,"origin":"","legend":"\u003cp\u003eExpression of cancer-related splicing-factors in the liver of rats exposed to alcohol vapor and in the liver of humans with various stages of alcohol-induced hepatic damage. eASH – early alcoholic steatohepatitis, nsAH – non-severe alcoholic hepatitis, sAH – severe alcoholic hepatitis, exAH – explants from patients who underwent hepatic transplantation due to liver failure.\u003c/p\u003e","description":"","filename":"Picture6.jpg","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/d065a42b325624c098ff77f3.jpg"},{"id":92233456,"identity":"434f28d5-44a8-43cc-9981-eb27676d2f80","added_by":"auto","created_at":"2025-09-26 06:55:56","extension":"jpg","order_by":7,"title":"Figure 7","display":"","copyAsset":false,"role":"figure","size":38539,"visible":true,"origin":"","legend":"\u003cp\u003eExpression of 127 splicing factors in the liver of patients with various stages of alcohol-induced hepatic damage. eASH – early alcoholic steatohepatitis, nsAH – non-severe alcoholic hepatitis, sAH – severe alcoholic hepatitis, exAH – explants from patients who underwent hepatic transplantation due to liver failure.\u003c/p\u003e","description":"","filename":"Picture7.jpg","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/e2507245b6b6e71f1983b7c1.jpg"},{"id":92233470,"identity":"1681d80c-2b72-4931-91de-a36698e14acb","added_by":"auto","created_at":"2025-09-26 06:55:56","extension":"jpg","order_by":8,"title":"Figure 8","display":"","copyAsset":false,"role":"figure","size":56679,"visible":true,"origin":"","legend":"\u003cp\u003eAlcohol use disorder results in missplicing and aberrant gene expression in the liver affecting genes involved in the development of hepatocellular carcinoma. Potential mechanism of missplicing involved suppression of snRNAs and deregulation of lncRNAs.\u003c/p\u003e","description":"","filename":"Picture8.jpg","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/ad261a80ca12c4b0d2425161.jpg"},{"id":92236325,"identity":"d601524b-c0cf-4b1c-94fa-92fe469e341f","added_by":"auto","created_at":"2025-09-26 07:27:56","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1775416,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/dfdd5a23-2e53-4726-858f-0b846ca25bb2.pdf"},{"id":92234416,"identity":"9f3ac078-21b4-454c-a519-747ca25afa06","added_by":"auto","created_at":"2025-09-26 07:03:55","extension":"xlsx","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":10830,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementaryTableS2.OverlappingDownregulatedTranscriptomeineASHandexAH.xlsx","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/bdfc33c007020db356bc565c.xlsx"},{"id":92233440,"identity":"b3ae126b-0679-4735-a637-cdd68afa57c3","added_by":"auto","created_at":"2025-09-26 06:55:55","extension":"xlsx","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":10634,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementaryTableS4.ListofSpliceosomalGenes.xlsx","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/5b59669271e717d53e7311a8.xlsx"},{"id":92233455,"identity":"11809d06-e66b-44ac-871a-fd9f1f93c680","added_by":"auto","created_at":"2025-09-26 06:55:56","extension":"xlsx","order_by":2,"title":"","display":"","copyAsset":false,"role":"supplement","size":10639,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementaryTableS6.GenesInvolvedinSpermatogenesis.xlsx","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/83b2bd161a38f83ab16e77f1.xlsx"},{"id":92235478,"identity":"88dd7ec7-92cd-4941-a481-405fc803a6ee","added_by":"auto","created_at":"2025-09-26 07:19:55","extension":"xlsx","order_by":3,"title":"","display":"","copyAsset":false,"role":"supplement","size":10827,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementaryTableS1.OverlappingDownregulatedTranscriptomeineASHandsAH.xlsx","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/eb5c9f4b678df90f8cc98248.xlsx"},{"id":92234417,"identity":"3ca6bd13-f360-42b0-9b45-0c269bce92c5","added_by":"auto","created_at":"2025-09-26 07:03:55","extension":"xlsx","order_by":4,"title":"","display":"","copyAsset":false,"role":"supplement","size":10688,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementaryTableS5.GenesfromDifferentChromosomes.xlsx","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/73d98f1dcf70483966258f8d.xlsx"},{"id":92234425,"identity":"cfaed2d6-7949-4ec4-a3a4-955aaee5a5ca","added_by":"auto","created_at":"2025-09-26 07:03:56","extension":"xlsx","order_by":5,"title":"","display":"","copyAsset":false,"role":"supplement","size":10621,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementaryTableS7.GenesInvolvedinGluconeogenesis.xlsx","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/5d9c76029ab3ec5a73eb6d41.xlsx"},{"id":92233459,"identity":"c2f2e635-f391-4ba4-ad6b-328968e66df5","added_by":"auto","created_at":"2025-09-26 06:55:56","extension":"xlsx","order_by":6,"title":"","display":"","copyAsset":false,"role":"supplement","size":75789,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementaryTableS3.ConsistentTranscriptomicChanges.xlsx","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/601fc6721fdce87ea6ec3af0.xlsx"},{"id":92233443,"identity":"c2a5e644-583b-4e90-8046-84c26d7d1aef","added_by":"auto","created_at":"2025-09-26 06:55:55","extension":"xlsx","order_by":7,"title":"","display":"","copyAsset":false,"role":"supplement","size":10973,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementaryTableS8.snRNAsprimers.xlsx","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/309a9e2a97fc3d89b290572f.xlsx"},{"id":92233475,"identity":"566eea46-9b50-41f1-b967-52dcf2ccd316","added_by":"auto","created_at":"2025-09-26 06:55:57","extension":"docx","order_by":8,"title":"","display":"","copyAsset":false,"role":"supplement","size":13531472,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementaryFiguresS1S8.docx","url":"https://assets-eu.researchsquare.com/files/rs-7380649/v1/9085f79c702672ea08f53f29.docx"}],"financialInterests":"No competing interests reported.","formattedTitle":"Global Changes in Gene Expression and Splicing in Alcoholic Liver Disease","fulltext":[{"header":"Introduction","content":"\u003cp\u003eAlcohol use disorder (AUD) is a chronic condition characterized by a problematic pattern of alcohol use leading to clinically significant impairment. According to the World Health Organization, alcohol consumption accounts for 4.7% of all deaths worldwide \u003csup\u003e\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e\u003c/sup\u003e. In the United States, 14% of adults currently meet criteria of AUD, 29% \u0026ndash; met AUD criteria once during their lifetime \u003csup\u003e\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e\u003c/sup\u003e; in addition, prevalence of AUD is increasing \u003csup\u003e\u003cspan additionalcitationids=\"CR4\" citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e\u003c/sup\u003e. Annual cost of AUD and alcohol-related disorders is ~\u003cspan\u003e$\u003c/span\u003e250\u0026nbsp;billion \u003csup\u003e\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e,\u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e\u003c/sup\u003e. Due to high prevalence and lack of efficient treatment modalities, AUD causes significant socioeconomic burden. Apart from direct physiological and psychological problems associated with AUD, the burden is connected to alcohol-related medical conditions. One of the major and most common co-morbidities is alcoholic liver disease (ALD) which, in turn, is associated with hepatocellular carcinoma (HCC).\u003c/p\u003e\u003cp\u003eALD is a broad diagnosis which encompasses the continuum of alcoholic steatosis, alcoholic steatohepatitis (eASH), alcoholic hepatitis (AH), and, finally, cirrhosis \u003csup\u003e\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e\u003c/sup\u003e. Most patients develop HCC at the stage of cirrhosis, but 11\u0026ndash;31% of HCC patients present with HCC in the absence of cirrhotic changes \u003csup\u003e\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e,\u003cspan citationid=\"CR10\" class=\"CitationRef\"\u003e10\u003c/span\u003e\u003c/sup\u003e. HCC is the most common liver cancer and one of the most aggressive cancers. Worldwide, ~\u0026thinsp;850,000 people are diagnosed with HCC every year \u003csup\u003e\u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e,\u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e\u003c/sup\u003e. Therapeutic approaches for advanced stage HCC are very few. Modest improvement was observed after administration of multiple tyrosine kinase inhibitors sorafenib and lenvatinib \u003csup\u003e\u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e13\u003c/span\u003e,\u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e\u003c/sup\u003e and immunotherapies \u003csup\u003e\u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e,\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e\u003c/sup\u003e, but prognosis for patients with advanced HCC is still poor, with an overall survival of around 1 year with the best treatment implemented \u003csup\u003e\u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e17\u003c/span\u003e\u003c/sup\u003e. HCC remains the second leading cause of cancer-related death in the world claiming\u0026thinsp;~\u0026thinsp;700,000 deaths annually \u003csup\u003e\u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e18\u003c/span\u003e,\u003cspan citationid=\"CR19\" class=\"CitationRef\"\u003e19\u003c/span\u003e\u003c/sup\u003e. The link between AUD and HCC is well established in case-control studies \u003csup\u003e\u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e\u003c/sup\u003e and meta-analyses \u003csup\u003e\u003cspan citationid=\"CR21\" class=\"CitationRef\"\u003e21\u003c/span\u003e\u003c/sup\u003e, and alcohol-related HCC was shown to have significantly worse prognosis than HCC related to viral hepatitides \u003csup\u003e\u003cspan citationid=\"CR22\" class=\"CitationRef\"\u003e22\u003c/span\u003e,\u003cspan citationid=\"CR23\" class=\"CitationRef\"\u003e23\u003c/span\u003e\u003c/sup\u003e.\u003c/p\u003e\u003cp\u003eThat treatment of HCC is often insufficient may result from an incomplete insight on how HCC arises and progresses. HCC represents a heterogeneous group of tumors with molecular signatures closely connected to risk factors \u003csup\u003e\u003cspan citationid=\"CR24\" class=\"CitationRef\"\u003e24\u003c/span\u003e\u003c/sup\u003e. It is possible that AUD-related HCC develops via distinct molecular mechanism \u003csup\u003e\u003cspan citationid=\"CR25\" class=\"CitationRef\"\u003e25\u003c/span\u003e\u003c/sup\u003e and that some alcohol-induced molecular changes causing or predisposing to HCC occur at the stage of AH \u003csup\u003e\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e,\u003cspan citationid=\"CR10\" class=\"CitationRef\"\u003e10\u003c/span\u003e\u003c/sup\u003e. Recent data indicate that potential mechanistic overlap between AUD and HCC may involve impaired splicing. Splicing is a nuclear process of removing introns from pre-mRNA after which mature mRNA is produced and exported into the cytoplasm for translation. Splicing is mediated by a major spliceosome, a nuclear machinery which consists of 5 small nuclear RNAs (snRNA1 (snU1), snU2, snU4, snU5, and snU6) and dozens of splicing factors \u003csup\u003e\u003cspan citationid=\"CR26\" class=\"CitationRef\"\u003e26\u003c/span\u003e\u003c/sup\u003e. Among snRNAs, snU1 and snU2 are considered to be critical. snU1 recognizes 5\u0026rsquo; splice site forming the early splicing complex while snU2 recognizes 3\u0026rsquo; splice site. Among chief splicing factors with an established link to cancers are SF1, SF3B1, SRSF1, SRSF2, SRSF3, ZRSR2, and U2AF1 \u003csup\u003e27\u0026ndash;29\u003c/sup\u003e. SF1 is responsible for the recognition of the branch point \u003csup\u003e\u003cspan citationid=\"CR30\" class=\"CitationRef\"\u003e30\u003c/span\u003e\u003c/sup\u003e. When branch point pairs with snU2, SF1 is displaced and branching site is contacted by SF3B1, a core component of the U2 small nuclear ribonucleoprotein (U2 snRNP), which ensures stabilization of U2 snRNP on pre-mRNA \u003csup\u003e\u003cspan citationid=\"CR26\" class=\"CitationRef\"\u003e26\u003c/span\u003e\u003c/sup\u003e. SRSF1, SRSF2, and SRSF3 belong to the family of serine-arginine (SR) splicing factors which contain a protein domain composed of SR repeats; SRSF proteins are recruited with snU1 by RNA polymerase II and function mainly to couple splicing with transcription \u003csup\u003e\u003cspan citationid=\"CR31\" class=\"CitationRef\"\u003e31\u003c/span\u003e\u003c/sup\u003e. ZRSR2 and U2AF1 are required for the recognition of 3\u0026rsquo; splice site \u003csup\u003e\u003cspan citationid=\"CR32\" class=\"CitationRef\"\u003e32\u003c/span\u003e,\u003cspan citationid=\"CR33\" class=\"CitationRef\"\u003e33\u003c/span\u003e\u003c/sup\u003e. Regulation of splicing is poorly understood, but there is some evidence indicating that long non-coding RNAs (lncRNAs) might be involved. LncRNAs are non-coding RNA molecules\u0026thinsp;\u0026gt;\u0026thinsp;200 nucleotides in length which are capable of interacting with both short RNAs and proteins \u003csup\u003e\u003cspan citationid=\"CR34\" class=\"CitationRef\"\u003e34\u003c/span\u003e\u003c/sup\u003e and thus may serve as a \u0026ldquo;screwdriver\u0026rdquo; for spliceosome. It was shown that lncRNA Gomafu (also known as myocardial infarction-associated transcript (MIAT)) affects formation of spliceosomes and inhibits splicing factor SF1 \u003csup\u003e35\u003c/sup\u003e. Another lncRNA, MALAT1, interacts with SR splicing factors causing deregulation of splicing in a genome-wide fashion \u003csup\u003e\u003cspan citationid=\"CR36\" class=\"CitationRef\"\u003e36\u003c/span\u003e,\u003cspan citationid=\"CR37\" class=\"CitationRef\"\u003e37\u003c/span\u003e\u003c/sup\u003e.\u003c/p\u003e\u003cp\u003eData on splicing in AUD are relatively scanty. Alcohol intake was shown to be associated with a missplicing of specific transcripts such as mRNA for AMPA receptors \u003csup\u003e\u003cspan citationid=\"CR38\" class=\"CitationRef\"\u003e38\u003c/span\u003e\u003c/sup\u003e and GABA-B receptors \u003csup\u003e\u003cspan citationid=\"CR39\" class=\"CitationRef\"\u003e39\u003c/span\u003e\u003c/sup\u003e. Disruption of splicing on a broader scale was observed in the brain cortex of human fetuses exposed to alcohol \u003csup\u003e\u003cspan citationid=\"CR40\" class=\"CitationRef\"\u003e40\u003c/span\u003e\u003c/sup\u003e. In our previous work, we observed AUD-induced genome-wide missplicing in different brain regions \u003csup\u003e\u003cspan citationid=\"CR41\" class=\"CitationRef\"\u003e41\u003c/span\u003e\u003c/sup\u003e. In HCC, splicing is studied more extensively. Analysis of HCC transcriptome identified\u0026thinsp;\u0026gt;\u0026thinsp;2,000 genes with altered splicing patterns which were distinct in HBV-induced, HCV-induced, and non-viral HCC \u003csup\u003e\u003cspan citationid=\"CR42\" class=\"CitationRef\"\u003e42\u003c/span\u003e\u003c/sup\u003e. It was also shown that HCC was accompanied by 34,163 alternative splicing events in 8,985 genes, and some missplicing patterns were associated with overall survival \u003csup\u003e\u003cspan citationid=\"CR43\" class=\"CitationRef\"\u003e43\u003c/span\u003e\u003c/sup\u003e. However, the extent and mechanisms of missplicing in AUD and ALD-related HCC remain unknown.\u003c/p\u003e\u003cp\u003eThe goal of the current study was to determine if AUD may relate to HCC via missplicing in the liver. We found that chronic alcohol use causes genome-wide changes in hepatic gene expression and splicing. Mechanistically, it appears to be mediated by defects in the spliceosomal machinery as well as by an aberrant expression of lncRNAs related to splicing. Numerous oncogenes and tumor suppressors were among affected genes in all alcohol-related hepatic conditions suggesting a novel mechanism contributing to the development of AUD-related HCC.\u003c/p\u003e"},{"header":"Results","content":"\u003cdiv id=\"Sec4\" class=\"Section2\"\u003e\u003ch2\u003eSubjects\u003c/h2\u003e\u003cp\u003eDemographics and pertinent clinical data are listed in Table\u0026nbsp;1. Patients with alcohol-induced liver damage did not differ in age or gender. Child-Pugh, MELD, and ABIC scores all increased from nsAH to sAH, but there was no difference between sAH and exAH groups. Frequency of symptoms of hepatic decompensation such as ascites, hepatic encephalopathy, upper gastrointestinal bleeding, acute kidney injury, and infections tended to increase from nsAH to sAH. White blood cell counts increased and hemoglobin and platelet counts decreased throughout eASH-nsAH-sAH-exAH continuum. As expected, levels of bilirubin alkaline phosphatase were higher in patients with alcohol-induced liver damage. Liver diseases were also associated with low albumin, hyponatremia, and increased prothrombin time (expressed as International Normalized Ratio (INR)). Of note, creatinine levels were normal across phenotypes, ruling out the presence of hepatorenal syndrome.\u003c/p\u003e\u003c/div\u003e\n\u003ch3\u003eEffect of alcohol on hepatic transcriptome\u003c/h3\u003e\n\u003cp\u003eWe have previously shown that there are extensive transcriptomic changes imparted by some stages of ALD \u003csup\u003e\u003cspan citationid=\"CR44\" class=\"CitationRef\"\u003e44\u003c/span\u003e\u003c/sup\u003e, but the assessment of ALD-related transcriptomic reprogramming encompassed only protein-coding genes and did not include the analysis of splice variants. We therefore decided to interrogate RNA sequences datasets in order to evaluate the extent of differential expression and missplicing of both coding and non-coding features. The analysis of expression of 57,820 features confirmed that alcohol caused genome-wide changes in hepatic transcriptome, with a number of differentially expressed genes positively correlating with a disease severity. In eASH, 4,928 were altered (8.5%), in nsAH \u0026ndash; 9,075 (15.7%), in sAH \u0026ndash; 14,100 (24.4%), and in exAH \u0026ndash; 14,292 (24.7%) (Fig.\u0026nbsp;\u003cspan refid=\"Fig1\" class=\"InternalRef\"\u003e1\u003c/span\u003e). When considering the RNA biotypes, the composition of altered transcriptomes was relatively similar in all alcohol-related condition, with a majority of affected genes (60\u0026ndash;70%) being represented by protein-coding genes (Supplementary Fig. \u003cspan refid=\"MOESM1\" class=\"InternalRef\"\u003eS1\u003c/span\u003e). Altered transcriptome profiles demonstrated a considerable overlap (data not shown) suggesting that alcohol-related transcriptomic changes are persistent, cumulative along the progression of ALD, and unlikely to be random. To address functional implications of altered transcriptomes, we analyzed transcriptomic overlaps between eASH and later stages of alcohol-induced hepatic damage such as sAH and exAH. Gene Ontology analysis of overlapping suppressed genes revealed that downregulated features are mainly involved in oncogenesis: affected pathways included DNA replication, DNA damage response, cell cycle, and regulation of mitosis (Supplementary Tables\u0026nbsp;1 and 2).\u003c/p\u003e\u003cp\u003eNext, we asked if there are transcriptional changes that persist across all stages of alcohol-induced hepatic damage and assessed determined genes up- or downregulated in all four groups. In total, expression of 1,265 were either increased or decreased throughout eASH-nsAH-sAH-exAH continuum (Fig.\u0026nbsp;\u003cspan refid=\"Fig2\" class=\"InternalRef\"\u003e2\u003c/span\u003e). 440 genes were upregulated in all groups, 825 \u0026ndash; downregulated in all groups (Supplementary Table\u0026nbsp;3) indicating the broad character of alcohol-induced transcriptomic changes across all conditions.\u003c/p\u003e\n\u003ch3\u003eEffect of alcohol on splicing\u003c/h3\u003e\n\u003cp\u003eEffect of alcohol on splicing in the liver has not been well studied, and extent and characteristics of hepatic missplicing in ALD are not known. We employed MATS program \u003csup\u003e\u003cspan citationid=\"CR45\" class=\"CitationRef\"\u003e45\u003c/span\u003e\u003c/sup\u003e to unbiasedly detect such missplicing events as 5\u0026rsquo; alternative splice sites (5\u0026rsquo;-SS), 3\u0026rsquo; alternative splice sites (3\u0026rsquo;-SS), intron retention (IR), exon skipping (ES) and mutually exclusive exons (MEE). In all alcohol-related conditions, ES and MEE were the most common events (Fig.\u0026nbsp;\u003cspan refid=\"Fig3\" class=\"InternalRef\"\u003e3\u003c/span\u003e). Number of ES was relatively similar across all conditions: 1,542, 1,668, 1660, and 1,623 in eASH, nsAH, sAH, and exAH, respectively. MEE, on the other hand, differed significantly in various conditions. The number of MEEs was 1,186 in eASH, rose to 3,119 in nsAH, and then subsided to 2,668 and 2,094 in sAH and exAH, respectively. Frequency of 5\u0026rsquo;-SS, 3\u0026rsquo;-SS, and IR was much lower in comparison to ES and MEE, and the dynamics of their quantitative changes was similar, being observed at the stage of eASH, occurring most frequently at the stage of nsAH, and returning to eASH levels at sAH and exAH stages.\u003c/p\u003e\n\u003ch3\u003eEffect of alcohol on exon expression\u003c/h3\u003e\n\u003cp\u003eBased on the high number of alcohol-induced missplicing events across all conditions, we hypothesized that the variety of differentially expressed transcripts in the liver may be larger than detected on standard differential expression analysis (Fig.\u0026nbsp;\u003cspan refid=\"Fig1\" class=\"InternalRef\"\u003e1\u003c/span\u003e). We reasoned that missplicing may cause changes in the expression and presence of specific exons without altering a total expression counts of a specific gene, as quantified by conventional pipelines. In such a case, the quantification of individual exons might therefore provide a more accurate insight into alcohol-induced changes in transcriptional landscape and give clues of potentially relevant changes in mRNA and amino acid sequence of key molecular drivers. We used DEXSeq R package to perform exon expression analysis. The interrogation of 588,998 exons showed that alcohol causes genome-wide changes in exon expression, with number of affected exons positively correlating with the stage of disease. Thus, 46,045 (7.8%) exons were altered in eASH, 126,145 (21.4%) \u0026ndash; in nsAH, 152,335 (25.9%) \u0026ndash; in sAH, and 123,282 (20.9%) \u0026ndash; in exAH (Fig.\u0026nbsp;\u003cspan refid=\"Fig4\" class=\"InternalRef\"\u003e4\u003c/span\u003e).\u003c/p\u003e\n\u003ch3\u003eEffect of alcohol on snRNAs\u003c/h3\u003e\n\u003cp\u003eWe next asked which mechanism may be responsible for such broad alcohol-induced alterations of splicing landscape. Splicing is governed mainly by a major spliceosome, a nuclear machinery which consists of 5 small nuclear RNAs (snRNA) and multiple proteins, known as splicing factors. The snRNAs are involved in the recognition of introns, formation of splicing complexes, and splicing reactions \u003csup\u003e\u003cspan citationid=\"CR46\" class=\"CitationRef\"\u003e46\u003c/span\u003e,\u003cspan citationid=\"CR47\" class=\"CitationRef\"\u003e47\u003c/span\u003e\u003c/sup\u003e. The major spliceosome includes 5 snRNAs: snU1, snU2, snU4, snU5, and snU6. Although data on AUD-induced changes in splicing began to accumulate \u003csup\u003e\u003cspan citationid=\"CR40\" class=\"CitationRef\"\u003e40\u003c/span\u003e,\u003cspan citationid=\"CR41\" class=\"CitationRef\"\u003e41\u003c/span\u003e,\u003cspan citationid=\"CR48\" class=\"CitationRef\"\u003e48\u003c/span\u003e\u003c/sup\u003e, the impact of alcohol on snRNA has not been explored. In most publicly available RNA sequencing datasets in alcohol-related disease studies, snRNAs are not well represented. Only in one of them \u003csup\u003e\u003cspan citationid=\"CR49\" class=\"CitationRef\"\u003e49\u003c/span\u003e\u003c/sup\u003e did we find robust expression values for most snRNAs; this study showed that treatment of primary hepatocytes with alcohol resulted in decreased expression of snU1 and snU4. That snRNAomes from most public RNA sequencing sources (such as NCBI or TCGA) are missing or unreliable may be due to the length of snRNAs: mature snRNAs are relatively short (\u0026lt;\u0026thinsp;200 nucleotides) and may not be detected by standard RNA sequencing protocols. Therefore, to investigate the direct effect of alcohol on the snRNAome \u003cem\u003ein vivo\u003c/em\u003e, we treated rats with alcohol vapor or left untreated for 7 weeks and measured the expression of snRNAs in the liver by real-time polymerase chain reaction (RT-PCR) using custom-made primers. Blood alcohol concentrations (BACs) levels were three times higher in exposed animals (Supplementary Fig.\u0026nbsp;2). Importantly, the expression of snU2 was 94% downregulated and snU1 was not changed; snU4 and snU6 were not detected (Fig.\u0026nbsp;\u003cspan refid=\"Fig5\" class=\"InternalRef\"\u003e5\u003c/span\u003e). We also studied the components of the minor spliceosome which is responsible for splicing of atypical snU12-type introns. This specific type of introns constitutes\u0026thinsp;~\u0026thinsp;0.5% of all introns in human genome, and their removal by minor spliceosome is known as non-canonical splicing \u003csup\u003e\u003cspan citationid=\"CR50\" class=\"CitationRef\"\u003e50\u003c/span\u003e,\u003cspan citationid=\"CR51\" class=\"CitationRef\"\u003e51\u003c/span\u003e\u003c/sup\u003e. In the minor spliceosome, the expression of snU6atac was completely abolished, and expression of snU11 was 92% reduced; snU12 was not detected (Fig.\u0026nbsp;\u003cspan refid=\"Fig5\" class=\"InternalRef\"\u003e5\u003c/span\u003e). Since in our model alcohol was delivered in the form of vapor, we reasoned that similar changes in snRNA expression may be also observed in the lung. We found that snU2 and snU11, but not snU6-atac, were significantly downregulated in the lung of rats subjected to alcohol vapor (Supplementary Fig.\u0026nbsp;3), although changes were less drastic than in the liver, indicating that the intensity or mode of alcohol-mediated alteration of the spliceosome could be organ-specific.\u003c/p\u003e\u003cdiv id=\"Sec9\" class=\"Section2\"\u003e\u003ch2\u003eEffect of alcohol on splicing factors\u003c/h2\u003e\u003cp\u003eNext, we addressed if alcohol affects expression of splicing factors. Among the main splicing factors with an established link to cancers are SF1, SF3B1, SRSF1, SRSF2, SRSF3, U2AF1, and ZRSR2 \u003csup\u003e27,28\u003c/sup\u003e. Analysis of their expression showed no differences between control rats and rats treated with alcohol both in the liver (Fig.\u0026nbsp;\u003cspan refid=\"Fig6\" class=\"InternalRef\"\u003e6\u003c/span\u003e) and the lungs (Supplementary Fig.\u0026nbsp;4). To determine if these factors were changed in patients with alcohol-related hepatic conditions, we retrieved and analyzed RNA sequencing data from patients with eASH, nsAH, sAH, and exAH and again found no difference between groups (Fig.\u0026nbsp;\u003cspan refid=\"Fig6\" class=\"InternalRef\"\u003e6\u003c/span\u003e). It appears that in contrast to snRNAs which are markedly decreased by alcohol, cancer-related splicing factors remain unaltered.\u003c/p\u003e\u003cp\u003eFurther, since we observed that many of these factors tended to decrease liver and lung of rats exposed to alcohol (Fig.\u0026nbsp;\u003cspan refid=\"Fig6\" class=\"InternalRef\"\u003e6\u003c/span\u003e and Supplementary Fig.\u0026nbsp;4, P\u0026thinsp;\u0026gt;\u0026thinsp;0.05), we reasoned that an effort to address the functional status of spliceosome by analyzing only 6 splicing factors may be inaccurate, as it may not fully reflect upon how the whole spliceosome may be affected. We compiled the list of all spliceosomal factors using Gene Set Enrichment Analysis (GSEA) (Supplementary Table\u0026nbsp;4) and checked if alcohol has a concerted effect on spliceosomal proteome. Although there was a statistically significant reduction in global expression of spliceosomal mRNAome, the magnitude of decrease was only in the range 1\u0026ndash;7% (Fig.\u0026nbsp;\u003cspan refid=\"Fig7\" class=\"InternalRef\"\u003e7\u003c/span\u003e) suggesting that protein components of spliceosome are unlikely to be considerably affected by alcohol.\u003c/p\u003e\u003c/div\u003e\n\u003ch3\u003eEffect of alcohol on splicing-related lncRNAs\u003c/h3\u003e\n\u003cp\u003eWe observed substantial changes in hepatic lncRNAs in patients with ALD, which correlated with the severity of liver damage. In eASH, 1,108 lncRNAs were differentially expressed, in nsAH \u0026ndash; 1854, in sAH \u0026ndash; 3,349, and in exAH \u0026ndash; 3,353 (Supplementary Fig.\u0026nbsp;5). Furthermore, the proportion of altered lncRNAs biotypes was different between early and late stages of ALD: while in early stages the pseudogenes were most commonly affected, in non-severe and severe AH stages there was an increased involvement of long intergenic non-coding RNAs and antisense lncRNAs (Supplementary Fig.\u0026nbsp;5).\u003c/p\u003e\u003cp\u003eWe then aimed at analyzing if these alterations were also present in alcohol-related HCC. The analysis of gene expression profiles from TCGA showed that patients with HCC\u0026thinsp;+\u0026thinsp;AUD had 514 differentially-expressed lncRNAs in the liver. The comparison of 3,349 lncRNAs altered in sAH with 514 lncRNAs altered in HCC\u0026thinsp;+\u0026thinsp;AUD demonstrated that 101 were common in these two conditions (Supplementary Fig.\u0026nbsp;6). Finally, a lncRNA ontology revealed that these lncRNAs are functionally related to splicing, as 3 out of 5 top pathways were represented by splicing and RNA processing (Table\u0026nbsp;\u003cspan refid=\"Tab1\" class=\"InternalRef\"\u003e2\u003c/span\u003e).\u003c/p\u003e\n\u003ch3\u003eEffect of alcohol on oncogenes\u003c/h3\u003e\n\u003cp\u003eTo address to what extent alcohol-induced changes in the liver affect oncogenes and tumor suppressors, we aligned 14,100 genes altered in sAH with the list of 803 oncogenes from Oncogene Database \u003csup\u003e\u003cspan citationid=\"CR52\" class=\"CitationRef\"\u003e52\u003c/span\u003e\u003c/sup\u003e. 414 were differentially expressed in both conditions (data not shown) suggesting that alcohol-induced transcriptomic changes in the liver posttranscriptionally affect large portion of all cancer-related genes. At the same time, since different cancers are accompanied by specific oncogenes \u003csup\u003e\u003cspan citationid=\"CR53\" class=\"CitationRef\"\u003e53\u003c/span\u003e,\u003cspan citationid=\"CR54\" class=\"CitationRef\"\u003e54\u003c/span\u003e\u003c/sup\u003e, we thought that we should undertake the analysis of oncogenes specific for HCC. In the past few years, extensive efforts by TCGA revealed genes mutated in specific cancers \u003csup\u003e\u003cspan citationid=\"CR24\" class=\"CitationRef\"\u003e24\u003c/span\u003e,\u003cspan citationid=\"CR55\" class=\"CitationRef\"\u003e55\u003c/span\u003e,\u003cspan citationid=\"CR56\" class=\"CitationRef\"\u003e56\u003c/span\u003e\u003c/sup\u003e, and 26 genes were most commonly mutated in HCC \u003csup\u003e\u003cspan citationid=\"CR24\" class=\"CitationRef\"\u003e24\u003c/span\u003e\u003c/sup\u003e. Screened of these genes using our computational pipeline showed that 7 of them were differentially expressed and/or misspliced in eASH, 14 \u0026ndash; in nsAH, 17 \u0026ndash; in sAH, and 13 \u0026ndash; in exAH (Chi-square test\u0026thinsp;=\u0026thinsp;8.12, p\u0026thinsp;=\u0026thinsp;0.04, Table\u0026nbsp;\u003cspan refid=\"Tab2\" class=\"InternalRef\"\u003e3\u003c/span\u003e).\u003c/p\u003e\u003cp\u003eNext, we asked if such a dose-dependent effect is limited to cancer-related genes. We compiled and analyzed the list of 26 random genes which included at least one gene from each chromosome. The similar pattern of increase was found: 5 genes were affected in eASH, 8 \u0026ndash; nsAH, 9 \u0026ndash; in sAH, and 12 \u0026ndash; exAH (Chi-square\u0026thinsp;=\u0026thinsp;4.37, p\u0026thinsp;=\u0026thinsp;0.22, Supplementary Table\u0026nbsp;5). Furthermore, we analyzed 26 genes implicated in spermatogenesis (as a pathway unrelated to the liver) and 26 genes involved in gluconeogenesis (as a pathway related to the liver). For both pathways, we once again observed a similar pattern condition-dependent increase: in eASH-nsAH-sAH-exAH continuum, 6-13-13-14 genes were affected in spermatogenesis (Chi-square\u0026thinsp;=\u0026thinsp;13.91, p\u0026thinsp;=\u0026thinsp;0.003, Supplementary Table\u0026nbsp;6) and 7-14-16-14 \u0026ndash; in gluconeogenesis (Chi-square\u0026thinsp;=\u0026thinsp;7.19, p\u0026thinsp;=\u0026thinsp;0.06, Supplementary Table\u0026nbsp;7). We reasoned, therefore, that degree of damage is unrelated to the pathway and rather mirrors the number of genes affected in a specific alcohol-related hepatic disease. We set out to merge and count all differentially expressed and misspliced genes in every alcohol-induced liver condition. Results demonstrated that number of affected genes indeed increases with the severity of hepatic damage: 11.8% genes were affected in eASH, 20.1% \u0026ndash; in nsAH, 29.8 \u0026ndash; in sAH, and 27.7% \u0026ndash; in exAH (p\u0026thinsp;=\u0026thinsp;0, Supplementary Fig.\u0026nbsp;7).\u003c/p\u003e\u003cp\u003eNext, we asked if alcohol use may impart broader transcriptomic changes in HCC and compared gene expression profiles from HCC samples between patients with and without AUD. Analysis showed that patients with HCC\u0026thinsp;+\u0026thinsp;AUD have 2-fold increase in a number of differentially increased genes in comparison to patients with HCC alone (Supplementary Fig.\u0026nbsp;8).\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eThe salient findings of the current study are: 1) ALD is accompanied by pervasive changes in hepatic transcriptomes; 2) ALD is accompanied by genome-wide changes in splicing and expression of exons; 3) Alcohol suppresses hepatic expression of snRNAs of major and minor spliceosomes; 4) Alcohol does not affect expression of splicing factors; 5) Alcohol affects lncRNAs related to splicing, and 6) Alcohol posttranscriptionally affects genes involved in HCC.\u003c/p\u003e\u003cp\u003eIn the past few years, alcohol-induced changes in gene expression were relatively well studied in the brain. For example, gene expression profiling on the prefrontal cortex identified 129 altered genes in patients with AUD \u003csup\u003e\u003cspan citationid=\"CR57\" class=\"CitationRef\"\u003e57\u003c/span\u003e\u003c/sup\u003e. It was shown that alcohol-induced changes in the brain are dependent on a cellular lineage, as RNA sequencing demonstrated unique transcriptomic signatures in murine astrocytes \u003csup\u003e\u003cspan citationid=\"CR58\" class=\"CitationRef\"\u003e58\u003c/span\u003e\u003c/sup\u003e or microglial cells \u003csup\u003e\u003cspan citationid=\"CR59\" class=\"CitationRef\"\u003e59\u003c/span\u003e\u003c/sup\u003e. Furthermore, it was demonstrated in mice that alcohol exposure alters expression of microRNAs (miRs) in prefrontal cortex, nucleus accumbens, and amygdala and that affected miRomes matched expression profiles of protein-coding genes in corresponding regions \u003csup\u003e\u003cspan citationid=\"CR60\" class=\"CitationRef\"\u003e60\u003c/span\u003e\u003c/sup\u003e. In the current study, we show that alcohol causes genome-wide changes in the liver, and these changes appear to be far more pervasive than those in the brain as indicated by our own data from different brain regions \u003csup\u003e\u003cspan citationid=\"CR41\" class=\"CitationRef\"\u003e41\u003c/span\u003e\u003c/sup\u003e as well as by results from previous studies \u003csup\u003e\u003cspan additionalcitationids=\"CR58\" citationid=\"CR57\" class=\"CitationRef\"\u003e57\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR59\" class=\"CitationRef\"\u003e59\u003c/span\u003e\u003c/sup\u003e. As of now, it is not known how alcohol may affect gene expression in the liver. Besides splicing, which was the focus of the current study, there are other molecular mechanisms that might be involved. For example, alcohol is associated with aberrant patterns of DNA methylation of CpG islands \u003csup\u003e\u003cspan citationid=\"CR61\" class=\"CitationRef\"\u003e61\u003c/span\u003e,\u003cspan citationid=\"CR62\" class=\"CitationRef\"\u003e62\u003c/span\u003e\u003c/sup\u003e and changes in histone code \u003csup\u003e\u003cspan citationid=\"CR63\" class=\"CitationRef\"\u003e63\u003c/span\u003e\u003c/sup\u003e; as mentioned, alcohol is also capable of changing the expression of miRs which fine-tune the transcriptome in the cytoplasm \u003csup\u003e\u003cspan citationid=\"CR60\" class=\"CitationRef\"\u003e60\u003c/span\u003e\u003c/sup\u003e. Of note, as extent of transcriptomic damage appears to be distinctly different in the liver and brain, it is possible that mechanism of alcohol-induced changes may be organ-specific and should likely be studied separately across specific tissues.\u003c/p\u003e\u003cp\u003eSplicing takes a central place in a cellular biology: constitutive splicing is responsible for a removal of introns, and alternative splicing generates a proteomic diversity. We observed that in addition to changes in gene expression, alcohol caused multiple missplicing events. There have been very few studies on the effect of alcohol on splicing, and initial investigations mainly focused on missplicing of specific genes. Thus, alcohol was shown to be associated with a missplicing of AMPA receptors \u003csup\u003e\u003cspan citationid=\"CR38\" class=\"CitationRef\"\u003e38\u003c/span\u003e\u003c/sup\u003e and GABA-B receptors \u003csup\u003e\u003cspan citationid=\"CR39\" class=\"CitationRef\"\u003e39\u003c/span\u003e\u003c/sup\u003e. Ethanol also affected alternative splicing of DRD2 (dopamine D2 receptor) in the pituitary \u003csup\u003e\u003cspan citationid=\"CR64\" class=\"CitationRef\"\u003e64\u003c/span\u003e\u003c/sup\u003e. Later, it was established that alcohol impacts splicing on a broader scale. Kawasawa et al. \u003csup\u003e\u003cspan citationid=\"CR40\" class=\"CitationRef\"\u003e40\u003c/span\u003e\u003c/sup\u003e found 382 alternative splicing events in the brain cortex of human fetuses exposed to alcohol. Qualitatively, 8 missplicing events were detected: 5\u0026rsquo;-SS, 3\u0026rsquo;-SS, MEE, IR, cassette exon, coordinate cassette exon, alternative first exon, and alternative last exon (ES was likely not detectable by employed computational pipeline), with IR being the most frequent event. In our previous work, we observed that AUD caused a genome-wide missplicing in different brain regions, most commonly \u0026ndash; ES and MEE \u003csup\u003e\u003cspan citationid=\"CR41\" class=\"CitationRef\"\u003e41\u003c/span\u003e\u003c/sup\u003e. In the current study, analysis of hepatic transcriptomes revealed that ES and MEE were again the major alcohol-induced events. These results are different from the missplicing patterns of another alcohol-related cancer, HNSCC, which also was associated with genome-wide changes in splicing, but alternative splice sites (5\u0026rsquo;-SS and 3\u0026rsquo;-SS) and canonical exon skipping were the most common missplicing events \u003csup\u003e\u003cspan citationid=\"CR65\" class=\"CitationRef\"\u003e65\u003c/span\u003e\u003c/sup\u003e. It appears that mechanism, extent, and landscape of alcohol-induced missplicing may differ from one tissue to another.\u003c/p\u003e\u003cp\u003eScattered data indicate that aberrant splicing in HCC may be a result of a damaged spliceosome; for example, HCC is frequently associated with mutations in splicing factor SF3B1 \u003csup\u003e24,66\u003c/sup\u003e. The effect of alcohol on spliceosome has not been well studied, but indirect evidence suggests that the link between AUD and spliceosomal activity may exist. It was shown that vulnerability of neuroprogenitor cells to toxic effects of alcohol was related to the expression of genes related to spliceosome \u003csup\u003e\u003cspan citationid=\"CR67\" class=\"CitationRef\"\u003e67\u003c/span\u003e\u003c/sup\u003e. It was also shown that exposure of neurons to alcohol reduced the expression of SRSF1 \u003csup\u003e68\u003c/sup\u003e. Likewise, in murine placenta and embryos, alcohol affected several spliceosomal genes including SRSF1 \u003csup\u003e69\u003c/sup\u003e. In our study, we did not see differential expression in cancer-related splicing factors (SF1, SF3B1, SRSF1, SRSF2, SRSF3, U2AF1, and ZRSR2); neither did we see any change in the expression of all components of the spliceosomal proteome. Instead, we observed that alcohol imparted a marked decrease of snRNAs. That snRNAs were affected and splicing factors were not and it was still induced broad missplicing events suggests a primary role of snRNAs in splicing. It is difficult to address if suppression of snRNAs is the only mechanism of missplicing in AUD. Such an experiment would likely require the \u0026ldquo;snRNAome rescue\u0026rdquo; experiment, and a precise normalization snRNAome may be technically hard to achieve.\u003c/p\u003e\u003cp\u003eHCC has the second highest worldwide cancer mortality rate, and therapeutic options for metastatic HCC are very limited and modestly efficacious. Many drugs failed to demonstrate efficacy in phase III \u003csup\u003e\u003cspan citationid=\"CR70\" class=\"CitationRef\"\u003e70\u003c/span\u003e\u003c/sup\u003e, likely due to incomplete understanding of mechanisms of HCC in AUD. One explanation of such a poor insight may be a traditional focus on DNA mutations as a driving force of carcinogenesis. Many studies question such an approach. TCGA work on HCC showed that many patients without p53 mutation have inactive functional p53 \u003csup\u003e24\u003c/sup\u003e suggesting that oncogenes may be affected via posttranscriptional mechanism, including splicing. HCC was previously shown to be accompanied by a dysregulated expression of splice isoforms of various genes including DNMT3b, TP53, KLF6 \u003csup\u003e71\u003c/sup\u003e, ketohexokinase \u003csup\u003e\u003cspan citationid=\"CR72\" class=\"CitationRef\"\u003e72\u003c/span\u003e\u003c/sup\u003e, and hepcidin \u003csup\u003e\u003cspan citationid=\"CR73\" class=\"CitationRef\"\u003e73\u003c/span\u003e\u003c/sup\u003e. It is possible that AUD-induced HCC represents a separate entity different from, for example, HCC associated with hepatitis C. Such a scenario was shown for esophageal squamous cell carcinoma in which genome sequencing identified six mutational signatures, with one of them specifically linked to alcohol intake \u003csup\u003e\u003cspan citationid=\"CR74\" class=\"CitationRef\"\u003e74\u003c/span\u003e\u003c/sup\u003e. Clearly, other genetic and epigenetic mechanisms are implicated and should be evaluated. For example, it was found that impaired functional status of p53 protein in patients with HCC and non-mutated TP53 could at least partly be attributed to high levels of MDM4, a p53 inhibitor \u003csup\u003e\u003cspan citationid=\"CR24\" class=\"CitationRef\"\u003e24\u003c/span\u003e\u003c/sup\u003e. One could speculate that each of tumor suppressors (oncogenes) involved in HCC may have protein inhibitors (activators). Also, it was shown that alcohol affects such processes related to gene-to-protein flow as RNA transport, ribosomes, and protein processing in the endoplasmic reticulum \u003csup\u003e\u003cspan citationid=\"CR67\" class=\"CitationRef\"\u003e67\u003c/span\u003e\u003c/sup\u003e, and it might be of interest to assess a relative contribution of these mechanisms in processing of HCC-related genes.\u003c/p\u003e\u003cp\u003eIn the current study, patients with eASH, nsAH, sAH, and exAH did not differ in terms of alcohol use which is in line with previous findings demonstrating the lack of correlation between alcohol intake and incidence/severity of AH \u003csup\u003e\u003cspan citationid=\"CR75\" class=\"CitationRef\"\u003e75\u003c/span\u003e,\u003cspan citationid=\"CR76\" class=\"CitationRef\"\u003e76\u003c/span\u003e\u003c/sup\u003e. Why are transcriptional and splicing landscapes so different in patients with similar alcohol intake? One may speculate that it is likely related to a genetic predisposition to missplicing. Since splicing is regulated by spliceosome, culprit(s) should be either snRNAs and/or splicing factors. We observed that splicing factors were not affected in all groups. We did not analyze snRNAome in human RNA sequencing datasets, but we cannot rule out the possibility that mutations in genomic snRNAs genes may be involved, and this would warrant a further investigation. It is of interest that both spliceosomes were affected in mice exposed to alcohol suggesting a common mechanism by which AUD may downregulate spliceosomes. Such a mechanism may involve transcription factor(s) orchestrating transcription of snRNAs. Another, posttranscriptional, mechanism of regulation may be represented by lncRNAs. Spliceosome represents a gigantic machinery consisting of snRNAs and splicing factors, and it is functionally coupled with gene expression \u003csup\u003e\u003cspan citationid=\"CR77\" class=\"CitationRef\"\u003e77\u003c/span\u003e\u003c/sup\u003e. Since lncRNAs can interact with DNA, RNA, and proteins, it is possible that they serve as master regulator of spliceosome. In our work, distribution of altered lncRNAomes differed between groups, with pseudogenes dominating early phase of alcohol-induced hepatic damage and lincRNAs and antisense lncRNA \u0026ndash; later phases. Some evidence indicates that even individual lncRNAs may cause changes in splicing. Thus, lncRNA MALAT1, an established oncogene activated in many cancers including HCC \u003csup\u003e\u003cspan citationid=\"CR78\" class=\"CitationRef\"\u003e78\u003c/span\u003e\u003c/sup\u003e and also upregulated in the brain of alcoholics \u003csup\u003e\u003cspan citationid=\"CR79\" class=\"CitationRef\"\u003e79\u003c/span\u003e\u003c/sup\u003e, affected splicing factors HNRNPF and HNRNPF1 as well as levels of serine-arginine-rich splicing factors and affected alternative splicing of hundreds of transcripts \u003csup\u003e\u003cspan citationid=\"CR80\" class=\"CitationRef\"\u003e80\u003c/span\u003e\u003c/sup\u003e. Alternative splicing is globally regulated by sno-lncRNAs, lncRNA flanked by small nucleolar RNA (snoRNAs) \u003csup\u003e\u003cspan citationid=\"CR81\" class=\"CitationRef\"\u003e81\u003c/span\u003e\u003c/sup\u003e which are a family of conserved nuclear RNAs located in Cajal bodies or nucleoli and participating in snRNAs modifications. Several lncRNAs are able to interact with specific splicing factors \u003csup\u003e\u003cspan citationid=\"CR82\" class=\"CitationRef\"\u003e82\u003c/span\u003e\u003c/sup\u003e. New exciting field is represented by circular RNAs (circRNAs), a covalently closed single-stranded RNA complexes arising from back-splicing. These complexes are highly stable, and it is speculated that they might be capable of competing with pre-mRNA for spliceosome \u003csup\u003e\u003cspan citationid=\"CR83\" class=\"CitationRef\"\u003e83\u003c/span\u003e\u003c/sup\u003e. We interrogated lncRNAs and found that lncRNAs affected in AUD and HCC\u0026thinsp;+\u0026thinsp;AUD were functionally related to splicing. The link between lncRNAs and spliceosomes is currently unknown. One possibility is that lncRNAs may function as \u0026ldquo;snRNAs sponges\u0026rdquo;, as a similar function was described for circRNAs which are capable of \u0026ldquo;sponging\u0026rdquo; miRs \u003csup\u003e\u003cspan citationid=\"CR84\" class=\"CitationRef\"\u003e84\u003c/span\u003e\u003c/sup\u003e.\u003c/p\u003e\u003cp\u003eOur tentative model is shown in Fig.\u0026nbsp;\u003cspan refid=\"Fig8\" class=\"InternalRef\"\u003e8\u003c/span\u003e. We showed that alcohol perturbs gene expression and splicing in genome-wide fashion across all alcohol-related hepatic diseases. Mechanistically, missplicing appears to be mediated by suppression of snRNAs of major and minor spliceosome. ALD was also associated with altered expression of lncRNAs, but the link between lncRNAs and spliceosome is to be elucidated. Among affected genes are oncogenes and tumor suppressors implicated in the development and progression of HCC.\u003c/p\u003e"},{"header":"Materials and Methods","content":"\u003cdiv id=\"Sec14\" class=\"Section2\"\u003e\u003ch2\u003ePatients\u003c/h2\u003e\u003cp\u003e All experiments have been conducted in accordance with the guidelines and regulations of Ethics Committees and Institutional Review Boards of the University of Miami and Linkoping University. RNA sequencing files from liver samples were obtained from the multicentric NIH-funded InTEAM Consortium and are available in the Database of Genotypes and Phenotypes (dbGAP, phs001807) \u003csup\u003e\u003cspan citationid=\"CR44\" class=\"CitationRef\"\u003e44\u003c/span\u003e\u003c/sup\u003e. Patients with non-severe (nsAH) and severe alcoholic hepatitis (sAH) as well as patients with liver failure who underwent liver transplantation were enrolled in the Consortium centers in Europe and United States. Samples from patients with early alcoholic steatohepatitis (eASH) were obtained from Cliniques Universitaires Saint-Luc (Brussels, Belgium). In total, 62 patients were included in this study. Written informed consent was obtained from all patients, and research protocols were approved by the local Ethics Committees and by the central Institutional Review Board of the University of North Carolina at Chapel Hill. Patients were selected according to different clinically relevant stage groups: patients with eASH who were non-obese with high alcohol intake and presented with a mild elevation of transaminases and histologic criteria of steatohepatitis (n\u0026thinsp;=\u0026thinsp;12); patients with nsAH and sAH who were biopsied before any treatment (n\u0026thinsp;=\u0026thinsp;11 for nsAH and n\u0026thinsp;=\u0026thinsp;18 for sAH); and explants from patients with AH who underwent early transplantation due to a liver failure following a well-defined protocol \u003csup\u003e\u003cspan citationid=\"CR85\" class=\"CitationRef\"\u003e85\u003c/span\u003e\u003c/sup\u003e (exAH, n\u0026thinsp;=\u0026thinsp;11). Samples from these groups were compared with fragments of non-diseased human livers (n\u0026thinsp;=\u0026thinsp;10). Patients with malignancies were excluded from the study.\u003c/p\u003e\u003c/div\u003e\u003cdiv id=\"Sec15\" class=\"Section2\"\u003e\u003ch2\u003eSequencing of RNA from liver samples\u003c/h2\u003e\u003cp\u003eSequencing was performed using Illumina HiSeq2000 platform, as previously described \u003csup\u003e\u003cspan citationid=\"CR44\" class=\"CitationRef\"\u003e44\u003c/span\u003e\u003c/sup\u003e. Briefly, libraries were built using Illumina TruSeq Stranded Total RNA Ribo-Zero GOLD (Illumina). Sequencing was paired and multiplexed. 62 paired-end sequenced samples obtained an average of 36,9\u0026nbsp;million total reads.\u003c/p\u003e\u003c/div\u003e\u003cdiv id=\"Sec16\" class=\"Section2\"\u003e\u003ch2\u003eAnalysis of Transcriptome\u003c/h2\u003e\u003cp\u003eAlignment was performed with the STAR aligner (v.2.5.2a) against the hg19 human genome. Adapters were trimmed by TrimGalore. Raw counts were processed by the Bioconductor R package edgeR and normalized using the TMM method to produce CPM values. Differential expression was calculated using a negative binomial model, and a False Discovery Ratio (FDR) cutoff of \u0026lt;\u0026thinsp;0.05 was used to define statistical significance.\u003c/p\u003e\u003cp\u003eNext, we analyzed consistent transcriptomic changes across all groups using the Bayesian ANOVA for microarrays (BAM) methodology developed by our group \u003csup\u003e\u003cspan citationid=\"CR86\" class=\"CitationRef\"\u003e86\u003c/span\u003e\u003c/sup\u003e which employs a specific Bayesian hierarchical model oriented towards adaptive shrinkage. By using model averaging, BAM-provided gene effect estimates are shrunken relative to the standard least square estimates. In this process, primarily the non-differentially expressing gene effects are shrunken. Such a selective shrinkage enabled BAM to optimally balance the total false detections (total number of genes falsely identified as being differentially expressed) against total false non-detections (the total number of genes falsely identified as being non-differentially expressed). This model enabled BAM to use data across all genes and all experimental groups to accurately estimate different levels of sparsity and then to selectively shrink gene effects based on the estimated complexities. BAM estimated gene differential effects (Zcut values) represented the products of posterior inference from the BAM hierarchical Bayesian model. Shrinkage plots were used to identify differentially expressed genes. Significant genes were grouped by differential expression pattern type.\u003c/p\u003e\u003c/div\u003e\u003cdiv id=\"Sec17\" class=\"Section2\"\u003e\u003ch2\u003eGene Ontology of protein-coding genes\u003c/h2\u003e\u003cp\u003eFunctional analysis of altered transcripts was performed by Gene Ontology Consortium, as described elsewhere \u003csup\u003e\u003cspan citationid=\"CR87\" class=\"CitationRef\"\u003e87\u003c/span\u003e,\u003cspan citationid=\"CR88\" class=\"CitationRef\"\u003e88\u003c/span\u003e\u003c/sup\u003e. Hierarchy of implicated Gene Ontology terms was constructed using default criteria set by developers.\u003c/p\u003e\u003c/div\u003e\u003cdiv id=\"Sec18\" class=\"Section2\"\u003e\u003ch2\u003eAnalysis of missplicing events\u003c/h2\u003e\u003cp\u003eAlignment was performed with the STAR aligner (v.2.5.2a) against the hg19 human genome. Resulting bam files from the STAR alignment were indexed with samtools for use by rMATS, as described elsewhere \u003csup\u003e\u003cspan citationid=\"CR45\" class=\"CitationRef\"\u003e45\u003c/span\u003e\u003c/sup\u003e. Briefly, rMATS pipeline used RNA sequencing reads which were mapped to different splice variants to estimate the isoform proportion, and a hierarchical framework was employed to simultaneously account for estimation uncertainty in individual replicates and variability among replicates. FDR cutoff\u0026thinsp;\u0026lt;\u0026thinsp;0.05 was used to define statistical significance.\u003c/p\u003e\u003c/div\u003e\u003cdiv id=\"Sec19\" class=\"Section2\"\u003e\u003ch2\u003eExon expression\u003c/h2\u003e\u003cp\u003eAnalysis of the expression of exons was performed as described elsewhere \u003csup\u003e\u003cspan citationid=\"CR89\" class=\"CitationRef\"\u003e89\u003c/span\u003e\u003c/sup\u003e. Alignment was performed with the STAR aligner (v.2.5.2a) against the hg19 human genome. Adapters were trimmed by TrimGalore. Raw counts were obtained from the dexseq_count.py script contained in the DEXSeq R package (v.1.20.2) on the reference annotation prepared by the dexseq_prepare_annotation.py script in the same package against the GENCODE reference file (v.19). These counts were then fed into DEXSeq to determine exon-specific differential splicing events. Figures were generated using the plotDEXSeq function contained in the DEXSeq package. FDR cutoff\u0026thinsp;\u0026lt;\u0026thinsp;0.05 was used to define statistical significance.\u003c/p\u003e\u003c/div\u003e\u003cdiv id=\"Sec20\" class=\"Section2\"\u003e\u003ch2\u003eRat model of alcohol use disorder based on vapor chamber\u003c/h2\u003e\u003cp\u003e Experiments on animals have been approved by the Institutional Review Board of the Linkoping University and have been carried out in full accord with relevant guidelines and regulations. All methods are reported in accordance with ARRIVE guidelines and regulations \u003csup\u003e\u003cspan citationid=\"CR90\" class=\"CitationRef\"\u003e90\u003c/span\u003e\u003c/sup\u003e. Rats were placed in a vapor chamber with a normal air for one week for a habituation to a new environment (two rats per cage). Then alcohol vapor exposure was slowly increased in the course of 1 week until blood alcohol concentration (BAC) reached\u0026thinsp;~\u0026thinsp;200 mg/dL. Rats were exposed to alcohol vapor for 7 weeks (5 days a week, 14 hours/day) or left unexposed (n\u0026thinsp;=\u0026thinsp;12 in each group). BAC was measured once per week from one rat per cage (rats were alternating every other week). One week after the last alcohol exposure, animals were sacrificed, and liver and lung samples were collected.\u003c/p\u003e\u003c/div\u003e\u003cdiv id=\"Sec21\" class=\"Section2\"\u003e\u003ch2\u003eRNA isolation\u003c/h2\u003e\u003cp\u003eRNA was isolated from liver and lung by Qiagen RNeasy kit, in accordance to manufacturer\u0026rsquo;s instructions. Prior to RNA isolation, samples were incubated in RNAlater-ICE (Thermo Fisher Scientific) overnight at -20\u0026deg;C. DNase treatment was performed using RNase-Free DNase Set (Qiagen). RNA quality and concentrations were determined by Nanodrop 2000, and samples with RNA Integrity Number (A260:A280 ratio) between 1.9\u0026ndash;2.1 were included in the study. RNA samples were kept at -80\u0026deg;C until analyzed.\u003c/p\u003e\u003c/div\u003e\u003cdiv id=\"Sec22\" class=\"Section2\"\u003e\u003ch2\u003eQuantitative real-time PCR (qRT-PCR)\u003c/h2\u003e\u003cp\u003eRNA was reversely transcribed using High Capacity cDNA Reverse Transcription Kit (Thermo Fisher Scientific); reactions were run on a Veriti 96 Well Fast Thermal Cycler (Applied Biosystems); cycling conditions were 25\u0026deg;C for 10 minutes, 37\u0026deg;C for 2 hours, and 85\u0026deg;C for 5 minutes. For real-time PCR, cDNA was mixed with a master mix consisting of TaqMan Universal PCR Master Mix (Roche), nuclease-free water, and 20X or 40 X TaqMan primers. qRT-PCR was performed on QuantStudio 6 Flex (Thermo Fisher Scientific) using probe-based assays from Integrated DNA Technologies. Cycling conditions were 50\u0026deg;C for 2 minutes, 95\u0026deg;C for 10 minutes, and 40 cycles of 95\u0026deg;C for 15 seconds and 60\u0026deg;C for 1 minute. Data were analyzed using the comparative threshold cycle (ΔΔCT) method, as described previously \u003csup\u003e\u003cspan citationid=\"CR91\" class=\"CitationRef\"\u003e91\u003c/span\u003e\u003c/sup\u003e, normalized to β-actin, and expressed relatively to a control group. Primers for protein-coding genes were purchased from a pre-made stock of Integrated DNA Technologies. Primers for human and rat snRNAs were designed either by ourselves or by Integrated DNA Technologies, and their sequences are listed in Supplementary Table\u0026nbsp;8.\u003c/p\u003e\u003c/div\u003e\u003cdiv id=\"Sec23\" class=\"Section2\"\u003e\u003ch2\u003eComputational Analysis of Coding and Non-coding Features\u003c/h2\u003e\u003cp\u003eThe Cancer Genome Atlas (TCGA, \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e\u003ca href=\"http://www.cancer.gov/tcga\" target=\"_blank\"\u003ewww.cancer.gov/tcga\u003c/a\u003e\u003c/span\u003e\u003cspan address=\"http://www.cancer.gov/tcga\" targettype=\"URL\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e) was used to retrieve RNA sequencing files from patients with HCC and HCC\u0026thinsp;+\u0026thinsp;AUD. For most patients with HCC, alcohol intake was well documented on TCGA; however, since DSM-5-defined criteria of AUD were not included in TCGA social history, we arbitrarily defined AUD group as individuals consuming 4 or more drinks a day at least 4 days a week; control group included subjects with no alcohol intake. Other inclusion criterion was being alive at the time of cancerous tissue harvest (to avoid possible RNA degradation in postmortem samples). 10 patients were included in each group. All datasets incorporated in the analysis were generated by aligning reads to GRCh38 using STAR; genes were annotated using GENCODE v.22, and their expression was presented in a FPKM-UQ format.\u003c/p\u003e\u003cp\u003eGene Set Enrichment Analysis database \u003csup\u003e\u003cspan citationid=\"CR92\" class=\"CitationRef\"\u003e92\u003c/span\u003e\u003c/sup\u003e was used to obtain the list of spliceosomal proteins and to create the lists of proteins involved in gluconeogenesis and spermatogenesis as well as the list of 26 random genes which included at least 1 gene from each chromosome. List of cancer-related genes was retrieved form the Oncogene Database \u003csup\u003e\u003cspan citationid=\"CR52\" class=\"CitationRef\"\u003e52\u003c/span\u003e\u003c/sup\u003e, a literature-based curated database of oncogenes and tumor suppressors. Functional status of altered lncRNAs of interest was studied using \u0026ldquo;LncRNA Ontology\u0026rdquo; database \u003csup\u003e\u003cspan citationid=\"CR93\" class=\"CitationRef\"\u003e93\u003c/span\u003e\u003c/sup\u003e which employs the pipeline based on transcriptional and epigenetic profiles of lncRNAs and protein-coding genes; default criteria set by developers were used to execute the ontology.\u003c/p\u003e\u003c/div\u003e\u003cdiv id=\"Sec24\" class=\"Section2\"\u003e\u003ch2\u003eStatistical Analysis\u003c/h2\u003e\u003cp\u003eStatistical analysis between two groups was performed using two-tailed Student\u0026rsquo;s \u003cem\u003et\u003c/em\u003e test. Data are expressed as mean\u0026thinsp;\u0026plusmn;\u0026thinsp;SEM unless otherwise stated. Proportions in events in different groups were assessed using chi-square test; rejection of the null hypothesis (that proportions are the same across groups) indicated that proportion is different in at least one group. Difference between expression of splicing factors was determined using the Test for Fold Change of Two Means. Differences with \u003cem\u003eP\u003c/em\u003e\u0026thinsp;\u0026lt;\u0026thinsp;0.05 were considered to be statistically significant.\u003c/p\u003e\u003c/div\u003e"},{"header":"Declarations","content":"\u003cp\u003eSources of funding\u003c/p\u003e\n\u003cp\u003eThis work was supported by HIN grant R01AA029924. \u0026nbsp;\u003c/p\u003e\n\u003cp\u003eCompeting Interests Statement\u003c/p\u003e\n\u003cp\u003eThe authors declare no competing interests.\u003c/p\u003e\u003ch2\u003eAuthor Contribution\u003c/h2\u003e\u003cp\u003eIOB, DVB, and CW developed the concept and designed the study; IOB, DVB, JA, ML, JSR, EB, EB, MH, and RB collected and/or analyzed datasets; IOB, DVB, JC, ABD, and CW interpreted results; IOB and CW wrote the manuscript.\u003c/p\u003e\u003ch2\u003eData Availability\u003c/h2\u003e\u003cp\u003eRNA sequencing files from liver samples were obtained from the multicentric NIH-funded InTEAM Consortium and are available in the Database of Genotypes and Phenotypes (dbGAP, phs001807).\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\u003cli\u003e\u003cspan\u003eAnderson, B. O. et al. Health and cancer risks associated with low levels of alcohol consumption. \u003cem\u003eLancet Public. Health\u003c/em\u003e. \u003cb\u003e8\u003c/b\u003e, e6\u0026ndash;e7. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1016/s2468-2667(22)00317-6\u003c/span\u003e\u003cspan address=\"10.1016/s2468-2667(22)00317-6\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2023).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eGrant, B. F. et al. Epidemiology of DSM-5 Alcohol Use Disorder: Results From the National Epidemiologic Survey on Alcohol and Related Conditions III. \u003cem\u003eJAMA Psychiatry\u003c/em\u003e. \u003cb\u003e72\u003c/b\u003e, 757\u0026ndash;766. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1001/jamapsychiatry.2015.0584\u003c/span\u003e\u003cspan address=\"10.1001/jamapsychiatry.2015.0584\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2015).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eGrant, B. F. et al. Prevalence of 12-Month Alcohol Use, High-Risk Drinking, and DSM-IV Alcohol Use Disorder in the United States, 2001\u0026ndash;2002 to 2012\u0026ndash;2013: Results From the National Epidemiologic Survey on Alcohol and Related Conditions. \u003cem\u003eJAMA psychiatry\u003c/em\u003e 74, 911\u0026ndash;923, (2017). \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1001/jamapsychiatry.2017.2161\u003c/span\u003e\u003cspan address=\"10.1001/jamapsychiatry.2017.2161\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eMekonen, T. et al. Treatment rates for alcohol use disorders: a systematic review and meta-analysis. \u003cem\u003eAddiction\u003c/em\u003e \u003cb\u003e116\u003c/b\u003e, 2617\u0026ndash;2634. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1111/add.15357\u003c/span\u003e\u003cspan address=\"10.1111/add.15357\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2021).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eCrowley, R., Hilden, D. \u0026amp; Beachy, M. Excessive Alcohol Use and Alcohol Use Disorders: A Policy Brief of the American College of Physicians. \u003cem\u003eAnn. Intern. Med.\u003c/em\u003e \u003cb\u003e177\u003c/b\u003e, 656\u0026ndash;657. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.7326/m23-3434\u003c/span\u003e\u003cspan address=\"10.7326/m23-3434\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2024).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eSacks, J. J., Gonzales, K. R., Bouchery, E. E., Tomedi, L. E. \u0026amp; Brewer, R. D. 2010 National and State Costs of Excessive Alcohol Consumption. \u003cem\u003eAm. J. Prev. Med.\u003c/em\u003e \u003cb\u003e49\u003c/b\u003e, e73\u0026ndash;e79. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1016/j.amepre.2015.05.031\u003c/span\u003e\u003cspan address=\"10.1016/j.amepre.2015.05.031\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2015).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eLi, M., Peterson, C., Xu, L., Mikosz, C. A. \u0026amp; Luo, F. Medical Costs of Substance Use Disorders in the US Employer-Sponsored Insurance Population. \u003cem\u003eJAMA Netw. Open.\u003c/em\u003e \u003cb\u003e6\u003c/b\u003e, e2252378. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1001/jamanetworkopen.2022.52378\u003c/span\u003e\u003cspan address=\"10.1001/jamanetworkopen.2022.52378\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2023).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eSeitz, H. K. et al. Alcoholic liver disease. \u003cem\u003eNat. Rev. Dis. Primers\u003c/em\u003e. \u003cb\u003e4\u003c/b\u003e, 16. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1038/s41572-018-0014-7\u003c/span\u003e\u003cspan address=\"10.1038/s41572-018-0014-7\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2018).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eMittal, S. et al. Hepatocellular Carcinoma in the Absence of Cirrhosis in United States Veterans is Associated With Nonalcoholic Fatty Liver Disease. \u003cem\u003eClin. Gastroenterol. hepatology: official Clin. Pract. J. Am. Gastroenterological Association\u003c/em\u003e. \u003cb\u003e14\u003c/b\u003e, 124\u0026ndash;131e121. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1016/j.cgh.2015.07.019\u003c/span\u003e\u003cspan address=\"10.1016/j.cgh.2015.07.019\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2016).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eTokushige, K. et al. Hepatocellular carcinoma in Japanese patients with nonalcoholic fatty liver disease and alcoholic liver disease: multicenter survey. \u003cem\u003eJ. Gastroenterol.\u003c/em\u003e \u003cb\u003e51\u003c/b\u003e, 586\u0026ndash;596. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1007/s00535-015-1129-1\u003c/span\u003e\u003cspan address=\"10.1007/s00535-015-1129-1\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2016).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eBosetti, C., Turati, F. \u0026amp; La Vecchia, C. Hepatocellular carcinoma epidemiology. \u003cem\u003eBest Pract. Res. Clin. Gastroenterol.\u003c/em\u003e \u003cb\u003e28\u003c/b\u003e, 753\u0026ndash;770. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1016/j.bpg.2014.08.007\u003c/span\u003e\u003cspan address=\"10.1016/j.bpg.2014.08.007\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2014).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eSamant, H., Amiri, H. S. \u0026amp; Zibari, G. B. Addressing the worldwide hepatocellular carcinoma: epidemiology, prevention and management. \u003cem\u003eJ. Gastrointest. Oncol.\u003c/em\u003e \u003cb\u003e12\u003c/b\u003e, S361\u0026ndash;s373. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.21037/jgo.2020.02.08\u003c/span\u003e\u003cspan address=\"10.21037/jgo.2020.02.08\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2021).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eLlovet, J. M. et al. Sorafenib in advanced hepatocellular carcinoma. \u003cem\u003eN. Engl. J. Med.\u003c/em\u003e \u003cb\u003e359\u003c/b\u003e, 378\u0026ndash;390. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1056/NEJMoa0708857\u003c/span\u003e\u003cspan address=\"10.1056/NEJMoa0708857\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2008).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eKudo, M. et al. Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial. \u003cem\u003eLancet\u003c/em\u003e \u003cb\u003e391\u003c/b\u003e, 1163\u0026ndash;1173. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1016/s0140-6736(18)30207-1\u003c/span\u003e\u003cspan address=\"10.1016/s0140-6736(18)30207-1\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2018).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eEl-Khoueiry, A. B. et al. Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial. \u003cem\u003eLancet (London England)\u003c/em\u003e. \u003cb\u003e389\u003c/b\u003e, 2492\u0026ndash;2502. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1016/s0140-6736(17)31046-2\u003c/span\u003e\u003cspan address=\"10.1016/s0140-6736(17)31046-2\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2017).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eAbou-Alfa, G. K. et al. Tremelimumab plus Durvalumab in Unresectable Hepatocellular Carcinoma. \u003cem\u003eNEJM Evid.\u003c/em\u003e \u003cb\u003e1\u003c/b\u003e, EVIDoa2100070. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1056/EVIDoa2100070\u003c/span\u003e\u003cspan address=\"10.1056/EVIDoa2100070\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2022).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eBrown, Z. J. et al. Management of Hepatocellular Carcinoma: A Review. \u003cem\u003eJAMA Surg.\u003c/em\u003e \u003cb\u003e158\u003c/b\u003e, 410\u0026ndash;420. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1001/jamasurg.2022.7989\u003c/span\u003e\u003cspan address=\"10.1001/jamasurg.2022.7989\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2023).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eDhanasekaran, R., Limaye, A. \u0026amp; Cabrera, R. Hepatocellular carcinoma: current trends in worldwide epidemiology, risk factors, diagnosis, and therapeutics. \u003cem\u003eHepatic medicine: Evid. Res.\u003c/em\u003e \u003cb\u003e4\u003c/b\u003e, 19\u0026ndash;37. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.2147/hmer.S16316\u003c/span\u003e\u003cspan address=\"10.2147/hmer.S16316\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2012).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eOh, J. H. \u0026amp; Jun, D. W. The latest global burden of liver cancer: A past and present threat. \u003cem\u003eClin. Mol. Hepatol.\u003c/em\u003e \u003cb\u003e29\u003c/b\u003e, 355\u0026ndash;357. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.3350/cmh.2023.0070\u003c/span\u003e\u003cspan address=\"10.3350/cmh.2023.0070\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2023).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eHassan, M. M. et al. Risk factors for hepatocellular carcinoma: synergism of alcohol with viral hepatitis and diabetes mellitus. \u003cem\u003eHepatology\u003c/em\u003e \u003cb\u003e36\u003c/b\u003e, 1206\u0026ndash;1213. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1053/jhep.2002.36780\u003c/span\u003e\u003cspan address=\"10.1053/jhep.2002.36780\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2002).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eChuang, S. C., Lee, Y. C., Wu, G. J., Straif, K. \u0026amp; Hashibe, M. Alcohol consumption and liver cancer risk: a meta-analysis. \u003cem\u003eCancer Causes Control\u003c/em\u003e. \u003cb\u003e26\u003c/b\u003e, 1205\u0026ndash;1231. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1007/s10552-015-0615-3\u003c/span\u003e\u003cspan address=\"10.1007/s10552-015-0615-3\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2015).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eMarot, A., Henrion, J., Knebel, J. F., Moreno, C. \u0026amp; Deltenre, P. Alcoholic liver disease confers a worse prognosis than HCV infection and non-alcoholic fatty liver disease among patients with cirrhosis: An observational study. \u003cem\u003ePloS one\u003c/em\u003e. \u003cb\u003e12\u003c/b\u003e, e0186715. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1371/journal.pone.0186715\u003c/span\u003e\u003cspan address=\"10.1371/journal.pone.0186715\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2017).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eWest, J., Card, T. R., Aithal, G. P. \u0026amp; Fleming, K. M. Risk of hepatocellular carcinoma among individuals with different aetiologies of cirrhosis: a population-based cohort study. \u003cem\u003eAliment. Pharmacol. Ther.\u003c/em\u003e \u003cb\u003e45\u003c/b\u003e, 983\u0026ndash;990. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1111/apt.13961\u003c/span\u003e\u003cspan address=\"10.1111/apt.13961\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2017).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eComprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma. \u003cem\u003eCell\u003c/em\u003e \u003cb\u003e169\u003c/b\u003e, 1327\u0026ndash;1341e1323, doi:\u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1016/j.cell.2017.05.046\u003c/span\u003e\u003cspan address=\"10.1016/j.cell.2017.05.046\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2017).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eRamadori, P., Cubero, F. J., Liedtke, C., Trautwein, C. \u0026amp; Nevzorova, Y. A. Alcohol and Hepatocellular Carcinoma: Adding Fuel to the Flame. \u003cem\u003eCancers\u003c/em\u003e \u003cb\u003e9\u003c/b\u003e \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.3390/cancers9100130\u003c/span\u003e\u003cspan address=\"10.3390/cancers9100130\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2017).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eWill, C. L. \u0026amp; Luhrmann, R. Spliceosome structure and function. \u003cem\u003eCold Spring Harb Perspect. Biol.\u003c/em\u003e \u003cb\u003e3\u003c/b\u003e \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1101/cshperspect.a003707\u003c/span\u003e\u003cspan address=\"10.1101/cshperspect.a003707\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2011).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eAnczukow, O. \u0026amp; Krainer, A. R. Splicing-factor alterations in cancers. \u003cem\u003eRNA (New York N Y)\u003c/em\u003e. \u003cb\u003e22\u003c/b\u003e, 1285\u0026ndash;1301. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1261/rna.057919.116\u003c/span\u003e\u003cspan address=\"10.1261/rna.057919.116\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2016).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eDvinge, H., Kim, E., Abdel-Wahab, O. \u0026amp; Bradley, R. K. RNA splicing factors as oncoproteins and tumour suppressors. \u003cem\u003eNat. Rev. Cancer\u003c/em\u003e. \u003cb\u003e16\u003c/b\u003e, 413\u0026ndash;430. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1038/nrc.2016.51\u003c/span\u003e\u003cspan address=\"10.1038/nrc.2016.51\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2016).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eZhang, Q., Ai, Y. \u0026amp; Abdel-Wahab, O. Molecular impact of mutations in RNA splicing factors in cancer. \u003cem\u003eMol. Cell.\u003c/em\u003e \u003cb\u003e84\u003c/b\u003e, 3667\u0026ndash;3680. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1016/j.molcel.2024.07.019\u003c/span\u003e\u003cspan address=\"10.1016/j.molcel.2024.07.019\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2024).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eWahl, M. C., Will, C. L. \u0026amp; Luhrmann, R. The spliceosome: design principles of a dynamic RNP machine. \u003cem\u003eCell\u003c/em\u003e \u003cb\u003e136\u003c/b\u003e, 701\u0026ndash;718. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1016/j.cell.2009.02.009\u003c/span\u003e\u003cspan address=\"10.1016/j.cell.2009.02.009\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2009).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eTwyffels, L., Gueydan, C., Kruys, V. \u0026amp; Shuttling SR proteins: more than splicing factors. \u003cem\u003eFEBS J.\u003c/em\u003e \u003cb\u003e278\u003c/b\u003e, 3246\u0026ndash;3255. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1111/j.1742-4658.2011.08274.x\u003c/span\u003e\u003cspan address=\"10.1111/j.1742-4658.2011.08274.x\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2011).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eMadan, V. et al. Aberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome. \u003cem\u003eNat. Commun.\u003c/em\u003e \u003cb\u003e6\u003c/b\u003e, 6042. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1038/ncomms7042\u003c/span\u003e\u003cspan address=\"10.1038/ncomms7042\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2015).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eOkeyo-Owuor, T. et al. U2AF1 mutations alter sequence specificity of pre-mRNA binding and splicing. \u003cem\u003eLeukemia\u003c/em\u003e \u003cb\u003e29\u003c/b\u003e, 909\u0026ndash;917. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1038/leu.2014.303\u003c/span\u003e\u003cspan address=\"10.1038/leu.2014.303\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2015).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eBlokhin, I., Khorkova, O., Hsiao, J. \u0026amp; Wahlestedt, C. Developments in lncRNA drug discovery: where are we heading? \u003cem\u003eExpert Opin. Drug Discov\u003c/em\u003e. \u003cb\u003e13\u003c/b\u003e, 837\u0026ndash;849. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1080/17460441.2018.1501024\u003c/span\u003e\u003cspan address=\"10.1080/17460441.2018.1501024\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2018).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eTsuiji, H. et al. Competition between a noncoding exon and introns: Gomafu contains tandem UACUAAC repeats and associates with splicing factor-1. \u003cem\u003eGenes cells: devoted Mol. Cell. Mech.\u003c/em\u003e \u003cb\u003e16\u003c/b\u003e, 479\u0026ndash;490. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1111/j.1365-2443.2011.01502.x\u003c/span\u003e\u003cspan address=\"10.1111/j.1365-2443.2011.01502.x\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2011).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eBernard, D. et al. A long nuclear-retained non-coding RNA regulates synaptogenesis by modulating gene expression. \u003cem\u003eEMBO J.\u003c/em\u003e \u003cb\u003e29\u003c/b\u003e, 3082\u0026ndash;3093. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1038/emboj.2010.199\u003c/span\u003e\u003cspan address=\"10.1038/emboj.2010.199\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2010).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eTripathi, V. et al. The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation. \u003cem\u003eMol. Cell\u003c/em\u003e. \u003cb\u003e39\u003c/b\u003e, 925\u0026ndash;938. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1016/j.molcel.2010.08.011\u003c/span\u003e\u003cspan address=\"10.1016/j.molcel.2010.08.011\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2010).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eAcosta, G., Freidman, D. P., Grant, K. A. \u0026amp; Hemby, S. E. Alternative splicing of AMPA subunits in prefrontal cortical fields of cynomolgus monkeys following chronic ethanol self-administration. \u003cem\u003eFront. Psychiatry\u003c/em\u003e. \u003cb\u003e2\u003c/b\u003e, 72. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.3389/fpsyt.2011.00072\u003c/span\u003e\u003cspan address=\"10.3389/fpsyt.2011.00072\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2011).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eLee, C., Mayfield, R. D. \u0026amp; Harris, R. A. Altered gamma-aminobutyric acid type B receptor subunit 1 splicing in alcoholics. \u003cem\u003eBiol. Psychiatry\u003c/em\u003e. \u003cb\u003e75\u003c/b\u003e, 765\u0026ndash;773. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1016/j.biopsych.2013.08.028\u003c/span\u003e\u003cspan address=\"10.1016/j.biopsych.2013.08.028\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2014).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eKawasawa, Y. I. et al. Genome-wide profiling of differentially spliced mRNAs in human fetal cortical tissue exposed to alcohol. \u003cem\u003eAlcohol (Fayetteville N Y)\u003c/em\u003e. \u003cb\u003e62\u003c/b\u003e, 1\u0026ndash;9. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1016/j.alcohol.2017.05.001\u003c/span\u003e\u003cspan address=\"10.1016/j.alcohol.2017.05.001\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2017).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eVan Booven, D. et al. Alcohol use disorder causes global changes in splicing in the human brain. \u003cem\u003eTransl Psychiatry\u003c/em\u003e. \u003cb\u003e11\u003c/b\u003e, 2. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1038/s41398-020-01163-z\u003c/span\u003e\u003cspan address=\"10.1038/s41398-020-01163-z\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2021).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eTremblay, M. P. et al. Global profiling of alternative RNA splicing events provides insights into molecular differences between various types of hepatocellular carcinoma. \u003cem\u003eBMC Genom.\u003c/em\u003e \u003cb\u003e17\u003c/b\u003e \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1186/s12864-016-3029-z\u003c/span\u003e\u003cspan address=\"10.1186/s12864-016-3029-z\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2016).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eZhu, G. Q. et al. Prognostic alternative mRNA splicing signature in hepatocellular carcinoma: a study based on large-scale sequencing data. \u003cem\u003eCarcinogenesis\u003c/em\u003e \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1093/carcin/bgz073\u003c/span\u003e\u003cspan address=\"10.1093/carcin/bgz073\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2019).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eArgemi, J. et al. Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis. \u003cem\u003eNat. Commun.\u003c/em\u003e \u003cb\u003e10\u003c/b\u003e, 3126. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1038/s41467-019-11004-3\u003c/span\u003e\u003cspan address=\"10.1038/s41467-019-11004-3\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2019).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eShen, S. et al. rMATS: robust and flexible detection of differential alternative splicing from replicate RNA-Seq data. \u003cem\u003eProc. Natl. Acad. Sci. U.S.A.\u003c/em\u003e \u003cb\u003e111\u003c/b\u003e, E5593\u0026ndash;5601. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1073/pnas.1419161111\u003c/span\u003e\u003cspan address=\"10.1073/pnas.1419161111\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2014).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eMorais, P., Adachi, H. \u0026amp; Yu, Y. T. Spliceosomal snRNA Epitranscriptomics. \u003cem\u003eFront. Genet.\u003c/em\u003e \u003cb\u003e12\u003c/b\u003e, 652129. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.3389/fgene.2021.652129\u003c/span\u003e\u003cspan address=\"10.3389/fgene.2021.652129\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2021).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eValadkhan, S. Role of the snRNAs in spliceosomal active site. \u003cem\u003eRNA Biol.\u003c/em\u003e \u003cb\u003e7\u003c/b\u003e, 345\u0026ndash;353. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.4161/rna.7.3.12089\u003c/span\u003e\u003cspan address=\"10.4161/rna.7.3.12089\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2010).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eHuggett, S. B., Ikeda, A. S., Yuan, Q., Benca-Bachman, C. E. \u0026amp; Palmer, R. H. C. Genome- and transcriptome-wide splicing associations with alcohol use disorder. \u003cem\u003eSci. Rep.\u003c/em\u003e \u003cb\u003e13\u003c/b\u003e, 3950. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1038/s41598-023-30926-z\u003c/span\u003e\u003cspan address=\"10.1038/s41598-023-30926-z\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2023).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eSchmidt-Heck, W. et al. Global Transcriptional Response of Human Liver Cells to Ethanol Stress of Different Strength Reveals Hormetic Behavior. \u003cem\u003eAlcohol. Clin. Exp. Res.\u003c/em\u003e \u003cb\u003e41\u003c/b\u003e, 883\u0026ndash;894. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1111/acer.13361\u003c/span\u003e\u003cspan address=\"10.1111/acer.13361\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2017).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eZhao, J., Peter, D., Brandina, I., Liu, X. \u0026amp; Galej, W. P. Structural basis of 5' splice site recognition by the minor spliceosome. \u003cem\u003eMol. Cell.\u003c/em\u003e \u003cb\u003e85\u003c/b\u003e, 652\u0026ndash;664e654. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1016/j.molcel.2024.12.017\u003c/span\u003e\u003cspan address=\"10.1016/j.molcel.2024.12.017\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2025).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eTurunen, J. J., Niemela, E. H., Verma, B. \u0026amp; Frilander, M. J. The significant other: splicing by the minor spliceosome. \u003cem\u003eWiley Interdiscip Rev. RNA\u003c/em\u003e. \u003cb\u003e4\u003c/b\u003e, 61\u0026ndash;76. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1002/wrna.1141\u003c/span\u003e\u003cspan address=\"10.1002/wrna.1141\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2013).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eLiu, Y., Sun, J., Zhao, M. \u0026amp; ONGene A literature-based database for human oncogenes. \u003cem\u003eJ. Genet. genomics = Yi chuan xue bao\u003c/em\u003e. \u003cb\u003e44\u003c/b\u003e, 119\u0026ndash;121. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1016/j.jgg.2016.12.004\u003c/span\u003e\u003cspan address=\"10.1016/j.jgg.2016.12.004\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2017).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eWang, F., Breslin, S. J. P. \u0026amp; Qiu, W. Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma. \u003cem\u003eLiver Res.\u003c/em\u003e \u003cb\u003e5\u003c/b\u003e, 195\u0026ndash;203. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1016/j.livres.2021.06.001\u003c/span\u003e\u003cspan address=\"10.1016/j.livres.2021.06.001\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2021).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eBreves, S. L. et al. Three-dimensional regulatory hubs support oncogenic programs in glioblastoma. \u003cem\u003eMol. Cell.\u003c/em\u003e \u003cb\u003e85\u003c/b\u003e, 1330\u0026ndash;1348e1336. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1016/j.molcel.2025.03.007\u003c/span\u003e\u003cspan address=\"10.1016/j.molcel.2025.03.007\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2025).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eIntegrated genomic characterization of oesophageal carcinoma. \u003cem\u003eNature\u003c/em\u003e \u003cb\u003e541\u003c/b\u003e, 169\u0026ndash;175, doi:\u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1038/nature20805\u003c/span\u003e\u003cspan address=\"10.1038/nature20805\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2017).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eIntegrated genomic and molecular characterization of cervical cancer. \u003cem\u003eNature\u003c/em\u003e \u003cb\u003e543\u003c/b\u003e, 378\u0026ndash;384, doi:\u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1038/nature21386\u003c/span\u003e\u003cspan address=\"10.1038/nature21386\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2017).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eKapoor, M. et al. Analysis of whole genome-transcriptomic organization in brain to identify genes associated with alcoholism. \u003cem\u003eTransl Psychiatry\u003c/em\u003e. \u003cb\u003e9\u003c/b\u003e, 89. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1038/s41398-019-0384-y\u003c/span\u003e\u003cspan address=\"10.1038/s41398-019-0384-y\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2019).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eErickson, E. K., Farris, S. P., Blednov, Y. A., Mayfield, R. D. \u0026amp; Harris, R. A. Astrocyte-specific transcriptome responses to chronic ethanol consumption. \u003cem\u003epharmacogenomics J.\u003c/em\u003e \u003cb\u003e18\u003c/b\u003e, 578\u0026ndash;589. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1038/s41397-017-0012-2\u003c/span\u003e\u003cspan address=\"10.1038/s41397-017-0012-2\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2018).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eMcCarthy, G. M., Farris, S. P., Blednov, Y. A., Harris, R. A. \u0026amp; Mayfield, R. D. Microglial-specific transcriptome changes following chronic alcohol consumption. \u003cem\u003eNeuropharmacology\u003c/em\u003e \u003cb\u003e128\u003c/b\u003e, 416\u0026ndash;424. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1016/j.neuropharm.2017.10.035\u003c/span\u003e\u003cspan address=\"10.1016/j.neuropharm.2017.10.035\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2018).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eOsterndorff-Kahanek, E. A. et al. Long-term ethanol exposure: Temporal pattern of microRNA expression and associated mRNA gene networks in mouse brain. \u003cem\u003ePloS one\u003c/em\u003e. \u003cb\u003e13\u003c/b\u003e, e0190841. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1371/journal.pone.0190841\u003c/span\u003e\u003cspan address=\"10.1371/journal.pone.0190841\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2018).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eLiu, C. et al. A DNA methylation biomarker of alcohol consumption. \u003cem\u003eMol. Psychiatry\u003c/em\u003e. \u003cb\u003e23\u003c/b\u003e, 422\u0026ndash;433. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1038/mp.2016.192\u003c/span\u003e\u003cspan address=\"10.1038/mp.2016.192\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2018).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eZheng, Q., Wang, H., Yan, A., Yin, F. \u0026amp; Qiao, X. DNA Methylation in Alcohol Use Disorder. \u003cem\u003eInt. J. Mol. Sci.\u003c/em\u003e \u003cb\u003e24\u003c/b\u003e \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.3390/ijms241210130\u003c/span\u003e\u003cspan address=\"10.3390/ijms241210130\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2023).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003ePark, P. H., Miller, R. \u0026amp; Shukla, S. D. Acetylation of histone H3 at lysine 9 by ethanol in rat hepatocytes. \u003cem\u003eBiochem. Biophys. Res. Commun.\u003c/em\u003e \u003cb\u003e306\u003c/b\u003e, 501\u0026ndash;504 (2003).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eOomizu, S., Boyadjieva, N. \u0026amp; Sarkar, D. K. Ethanol and estradiol modulate alternative splicing of dopamine D2 receptor messenger RNA and abolish the inhibitory action of bromocriptine on prolactin release from the pituitary gland. \u003cem\u003eAlcohol. Clin. Exp. Res.\u003c/em\u003e \u003cb\u003e27\u003c/b\u003e, 975\u0026ndash;980. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1097/01.Alc.0000071743.57855.Be\u003c/span\u003e\u003cspan address=\"10.1097/01.Alc.0000071743.57855.Be\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2003).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eGuo, T. et al. A Novel Functional Splice Variant of AKT3 Defined by Analysis of Alternative Splice Expression in HPV-Positive Oropharyngeal Cancers. \u003cem\u003eCancer Res.\u003c/em\u003e \u003cb\u003e77\u003c/b\u003e, 5248\u0026ndash;5258. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1158/0008-5472.Can-16-3106\u003c/span\u003e\u003cspan address=\"10.1158/0008-5472.Can-16-3106\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2017).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eBejar, R. Splicing Factor Mutations in Cancer. \u003cem\u003eAdv. Exp. Med. Biol.\u003c/em\u003e \u003cb\u003e907\u003c/b\u003e, 215\u0026ndash;228. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1007/978-3-319-29073-7_9\u003c/span\u003e\u003cspan address=\"10.1007/978-3-319-29073-7_9\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2016).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eGaric, A., Berres, M. E. \u0026amp; Smith, S. M. High-throughput transcriptome sequencing identifies candidate genetic modifiers of vulnerability to fetal alcohol spectrum disorders. \u003cem\u003eAlcohol. Clin. Exp. Res.\u003c/em\u003e \u003cb\u003e38\u003c/b\u003e, 1874\u0026ndash;1882. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1111/acer.12457\u003c/span\u003e\u003cspan address=\"10.1111/acer.12457\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2014).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eSariyer, R. et al. Alcohol-Mediated Missplicing of Mcl-1 Pre-mRNA is Involved in Neurotoxicity. \u003cem\u003eAlcohol. Clin. Exp. Res.\u003c/em\u003e \u003cb\u003e41\u003c/b\u003e, 1715\u0026ndash;1724. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1111/acer.13474\u003c/span\u003e\u003cspan address=\"10.1111/acer.13474\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2017).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eDowning, C. et al. Gene expression changes in C57BL/6J and DBA/2J mice following prenatal alcohol exposure. \u003cem\u003eAlcohol. Clin. Exp. Res.\u003c/em\u003e \u003cb\u003e36\u003c/b\u003e, 1519\u0026ndash;1529. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1111/j.1530-0277.2012.01757.x\u003c/span\u003e\u003cspan address=\"10.1111/j.1530-0277.2012.01757.x\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2012).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eLlovet, J. M. \u0026amp; Hernandez-Gea, V. Hepatocellular carcinoma: reasons for phase III failure and novel perspectives on trial design. \u003cem\u003eClin. cancer research: official J. Am. Association Cancer Res.\u003c/em\u003e \u003cb\u003e20\u003c/b\u003e, 2072\u0026ndash;2079. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1158/1078-0432.Ccr-13-0547\u003c/span\u003e\u003cspan address=\"10.1158/1078-0432.Ccr-13-0547\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2014).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eBerasain, C. et al. Impairment of pre-mRNA splicing in liver disease: mechanisms and consequences. \u003cem\u003eWorld J. Gastroenterol.\u003c/em\u003e \u003cb\u003e16\u003c/b\u003e, 3091\u0026ndash;3102. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.3748/wjg.v16.i25.3091\u003c/span\u003e\u003cspan address=\"10.3748/wjg.v16.i25.3091\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2010).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eLi, X. et al. A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation. \u003cem\u003eNat. Cell Biol.\u003c/em\u003e \u003cb\u003e18\u003c/b\u003e, 561\u0026ndash;571. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1038/ncb3338\u003c/span\u003e\u003cspan address=\"10.1038/ncb3338\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2016).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eToki, Y. et al. A selective splicing variant of hepcidin mRNA in hepatocellular carcinoma cell lines. \u003cem\u003eBiochem. Biophys. Res. Commun.\u003c/em\u003e \u003cb\u003e476\u003c/b\u003e, 501\u0026ndash;507. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1016/j.bbrc.2016.05.153\u003c/span\u003e\u003cspan address=\"10.1016/j.bbrc.2016.05.153\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2016).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eChang, J. et al. Genomic analysis of oesophageal squamous-cell carcinoma identifies alcohol drinking-related mutation signature and genomic alterations. \u003cem\u003eNat. Commun.\u003c/em\u003e \u003cb\u003e8\u003c/b\u003e, 15290. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1038/ncomms15290\u003c/span\u003e\u003cspan address=\"10.1038/ncomms15290\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2017).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eLiangpunsakul, S. et al. Effects of Age, Sex, Body Weight, and Quantity of Alcohol Consumption on Occurrence and Severity of Alcoholic Hepatitis. \u003cem\u003eClin. Gastroenterol. hepatology: official Clin. Pract. J. Am. Gastroenterological Association\u003c/em\u003e. \u003cb\u003e14\u003c/b\u003e, 1831\u0026ndash;1838e1833. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1016/j.cgh.2016.05.041\u003c/span\u003e\u003cspan address=\"10.1016/j.cgh.2016.05.041\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2016).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eSozio, M. S., Liangpunsakul, S. \u0026amp; Crabb, D. The role of lipid metabolism in the pathogenesis of alcoholic and nonalcoholic hepatic steatosis. \u003cem\u003eSemin. Liver Dis.\u003c/em\u003e \u003cb\u003e30\u003c/b\u003e, 378\u0026ndash;390. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1055/s-0030-1267538\u003c/span\u003e\u003cspan address=\"10.1055/s-0030-1267538\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2010).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eTholen, J. \u0026amp; Galej, W. P. Structural studies of the spliceosome: Bridging the gaps. \u003cem\u003eCurr. Opin. Struct. Biol.\u003c/em\u003e \u003cb\u003e77\u003c/b\u003e, 102461. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1016/j.sbi.2022.102461\u003c/span\u003e\u003cspan address=\"10.1016/j.sbi.2022.102461\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2022).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eMalakar, P. et al. Long Noncoding RNA MALAT1 Promotes Hepatocellular Carcinoma Development by SRSF1 Upregulation and mTOR Activation. \u003cem\u003eCancer Res.\u003c/em\u003e \u003cb\u003e77\u003c/b\u003e, 1155\u0026ndash;1167. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1158/0008-5472.Can-16-1508\u003c/span\u003e\u003cspan address=\"10.1158/0008-5472.Can-16-1508\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2017).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eKryger, R., Fan, L., Wilce, P. A. \u0026amp; Jaquet, V. MALAT-1, a non protein-coding RNA is upregulated in the cerebellum, hippocampus and brain stem of human alcoholics. \u003cem\u003eAlcohol (Fayetteville N Y)\u003c/em\u003e. \u003cb\u003e46\u003c/b\u003e, 629\u0026ndash;634. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1016/j.alcohol.2012.04.002\u003c/span\u003e\u003cspan address=\"10.1016/j.alcohol.2012.04.002\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2012).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eCardamone, G. et al. Not only cancer: the long non-coding RNA MALAT1 affects the repertoire of alternatively spliced transcripts and circular RNAs in multiple sclerosis. \u003cem\u003eHum. Mol. Genet.\u003c/em\u003e \u003cb\u003e28\u003c/b\u003e, 1414\u0026ndash;1428. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1093/hmg/ddy438\u003c/span\u003e\u003cspan address=\"10.1093/hmg/ddy438\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2019).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eYin, Q. F. et al. Long noncoding RNAs with snoRNA ends. \u003cem\u003eMol. Cell\u003c/em\u003e. \u003cb\u003e48\u003c/b\u003e, 219\u0026ndash;230. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1016/j.molcel.2012.07.033\u003c/span\u003e\u003cspan address=\"10.1016/j.molcel.2012.07.033\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2012).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eRomero-Barrios, N., Legascue, M. F., Benhamed, M., Ariel, F. \u0026amp; Crespi, M. Splicing regulation by long noncoding RNAs. \u003cem\u003eNucleic Acids Res.\u003c/em\u003e \u003cb\u003e46\u003c/b\u003e, 2169\u0026ndash;2184. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1093/nar/gky095\u003c/span\u003e\u003cspan address=\"10.1093/nar/gky095\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2018).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eChen, L. L. The biogenesis and emerging roles of circular RNAs. \u003cem\u003eNat. Rev. Mol. Cell Biol.\u003c/em\u003e \u003cb\u003e17\u003c/b\u003e, 205\u0026ndash;211. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1038/nrm.2015.32\u003c/span\u003e\u003cspan address=\"10.1038/nrm.2015.32\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2016).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eHansen, T. B. et al. Natural RNA circles function as efficient microRNA sponges. \u003cem\u003eNature\u003c/em\u003e \u003cb\u003e495\u003c/b\u003e, 384\u0026ndash;388. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1038/nature11993\u003c/span\u003e\u003cspan address=\"10.1038/nature11993\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2013).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eMathurin, P. et al. Early liver transplantation for severe alcoholic hepatitis. \u003cem\u003eN. Engl. J. Med.\u003c/em\u003e \u003cb\u003e365\u003c/b\u003e, 1790\u0026ndash;1800. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1056/NEJMoa1105703\u003c/span\u003e\u003cspan address=\"10.1056/NEJMoa1105703\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2011).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eIshwaran, H., Rao, J. S. \u0026amp; Kogalur, U. B. BAMarraytrade mark: Java software for Bayesian analysis of variance for microarray data. \u003cem\u003eBMC Bioinform.\u003c/em\u003e \u003cb\u003e7\u003c/b\u003e, 59. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1186/1471-2105-7-59\u003c/span\u003e\u003cspan address=\"10.1186/1471-2105-7-59\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2006).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eThe Gene Ontology Resource. 20 years and still GOing strong. \u003cem\u003eNucleic Acids Res.\u003c/em\u003e \u003cb\u003e47\u003c/b\u003e, D330\u0026ndash;d338. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1093/nar/gky1055\u003c/span\u003e\u003cspan address=\"10.1093/nar/gky1055\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2019).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eAshburner, M. et al. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. \u003cem\u003eNat. Genet.\u003c/em\u003e \u003cb\u003e25\u003c/b\u003e, 25\u0026ndash;29. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1038/75556\u003c/span\u003e\u003cspan address=\"10.1038/75556\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2000).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eAnders, S., Reyes, A. \u0026amp; Huber, W. Detecting differential usage of exons from RNA-seq data. \u003cem\u003eGenome Res.\u003c/em\u003e \u003cb\u003e22\u003c/b\u003e, 2008\u0026ndash;2017. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1101/gr.133744.111\u003c/span\u003e\u003cspan address=\"10.1101/gr.133744.111\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2012).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003ePercie du Sert. Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0. \u003cem\u003ePLoS Biol.\u003c/em\u003e \u003cb\u003e18\u003c/b\u003e, e3000411. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1371/journal.pbio.3000411\u003c/span\u003e\u003cspan address=\"10.1371/journal.pbio.3000411\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2020).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eLivak, K. J. \u0026amp; Schmittgen, T. D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. \u003cem\u003eMethods (San Diego Calif)\u003c/em\u003e. \u003cb\u003e25\u003c/b\u003e, 402\u0026ndash;408. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1006/meth.2001.1262\u003c/span\u003e\u003cspan address=\"10.1006/meth.2001.1262\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2001).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eSubramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. \u003cem\u003eProc. Natl. Acad. Sci. U S A\u003c/em\u003e. \u003cb\u003e102\u003c/b\u003e, 15545\u0026ndash;15550. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1073/pnas.0506580102\u003c/span\u003e\u003cspan address=\"10.1073/pnas.0506580102\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2005).\u003c/span\u003e\u003c/li\u003e\u003cli\u003e\u003cspan\u003eLi, Y. et al. LncRNA ontology: inferring lncRNA functions based on chromatin states and expression patterns. \u003cem\u003eOncotarget\u003c/em\u003e \u003cb\u003e6\u003c/b\u003e, 39793\u0026ndash;39805. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.18632/oncotarget.5794\u003c/span\u003e\u003cspan address=\"10.18632/oncotarget.5794\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2015).\u003c/span\u003e\u003c/li\u003e\u003c/ol\u003e"},{"header":"Tables","content":"\u003cp\u003e\u003cimg src=\"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAwwAAAG6CAYAAAClc8E6AAAQAElEQVR4AeydBYBVRRuG33N3gQWW7u5upENpQdEfFBCwwMAEUZFQVBpUkFBQkEYaAelOBWkUULq7u7b+eWa5uKIoKuouzMLce885k+9889XE8UW4P4eAQyASgbCLEYvmzYgYN25cxPjx468HrucvXR5x6crVyHg3fB4/fCBi5tTJEas3bLvhSUTEsf3bIyZNmhKxZdehiLDwXz2+6Y2wkKsRq75dGDF23PiIU+cv3TReRHhYxKG92yK+nvRVxKhRoyJGjR4dMWnylIgNm7dHXLkaevN0f/JJ2KXzEd8unBPxw7YDEccO7IlYtGRZxNmLV/5kLn8cPTwsNGLX5g0RK9ZsjLgScvvq/3slh4aERBw/djTi4uXLvxftF89OHt4fMWXStIhT527eNxfOnYk4cuhwxMWzpyK+Xbw4Ysf+k7/I43ZdXL5wNmLujEkR7du9HzFr6aq/le35s6cjTp44EREWER7x3aJ5EctWb/pL+V2+dDHikGl7WHj4X0r/pxKFhUVs3/h9xOIV6yJC/lTCW4986eKFiEOHjxhUbj3N5u9XRcxduDwiNOzW0/wqpsEPOjp58lREWNgvsbxw/qylrzAzZjasWRWxfNXGXyW/pRumjPNnz0QcPX4iIszwnZ/WrYpY88PWiJDQv1PxWyo5IvTqlYjvlsyN6Nq5c8SUed9cT3Tx3GnDU6dF7D9yKmL/7u0RS75ZEXH5Jvz3eqI/8ePw3l0R06fNi7h4JeQXqUKuXI5Y+c3SiC3b90SEh/8S719EdBcOgbsQAZ/cn0PAIRCJQMhZDf68tzp06KDXm76sxx6rp1eatVCHjh018MsJOnvpSmS8Gz63/bBSr7/YSIMnzLrhibRlzQI90fgFTVm4Vkb+/ur5b924dOGclswcp2caPanX3nhTB06e/61okfciwrRu2Vy98VZLTZo8WTNnTNeAvh+r8TPPaObSdZFxbsNn2Pkj+rh9Cw2ftlqH923T1Jmzder8b+Pxd4oLD72iJdO+1CeDx+vCpZC/k9Utp929/Ue9276jdh84estpjh7YqSHDRujomYu/mSYiPFQDe7VTr/5DdOnMMc2eOUU/7Tn2m3H/1s2ICG1e9a3avd9F+4+elfe3MpMG9u6oEeO+Upj5N2/6BM1dsvov5Biu2VPGqXWXj2Wq9xfS/7kkRsvV3LFD9MGnQ/TPUEyYpk0cqfe7fyJF3HrdZo7sq1bv99SV8D+R6IbsQ65e1qjhAzR8wte6Ghr689OIcA37tJN69B2g8LCrGj/0U330+difn/+JX2FXL+iLz3pp8PgpCgu9qrXfLdCSlT8oJDT8T+Ty16Ke3LdDndq+p9UbdyoqrZw+vEvNX3xeS7/fpZ3bN2n67Pm6fOX29e6mFfP1YtOWOn0p7BcVv2rwnj93utZv2qK/0W2/yNNdOATuFAScwXCn9KRrx99HIFZSvdOxh4YMHqAXn/yf4saOpdqN3tSQIUP0fouXlSRugFYvW6zhQ4doxMjRWrFuoxEqEfJ8ngkBCr14RguMYjj8y1H6YcsuGYegfF6AAs3zAF/kUDtz4rCmTByvIUOHa8XaH3WjSL5y5ZLGDO+vZm+9q627DikwIJb+WAv0KXO+IurQuYt69uypfp/2UtaEPk2bvkD8Xb54TsuXzNeI4cP15ZcjZWYfFGqk4aVzpzRr6lcaOnSYZs1bpAuXrxJdVy9f0PKlCzR48CBNmDxFx04ZRdS0ITBWgK1K6gzZ9WC1qkoaP452/bheq9as0fQpkzR4yFCt/eEng4nNRju2bNDQIYM1cvRYbdt9wNyPiHwQ5TPECOhvFs81GA/WlBlzdSksQrHjxFZYyAUtmjNFgwYN1tLlq3TpmrJw9uRRzZw6ydR5qCZMnKLDJ87q4tkz2rh+ranzPA0zSvy23Qd1/NAeTf5qvIYNHaqvp83S0ROnbalhRunasHaFwWKYRhvF+NDRY9qwfpXmL16iRYsX6ZRRIM6fPaV5s6eZsgdp+pyFOnvxsi6dP6O1q77Td8uXaNy48ToTFldPPt5AKRLF04Vzp7Vw7gxTpyGaOGWGLeuQUYRmzZur5atW6acDp1Wpag3lzpjcKJwROnJgt6nbOEMDw7TS0JBpsi6avpg/a6rBYaimzpil46fO2PpG/YgIu6Jli+dp8KBB+nr6LJ0x9bpy+aK+XbRQl8IDdE+pcipTrND1JEd3b9Xylau0YO4cDTN9v2zNhutK2ZmTR0zf+3GcrP2Hj+rg7s2aPmuGlny3Ulu271fl6rVVqWwRm9+FMyc03eA+yNDE3EXf6LwpO+ziWa367lutWr1SY0aNMHhO0MHjZ3X21DEtWLxAy5Z9q2Wr1pi4F7Ty24UaPmyoxo7/SnsPHrF5Rv0IuXRey03bhg0dZull45YdZvyEG/r6XqvWrNUMU/bgwUO0ev0mGb+3TYrRNm70cI39aooOHD2l2IGR9GkfXvsIuXpFywztQ4dgdu6aEXrmxBFNnTRBgwYP1oIly4xxekWhF05rpanzylUrNHqkyXfCRB05dV5gNd9g/K159t2a9dq3e5e+X79a48eO0sQZ83X69GnTL/M12GDz1eSpdrxQfIAZL4GxAuVFSAd2b9f4MSNNP4zQtyvX/abye9D01/jRIw0dDdPseQt18fIVnT66W7PmzNXiJUu0be9hsrXhMPRl+nX56tVa9+N2+QIDpbALWjJvuqGr4Vq+er1CQ8NMf4dr/+5tGmfKHjx0hNb/uM3cs1lEfhjD4/CBHZq7cKGWLlmsLXuOqGCJirqvZGGdNmPo22+/05L5s03fDdey7zfr+JH9mjB6hEZN+FpHT5+zeYSFXNG6VcsM7Q42NDDe0NJvG8Z7tv+kUSOGCf64cctOhYWF6pu5M3X41AUVLl5S5UpF0hqZeoZdBsY2vM9cZM6WTw9Uq6KzBoulSxfrYki4uSuFXj6nOfMX274/tG/XtTYO0ypDI1dN28OvXDDGz7f65pvF+nL0eO2Igp8v0Gf4TIC+N+MZvrhg6Xe6GhKqWLGDVKHi/SqQO4c8TzpnxkkknQzRNyvWWOzOnjym9evW6tulS0xfDdHMeYt05vxFW6fzp49r1rRJBoshmrNgqS5cuWJ40wpt373f8r8Ig/e+nTu0du0mY5CF2TTuwyEQUxAwwzKmVNXV0yHwDyPgi6WcufOp2D1FlC1zWgUE+JQucw5zfY9yZc+kcf0/0IO16+qtt9/RW280V70GT2j6sp/k+Yyi4nkaO7CnXmj2ulq83lTPNG6itZv3K44Rep48+UyckItH9NrTT+q5F19R65YtVPvROho4cYERJLr+d/XKZa3f8IPyFyqvcgVyKiw05Pqz3/sRauKFhoQoxAi9kydP6nxYgLJkz6iQK5c0/IteeuX1Npq7YIlGDOmn5mbW4vsft+rDdm30TqfummcUglbNX9TbH36hUKPATxpk4rzeUvMWL1afDzupxTvddeT0ZflMG30BPu3Zuk6DR4zWqXOXNGdsXz3WoL56fzZAw0y6p59opO82bNW6hTP0ZIOnNXLSdI0ZOUQvvPyGNm27UVGM0IiendX09Xc0a+Z0vdPiFb3V+VNduBqmb2eNVZ/PBmrSxPF6temrWoDRcP6Ymr70tNp37a158+bpvXfe1Gtvt9ehg7vU7f039OSLTfXZgC80d/4cvdasqbp/MkTffLtI7d5tqS59B+u8mSH6bvo4PffMC5owabI+/ai9nnjuJS385ludOHxQc+fM1/Ez5zTQtLnNu52N0rvIGIrN1a3nUB0+uF+d3myiBs+/pH4Dh2vJ4vnq3O0jHT55ThNHfqH3On2oRUuXqtt7b6lFu+7asHGTDu4/qR3bt2qeqc+IIV9ozdYjRgE8qJYvv2LwGqjZU8ep0VMNNW7afA3/vLfeaf+Bvvlmkbq+11LvmTZiqPj7PCzkkvp2fU/PGRxnzJmtDzu21auvd9ZRY8yt3bBOBw7s05yZ83TumtFHup++m6Y6jzyi97v00PSvJ6lxvXoaN32JTh7dr/fffkNtOvbU4iXf6OMP2uv9bh9r00/fa++eQ9q48UdjVG7VxGF9NerrhTp3/JC6t22pt039Fi1ZpHdbv6VPBk7W1TP79F6Ll9TIYPLl2PFq905rNXvrPe0/dMB4hXfp8N4dmr/oW+OdH6s2bdtp4eJFGtCns159rZW27z9KFW24eumcvujbTS+91kLzDc2NGPqZXnqrjXYZw2LxpC/0WP3H1Ktff40Y2l+NnnxK3xpD+/DezQa7p/RB74Eaa4yGoZNnGvr8tTgb8+kHevm11pphZt7ebfma3mj3kfbv2a733mimdt16a6Hpm7eavaY+X0zSlRM71ar583Z8jho7wbbzzXc668Chg9q9c5cOmL5c9M0KLZv/tRo986Te79RVI8ZMUs+uHfVGi3c0f+EC9ej4rpq36Kx9h0/btvk8n07s36a2b7fWwNGTjCE6VS+9+JLGTl+k0LBwG8dYkdqy/lvVq9/A4DpWs2dN05vNXlT/MVOMwnpI27ft0CZjoGzavvdafOnA3h3au/eYwXmbvl2zQbF8oVo6c6Te+6CPUcoH65WmzbT8x506eXCH3mjyvAYM+VIzJo9Ro/pPadr8NVF4ToSO7N9taPWAfli9Qqu//1GLZk/SzKVrtG7pND1ev55at+usYf376fGGT+oZM3YGDx+tru3eMc6VAQo3fGfhpNFq9kozozgv0PD+fdSs+bvGQRBlrBslef23c1X/0YYa8OU4jTf99UyjVzRn6TotW7FU+44c0vKly3T6/OXr7eOHZz4CDL/58fvlFufDe37Sm2+01LLvd5on0g9Lv7Z0tea7FWrd9FV9OuhLzZk1XU0NH5ixcLXCLx1Tl3eb66nnX1DPTz/XRmME24TmIyAgQBdO7NIbrd/VlMkT9cbLZlwPm2mcJRf11eihWr5uky6eOaxmzzVSl+59NHv6JDVp9Lh6fjFVB3ZtVOvmTdSkWRvjZFiqdmY8fPrFaF28eEW9O7VStx59tHDeDDVr8rjafTxIU74ao579hum8eY4zZvTQTzTGOHOuGqPGVMX9v0sQuBOa+WsOeye0yrXBIfB3EIiIMJ4khLn/22QWflVnL/lUxXjWBwwbpWbP19UJI8AWLVphzAHz3LgRk6bOqn5fDFHbN17U3h+Xa/DoCQoNCJLPjDIjnzRteG+NmrdMDzd8SV8O+VxJwo/q4y6djfJ0ymQQ+T9evAR6p92H+uKTLkqXNKER7NQj8tlvf3omf5+2r1upR2vVUuXKlfVQrXrasP+8KlYopatXr+rMmYtqZhTrPn16qu+nfeWdO6I1a1drxsIlKl6ppvr06av277+rdImCdPrYXg0ZN1n1nn1Dn/b6RIP79daudQu06Lu1kjEYzIdCjFFx6vRZhRmF5+L5U8qQvaj6DRiqqeNGKdHVw5q94Bv1HzJUKfOW18Qvh6hvzx5KrqMaYIyMcP38d2r/RnXrO0SPv9hS6SkMHQAAEABJREFUX47+Sj27tNbeLT/q4MFjSpu5sPoNGq3RX36pUlmSa+nqbTq6f498cZKoU6+++uyzfmrV+BGtX7ZE249c1OEjJ1X3uTaaM3umSuXLpESps5vZlIH6uPvHatq4nlYvX6uLF06pxye9lf/eWho+YoxGDeuvBLF8yleohIqWLqtuH30g79APmjB7id40BkM/g1Xvbq21eNZErfj+J+3YcUzVaj2viRPGquI9OXTs6AldNbNK69etUb7i96pzp64aPLCf8mVJqUKlKqpsmYKqUr2mXq7/oCnb4KVYWj7rS207FaoevQdojPGM165aSpvWrrTeyKKVH9KHH3ZXr97dlTNzOoWbWSA/Wtu//1ZdPxutJq931oSx49Sz8/taOrmfZn+/zyhxL6p8+Yrq1aez0iSO70+iK6ZuV31x1LJ9V40d9aXqV8inD3v10869hxQ7QSr1GThEn/T+2CjJL2qbMVIzFKqi6lXLqG7dR1S3ZkWdNDMFZ40St37tck1b/qNRugapb68+avmiUTonfakdh07o3NmzqlrraY0bP0k9W72oNUtn61hEWlWrXl1F77tfbZo9p23fr1KyjHn1nlE8hw8dovKlChhFM/R6PS9fuqDDp66qaduu+uyTPur07ju6cuCAduzcpyuXzyld1oL65PMhmjZhjJKFHdfClRs1Y+JobT/qGUXyaw3p/5mqly+mEIOXdz1X6dzhn9T1k4F67Lk3LX198kFbHdyxRV9PHKvvthxV3/7DNGzYcL3xwmP6asJQbdx3TOfPndMD9Zpo/FeT1bnZU1q+YKbOxcmsymbcl6r2kFq/2kixws6ZcZ3ClD1JvVs31Oz5iw0Nt9LQISM06PM+2rZurqnjGgX4PHlm8B89tEs/7NirV5q3UI+PDX6vPK1EcX0/r24y/Obgvj3KXuRejTJt/PzTPnqoXGHNmLtMaXMU18MP11CdJ59TrUolrreuaJkquq98EVOvGsYJ8YgCwsOUIm0+DRo+TiMH91f6uJ7xiG/Q1BF9dTJWKn3c53Oh6N9fLK0Gmlmcw/5ljl6AChQrpzJlS6vBc6+oYc17deXcCZ09f0mXjSF31Rjv7330mUYZJTfZ1YO6miyXxn09Vc0bPaqFCxaZ/j9m+NwYlan5lPr2/kSffzFAFw9vMrzlG4UwdWZqfPHcSY0wdYqT4R4zdibry2GDVTRbPHUbNE5NjbOgQsmSRvFvqaypk5rYv/7PLNqJ4yeUtWg5JY51RUsWzldI6BUNGTZOqTPm1O4fl+ng1fgaOvAL9e3TR7Xuy6shI8fp7IULOn36lCre30AzpkxQlTKFrmceER4uz+D+esdeGjt6lJ6pW1X9+nyo06a9Fy+cU8ili5o9fqBmrT2o7n0GG/qeoFcaPKieH7bV+i27df5SqF5t216Dv+ivNi8/rbnGIP1p61bNmTNdFWrUVq9Pv1C39q2VMlGwcubKrw0rv9ExwzPPnjqub5atU+HCBRQUJ/b1+rgfDoGYgIAvJlTS1dEh8M8j8AclGMWr0oM1lS9bJk0ZM1yzF61UiFGYI4xQkvGgEarUaqCqFe7Vgw8+qNxZ02nztt06ceaKUeiN4uCFat3yTfKMmnBo7xbNMkpGYIBP548d1MEjh68XHhAYqJQpUyvAxAszQu36g9/5EWEEX8Zc+dSuY0d1797dKIG9VDpLInXr8qEuKVDVqtbQiR3r9IExTjp3+kBHjHLmC0qm+rX/p/WLpumpp5/Rqk17VL5cMV08vluHT57Qd0vnqFvXzupnhHKAUW6Onzr3cw08z7TJsA5PMkUrZ/7iSpE8hRImT6p8eTPqxIEDOnj0mI4Z46Nb1y76ZMBgnb4cohOnTulyuK7/7f9phcKC06hk8RKKFSBVfOgJff5xB6VPk1S5C92jNEnjK06cWMqVI4NCjOc8WersqlPzAaN0j1O7du00btoShZv2Xb4cqjjxkqrGfaWUMDi+sufIr6plixhFsp86dOis0V/NknGEKuLsHh0xilLJshWUKDiOMuUtrc8/+1QFcmdTaGioaVOEDu7bpSOHjwuPYufOnfXVvKVSnECjGJ1UeOzYqlzhPiVNGE8BvgAT31NAnGCVKn2vtq5aqGcbN9aQCQt0zz3FFRwUqHBDF/SNzJ/PxI9lGrnxhx+UPXs+EzKYuwFq0/4jvfZSIz1U835tWjpdjz9hlO/py1SgYH7FM203kcz/CO3dvEXBKbOq2gNVzbVU5J57zAxUBq1Zv12hRskxPWEoxj66/nH1ylXlMcZQ8aKF5MWJrwceraX9P/1g2pFQ1Q2dLp48XB3ad9DQYRN09mKYLl02uXgmmE6NMLl4nk+BgQE6e3yvzhgFavLogerUpatmLlmuwFih2nv4jBImTqzChUsoXuwAFSiQTUmMgnTl0lXJ9AxtD4wVW2XuraALR7bpuWeeUafeI5QjbyGlSpbIxIn8Hy84sWrXqKFT29eY/uqoT/oN0r6Dp3TlaqgiDK3lyF9CKVOkUvykSVQgf2ZdPHtRP27aqwLFyylv5iRKnCqVKpYvrADqHpml/TyweZWuBqVQyRIlFTtQKl+jvj7v0UHemVPKUrCUcmVNrYDA2CppFNa0CWNp667jSpIsuQoVKqYgY0gWLphdCeLHNYrzVUPnEYowbZL59OQpv2lz5vRpdM7QeoKkaVSseGHFCvQpY858Kl84mw4cMePF8wnFNFX67CpbOK+6v99KL77SXEcuBihPrhymvp6tp0y8AkYZrlwst/r36KT3jWG1ZOUGYyyFXSsxXBGGliIjX/u0fUSNIsyzCF2NiKX8xcoqW5pECk6cRGlSJjF0EaKNG9bp+NF9GjLoM0HPh4yi64Vc1KWLF65lZFpEXiaEX+M3GDk+z7P5JkqZWUXyZFOiRAmUNl0KlSlfTcGmrxObfk5oxtClM0fMeDmsjeuWqftHXdWn7xcKCwjX6bPn5J9BuXjurLbvO6mH6z6spAliKVHytKpUvqwO/fSTLhoaNQWZdkboZn+mKpJxyCginp6uU0Mb1q3V96uXaeX3O1S7YSOdPLRXJ04c1qfG2Pywew9tNAbxxYvnFWpmXOPGja+iJcsZekui+EGx5P+jrSnNOHykcnH54sRT2ZIljCF4SpuPXFXsWIHWYNi4fLVyl66i/PmzS77YqlOrptIGh2nz9kNKl7Ogqhge4wuMpVyGV4UYw/n81XDVa9BYc78eq6caPat1uy6qkuGpxYsXU9KgEC1Y+ZO2rV6skLipVChvTtP/cn8OgRiFgC9G1dZV1iHwHyFw6eQBdWjzpvoOnqBMuYuqfOl7FNsIFl/cuEaFoFKe8cietL+vGEF1JSTUKFGxrRJhbxp56DPKF8I4Wep0ypMnnx6o20jPP/+s0qdKSga/CEZ+/+Kai6uXL+rkSaNIXVvPzz0j7o28jTBCOJWZXaiiGkbxeqRufT1sPMWrVn2n3bt3adCn3bVx6z7lLVBEDz5wv5IGx1ZoaIRq1Kqr9h066OHqFbVj3WK1eKejdhwPNUpSAhUpWkJVqlTV/fdX0xOPP6ViRmj+Vp1kpLnnCzRV8UyIkBcg0cYAowTlyJFPlU0eVapUUYOGT6r2/ffpZ5EtxYodVxFhV81MRYj4C7lwRsuMMnryzAWBFfcI4QbA2HHiaPPq+WrfsZsuRQSp3L0VVa5YgZ+FbkBsRRgPc0R4qNYvm6W+nw9W7PjJVKpseZUqVlQ+mfoFBEmep7DQy4r8C9P675Zr78HD8gICFMvzFOjzKThBIpUqVUZVzGxN1cr365knGiqX8fhHmDbJ5BSZVvIkhYSE6Z4yFfT2u++q3qMP6+LRrWrfvqPWbj0oz/PkCwiQ/y/C/IgdK7YxJEIVbupqLnV092at37jdzEhUUbt276te7Zo6c+AntWrbUbsPHSeKDbGMARIackUYAdwICQvVOUMHsQwNyuBD3lFsMaKY8mWUpjCFhdlLXTRKlBc7SHu2rNenvXvpYmigipUso3vLlFA8Y8zIdHCECYE+z7SS1plczX+uEiVMpnLlKxiaqKIHH3pYTzV8QplTJJCxmQV24s8kMUltuSYb+XwB8kzIma+o3mrVRo2fqK9EgZfU4f12WrjiB4ojlY4f3KVPenbXxh2HVaBQUVWudJ9SJA6WyS4yXMcwwuQpEzwz9jxdNUaMzcB8hIZAJeaH/7/5DjT0pfAQ0/6r5spgcemsln2zTKcvXTK4XFY4lTRPLhtj8UpomAIDfeZKts4yf54vQlTA82T+TNkBgeZb8jxPni9Q5lO+OAEm/xCTXyQN06/nL18xdZT9izCKfpz4ifXksy+qdcs3VL5EAc2d/KV6fP6lWCJHpPCwEM2aOEx9B45QstSZdF+FisqXPavJX/aPagZcK9veMB8Rps/DjYIfYPD1zLWpkCLpUwbXn+vt8wKVPkMWVapUyfRdVdV86BE9YhTfJAnjK+qfSaHAWJGj0+bHQwoODCJDRZiywg3NBphxFvnI1IDnCjDjOEj5CxRVpcpVVK1aNTWo/6TuLV5QgVhwJrLP5xPQXrp4SZF/EbpkaDnc1F0UbG7arMz3Tf9fi1e2Rh2FndppZku+VETiTHro3rymbhHGmMko2ljZ1OHh/z2iJx59yPDfWCZ7T57B7lryX2QfZmgGPsjNy1euKDzcM2kCRF18pu6x48fWVWNYRZh2E+f8lcu6bMZ7LDNWwgx/v3ZboWYshkErvgDdV6OuWH72ULV7tXnlTL3WvI2uxkupEoVyadb0iRo4bqby3VNSWTOmIksXHAIxCoFIDhmjquwq6xD4FxC4JmEQHpR26dQxu7b7qowATpNKRw/u19WrIUYfuSTP88mIJc0YM0jtenyqAf0/0087D6pY0YJKmiDQCJQIhUcEqkyVsgozysnZM2cVOzBMUyZP0pxvVhiBG4cifh2u1cH/YOGU4XrSzAbMXrLOf+v696njR7VmzRqtXLlSM6dP1YhJs5Upa14jAONow4+bVcQotY88/IAunz2hPUfO6szB3Xr1+ee1aP1e1a7bQJWKFdGBHXsVnDyTksePpUMnTqlQ4SJKFDtMXw4bpr1Hj8uzXr7ISkVE/PwdYZQif0UijAYZnCSVMqVNZbzAG5Q2czZlSZNcUyd/pe82blOAzx9TSp+npBKEHNPXX4/Xvn37NfzzbmrdpbeOn70sn7yfI5qyAgIDtGPrBu06dlLV//eoShUtoPXG637u4hUbN1KomzoZg+Hgvu06HR5Xj9arq7L35NO+vdt08eplKV4G5UibVNOnjteWnXu1dMaXavZma+06cEJXz58VG0KTZ8yh4PgROnHhqu4pXlxXj+7U6HFjdNR4talQZDn2l1VGQi6eUd/unTV7+U96uE5D1alRVSHnTunsucvGAAkQ7dplFP/w8HCFGI95IePt3vTDMi1culz7Tb3eafm6hn45Su3fa6s5q7bqf3Ua6IGKFXT+8ElduBSphMpgkS1fYcU+u1eDB0mInwsAABAASURBVH9u8jxgaGeilm89paplC8oXy1OEyV83/MUJiqvNa77VjBkztH3zD/r8i4EqWq68vKvntPfIaT1Yq46qVSijI0eP6ISpr+d58owWtHPPAR0wOJsrhZn+TJYmu66ePaZTIZ6K31NUp/Zv16ixExVqrIMIEz/C9I+/aPvTdINxGevY/n3avH2H+n/ysaHHuapQ/SE1ePRRBVy8rJMnzxn8IlOdPX1UW/YfUpGyVVSn9gMKv3xGxw39GXPDRIgwbYuQPzI4+ozSWqpMMf2wco4mzP1GWzZ+r69nfiOj75n4P/9Pl7u4Eoef1hRDX3sNfY364iO907mXEmfIpl3fL9Wcxct17PAh8/xrnQ2JpULZUppZjTD520PbbLkRBt8w6fCu3dp54KiMnin7zBSV3HipfZeOa+q0qQbH4/pm/jQt+2GncmdMbozhcHlGifxp1RK1bddRSpBOjcwsS2FjfB47fNRia7IQBsOPGzYqPE4y1W9QX7nM7OQO81y6NgqMMbNn504dOX2e6DZ45jPQC7S0sOPgMVsff73NI/E7PMxTqXJldeDAXgUlTG692ounj9esxctknOFEiwyeZ/hYqKGRLTp8+pxMrWXbbZ4yng36kdemc/3tNr2iMDNtFz9xGqVLmVj7jxxS7nwFlcYYeuNGfqnNu/aZ1NRSip8oqQrmyaxxIwdr7aYd2vLDKk2aPE0lypRS/CBjQP8G7ZrEoixTpCKDrYVSmr7LnSmlhpuZz+qPNlDy4CBlz5lDhw/tU7xkqVWkYB6tXzpXs5Ysizwxy/AmsNANfz6fT8f3/KgBwydr754dGjd1iuKlyao8yQMVEhKiwKB4KnlvJW1fMU3TZ8/Vvj271OfzgbrgS6KieTPq4LZNGjN2sg4eOKCZU8YpcZrUShYnVC8ao/j7PSf1aJ3HVLlEYW3fstPwHp+q1rhfa2ZPMPVaq6rV7ldcY3TcUCV3+TsIuEfRAwFf9KiGq4VDIDoh4CkwThylSJFSceLEshVLnCGnnnuusXyXj6t1i+bauPOUUqdJqyNHDupyeICSJE9qlNM8Gt69k0ZNXqwKjzTW0/UfkhcRqoTJkgqF9/46z+m95xtqzfwperPl+7rsS6gXnm+idKkS2zKifnjGCIkbP75SJE+uAJ9nHx3ev1sbf9ykfUaZszfsh6fYQUE6f3CHmjzbWHXq1LHLHsLjp1GPTq2UJV0qVaxUQYM++VD16tbRuJmLlDVXFgUlTqLnGtbTV592NMKtrvp9NVfPvdBU9+TPqWavN9W6BRNs/CYvvqG8pWuoQsnCCooXX3HixTZtCVTc+PHkC/AptplhCYoXJHkyf555Hk/ByZLp9dYtlCXeSdWuXUtPNnpBF7yUavRoTaMCmWjX/genzK7evbto5awxqlu3rroPnqn333tbhXJnVUCcQNk8Tb6U4TMevxJVa6tEzgxq1qSRUbyaKFbSNEqSJL7OnD6ieImCFWDcmJ5RJguWqKQk3mmDx9Nq/MKrOnwuXCmCr+pcaLje6dhFvhNb9WSDx/RM806q/XgjPfZQdWVMFEdvvtpce0NTq+mrz+qrQR+r7qOPqGXH/qpkyi2aN7viJgw2xl2A+PMFBhpFiLamUrXqD2jxV0P1WL1H1bLzx8ILWrpgDuHt3LBsobr0HKrwwNgmWYhKVKuvh+8tpM5vv27wracDYSn0+mtvqEnDWprcv4cefeRRdeszSLUbNlD2DClNmsj/6XMU1acft9OiCZ+prjGEOvYaoiatO6la8ZzyGY0qbrx4CjCKX2TsyM8Icx0eK1yfdO9qFNGntCc8nbq1a6mSJUsrd5aUavZKEz31dCNt3n9EiRIH6ezpE6pivNsLp07VkKETFS9xItPnRpEuUUZNmzymHu+/rkcfraM+X4zTQ8Y4ypEmiWKbcmPFDrQFegaTeMHx5TP9UDh/LoUe36k32nZXkVJVtHf1QjUw9X6p2evKU6qCKpW7R9fIWmky5VbVcsXU37SvfoPHNX7WMqXLmFgHTxyTKUBx48WR56MIT3HMmIgdN1CVajdU45pl1erFRmrycjNtO3jIzIwFyaef/+Imzaxefbpo3fyvDNZ11aX/ZLV6u5WefPJJPf1oRbV761WDy+OaMH+1Xm3eXBlTJrD5+9vjixVb8RPEV4AxVovmz6MLZubnjXd76OiFCAUnjCd5npKmyKIWzV/SN9OGq/5j9fR62256+KmXVb7UPQoIiqN4CYKUr2gplciWRm++/Jzqm5m2RZsPGfp7VAnjB4m/gMA4eqD2o7py5EfTt/XUum17BSdNpnNnDuhiqE8F8+XSd3O+0mfDpxtlnhSS5wtUtapV9OPKb9Sp2xe6Yq7jJ4gr/jzPUxDj0/RD1QavqFzelGrZ9Dk9Uru2vt16Sc88+bhSJgkmqg2xghKoVOE8Wj17vLp/Nl4hviCTPo4C48RRcOJg00xPCgwwbQlW7Gv8MFacuGYmLp7iJEyql197Tcc2L1PD+nX1zLNNlCRLCd1/XxnFCjDpTAlx4iVUk6ZvqEiaMD1u4jRq0lSXgjOr3ZvPmjg+xYkXT4Gmribq9f+eL0DBSRIqduwAM+Zim7LjyTMEExQ3WOXLlVOuvEX0QJVyCogVRzXqPKUq92TSK8831mP1H9f8VXv1xCOPKEHcIMUNTmDSR9Ln9czNj4DYcZQ2fTrNHtFN9eo11MqtJ/XRB50VaMqIFS+uIgJiq0z1Bmrx7IPq9k4z1atbT3PWHlaPzz5XxtRJFBDkaeTAvnqs4eMaN2+9nm/SRHnyFdSLzz+lkb27qU4dw8+GztCb77ynnOmSK1+Be1QiS1KlylZUJQxvMFVw/x0CMQ4BX4yrsatwNETgDqtSQBzdX/dFzZw9T8/VLmMb54sdrBffeFcL583R7NmzNHHSV1owf766tG2qIiXLa8SEmRo9ZqwWLlmkOXNma1DvrsqSOrFyl3xA82ZMUv0aJRUYN7Fad++juQvma+asWZo7a4qefLSqAm0Jv/yIkzSlOvQbqkkTJyhrysT2Ya1Gb5g009WwZnl7bT98ASpVqZa+njpTs0yeM2fO1Nz58zRm1FCVLpLfCMyEeuP9DzVs4Od65/32GjBwiEYPG6SGte/XY6+8qRmzp6trl876cswYtWzeUL6AWGZavY7xnk1Q504dNXTcV+r67utKkz6bOvUZrlfrlFX+klX1cdf3lSZZAj3+2gd655UGShDHk2Il0tsfDNQLdSsro1Fw+w+foKEDPlPvz/pr+JBPlD9Het34d+8DTxpv9Vj16NFdU6bN0NP1aqpmg+f1/uvPKYFRFGPFCdYTL7fRq088qEzZC2romAn6vHd3dev+sT7v/4Wmjh+hB6pVUq9PPlHR3JlltArlKVpWw0eMVNeO7dW5W3eNGDlKg/t/onTJEyt7oTIaOHykevfqrnETJqv9228qc7bs+rhvf00YPVj3ZE+t2g2aaOzo0WrfvoMmTJui119+Whmz5NG4SV+raomc4i9nkQqaMnmcspo+rlyzjsaOH6P2772ngcPGqF2rV5QscTxVf6yJFsyZoQ86t9NHH/fRg6WyifX6rTr11GDTHx/1/tx6XYsVyqEajzXSjJlT1alTO/UfNlzvtHjetl/X/rzAWKpc53lNmzFLHxusxo6boPebPq04gT4Vvq+6PuzWUakTJ7gWO/Lr6uULypCtmHp9OsCeHjXR0ETBbOmUIXte9fp8qPr16Kq2Hbroi0FDNWF4fxXNlV7V67+sOTMn6dkG/1Prrp+rw+tPGeUxsRq91MLMEhm8OnTUqPHjjCf1fwpKmVOfDRqtmuXy2gJT562gEcOHqVTu1CpdqaamTZ2u7u1aqGat/2mYoa8PunZU7wFD1av7+8qcNplNw0eCJKnU4r1uGjl4gN5q9bb6f2H6dcpE/a9qedV94T292/QJJQjySQEJjEE2QC/Xr6748RPrnW69NNHg3qPXp5oyY44+eru5YpFhlFCmWgONGjPO0tfXU2fo2ccfUYJEKfTim+9r4oQxYt/PuDGjVbfGvYqXpoAGDh2taiVz2BwyFK2hkcMGq0i2pLqvem1Nmz5DXd9uqseebKIOpo/ZBxNgjIqqjzyp0aaMDh06aPzEr/V2s+fMzGJcPfZiWw3u016JU6ZR687dNWbEQL37XnuNHDlCD1Utq4AA0yZTEspx2WqP6OspU9WtfVt17dFbQ4Z+qbH9PzRGRVw9VO9ZTTVYvvhYVXkmvv3v+VT10We1YN4MtX3jOTUzDogurZ63j4ISJNXbnbrrhfrVTFtTqWvvgRo8oL8+6NVX06aMUZWyhRRZso1uhkxs1X+2mWbMmq1mjevouVdb6uUGNVTpkec0fkQ/JUsQR3GSZdHH/UfpmYeL2USVaz2hUYN6KDAgQEXLVNOIUeP0Udeu+mzYSPXt2V5Z06ew8fwfabLm16dfjDZ8qK8Zq301fHA/5UifUsmy5VG3nr1UJFdWf1T7nSxdTo2ZOEWV78mh8lVq6cOObytRgnjyBQSqyiNPaPLkMWa8Z7Rxk6fJqHe79tHoIQPUocsHGvfVSN1f4R4FJMygnv1Hqm6Voj/jZlNIRco/oElfT9Po0aPUs2cvjf5yuCqY2ch4CRKpTXvjXKlZQXESJNbr7XppjInTo/cnmjltgv5XLr9CQy4rOFkW9eo3QN0/6GryGKmHq5RXgM+nBq+01FeTxhm+000TzaxT8yZ15POu6tChAzp2KUKPPfG4oJtr1XBfDoEYhUBUvhGjKu4q6xD45xDwlDBxcuXImVPJE8e/XkysoPjKW7CwihQqoNSpUylbjhzKlCGNgoODlTlLNiU3swGZc+RW4cIFlSJpIiuk4gYnVo7s2ZQ0YXx7HStusHLnza9i9xRV1kzp7L3rBUT54QUGKk3GTMqeLZtiBwbYJ4mSplROU2YSk5e9YT884wVNZOqSU/ny5bMhZ47sSpo4gTwvUr0ITphYhe8prjKlSyl1yuRKlSq1UiRLIi8gUNlz51PZsmWVP3eO6+X4jNGQPnM2lStfXkULF1DC4LiSL5bSps+sFAaPuMZjmD5tausdTJoyrVInT2KEoqmMF6DU6TIZzBLKM5eJk6VSyVKlVapkcaUycTxumvtR//sCApQpay5bh9zZM8vzPAUnSq40KZMpwHj7PJ9PSZOnVkqDp888S5E2g0qVLmP6IL+C4ydQlsyZlTRJUqVPl17xgmLbrD1foMEui8qWK2frn8LMeGTIkFFxYwWa/H1KaRSM0qXLqkjBfAqKbe6Z+KnSZhT9liRhkGLFDlL2XHlV3rS/QN6cihsnUIHmXpYsWa8r8UHxgpU1SxYFxQowz+IoS45cFq8ihfIrQfwgW4/YceIbr2N+5cqVXRnSZ1Ci+HHs/XjxE6pg4WIqW6qkUqdIZu/5AmMrS848KleuvAoXyKvgeJF52IdRPjJmyaUyZcoof54cinWNLuIlSKi0adOY/giIElOmHfGULGkyZctFExU0AAAQAElEQVSVR8WLF1faFEmuPfeUPHValSxTTiWKFRX4ZMyQQcHGKx0rKFh58uVX+vRplNpgnSZlUpuG9ufKW0Dl7y2vPKY9QXFiyQsMUoZMmU27IusaaDzVmTNlUvygQINJXINhbuXPm0NxDH5pM2ZRmbLlVPyeIoI2baZRPoITJVWRYiVUtkwppU+TypadImkSJU1h6pEiqayz2vMplemnFMbz7Jm0scxYKlS0mB1LmTNnVdrUKcR98+j6f19AgDJmzSFoPE+OrPJdixDbtDNfgcIqX66ssmfOYGnfFzuuMpr2JIwX2U+x4yZU5kwZFc/QSKw48ZQjV27lzZ1dyc3MYxozjgJ8PltOgOm7TNlyqXz5ciqQN5dpf2x7P4mh20zp0ohY8RMmFnUtZ8rLZsqLFchdG81+eAGBymx4R1nT//ny5FRS0285smUxfepTXEMvufLkU+YMqX7RvsDY8ZXH8JLs2TMpVeq0SmvGDJn5DD2nTpNO4MR1cMIkKmLGfyS2Kbj1qxA3fiLlyZtP2bOmV/KUqZU8SUJjbCRTlkwZFGhA8xmPe/oMmZU8UTybNoHpr8wZ04lWeL4ApTLjvowZbzfrXxIFJ06hEmZ2q2TxYkplxrMZzmKmIl369NfHLvEIgbHiKPO18RacILHSGZoI8FGaFDdeAmVIl9b2GXEJ8U0ceFy5smUETw40BONR54yZlSRBZJ2J5w/xghMpY8aMypA1p0qXKa3MGUw/0U6faYvBLkmihBbrwFhxla9gUcs7M5u+lPkLCIilRIkSK5OpH/wtR5aMZiz6zBMJWshpxgn0lt/QSqyAcK1fuURvvf2+YqUppPrGEImMaaO7D4dAjELA0W6M6i5XWYeAQ8AhcGsIFK70mDq1aaoUwd6tJXCxHAIOgT9AwFOmnMXUonlTZUgW/AdxzWNj5KbLkFUNHn9Gn/b+QJlSJjQ3/93/rjSHwO1CwBkMtwtJl49DwCHgEIhGCKTMlEvlShU1HnLH5qNRt7iqxGgEPCVMlkrFzMxcwnixb6ElntJnzqG6j9VVzizpxazKLSRyURwC0RIBJ0n+825xFXAIOAQcAg4Bh4BDwCHgEHAIRF8EnMEQffvG1cwh4BCIaQi4+joEHAIOAYeAQ+AORMAZDHdgp7omOQQcAg4Bh4BDwCHw9xBwqR0CDoGfEXAGw89YuF8OAYeAQ8Ah4BBwCDgEHAIOAYfADQjEcIPhhta4S4eAQ8Ah4BBwCDgEHAIOAYeAQ+C2IuAMhtsKp8vMIeAQ+MsIuIQOAYeAQ8Ah4BBwCERLBJzBEC27xVXKIeAQcAg4BBwCMRcBV3OHgEPgzkLAGQx3Vn+61jgEHAIOAYeAQ8Ah4BBwCDgEbhcCNh9nMFgY3IdDwCHgEHAIOAQcAg4Bh4BDwCHwWwg4g+G3UHH3HAIxDQFXX4eAQ8Ah4BBwCDgEHAL/EALOYPiHgHXZOgQcAg4Bh4BD4K8g4NI4BBwCDoHohoAzGKJbj7j6OAQcAg4Bh4BDwCHgEHAI3AkI3DFtcAbDHdOVriEOAYeAQ8Ah4BBwCDgEHAIOgduPgDMYbj+mLseYhoCrr0PAIeAQcAg4BBwCDgGHwE0RcAbDTaFxDxwCDgGHgEMgpiHg6usQcAg4BBwCtx8BZzDcfkxdjg4Bh4BDwCHgEHAIOAQcAn8PAZc6GiHgDIZo1BmuKg4Bh4BDwCHgEHAIOAQcAg6B6IaAMxiiW4/EtPq4+joEHAIOAYeAQ8Ah4BBwCNzRCDiD4Y7uXtc4h4BDwCFw6wi4mA4Bh4BDwCHgEPgtBJzB8FuouHsOAYeAQ8Ah4BBwCDgEYi4CruYOgduKgDMYbiucLjOHgEPAIeAQcAg4BBwCDgGHwJ2FgDMY/sv+dGU7BBwCDgGHgEPAIeAQcAg4BKI5As5giOYd5KrnEHAIxAwEXC0dAg6BuxuB8PBwnT59WseOHdPFixejDRhXr17V5cuXf1GfkJAQW8ewsDB7PyIiQpcuXRJx+W1v3kEftOnChQvyt5emcY82R7135coVEXhGHAJ9efToUZ06dUr0MfeIQ37+a+6Rhrg84zf3wJPA75genMEQ03vQ1d8h4BBwCDgEHAIOgduJwJ/OC0WxW7duKlasmLJmy6aHH35Yc+fOva5g/ukMb1OCQ4cOqXXr1qpbt65++OGH67mOHTtW9erV08qVK+29s2fP2uv+/ftbw8HevEM+MAh69Oih//3vfxo1apQwlmjaiRMn9Nxzz4lnKP8YVX369BH9SH+i+E+aNEk1a9ZUlixZVKhQIXXu3FkHDhzQnDlzbH5Tp0693sezZ8/Wk08+qSVLlgiD4eTJk2rZsqWeeuop7du3jyJjdHAGQ4zuPld5h4BDwCHgEHAIOAT+awQmTpyoDh06qEjRImrx5pvav3+/mjdvrp27dtqqoTxu3rzZKpuhoaE6f/68jYOiSgS+USpRVAk7duzQ9u3bxX3/c/I8cuSI9uzZY5Venm3btk179+4VeRIvakBpXbN2rcaNG6fp06dr+IgRdgaBOLt27dK3335rZ0O4Jj0GzqZNm34zL+LE1LBz507169dPCxYs0OjRo8VsAW3BIEC579mrl5YuXWrbDZ4//vij/T1v3jzbh8RD8S9Xrpw+++wzffTRR0qWLJm+//57jRs/TufOnbNGw6BBg0QfJ06cWD6fT6tXr9aQIUOEcfbVV19RZIwOMddgiNGwu8o7BBwCDgGHgEPAIXCnIOBXQhMlTCQUy7Zt21rvdYLgBNq4caPatGmjl19+WW8aYwLFHGOgadOmmjlzpvVG4/l+6623rBI6cOBAvfLKKzb+p59+quPHj2vZsmX23muvvaZOnToJxb5Lly42DvmQHgMhKp4st1kwf75ixYqlggULaJrxhmNsEAeFluU0eNmZhcAYCQgIEIHnd0qIMA2ZaxR/ZlBKly6tLVu2aP369RZz88i298jhw/rggw/scjKwAgPP8/TFF18oYcKE1hB8++231b17dz300EOaPHmyMAoqVqyojRs2CuNu9+7dWr58uYoUKaIcOXLY/OmT4OD4ymZmnL788ktrWFBmTA2+mFpxV2+HgEPgzkHAtcQh4BBwCMRkBGrVqqWSJUtabzLLUnr27KlEiRIpbty4QulnCcurr76q2LFjq3fv3lYR3bBhg8aPH29nGlgKhOK5ectm9erVS/fee68eeeQR9TWecWYCmH3AuNi7b5/uueceq7Ti0Wa5TOrUqdWqVSvr3Y6KIcYAHnSWHr31VkthGCxcuNBGwWBglgNFmLJYrsMsQ0BgoH1+p3wcNcbAnFmzlDVrVn3yySeKFy+emDnAmKKNceLEUYUKFbRu3TrRByxfAhueMYOQKVMm5cmTxxpdqVKlEkYHMwo7zQwNy7wOHjyorVu32uVn3Ccv+n2PmQWaMWOG6tatp2effVbMXMwy9SDfmBqcwRBTe87V2yHgEHAIOAQcAtEPgbuyRijtEyZMUN++ffVgzZp26REzBhgEKJQoqhgIKPEseWEDLTMDeLyHDRsmlgg99thjOnXylE6cOCmWHu02Xuuw0FA7m4AiSx7MUKCAosyydAnFlE3WLE/CsIgK/rz580RZZ86cscuY2HzL0iRmLJiNwHi57777RLl16tRRgM+niPDwqFnE+N9bt22zGDBrsHbtWtFuliadPn3ato37TzzxhIoWLaqPP/7YLtOyD8wHsw3gzkyMubT//fsf+C5fvrxdmkQfYxAyG8GsAxGHmT5lVoNAX5PP6DFjri8xI05MC85giGk95urrEHAIOAQcAg4Bh0C0QQCFsnXr1nrmmWeUN29e9ejRXRgDKJXMDKCk4tFGqU+TJo3dEI23ulq1avZEHoyMBAkSqGHDhnbte4QihEKLgo9SWrhwYXmeZ0MsMwNAeSizfGM0sJ6+Ro0a1hPuB4X7kydNtjMaLJVhj0XKlCnt8iiWMxGP2Y+nn37aLnFi/wWzCyi2PLsTAnsPWMp15uxZuxzo888/t3s42PPh9/Yzq5IkSRK9//77og9YPgautJ+lZRh04EffsYyMWQPi58+XT8HBwcLgYrMzoXr16mJGgk3RxGP2Yv369XZGg1mHFStW2JkM8o454eeaOoPhZyzcL4eAQ8Ah4BBwCDgEHAJ/CgHP85Qvf34t/+47NWvWzBoLbK5Nly6dKlWqZJcqcQIP3mYMCH7Hjx9f6dOnt88OHz6sWrVqiVmKfEYRTZM6tU6eOiVmBlA+8VyjyGN4YISgiLKMiBkCZheIw9KYjBkzXq/3qlWrrLecfFmLP3jwYHXp2lXUwb/Bl/xQqknE8iQMFALXd0JgX8m0adPs6UYYC+wNYcMyOLGci5kW2ovRgGH20ksvKdAYZFyDDScogf377dqJZ+wr4VQpTj2ib5nxYUaB/sCgeNTM0rCciWVfGBqPP/643fQM9u+8845OHD9uN59jzMVEfJ3BEBN7zdXZIRAFAffTIeAQcAg4BP47BDzPE/sWOJKTDa7nz51X8eLF7Zp51rwz28DsAwZAlixZxBIYFFEUTn43adLEzk6gbOLVZlNzksSJ7exD/fr17axFzpw51aBBA7sWn5YyM9DOKLIYDSlSpNDrr78uZi94hrLLDAV7IF544QVbl4IFC6rmgw9axRdjhSNCWYqE8kwaZhtoA+WTJ/diesAYop3gy/6SwoULi1md559/XgUKFBA4gUHmzJntzA5YvfHGG3bWAAxKlCghDI0qlSvbGQpmaDp27GgNQvCiv0qVKqUXX3xRLD8raeJj0GF0gD3GI+VTLv2IAcLsBEZKTMTWGQwxsddcnR0CDgGHgEPgTkTAtSmGIhAvblw1NAr9iBEjxBGaHKdZpUoVu1kWbzRGALMOKKBsjGXtPIE4bLZFoafpKKJsph0+fLg4WQevdtKkSYUnmyM9OYWHeCyfQSElT9bLo6CiqPLM8zz7joABAwbYTbqe53HbbsJm6RHGBZucqQtr93lIfnjgGzVqpKCgIG7F+JA9e3a74Zz9GSzhokHgy+Zz2o4iz+lIGHc8Y4aHazAnHnhiEGAI8j4GTj3C8EPp97xITDE2eDfDhx9+KO4z24Bhx6xC7ty5ydYG+pDN7xzPmtgYg/ZmDPtwBkMM6zBXXYeAQ8Ah4BBwCDgEHAIOgeiOwJ1VP2cw3Fn96VrjEHAIOAQcAg4Bh4BDwCHgELitCDiD4bbC6TKLaQi4+joEHAIOAYeAQ8Ah4BBwCPw+As5g+H183FOHwG1DgI1OHN3GS3s4nYGMOU2BNaWcpc31Px14Q2XXrl3tGeH+sk6ePGnXebI+lhM0qA8v+/EfLeePd6d9s+ENLNiQyJpW1q3yJlbWnnJiyK20l3O927dvb89Qv5X4xOHlSd26dbNvDwVv7hE4dpHjFVnTXKZMGbG5jk2SbKJjXTTX9BX98s0339jTWHgZEGn/i8DpLNAKdMMGS+owZcoU8fZZ3hrL9d8J5M944fSSypUr282Hf9AvPLeAOwAAEABJREFUf6e4W067efNmcYQmfUVfkJB69evXT9ACL2/iHmONl2lxWgrX/3aAVlhbXbZsWYEf9f2vT2dhzIFf27ZtbX9yDS7QPnTDC8ugee5B482bNxfvLuA6pgROPGKdOseY3o46Q0+sfWefwp/ND3w5PYnjQDll6cb0PP/uu+8EzpzedOPzmHINH4W+4eMEeDnfN76XgvHKMaeceFSsWDG7z2Pq1Km6fOWKeLZz587f5eX+OMhrsONFcOw/4dSr38KK+Bzhyjs2OHkJHoH8p76/FT+633MGQ3TvIVe/OwYBFL+hQ4cKIc7Lc2AgvF1y7NixQsjQUO7xYh+EPcyGexgaCHqUEu7zGwELk8Lw4Jq8SReVEZEOpYv7nBZBXosWL9a4cePEfa4JCGheOPTVxIkiH4QL5VAeAcZI4Ng4hBdpyI88UBR5RuAZdSI/4nKPfIhHHbkmbXQKbCoE/59++kkIC16URH3BHizANyp+YEpbaCttQ/lhIxwKMtjTL7QP4QwO4MG1P5AvihAvCEIZnjt3rv+R2DSHgsmmOc5VR4HixA7y5aVAGDJnz52zJ3v8sOEHcY0wup7Bv/yDeqHEsJmTdtDmpcaQAU+OM6Q60DMY8uIi2s49MIQ+wBes/TTGM38A49dee028LZeTX6AdlJru3buLcogH7ZEejMmbPiFfnhGffAlc0y/UiTpzTXx+Q8fkQ3mkoc+oL3Uk3o2BsmgfQp/NkdANcbjPpkg2jfKbeygrXP8XfUS727RpY423dOnTUR3xwi8MZHthPmgrmPjrC3ZgCDZgAWZgZKKK38T1X3OPMrhPGgJpyIM+AU/i3BjAFUOKfuWYST9+0AJG8ZgxY+RPy4vJoC/efnxjPtH1GtrECcR4zX1twytthqbAm3pzDc3RZjCjveDHWAFfaJLxQhzigylHg0Z9bwDPwZk+IA55+vOAL5EPeVMuG5yHDx9hceUe+ZKW+J7nifdB8F6GQYMHWd5CftEj3HotoENengZPxECHZuDntDFqLtAw42DRokX2qFWOo33l1Vc0f948rVmzRo8++qjmGJ5MX4AVWIIhfcT1DmNQcNLR1GnT7PscMBwwtBgz9D1xCf4xhVzAcIE30N/IF9Lwm3rRf/QFfUz+3IvOwRkM0bl3XN3uOAQ4hg0GwekVMC9OYYiglYZxw8jxVsDQUBxR7BEeeNh69eplPdLtjTcbxR7PBsoTwqBHjx7WW0c6lEyYJYyOUyBQsjjuDcEL86R8mbI8L/KEh8iiI3/zyakdCBDqBQMmbwQdbx2lDmPGjLbGBmdYo9C9++679qxvGCReMM64bteunUjLSSF4YqkXyhX1orzoFGDSnHtO/fCU0wYEArjTFyjs4DfYCFOEBkKFNtIPBM5KBzMEOP2BwkP7mHlgRoBvrv2BPGbPniPScEQfJ6kgLHjOS324/8ADD9i+Bl+OaEQQ2X4zkRA0oWGh15Vmz6PXzIP/4L/nefYoQoxdBPXBQ4fsiTDizzyDzsETDKFnPHkIYjCErvoajzxtxFDCSKUvSEqAVnmBEqeOcJY5RjZeQTADQ5RxvNTQN7SI0AZLTjNBeUBJp5+Y8WBGh76lLPqM8hHU9Bf1wHBDwcPT+t5771lvK+fWM4aoS9SA8bh48WJx6g2KATROn3ieZ4aVZxUurlEgCKT1PI+vfzWA3w8//CBOeqn/WH0784HXFUM0JDREtJV2gx9txQtN/9AX8CXGPH1Hv6LgMBai4gdN8oxxA2bwKt4ojEFCPAzi3bt3/6rNp06f0vz588WJMfQTRoIfJ2ic3+BH/nyTgeWP/IgBAdqcZxTO/Pnz23cswNMxGuHT8EpeAAaekbx0jH2bM8YnDht4CMY32ME3MfhwLtBsz/MsfWEYzJw5UzwjT2YqcVrAZ8C+32ef2eM9mfmD32LAzzPK8MyZM8QLzOAx9Bdjsr2RJevXrxcnA3ES0LChwwR9U15MDNAMbWGmAfkKzXJEbNS2YEiBf548ecTbsuEBnKAEvx8+fLh9ozaGGbwHJR++BVb0yd59+4SzgD78evJkgTmyMnny5NagHjlypJhZQt7Rp4ypadOni9l6jGTip0yRwtI+fB65joxgvNDvlBm1rtHxtzMYomOvxJA6uWr+eQRQirJlz6YtW7cIJR7GgaBEkUKwoGwjOLbv2GEVF5gXAgEDYaYRFMTbsnmzEDh44DgqDqHN9DdnemMkoMQgKGCcKFgwQxQBPC9BceLctNK+gADL+GbMmGEFGYoD+fGiGpgdCgTKLcINRYsj62C+GClMucIwYawoDiiLb7/9tvCwEA8PGfnctPD/6AGGEYwbo4AzuPEGgTl1pb0orODXoUMnuzRi85YtdiYABdPzPPlMoE8515x09Ateq6+//loosswWKMofhtfSpUvEGep4s3i5EtgSpV69elYp6NChgz3XG6W2du3aCg4OtgYG/fFM48Z6+KGH1a9vP2Gkke6/ChGKkOfzrPK8/vvvxfGO4Ol5RrkxlUJhR9FHiUIYclY5ysvWrVuFQF24YIFVVqBThDMKIgojAcWWYx+hIxRdBDH0zT1oinFCv+XKlcvmBc2SL1P+KEEYFPwOCw8TSikKBIYhWDNeoFtml1AYoF2wZWkainTatGnlr5Npxi/+r169WsRHWUMpRFGmPkRiLGNEYODUrFnTHq3JPZ792wG6xfBkvHL0JgomtAiN7d61W+AHTmACnWNYYWSgZC1dulR+noOxRb8SB4857UfJgcZpOzMFGGDQIn0ED8iUKZPgR/AsxkbUtm/auEnwoddff0OFCxcRRgp9QRzqR7m8CwD8MPK4H5MCvHvDxo2CNjDWwA6eAB8Gb2iMcY2B3KJFC/vuBHgs4wa6BzMMX9oMTaNMgjXPoSUUXuJAZ5kzZ7bveQBrZgigcYw4cKRvUIDDw8LsUhvyZixhZNOHOXLk0AwjT3DsIENQoDGQUYYpOyYG2sE4ZmzCx6FxsIAGMSbAgH5gueeiRYvsOy2Qi7ly5hLLk+DztBvMmJ2Af2HwwYugRWRYoJGRnufZ2QWMN4wBVglA0xhg3MuQPoOQkdyjTPKEt/FsiZmBXW1mMugLxiUOJsYqBgX9ShziR9fgDIbo2jOuXnckAjCQMmXKqkKFilYpwQgI8PkEY8JggJEjQPr07q04seMIhoLQx6hAMUf4ZMiQwQqBdu3aCYGSJGkS1a9f3yoBeDxQSivcd5+ddeDMbryFCDKEjC8g4A9xpY6Uh0KLkEIgIbxgug888KCduoXJcW44ghFhhTCEKeYy0/AoypwJTnw8ZHi6XnihiWnzfX9Y9n8RwfM8i2eEKfxqSIj1ErNuHgHM+dwoUpcuXdSxo0etgYACjyKMsoSnFIGEMouiiKcbwwFDoHiJErrnnntMrj//x5Cgf3jDKwKffkdwIygaNmyo6TOm6/7777f0gOf3hRdeEEIQhUHmD8UMhYN6msvb+f8v5RUeFq5KlSurdKlS+tjMdC379ltr3EBrKC3QCMvwMBCgB4QubQAvPK4Yarx0ChpFmecFS01Mm6cboxUlF/rH+7l3z16h6KOUsowF7zm0h8ILLX7zzVKrADBWEL4YdJwrX6liJetNZ1wQF6UXQwOaRUEoXaaMNdzxTEKn9Df5omhgeFNXPzDUn7yDgoKEV5EXP2EsoIB5njGSTCAuBhLtYTxw/V8EXjoFVmPGjhH47dmzxxq6zZs3F8YbGMIbwAOcUHzuvfde2y7aSKAdDzz4oFBwaC+4kNfGTZuEcQYeqdOkEXTKPglwIA4YkifGwMGDB683n3GCk4S6pUuXVnnz5hEzQRgo1yOZH5cuXRKKMfmbyxj1/9jx4/YFX9C053mCv0MvjIO8efNaYxNjAboHIxRL9pc8YGYVaS/hQYM5jhf6b/fu3dZ4AzueQes8g9/DB6BPaA2eDT2/1qyZ9XLzkjfKuc/IAX4/9NBDql69ulV0uQ8NPP/cc/Zlc/AWxgf9Qn/EKMCjVtaTnXlFGScwW4KDDbn6rGlrs9deszMoGAI4ZZC18GlmEeAXzDTwMr2HH35YBBwOyMBLly8LrE8ePyFwBCte9oaMAH/Gued5oiyWZh47fkwYLIyvB2rUsC/aw1BntiPk6lVdvXJFm37cZMfh802aCJmOoYcBgdETtUnR7bcvulXI1cchcCcjEB4RocSJE1uGgiBhLwPtjQgPt8wOhgXj5lnceHHtngKEAYppunTpiGqVW7weKK4omsHxg+0LY4iHgk8kGBfKF8o+5ZGfcV/z6JYCwoeZAYQZxgIKBAotigNMEiWWewgfFA2YKAwzYYIEihc/vhCYCDw8hcw4tGnztrp07WrfXHpLFfiXIlFnlB2mmmfPmqW5c+YIxX/W7Nl2yhqFFcFOn/gCAoxPXeJ33HjxDJzeL2rJbABeRQwm2swLfqJGwGjDk06ZeLAREvTLd8uXa/369cL7N2/uPOs1xBNftWpVodih7NG3KLWTzFQ4RlirVi3tcpOo+f8Xv8MjwpUsaVIxCwAuC8ysgQHGCk+UHO5hfEKr0CZtR/EBJ2jG8zzxHKUFQwpv3fp168SyDta44+lDyZwxc4aYTWDmh3jEX7N2rfVQQ5PZs+ewa5JLGcMFryn48TZX8GWMoLgyFqBb+pvxI/OHAkZdqBf1pR9IyywDb3mlbiaa/Q+tMxYwhjDWaSttmW1oBSWXPkqZKpWIwwwHb/DluU38L38wC4LBdWD/AQ0dNkzUEYMJDzKGEe3CQGNmgT0iKLMYsYxXFHhmX1Awc+XMaRUc8MPYJW2pkiUFn6K9wWasB5sxj9IEfvQXfIHn8I6oCtDWbVuFYsY4QGFjrT95zDc0c+HiRavMolhjVIIfSvW/DNvfLg4+Dv37AgyvMLye9qG4QhMosSjw4A39YjR7nmeie9ZJQeGeF3nNb2gUTKEhvhk/5NHcGH0omdAtOBPXHxIZ2eJ5nnw+nx1XMn+eF5k/s6Asl7nfGA4sI6QPuMbgMNFi/H9oMGPGjHbJG3QOHYIdNPuDmQGFt7AcDscDvIQx4efvjAUwJnieZ/kxs0HMpNOn9JUvwHe9n3zGyecHjHKRzSj8FSpUEMu+3nqrhQZ8McBG8bzIPvU8z17jmAozjhYuAnyRKjh9SV3hQ9yPriGyttG1dq5eDoE7DAG8C1eMx6JQwYLCe0zzQs20MUIXAY3Hg/WMrE2FqXMPoYsCD0MhPt9cI4wIKEQwOn5zn2uYI4pVSSPcUXjxkvOMODDAcCPMyItAWkKo8a5zTXrK4B5KD2lhinhXYJzZs2cXAg8lI1GiRFY5ZKqXvP1l4GlHQZPhkSghGC2HDh66znApJzoE2om3DcEA7iy3GPHll0Lg4D3mLajUHYUQXMCENATqzzXtJqBw1apVywoMhH1Z470mDoF4TINTVt16dYWXixkK9ktgXLC8DGWLKfK33npLzG6goJInxhf4gy3flMU3efKb/P+LQPnUCVzKmLZiUHIPbIJHdCoAABAASURBVFDiUd7xOrNmGuWEupY3XmxohzQIXeLzG3xLly5t32wL/hhbGAekw5BilgJliT0deMUxNnizLksp8IQjsDFOGjVqZE8Ao4xq1arZN9aShrKYESAO9aB/PM+zy7oQ0iyjoc7Ew/NInszkMfbAljTUgfsYR3h5WaaDAgit0H/0CfFoP2m45pt7fP+bgXaiBLFP4d22be3yOPgJbcPzSftpGwo6szIYTlwzM0h98fBDyyikpCE/8ANXz/ME/vQ9p8uEhYba9fqZM2e24xuPNphSBmOHdpPniOEjRFnsRWEpGLNOzKatXrVKKHSkwRnBN2mgC+iDtFzHhECboctTJ0/K8zyBGYp+lixZLM/EUw2W0A5LgOCNzEIwm0X7aC9KLbyB/TiMfWjT8zzrKIIXY9Si8PIMvBg7UWkNvMCQe57n2Rk/ZpBQoFGSkT/MaNDnzGCQx+nTpy0fh98ohv5BL7QZDP1NQF7h7R8+YoSGDh1ql4rhpMOYht/jwCGNv3/AAocBWDGmwRlHDWOasY9iz+wjDjmW4nmeZ2ke3o1RmMQ4T2qYWYXYsePo8KHD9hn1IT59EGYcg0YkKnu2bIK/YLBQD+qIEUgb/HWPjt/OYPiPesUVe/chgDKCAIFRxI4dW8wAsF43Z44cSp4smdjoVrduXcFcYEYwNaY+UWRQjGB+nudZ7z3eQvLgHr9h/gh8lHgEN4KIdZl46/CqFi5cWAj2tGnSCIGOUPP3APmgVGEI+POgTM/z7JIa1o0zRUseMMsGDRoIRcnPVJmapU3kC4MlD4RcFeMh3/zTZuvdZKkCijDp/eVGh2/qhRcaIcJ6Yxj4ooULhSLDFDLCgzXEKFYI+xTJkytf3rxKlDChrT4zP7QZ7x39yxQ2QqVixYpCebCRzAeCAGOBvsJQZNkBxiDHuOYvUEB4rbt90E3096JFi+xJVni5MRwzG0UMryR1oK6e5yllipQiLxQ6k/1/8p+65M8XubmTfm3VqpWdys9hDErq1aVrF9FGsGUJC8rr/8x0f+LEiQWdQicE2kH7MD6h8zy5cwtaQ6HES016POH0BwYEhgWe0fMXzluckiVPJpbBkFcF4+GDVlF8oWf6AuOD/Jh5wAiDdikvtykHukehgw7IG4UWukYZYybC8zyLLX1PWvJnzNIulC7GMP3MWn/yKpA/v1UMScSYoJ0Y7Fz/mwEDCiO4gqFDFBmWB4EbBinGHeu8MQqgd3hHKTMzA37gj6GA0gPe4Ne4cWOVNM/BD28tGOAgYLznzZNH9D3XGMF8o4R5nidmyOAttJtZBZRTMAUz8GMMsK8loXE6MCMCHTCWqAdp4EHcS2LoheuYEMAS5ZNZQcY8Y51jkplZYQzgdMFQYH1702bNhOHJc2ZUMOgwyFAw6S9oEWMbOoWfosyDLzyCJXkYqvQRs3cEP1ZgDi1mNnyD/oPekQGkAXMMb8YTNMK6e3gYzhH4F7NqMQHnG+sIzUA7jDfGs/85bQK3/PnyCb4En2CGAf7EfpuFhteyXIjlSKSFtqHFxIbmmDFmhhfnG32AwQBfoL/oS/AkDThTdtly5bTiu+8E/6ZfoHNomN/Q/oqVK4XxTV/C2xmL0D5LN6kPfAp57q97dPx2BkN07BVXpzsSAZg33iM8piiYKEhsTEPAorDAwNm/gGKJFwkFDGUDhZ3lAAgEBAoCg2viY4DA/PGmwswQNChTKAcsmVi6dKndfIl3AyUKTwYMCgbnB5l8WB7DhkcYHHlQBswWYYJnhnXKKEae59mlIWzMY+oVLzBKLwwW7xWecZRpBNhbLVrYkySoA/VFKfG8SAXMX/Z/+e15nsUGvPHy+wNYVL//fmu4sfwHBRKBzmwLhtjcefPsunDqjmExdepUuxyGPgM72o5ihEJNHAJKFWv2ya9UyVLW++h5nhDsHOmHcZg9W3Z7VCrKBJs/6T/yR4hgOKD4pUmd2i41wLAE//9SwKdPl94ag9AptIKyRD+jWEJf2bJmsxuOwZWZBugEbBDQtAXlB3ojDQosGIEVwfM8YfCSF1gguJmxor3gyrKxlStWihm5CeMnCK+55xlDKmVKe0IXihjji3oVKlTInm4CXsRnwzkGA8bgB9262aVdlM0MCYY6dWWMoCRQFwICnbrQv/SZ53m2DzFOGFucuALt4y1mzJCGNkH7jEWu/81Au9k/M37cOIEfAToGU/iQxc8oMGCCd5u4nucJzPB+s0QPz6rnedYrO9LMurEhHPxoK3mAEZikSpXKerFRTBcZBQwM6V+u/W2Gd7DMif09LBvxvEj8MCqWL1tmN/lTD5Q4+BjpcEww7ipVqsRljAjQN0YuNMRSH5RJ+AmYoHiyzKV69epibLdq2VI8RwYQwJvZgYeMUb148WLh4aafwJcljCi69A+/4btgD72xt+2pp56ye3UoG34OvyY+cobn7NnhFCUMBsqGLgkoyhhz8CV+U1aMAPqGSjLmhg8bLhxktPmGx9cvMSwwiMEAvrRp40Yxk4ORB0/AOYEhxoZ0+gR6R74yxpn1gQ8wPtgHxTjo1auXmC0jbYf27a28A0sMcfgH/UX+4N+mdWv1/fRTsYEaGsfwWLpkiagH4wXHm+d51+saHX84gyE69oqrk0PgNiGA4nCbsvpVNp53a8wtqsfnV5lE8xt/Bj8EDIKIWQa8uH8mbVQYPM+zymjUezH5t+f9vfaAI+G3MLjZ/b8T1/O830oeY+95nndTevon8IuxQF2v+F//gUMHQylDhvT2NCh/Tp7n+X/e9BtlFuMyXdq0N+0vf2LP++P8/HFv/PY8zxp4uvbHzAZ0gNHB97Xbd/wXffVHjfyzeHie9wtsdQt/nvfX+/IWsr+tUZzBcFvhdJk5BBwCdyMCnucJDzpGA0tb8DjdjTi4NjsE7nYEWKrVtWs34WH+M1jgJWcWhlkFlhX9mbR/Jy4zPqyjZ7nO38nHpb3zEYiRBsOd3y2uhQ6BfxYBNiwyFcoRcP6S2PjGRkk2LLOO1n/ffd8aAqyZZ/kLyy8879deI44sZB08G+jIkY2JTFWzFpbNjNxz4fYhAKbgy/4Df64s+aAfWKfs7wf/M/f99xBgHwfL6dhESk7wEPBnaQ19wb27IeC5ZolL6tSp/1RzmYllORHLWDzv1/zjxszYoAu+LH3yPwNzTrSKymf8z272nThxYru2/t80Um5Wlz97n/HMfgJk2T8xnjnhivzB+s/U7ey5c2LJF/tF/ky66B7XF90r6OrnEHAI3F4EYKysP2YD3vx5823mKFBMSbOukj0TrAUlnn34z37c8bkj1LZs3WrfE8ApTJxqgnLFaTus4Wb/CUfyIejveDD+hQaiNLHhtH379mKvB8oExXKf5Rec0sOeEDYxct+Fv4cAuHIwAHt8WrzVQjgeCLy4kT04BN4Xw6ltf68kl9qPAEZZr969xfJH9ktwn35AQWX9PZuloxrKPL8TA+1lZpcjemn/7W4j+wvh07t37/5TWXPASOs2rdWyVUt7utWfShyNIzuDIRp3jquaQ+CPEMBzhwcEjxKbtdavX2+PLsQzwmyBP7Dpjo2jeKPYnMmJNTBBBA+GAWfd4xFhUzSeJjZfc4rKH5V/tz1nVgDjimP02MQI5iihKJ94+8AZzP3fnIgCri+9+KLdoEs8z/Pssa1sWGQjeqNGjexmPfK62/D8o/aiBKBoQt/QOZtgt23bZs/sZ6YAZQm8CWBO3+zZvVucOAadgz/0TT6cVNPw8cftuwDOnT9vjzz8o/LvtudgtWfPHkHfzHwtW7bMHlOLh5WN0zfizek7bAx98aWXRN9cOH/B4kp6Nvuynh+FDgcEG6LvNjz/qL3QJSekQd8EMIRPgzcOhBvxhvYxzjp17qwPP/jAnq4GD6cc+oqTdtg8jocbRwX37+TAIQSMcQ5DgBbBjlkueCk0CL5R2w8vwYHACVTcx3EDX8G4AlfSEXbt3iXGAvKVTeFgzMw7fYQzAtnIxmeeEY9Tpr795lu76RkZywEQjzd8XLNnzba8nrL8gTrR57wQkf6GjyFXcCRRFwJjChnuTxNdvp3BEF16wtXDIfAXEEBp5WjC5s2bixddcXIDswcID16chmePgAebUzNgiihWefPlEycwwbzwBqIccPzcG2+8ITzeCCaE1l+o0h2dBMHCel8wx+ji2EROH0FI8Q3O4O0PCHz6iNOA2NcA3gROt+JYPfLg2D1O9kBo3NHg/YXGIZyhZ95XAT1zNC/Ygivev6h485sTvXgT8eEjR8Q7SDB+wRtsOTaX44s55chnjLa/UJ07PgmKFCdM8dI7vNQo++3atdPmLZv1cc+PBcbg7//m9BiWHHFMMyf++AGCt9glOQZnlC1O30GJ8j9335EIQJc4DuAjzAxg6DIDhpNhztw51/H2Y84JSZt+/NEadJyqwzKmyJwk3hrNJl2OxvW8P17S5E8XU7/BbtKkieKYUsY0+z9wvvhpE56B4h21fZyIh1MMfEnPUcDwYfgJso8+aNW6lZq/1lw7d+20RwaDKYE3P3OaHco+Dgr6acmSpcJIIR0zCpyC9cknnwgjhhP1cBD5y/LXA4OcfW44kUhHfTmBDAfeK6++Kow+8sH550/zn33fULAzGG4AxF06BGISAng6YCy5c+cWyifMbPac2cqRM4dgaDAjf+CYwgwZMgiF98knnrDnxaNMsZ+BM+05KpFjAVFu8U6hrMUkLP6NuiJk8LTieUJ4FL2nqD0iEe/Qk08+YQW8H2++OV70ySefFEcbcpQe3igw5zzu+vXr6/SZM+J9A6xb5mjdf6MNMakM6BBPK0opx7GyPIAjJbmuULGCEKzg7A8sf+E89J4ffyyOtqW/aC/ryqF7jOaoii3PXPgZAegTLyqzZhwLy5GmHD97/NhxPVbvsV/RN+8GYVkMR07CW0gPfXNkLkrcpIkTxWwlJwDx/OeS3C8QACs84yigLAfFYAD/NWvXqlSp0r+i71q1aql4sWLq/tFHql69un3ZGnmQF8onx3xy/DbXd3qAL2zZus2+NBD+iZefWV4cMBhg8AjwIB4GAU40jFZk5sKFCwUfxxmBs4Z9Z7xTAZ5etkxZcazt9u07hMPBjyMKPY4h5CJ5UBbydtr06Xb2uF37dmLGmCPHmX1gPwobykmDvCAfjGcMxHHjx4nN7Szbw4DgqFVmhdaZficeBiL14Xd0Cs5giE694eriEPhzCNjYnA1dsWJF61FlluDqlRBt+GGj8HTgPSFwVvSgQYPsNCueP86y9wsaMvHk2aUE3MOA4B5eFb5d+BkB8OGKE0XY4Jwvfz55niempgcNGmLP5AZvPFcEhArCCI+rPy3pCQigp4wxwRQ072jA6OO+C79GACWfM+YLFyls3xWA0Gb/Dd5w8CZA47zTIX68eMKjHZV+Pc+zigUKw69zd3eiIgCd8qI73m2Rv2B++4iZNd6RwMvgwBraJuDB5XQfeJCNaD7AnaUWLEHC68r7XfCJcV5DAAAQAElEQVS0sizJPHb/b0AAvKFXPNJgjsMGQ5f3U9xI37wfg1kF4vMdNSsUVNJ6nhf19h37m6U/KOC8BM3zIuUX76zBacC7VjiEguU+zDw8/L//CeOXd+jwwsW58+bqq4lfiVl03k2BYo9xAH3zfgscQBi/nvczltA1wfM8y/M9z1NYeJhYBsksfdfOXcUSKfpu7759FndkLXlxjxvUl9n7VClT2T1t8DSW7WFUUB75M3OEc48ZadJEp+AMhujUG64uDoG/gACMjoASBdMxfExJkiQWy15Qav0BhRRPK0UgpAj85pQMDA3WdzK9CvNCweVlVjx34ZcIwNSZjfE8T6FXQ62hhQc1d+5c9gVufrz5Rpn6ZWpZYYM3jOUeLAVjszkzDihlcn+/iQBeQHAPuRpiNxF6nicEKhhHDZmzZLb4+jPx07j/2v8d4f8Rrb7/+8r48ULxAu/QkEj6DggMtCfpRMWa38wk3Fhrz/PE+muUpEwZM1njDYMCo/rGuO5aln/48b7Oww0wyZIn/xU/QQn2Gwr+vjJR78r/OL1YWuinK8/z7N4mHDDwVe4zY160aFExy8tSn0IFC6pChQqWPnmhGjKSlxaOGjVKnTt3Vrny5cVSJmSi53m/wBXc4dHse8BIQPlnjEDbyIOaD9W0edd44AErez3PE/GRzaQlM+IzG4KBQT0xaDAgkiZNZl/ICV8iEDc6BmcwRMdecXVyCNwiAizZgHHx7XmenaL2PM/ONjDDMHDgQPkD6yZhoGSNsCGQDmGFl4X7rF3mTZWcoOSPy30XfkYAvDHMuAOGKEYJEyUS+Pqx5pu3rZYqVYpoNpCOuFzgbWVtK/f43aRJE3sMH89c+CUCYO3HjSdghuCt99hj12kbvAkvvfiSMN6IRzrom8C1P9x47b/vviMRAB8CV376jhsUJJZrgHHUwClfxCPQR/QNafGUo4yxBIw3gTPDwBIx4rnwSwTAC+zAmidc812jevVf0febb74pjGeeE480fHPtD1xz3399p37j5GJ2geVzzIrDE9iD07NXT7F0EWX9McMjWOrFG93Zg1DdYMoejwL5C+jUyVN2WRAKPDIQpZ6lYcyMkY/f6AVPAm9Jpyzomf1QlOl5nsqXKyeMhnnz54vle0cOH1Zw/Pi6dOmSnX2gnv4+w3hgpoN79CVLKjEY6tevp8DAAGvwwLeia/85g+FOHU2uXXcFAnj58Iyw3hGPC2siUT75/XsAINBZd8ybRYlXo0YNsXQABsvyGPY/4DXhmQs/I8DMC+uM69SpYxVTprfZFMq56z/H+vUvBAq4IsgQGni1WG6Al4v1to0bNxYvfPp1yrv7DlixRh4hjQHL0gGORMVLiHfx99DB6GX5DF5ZfzwEN/sdnn3mGTn69qPy87cfH2a9mGG89957Bd7MTv4c69e/iMumUTamM0aIz7psZtE42pa15BUrVvx1wrv8DjO+LKGBNyRNmlQsKWIvGvwYBfb34GEpCzwEw8wfD77PwRevvvKKUIL99+/Eb8Yv9MlsLV5/lHro95Haj1hDgL0z7BO7se0s52rdurVw6Dz88MNGUQ8UvIIN5VWrVFGjxo2EcYFMZT8EhjLLvRgT8Gv2UsGPoO8yZcoIg4T7fLOUiMNH4FPstUL5h9czPqgHRg2HMeDMY8aDcvldr95jYjYOmVzn0Ud/MUtKuugSnMEQXXrC1ePfRuCOKI8TIho2bCg2FOJZZdMVpxzx+/camDlzZjVq1EgIduLBfBFSCH02Y7Hcw/N+OSVLvLs9IJDZeMjMAcKetd4YWalSpvxdaMAXxQkPF0oweyCYzeG0JX9wBsOvIURpQsDWrl3bKvgoVZz3zwZxz/t9+sQjyFrm1FFeoIXgZq04Xr4/GiO/rs2dfwd8MIJRRsEnT+48Am88or/XeuKi/DA2oHXGBhuiOZGGDZwoU3e6Avt7+NzsGQokPATegKGFUVyvXj2xjIZnN0vHfRRaeDjKKdcEeAvr4uEz9CX37uTA+GYpLZuM2Y8A7UFr0B3GANc3th9cMQQwrPxL6vx8hdMG6z9WXxgHxe65R2wgx2HB88SJE9sTjHD6QOekz5M7tzXMKLP5a6/ZmQ34jud5dnYos5Gz9EfUOtBH9C98H+cFBiP9zqEYzzRubFcHRI0fnX47gyE69Yari0PAIeAQcAj8BQRcEoeAQ+BuQwCHGbNaCRMlVL3H6tllczjP/mscWIKHIcjLIzE0/uv63K7yncFwu5B0+TgEHAIOAYeAQ8Ah4BBwCPw9BExqlhixt4Nvc3n9f9T1/cwgMCNepnQZVapYyR77y76G65H/ox/MGDDLwaz9b1WBNtwYfitedLvnDIbo1iOuPg4Bh4BDwCHgEHAIOATuQgQwENh8zPIgFG72BPB2Zv999tqxb8EPDcvfOG2IvWS8a8F//7/8ZiklxsyNdeCI1aHDhtmXrHJIBu+GYf8Ke1F4p8ON8X/vmiVYLMXieNnfi3c7nzmD4Xaieffk5VrqEHAIOAQcAg4Bh4BD4LYhgFHAKUXMGowYMUIcP8qGYvYUsLF5zZo1YmMwLztj9oFNxRTO6UW8EG3nzp1c/iLgySce8ck/6kPuE7hP4BnfBH6Tlt98c01c8uGbawLPCdzjm7j8Jh6/ieMPHJv7zdKlGjNmjDiQgSVLw4wBQd051Yl4v5WWfMmPZ+RJYGM2uJw8eZJk/0pwBsO/ArMrxCHgEHAIRFcEXL0cAg4Bh8B/jwDHmXJkKYoxL1xDkeaFjHjrmVVgcz3PFi5cqI4dO4qTijAWOF2KE4tu3JyPks2sA8f7MgPBywfx5HP8Ly8dxMOPAcL9CRMmiHc3TJ48WXPnzhVxeFcCCj0bqzFSOEnpvffeE6d+bd682b74jWOxhw8fLmYMpk+fLrz+zBgQb8aMGTp37tx1YNnYjpFAGmZPkiRJYjdHDx482L5Ycv369aKutI3jzan/7t27NWDAAHF6Fi+WW7dunXgh6Lhx47TLPJs9e/Yvyrhe2D/wwxkM/wCoLkuHgEPAIeAQcAg4BBwC/zoCMbjAs0a5RhEvX768OKkLQ+Dpp58WxgMno6FAM9OwePFibdmyRSzn4dnBgwf19ddf66effhLeeDz5BJR8ljQR//CRI+rVu5e+++47UQZ7DHhh26rVq9W+fXtrfGBMYCBMMkYD71lA+f/000/FkieMkyFDhggDhXeRcNywXWI0dKg4znzBggXauGmT2IQ9a9YsG49TkDAaqBPdwglNHNGaI0cOJU6UyB7pysZtTrravn27OGJ77ry54sVzHG2+evUqUUeOiMXwwIDCOKG9Z8+eVcjVq9qxY4d9fwP5/9PBGQz/NMIuf4eAQ8Ah4BBwCDgEHAIOgd9FICw01Hrt2TSMck1kjodl5oB3LKB446XnSFM8+HHjxbUKM7MOKNQYFLz/oIOZfcAjj/f9xMkTYqlSYECAHqv3mD0qFU8+xgXHiHfu1Em5cuUSyj9Lfa4YJRxFnLLJl70C3Of4cpR4FHzu8cI17mNYcPwqS4Ry5cypFStWCOOmYsWKYmaCWYcb9xmQL20hPd+UxazGxo0bVahgIXu06r59+8R+h2PHjglj4sCBA+I4b4495qhp3u/AsbAs3/q3TmJyBgM99e8GV5pDwCHgEHAIOAQcAg4Bh0AUBHjPDct08Oj7FfjVZgaAdx8sW77MeuRRjjk6NThBsOLEjmNfcuZ5ke9k8QUEiPh9zawAS42YDWj3fjtlzZpVLDtq166dXd7jV+B54SYvcuMdCJ4XmQfV8QUE8CUUe8/zhCGCl7958+Zavny5qKeNcO2Dd+hQBrMaLGVitgEDgpkSXqzneT/nfS3Jr744ipX0c+bMEUYGRkGa1GmEcUTAEGF5FrMhGBMYUGz4Bg82Wf8qw3/ghjMY/gFQXZYOAYfA3YKAa6dDwCHgEHAI3A4EEiVKJF6CtnTpUnXs1FHsJ0DJ/+qrr+SZf5TheZ6YfcA7HxIaYpV6v5eemYEGDRqIJUgo9uQ15espdnkTm4wxRlimxItJ2Rcxfvx4TZkyRcw4eJ5nDZK4QUHasX27Fi9ZIvY1yPydOHFCLAfiZYQsG0qWLJmYWcCQoGy+qQ+GAwo8L4bjhYU845jX33ppYWhYmMlZIh0/smbLKtp/7733ihewep4nypsxc4bOXzhv9zbwAkvqcvToUWEknDp9ys5oMLtCHv90cAbDP42wy98h4BBwCDgEHAIOgeiPgKvhf4oAy49YYoOyvXLFSnXp0sWuz2cTcJEiRYSiX6hQIbEsKXGixCpSuLBYIpQ0aVIVK1ZM7A9AmUfRJn7evHmVPkN6sfF50aJF4h7e+ooVK9r9At9//73dH8FmaxrOEh+UcmYW2LOAF5/ymNFo3LixPM8Txgt7K7JkyWKVfZYfsScBbz9Lm1jmxEZl9kJgPFAHNmuTvz8QN3v27LbOGAncr1K5ipjBYKP11KlTxcwHZWfPll2HDx0WG6UxDKgH99njkTVLVjsbgQFBHv90cAbDP42wy98h4BBwCDgEHAIOAYeAQ+B3EWBDM8oySnTVqlVV0Sj2BDz4nCSEMo2yzJKf0aNGq3TpMkIZZyMzy39Y589SIH9gBgEjoGjRonZZEicpkcfYsWOF0l+9enWrtKPYcwrTF198IY5yrVSpkordc4/18GMQcGIRdapcubJQ9FkuhPGB8eBfzjRo0CBhJFAf9hpQJoG6YXz468Q3px4x61C6dGm7WZt7HLWaMGFCMcNAPVnKxPIkMClbtqwyZ86s4sWL2+VQnJDE/gjqnzt3brEM6neBvU0PY5rBcJua7bJxCDgEHAIOAYeAQ8Ah4BCILgiwuff1119Xq1at7HsKPvnkE3Xu3FlvvfWW3nzzTbVu3doeX8rz19943R6tyuZnTiYiXps2bWw84hLw9pPmo48+Uq9evWx87hHIg/vsC2CzMZuLOe2I+5yAxPGm5M1xqeRPPhxryn3uMetBGWyubtu2rVq0aGHLJi7pOVq1Xbt2oizi3Rg44YljXf3piEfZ5E85lA0WPKcs6k99qQdxKYdryuL9FP6lTf9kXzqD4Z9E1+XtEHAI/A4C7pFDwCHgEHAIOAQiEcAzv3v3bu3atetfDRgqhH+73NtRHqc1Pfroo3a5VCSK/9ynMxj+OWxdzg4Bh4BDwCHgELg7EHCtdAj8TQRYzsPa/dSpU+vfDOx9IPybZd6ussArKCjobyJ/a8mdwXBrOLlYDgGHgEPAIeAQcAg4BBwCDoE7HoHfaqAzGH4LFXfPIeAQcAg4BBwCDgGHgEPAIeAQsAg4g8HC4D4cAjENAVdfh4BDwCHgEHAIOAQcAv8OAs5g+HdwdqU4BBwCDgGHgEPgtxFwdx0CDgGHQDRHwBkM0byDXPUcAg4Bh4BDwCHgEHAIOARiBgJ3ai2dwXCn9qxrl0PAIeAQcAg4BBwCDgGHgEPgNiDgDIbbAKLLIqYh4OrrEHAIOAQcAg4Bh4BDwCFwE0GTkQAAEABJREFUqwg4g+FWkXLxHAIOAYeAQyD6IeBq5BBwCDgEHAL/OALOYPjHIXYFOAQcAg4Bh4BDwCHgEHAI/BEC7nn0RcAZDNG3b1zNHAIOAYeAQ8Ah4BBwCDgEHAL/OQJ3hcEQHh6uHTt2aMWKFS78bQwcho6OHA04GnA04GjA0YCjAUcDMYUG1q5dK3Thv2N13BUGQ0REhPbv36+NGzdqw4YNLjgMHA04GnA0AA244OjA0YCjAUcDdzwN/PTTT85guBVrKSAgQOXKldNTTz2lp59+2gWHgaMBRwOOBhwNOBpwNHBH0YDTb5x+dzMaeOyxxxQYGHgrKvNN49wVMwy0HqMhVqxYujGEhYVp165d2rZtm/bs2SOuAfXGeNHpmrYcOXJEp06d+kV7qDttuHTp0i/uR6e6u7r8mgYdJg4TRwOOBhwNOBpwNOBo4J+iAfRadOG/E+4ag+FmILFMqVq1anb2oWHDhipSpIgGDRoklG7ShISE6MqVK9enckJDQ0XgPoHlTjznHvEJrBPj3tWrV7m8Hq5cuSLuodgTwiMiRB6k5T55cX358mVruJCQvHhO4D73zp07p3feeUc9Pv7Y1sWfdtOmTWrWrJmWL19ONPuMNKS1N8zHjfmbW+6/Q8Ah4BBwCDgEHAIOAYeAQ+CmCNz1BoNfsX/mmWfUpUsXFSpUSF988YW2b9+uvXv3asCAAfrYKObLli2zCvjChQs1ZOhQ9evXzxoWs2bNUu/evfXVV1/p/Pnz1iCYN2+eevTooc8//1xbtmwRhgDfffv2tXFHjx6tVatW6fChQxo5cqQGDx6sr7/+2pY3cOBAffDBBxo5apTNj3oMNeURhzz99cBo2LBxo60rBs4eMzsSN25cZcyYUcHBwTp+/LhGmTxo05gxY8SMxL59+2z8jz76SGPHjtXJkydvShjugUPAIfAHCLjHDgGHgEPAIeAQuEsQuOsNBs/zhKJdoEABValSRY0bN7aK9I8//qiWLVtaZZ5ZiLffflv7DxzQ+PHj9dGHH+pbY0B06tRJb7zxhlauXKl27drZTdWrV69WixYt9P3339u0r7zyin744QdrBIwaNdoue2rTpo2mTp2q3bt3i3w//fRTocxPmzZNgwYO0gFTTldjvKxbt86mJc7MmTO1YMECO4OAccD00vfmOXXDMJkyZYpOnzmtufPmWsNjyJAh6tixo44eParu3btbg6ZXr17q06ePDh46qMmTJ2vr1q13CZm7ZjoEHAIOAYeAQ+DmCLgnDgGHwO8j4Pv9x3ff03jx4tlGs7xn/vz5Ck6QQGnTptXOnTut8h4eFqaCBQuqu/HSp0mTRhUrVlTbtm0VFBRkFX1mGlKmTCm8+L379BZHWc2ePVvk9/zzzwkjo3Tp0nYmgqVC7EfAwGjevLkerFlTDR9vaGckmBE4ZGYgiJMqVSq7BKlbt2525oPZCZYhsZSqa9euym+MHerHMieWIJ0+fVqLFy/WfffdZ2dCZsyYoUceeUQsgTp8+LCtS568eZQ+fXq5P4eAQ8Ah4BBwCDgEHAIOAYfA7yEQgwyG32vG33vGPoFjx45Zz/yixYsUL248ZciYwW4cDrl6VSjhJUqUUKaMGRUSGqrYsWPL8zyh7CcwBoWu/XmeZ3eh+3w+nTlzRpcuXrLx4sSJY+/j7T948KDOnj17LYXs/cSJE1sDokP79nYJFDMe8ePHF/kQkX0HbHCmHpTN7AL3WXrEtynWpuc3wfM8W3f2YWB4MNvBxu6qZgal1iO1lShhIg3oP0D9+/cnugsOAYeAQ8Ah4BBwCDgEHAIOgZsi4Lvpk7vkged5OnHihF0y9Pzzz2vsmLF65NFHVPPBmrr33nvFXgGMCV9AgFKnTm0NBvYkYGTg/cerD1TcY3d7TTNLQPzWrVurVatW1stfuXJllSlTRiNGjLD3mG3wPM/OJJCPLyDAbnI+c/aMNSb4Jm/2GJAvRgbLiVialD17dhUrVswaGqFmtoOyyYNvQlhomDAkmPlg8/Mrr7yit956S+vXr9eq1au1Y9t2JUyYUEmSJFGKFClI4oJD4N9HwJXoEHAIOAQcAg4Bh0CMQeCuNxhQwNm0jLFQt25du96/abOm1jj48MMP7R6FChUqqOmrr1ol+7nnnlOTJk2ULFkyuxSJNBkyZND7779vlyqVLFlSKPcPPfSQ3W/Qs2dPu6QpU+bMKlWqlKpWrWo3JqPkZ8mSRZRRqGBBsRTq/ffe13vvvafKlSrbTdP33HOPPUUJQ4XlRU888YTY75ArVy69+OKLeuLxx+3+iybPNxHPcubMaTdoY5zwzgmWRVWqVMnuZaCezz/7rK17+fLl7QZv0sQYSnUVdQg4BBwCDoFoiYCrlEPAIXDnI3DXGwx42dnojCFAqF69upImSWqXEnHiEM9QzlHYWQ5UqWJFu28BL36tWrWEgYDxULt2bWXKlMkuVyIuaZ41Cjr3mIVYt3at2EvASUecvkS6dOnSiZdpYHB4nmcNDtKh7HPEKwYDy5KSJ08uZi5eeOEFFS1a1O6XYIN22bJl7dIjDBqMhFQpU4l0WbNmFcucHn30Ub1qDB3qRh5pTXlPPvmkNTaoe9KkSe98CnctdAg4BBwCDgGHgEPAIeAQuBUEbhrnrjcYborMbXyAUcKJRcwOsDyIo1QxANgD8UfFsLSIU44wXv4ornvuEHAIOAQcAg4Bh4BDwCHgELjdCDiD4XYjepP8OGmpfv361uPP3gg2Nt8k6i9uMwvB7AEzGr944C7uXgRcyx0CDgGHgEPAIeAQcAj8iwg4g+FfBNsV5RBwCDgEHAIOgagIuN8OAYeAQyAmIOAMhpjQS66ODgGHgEPAIeAQcAg4BBwC0RmBO7puzmC4o7vXNc4h4BBwCDgEHAIOAYeAQ8Ah8PcQcAbD38MvRqXm3Q6EGyvNEa+8FI53Ptz47MZr4vAiOdLc+CxGXMegSoL1jdXlxK3f6sMb4/1X19QZ+vivyr/d5frbw/dfzfvvpP2jMskbvO+08QidE/6o/f/Vc+oG7v9V+berXOgHfsL3X83z76S9lTKp351E39DOv92eP9NH1I9wK31zJ8cBs6tXr972JpKvP1Pyj3rtvx9dv53BYHoGxv/NN99o7ty55ip6/edtzd9++614S/RXEyfq8OHDf6mCp0+fFqcz8QbqVatWaevWrYJQeYP04MGD1aJFC/Hehp9++snmv3//fg0aNMi+J4L7AwcO1MaNGwWjW7dundasWWNfNmcju4+/jADCcMmSJfb9Hxy7Cy1yb8WKFfZlgryNe9++fTZ/+uurr77SgQMHbP/xjg/eIeLvy0OHDqlfv3427N692/avTXjtg77lWN/Ro0eLfr92+xdfMDDqs2PHDnv/yNGj+sL0fd++fe2b0O3NKB/btm1Tr169NGrUSF24cEEXL160xwdDr1GiRZufYEidwWD48OECT17cCL2DdbcPuum7Fd+JPqDSK1eu1HfffWfpnmswXPrNUvscoTpz5kzbT4sXL7bvTCGOP5Av4wZ8SMfY8T/jmxczTp48WdSDQB3o/3nz5tk84UfUl7j+wEshhwwZYscq45B6Uj9eBnljXH+a//qbOvISSfgHdeFN9xMNL+vcubPmz5//Kz5y2vAqcAU/4kNTYHLo8CEuLf3TV7zDBgzszWsfYLxhwwbL64YNG2Z5OveuPb7+Rd99/fXX2rx5s7134OBB9R8wwNIy9GFvXvtgTKxevdrmST9RZ/ph1KhROn/+/LVY0eeLY7vHjRtn6Wrs2LG/kBmLDZ3u3LnzemXpE+5Bd9zcs2ePFi5cqCtXruj777/X0KFDBY5jxowRMjIqlqfPnBay44MPPhAyin4mD384d+6cpk+fbutBHtu3b7cyZKjJk0DdKBt8/Wno6/Hjx1t+uHbtWksbyJr169dfH4P+uNHtm/E7ZcoUywdpEzQ8YsQIEZC54AOPhM/7aRv5PmfuHB05cuR6c+CdYI0T7/rNaz/IBx5OHpRx7bb9Yvz76RS8iUN/QeN9+vQRsmK3kQs28rUPxgF5chLj5K8nW7yhH3jPb5V/LVm0/gIH+MKyZct+Vc8tW7YI3g8+jH/ojb748ssvLc+F3/sTzZkzx+o58KsJEyZYXYh8/c/93/T7559/buWuvx/59vN+Pz+Br6FT0Q/wa/pm6dKlQtZTZ39+0fnbGQymd1C0ePEa7z+AyZlb0eY/xApxHzQCDWL/qwIK5rFo0SLFiRNHX44cqWXLl1sF54033rBMn2NbERC84A1GDYPGUEBwQNgTjKL69NNPW0UTpkedqFu0ASqGVgQGxMv6MALebPGmEDhg37p1a6t802edOnUSTA1BjtGHsv/6669bBR5h8M477wimxAsFp02bJvqPPDEOde0PRYD3eCAwUHRQOm8UOESFYT7++ONWAaDf25h6jDEGBoIIWomaJ8yWd5fwbMiQoYJBkgfX1JX0XEengGKEMoVhhSICzWOEM/6p8/lz5/Vu23f1ww8/WGUQ4cyY4whkBCjvSenXt58dO1OnTlXLli2F8kh/0Zf+toJthw4drJL5448/qlWrVnbsKMofSjT9iMIPZowrhHfbtm2tg4BnKKdRktgXRCLwEFK8c2WvMSaPHz8uBB71jBo3uvwGF16MOX3GDIsb+KMwokA1a9ZMKI3+uiI4EaAYCLFixbJG77Lly0T67du2C/78frt2wqiFbzdu3Fjg60/P8+49eggBv8Yo+Qhm8vQ/93+D6zPPPCP6HMPtnbff1jTTnyhr7Uz+jBN/XMYeChUKBm2BD8NHqTfKoD9edPhGAURJRymBpuAF8GkwoK7QDLRNXaFn4tFmsCYt9IxyiSK7b/8+ayxjDEDfGEvkQ1rGNjQ9wBhZjJ82bdoIXHjmD2DfvHlzoRQx1qBT4sJjuIZfffzxx78wBJAr1GnXrl166aWXrHFI/aEXvv15R7dvsHz55ZfVyvAD2gltvvLKK9Ygpg/gv2A2a9Ysi0dQUJBtAkZF01ebyu+ggQd07dpV3bp1s/zfRrr2gWMITIiLTJg9e/a1J5FfjCeMcGSEn05Pnz4t+oY+B3Pew0R/R6aQxZd+hN7he2PHjRXvfmL83Nif/jT/4PdtyRqDGLobbBwrN2b4xRdfWMMJLDCWkWEo8chdxjl8hvv0V69evZQkSRLrVGLsYASgI+L88ecLz4U3wLeRva+99prlUTjzMDjoK/A/aPS3lq1aCrkLrm0Mv4HvJEiQwOpfPPfnGZ2/73qDgUHMYMqSJYt9KZqfKaIY4cVCeHc1g3fSpEnWc8CARxnr0qWLFVR+BnqzTobxjjSeKOLjxYdgP/nkE71tCAZlBQWGgQ8DQFCtWbtGpIH4KOezzz8TzAgBlShRIvuiNhgu3jXif/bZZ1YRQQB+3LOnVShg+BC3v04oNMu/W26Frud59sVvECpGBIyFNiMoYNZly5UTHh7S5s+fXwwAGF9Ho/ygBMG0ChcubF9Qh0N04e8AABAASURBVEAingt/HQEENe/maG0U85IlSgrvKDT1xBNPiHvvvvuuEEAIWmgHgw5hU7VqVbVv314YCyiz9D+CAAEOXUDXMD5/zVBOecEgtIciyjOUK/9zvimjV+9egs5glAhthB1CHSGGF3b9unVEtQG6pf7QYNOmTYXw47hgXlxIedFRwDOWaCcvNeSlidB2woQJlS9fPiEg3nzzTaVPn14IfMaH53kqZ8YEgqWb8aQyNjkiGQDAMFeuXHrm2WfFyxKjMn3GCsbcI488onr16ikwMFDcI50/oFDxcsYGDRuqmRE02bJlE7NJ5IUhRt7Qgz/+hYsXrQBDGMEb4sWLZ2eaihQpIoRPVEHmT/Nff8N74Cdh4eHWWYGAxSB4+OGHVadOHWGE8p4afz3BGc9giRIlRL9gGI0aOcr+htag63z58or2Q5OpUqUSBrY/Pf2Dk+Ohhx7SU08/rUaNGonx4X/O9w7jYR9ljGDyj20cKHi+McLh9/BoeC1YMg6JD7ae59n6onA3aNBAvBgT5QGjEWOfeNEhQN/QEO2H7jDIcuTIoQULFlgjit+8gJS6YggwFngJKLTJe4LwLqdMmdIaajUfrGm9puRTvnx5waf8WF4NuaoUyVMIfgMfglaRJeTrD9A/tAxejDNonbIo54EHHhB0i1MKfuZPg6JG36MYU0+Uv4IFC1pDE7nnjxedvqE3jHjoJFny5Jbeftr8kzJnziyMIoxa2ousR5mvVKmSkL/oHTgucNaBK/SGQsl9aNPzvF80E1rLnTu37RMUf2bpSOOPBL+lDvAc6B4eAo+n79A/6CeUYnibPw0zCYUKFbLec3j4hPETLP/jBbE4IfzxYso3/AVc0N/ixY37i2ozNhjr4MPYxfkDftAtchWHKHQHPaJ/of/A63mOcwHDgBfuImvhQ2QO30DXQk9CfwJbDIX9Bw6oizH8wBxesd7M1pUtU1bMRCB3zACzeh39mThJYjvzRl3IMzqHu95gYLBjbebJk0coEZMnT7YKGgSDR6x06dI6sH+/9Wih4OOJRJliYGJMQJi69sfgRGnjnp+gyH+qmabkXs6cOdXZGBo8Ix5WPAQGA0X4c/+dt9+xHgimgPMZJSZRwkQ6feaMVTbIh/hYswg1FAysYxgpytv369cLJoyyhteS/KgaAuTSxUtWqeGaEBYaaqecGRQwNu6h1DQ0whABiOCGWeNh5aVzKCmlSpUSggFmliFDBuH9Jp0Lfx0BhCE0BpNjGpo+pQ9h+DA4GEz27NmtEYlwh/lDR6+++qpVQvF8xI8fXwUKFLCVoN9RMlFeMTTsTfMB/SG8zU+r7KAg4H06fuKEVTaJSx8XK1ZMDxllDi8Tyn/84GBrxKCUEeeY8WaTBwH6wAhB+EFDnudZrxgKN4wUAUa86BTwojJOUfZREFE8GScIS5RPmD1ChzbgfS5evLg1sDEeDh86JAw43onieZ7oN7zb3T/6yC4pyJQp0/WmInRIi9AdNmyY6CMU3lOnT9sZCcYX+MBHGOvwEgwIFDrGOA4BFC7K8GeKAKS+9CMeMXDPaZRB6k0/oGj440aHb7CGx8WNF1cPGgUxwOezSx7gLyiwKEfMFMB3/PWlb3jOOIBGcWbwGwMZmoT3vPrKq4L/DB061CqSODD86eG3Jw1N48zASwuOKEn+AF3CR4sULqxShrcjuOG9KGykoQ/gl9TDL8CpBzSBgo1TBn7N2KFcaAclxF/+f/0N5tAVXkzwwbvJ7CN8hmWFKIfEoW30ATImadKkdpaHMY58g5b87aDdzKzAdzIbBdh/P07sONZoy5s3r132Bb7wLWQVRiKecjCiLjjboO9ly5bZ5DyHLlDa4GX25rUP5BH9gIJLHXlO/RiPK1etvBYr+nzR/6vMTBZ8ACcgY9wXEKCzZ84a0ooQegSGLco+ceDD9AU0hmOvfv36wkCirbTqwQcfFE4LnDb+e9wnoJjCH/gNHlyDMXwZuuY3fAV9BvygUxReeBvGF7oCeKZNk5YsbMAplDRZMjEGwJ5ZCoxu5An0wG8bMYZ8zDeG8YmTJ4QB4Hm/NLgY08hUnAE4h8CI/qAvcHZh/KLjgTuOURxF4IGhx5jwPE/gD+7cBxLSIyPRCXF8wJ9+2rxZwUYmJzKOKHCHfk+fOiVm7tHb4GnwG2gFGZsjew5rMMBnyDM6h7veYEBgM2uAwk1A6K5Y8Z2dIixhlAU8AzVq1FCwmTqC0PDAMDhhuhASjNHfwZ99/rmeNd5GGAH5ch/ig5iqVasmvCt5jWFCnnhhIV68XSgIfiJEsVi5apV4YRvlQvgZjMcTAoU5eZ4nmABCCgaEgDx95rQd8HjtKAcBSx0pmzrAtKkrBMo1wfM8q3CSrz8e98kPwczvuHHj2QFCHMrDW8LAgdhhMAw04rnw1xEAaxTQ+++/X3geWE6AkAZbBAfClaVEMG6YC3FJA/NjVmrRokXCe4fQIR6eLjy6PKef/DUjDYFrz/OsFwzDkjTMZHzw4YdWuKVOlVrbt20Tz+hjptkRehg0gUYQRqUh8vO8SKYMberaH0wTxohRfO1WtPlCyUZ5adeuncCP8YwBznjGOMPjh6cJ5QglCMGM1xPFn3HHmMMgQ7GEbyBU8EplNbMDGBv+hjKeMeSZ4sYbyBj6dtm3Qki98OKLmmQcE9zHaGn7zjtijJN+zty5QgmjTzE4oAc/tp4XiTV1oT9QBqknxglGA954f/m38v1Px8Ezx/ISn+cTdeMamsBAgN6bN29uZypRXP1tROHhN3QObUPP/MY4xbNHn8CjmG3D0MKDhxLkbwvecWbEMOwIYEoezBwQUJpQVinj0MGDQjlFOatVq5Zd24ww5xn063mReMNP8YSjELYwM1DQADQBncMPaZO//P/6G/nBrA24EJAxLAlCmUmTJo1VYqkj9E69kTM4IjDekhvvOHweGQh9E4d+w4DDcI069j3Ps32HIkxalCFoEQMNmseTXrNmTbsEg1lQaJq4yBrwg58hq6iLP3CPMVXNzJ7iEKEt1J1yoe9DByP3sPjjR4dvZOuwoUOt0wUaRZZv+OEHOyvJzCuzueCAsQmvgdbg4/BolqugUII1Sj7tz5Ili53hBSdC1DbCzz0vkiY9z7Pye9bsWYKfsPxR5h70jVMBPQQnB8YEugj0S7/C85IlT3Y9W8vDr11B99d+inFE/0Mb/nvR/Xv/gf3qahyyFy9ctDO1GM3obP56J06cWPAGsIIXrFixwirqCRMk1P8e/p811GgvTgyUd8Y2acGd7+shsgvsJbwswOezv/0fyEnSeN7PET3PM93jKXXq1ILv8xz5QHpoAgcfOpo/j+j6/cuWRtda/oP1QlnAAkQZZpBh8c+aNdtu+kI4MWgxChD4/GYgocQTr0KFClZR91cPRtfUeH4xCBBy/vsQB4EBCdHCAAme5ylWYKA1AJieZxkKeaY1jJ2yKRMigpF4nicGNwKAjWa5cuWyxgmCICwsXAEmH4hP5s/zPPP583/S+QJ+2dW+gADrIaX9eFvxpiJgYHLkTf1Tp05lrWIYEEL5454f20zBIUIRtkx7w338ZQRQevAEIbjvvfdey+j27N2rVq1bW6UeAYBHGcHiLwRjAMG8ZOkSu6GO6WOUKAQRguG1116zM0HMTNi+ioiwSzoQ1FwjQOLFj6ciRYvoheefF3SHp7ps2bKCieHZhtkiDBOYGQZmmFBCYKAo0ORBIH8EEl4WhCX0Dd0gaHjOb3+do8s39R06bKjdtAzm1NPzPKGAYiyg4CLgGUtBQUHWg81vvKfHjh+zs3945QgIfAw1FPv8ZjYQgUw7yRODnX5CKbq3fHmrBKDwPPrII3rJGAzZjYFBWfQF/Ad+wHhHecDTx0wPedMX4Am25D3UzFbgOWbdMV73ADOOeYaAQ8EiTnQJ8Kp777tXh48ctntsEN4YBCh/CE5oCRqBdsGMetMe8KZNYMKY2PjjRrv0CuUemsQAwGDCY47nm/ikJ+AZZPaF8QJvhH8y84MRSGBmInee3Ha9PUY58aEJlOmPun9kZ5BQ2jAsyY8+YdaOpRvcQ6nmPnX1PM/SB3TCdXQIjEUUeHCGvqPWiXoTuOd5np05o32e56lgoYK6fOWykAPQNgG6w5gDDzyrpCPQN3wzG9/irbf07HPPimUeGFm1av1POBngSYwnxggyE4wom/LgQ+QH3ZMP98kTR8mWrVvFstgyZcqIpTrQP3FIhwOD39EpUPfMWTIrdpzYljecPHHS0jr0iUIKDSZJksQaamBA3WlrhowZ7DJIDlCABgmMA56TJ9/+wDWBvJDV9Mvu3buFgcYy1iaGh9etW1erVq7UqFGjxNiCVinH8zzhDNq+Y4ddDgNv8RkFl2fkj2zBKYWOg3cdPQI+At6e59mlU8SLCYH9Z8VLFFdoWKjgNdDwrt27FB5utBUjA8GYWXR4A0p6eHi4NbpSpEyhlKlSWnqDhuEZ8B5w9vMWDAn6ANrNlCmzTUd68oGHw0MwrOH5zDxyDx2OPuU38VgeiEEObcNv6ENwJV/4Hr+je/BF9wr+0/VjYFevXt2uT0W4M02KJ4AlSnQoXjCmqs6eOSOEU67cucWm4WFGcONFDDJKhb+OEEo14ylmrab/vucZoyBWLKvsM1AhQM/zrDLINZ4XGCpCDusXBonRAFGjFKIAIgQgYIiZbxgCBIqyiWLiM/lhePiJjjiUo2t/5O/JE/lwi2chV68KYfzkU0+p7bvvCq8ly1tgSAhF4pEPQh9ix1Py06afrBeOAXX0yFEVLlyIaC78DQTSZ0hvhTSeZ5gZ9LfNCM3VZpYJQxHln2VhKFYohSg569evF5tCkyROYves4MGDVhcuXCimWvGSIghQjlgOgLcPDyEGBYo//Vy8WHHlzJFT0Ct0wHpXBDz1wNvKumMUDpYRfNS9u5g1Q4FlXDBmOF2IWTKUPzz2nHjCDAlQ4Lmkrn6FgHvRJTAuGbfghGID42bmAG9c8hQphMefmR0YO4omswngSBs/7vGxXceNQwCeUbt2bbGBt1OnjrYP6Ts8soxj+gs+QN+wlvX8hfMiTalSpYSiD5YoRDzvbLxilMcM4ROPPy5mOvEEshSEZZIIP/DfZZSEoUOGiDEJ/2nUqJHgF4xreBYGXHTBmXpggH7W7zP16d1HfppiOQZ8FHrBEKX+rOn28y5wgz9BQ9xnz81HH3yk//3vf/YkN3gS9AzvBBPWIWPkoihxMANK1Zo1q40nsYfgWcxkwNcrGOcOARr9/LPP7Sk81INrFGJmL3r17GXX5DNzwFIdjHU28sNvFy9erB4ffyxmpnCekIYxh7KF4UN7o0MAH2gNbN4wsyEoIxUrVrRV8zxPyBWwJkAvm37cJDBr1bKVoG+cQ8xsVzcykbi0L3PmzNa4IBMUJ/gUa7LZYIvsmTVzlpipZGa8RPESAm8M3ly5c4llYR06dLAzOdAAiigyizFF/uSJcwJZR79D/8zUszQKfNn0galdAAAQAElEQVSLgSGB4ZE9ezaiR6uAMdCmdRt90ucTu5+MpTwPG1qFJoYOHSp4N/oCM5HwTpYNQdt1Hq1jeXXXLl0tbUOH5EXj6Buw8TzPjnUMQPgwWKCQwp8WLlpo08HnoXGUUIw0jBT2muD4gz9RFrNs6C/QLkors2M4qZj1IC0KLWMRWfG00Qc8z7NGD0YHTiLqFBMCjk7GcO9evVW/fn1Bx1WrVNWCBfOtYw09Br2pffv2gnbZjwAPgFaRmezjhD5ZCULboUtkJtiCDbwa2q1w330C0959+lhHHDocfKK1cfLhWILvQQfw8A8/+tA6lekbZA/lEqgH9YOXY9RAGzyP7jj7onsF/+n6sZmFgeUvh85v06aN3VwIIRUuXFh0JkIEJtDVCPfixYpZptjcTKlDUP60v/WNtY5gz5s3r1CuWE8Ig0aBYxo3ceLEojwICibNb4QRU2YoFQ88+IA9iQXlAq8idYFhQJA8RzCghNAG6otRUaduXWsMIFSpE2mpO0pmHGPgoAyWMd5kGFOrli31VosWomzyYmNPYuMRYTMOyiWMizyoHxtiuY9ywhRa5cqVeeTC30CgVMlSVglBQQHvRo0a2TWtKJ147WDoeLAzG6GNYj950iTxG+bfuHFj0Qf3GgaGcs8SDBhgRaMgoAyjfEHPrFtGQCO8SxmFlY2b5I1y4a+653nWawKj5Dn0CX1A4w/UqCHqAW3C1MiT+kLbMD8MB2bnoCsYLowW5k35/vyjyzdCg9NAwAiFFEHJmGKpCbOD4Ml9lESUVNZ/I2DBArwYd4xbxj1CHkxyGMOL8Uo68EPAIGhRelD4wZ+9SYxDPw6e5wleYMdy/vxW2WBsUS9Oy8qRM4c9GIH01IU8EydKJPodwUV/YGBglKFYycz4wav8+UeHb8/zrGME3JiVZeYGfgKvAkNoBAMVfHTtD/y4xlDD6AR37hEfuqP/EMxgh+GF0MXoIw3P4bEdOnRUkaJF7cwZy4jgideyt18opniryQPlNnHixGIJDIIeIw9Dg3wYdwRoHSUjj3EWUXfSUSe873jKCTbjaPBBvVoZ5R+jtlTJkvaoSJRKqoY8YJYFXs416+VPHD9hvbE8o5+ymZkveBCYEId+g874TWBMg1OK5MnF2OFIVTBEfmB4E8cfyAd6pV/oM3gK/Q/vQSmjb4mLPIS3MaZwXDz37LPKmy+v3YhLXTHCLxiDu2zZckSPdgHsoClwbte+nVIaxwPYojAid59/7jlxDd+GvlD+8U6TBnpmhpex728Y4wK9BKyJAwbpM2QQBh6GFTg2f625dWD60/CdM2dOuyEavYDxwrJGeEe3rl3tgSf0E4Ey4SfwI5yJ6BXoDvAVjBJmp5gthYY8zyPrGBE8z7vOb6BHZBL4YWjCH8CCWV1oj3bCG8ACrOD1YIA8A2donOVwKPTQP/0Bf2U/Cs8Z82VKl7Z701iSSnnwBuicMciKFVaNMAMEP6Fs8GX8URccUOh5GA67d+22exCpq6L5311vMFSoUMGeCuDvJ5gWAxIhhLKwaNEiu+EUguAZDBVCqFWrll1K5E93s2+YMASC1x4FCwGEsIKRoHzAbMgTYiNf7nueZzcow1g5qQJLGMJmkCe5psyjSDD4URBhRDAZiBImzD4JmIHnRQ52yiN/PNNsvmH5REbDgDzPE20CAwQDDILBUfPBB0WeMB7yo22e54l4eAjxCjJ4smWNfh4f6hqTAkwCIcJJJPQnyg19BwOjj6EJhCm0gwf7wKFD1uuEAII+eH5/tWpCccQooB9RzKAFcEAQQWee51mBg5JLOX6FgDhRA/2NAg39c598oHXqg2CHXnlOIC50Qh3IE1q6cOGC9U6h+HJNHtEpeJ5np55pD5gz3sCicpUqdlkFbQFbFEbGLX2D5xRDiHaAMwoQbUf5oZ1gioBhrDNO4R8IDfACO/IEL7AjD3+gT1F46TPK8udZvlx5PVbvMWGIkSdCnbHI2MdQ8Pc7+XKPafLixUvYfU/+vKPbN3SIQkW9wAbDDPzxyHleJJ/iGe2FzzGdz0wQ98AFzMEWxw282I8B/Qjds9Qin3HKEBcFHw8uSgF9Sx43BvqCvoV+eQYdwCMJ5Mc9eBxxrudZp47gj/Qr9cObi2KAYkf86BIYs/AA8PVjTt08zxP8m+dco7DQD8zQsHSCe7QFLOkHrvnNTBu/CTzH6YCDImo/0B+ZM2UiyvXAxmjypx7IPXgdWNKX4O55kf2OcU2f44xgTMBLoH9og2UhyJv8+QsIOXk982j4A2yQx7QD/OAJ8AZ4BM+gucefeEIsOcXzTxOIB73CV7gm8Bvag7+AGb8zZcwoz/OsYkmelMNz4kcN8Bnwpm/gv/AOaMEvS/jNmEA5hs7pj/zGYQEvoZ5cs5SHVQToA1Hzjkm/oW2/3MucOYvgr2CJbIVW4RuMY9oE3uAFbuhR3ANf6JJZmKj8ir7iObSIXsZvxhO8hnyRG9xD36MM7lEX7lEO8egL8gFrxl4ew7foN+JE93DXGww36yCseqbt8CwxrYjwZsDfLH50vw/zxZuHwP29unpepBFxs7ZyH8aCdxuG9Ht5uWe3F4HMmTOLmQeUm9ub8+3LDeaKRwVm6nmRCsHty/3fzQlhzl4Se8JPQMC/W/gtloYQRDAxu/NbCsQtZhNtonmeJxQYvJ5+ozXaVC5KRVC68K6jeEW5HaN+orAwE4miBK1Hx8ojb5hJwsP7D8qbf63pBQsUsDP6KKP/WqF/siA86HjKMQr/ZNI7JjpyjBl5nD//ZKOgbfa0YSj/k+XcrrydwXANSTyIZ06ftu9auHZLeAWwDvFs+e/90TdrRvGK8P1Hcf+J55TNdOdv5Y2Q+zNKBd5i2sHSAKYp+e15nl0H63mRyiBlsdaeZ79Vprt3exFgE/KfEZz0IX10s1rgWYT2eQ7t/N2+RMBjlPJNnjE9sDcI4eF5kfR+Y3vwxDFtfeN9/zXYg/HNxgdjizyITxzwpx+4vpXgeZ7dmMjM1K3EjwlxPM+zvPdmvMqPE9jSHvAj8NsfwPVmOJKePvE/h/6Jz31/+j/6RsFmdueP4kX35xgNyLkb2841uEStP7zEjxl4E6I+5zfPScvv3wr+PElLH/xWnKj3PM+zyz7w2ke9H1N/wxfhJ9D2b+HEvag8AIzAyt9enkOr4Oy/F/Wb56TxPyct8aPG+aPf8BIUWM/7bZ73R+n/q+fwYT9PuLEO4AEuN96/8dqPH/lAc+h+/CZvnhEfTMmP3zcG4lAOafzP/Pf49t/jm3jIcmiBcYGOxf3oHHzRuXLX6/YP/qATWZPPphc2H7KGnw0tMMe/UiybktgrwEaiv5L+76bhNA9OA/i7+bAumo2ttIdNrmwGZWMmg4W1fUwTgx3MjTOM2dPwd8t06f88AjAulpqx6dO/cZ1ldPQTGwXpw6jPiTNr1iz7NkrW0nLSDGnZzAhT5MhJjqf78zW5c1MwljkSks3ibLhlwy4nYtBiaJ/19ixfBEeec3oMy2nY4Mg1GLOpNqrgZuzQL2xOHDp0qF3GRV/Cezh4gLzvxgA/gT79WEOv8J2oWHB0JZvUiQtWHEoBf2JpFhiCK/fYiHhjWgQzpx6BOydj7d6zW9A+ZZJf1HLuht/gwbII1qz7lRy+OZEKPu/HAHrnkA0wAmewBUNO1oGWiccyG2QFG0O5vjFwrC6ykfzBnAMD4Dk3xrvTr8EcfOEN0De6BzTJffZLQYts9OZ4T3gHz/fu2ytwW7Rokd2nAA9iWVxUrKB9+BFpeI7sZv/H7DmzRX5R495Jv1G8OZSAdoMpvDdq+6BL8OD53Hlz7ZJesOFoW/Dn1DV4ODJz5owZFl82OROHfJCj8G9oFd4C3dMn0DDP/QGFH/qnHPgT9SJP9jqxWoW6IUvoR8YNx3jDpzjUgr5kfHHIgD+/6Ph91xsMEEWPj3sI5YnpZabh2PyL4s0ApHNhgHQ+HQhz5D4GBaeTcI/AfeLt3bNHEKefmBioxCMf4qE0wHRJTxru3SxQDulITzquKYN7/jTUH8UEZsM9iB+i5jcEDiH6n3GPQHru8Zz8yJf7/kBbUTSp5759+7Ri5Up7zjSYQPCcDe+Pi4eKOJwfz+Dw33ff/w4C0BC0AbOCTjhCb8HChfa4RxgS9MGyFeiN/obZcfoOG5PZ4IU3ac2aNfY4Ps/zxIkNU6dMten/qRbEtHwZH4wFcGZNKyf3IITAEMUWTzOKPsLa8zwxtghfDPxCCBA8uBgFCB5/2w8eOiROT6JPMLY5KtlfBoKMMe2Pezd9Q89gAg9ijwBLQlFW/RjAYxDA3OOIVZZZwmPpD+gdvsvpRmC5ddtWu+mX/Pzp6QOMCzyoCO0B/QfYjZIox7x7xB/vbvgGS3gBm7iXLV9uFVLoFnzZxA9Ng4M/HooYWMJD+Ia3sFwXmYCTig38bMq9kXZJj+zgRCvGA3niuaUclGOu76YAjcNLoFHkc99+fcU7WuAzKLAYxByvzAmJrImHZnFYoFhyD36O4QWfiIob91BWWZsPtvQfXvIF8xfYje1R495Jv8EK45/3SyD70IHAlzbyDXaMbfZz4BBG3oEpfBw6jrh27CpG2yeffmpnNzEY/EYCyj+bk+EzHTp0sM428mMc0JeUQ0BnQndkhp06YPBhAFI3ZAB6IYY2R5Cz+Zp48DBOvCM9hvjoMWPsEbxcR8dw1xsMdNKPm34UJ9Sw+bBRo0b29BIUKYgNAuPkBo7cYjMQzJDTaJo2fVWcJsOgRLgh8Dla7t333rPKNVOPHOdFfhxlBmOGcUIw7Mrn+DoY7s2IAkJEASHtSy++ZE9SYl0hewcQiNSNo1jZdMcufY7EhAGRH2nxrHFKAoE2wNR5RkCofvjRRyJv8sPKReHkGQEDAAHARiAUzYQJEtiToi5euiQGH2uL2RzkeZ49bo+NgWvXrtW58+dJ7sK/iADCgw2FnAiRNl1a8XbJF194wb54EEbK+nY2OkLD7Cugn6FJlCWWqLGGmY1ZeGqhn0dqPyLezYFC9i82I1oXhQCGNzBWMLDZdMhGRDxCOXPmFJveEEBshGO5AZsduccYwgHB5sHwiAih1PobiqH91JNP2hPQ2PDJmIQ/sFcKhQHlwB/3bvrmgAZolpcboaA+YTBi078fA4Q29An+CH74MRsU2SjLWnz4Nn0FL65cqbK2bttmD63wp+dt6pTBpkP4N5sQUSQYI3gAUZj9ce/0bwxVFEwM3tixYtnmosAwU4Z88eTZe9AmHlj4hF8GsomU02aeeeYZu0R12rRp9t1F0D2Kr0147QO6R/4hN4KCgqxChLJEPyM3kTHXot4VXyxnY208PNluAM+UWY8+8qhQSnFIVKhQwTow2ctD4BCG++69z+LM/jB4NvKXd1ZEBQyFFF7CZl82V0PjbL4lLnSPnhI1/p3wG1pjdozNzHXr1BUn3aGLwDton+d5dk8UBjB6V6zAWDpw4KBYIYHRyslevIMEnION6DWsQAAAEABJREFUntPm7bfF4SLwbZR9nHCbfvzRbppGRsJvXnr5ZbGnBoPAPyOAzoWBAT959tln7emFGBDM8MDX2avA5mZkAroZZdM//kMBGA/wLY7U9udJ/aNbuOsNBoiNHeqcGICShGWJUsXeBbwhWIqP1X9M3MN7AnNj+otTSVDUUMbxTsEwEXIIfJguQv/tt98RcUqVKmnP94ZxMv0Lw+C0DZgnBEGeeBxJwwDgnud5lmmg2NV8qKZ9KQzCkDJmzZ6t9evXCyYM40GgUj5Lq1gPh+LH5lh+sxkSTx3P/XmfPn1aC+bPF8yKwYFnAkFAuRA+v0kLEXNCBvnhIWKjFm1FWED0KE+kYRPuBWMsHNi/n0sX/mUEPM8TtIO3j+MhEcxM/8MMCVSHPuRIOOgOwwEaRbn1PE8wL5QolCXSQp8wOtK58DMCeP9QsmDs4Me4YryDLZ4qDDT4BYY4wqVG9Rr2vG48qxjsUU+sSZ0qlTixZPacOfZMcMYauNMPeBUZg/7x+nMN7o5f8KBJkyfp6LGjevWVV+R5kYorrUd5BXsEOsYDDh8cHnhe4a0YwZziwztJ2rVrp2xZs9qT4EhLwEmDUoaiyuwFs0SUh/BGQWAcEe9uCBhK0OuDDz0oDNoI02h4ATKtfoP65l64uSMhV5iVxnAGc+ieJRkdO3USShNOC97uTDp4CnFtwmsflMMGcWQNWBN45OdDLOfj+m4KnudZnQLMcCggZ6FLxj+bjlFUkbnMmvHOGPgJh15gHON0xLjlmN+oWGNwIOdZ/kJAPsNTOAIUrzZ86k7DGFpCN0OXwgmDJx8axOClrbQfOsNYgg9Da1mzZrHYwwtwgGJMYGxxemSxe+5Rn08+ETNfGF44gnjXCHIRIwRaDo4f3767BJ5/yuhSlEOAJ8GDcPbQX8weoUfCx3mfEmXh2KC+jKGhQ4cKmbxo0SJrROMEMT+0YeNGsvuPwu8Xe9cbDExNwwQhKBR3BAieQwgIDxbEd+b0GSVMmMBOXWMt0rFY/ZUqVxZMlsHIYEZ54Fg+zkxG+JAfhHzu3HlLYJQBQ+AIM+KilENMTG+1M8KNc9sRhv4uIy3l2Je+5M0jPMMwDAYF3n48+ygwlBUWGmo9acxsUC4KH2XxHCKnHD9zCY8IFwOgfv36oh4wK/8zBiCMByFAIC1TzZwbzHIrvKgQOMopL5ShrpRD/oePHOHShf8AAQw56AJ6oS8xfhMmSmRfGEh1MDyh06effppL+84F+poL4oeGhcloZpbG2YgFU/M/l/uzLz1kCUCdunWEFxUDAE8Qv8EdhYkxgQKAkYZTgfj1GzSwswjp0qa1Rr8fSngBSkHhQoX04osvWoMPxcwv9OBJ9Is//t30DS5LFi+xXlecFFHbjtAOMbzO8pzwcPtSJGZ/wX/y15MF30MxYnkps7jwRmjfnweYokAxW8tYwAhEsMPnwR4lyx/3Tv9mnGNghVwNMU1FksmOf+7ZZRrcNTNj4GN+2mc4FVCMmjZtqnfbttWs2bOE1xT8eAa+xI0aUNqQs9B81Ps4wBg7OLCi3r9bfmMQgAlKpOd5wgkHXaMXgCUviUUnwGuNYYZcvnzlin3xI8YXSm1UfQElGbpn2QxHDOPhBkv6Gb0FGc31nRZ8AQFCdkVSsBQSGmIuPfGHDMMwgI+8aPgs+g4OUpwKzK5xEtKjjz4qjDXwBXecarx8D4csqy3IA1oNMrNjYMg1316Az8pRmT/P88QMBmOHJUj0JTTPXhVm8DBKcPbihMZxjIzAiEC3QnYTnzLQuQ4fOmRyjJ7/73qDgeNTd+7aJZb/wAiZTsqQMaNVvvH6MXhR0osWvUco1ggVn89nFTFLNOY3TA/lgcEPMaCwxw8Otj2OlUp6hBTxIDaIwj40H+SFd6txo0ZiyQNEZm7b/5QFs4UJk45rHgT4fMKbj/eBvCH+2HHi2DoRj/xhPEzT8TKpvPnyCcWfskhvQ+R4sj9/cd/cgcGQD8HzPPvCOZg6ggGD6MrVq+J8eWY5THRZHEy8+PHicenCP4jAb2UNk2OmrFzZcsawTWiZJXQUGhJio0M/9BW0CA1zE4MRZQrFlG8MztixYhkHR4TtT+jO86IQCYnu4oAyj0FcrWo1iwLCg3GClwklduSokdaoAHeEM2MVA43lABj23Cce8TE28EC9+NJLom+Y6eM+gTFH+rsZf3A6dvz4r15MBfDgGODzCQOXmRh4NH0Bv2O5ATMQvFAMg7do0aK2T1AYUHq5B90TFwUXAe15nh0vYE5fkBfl3O0BOvRj4MeJeyhEKED0Azga9Kzc8cclDr/BEpkYVaH1PM/yF54TiIOSe7dizj6DosajjdMBPKBlMAHDlGYGMsDnE0uK0BvgNSi1KJ7gz2wlugb4oejCOzJnyWJpGeUYvcXzPLIV8gEZ73mR1/bmHfJBu5ImSaKDBw/oqjGmftiwwbQ3zC6VZrYQ+cZeA2YcCxQsqCRJkwrcpkydIvYsQMPgA/YcVtG+YwdlzpTJvpsLfo8uBS9Hx0E/5DAY5CVL9JIlSao0qVML3oKTAmcFMpZl4swssMwRXZC+KFy4sAqZ8jEMKBOap5+SmfrQ354XOTb4TV9H1+656w0Gpv94EyOeQSx51lUuXbJEFSpUEB1Phzdv3lxsZoFxIsgZnHQsRHTpwgUxA8AzFH48L4cOHlSB/PnFGk8sSDaXotBBfKQlnZ8gPM8TQoylRQSIi2fkjwGCIOP66pWrCjMeNe6TB1PHEB5Tw0yvYwkzOMgbYUg7mKrnbZPjx42z0/KeF8kw8B6RN3kRYDowKsphAGJoYCAgaLkHBpyeg+WNZYwFzCCEcfEcIe15nmBiXLvw7yJA/yA0YIiUTB/my5/PnrzDM+gFBRXDFOZHHN6lQf9BJyxfq1S5kjU2UKrw8MLMiOdCJAIIA/DKnDmzvYGymi17NrtsEKEeNyiu5RfwAAwClhuxRrlTx472jcMY29WrV9c33yy109CJkyRWoPGM1THerTdbtFC2bNnEfgjGJeMJJcLfV7bAu+gDL3+QcYCA8Y3NxuCFvuFB5cqWtUs+GzVqZPd4MbvG8lJomGVhNR96SMVLlFDu3LnEkiU8i6wZhuexBpm9aLxll6U2KAHwcJZX3ljmP3gdLbIOCw1TSEiojDZ/vT4oUShgnueJ5bqXLl8S/QK+0Cpr6fGo4pCCbkmIDIF++YbnvPPOO2K2nmcEZBmyht8EjHDiIW+4vpsCOEBzzDB6XqRcLluurJgZRtGt9b//CcOZfSNskMUpWLJUSe3csUOsUMAzziwD+kjXrl3EaojXjZ6CRxuezuwFe3roC/gJhh70fadhDC9Ab7p44aKdqe3YoYMeNuP+sqHXZs2airZDr30//VRPP/WUFi5YYPeeFi5UWGx6ZmaSmRh4B/sMln/7rcCNwyyeadxYLL+GpqF93mVVulRpPfvMs+rVu5dY7o2+Rf+wSgR80cXefvtt0bcsXa1cubLQzZAFrVq3EnurkAPoaPxu8sILYt8JL7bct3efLly8YF+uGF376a43GBhw9evX14SvJlihw0CEgOhUlGN+wxxZE8jmYpQDlucgzEoULy6mn7A8WaPZ3AxYBBO73rEwu3btKojJnx6FgylGiOiPCMLzPDsAEIbUg9NAEGa8LRAjAEbNsikUFAiU5Q8ohEzDsybST/Rs7IOImYpjcFEuRlLXLl2t9wJG8tZbb4kZEJ4RMmfOLOrKIEC4cg9j4cEHHxDxMYKYXmMpAIIFaxvlCSuduC78uwhgOLZp00aVK1W6XjDeDTwVKEkYofQVtOCPgEEATbdq2Uqska1dq7b1TuH1ov+hX39c9y0hlD7r108IBfBgLDGVzXTyVTOTwxIXeABCoGfPnnY2EmGEQf9Ckyb2qD5mG4oUKSqER4b0GcSUeAdjULC0A76AEGFJJIYCY9nzPN2Nf2xAhMfBa29sPxihoGIAgxM8liUYYM4BDzhSSAu9s0Tsow8/VKpUqYWBwFpmZlrh0fBkliOhdGFgsJEahxFj6cYy7+RreANLs+rVrXt9eQW0DS4cBELbkTtp06QVXlrwQd5A7/APjAL/mMCwAHN4Bx5UMEYWkQeB38Sn3zAekK28uRz5xvO7KeA8hA5r1ap1vdm5c+UWxtPSb76x3yz5ZYMzDh1oE54xatQoIa/hHcj+BAmCrRIKv4C/sLcB3Fl9wAwbMzwsyYN/IQ+uF3aH/EA/gYYxrJipBS/G+O7de1TVzAajuKc2swANGjYU+IANSj56DEuCkHU4DTzPs7ORzZu/LpZ1NXr6aavrMEuMscD+A8sj/veQaj5UUw3qN7A8HmzJF8M3KCjIHiTDjDKyluXgGAv0Exur0R/hbbt37xb6FOWwYqOEcWpg8H3e/3MF+ALsrHN07Z673mCgYwKMpy9H9hxiLSGKOAyS+wSYGUyNzcsYFwS8XBApCjKWIekRbswosEQI5RuGSWBDMgYCBobneYJAUcbJ+48CZUPslIX3Psh43Sif3zBu6oFhg/cBzw/CknsYFdQJhlGjRg3rueTaXx6MA6ubvGBcMHry8z8nPYTMJk48IUw/w3CCgxOIfLC0GRAYSkzFMaAeqPGAncXw5+G+/z0E6EfoKvjaMjhKTpE8hfV4sxSJPoQuYKQ88weMhmr3VxMMDlplRolNYdBUggQJ/NHct0GAMcuYMT+v/2d5Eh6oDT/8YF8uxViHVzBj6I8E36huxiBjFkUMzBEwjGn4BzyDdAgwBBkCCOOeseXP4277hvagV3jTjW2Hd8HT4DnwHmi+QoUK1kvnV1zhXxUrVlRFc5/njA+MDHgw+cFTwZ2+8TzPenLpD2aFeH43Bc/zBB7wBs/72UAFK+QCWECnKGRsAGXGkrEAjUK3QUFBRLEB/Bkj3IPWkUlRZSm0T796nieUKTy3GCY28V32AT7QJNj6mw5t42RghgFejPyHF/v5M/HoK3gMtAtdBwbGMvI9l+AfPMdY4znYI6vBmTLIgzKJc6cFZteZFYe2oD0OQkDRhx5RztmEzG+wgeZY7YHDATzgy57niTScroTzAFkKtjhCMTjg8chRlHpmAeDv6ETkS8D4pc/Ilzwx+siHa/JgzGTKmEkJjP6ETgWPJz48Hr2RcYUxjrPowQceFKs7omsfOYMhuvbMf1wvjJDGzzxz3et0s+rA5DhmEsvZ834WODeL/1/ev9vKxvjFu4EydCttpy8RWAijW4l/t8cBV7zarFu9HVggbPAk4olF2N+OPO/EPPAkshwgqpPj77QTJYxxgiLwd/K5k9PiJGLTKArZ7WgnihIzGH6j5HbkeSfkgdxFnt4u2gZfaBsavxPwubENnufZ0x5Z8cBMAd/MJhJu/M0SOgxU9qn6n0dNw32eE8+flnvM6LDyhNnjRo0a2SWmUZ+TBoyJy33y5B7XBH5zj0C53PPnwz3SsoSSmf5XXn3FLrO8sZ3R5doZDNGlJ6JZPVCGMmbIYGcUfrFAFQYAABAASURBVK9qgYGBghkR//fiuWf/PgL0Cd4O+uhWSic+AobvW4nv4kh4TfFo3w4sPM8TXkW8V7cjvzs1D+gzTZo0f+jMuNX2o5zhUXdG2s0Rg4fAS/C83jzWrT+BxqH1W09xd8QEXzbSQuO3o8XM1jF7hDPiduQXHfPwPM9uvKeN/0SAP+BMoG/+ifzJk/GA7GWceV70dbw6g0HuzyHgEHAIOAQcAg4Bh4BD4L9BwJUaExBwBkNM6CVXR4eAQ8Ah4BBwCDgEHAIOAYfAf4SAMxj+I+BjWrGuvg4Bh4BDwCHgEHAIOAQcAncnAneHwRARoYsXLuj0qVMuOAwcDTgauNtpwLXfjQFHA44GHA3cJTTAqXJnTp8Wx9D+HVPnrjAYIgxCp06e1P59+8QLmFzY73DY7zBw48DRgKMBRwOOBmI6Dbj6Oxr+Axowuu+hgwd/8XJGoxb/6f93hcHgeZ7SZcig/AULKn+BAi44DBwNOBpwNOBowNGAowFHA44G7ngaKGB039x588rz/T2V/++l/tP2SfRLwBQNrw+fPHmyfY09L/rgdeq3s6YnzewGL/3gpSHkzQuH+L6dZcS0vHjZCljzUrGtW7fq8uXLf6kJYLpu3TodO3ZMmzdvFi9JIaOzZ89q9qxZGjhwoNasXSvK8d9fsWKFFixYoHnz5omXq5w/f16hoaFauXKlDhw4QDQXHAIOAYeAQ8Ah4BBwCDgEriFw1xsMR44cES/q4IVVL7/8sipUqCDeuncNn9vyxRsEeUkNhsPcuXPFS0B4E+BtyTyGZjLTKPMdO3USb7TEWGON3V9pCsr/qFGj7NtawZi3JTI9+eJLL4n8p06dqheaNFH//v2t0bB69WrxAqKPPvpIn376qXipSstWrYTRQF4ffvihNR7+Sl1cmrsCAddIh4BDwCHgEHAI3HUI3PUGAx7mjRs3qnXr1ho+fLhSpEhhvc54qFetWqXPP/9cU6ZM0enTp60HevLXXwtl/9ChQ/ryyy919OhR7dy506YdMmSIDh48aJ8vXbpUc+bM0eDBg4UXvFq1atb73b59e80yyjKGA+lRbsmPuHi4mfGACkmzbNkyq+gSb9u2bWJWAgNn3Lhxtl4ouHjOqSt59uvbV9OmTdOZM2esx3369OkiTJw0UdQXj3pfE2f+/Pm2LijJxO/Xr58mTZqkEydOUPQtBRR9vPRgQ/2o+1dffaWRI0eKGRvatHjxYoEJ5VJHvPjLly/XsGHDtHbNGoWEhCgoKEiFChUSL6phpmDEiBEaPXq0nS0gPnX92mA+dOhQff/997+oG+mHjxiukiVLKjg42BoEnudp5syZNt6ECRNsuzoZw2TixIliJoOXpPA2TeowefJki+N2g+2OHTvUsGFD7d271/azzcB9OAQcAg4Bh8AdjIBrmkPAIXCrCNz1BgNv1+MNlmPHjhWK6UMPPSSUe5Tx5557zi5d6dGjh4YahZUlLy3efFMotuPHj1fXrl21b98+vf/++1bJJU7Tpk2tAfHZZ5/p1Vdf1bz586zyi+KL0o5SjvHx0+bNNv0XX3yhrUZh7dyli43neZFv+aOMV155xdYJZRfFHC98586d1b17d2t0kP+PP/5oDRfq8O2yZXr77betkfHTTz+pZcuWevfdd7VyxUqryDdv3ly0i7gYChgJ5MGMyoABA4SB5CccjBMUcpR2fwgLC/M/FnV502Axe/Zsq2C/9dZb2rVrlyYaw2P0mDHWcAE3jBIMAMr67rvv9N5774nlSGAZagwGlhAtWrRIzAx81P0ja7SsWrlS4IfRQXz6ZcOGDWrTpo01vvyVwADYv2+/NTioL8YA+W3atEmP1K4t/xsuS5curZw5c4o8eJsrS6GoD8bGjBkzlC5dOiVNmlTJkiWzaxnBIWpb/eW5b4eAQ8Ah4BBwCDgEHAJ3IwK+6N7of7p+KIt4oCtXrmyVVhR4lEmUaLzOqVKl0qXLl4ViXKRoUcWNG9d4yIdbhb1SpUqKFy+efRY/fnzr5V5svOoorKzJL1asmD7o9oEwSDAsME7wbufKlUtPPvGEypUrJ2YLFhiP/6WLF1XU5B+1vcwe7Ni5QyivadKksYo2S2xqGqOmd+/eYlkNnnUU6jJlyuiDDz6wxg5xME5Q1uvUqaOnn37aKvV4/lOnTm2V8m++/UZXQ67a2RAU6OTJkythwoTXi1+/fr3atWuntm3b2oCy/sknn1x/jjHBrEDjxo2FkZUte3broa/54IM6bGZfmGEhcqxYsWz9UdYnG49+tmzZ9NJLL6lGjRriGYo+sxXgV65sObuX4fSZM3bmhnYThzY888wzAg+MCPIl7N69285SoOxz7XmeXU7E7Az9ggHBffIgf+4zg0N59O2wocOEMfbss8+KviFu2rRp7QlSlM21Cw4Bh4BDwCHgEHAIOATudgTueoOBmQWW0Tz55JNimVCGjBnFspnTp07b5TIsUWLJS9myZZU5c2Y9WLOmxo4ba2cD6tatK5RSlOdEiRMpf/78ql27tlDKPc+zhgKKaFBQkDzPU2BgoF16wzVKbq1atezSIZY9kTZTpkzy/2XNmlUvvPCCHqjxgN2I28XMLGAEoGAnCA62HnG88njrUYQxHFD6yZf6oPCiKKOg4znnXqJEiWy6++67TwULFFTJ4iXELEaBAgWEodOzZ8/rHnwUa/LA8CGQnnK4Tx35TpAggciTstMbLz1KOWV5nmf3JmQ3RkSWLFlUpUoVaxyhqMeNF9caWRgnvoAAiwtef4wslm+FmlkM0pEX5YBV4sSJrTEWJ87/2bsPeCuKqwHgZx4K2LFjB3sXNXajYG+fosbeMJaoUaOxd7D3aBK7Jti7oom9ocYee6+AGHvBLqjw7X9w8YKoIMX73l1+zNu7szOzs2fOnDl1pk14r3xJ/9ynNNQqAzb6QghkSdFvggu3LJYYglpKKXzvnnvuma0uxs94pzS0jZSGCh3ar1IFgQoCFQQqCFQQqCBQQaCCQETDCwyY03vuuSd23HHH2GSTTeL1fv1i+d/+NlZYcYXMDHO9eeedtwOzOkHB4G622WYx1ZRTxrzzzpsFBIzvoostGnY+6v9G/xw8Kw8j27awRpRI5t5vzD53I4LKcoUQsvDCC4dg6NJaoYwktoIPfkopZiyY8XbFOzHfXbp0Ca5PhBWWEe/FkIsf8A2Ce1lLuOMMKRpqUwgrhAgWiOI2xBIQPCYuLCL33Htvto4QiqaeZurswoN5V27xxRcPwdmnnHJKnPJd2m+//TKD77nkm8qEWZfnitlnPeGihOF/4cUXslUDfB968KHMqHOxwtCrow2uWpj9tQrLg28CE0JKSikLCcpIKSVVciKMEcIGDBiQ7/1xv8Yaa4RAcwHMYLjTTjtly0X7wrrCvUofU0rhvkePHjnOwy5W2n/n7bcKeM8YJRy0WaUKAhUExgEEqiYrCFQQqCBQQaDZQKDhBQZMOw3/qquuGvPNP1/w7//9ttvGeuutl118MP9LFpp4LjSEhrkKrbkyf/rTn4KGHWN+9FFHx0ILLhRzzjFnbFvUZSkgWKy80koZEQgXNNra2nyLLfLOPDTxGF0uMMoTHGqZ1CWXXDJ223XX7Cb02+WXz/EONOd8+rkYcXfilqT/XGr0Rztch8RRzD333PHnQos+/3zzZcuGOhh+VofVVl8tViiEItYQO0Rh1Ln87L333rlsjMI//VeHVYPLFaGlbSGczD///NGlEGo23njj2HDDDbMr1MwzzRyEGDtQiXWwdSmBYrNNN82Wg3UKq826666bXZoIbyw56qaUMjy1P2UhMNnRiEtY2b255porB6kTDjzXH0JAp06dcuzGJIUlhlBx0EEHxbKFcEaAYbnp2rVrfq92Vl999bBDFkGDtebxx5+IJX6zRCUwAE6VKghUEKggUEGggsAoQKAq0vIh0PACAz98TCNf/SMOPyIEOotbwJjynRc0jNnnMsR9hW885ltgNOYbky8uQYAxZl4+jb66mGIoxIpBy01gwOgLTCYQHHjQgSHgF8OsjLJlUnajgunWL+/XFqYWw7vHHnuE+IINNtgguzjNMMMMmeklyHBjwjRjlMUKYKq1SbDBGGtv5512zj776tlKdv/99w9XFgxlRyVh0O0q5Ftnnnnm4OZEoCKoEGL0nzCy++6757516NAhu29h1vWfgCP2gTWCsEbY2X677XI/CF0ELsIIS4pv4frEQkEoKftH0PEOW6VyT9q0EEB8OziB75+Kd3s/+O27zz7BauI9LBDqasd4+g47NbF6gIFynlWpgkAFgQoCFQQqCFQQqCBQQSAqlyRIkFLKGmWMZkopav/JIxTU5qWUhnPN8UwZZf2WUvq+TEopM8vx3T9lMdzdunULuxPR7GNcv3s83EWbUkppWD7BRd6wjOJHmZfS0HIppfzOlIbeR0TuMyFH2fjuX0opBx+3amr1Xc6oX1Iavu2yZkpD81NK2ZWrVavv204pZSFHXkrfl1O3qVWr/Ez/pJRS7nN89y+l9N2v7y9cuQgK4JHS8M/lEQhTStGuXbvsYqZmSsOXS2noPSsPKwzLkXJVqiBQQaCCQAWBCgIVBCoIVBCISmD4tZCApnyVlVeJtdZaK7s2/Vr9aO7vBUcuSASCMfkWAswSSywRLBRj0k5Vt4LAeIFA9ZIKAhUEKghUEKggMB4h0DQe31W9qoJABYEKAhUEKghUEKggUEGgBgLVzwoCzQEClcDQHEap6mMFgQoCFQQqCFQQqCBQQaCCQAWBXwkClcAwSoCvClUQqCBQQaCCQAWBCgIVBCoIVBBoTAhUAsN3426XHacI26f/u6xh+/+X96726q9N8spU5pf35dW+/9qXyrzRuWp3dMpXZRsXAnBFqoVA7T0cHBHHa8s2xO+x/JG18NW0e6n87TyR2nv5VfplEADHWnjCZXk/1trPPa+tN2jQoECra/Na6u+RwWzEbwfnMg/dGFmdWviM7Lk8qbZc+dvYlO27gn/5rKVcfVftt/jmWnj4XQtnZeW51qaR5dU+/7nfI9avHU991Iefa6Pen4PtuOgj2IGPq/bBS/J7ZKkWtuXzkeXpb9mm580B/xteYDBgb775ZlxzzTVx8sknx/nnnx+vvfZaGExnArzzzjvlmOerPf9ffPHFePLJJ8O+/jnzuz/PPvtsvPDCC9/dDb04kOy6667Lh5Vdcskl+ZAwB6cNffrzfwcOHBgOFXOQ2c+Xrko0OgTeeOONuOOOO8IZH2BBCHbq9aeffuo2bEHrUEA3L730UthKtiwrr0qjBwGHDPbu3Tte69MnKxgsLGiDs0bQlnfffTfQEeU+++yzPP/BffTe0hilXyjoKnz817/+Ff/+97/DKe0jLsxoLBoMnnfffXem13fddVeU+F1CyuJ73333Rc+ePfN8cGBl+cz17bffjptvvjm8y9W9efLII4/kcVSmJSaMiTUKDtbC9uWXX44nnnhi2Ce/9957cdNNN+WDSJ/q36JZAAAQAElEQVR59pmwdlnHfmwdkt+7mAfWq7IRcwHuO9+mzHPVh+effz6viQ4ctf6aG8beQanKjE6qx7L4h/vvvz/69euXu/fxxx/HLbfcMgwfP/7k45wPzv/5z38CnZbRt2/fePzxxwP+upfARx54ui+Td9x5552ZhoOdcuWz8ooG4WfAG9wl9Ml4mmP6hUcxl0acI2Ub9X6Fc+buBRdcELfeemv4prLPnhmHEXku8L7tttsy7G644YbA05kPxgIsJXDSDlqOlmjrlVdeicsvvzzXGxFXwdq7Lr744tCOMczwfuKJPH/QGXRL3nPPPZfxH/2BA+aP37V99+56Sw0vMFhoTjzxxIA8tjqFJIcffniYuH//+9/DAgVRIJPB61NMaEzZFVdcEZBIHgSAHAjsbbfeJmtYgmAOhoOwkPTCCy+M0047LS9wZZsQrfa392lT/ueff54R1KT/6quvhrVb/aggMDIIPF4QJ2dPWAwsKBaDf/7zn1EKvldddVW8/c7bWZP6t7/9LWzpi8iNrK0q7+chYJE96aST4tRTTglz1Ry98sor86Jv/lrICGnm9wMPPBB//OMfw3iY4z/femOVeK8QrtBbzNExxxwTl1122XDMO6byjDPOCDh9++23h4Mr4XjP83vmAyLBu4QYnHYujvG49NJLs9CApnquHAbprLPOiv79+8err76aGeOUUm6TkKdcS0u+GyPz5z//eRg84CUBzIGalGa+GUxvvPHGrKiyZh17zLHx4ksvxrXXXhunFHhey7hq09p23HHH5UNPMUTaGDBgQJx++umx1157xeuvvy5rWAJz5TG45sS5556bGWS/MWPDCjbTH2AGd3faaad4+umnA7zwC3AXPl540UVZGANnuKmMbcQpBtEH9AM/AbYEOWcnnX/++TEizfCse/fu8VwhfPmNFtWCTH1tG1vCnveB+V/+8pes7MRg40fsEEjohhu19ZvDb9+IZyt5KrQVsy9f/wlpvv+ZZ54Zjpbgp4444oggSJn/GHYwP/LIIzNfJw9eg7m5gI8zrp6bL+bKP/7xD68YltD5o446KtMUays6Zt095dRTMz/517/+NfNy5gPaRVAwLj179szbx99dKEC0O6zBOvzRNO77VN9vMPiQCZNlgltkHKJWIovBdMiYq8lefg0igNhaxDAMkNKAD4khZZF8tUg5NG3LLbfMh8Jh0ExuE5SUD7Eh7bW9egViCzkRjYMOOij+VggsGoHMFrcdd9wxEBMTX36VKgiMCIEhgwcHPO1JSCgYMAsRQghXaURoFhdeaOEsCNM0du3aNWu+CM4jtlXd/zwEzF+wpR1i2XGPNpj3aj/w4AP5kETngdA82Ua5X6F1NA6eV+l7CDjwEX10kCPljUM0MTNlCRYHsFt00UWjd+/eAXeV3X677cPhkWBflrXAg/nvf//7cHjlCy++kK3GnhsvDIN8hzQ6HHKOOeaIZZddNp8DQxhRrqUlTPzRRx+dBVtwBS/z3llAGMmUUv5kTA7m0cGa1ipn9/xxlz/GcccfFzTa6EYuWPxBW67/1/Xx5BNPZiWENq1P8oyXuu6LosP+Y5RYHayJxtD6hxlz2CmGiUAxrHAz/IGBJTD4dnTA98O5XXfdNR9iuvRSS8ULz78QxgNzu8IKKwR+Ax+BRkfBQ4AjfgBzT4gGBnmuZQI35zctv9xyAZYOTS2fuWpLmwRs9+oPHDQowNk8W6roB8Ha4anm1EWFIINBVrY5pTZt20a3bt3CobW+CT+HBqMVBFw4agxqvwkOO3TWOU5du3YN9dAM/Fznzp0zbVl55ZXDGOERO3XqNEy4+HMhBHfr1i0LfXizsl28GTriEF8Hx/6rsJISIvQPT4cWUdhpz/xzQO1eRVsse8Zq/fXXj+uuvy5q2yzbrpdrwwsMj/z3kVhooYXCQBtEpwuT6C0kCJtJu8ACCwQNgUH9z733Zq1BSikvLldfc01284AgCJ0Jp46yiHFKKWt3by7Mu5iK8847L6addtrQNi0wRODOcE+xADKLde/ePZ9IbJKfdeaZWfKkOXDSMaRG8BFx9apUQWBECAweMiQsQDPMOGN2sUM4CQ3KYQJm6zBbOMncb2dOOOWaxQyxVOZnU1VgOAhgBMAaHGnFLfwODJQsPu+8/U7MP//8Yc5a4JUz/y0amInhGmvwG3gKX7kILL/88hluJUjAGSO/yCKLBNiin7RzrMG0ioTkku6y9KDpLAU777xz3HzTzbHwggvnAyq1h4HAFD/88MNx7LHHBkaOJjalFMsss0xwF9APZVtSwhgSDjAu1jrfJs+aAwZlHg0o3OzQoUNe47hJyHv+ueczA2VtkoeZ0sbvNvxd/OWUvwQGDFNqHNdac63shtGxY8dsPVCuTDPNNFMQCDGtFHTzzDNPUKotuOCCoQ/NXZiGe+ecc04WQDGqE000UWZmV1llleyidPc9d4dvpmCcdNJJM56jyVyi99hjj8Ii8U0GFTx3kCgYtWnTZjgNuQJoCrpNg73NNtsECw3BC++B9hAm0CRMKeHZ2MxZCMYYYQINJSSewjOHluJfuOZpu7mklFIssvDC4QwlvBX8nn322bMHR48ePYIyYPnf/ja++fbbYZ+ElqAf1j0CBUGDhwkcl8/itd122wXlLfimlALOgo/r1FNNFbPOOmt8/sUX8f4HHwxrF9znnXfeTGesrdqTZirWYofBzjfffFkYkDdjkde2EHSmnnrqPK54PDzkwK8GZmXesEbr7EdTnfVnvHdnkoknCZMagfRy19f6vBYWG0w6xIF0tFGeI2gIot/Sgw88EOutt15sscUWsc466+TFjK/aoYcdFmedfXakpqaADA8VixNpHsLtsssu+bA2GghtTNCqKSZo3TqeePKJmL59+0xctt5668CImOQzzDBD1gpsttlmMfnkk8enn30W1b8KAiODAHyxGLOYPfTgg9mto6nAwZRS9qVfcoklM9HiW0yTQcNF28p1xjwYWZtV3o9DALylNdZYI2ihMKAWDnObZjClFJgmFkUM1u2335aFB762FvUfb7kxn6C7GMbOhZYPk1RCAW6Ca2lJwPQTxFhi0VSaae4d6C43C5pwzzfddNNYepml49nnnh3m0mE+oKXcBrgGWLy5l3rHbLPNlpkNQkf57pZyxRhaS3xn+U2YUswqmMBjCdNJkPAMAyRhorgLec5d46STT44jjzoq4zKmR9ueaVdbFG/yat/lmTIYXevshhtuGARoPuIYVcwzwYH1QdnmmnxHu3btwjeW34BJJaByg5l7rrmDZcx3gz2eQh1MpjpgpB74wUfPyzz5ZdIGwYQ7JNrDbQmTe1j37mEOaMt4p5Sy9Uc9grC+UIiySvTu3TvA2xgac0y0cs0p+SY4t/TSS2d8EqNHiUDw9/39+vaNV15+edj8TykF+sJFiDs62o1nm3vuubO7OCECzweGfYu6YD9RIfSh6WDn3hWMUhpqlZOnD2Au332rpqaYYMIJw+8o/qmjjHbKvCI7K4VTSgH+aB7BRH49poYXGEh1zFPMQgb0pQKxjjv2uBwEY/AQTYObUsoDO+Igti0QiVSKMNK8QBguTSuvtFIsvthiwUWkQ6FloTk48MADs0+nhUzbBAnv/OijAQUyfxVTTD5FDPjoo2x9sHAO/C5mQR8gWZ4YrVpFGrET1X0FgRoI0KbQYDGDisOh9YZr3A4QVQs2bSym6Te/+U1wPWBxYBGraab6OYoQMIdpi8xvxL5kPglhFiHab6bprbbaKpZccqlgeja/CRSj+IqGKUbTT1HD4lv70SmlQAfRQLDGkGH0acExXegvxpb2lHKHZpDWdPXVVw/MlHFRl9CGTtPuYsgwSjSx5btYiL1HKvMa4WqN850ppazldy9Zz+AwDTYmi3UMXJdbdtlsyQS/KP4pKxU/f/Q/QQSNMRbGcLXVVos111wzCIKUF+oTBI3LjzbSTB74lrKrfnPPoulnfaDRhuN4ADg5Kgu6NrTnSphVD81G2wka2ivHaqUuXYIlDs9Q1nGV0CQxlebNyt9ZPIyJ+SNhjJVrLunbwd/meBzunjxBuhTfDr8IWcstv1wQHghB3JPAzLeCXwk7AirYgRWFrrgDdKVdIfCBQasJJoiUhgpc8t/o/0b2GHn5lZej3RRTRPv202cXP22bC+gXHO5bCBrmTYfCEuHdLHJiVNAq1gnP0RrPCBHqep/x1Re/f0Ea51UaXmDAvGOixCkwy7IUGDATG5Nl8A0iBgtj4GqgMQHShhtsEL169cq+ibRcJh3TKqsDAguRvvj88yw9QsJyQloQScAsGLRc777zbqy44orZ9LXJJpsEUyIk826EVrsIAoR3HeeYUb2gWUIAvsI3eLPxxhtH165dM0FDOGkwED2+9vAP48qnfoMCh1kZEMtm+dG/YqfB2QJkfloIaLzRBRpTi7MFDOwJa1xBwJugRlNOg4Wm/Irdr7tXW8gt4jTUtZ1Dk2lb0UzaWMwmrTeXDfSXtlUMxHrrrhulX/L5F1wQYssEJ/LRRjt32GGHbD02Zmgv91PuYVwzvMOCb/GuFSJq+9ESflu/JLhbfg+6AW/dW6fs4uNePtevnj175oBw9ISSAfz/r7Co0+CqA49ZzGrblA/O5XqFUaXR5T5CYDZ2e+65Zxhrc4ebGAa4bFP95prAwbpt/Yd3AsDFNrB8wTsuzlxUuKd89un3HgPgDe7ql9+OtpR52jr++OPDbl7cXAThcrvjxkeow7fgPbjWlYKXPhhv7bHGcb+hwDQ38ChokX4MGjQwx1sp11xSU2qKSSadJFgXzeV99t03uDOKfzrm6GNCXCoBt0uhwMV7oc+s69ZCLksHHHBAtsb89re/jTnnmjPgORoBVzf63UYx/3zzFcrcgXnnJXzdrLPNGjvvtHOcdOJJWdhNkUKcyYOFNZ81k1DAO8Q4U1YsWiiNKSh22323OPWvpwarWqdOnfKuWOC///77B+EOzsP9Tz/7NOadb966BX/DCwwWBpI/VwKErEdhzhPpbtGSt+SSS4YFhEDhSqgQNGSSWqQsNMr7DWkxAykVaPRdgmSHHXZY9tGsxQKCCj9Ci1v34p2HHHJI0H5hMLbddttsspxl5lmyoOGdtGd8RP966qnhd21b1e9mAoHx0M0VV1ghLAYIIi0LE/gJJ5wQmKnddtst+yQTEOAU3E8phYWLJYLrzHjoYot6BWbnoGLRKeckOOd5vfJKeUekTsXigAagJbSzKaU8p/klW+BTSi0KHmP6MWAipfRDuGCECF5cYuAwlwLMANhiElJKkdLQtPY6a8d5554btI6CEClhaBIxAwQP/vPyLdYW/MWKhR0zhqkT/EzrN6bfUo/1WU64zkoEJH1MKQXmhkDrHh2YcYYZ824xcJbyCmOJweLqmNJQGKeUFM8JI2rnI0xszvjujzrGyC3rj/eyflKSGTNKDXEo1jZaeMyrtVH55pzatm2bvQm6FBpvjKqdqbgMdevWxUpuuwAAEABJREFULQgM6AJFJY0zi2QpIIhz4LKMNpffj8eQh6Zrd+211w5++tqy8xJ8hcOuKaVhc0D9lFKm/fgSAgTc54pnLA4omFUxkXAdo7vccsvnOBT1mktKqfi+ZZcLbkToLIGAZR0e+l7uuXvssUeOTWpq1Srgm3KYezsrodvwD/4vu8yyOe5GDCC8XX+D9bMARUEh/gz80Zwtt9oyKyJYiliJWMl4lcBzygn35oJ7fKT1d+211o6/nPyXMA6EY3CHG3sWAjOhxry87vrrc2wEZV69wr/hBQYDIy4Aw49R555hYTGAJiqCCSkgmStiZrJishA3RBeTwBfTJOzQoYMmhyWEkL8gojEss/hhksonjfKhoxlQhobrueefy2bazTbfLBAI79YnvxGFdu3aFS1U/ysI/BACNBVwCf56imDSCDKPlvmumIKUkiIBrzFM8nJG9WeUIWBOdlp00SjnpEUqw7JDx6zpcm9M5KEVGk5paFwDhiGloWMgv0qRA0Dh6shggfaitSwCtNZ+Y5ooekp8L+vRPKLfmGBMmMXewk8zbk5gKNYtrBHqo+XqsbxZ+LXn/udSc3xu3cGwYBz9Lr/BWoaRd1+uh9zoaMkxVfzdwa62jrJlAl/whu9lnivaYw30m3BGAec3poiLHgYOU0VYE7S77ba/z3F6yjTnRFmDzpr75j3YsOhiVPnHE2TByr3NTsDZ9xK8PKvFZzwI3JenDhi2b98+Cwa8EuAwnPVcGyMmQgl465Px47JnPOE/+sXaw7pDqFZmxPr1fu+b4BY4rL3WWlkhU/YZ7PFP0007bTQVtJaQCv/VYVVAH9ARcFWnbKdz585ZuYZO4A1LFyK4iuknFFg3tY+PY7kv61N4GCPjkVLKu7SBNwEhpaH0vmPHjnlnK/wmuvTB++/HC88/H3/Y8Q8x8UQTa6ouUyUw1NGwIALMtLRnpGSWjDrqXtWVCgIVBCoI/GoQsMjTzlrgUxq68I7NzhDqWOEs4GOz3ebWVkqF1na55QIzVTJS4/obMK62DV9hhd+O61fVVfuEWYIExvPX6li7du2C4pKg8mv1oQ7eO9IuYPox+ixj43KMJpl00myRJviNtCN1klkJDHUyELqRUsomqaWWXCpv9YqIyq9SBYEKAhUEKghE9nenDR8XmlCax1JT2OiwZu1m6aFFHR+w8B6WnnHJlI2P7xjdd3A94pUwvgSzkfVPH2i8Gw32I4PFyPIoENAGwsPIno+NPGPA8jMu3zE2+tnwAoPdGQQg9evXL/gRCt6yi4wgImZCwUW26OJ/KIlTsCuSQEb+rrWDwGwlkFHgzKWXXZr3RRb0VVum+v0LIVBVGyUICF4T1CZgXgU4bPcHAfzu+csKxvWbKVygvtgZ91UafQjYBIEri6Bx9EOAIZcZO3W4F/x800035cBztEAAKbiP/puabw24yN2kDIpFP23nK2gZfS0DMssvhI+33HJL3i1OHpcJ9eEymKoPjg6agu/ylJNK+u3MBvPAWNQ+V0aylaRxE2TqXlLX1pdou/syGVPB1mWbNgfQJwdv+qayXD1efZOYD7vIgJctw+Xpq6vv5QbrNzihFVyRwMcY2au/HCPfCqa28kRHBOJqp0zGUfCn/fBtG8zNSCCnOu5dR6xn/ohd4PvtPcYDrI23YN+y7Xq6+m7fac9/MBLUCn5ogPXfAV62TAXP2n4r41AxqXyGPoANeKPLgm1tjYovKev63bt373ywa5nnaj7IN4/s+uVefpngrdgEfItAX7D2zLv1FYzd1yZljMf5PXvm86WMB3olT3u1ZevlN7yDO/CyV69eYW6CNdoA78WUlfxd2We0GMzgN7xEo3wfeMFFZ2SBu/LqKgM2fmvTmVp29/K8TPBVffwf2IId10njbQzQD2Mkz9bRysEf7ZgnzYGeNLzAAKkEnRAaIAzkgzCCkCEMImugET9MlyuCce2118a1BXKWyOJqUp540kmh3GuvvhYCcATWaNPzKlUQGNcQwMxwZ3OgIHy2mFnA+ahaKCxmH370YT5MSaCYnRp6F4uRZ+O6by2xfQvNsccdF8cce2ye9xYV+9WXjCoGqVQsOItB0KgF3sLREuEx4jfBO3gmyBuswAejhSlCJ+1scv8DDwyrZqHHjGFQaNv69OkTdtaRMKxo7z979sxbKdqWVtCgxbZsQJm//f3vQaB44oknwpbZtbitfQy03WUEO1rUy7rmDpenq666qszKV8ycYEd7tRMmKJRoYzHWGEQMQC5Yh3+sYYKW4SBGfO+99g7bTOqqPG5AmBa0QkC53Xy+/OrLcJVvjP5y8slBsDjvH+eFw8W0KcgWw6WdMt1+xx1h1xfwguOXX3F5EP4wUZhhm4sYx9r10DgLCjWGcAHjh/Eyh/SnbLtervDHOu/74TM+4MyzzsrbsFvvMZTwF1MJV8t+m+/gCd7oQJmPv8CQoxO+H2woceDVVwMHhnHB8ArQB8uyniulJDyWb9MK+Cm/THDVvOv/xhtx5llnxp133ZnPhjAvvAvDWpYtrzfdeGOeb/97883Qdu/evfMZDtYN31aWq5eruQ234BA4UDTguWyrbDzMf/O0Z8+eeWci/TZfjRtcRI+MlYBj42Y9RLPAnABiPCiPfTvaYutstB2/iI7BB21K5gi4UhaZJ3CZ4GhXKwLaSQVvSChA0/SXsIhOERJZTNX3vLZN7dZTaniBAcIJKLZYmNSIgAVBEJeBglx2MrKrjGSXDUFEiJpnypTJ4jPLLLMEP1i7cIhHgFikybJMda0gMC4hMKRoHDNz5RVXBKKJEMFTeI4QYhYWWXiRoPVAuATr2wIO3hdVq/+jCQFwnaht23js0UfDIqS6PMnvhx95OB/c5jdaID6JBqxRaAKm3rcKpC1hYtMItPRPf/pTDnB9/rnnsnUXjNBgzJOAUQGH99x7b2Zw4XFKKVtqlBc4avEe9PXXgWFQV1If82n3Ku+xja3YB88kdButt/hrs+yTOn/7+99iooknzpsAlPnqYJBZNQQ8zlzQdz7NAqe7du0aNJGYAuXqNQn0JFiBOcYHDcDU2GHHuHw7eHAOoL366qtzwChfdsHfmFS7Ac4w44z5gLZ2U7QLecaNCwtBoPabv/3mm7Cbjx2BFl5k4Xj4oYdj3nnnzbu26QM3J+uid5b1wM44C8DFKKFZAnS5gYzIAJd1fs0rvMAbCNgGh3X/b9146cUXswALn8TXSAJh3Zd9BXOKx/bt2+fzROTzSKC5xl+AAcUl3kGQ7fMvvBDOYSLUYVg9T2n4uB2HzoK1fgiKdjisdsvk/drbcYcdYsopp4pXX3k1MMAY06+/+ToLD2VZV98Gn/XfONnlh/DCZQruE3iUG0n61bL0GV4JRKaMEfdJIUCYJbAJCrfFrKBzCggdVWeKdu1Ceco1cQPGkPAgYJlgKyCaYICpJ2jbltlOSe7BhmLBeH7w4YeazAl8jAOhQ9DzjYVl2RyB73ZqUocFRLvO7zLexu7Zgv5Zf9ffYP24+Zab80F6ucE6/FMJDEOGxAILLpgXIgwVaT+lobEECJjFhobMVmYCX+ykRJKFfCkNP4GNb0pFXpH4ZNrRaNLJJg1E2rMqVRAY1xBADJddbrl8ngcNChyGq97L3QDxt2iVv7t16xaIICKrTJVGDwKDC/oxXcEEbLTxxnH8CSdk5pbABuYWAYwmBgx8KSLQDzun0HphXkfvbc2vtJ2gaDkx73CRry5mH0wwhE89/VTYSSelgm4Wn4eRx0RiSDE8XddbLytgMOgppczkoMl23sFETT/ddPH2O+8MEzg++/zzvNvIc88/H0cfc0zQeGMczAvJ2KDlmAL15XnOZWD++ebPgb7lYU1Fd/J/faLt5rpzWmG9oHnlRtCpU6cwhsY2F6zDP7YCt0MLJZftNMFtjjnnCJptQd6bbb557jU4cKPA6EzZbsq8/SSfasIYpscOSs4owoBheDCdtp9Uz7hqhHBmn3mM8IMPPBiYtJRShhGrjW1xrYkpDR1rdTDWhAR0CFNte0sMOYHlwYceVKSuEpyE03bJgTdnnHlGzFsIRRhxsKJ1lvARtR23KxVNM2FAPrjRaPtWsSLgSgDFW9DmLzD//FmIs/3sOmuvHcYqpe/hpg3M8RprrBHwsndhCejSuXOeB8ZD+xh+zDIL0+233RZgLS4SPmy15VZhHmmnTCmlaDfVVAHXCckvvPhCsFD7ZuPv+7Rblq+Hq2/wXQRO/WFdQGsoySgGuByxdlGQlX1Hm9dac82wqyVrGDpkDDsX8AMb6yEL6CqrrhIEa/AUNwUudqwyh9yjCx9+8IHX5gRWhF0wRuN5r8Bpc48A7B3gmvMKuoUWeTb422+DJW+ZpZcpBLpBeTxzg3X4pxIYCu2KXQIEtZD2mRtJkwYYgkkkbjtGIGokWZMcEqU0/AQecXwRkUEDB+XtuUZ8Nl7vq5c1DATgK9ylUbSQcK9DVAEAbiOuBGMLzGuvvRrMoTQomAXMj3JVGg0IFAIDgr/KyivHyiutFN27dw+LgiBG2vUhg4cEZuH22+/IPvkYU8LCrbfekheJ0XhTsyxKQMBwWMDLD+BmweWES1D3w7oHJrV8xkKQUgo4nFIK1l/10duyTEopM0bu5Zf47X6GQnhj1ncGw0UXXhgEY3OAptVhTuYEjaSy5oq6GGBMA0bjmaefjldefjnMEWUkjLM4Ni4K5guBBlNMc4iBIBQqV6+JcGPfdwwft4hXXn4lrHWsML739X79wvdggNsX8EspZcGMZpuLBc1oyfwTFJx7QeijmQUPTBYXHfW5gDj7habVNp1gQqBiVSMwpPT9mmnsjBWapB11zA91aLQHfDQgu+S4r7dEIMAT8CjgdQC//YYjtMbwDhNY9psC0VzAE5R5GFPfCQdTSoHBhKeYSNvNYnSNyxSFNpyyAexr66vHvYgAS5mJ4b3gwgtiiy23DOcAwEtzR39s39mzZ8/8avxL/jGSP9v9/vehXzTiFJ2YX+/RTwyy+TmSar96Fmu5cUB3nY8AtzD2BAYWATQXXS47yhKPPu+00075rBZKhAlbtw7wRpfQ7E032TTTbJ4jxk/b2tVGvhZj1tSqyW2mR2AND2R43qqpKQgF6IzkWZJXvCe++yc/pZSFQ+1P0KpVhv93j+vuMvRr665b469DBqxNMYArrLhiPi3QpEQIDa5eGHhSozxEE1HzTD0aRNKiiQUZU0rZTw4BRiT5xk0w4YR5H15tVamCwPiAAIbM4kW7Kn6BZoTmygJCO8a0SjjYeONNgubKYuKEXWXGR/9a2jvAEj1waqhgOn7ZFhlCGNcacU+PPfZo1l6jI7ZR/Khghrgb/BJYNMc64KPf4FL6B2OOuKpgRDyTaP9SSsMxiuqiw5Ln6K+FHe3FvM85xxxZSEODuRbdUpj1MWveZRGmDOL2QbuLSfaesk1XDBTNN6YMI6hdTDahAfMk7/bbb8+0/fMvvshMgH6YZxgojKA26zGBrYlBQr8AABAASURBVLg6/tTi8kpLzXLLLxcvv/JyvPzSywGG4AVWX3z5RY5vYhE45NBDg+sNRpQwwPceI4lm2A5UHi02ywIlG6vOH3fdNR/+RbGGuTVm4Dfd9NMHrSwYyfdO9Y3j7MX40b4S2NwbE3DFpGHC1KmXpG+ETrSVFhkzmlIKgmO7grH3bfoKlsrCJWMgT5In+Q3vuMH4TWmz8y67hO/F+KaUYsaZZozlf7t8PPHkE5mRpSVXHk6CDwsFYYCFwhiAJyuZswhY7QjBNO6EbjwMDbh3SfpgbPyGx8ZD37VvPfBdnRbplHdthOve55uMiTr1knwH/DIe+iduQR/Nc9Y1NCCllN0M9dl3wvX777svCBZgZ0tZcGfpQpP87tatW54HrI1NBZOP5lhTraXiEZ5+5ulizKeJ6aebPisXwAc+sGoQjrXl/AdwJ8wYM0LkrLPMErN37Bjy0CsCNqFCf42H7ykVGvpbb6mp3jo0vvsDGUwIB3ZAFNvqSZDPMxI2E6EJxIwNIZ9+5pmYbPLJ4567784n/slHYOVBJvd8PfmGH3jAAXnSje/vqt7XmBCAw60LIdXXr12Ysmn/EFACLM0VTRGiZoHnYmBhxxRYbCxa6lVp1CGQUoq2bdpEU6tWgW6IW0L8LUoYUP7uFg+LAY3kpptuGhYjgoQFXf6ov615lkRH0dOUUmCe+MpbVO00QsiipLFQ+jqWBQsm4bbMg9PosHtuRJh7QgcmAZPJNYjvNXhiwp588qmg5e5eWHsIZ5hbsSNgb4y8R5+06TclkLb466+2+upBiNGufqL9mGwMd4/DD88BoRjmDh06RP/+rwchGyOhnXpMBKhrrr46u5aIWTjqqKOy1WafvfeJXXbeJbhdUIQtsOCC+VRbWlfMDc3/Z59+GhQJBA07+dDWoiOCaXPebbflU4TRGD7fN/z73/H0U0/l2CnvATv4TbE204wzRutinoARQYz2HA6YC5i3gw4+OLybS9Pgwd8WDHKfMAbGSZ16SZQD/OPR0P79+wcc49611NJLBwYVPoMdV6A2bVrn4HECRtl/8wCD6B5D+fbbb2ctNv/3Rx5+OD4aMCC4EGlztVVXi/323S+27bZtcP/aeOONAzzg/hNPPhmUQWDmwC/90AaFhPGA82hM5kEOPDDHWJT1vRvPU+I/txxtUXx6pp1//POfGWesEeZd3759Mn6op0y9JPiFEWc9g09HHXlksAYSZAmi5jWrFSsWwYkFCL0RbEw4xbiz0NjJ7vrrrssWSePKimYcZ55ppuxSh7m37a+5f3iPw7NyecMNNswCntg0whyrG1juf8D+OQieu5h+GO8ePXrkjRjEDFp70SnvEKzOg4Vl7/V+r8fnX3wehOd6ge+I/Wh4gQGhtLiQ+gw8Ux4TtAlIYkQA7FhgwJmqCAwLFcR1h+23D2Z1hFN9Ujm/uFtvuSUvVkzAPXv2DKdjWvBGBHx1X0FgXECAawycxXi1KRZo+GnHE3iImcWM0ajsscceUS4Y/FMxA4jbuOhTS26TEGb+L7jAAvkzEX90hLCGVlBEWGS4bBDWFLJYHHbYYTnoLqUkq0UnDDUFCnpq0ca4UrCgsfATfFIaCgcCAUYHU0rjCTDuwYsghuEi4KonuFCcDtcDGlYWhPbt24eYM9pDC7IyJZ5rq0yYUT79xsKCzr2IhliAqEBI78G8YgLMD7uebLP11nFYoXUXLKmfd955V3QoBAfPy3br7cq6ghnCoFvDKLN8u+81Fnbt2f1Pf4qJJ5ooCFeP/vfRwCByESpdktATQhQYYM4IA9bCziuuOOxzU0o54JnW2w4wnnNBsvZhVAljBGsVjNF2220XM7SfIYyZ8epWwFYfCdjvv/9B9OnTN8wh5espYZgx5HfeeWdm7OGwWIK555or7yAl6BtuwlE0mMsLwaD8BnW5amH8MfcsE2DGqoDpPf6447IQsvEmmwR8lPAj4oDgGnxVX5sEWMyvHdrAW/xH+R5XjCnBwxgbE/gsX+rcuXNo02/zyniYp+qceMIJsWPB38ABTDKhmBa/jBNQp14SOFIGGA+822GFkoASjGYfLPco1jn4C76TTDJxcEsEd/SI4Adu4ADvrItcl+C5uaJdc8U8YQlgSSTMHXDgAXHM0ceE91hPjb+YLLCCwzYXQO8pItB8vCDLxVlnnhXoFDqofX0xl7p16xboTa/remUhWd/rBb4j9qPhBQZMlUFFCBAyE9TglXnTTDNNWBAgg+Q3YquciQwp5EMCBEKee+VopiD0iECv7isIjCsITDLJJIWpdNqsifIOzBKmlvbLFT5apBDBlJIiWUviGZzOGdWfUYYAhgjs0BGV3KMd4MsPFrzRBWX8VkbyfKZCe5XS0DGQ11IThhz+obHggzFBH0s6WYt3yhK67D7y7nvvZZCALZiqKwNOq08Yg+8pDXUJgdcppazpZXVQBi1XZ8QkH82uHRNljAu67bcxsyakNLRNgg16rz/vv/9+YPQIF/qjfD0mfRNATGsJ3tYnTE7ZV7Cfasop8y2t+IILLRRc5bgPcdfwveAI/sZNfe1I4J0rFn/AEbzK5+qBb0opWzTANKWhuA722m/Ttk2mPYSaxRZfPFvotIM59bweFRgpDcWF8jvBwTyG24RIeAdu4N7U1Cp7F8gvQJT/wy/8gxt1CBZcRJU3TtqTaLabmoayZ8ph6lsVVkwJXCefbLJQprYO+Gu3TCkNnReEAJsImFvlM/PGmLqX7xvghfZnmXXW6LToovmQxJRS2OVs6qmnGS7WSL16SCmlgFu14wF3fJNvNB5w37dFpOwWZwzASh146jlYwGfwdG8MwMTYUbaxFnPX0ia8VBceGyPjgcanlEI7iy262DBcTillOOrHbB1my/ie0tA+GxdzS19ZAuHBH/+46zD3qajDf0Mxsg47VnWpgkAFgQoCYxsCVXv1DwEMF41gycjWY48xDra05OpQj/37JX3C/Px5zz3DN7Ey/JI2xrROSikwcdz3wHhM26v3+jTbXOUwjfXaV8wxbTimuF77OK76RYDiDsbaQFEwrt4Dtqyhiyy88Lh6xVhptxIYxgIYBcQwn/9aRHYsfELVRINAgM+nILcG+dxf/TPRBPB2/dU700w6gHnqMNtseackcAM/eDs2uq+9UW1HXM+PlaWxxNj+2PPmmk/LSrNKeBibcB8deLRr1y5rZVMaapH4ibrN/hEtdceOHYOFYcSPgfPGYMT8Mb0v2x3VucDljxYdTozpu5tjfYJrOSfGVf/RExbplOob5yuBocAAk9I2c+XBS0VWCIixBR2fT1vLCQQiFDBL8Qm1+4Fygl34yPEr/MtfTslBffKrVEHg14AAc77YGkFa3i/4li9yeX/LLbeEXXw843rAT5V7hfsqjT4EBPGCNx9XC7BdOe66665sxnePTvDXt1OSJLjwiSeeGP0XtdAaAsL5gfPlBasRP1OQLdoLdg6REncgUBDuYnzK8gJ1BTfat17smN1QymeuaLx2+BI7Ide4yR8x3XHHHTnQ19hdcMEFIbh1xDLN6d53cKfgM81fW5Bnbf/BRUAzn254DH895yIBV23i4VyBU045JcQ5KSNoWRlJeYdR0Y4KPJdXmyjTuG5p3449xrH2ufrmh01FrKv6a2z5pOtbbdnm+hu84KUYMjEHtd/he/EQeAwxNyXe4jXA33gJwuU7LzbCfKit77dgX7DV/oj4Cv7yjKHTym0xbGwFpKunfnNO4CeoHF2Ao77TPB8wYMCwz7KDEd5O7JE57b58aO2Dv+X6iA/E86Exn3z8cS6GRqlPgWB9FfOQn3/ySX5e+8dcMg76ALfB30GU8nr27Jl3f5NnMwFbnxvXvn37hjERa/hjdKn2Hb/m73ErMPyaXzYa77b/MeHAAFp4VLUTEgIp0IgWQNAQZLBtol0KTFyEjakOAoqIv+76XgHZTHZtVKmCwPiGAOKJKbKwW3BtDynwza4zGCw708BPxAxOC8iyOCO847uvLeF9GCAL1eFHHJG39rSoWFwE7YKpxcKiz7Rta06MlZ060IyW8P1j8g1oLXppFx2L8rHHHZu3MizbhL8CpAm9/Kht84nJsbhT3JTl4DVh4rx//CMfwOk5/K59jikVzMhn+Morrgy0XL2yjLHCzPEpt1tKSilougVV1/siXn7DyK4ff/JxHHPsMXknHusc/APvsqw1DKPCJcK3XnrppZmpAU8CnHxMFQbszLPODIJdLe5i8jHDYOWZtREsy/aNMQaLdhpjZgxqn9vZCrPHrxxDfM899+Rta40XJqpsp7le4SmlDKadFhmPgeksvwc+gxuYPvnUUwEGaEjv3r2D4gFcwMxYmAcOfkTLy/rqCbAVwMsSYHydK1I+1xb6TxA2L4yj4F3tYZ4xr2XZ5niFS76x/Da02HfJ8z2+zyFstrgXn+CZ4GJzH+ww8tZBMAUjuyqJF/H7+BNPDONnzTRn8H7o1YBCkLBmqqcd75GMmc0ZwJdAYYMAwp55xZ0JP4meOQjxyKOOynEOnluD1SfYC5qubVN+PaWGFxgMjsVdNLzt5c4///y8SwTDEDOUXTJEw/PjoylIKYWJbxDP+8d5+YwF0fl2QzjzjDNDhHtzXmB8V5WaLwQmbN06BGpanB05L2Cubdu2kVLKWgyL/6KLLRq03Iis3WQs0gSLn/vq6vnIISDQ7aUXXwxau5SG0gduNRYzizcm1e+rrroy7/1t4RHgNvLWGieXMIUJ6ty5c95NrkvnLhlPSwhgZm0bKeiQphtDJNBZcK6gREyospgDW0LaqWbueebJW1CW26d67h2satoR0Gi3F8yDZ2XCTJ9+xhkx62yzRrspp8xrgJ3vCNfmR1muuV2//ebb+HrQ1/m8FTsSmfOYoPI7BODuseeeYfeeDh07BAaGlht94LeNlhx44IFhHZx2mmnjuOOPC0q0sj7rgfE74IADolu3bnm7SYxY+Zzghv4IZDd22rbmls8xYoJUbQNqfD231ppTLKNlueZ69a3mu0DZNddcM39GLa3F0Crj3ITfLr983tPfGGFYwR+jCX/timT84KP2ckPFH7zGK6++GnahwvxyHTIm6E3xOJTHt4gLMme0SbgTO4HpBW/lmmtCA+x6hFG3Kxe8cTaFoGbfBNcpArgPwivbms4919wZLrZfJShww0spZdpDICA0wMdXX3kljwdlhsMlbTsOtw895JAg+LES1J5twcJmNzF9MdaEYcIB/GZB0y6cNuY7br9DUOzhG63JxtQWtncVgqLx0vd6TA0vMFhsDKpFHcIZUIdzWPBNJlsjkvqVIQwYREiqHq3XGquvEXzc5JuQe+yxR47ad1+lCgLjGwIWnyWXWiqfXml7PAST0KAfCFyHDh3ywUp+zzLLzIEposmr1XopW6VRg4CFeepppgkLERcCFh60A8wtJhYkdIHL0muv9YmuXbvmXXws6jToo/aWllkKI8RSiyGnxQOjlNKwjyVQUNpg/jFGmCfBmfT7AAAQAElEQVTlzzr77KCBxowq/PU338Sgr78OuA/+zPwOzcN4wW27LX340UfZFU8+6wLNrrqSftBALrP00rHFFltGU6tWmXmgGLJdIkZB28o2twRmNKYsBtxW+MvTWkdE/hRMlC2BWcUefeS/Ycci615KKf9WCDNjT3rb266y8ioZNvIlYwPmd999dxgvZeE9y4KdrggLrGvcMYyxgGr36kr8tglrtOjGilAB7vr18CMPZ8FNueaa0IJZZpkluILSSLuH0+X30EYT2liEMbDzzjdfsFpiIu3KZfyU5+Ji/IxPafV56+23A/M56SSTBKYYTSdgY2pLfEWfvAuOw3tCBTiDb0opWoriwjezLghQXrqYxykNpSPgYK47RwXNNQ/gJ+0/mOHv0O8hBZDUtZ2t+X7b7bfltRFugjHBGdzMJTsnEczwgB9+NKCoOfQ/4Rc+uyOE/O/NN+PNt97KuxaaB/jHjz/5JLS1Xtf1QnluaJQYxtiuSd8WtIyLmjbqMTW8wAB5TEZnLVjwDZZFxQEtBp2Jj4bFYUEWlXIQuSmZuB9+9GGZla/28TU58031p4LAeIaABQJe0rJwhWEaTSkFIdeiTlPy7jvvBvcYCwzcttDD+UZnYOMX/ANviWaJWyL3C8wS+lAuxpi02267PR9oxY+c5knCBP+CV7aYKrSfNIIWbZYui3Stdg0cLa4ppbCTjAPIKGQ223TTfMASJgEwJpt00uh+2GHBtcUuP7S5tH1/3muvvOifftpp8cXnn4edd+xsZKwwC6XAYf971iH39/3nP/Hof/8b/Iq1TTtII9xc5wYYUmxhFLkOUQxwj/FtUkopKxBoOp3SfOlllwV3FTSE0KsMRokwZ795DK+8MrE8sMpwa8IAEQYuvOjC6Lr++tk91+F3FGoYI31wRok1V33M3CWXXhoOfTN2hAnuM+aTtfejDz+K5gp33yfhBQjEzjnA8GM20WHPJG4oFJRiGI4//vh4+KGHAsMKzoQJuOce3opBULZnz55hO9987tOtt4a2n3zqyXxInO2L0R70Xvu2HLUGgL/xJ0Sz3BFSML/9Xu+nWLNPhFbJHAe78oPgksSyAv9YGcUwnXLqKWG+W/fwfE88/ngox6qg3KKLdAqWSAofvCDBTYLfKQ0VRgrJuVhXh75J3eGeFdmtmpry+QrGIqWU20/yC4UES163wiKnDqsGvGjbtm3edrWWBhbFR/H/+CnW8AIDP0Hm6R49euSDTBBO2gCakgkmnDDvIW1ikRzLBR4CQcqVuqyUD29DhN//4IOghbH4QbLxM3zVWyoIDA8BhMsia6HAvFqAaUngpMWH2x1GFvE75pjjwkKEYBEaLCbDt1bdjQoEaKBSSsHsjC4w9dM+EchojWgLnyoWdONBAcFk7Tmt16i031LL0E5jXOAd2tq2ddsomVTfzHVCPviirRK40cBipuC6xRVTTEPNtZRFzXNt77LTTiE2jam/ZPwJKdqA/36ri8n6v3XXzSfbujdPCCPax/Bhno2rPjW35BtbT9g6MCS0mJgS3+QbwYqlxsGDYOb514MG5TEAcww9GBA4jAW3lij+eYbpR2dYI5ZZepmgPef2Mf8C84eD2hyatftuu2WGX130iOCsjneZE/r2YbFuEgqNh/frV0opx6IQNJor3Asw5f8lDOF569ats7YZ/AlXEhgYE8/xGJhLMHJVF6zBAA6CocQCg9aIXaBNN0cIEGIhpp5m6nwWgDywJOgRRLjswW1MMlzwXjwON7Pc0Wb8B45yoeO2xZrjU8CQZcEztODLr74M8x5cJm47cay6yqox51xzRt9+fUNwszF57bXXYttttw14uvkWW+QTnids3boQCpqyJUfb4Ijf43HSfvrp81kY4Kxt76GI8F5l0P655pwzCIXW4N69e+eD2cyxfffZJ+8CR4Gkj3hK4+032uYb6jE11WOnxmefLOrrrLNOPlVyxRVXzK4FCKnJzDxEA8s/ky8yLZeJzNcSgbMzEv85BPeYo4+Oiy6+KGuxxEOMz2+o3lX/EBhfPZx4oomyS1xKKfi80sgiZDRTTKKYIwwAP/DVVls1VlpppaxJsWixSIyvfraU99AQTT3VVFmTxNWDUMAFycKMKercuXP2C7fgc1tyzw2M4MYsbpFoKbAY3e+gWUY/uRLQ8K+/wfqZoSrb4QIDJy3ycPjWW28JWlbxCGCIThMUXDFcgksFFWL211577eCah6Z7ByaWZpcmm9sGn3qLv/rcPPglo/VcEqwHXFQt3rSWGAV0v+xXc7piwuebf74Q7Ekpxvri22j6MVlcU7h5GYMrrrwytt9uuyAYfPrZp4ERgp+YGUo1NMK3Y65Y5Pu9/nqhZE0h8FlAJ6bo99v+Puaac67g3sGlhpuvuXDiSSeFHXpoesHSb/PDeRuYLIGh6JI19ptvvg590reUklc22wQv4eB111+fhVcCQJcuXcJuPNyfwbpDx44h2JUrHbiJZ0BXXn7l5Wz9wQhfdtmlceSRRwbhCkzhNFqCuSU0X3LJpcGCMc3U04b3UVoIQFceM2teCK5lXYMD/fu/nsfX+5stcL/rOOEArrKeg5tsMIHT8sUTPPvMs9kCybq2xZZbZAvNoYccmpU8K6+ySoAlRTG+jwKDRQZNmm3WWbOrI1zlOgR+p/711LjxphtzXM+QIRHmEpqCxoA1wY2VzvoL1u3atcvvJjBss8028cyzz4a4E8oRZY0NhR6BhWDDDdI31GNqeIHBVlsmYDk4iJRFn3sBE96OO+6YA4oIBRYh0jnzOeTBfDElcv/YcMMN4/jjjg8B0iXSlm1W1woC4wsCGFGLPi2FhXnXXXcNAi+XOotz28LsiSGyGwyhV78sOt27d88B++6rNOoQoDwAYwyVWhZyCxVmuKQTBAhmbgKFMsZgl112ycqJlJo3Q+R7fmmiLaUpFXArAJAlAM6W7WHq0VsuQ4IQjzjiyFh55ZWzqwumCOwJYYQJu9UZB3QbrNHxsh1XbaHVXBJYeTCzBAXvxtRZvGmAN1h//awhR8O5KgwYMCAwCdqoSc3mJ5yjNMCIg6/ASwIQeIIRZpTFi/sFoWmDYh1DD2adZdZgfTceaMfWW289bLMPmv+11lora7IxRMaQAEdbSsirBY6YKYLYeoUFxzppnLgbeZ/1E/OMPllb1Tdv3n77newW5R21bTXH3+Y6JnGH7bcP34PO4h1YBuAkWOy9117B3Ys7jWBaMIOf1193faDjvB622mrrjJdgxFpWwgLOcv/a7ve/D8LYwQcfFPzr0SG4bo7Z0tY8wcvAfeP38MOP5Di3km6V7TXHq7mL78KDlf2HW/K4PII1uGLgCc3WSPOb5Wb66aaPPffYI8wJOMktHS2Cp4QINMIYoQUsO2C5/XbbF3X2jPULWmEN1S5lnHElABAczDOCORplflAum2cUdN5PuWE+cCfr2rVrTD7ZZMF9b8EFFwrjX35HvV0bXmBYcMEFcxBiOTAQgNQNgfhU0sRCOIMPwSAngmohUwdimpyIqrY8l1+lCgK/BgQQKAQHQfR+2g2MgUWkNHm7uk9pKLNq0VEGYVSnSqMOAbCzWFiE1TL/wdJCZQHx3KJtYfZMmZRS3lIPnUlp6BjIb8QE59BXtJYVphYGmF2L/mOPP553NaF5Q2e5vqDTmLEySFZZdBi9ht8Y3dq20G6Cm/rluJgbGF5jVJalkSWAuKc5xIRpz31zTCmlzNjTvvp2eAkP4SxXW3TCb886deqULWXGAXP76GOPBc2qciwVJUzBC+5icrRlPNTXzogwUqdDhw5hXGjOtY3xMgaYYfXLcTU+ynPnsMbKH7G95nhPICUAgJHvSikFph9epZQyg4+JBCP0GwwIviw5GFU8BtipX+JmLRymmHzyvAuW5/DXM+WMR0op5GnfPIPz3MnAGFNsHinfnBN4gaU1rfwOOEZ4RZfhK3wDH7gK58py6MIcc8yRD86Dp2AkGQt0HF1ZffXVI2v/v/wyzAXPO3XqlAVo84dHCRqvTXSeIIhf9Ezf8JLaQ2u823iYj9qRr5/vvf9+sKb+sVAk1fOYNLzAYJCrVEGggkAFgQoC9QcBjKtF1MI/vnsntocFIqXGE+owNMcec0xgMMcn3FNKgbFjgfs1xnx8futPvQvDL0YB0/9T5X7JM0IJSwNG9ZfUb6Q6GH5WL1YeAu64+nbjLQ6IwDGu3jE22q0EhrEBxaqNcQqBqvEKAhUEGhMCFmzWXNq68Q0BWkPvH9/vrZf30a7SwI7v/tAOt23bdny/tu7exxozLphUWm5Wj0bG7dEZbLQHDRqX8GIF8Y7R6devUbYSGH4NqFfvrCBQQaCCQGNCoPrqCgIVBCoIVBBohhCoBIZmOGhVlysIVBCoIFBBoIJABYEKAr8uBKq3NxIEGkJgsD3eu++8E6++/HI4mKNKr1RweKWCQTUPKhyocKDCgQoHKhyocKBl48ArBe/b77XXYsjgwWMk3zSEwABCE7ZuHW0nmij4RjZSqr61bTXmbSsYVPOgwoEKByocqHCgwoFGxAFxQW0KPiDSmG3g0ISZbukppZQPs5pp5pmjSvULg/YzzBDSjDPNlK/lWLmfvn37PHa1v8vn1bV+x7Qam7E6NnkOVDCtYFrhQIUDFQ5UODA6ONB+xhkLeaESGMZI3nEioJP2nPjpFNCbb7457H88Ro3WYeV33303/ve//4WTCK+66qp48MEHw6mT9dJV/frnP/8ZTl+95557wgE3jz32WHAne+qpp8LJlU4MVe7f//53vFyY2Oql71U/KghUEKggUEGggsDoQaAqXUGgeUGgISwMPzUkGE8n7l1wwQWBYd1qq63CaYofffRRZlYJD35//fXXuRkM7BdffBEffvhhuObM4s/AgQNznvKDBw8O6fPPP89lPv7443z98qsvQ1uY3rIdbajz6aef5vcVTYV3DRgwIAsuymlLuS+/HFr/s88+y+0r67e+uCorKSfPewkFDgTZfffd4/LLLw99uvHGGwMz7tk333wT3lWW1ab+Kadf8pWRX9tumSf/55I+lW36ft8ir6zntz7df//9Ycu3Xr16he9x6qK+uVff9ma2+QOrK668MsO0bKO6VhCoIFBBoIJABYEKAhUEKgiMGwg0vMBgb12nWB555JHxr3/9KxzQccstt4STEB9++OE45JBDYv/998/MNqYV8338CcfHnnvumbXg7lkpzj777Pjzn/8cBx98cPznP/fGhx98ECeddFIce+yxcdBBB8VRRx0VDmJR7/zzz8/CxYUXXpiFE3WUefzxx7MF4Nprr83vPOCAA7IlgHXg7HPOieNPOCH222+/0FcnD77yyiu5D7V5nxbCxN///vdcf/+i3zTzjzzySNDa33TTTfH+++9Hhw4dYtpppw0a+8suuyz23nvv2G///cJzeTfccEPu12GHHZafqfv222/Hqaeemtul/b/77rtjVIWGzz7/LDD4J554YrDknHXWWeGb37B/bgAAEABJREFUSpQmlLB4rL/++mHfaScdLr744mFvYvkEJqciEhgIFEsssUS8/vrr8U5hNSnbqK4VBCoIVBCoIFBBoIJABYEKAuMGAg0vMAArRtQhNQSHlVZaKTPtzz77bGaWH3300Zhkkkky8//888/HueeeG7fccmvMP//88cCDD2ZG/Oqrr45zCoZ+wQUXzAz5McccG88WZQkGd9xxRzgkhbb8tVdfC4dzyH/11Vfj9ttvj549e4ZT/p544ok45phjgtBw9NFHB036Sy+9lBl0gsH1110Xd915Zyy66KLhfQ888EAWYtSfbLJJMwP+3vvvBe27ejPMMEPccustcdppp+UjzDHi4gO0e9999+VjyHv37h2HHnpoOCBm0MBB+Xufe+65bH2g8Xc0OkvEFVdcEb7jlFNOicFDBmcLCIadhQL8MPQsEt5dJhaC8vlXX34Vd955R7YIrLjiivkbvYdlQX2uUu+9914sssgiWWAAD4IOeBLenH7IEqSc8o5a9z2PFWPjvkoVBEYBAlWRCgIVBCoIVBCoIFBB4BdCoBIYCsCVjGvxM/zG6JYa/LcKzfqTTz2VBQFMPX96DCwXn39df32svfba8cwzz8QinTrFdtttF7vttluoiyGmgV9yySWjS5cuWWjYauutY5VVV82BJ1yYvh38bcwxxxzBJYp2/d57740XXngh13/q6acDE92nb98sDGD011lnndhggw1i6qmnzs8WW3yxHMx9wQUXZo07pr1tmzYx3XTTBavCu++8G9yIMNjy9IXwworg/cr4vc8++8Qf/vCHbPVgTfj6m29iiaLfW2yxRXRatFOOfZhtttli7rnnjiuvuDLuLfr5xZdfZFiB2ZtvvhknFNaPvfbaKySWFlaQN954w+NcboJWE+S+L7XUUvmbwSY/LP4M+Pjj+GrgwLybkWj+HXbYIVsipppqqtynFwvBiaWGJUZ/27ZtG21at46+BWyK6tX/CgIVBCoIVBBoKAhUH1tBoILA+IZA0/h+YT2+T8wA5pZm/qKLL8oaf8w1l5gFCkvCuv/3f9F1/fUDs8va8H6hDWeB4K505ZVXxuRTTJ6ZaozzU08+GVxqpimY+iHFx6aUir+RmeZJC0sFYYRQUmQEdyh1uD8RMmjWWTq0t8Jvfxv/V7x3k403zv1RT3mJRYQg0KqpVWy00Ubxpz32CILFOWefE9dcc01ccMEFsWohmHTs2DG7HXkfK8AHH3wQBAUd4toz1dRTZWsBIYigohzBwDuain63atUqxxTI9/7OnTvHEUcckYWUU085NcQXaKtdu3ZZcNp8881DImh07do1CzaeS9oY4keR/C4uBQiG5rSecMJo1dQU+phSyhYRgsEll1wS22yzTdg7+IADD8xCG8uFchIrg3aqVEGggkAFgQoCFQQqCFQQqCAw7iAwzgSGcdflsdsyoQCDzDVn3XXXjRdfeDF23HHHWGWVVUIANDcYrkOCdaeeZpqch1Hebffdsqad9n7NNdfMDC+rw2lnnB6sBYssskjM0L59dkHKAkRRF5Pu95RTThkTFExyU2rKgc377rtvcDESP0FQWXmlleO///1v3Hb7bdmPn5BCkKB911ead/cCm8USPFNYI7xrjTXWiI6zd4z2xXsFELNKqIPxn3322eOaq6/O1hCCCTek1VdfPQtB4ifEJ2Dyl1tuuZhi8smDEJBSyv2fpug7AYVFggVCu96lX0ZDW+IKCBRlEnMg33N9ZtmYcIIJsnVFPrinlDwO7lNtC6tBv3798j3hhEvSPPPME+AxyaSTxLWFIMSyQkgQ/2AMfvOb3+Ty1Z8KAhUEKghUEKggUEGggkAFgXEHgYYXGLjZnH/++XHmmWeGYGEBuRttvFGOW+BeUwYqH3LwwcFqgMk+/fTT48gjjszxDKuttlosu8yyOSAY433a30/LLkY09Xz+acgXWmih/BzTvtSSS+agZc/tmsQl6cBCe/7Xv/41Nttss2xNsEuTQOajjzo6/vjHP2YXHgINlySMt+eYewKOIGLuRAKsNy6sEcsvt3z+Dq5RvklZlgbWEP1ZeOGFc1yEunPPNXd4r2Bk3ykwmzCiHW5BmPgdd9gxxzaIPeB2tPPOO4dgaAHZGP9RQU3CDWFITAQBhlVEP1IaKjAIwJ533nlD3ATrgzTffPOGPhBKlF9m2WVyUDmBizWE4AB2Uf0bHxCo3lFBoIJABYEKAhUEKgg0MAQaXmDAgGOGV1555WxVEGg7UduJMkqwBKywwgohEJq2m6aedl3gsfI03DTl8gRBK/fb3/42MN0Y22WWWSYICdqhKZ9sssmCtl59751n7nmyhl+5ZZddNmvzaeMJEzT12mMNwByzWLBmeJf6M888cw4Q5ialnKtymHy/9ds79dF755tvvvwdtPkEGO/wrg4dOuR8MBDnIA8jXn4vgSrDZKKJwtV3L7/88tkqkFLKcPq5P/qsPd8Mht4NJmU9sNpwww3zGQzcwlhiFlpo4VBOf+aac67oul7XIGSwdIgZWa0Q1AgiZRvVtYJABYEKAhUERgUCVZkKAhUEKgiMPgQaXmAYfZCNnRo05z169Mg7IxE6xk6rzbcVVhBWEkKRryAouJapvCcQbb311jlGg/BRPq+uFQQqCFQQqCBQQaCCQAWBhoLAePzYSmAYj8CufVVKKbs9cetJadQ09bX1W+LvMkbhp76N4MA6wWrxU+WqZxUEKghUEKggUEGggkAFgQoCYwcClcAwduBYtVJB4McgUOVXEKggUEGggkAFgQoCFQSaNQQqgaFZD1/V+QoCFQQqCFQQGH8QqN5UQaCCQAWBxoRAJTAU425XHvv7f/LJJ8XdqP93foPtVm0D6nwD11GvXZWsIDB+IFDity2CS3wdP29u3LegB7b/lfxuXEiM/pc7gwWevv/+++Fae8ij1tBduFzmo7tot3zPbYzgzJmR1TcXPv300yif++3Ay/fefy+fA6N+oyXw+uKLLwJsJDB56623MuyddwMeYN23b99QroSdq+2tPfvqq6/inXfeyUl76pRJG9p01pExMU7ulS/LNNIVjOEcWEi2R3cvH+47mwlcwddzV/wJGLuX5CkDtrWwk2fsPv744zyersqPWK62TnP/DW7wqRa/ar8JfUBHwAUclQcPsOrfv3/Gc2XgNlhJ4At22kG/33777ajFc2XU8bxM2tWm8fM+75Cnb94tz71kvPX3vffey2dluX/99ddjxDbLtuvlWgkMxUgYZFuL7r333nnwiqxR+t//jTfizLPOineLQXeAGwQYpYpVoQoC4xECFmbb5h555JFhO9xHH300LybjsQsN9SoLzLXXXhu2MrYd8uWXXx4jMlENBZDR+FgL5h133JFhhybbGtpiWzZhsYW/l156aYap+yeeeCL233//sN0yZrRXr14Zz20DffbZZ4dFuayPYbC9dPfu3eP444+Pf//73/nQzXPPOTcs2GW5RrlihJzBY0trDA5m59hjjw0bctja+8knn8ygcE7QP847L1555ZWwOcVxxx2Xt7nec889w8Gj//znP/N22+B67rnnRslsGZ8+ffqENtEfW4jfeNONQZA+5thj8s54+QUN9IdQAMfh3zHHHBO77LJLXHbZZfkQ1d69e8cVV1wRd999d8BfcNtjjz3Cdu/GQnnpT3/6U9jGHT6XoANn8LXtuS3SCdXgbA4Y17JcS7sSZMHJN/t+cxqMfSecfvjhhzM9gX9gjk8DS2vh0UcfHd0LWqDMf+67L29CA762pQf/rwcNirt7947rr78+0xt47h3q3nvvvV4xLJkH5oyt7NF+h/uiPccWc6VHjx6xX0GjvNecO+nkk/P2+sbQYbuERvMQbRvWYB3+aHiBAUGzlefTTz8dDz74YPznP//Jw0Sad3gYQeChhx7KJyRbzOSZ0M8//3w+VG3aaabJC5VJqS4p9NFH/xuYBO1BWBImQoAoOJBNO/kl1Z+fg0D1fAwhAP/goUPxtt9++7zNLzyEk2PYdFX9RyAA1jfccEPYKvh3v/td3HTTTfHyyy//SOkquxYCGP7HH388bAax9tprh/NibIZQliF43XXXXXlbZ2e6YJgs4mCMSSWsPfbYYxnP11tvvfi///u/cAhlWZ+W77nnngsHTRobW1rbuhpNvu666xpKkAYLzE3Pnj2zZcBaiJmyoYTDS8HyoosuCrTi1ltvDVuH2ybcOT0OJ33ttdfy1t7G4Kmnnoott9wynyXU++67w5oK5tp85tlnw3rqLB4Hg15z9TV57Zxi8inivEIIQaOUbZQEvosttliGle3MMZC2YgcjgjAYw89NNtkknL1EYLY1uvwtttgibClOCTT99NNn+Jdww9QSmp2VRAOOobVVujmDIYbjZdmWcoU7GHPWAedRgScG/L3COukb5V999dXhrCdwIUBR5hDIbJ7isN3ppp020+i555orwNfW+IStDh06xBdffhl3FvTG7o2ErksuuSScC7XAAgtkIc5z75FuvvnmbKUkbKBNxlKdVk1N+TDgTz/5JC6++OJ49dVX460338znTKFRFBz66Zyqnuf3zIKJ9uoxNbzAgMG3QDnnwAQ9//zzs1mIoEATZbI60A1BRFhLyXL/Qlp8qBAwbr7l5qwtYaUoJ+kRRxwZFiXaxX/9619x0803xQUXXpA1WOqZ1PWIDFWfWh4ELBI0p4gfIufgQQsI5qrlfW19fBEGQE8wBc5BcfI6EzfmSX7jpp//ckwT2nnP3ffEwQcfHPfcc0/YGa2sCW9pUjGvzmuhmPn8i89j0YIBU059WrxbbrklDj7k4HBmS+221ep6fsEFF2QLg4WacEJwUEf75bta+pVwhsEiAEzYunX+3E6dOsWuu+4aBAeWm0WKe/QDg7rMsstmQU4Z6yJ4H3HEEaHMUYWm1llCmfEtmCxjo8GUUqy80krZ+mCNRXsGDxkcGCrvvbsQLrSvbKMkcHOOkvOUKBmXXnrpLATgCzKcl1kmCLGeE8r8xlhiesGeAIemEOpKOIOdc4q45vXq1SvzGnPOOWc4+wgNovQEe+VaUgLLLl26ZIsY/CLkwq8JJ5ggf6b1D2/mDCnrn+3b0QTKAtr9Dh06xJdffRW2aAdTZ1Sh38pS+LBefPjRR+EcKYKJMXBG1hprrBH9+/cPZfOLij+2e2d9m3XWWbOCuVXRB+dfEUookVjntLP44otnS4b1Af8p2S6ecoQwYcyL5uryf8MLDLQjNLAQz8T0G6G0cHhmwpE6LSpXXXVVNsMya5FmDbRyCy24YEBWSERLRaO14oorZKlWnXffeTc++fiTfBAZ6bNWY1aXWFF1qkVBgBYmpZS/CWH0A7PgWqWxD4HBg4cMazSlFDSKFbyHgeQnf8BP2tWdd9k5LLR/+9vfguaurGQB/2rgwJiu0K6i0zR2W2+1dT4sE4zBes0114w//vGPsdWWWwU3hUceeaSsHmgvTfif//znoKHlhkrTjvaj57UMwLBKLaOUuKYAABAASURBVPQH7XPXrl2j3ZTtCsvK4IC1DtE0BjSjfr/37rtByMKYWguBgvsEi063bt0y3Nu2aROTTzZZsLrvvtvu4WBPAl0U/1JKWcggtNH8nn766XlcHGAK/g4b9a6iaMP9Z3XkmkQYcC7Tffffn+GJKQUMvAX8xkiClTw8CQsbK0NZTr708SdD4xYIHeYB4SGllNskZJRuOsqOlVQnjYAd/GJhoeTdYvMtAm7rHsGUIAWOf/3rX7PrF1zGo3kuH30wDzDtYH7fffcFXm6KKaYI9KapgOGUU06Z3dXBNaUU2vjm22+LvIGayYmwnFIKFk/CwVaFNcgcSikFHB88eHC21mkD3ht77mOsdQRINGiithNlZXNusA7/NLzAYGBptEh2LA0QidtR586dY+WVV85uSiwLzNwQyiSFLCRVCIXKQgSJNPv5Z59lk1K/fq/HbLPNlk3fzLCkfBP9H//4R3B/qrSNdTgbWmKXCjmhTds2BWEbVDAFQ+KTTz/NwVsIWUv83Hr4ptZtWhdkYUi2VKIJFu4K3qM2MpjVpZZaKrtibLDBBkFLigEqa2N60M5WTU1hwSUk8Fl++KGHgusBxoi1wIK/1VZbBa0hbTj6rA0MBIECw+U5YYEGEk33XHuujZRK2PhmDBKN/w477BD8sS+59NL44MMPPYqUCmJS/CJAgLM1srjNtIVQt88++8Ta66wdlGIYOO0aK0wYH3xrn9iHVVddVbVsOaKoM6Y5o8H+UC7OMcccQdPs078qLDMpDYWxe8pLsGG5cS+Jl+QXT0Fprsgr4XzeuefFel27BqHM2JgPnitXlnHf0hL8EjcDxygIzH1455vNa/i2yiqr5HOvFl9s8SxMsBqIVUA7eIKwLIDLa31ey+sjiwTcpERAwz0jEMB7Vkw0Y6K2bWOKdu2yG5L36QcFB4Gje/fuMedcc2VLj/lEwSyPi1+/118PHiziLvbdd9/YdNNNs4XDO7RTzzSo4QUGEuZyyy0Xgl8gDs3T7bffHlyNaJu6FhOQVC+KnQ8h4eHqa64Jkmy/1/vFwEGD8mBjCpjPTX5INsUUU4SFCsLy52T6JklqkykLcozjVDVfQSAmaDVBzDP3PDkwkcsFn+FZZp0la1or8IwbCMw800zRpnWbvCiId7K40CCl9D0zMG7e3Pxb5TZx7nnnZd92PsAYemb88sto4Vq1agr0llvBySefHBgCGkWmfou7AH8L8+lnnBGDhwwJbgcYWkGJ0uFHHB78mM8555xsGabtpjXHYLBAlO9qlCsGRSo0CplOYLp69eqVBTIuFbPOMksWfjGvYEQzDk4YKDCicLN+WvcICtxwaVTBWMweusNVY6ZiXhA2jIX11Loqgb92GimBI9gstvjiUSoT4Dm8xit4jg+Zd955o7QugM+jjz6aLTZ86t0ri+nl8sKN5vHHHgsB7NybKDWVweR6B17EfUtK4HTbbbflAHG0oX/BjMM3MQgXXnhhdhd//IknQkwDZe8bb/4vC2iXXHxxoA9zFAIbd3NB/fD3vv/cl+Oj4Co4wc0hhfoHXTI+4E3wvfiSi4OQMcXkk4f4HjyetZXA0K5du+ACdn9hMaKI5rZnPt1y881BEHn+ueey5ZNlD90xT9A5c2LgoIFRvtv76y01vMBgoRHEMsMMMwTkWGmllWKttdaKTot0ykwVM5cgGAF4NC6sBiwFv11hhVhllVVj7bXXCuZxmhWTdsPf/S46d+6cBQ5MAnMj60JKKWgUCCDyUqqYh3qbDC2xPymlWHrppXPwJ0I6wwztY/vtto+2hXakJX5vPXyTeU+jhDnlL7vLH3eJDh06jGHXGqO6xbbbNtvknYsEG9JaU+iUX49GTzzRxNlNhq/wkksuGTSwWxTmf64wFtvtttsum/VZcg/v0SMwBe+//14Q3JRZY/U1ApOBEetRPOfSwD8Zc8YiUb6rEa6tWrUKWtcFF1gwa/zBkmUdEzRZwQwdd+yxIRhz0NeDhgUyz1CsldbJkoZwsUBjMKhgjnnCYNGE07pyZSLUNRVWIfEjffv2zTsC0cRi8oxPI8C69hsJtnBx9dVWG5bNMgZeBDCaZgzq2muvnRWSZSGbrIClIGh5Q4YMDrGT4M0nn9CMZyHobbvtttmX3njAbdY1dVpaIryKNyDA9u3XL2+TSkD6/PPPsjC2fKEQnmzSSfOGNjvttFOwQMBVdIYQhW/7/PPPM1gw9Pg/9WWAW+sJW2eXIkIaBQWlb/vp2+ed2Fo1tcq4PKRQTBBINttss6As1iYrBvrEgiDofJZZZ82KZjSGm9nsHWfPu4QJxCb4cI2aqO1EYQy9ux5TwwsMtshCJMvBMei2LFulMGExITHvERQsRIQL0uJZZ54ZWxYL1Byzzx777btfTD3VVLHTH3bKgSzKMMmefdbZoax6CKKFSVuCpiF4+b7qWkFgXEOAvySG6oxC43rkEUfmgLpx/c5Gbh9jZKGgbbJhwgq/XWG4Rb+RYfNz396qYGAxUqwE5xYWAAsrhrSsh/ns0qVLcB/FJMmXhzlCZzEA3I34K59z9tmBCfN86623Ca5OfhPm7GpHK05owNjSMlrYjZ02GyWV8OpcKLnAHiMKPtw7CAvWLwLCcssul7egxRituOKKwbpTMlU02xgpdcCVXzZXMsyZdRSDRvtqi1xl7FbjvTTjW2+9dQ6AbhR4l9854YQT5uBygc1lHkbSrl52maLttqtd165dy8f5SlDDlIKfjEkmmTR+//vfBwHB2NkowBhwdSFc01wTGNCj1t8FtqvXkhLBlTBk7kqsMHi3Pn36Bnhwg2Px8s139+6dY6NYAOBvSkMVt2JyBPvb3Q5emgOS+toT6+SehwlhD82wTStekQL5tNNOiycKS4Y29cH43HXnnaEe64V5Q7Aj1NlwQV+UM+dY3WyGs9dee+Xdyij2PK/H1PACQz0OStWnCgIVBCoIVBD4IQQssBhWDJJF+IclRj+Hqw2tbT1r9kb/q8ZeDTBnFQfzUhM7pq3bNQxzTKAY07ZaSv2UUt7W0/ae/OTHxndxR6IxN3Zjo716ayOlFCwxFGJikiQClLMtunXrls+48JtCwT0hjEKXFdLmB8pLZb7YHcmGC5JzRigv1NcOocFvyX3ZFuHYe0dskxCibe+WbMagDe8sk3z1vJdgTWFSb3Au+1MJDCUkhr9WdxUEKghUEKggUIcQYMW1Pz3L2djoHi26QGhayrHRXktsg+UdU0OLPTa+j3uHbVVrrUdjo93m3gYrAzcklrCx8S2sbrbSHltzZWz0aWy2kVLKu0DZlYula2wn7fJA2WabbYI1aGy3X7ZHCUKQINixeo5NGI3NtiqBYWxCs2qrgkAFgTqEQNWllgYBWu+UhroTjOm3cQ2QxrSdll6/gvn4GeEKzuMHzvX2lpTGDj0bl9/V8AIDHz/+bKU/LJOr+wEDBowR3JkUBccwd9uStXZrwBEb5q8oWMwhRE4SlOwQwk9uxLJjei8Q0w4Kgmx+qi2HhwjC+akyo/KM6Rks7RgFDqNSpyozdiEAv+yR7lBCp3+WuD5231K1VkKAqwx/Vbtf2NrQ3JdXPq+uvxwC4Cig0LaEApfRa63BaTtS2R0FvMFe8Cf6bueZ2++4PdAiZav0QwgIvLSNJ/qATtu9SCm/+WCDoUDonj17hsBl65o1y86AkgBmW5SrUyZ1jIGxsrWksbNleRnUW5Yb7WsLqWANFl8g4L78JDjKn96aKQ8PAd55F6siAwytpbV5Rfaw/9q0M49U/r77nrtz8POwQi30BxrQu3fvsPPQiJ9oDRRjYIcvzxzwZpcqB+fBXfgpNgFtwYfZyUsAurIOMbSFs/bB3tlaaA93L89rE5i/1qdPvPTyy3lnMe995tlnQ9yCOuZVLvPaazkI2/vxY2IszBN8Y2179fa74QUGE0uAnIlqcOxzfNrpp+X9c91DmnffezfvNe0e0kAUBBbRlCfJM7ldIQTC2L1791D/6WeeCcy/ye6537V1IQlCjLmAnJBXgtTK2cpLHQTYuyR1LIy1edrWB8+U+eLLL0NdfS3zHJ7jPfIgr3KShVdd/XVvSzcBm/qMWHl/+cz36ZuJKd+9Oq4YJXnqSAKOTAQLD/88C7h6Jqd3lv1y71u0oa0qjR0IGD879dgqUXCV7YAvu+yyvNf02HlD1cqIELDYCwK98647AwNmv23zbcRy1f3oQwAcwRMTiz5JaCRm1qnBgg3loV9ona2yPX/i8SeCImb039jya6C9GJoTTzwxwBBs0WKwRi/QekGdyliXBItjsgSDCtBET/iEg3kJLeuOjT5sb6usw07Rfvm2MjdHyrKNeLX2gR24uYKBcaDUwUCyeNlZR4C47UHhsDKEi0MOOSRsCVyunfIl660x4FcvENdaaj5ce821edcwZVpqgqPmvdOvKUVrvxOfY1tTsQJw2zNlxBcQzsDK2khJKvAYrwLmlLbaFQiNTzRmgpPxds59MAZgrD3JGBGe9/jTn+KmG2/MAkMer4MPDmNq0xvrAj7LGRD4MG0R/gRL33PvPZlG1bap3XpK40JgqKfvG6W+DPr668xAkQYHDRqYf6uIIFqcTj3l1Lj8isvDBKUxwQTbVxoxhUQ0JoQOCIQxgyS0Nbfedls8+9xz+VRABIBGRmS9uqRY7XmP9NXAgbHa6quH3Q0gpZ2ZbM/46GOP5TMi1LH7BEQn3BAw7MJywgknhPdBSARfnmfKQHj9EbSDWddX77IoKKsvJOY+ffuEevYXlmfCYDQRMBMGw3/SySfF4YcfHogYQcWE0a4JgOARpEwA9+Dit+3zSOZgQdgg3Xumz6R7k9eCAu5PPvVk6K936mOVxg4EwNOOMrYvtGODwCxwJ7SNnTdUrYwIAYsLTdWee+wZFiCMkrwRy1X3ow8BtBatdF6OHUpuu/XWAGtWYcGdmCaabkGIaBlh2XO7y9ifngVi9N/asmug3Wi1c4bsbmSXKb70GCU70Nhq0k5J1iVBoNNNN328/PIrsckmm4Q824bbgQr8S0hhnsCe/zeffMKH9cduPQM+/jhbKawxZflGu6IHrGCtJmg17EA866q1mT87uk2TzT0JM1nCCg4rN7Idj6yx1l118BvqGEdxDM4EMCYtEc4Y7DvuvCMefOihvOPWt4MHD/eZlLA0+ZNOOmmAiYf4JXEdToEGb3gJ31NK+VwXMVK2E6YAxbc5Xwvv9Xr//mGnI4IJKwTarj3JuNg633xyLxlHO13Zbcl8Mb76Y6zmnnvufA6MbYztnNl1va5xQyFo4N3UrcfU8AKDyfXYo4+GxUdQl0X+vXfey0LDIYcemvemhixXXH5FcOuAeBBnjTXWCAiD8cf8QkQ7bSCSzGII7FxzzhkzzThjPPLww/lAnMO6HxaCvBBYmgDMeokUbdu0ifPOPTcTYcFgBAZI9fJLL4X2nAWByJCUMe0YcTtMQE4aHsw77Y2FkVaT5Pyv668vBJZnwzaEd911VyD54XDpAAAQAElEQVQaNA6IiUAoi6z85597Ph+EBHERdnWVMaEw+5j6ZZZeJgS+2YbWou1wHguJBeH888/PB5UQpuw0YuHhHmBht1e6syssPCRr2xzap9jESillTYlF/Oabbh520F0Jk+o65hAYMmRItnKBubE3HnAQroxa61Wp0YUAjZb5I3BRmm666bKlz1iMbltV+eEhYAFvN8UU+fCqDh06xMBC2WPxt8h26tQpWFkt0oJz0St0mHAseBHjheYN32J1B3ZcIl55+eXApFJMgak1xhkYmBlbeYKh7Weff/65mGeeufNZLgQ0a8j6668fFFwlNMHfukORxsrTbsop8/708q2JlEcURWX5Rrs6B4CWeYUVVggMr+8v12eBsJhbwhgFD+GgpB3bbrttsCCg52WeupI8Xg2YXbReHpyfZ955CwHv5cAryGtpiWXg+uv/Ffvtu28Ipi+kguE+sUNBJ+Ag3gNtAG/M/YABAwLughl+jGcEt6WePXtGzyJ9NfCrIEirA7f7F8LC9AUtt10tngatef+DD4a9Sz6+zY5iMo0PgcTcMccolPXBOHBbogw2PyhvWfTMta++/DLwkOrXY2p4gQHy0KrstNNOWbtPcmw3Vbt8UIdTAw0kDT7BwsLjkJ811lwzM+GdO3cOVghMsol5XcGgQzoD7RARSAaJMA8k0Tf6vxG20rKHNeTBvCkrQUrItcmmm8QGG2wQGP82bdsUuD8kbLPlvkuXLoEZwXgTTiAYU6+9rE0aAgbhxTcNGDAgEOfNN9s8aIw6Ldop+Evqi3YIB/qtjsh8iythhPSrvj75ZhMGfLwPbOQrQyrXLkHGd349aFDem9v7ET7fO1HbtvlQO4u2HUhMFoKW3QZ8x8KLLJIn+LW9emWCRhOVUv0H/oBBc0qpKYVxj+/+leP73W11GcsQSCkN0xpqGrwtHn5XacwggCaVuAymqWgOzR1Y0B+MFVg3tfp+WUNXiyKBgULjLPruGzaN5MPtysISff4FF4SzWlJKwQoJVjPONFPG5ZRSECBYdjbeaONYdpllc744N5prSrCmpu/h3qdvn6AUcu4Q16QPC8aKkGD8CNHWnXJsRtKlFp9lbSaIDf72e204RSQlHV6CUgcPMaJQhZ+Ay/B8RCCVdTwzN8rnk00ySVZYjNhW+bw5X3lAXHPtNfHRhx9mZcH/3nwzKFYx5eV3UVaCdwmTlFLmVXhOYNgpiilZtYWX4W2x0UYbZY8HLnjgqQ3wLdvI16Kd4n/5mmzdMGYy8vPiB3w3jyhaCS4sDYsUfM+FxVw77e9/D25ULBh4M+8wtoT3ompd/v9+htdl98Z9pyDDlIX2Y6GFFgqWhEUXWzQmajtRtJpggjB555lnnsCYL7300mHAaVQsUBhiA0sTwN8NY01bYEJDlpRSMMEipu4hwoStWwdmm3TLj/P1/q8P+0CTed755oull1o6Cwi0DBO0miBrH/RRKgksguLdJgXCjpDLo7UgXDAPM6dps/8bb4S+vv/e++EUVX0p29Ke++sLQYcfnbqYe52SrxwBCXGXmPp9vzzfQGoGC5L264X0bTKQvJdYYomYaOKJs7AzZMjgLORoq1xQhhRa72++/TZbWwgJF114YZgsTHTeXaWxBwEwn2rKqYLlCD4+/8ILeVzg7dh7S9VSLQQmn2Ly+ObbbzLMwZ2Aj0lKKdUWq37/Aghg+tEciSYOI8CC01TAFl1Bs1NKGfZ9+/WLt95+O6YttIKecQFFu37Ba1t0FbAUA8J6Y82wllDwSF9+8UWO38Nc0Z5STq29ztrx9TdfZzrCZ3u++ecLYwBI1iQ4/9GHH2UmlQV63kLDrS35xsE7CHcpVfNhcLE+ggnYwWVrsrXSveRZ7b089/L9Vh5cay3GnkmeS98Uay3+I6WWB2/fOe0002bF41133RXvvftuvPzKy9mqznOBEAAGypVwg394JjyPPAk+ctslxIEpfgT/VcJNHmGCVwgXR14W00w9dRC2zZ9a+GvPOyX8HoFZ+9zN8UriJQgo6qBJ5pv3qKef3q3uqKTxXabhBQYMFcmxBPyQwUMyIzvjDDPEuuuum4PAuB7R4GOyCADXXnNNMGNByE033TSmnnqqbO574vHHs2sP7TnGG2IIaoEQfAl/t+GGIXjs6GOOjv8++t+YeKKJ82tTSmEhu+bqq4NGhilSIpkitGX/XCWmYW2LBSAhQzCH4PBV9z4TAfExMbgrHXHEEXnnAIJPSil/X0opILH2yrIkXciPsYS4EiFKOe8Su8HSQHCiDeEGJWbBROOe1K5du7xQs8h88/XXgRjOOedcWVtFUtdPH9yqVasAE+SLlcYYsK6AQVT/xioEwJYAByfFwRDOWJcIyWP1RVVjwyAwe8fZY6EFF4pTTjklwHyWWWeJShgeBp4x+sEaOnWxUIMrKy1XGPQwCmLy1ptvZcZ14YUWDvFYhxx8cCy/3HIxz9xzZ6UJwY0iZow60AIro8sYGy4yfzn55LDmUDrNv8D8IZ6NYii7mH71VbAoWE/kWx9oc+edZ968lgANpRJlmLWAVVyAtHlg7QR766dxsD5ae9Rp5NS2TZts/QKDJZdaMq+flHHuJYyk9dfvMlk/5aWUslB26aWXhPW4fK5OCVtMKHjTfKtTlmkpV3wEF+4DDzowxNfwXuD5gME/++yzAj/jW8GEyxY8tCa6CuKHm5Su+BBWBeuiuFU7GrnHl8DzAQMGBDrDkob2XNvr2uw+3nrC1uFkaC583pNSCsohyXsI1IQDnip4KO7dlNHcyvFuZ555ZlYQzznnnNmrhSCOl9JWPaameuzU+OyTBQgBJCl6L+aXDyfLAgQU4LJhwejbmYB2C/JguDbffPNsvmVe2m677cMJfqutvlrePsshHxBLYDANixMDXe14wJdui823iEMPOTQvbt6JQIuhgED8E/fYY4+M/LQ2XHhE8yvjnTvuuGNAKAHIgsy0R2jxTn3UN332/pRSrFcIPU5BRLi5QHGJoiVCdLyT+xMXKcGZ6kJg3yJfO6wWJGQBOwcfcnDs+ec9Y8LWE4Z8E8ophtrh3iSWgUDBvYtpe7ZZZwunF4In4WufffbxucFas/dee2WrAka24+wdQ39N6lygxfz59T8kpRSsTcaAb+sxxx4T6663bhj/X793LbMHFiZzCO7bBWW/ffcLC1HL/Nrx+1WEBeZ9vt3caLgToNkdZusQt9x6S7YK77zzzoFO7rPvPqEs2okpoLRBZ8Zvj+v/bazi4ARfN/jd78Kagr6v33X9EMOG+eJnTRCwPoGvdTOlFMbAGlV+JWVS165dw1pjjbKGWju0SUNLG861l/CAoSrrNep1xx3/EJtvsUX+fF4OxgLMc0bxh9XfGlsq01JKea2Ux5oGt9dbr2sIbC6KZ8ENv+IgQuspLTYFIsWf8sq0tISZf/qpp4PCE9/y+Wef5zgA+MYK2bt378C44+kIGBh4DP3aa6+drWRcpeFi3759Q2wnvguPAl7c6AjTYjYJyQQLzP0Sv1ki0BN0BZyV8R47gqH/BGbxrto1Byhr4TzlLCuI+NO2bduGeUQQMUZnnXVWVjibb/U6Rg0vMEAKRK6UyFu3bp2JncH0rFOnTpnBFUxj8GlGOi26aNDAQEh5pHcM8+KLLZ4ZaSeHmsgIABcdCxqJVp72ROQTUFIq1GIFZmhDGdKxBU3SHiIB8bxTGQILJIWg2oXokFBfJe8jmEBo36N/BBpt+a0Nk0FKKYV3WoBNHu+mie7YsWM273mXd6ijnO9dtNOiMcnEk0TbNm2jQ4cO4Vu03a5du6wlEexc9mmOOebIAsGUxTN9BBPtFJ+bYyvcm6CEqQXmXyCU8axKYx8ChAPjDzfAuk3rNmP/JVWLw0HAnDKfJPNjuIfVzS+GQEopb76AhqJt6J5E6WH7alZf8MYgWdTRXe6UghkpStDFX/zyFloxpZQFWri69FJLhbUJ3ReftvhvfpMtxJQO1gj0HtytGymlzKiCdwkaDJE1BGPmt7XM2lGuYSzg1intlXUa+Wo9n27aaTMIrK2ENrj64Ucf5TzMZzkeOaP4A67qoet4AWsxelM8ipRSGBs8SUopeEZwIza2xlSZlpQocH0jt2oxM1yFWAd4hbz00svB1U6+JL6SsOA3AeCll14KwgbrgHvbMBPWWNT69OkT2uS6RIizuY109913Z6sFtyS7KqmH2ScsaFciKBAc1BfjiiZxZWLpYQlST18IzlzL9ZGiVvmlllwqx2DU6xg1vMAwugNDY7jqKquMbrXxXj6lFALUxFWM7ZcTJFg0EK4xaZsAQUNFG0s4G5O2qroVBCoINB4EMAy+mpbu4IMOyrsnua9NlEAsEbSDtfnV75+HwJ/33DMrx8qSJbzL+9G9GgNjUQluI4ec9draOlGhfR55idHLJajxUKCgG72azaM0IYhgy02IizS3H27SI/52z0pWlnOvLDdrV/eSMvJsJuNe4i1h9zDB0Op7JnkmqVO+070ykt+eaa9M3qVsma8d97xRbDrjN/fyeoV+wwsMXGKYnfhWGiRBMvaYZspzP2Ii2Y+JewGCS4J1dsE///nPvNWpmAHv4W9XBqW6l0jAdh0iNZOOSavaILHS0CvzY4lWmYZixOfex/eU5oFELih6xDI/dU+jR+tBw/FT5X7uGYGD1ptG5OfKVs/HDAI0GXDOeNezyXPMvrJ+aqMrNE3m7Gefflo/HWumPREcyL2g7D4aSHuHBqJnNIPcXWhcyzLllWWXVVVZ9VgcaAVLml+Wq67fQwAsrRFoM/ciwczcOlytX8YCDK2d1pGyJviiNbaptAVr6UNPiyumjmVhTNbP8j3N/YoGP//88+FcBVew8U1gac0HN3F/tjgXmwj/Pccj0HrzgceryKtNxgOdp8n2DkmgrfZqy7XE376T1WDEbwVbMGZ1YBmAo76/b5++IQ+eg5M8Ce8nr4Qv2NsQQBnvMA+MiXaVHzGhL6wennsXywLLmj6UZZWRh7ezVqBh5o13lGXq8drwAoMJJsjFRDRAGPETTjg+m/Lcj+3kPeIFSJIQxs5CpE1II8rffe3BIwgDS4EgPnXEIzz3/HPBfMaM9Uv6B5m9E2FiQrOQ/pJ2xm2dqvWxBQHjy0e5Z8+escsuu4TFfGy1XbXzQwhYaMxNWqUTTjghBNZZEH5YssoZFQhYsClX+AKX5dFtsLW4o4385dE0sToW9bKcK9pKOyiOK6WUd/255JJLguuH51UaHgKYI5ZfQaHlEworgc8YoDLWzsF4YI/5KctZP8W+0cqyxl93Xa/swuHg0Npg3rJ8I16/Hfxt3HjTjSEWBB7a4AQTitG97rrrgpDAH1+cgrgRsYnXXX9dhqM6cFmQ75lnnRW1DGbv3r2jW7duUc4Vbi/oDu01RrklwxoO4p1o9sGx/Fa/77n3nhzL1LNnzxzbRGlG4N1hxx1C3OW+++2X4x/UAU9CHJ4LA4/pt17izSgY4LzNAfBwDt5TBOwl3wAAEABJREFUpzYR+C66+KJQDuzNpR49euSDcY1N72KMKGjxnNYIz8wnNM44eVdte/X2u+EFBghiQYFYBsfOPl98+UW4v/+BB4K0DqkgmDyBLyY05MPMq0/rYsIbcD5uGAa7RfBN+8c//5FPItW2hHCKmHe1Hatdk2hfSMYQMi92Q4YompM8/riIhB2P+ItCqs+/+CLvkKBPJoA+8qeDpPpEwyDPdngItXIYRwTeNzlwBPHvtGinfKDO4088kb/VziO0dRAfXJjJLr3s0rBg0CzlTlV/mg0E4ILALPEwCJRFnHkV0Wo2H9HMOmou202GSdo+2+aWOdrMPmPsdvcXtoaWolmUJQM+/ji3YhFHwwQx8i/225afGFr0mVUnFyz+WIjhvTb8LrJyDMSCCy0U6LX5Ia9KQyFg/bEJCBoB9nL5WmN0uErIY33AMIGrssZAOcmOMSw6hGSuMG+++VaIqeMWZt1UptHTwK8GxmOPPhY2MYGX3JDA13qLCWV1f/Kpp0KMIB5BgP8D9z8QLJZRCLwEgl123iWuvuqqvGV5CU++8WuutVY+P0DMwlVXXx1cktq1axcOLGypuA4/4SFeBZ9TwsMVH4OfETcjqJhnBOafYLbwIgsHPm6J3/wmC2lwmwfH2eecHc5zAGuCiHgEsTviGih5//q3v8VOO+0Uxg6/5T1lwstdcP4FeVzwVywR5hQBWvC/9cBYEOAolE455ZQc02nOCLi+8KIL83b8ZXv1dm14gcGApDQ0+NhviV9cU2qKHt27552QIAqNiyuNgEGmSaEZsDjdcOONccaZZ+YAGlouTDphYb9Ccn3i8Sdy5Lt2Mf+QF+Hlv689GjI+/My+EFS52pTS0MAlFgXIjWlfYL758y43E0w4YbaEkFJf6/NaJhRHHXVkMAUfeeQRWVBh8uInZ6vTPfbYIwfU0M69+eabeYeA63pdl7dkO/mkk7JmgnABkQlI6l166aXxwvMvBK0RM11t36rf9Q8BBJRViw+rQESBi1zJCK313/vm2cOPPvwwbxtsoRaM2KFDh0wDLCDN84t+vV6jxRQm9jCfasopc0cIu8z7FlgZ/OEHff113jo6pRRcOeRL6mPI1K91zxTciw5S7ChXpaEQ4NJlRzsB4ikNXRcxN5hZW0xifsDMuvDHXf8YhLRSENMCYRn8MUaPPf5YYH4xQ5hfiq7asso3YuLSS5iyYyHhy7pqUxVWBfwAWG2y8cZBYw7u8uEuWJ5x+ul5W3QKiNk6zJZ3RSphaBfCPf70p8D0GoO55pwzb5GL5j9eKAS1XZYd02s91Tf/ba8MXn5b88r+wee55pwr75p0egE7dIOiwZq4yMKLZFiKf4KXhIPTzzg9llxiybyz4IQTTBBv9O8fX371VYjbpITFp80y88xhjKyhb7/zTvmqwDvB+xVXXDGXR+/NHZsACEK3C+U7774br7z8chBkKI0JMZ5T6Hn+wfsfZH5sWKN19qPhBQaDakxSGkocnbyYUwzV8nMBspOPAcd0p5TC1qGYbxMRI8+qMPjbb7OkWJYjedohgukJQnoHJCHFmvx+EypYGEifhAeHDylXm1JK+YwHCC7R1PR7/fWgZYPQzOqElynbTRk0Pe5JxG+99Xboy5RTtgtt89Ub9PWgIMQIOiOweI9+6pOJJX/HHXcMCMxtSTt777132ErPNmMEHnWq1HwgMKTAY1YzwmhKQ3EcE1XiffP5kubT0+/Pbo0C7CkL97WLWFT/RhkCGAC77Mw191zD6qCDtIoWcXFQnl980UXBCoEBQyPLwn7bUalDhw5lVr5OWQgfNlpAG3NG9SdDAHPfpUuXaD9D+xhcWLrRiTffeitSU1Pe9a5du3Z5PaDkwqRZuwgJuXLxx7pmLbHlN402LSxmzHrDBRaTVRRr6P/or9gQgi8XupRS2JqWxwLeAG6CM9hzVyEcdO3aNW/DDt9ZGFjSdt9t9ywQlMAUp4Pp5ZZjHCkmUxq6A9ann3ySmdSybEu6goltS+3sCGa13wYfnWcFrph9Mai2QJVvHJSlQHMlBD/80MNBMHZgodgDB98WmtXM26Hh6Il66nAt0466eCiKZPjNmoE+4cvMATQspZR3ksS38Q5RjmDBcuG9+qj/2ieQa7MeU8MLDLT0JG9uRQYIcaNFaV1o79u0bRtTTz1NkP7aFr8hB2JoMpuQtuz79LPPsk8sJtsC5tAQCxQkMYEtSpBL235DWlYJiOT8BFaK1m3a5IOFCu5CseESJIWAXEmYge0zzHwJQSEuxCMoMPuaNOus838xaNCg0McOHTqELfDKPZmVp/HM31O804vkufoehIoWWj8tFpBbfplSSopWqRlBgKWsbduJYmChJYFzBMQvv/pyOM1UM/qcZtHVNm1ax7dDvi0YrsFZsMcYWAhSqubPLxnAlFKgg0MK4Vd9MV7u0S50Fs3l3kErTnuIgVCuNmEkpDIvpZS1i7V55bPqGhneJRy+/eabwDSllIZZcWhYV11l1SJ7SBAEyrJtJ5ooM1zWohVXWDH69u0b5Vpl7SzLNfqVBeAPf/hDtkR27949bFCC94DTYPNBYaXkR08wOPzwwzNM4SqhWNCzmDTMprJlouF2JpJynmOOPdOm5HdLTta3Eb8P7nETcuYCfosQJbYjNaVs9VWeFQcfxdIDTqxm4P7vG/4dX3z5ZcGWpZzwWWIS8IqUFpNOMmmUW+LiGT/48IPCGvFlXH7F5YFH40KGD0P/KVsJKu2mmCK4ic05x5yBT3Qegz4SMPRFwne51mNqeIFh5plmypP2pJNPCr76zFomb0aO996Lc845O5tdma9ZFCAXP0NSIZ9BpsPFFl00SKPtCu0LX3+DD/FGHPiUUghkeuDBB+KAAw8I9VkYaLkw8hB+xDqQhtWA6YrmwF7ADm5r1dRUIOdX2eRLkLGAMrdxR1p66aVzMJS2Pvzwo+BH53yEj4rfzHL891586aW8/CqDwHi3NrxPe9NNM00w24MHX2y+qaXgo0yVmgcEjNmCCywQrGP8L0/+y19inrnnyX7czeMLml8vHSI2cduJ46ILL8pughajjh07/vIPqWpmhvXbb77NkJhm6qlz3BXXC4u32K7X+vQJFtH33n8/+G+zqGKscoXiD9omFT/zf2NiIUfrc0b1ZzgIgJU1IaUUGE/3GBsabC6rl19xRQj+tE6yHliXuF+stuqqQSN+9dVXBxdaaxEBDjNLuPN7uBc14A0eAuP/wIMPRvsZZgjB5ZSIXO/Al1LnwgsuCHEk880/f/avx4DCaR4L00w7bT6IDMw/LAQL5WiljzjyyMyotiusZ5hecZXW9gEDBmQFUSMIbL4XSrE0sn6BNSXtbbffns8TAUNnPq3w2xXyOQu8PHpdd13gjw4/4vC4qLBU8ijhHbLR7zaK2WadVXM5rmC++ebLCqCzzzo7l1OGchU/5X3HH3d8nHH6GTmYnXsRRa13EUSMlf507tw5KHHffOvN0Jfzzz8/8H6UzZ9+8ukw5XN+aR3+aXiBgWmQln/mmWaOZ595Nh/Sxg2HVn2ySSfNJj/aALsT8DOEkCYeqZXGnx8t0yz/QsF3kAGikB5XWmmlHww5rcCpp54a7advnwkrM9SxxxwT8hdacMHgFkTYKCvOPffcwVyJsaeBYGnYaaedgl8upHRYmsNeCAX65ZkFU38JD/3f6B+bbbZZPh0SobfIYiIJLr6va9euMe+88wYJ3MRqU1getDvrbLPFyquskp+ZdKwlKaWyW9W1mUAgpZTHnvaV1oQQuO2222btajP5hGbXTRokbnwsl5jSvffZOx+G2Ow+pI463LHj7Jk26hImlUVV7Bhr6SabbBIDPvooK21OPOGErK1NKUVToUWM7/45SBKNc4uGmwtoJ4uEvCp9D4GUUiy79DJB+ykXM2NtscZggCiRuFBg/u1UZQ0rqmQllZOJrTeUVyw/dmUjaIiJwyxZV7XZyAn+cXvZuVjHvy2sNxh6a/sSSy6RLTu2C4aXrAXcjsUtEiIwln/cZZeM3+gK+pJSilatmrKlh+LS+l/cZI8FWm3tEuC8r6XCHizEF6AFvpM7NcsWXkeCd+KfMOfwF6/Ga4PQQNiiUEMf3n7r7TAWrMHqwFtjJc/GIZQM6PqLL72Ylcz4Pu545oJ3UhoT+CabdLLMRxLmmpqaglVDLKkxxRu2bds2fve734Xg676FBc5v76CI9k4CeNTpv6Y67dd465YBxawL6mUaJDzQBkKUqQot+9bbbJO35DLQNCQmLbegQw89NDPiKaXsW4hp14at/wz40oWWnzAx4oe0atUqnObnPd6H+CqrbWbe3xfMnD6V9QgMytgFwFZdDnXhj+ewkv9bZ52sORCkpoz3a0NbiLV7SVkEHzHXjrI77rBDdrXaaKONguSsDQsDZFYXDCyqJOevC6LmGUao7Fd1bT4QMKbGl5kaftopovn0vnn21MJ1wAEHZNqxxG+WyCbt5vkl9dFr9IigqzfoG+Yfk0Czin4L+ESTKWrQOrS3S5fvFTboaNeuXVXPbjWYX25MmIOcWf0ZBoGUUiyz7LKxxuqr5zwCGiWSXY4woRRYBx14YNju07kK1qONN94kCGAUTtZHzzC87QqruzHC1Bmz3GCD/yFo2fnIWmzDEldrbrsp2mVGkiuLtZorkhgHz9Fveccce2x0P+ywkEd5yI14/fU3yEG62sQj4Cs8F2tJ2cmXXpyPedPSQM/yBb9YtAhaGG9CAMsB7b8rSwv3cQpfQpNtU8WeppSCkjQKPShtv3oSyyQlqXKUwHhBAco2vKEoxguJD1XO6cyEBGeSqCuxFhEe7FpJCOC+pA7ekaeGMv369QsbkbBw8iA555xzwu5M+sObpV7HqeEFhnJgUko5KCViaA7EOrBY8BdZeOFIqcCoodlh0TIRMf7fZeVLSsPXz5k/8Sel0Sv/E03lR/qT0vf9lCmvVVMrP4clwog0LOMnfgiA3nDDDYe5JkHunyhePapzCGCk6ryLLap7rQrlgNSiPqpOPoaSY++99sqaPl0C51Gla8rS6mHA1K3ST0MAvDD7lEtlSXkpDb/elM9SSoXW+/t1hxUfcyumLqp/PwoB+Gu9pZz0+0cLjsYDjDJBgnZ7NKo1m6LgxFrAslIm3hWSe9c//OEP2U3IzlTy3OfrTn8IeTvvtHPeJlVZyTPJb8+5gnO/E+ivrqtnfrtKZfny94j3tXU8U1ceC5zf4lXssMlVjQWkXgegEhh+ZGQQRIhIgq8tQqPCglCb90t/k1x/ad3xUY8UXS4UXABMzvHx3uod4wYC9Y5v4+Srq0abJQTgqvRjnU8pBZ/vH2NCf6puu0LrzXWUUkj7ykp+V2koBEaEB1gRsLh9eEazO7TkT/9NKeUgTwJepbD4aVh5yvogVhKc3Y8sgb0xGNmzEfNosbnhtGTYs6DjVQim5XVkvz2TPJP8LpP72lTm4/9YJnhucL1Tpnzmt+TetTaVea61acQyaGZPznAAABAASURBVJHnvDd4mvjNMjLiONbLfSUwFCMhuItZi69fcTta//kIMjlp46cqMlvZT1k5k53vmjMZmND4wQneK+uLuJfH/FvmjclVZL/Aau8esR2xEYJy+OeN+Ky6bxkQMO7GmHmWm1ktrrWML6y/rzDnmMIl9KH+elifPUIbwY5bhn37me7l1fYWfbTTCdorH21Fv9EyZcH77rvvzoGhfitTJnOByd/mFPySuR7wERfvNbbobfmu5ngFH2uPDRLQChtg1H4H+BoT7mD8rbmBOIjKlqDcV8v63DVstOBewLO11fjUtvVLfrf0OuDFH956TTDwvebDG/97I8c3gLlxESMCx80RLjDwX13lGz2Zx+CBt6qFhTgQPJcEX+EuWqIMWHM34sLlXoK/aIVYETCH0/g2z0ZM2nnm2WfzjmCeiV+wCYN5xCVM++J4vNt8Qb+Mq3dYm80r9eo9VQJDMUIWFSYnAS0WkCJr2H8D/VODaaHh2wapykrqlL/LK2Q8+uij817IkJCfYblg/ee++wLCKetdCIYDQCBdmSff7zK5H9l7ap/7rdwjjzwS+lgusPIkzxEgz8HA/Y+lsnzt85Hl1T6vftcHBBCkE086MXr37h0C3zFL1diNu7FBQ+yVbmcMhzg6EXfExWvcvb15t4yOnn322Zle8Svmw127SKN5hAkBgxhQNNJe9XZ/U1fiCwzughztjV4rIKPDRx11VBCemf979uyZT2U1Vp41b+iNee8JAtYp/tvWRDv5gXnZMqYLrDC0Akr32GOP4KetvG0j0ZrjTzg+rv/X9fmwT4wW3Lf7DEGjbKe6jhwCmF27JolxxFCi0xhM40B4w9Dygb/wwgvj73/7W975B66LTwPrkbfaOLngJ+7AQY34qNovp1jo1atX2NXIOgh3S74H3uP/xDaoIwbB7pDoCaYfDdeumNAR8ZjCwXO0Cu03R3oWdAXOo2HojPbQrF7F+60Nu+62Wzz9zDN5a1fjbay9t97TWBYY6v1zf9g/E5L2AzMtCVRRCpEkUQoicvgMxBLgQkCAlCRFkxeC2cKMVubNN9/MW83xRVNOG9qS1IFMEAOyMhVutdVWOfB4skknzT6f2vQ+7WlLf+68664499xzQz5tpbYgn21Wu3fvnrcSpMFBUGzLhagoRwPh2yRCASS2p7DANdt7WTQF/nEzsg2bxZdQoS3CizZsUUh7YUHWZ/3wzLfQbBB89KdK9QsBWifalDat24Tt4vjIwnFErn573bx7hmkSyGYBksxFC1Lz/qrx03vMPbpncwebM9DOYZjKt6NjBAZuFkz3tqXGQKGtaJ3njz/2ePAD50+MTmmjrE/4sCOKnfDsciJYkhtI+/btAyOsjbJsI17RfX7vgsjBx9qH5pewwIRhmLgYWa8EPAseF+9mu28M0hSTTxEHHnBg2H1PsCiXDsHQhIqyneo6cgjAP+s1JtU67d58+Pyzz8Nvc8G2qgMHDYrFl1giML3mCZdh6zR6P/KWGyMXnT3llFOCMIunqf3q6aafPggSNqhBOwSaw01KBwIYPtC5WuBMOBAk3qFDh8Do25WSUKY9fKEyfhsrApv04QcfZCsQHs+uSGJ+vMsW9miQnQrFKiy40IKxwALzh92ZzJFPPv0knn/hec3VfWp4gQHzSzLn0+pUZ+crkCotNE5FFtkOYUiFmPT77r8/n7yM8YZgCCYCS4uy4x/+kBEVgbVLASQpMQDycfsRNI3gIrB84uweATn1wQ42JjxhwWmADk+z5SpCCwkRccKCbVkx+3a72WvvvQJDePHFF8eDDz2Yt1NDpPUnpe+D0vgwfvXll2HnFsjct2/frAEidT9QfBOBhyRMCNInwtHbb74VV151ZZCWES1SNGYTQySPsFF+X3WtTwjAJ7hjW1z+kRZ6O8NgrH62x1WBXwQB88fcsLuMOWqzAPAuF5lf1GiDVAIzu8PY4xxNhLt2SCo/3+KOBtqRB4wxtfamB2dl+H57hj6hl4I97TzimbTWWmvl3X3QbS4dGAL++baixox5n3KNmkomSwwfOsG1A1NUwoNV3BhReFn/uFTYXhwjZFysbdY1ZcDUWkpxxgccE2wdKduqrj+EABqBTgsSJwhzayFswXXP4Oh8886bt8WWR9hF2+0KxkJGcP5hq42TAy9t9dulS5fMvNd++QStWoWYBHDC91EogCGLe1OrVrHh734X8BUM0R6b24A5JQY6oa7d7/BOFLPaNk/AnkJXLIU8+C/W9fjjjw+0acp27XIcD5rjvffec28448EcMX4OcXvm6WfyGQzq13NqeIEBw2zhYGLlg2l7rIcffii46XTu3DlL8CwGpFED2aqpadiuSZBFoIrgO4j10osv5i1K2xfaKsIBq4Q6EoYdM+6ZRY3mHtKllLJ1gX8bRGM1IEw4QfCbr78OSCWanmTsfZD1iccfj6mnnjofvjXN1NPk/ccFShFs9J/0TOMQI/yzGFg8EXiaz08+/TR8v3YVbTXBBGEC+Z1SitSU8t7a2++wQ+jX5pttlg+RIawI0kGolK1S/UIgpRQFwoZ/cDSlYkwHf/sDYup5lcYOBFJKBcjTsMbAneA2LKP68ZMQsEBTTFiE0Sn0tayAhg4q6KJgQXm02hZiTKl7yhqKGhtW2ArUPdruWZk8t5hjcLkYoJeYtJRSWAPKci3tOirfg0ka8PGA4JZESQauTa2+3/HoqSefzGsPYQKjxG2DognjwzUJ05TSUNxPKeWDruC/tYKwYL0ZlX40chkwp9GmXLRVMGUeoQFuEmjnn3/+aCpgm9JQOGdYDRkSqYY3yXkN+Mc8pqCBcyP7fAJB7969g0CBbhBwr7j88ujYsUN8VvBDH7z/flDY4s3wYyNrY/CQwcOy8XUdO3YM+O+dKaWstKXYWG655YKgTEhAczwnNJsjiy++eF4jKJLNDTRKuWEN1+mPpjrt13jrFgab9o8EaeBoRW677fZM6MpOIHL8MzHTEInGxeSFACa3PMy4wcfg23OXIAEhyzbUkc+1Z9NNN80nBXJbUiellJEHU/H1N19n06O2JcIFBNOO9xcFo6nVUEkZQtPE6Xvnzp1DEA8zpj2X9UOd2qQ91pDynbm97woQGlJKOcbCpEKYPEopDdu60F7QTH3M+L5P35SpUv1CIKUUk046SfaVhF8I19eDvs4HEtZvr5t3zyaaeOIwj815tAGtoMVOKTXvDxsPvUdH7VXOQmDLQe4uaFP5akxRQSDL2+LnkOGEXwv1hx99FA5zo/XmekdLbhzQ6g8+/DBOOPHEMA/46FvshzVW/EipscfIWrPWmmsFS4y1cI4558ja7AI0+T/4W0fA0gFWLDsLLLBAwXB1DFbtaaadJtMa4/jyK6/ktQOzq3JKqVi+kp9V+gkIgG2B2GE7VPjJY0CeQFmKOuv+4EJAAGOJcvI/99+fD3RDZ36i6YZ4BD+l8mPByPx3D0cJBDxK8EH4nEknnyy4MrGWsT44hTmlVAzBkKzMxScpp02M/QztZ9BU5pXyj+KPZ8Ul4zdFBDpk/LhW4pO0b/2l1HVWDMFGeUndlEZ7Xqg63lPTeH9jnb3QgRkONnPIzPbbbx8WKdp/k5L51R683bt3j9f7vx6L/2bx7J6D6VcGErIYcPHhhoBw0oxxEeK3DCHLz1UWwhAi1llnnXzQigUNA06jNv8C8+fgu4MOOij45dKkQSTCDIRXF2FoPeGEWWqF3PykS4mVJKsvtP++B5LXvpt2B9HRnrb0h/ZNGe8hSMw+e8esWTrl1FODxUP+l198GQO/+kqx6Dj77GEREefgW2sX8lyg+lN3EDBGnRbpFAihwFBMEu0G/K67zraQDs1eaJxY/pijxQqZRyOz+LWQzx2rn4EeHnHEEcFXnqsmukwRUr5k1llmiVYTtIoPPvygzMrKHfQNnC3EE7VtG+eed152PcIAc1MQf4U23nTjjXHxRRdl11GW47/97W+BJqJp6mOAhzXcgD9YxcXlPVRY2bnlbrrxpiHGrgQFRksZ68f/3vhfsFajKaz01h2n5z719FPRo0ePuOjCC8MhbqwRxhUzy8W3bKu6/hACcBAuf1msubTWPAuUwoRiNlnUWhUKQ94Hl15ySfA+wLfcesstsftuuw0n3KnXiKmEIT5HuuuuO7OCFp/FnRp8WSHABj6ffNLJsd+++2XvEPC1XqIblMRwlkVHADM+0E6X8Pyuu+4KG9NoQ/IedMSVUKce+o+Xe+vtt2Le+ebN/B3lBXclY6geq4LnBMNSsJZfr6nhBYauXbvGlltuGRAEYSP9CYhznLfFHpO+xpprxOabbV5MyN1DnINFhamQ2Zt234TFEAg6kgdZxD/UntfgpFHtQgqEYP/99w8BqH5369YtllxiyYyAk006WWbKEeL27dtnLcPcc88dFkLBTbN16BC77b57LL3MMtn0RcCwPzZE9b6VVlopBPWVCJdSCgwiwo1J5LdnsnBNclonQYHPnn716N4jWCfmnWee8H0WWoHZK6y4Ym7OIiFIiHCijZxZ/Rk5BOokN6WU96uHeyxHW2+zdcC3kmDVSTdbVDdY9/jPm2PtZ2gfh3U/LMzlFvWR4+hjaOMcZCRAEB2zuKJR5evaTdkuCGMvv/RytiyklAJ9dBAbuos2o9tcOiln0GRtdCjoJmbV4o8J4y6AZqOZFCmECXlTTz11+aqGvPLRRh+++fqb2GvvvWOrrbeKWuXTUksvFRipfv36hSBQ7rOYHusVRkr93XfbPVsWuDVZRzFo4h24O7UthLmGBOwofrR1GMy4GIO7OWDXMC7RrD7cwCgiBdRyWeK1AO6UQdyYRvE1LbYYb5CUUqy33nrZ4uK+Xbt20b799HknSnQYbcHrUfJaE8FZYs0EV8BBJwjBeCPjAe74H7QFD4RO4YG0IaEjNhWxrqJD6D9aREjBC3bs0DFbJJRBj9SRCNLPPvNsttBxb/Luek4NLzBAEgNYDpLFiesNpOjcuXPWlGyz9TYB6TDtdiWADBtvvHFgCCAO0xPNO2SEHAKLMemQML77B6EgcYkUmHHIAzH502mfsHHIIYeEd0BSeausskqoq1/eOfVUU0X76aePnf7whxAcCJEhpWBtix4LyXevzJeUUggC5EJkAV1jjTWyDyrhwSLLItK/f//8feBAACnf73vBQDQ/gURgtWBvgo7vzi+o/tQ9BOAhofKwww6Lbtt0Cz7bdd/pZt5BtAGdoLmaY/Y5mvnXjL/uE7ZoTcEOHWWFFahf9mDSSSYNOyAx8Vvs5aOPyxQKFMxWSikEOhMKKD3sQmIBVwd9Q5cxtxQ2GF401cLNRalkFrQ5YmqUe4wUCzht6vpdu/7gs+HyggstFCzo6Eq3bt3yGomhxchKBAO0xho2ZMiQbC0yVsbgBw1WGcNBAPy4GVuzU0rZYkCQJRQQGPANeAjruU1S4LA4HxZ/4zFcYw14I+6G5p/Xhx2+xNfceONN8d//PhqUB3gYruDK8B72sPrRAAAQAElEQVSpTQLK7cAmj4cFIXfXXXcNXijcSil3eZZ4bqckNMhv6YILLgi7Rp5yyinhntt2KTz0vqt3zvN+ZbhbKiOhcfgv7zJH6n3IGl5gqPcBGpX+ISAIBgsEzcSo1CnLEFgQHBq4Mm9k15RSKGshtzin1Dx87kb2LVVeBYEKAs0TApgiVmDMJ+ZqbHwF5QfFEUFjbLTXktugbNhs002jVoj7ue9lteHLjdn9ubLV8woCYwIBeMaNkScFvobykwLCvd/ydtppp1DGfW1SRpJHcYvBp7Cg2GX1tEVq+VybO+20U1buKq9d1rayXYKG8vIocZXxzL2y7iWWfxsH2BWLYmNMvn181K0EhvEB5XH8DlohiygtsgV1dF5Hc0GDQTv3U/W0S6vRubC6tK3Myj8FqupZBYEKAuMQAjR9nTp1ym4vY+M1GFquNGNLABkbfarXNlJK2dWDGxgN6s/1M6UULO+UTRRbP1e+el5BYEwgYOtTVsoxTbwr7M7G2jOmbf1UfZ4phG/eH3isMfn28VG34QUG/pXMRD9mDhJV70CfRx97LPvM/tygCFDWFr9Opi/t/1ydX/N5SqNuKUhp1MuO0TdVlccqBPho2xni1ltvDcHPfDHH6guqxn4AATSAWdw+6oLhuGb8oFCV8bMQADfuAH379s1bPI9YAV7bZIJbJrM+HBcgyoVyxLJosy0quSChz9wP1B+xXCPe29HLjoFcTgWAoxngIEjU5hrWMXvT22TDzlOeoyPcMmxTCebGSp0ymQMOd5PEAnpurMQ/lGUa9Qp2b/zvfyEIVoA/X3vwASd0w5V/u+eSQHMwdzUmeBZudPJKGKpvHEp3Gfje//X+Yfy8ryzXUq/mtM1gxB3UfqNvRxvABfzADGzA3UGD8NG9OmAK3uCrrDw7JMFbc8A4oel4O3PG8zKV8BcQrU3vkYfGeLe5oi/ytW1TB+2iXWicTQY8L9urx2vDCwwGky+ZBclgDRo4MAfHWHAkfnB82D795JMw+BAG4pSDKc9uQ2UePzh7fEOIf/37XzkwWRnEExFQzz0E9T7tQXT5EuZCe97tvkoVBMYEAnANoWJivfHGG4PPZK9evUbKfI3Je6q630PA/GVmPve8c4O/qsMXKR6+L9FYv37p18JdCz0/7UsuuSQHDda2ZaFFu/kA29mHuySBgf+9BV39srxtDs8///wQKIpRoO1+5tln4tRTT82HNZXlGvFq7QIb6xbGpnuP7mGXPmuTHQHff++9uPCCC8KBWGLe0BLPb7jhhuBHf+WVV2a6gsEt4WcdE/TMp9u2oOaDNVA9/t7mSFm2Ea+Er2223jrviIjHwOha8yknCQxgLziXD76g57vvvjsf7MWFBfzPOuussP0wPqKEnx18uMoYI/E7Dzz4QKbzF154YfavL8u1xCs4wGEb2IBl+Y3ynQ8ipsb6xw1IrCdmnauQQ9vsymZHTPwY1yB4C76EY3nq/fe//w30htu38ehhF7CLLso8YfkutIqbkvkghko/CCDiQsU0GBt0itJCHBVhxS5KaBjhwzNrcy3dKtuul2vDCwykPQTz088+iwsvujBOO/30vIiQ9uwGgSgKqrNVlsG0wNiij5RvYC1QiKFdCiDC9ddfH5CRlMrMZGGyeEFAxPO6667L2/ip58wE7SGgtDYQWTCOtm67/fYfLJD1gjRVP5oPBOA3YmeHGIvIZpttFgghLWvz+Yrm1VO0weKx9157Bya2b79+LX7BHhcjhC5bnJ97/rm8deqI73C4Zr8CttyTMLoCmDEGfOVpvWsVMbSCtOfawJgx/6+z9jo5eBfdld+oicCFYXI+kA0tllt2uRxsi6EBw06LLRbtppwyCwX8sK1V/3vzzfjm22+j9Mem1a0VGIydNdOuMoLJrY0YLvFvb771VmBurZ+NCnNCK5cuLr52MBR7SKgFcy7C8BoTaVMTOzkKJCdEqMc12MYs4ModuYQhhhmvYifHtddeO5pSU7SfoX0+ZRj+Y37LsmNwrbuq8Aj+EqAGDhoUX3/zzbA+ElIJWyuvvHIQDOwqhY9DC1ZcccWcx/UIvQBb1gS7TZkHgsyNySOFsIDGsDrg5Q4+5JAQK0EIMCbly6666qqwMxKc52aEF8RDWmvFPsw511zB+qBP3olWmU8sQARs77v6mmuinpVLTeXHNvIVU2/g7clNImzbtm3etxextPjY8eTBhx4KzyGOMrQmzz3/fBx62GHhwDcWCpYIv/nECmC5/bbbg3mXAMC6IDCZlqb33XeHXY0guV08ILqofNoECAbp/vvIIw2v+WpknBxb305gQPT4UQpYRMhSSlloHVvvqNoZHgJoCYYULTCX+XDTqFrYhi9Z3f0UBNDlnXbeKbbeauuYYIIJoxZ+8BpzxTee3zJGAb3WngUXE0wwcC/ZLtq5C7ZSVVce2m7nJOc81Jb1rJGStYmlnSaaAssOSJhZiq9ll1027MyHQQV/QaAEBrvs2U3JvvXWNGsieJZwMyZ2D7SeOafBmipOTv6MM8yQXSMbFeYYd/wCAQsfQJHDqgAP4aazAVhi8A60zhhLmnB58JpwrA6rWwlvVwwv5RAFJp5i8immyHE++A4KDIyqci0t9X/jjWCZYTHo0KFDDBk8eNgnppSyKzlLA5qMMe/f/41ALwi1KaV80KCx4K4Lj1loWAVKIcKZF9o1Zui5s2Cso+jMe++/P+xd2jAf4LhdrswjcyKllBVHve+6Kwh+dsMU/EyhbHzFZJlPhEdz0VgNa7TOflQCw3cDMrjQlkw+2eRhuz2SnsXewFuQBHj9r0BKBA5CWfwhB/ejueecM5zDYDHi7mFyQhLbskJQkxhi0uySWgW5PPLww2GbVFKqd9nqDxGxS4c2aV9oGQgd33Vv1C9VyQoCI4FASkPjT1JKYeG3MI2kWJU1liCQ0lB4l81V8C4hMepXQchzzTlX1nZHDBmuIu0rk//Ms8wStp/eeKONwpaKdjNhHcag1lZAzy3QteOQUgp0mkCN/taWb6TfmCkWgu223y5vkYpxYoVkKevQsWMGBQGC4szOL+D49FNPFUMyJDA61jZCMat5LvzdnwkmmCAwVlxraG61J2/Kdu0CzL33u6INdQFLW6xffPFFceaZZ4YNS3gyUBriCyh2aLkJcDwOuNFhYlkPeEFQTNq5B76LWSiB99nnn+cDYQlws8w6S1xy8cWRUgrjRVhoifA2b6+/7rqgpMHMf/jBByEeoFQe2AFt3f/7v+DZgU9DG6aZZurYdJNNsra/W7duwTJgTRTgTIDjQcLaRikMZz0zJimlwNNF8S+lFIOHDM4uX8VtXlNda58XwM8H4MojzCy73HLBsqHP2uzRo0e+Z2WgZDb2ExZzhmCirXpMlcBQjIrBKy7FkjSkQIIhefBTSsV4p+w3CPkMOkmQ5Mh8aHehSSaeOL748sthJ/gJ7iIcQAjJ4mThGjxkSJZimWRJkMyIiMaw9xbPTWbCBD837yqtDfpVpQoCvxQCKaWYbPLJM0GFk7RUBF+E9Je2WdX7aQiALRib65J4JnkppZ+uOJKnVRa+dChNHhEW6CicRmcx/vyGMVfcOLjDoKncATxXt6S3fpdJfUwsmlvmNdqVYgqzNfNMM2dr+XTTTxdgVsKXJvWigvmExxhZVhmabq60gjZZIeaeZ57sdgeecJ7FwraU5oGzhLwDc2sMvi00wGCeUmPOB/wE95Yvv/wq0AXMIuGYBQbcwYgLFyELo4rvUE4dwpw8dVxLeGtzhvbt8wFgnhlLQgJc1iZ+I6WWB29zfHDBuIMdfHy9/+vBVdG8L4XSGWaaKWxzyi1o1dVWC/BhcRfPsN1220XXrl1j9kIwfvKpJwNew1XK4glbt46mVq2AMM8HNIXVxzzo07dPUFRMP910OeYV/LVr3Ajf8H+uQplsvUWbuERt261biF0xjuIk7n/g/uB94nA+88S4S3Ahv7QO/1QCQzEoKRUTqfhf/Ixac5Z7KaUUnTt39jMjI58zggLNQEopDD6pnjUBIpJKuRsZfFqZOWafPWu/jj322EA0tWUCm8gaTSll4YTA0bt37yBkQEZE1fMqVRD4pRCAZ4stumjGO8Tp7HPOjqWXWToQxF/aZlXvpyHQsVh8OnTokA8K4uIhfoQrzE/Xqp7+GASamtIPHmEQOi3aKV54/vkc68XaILjxiSefzG6gXJAE+wsqZBH+QQPfZaDVmOVGprX8ujt16hR/+cvJIa5u4FcD8+nwLN5PFfAE/1defjn7e6MhmCDKLQxpXvtOPDELC9wtrIEXF8IFpglzJEhUHQwvaz0Glwa4QWGesY5wig848qijggVBfAF85dfO3UsCPzGPEl95vAY6csnFl2R+g/Z7jTXWyJ4KtOKYUB4L3JrwGXgJgjMeA4Orbj0zohkwv+APXmmrLbeKHof3yAH488w9T6y00kqZJpxxxunh2/v26RN33HlngEn/118Phwxi6NELDH6fvn1jmWWXDQIYuFLWculycOGCCyyQhQVCMHejDgVdx+tdesmlIQbK+3v16hUEOR4kxsHmAYQPBxcSpuG7cWZN+t3vfpcPMuRONukkk8Zll10WLBqEG30leMw777y/ABLjp0rDCwzMfExCiy+2eNgRgvkOASV5kuyZWyEYcxVEQEQFFG2y8cahHOSBFA7+EaHP+sDnkGuS3QwIDCTbdddbN/gmQkZtMZ0juqTZTTfdNLglMVsJgPKcDx3XpvGDBtVbWioEUkqB0Am+pRmE65tusul3bh4t9at/3e+yh7dgUAsXjex+++2XXTd+3V41z7cTeFdbbfXYZJNNgsa7/ApMl8Pb+Alb/PnYC/acs1DOsDSgwzR7Xbp0yQoY9dBzu5OUCzLmlkZREKn2lGnEZM2DrxgeTD18Ldc5zOy33w4OsQvWOILv/gcckN1o+GGD9XwFg3PA/vuHc4AozDC3YP+Xv/wljIv10Xo288wzZ1ckmnPvMbaNCG94jFew4xH+gHsRXHYWCH6AhhyzTxjDY3Tr1i2MDf6BAIxX4OaFXyCIgTeXO0G8hx9+ePCRpz1Hf3g1cHHu1KlTZohbKrw//+zzIMCKm4HPmHQWAS7kcHGB+efPQgS4cf3B96HNYhpWL6wOaPZMM84UXO5SSuFZp0U65Z2RWCtswaxN9fFleDdu42iIMeMSRclrrNyvvdba4QrH119//ey9Yh5wQTdmdhczX8wJ/eXiTnggMLiv13FqeIGBVGmC8cVcZull8qIEofhemtiYLAhHA4XxMnFXKxCMhsQiQ5vIpEW7AmEgg4mqLMZf+8quXix6hAGEmHYMwTTJIZR3ILT6QCrl32hR86xeEafqV/OBQIm78K9L5y4teuGoh1FJaehhVZglyQKT0g+15PXQ13rvQ0opHxSGUR2RHi626GKx3PLLZ+0huosur7/BBkFZQ5vKr96ijt76TnkYJ3SapvuKK64ICz9a7XkjJxbHNddcK6xl1iiwxsRaX+39iQAAEABJREFU3+4qrN4YKveYn4UXWigrHKxt1jprIu249ZJbBobWeFjfrGXWNK681ksBux0KLa13NDK8wadL585ZECCwYi5ZAVgJ/nPffcG1mSBAI925KEfYNSb4BvDm5oWxBHPCMd4BnTcOntuNivabNYjFAp6r39JgzotDoLediY488siwIxKLFsvMAw88OMzKq0yfwtIglkE5W5mKF2VhFNxPGUzYEoejHA+RY449JluAWCgF7lMA24nKDpisZwRi1hxxCbbGFZOgLfXFABH49Mvz1159LZ+HQWHMIiRehQWUhcO7BLFrz5xxX6/j1PACQ70OTNWvCgIVBMYMAlXtlg+B3XbdNZZdZplf9KH8ivk2p1QJcz8GQNYGbhkYsx8rMzr5nTp1ClpYzGxU/34AgTXWWCNslzq2mHuChrMBOhRC2g9e1gIyCKGUtRh5QeLce/wWzyA43FXy29b2GHvl5Clr22ZuSO7l+y3PM/cSzb+zFS666KJwro7n2qutI1/Zsr6re8k7a+sIVnevP5K2tC342rt4nNTr0FQCQ72OTNWvCgIVBCoIVBD4SQiwzLIQ0K7+ZMERHrI20LqqP8Kj6rYGAlwmWANSGjtCFW04V5GaV4zqz4YoR5DqtMgiOTZhbHyw8eMtMbYEkLHRp+bWBoskyw6aMa76zrrEMjeu2h9b7VYCw9iCZNVOBYEKAhUEKghUEKggUEGggkAFgRYIgbEnMLRA4FSfVEGggkAFgQoCFQQqCFQQqCBQQaDRIdAwAoN9bp3YV6Wvo4JBBYOfw4HqeYUjFQ5UOFDhQIUDFQ60EBz45psxlncaQmAQsPXeu+/Gq6+8Eq9VqYJBhQMVDlQ4UOFA4+BANdbVWFc40MA4gPft26fPSM8ZGx0poiEEhpRS2BZulllnjZmrVMGgwoEKByocqHCgwoEKByocqHCg2eHA6POxeN+8vXfTmLH8Y1Z7dESTX7ls6zZtYuJJJvlBmmjiiaNN27bhOrLntXnK/Vg7teV+7d+j8i2/Zh/bTjRRhjd4+v1L+2IsJG1oq2zH76ZWraKpVavwrMxXdoIJJwxpwtathz1TxrOyXHX94TypYFLBpMKBCgcqHKhwoMKB5okD+MIxZcObxrSB5l7fqZP2wHUi4E99ixiIm2++OS6//PJwGt9Plf01n73/wQfhZEenHv6a/fixd4Od00OdkHj77bfH448//mNFfzLfCZbG7YknngjHsTsoRduOV7/s0svi4IMPDgep9LquVzipETzsz3zqqafmw1jOOOOMuLbXteGkx1deeTUc6KLMT750FB9WxSoIVBCoIFBBoIJABYEKAi0JAg0vMLzxxhvhND4n/tUO7DfffBP/+9//AmM7YMCAGDx4cPTq1Sswqf379w8CBiGitg7mkwCCae3Xr19ow3OMrPdo67PPPsttffjhhyF5B4ZWvudOZhw4cGAWSrT18ccfhzxt+92nT5+oZWzffPPN8K6yjkNAfI/35diN996L2jqffPJJvP3OO/nbvN83aL9v3775nfr7U0mbn33+ee47mOm7kxC9w+mU6mrTd3lewkC+Pslz2qervvgWsH377bfDqYdOpczvKODke8EEPJXRRpmc3EjgmLUwJz777LPhNEUw+utf/xr/vuHfYb9vJ77+47x/5DHzrQ5RcTLmHHPMEfa7BicnO0466SRBiHF6Y9l+da0gUEGggkBEVECoIFBBoIJABYECAg0vMBQwCAwuJtVvCYN/6WWXxdbbbBNbbrllHHbYYfF6ISRgNp9//vnYYYcdYquttoqrr7lG8WHp3nvvzc+6ddsmNt9886DFxshfeNGFuby29t1338AcY+x/v912se2228Y//vmP6HH44bHFFlvEtr//fWZwn3vuufjzn/8c2xVlNi/yd9p556G/i3ZPO+20LDQQYLYp+qgvPXv2DIzzP847LzDBN9xwQzz44IO5jnYxxxh7+d26dYsti/6zluiHe+0cffTRWeM+7ING8uPrr7+O66+/Lnbbbbc44sgjYueiX4ccckjsvffeoV9g6f2HHnpo1vCfeOKJuU3v3WeffYKG//7774+UUhBUWER63313aOPkk08OZV588cWs8XdCpX7vv//+2WpSjpE+gPUyyywT0047bRbAHKpCcLr51lti9z/tHptttlkegz322CMIKAQ849elS5dYb7318mmabdu0zUJK+/btY55554nr//WvkXxxlVVBoIJABYEKAhUEKgj8P3v3AajndD4A/Dk30wg3tQWZRs1QSs1Qe8ZopVpcW8yYrWoroTWrtNr+29KK2aFKB2onSotaRW0SsVekVpCE//s717k+Fy2t3Hw3+ci57/e+75nPefZ5znkbEJi1IdA0aw//g0fPU06ZHbzCCrHZZpvFH/7wh7jj9tuja7euwSs+dOjQ7KH+5je+Ec9U3vpSizKU5SWXXCqWWHLJHBZz+x13VN78J2P11VePNdZYIy644IKs/PJmX3vNNfH5z38+Flt0sZj04otBaW+qFOlfVcbKoxMmxOVXXJGV7fUqJfcPv/99rLDCCrHsssvm/lC6DzzwwPxFyM9+9rNB2bYisdJKKwUPui8TUr557SnIvOsMCH285e9/j5VWWjHmmWeeOOGEE/KGcIq01QrGUhmP3/JbUeG995yn/4H7H4jZZpstDj/s8Ly6QVnfZpttcr8eeuihOPPMM7OHf88998whXL/5zW/yuLfeeutsUPXo0SOvZtx1150hv7R6BRuGmJWKv1f9u+uuu4KBcMghh8Tss88eVhQYI/rw7LPP5nJrr72225y6du2a+zLljTdj0MBB0dTUlJOvXGrv1ddey0bWfvvtF+AB7nP26hVf/OIXc77ll1s+brv11rDCkSts/GlAoAGBBgQaEGhAoAGBBgQaEMgQaBgMFRhSStnjXf3M/1JKsUifPjnshmKfUsrKq/Cavn37BsV+8803Dwo2JT0XeufPAgsskL3bXxo2LHrNOWdMePTRWHSRReL5F54PqxOUYIovxXv99dePr371q+GT4D6Xry2rDylV7b31VsxeKeVWBxgaPOnaXXXVVfOKiHwMG7H8flOKu3Tpkg2VAQMGxLzzzhtPPvVkvPX221m5bm5ujmcqRZsizZjYd599Y6ONNoqNN9447r777vhj5V3XLysi7wwle9+Nc1g1Fh59ffZOW2tVyvqSlVFEIdc/xsyiiy6aFW4hRAyNm2++OZZYYokQ0kWhp+C7N94uXbpEt27dq9Qt+vfrF/dWKyqXXnppvFmtYMirn/pXjJ/u3bvnOdC+8C2rJb3mmsttTvo299xz53l8+aWXA2wYcy9MnNhWpzoYNptuumn4vXVl+JlPFcwxxxwhBEq97hupAYEGBBoQaECgAYEGBBoQaECgFQKzvMFAgaeAXn755XHOOefEL3/5y7CB9ic/+Un27i+33HLZA00hTSkF77bwGl7whRdeOCipraCMoASL6bfKcHW1ejCtUtZTU4qf/exn8cbrbwTlWl51uc5VKbx+i58///zz88qA8BjPKPpSU9Wme8aKMsJx3PO68/LPNvtsudzgwYODwk7hp6wLwflU70/FbD17Rr9KIV9qqaWCocAoEL9P6Wds+E2BHjRoUA6FsmdAO5JjuIQKCaOyHyCl5HFoXz1u9Ivy7Zl79X6qWrmg6DMQwIhSrt82KIOf/QvKK6O/F154Ycw733yxzjrrxFvTpmWDyLtpldFkfrThqn5Jn429rHp4px5jtKdBiBdj5ZhjjonjjzsuFqyMuPkqAyqlFFZSdt111xxSJWRMPnWCBaNBct9IDQjMcAg0OtCAQAMCDQg0INCAQJ1AYJY3GITTmAvx90J8hPHwuDMU7CP429/+FpRgCuWc1YqBo6m+d8opcd1118WIESPCyoDyUkopK9M2Rp9/3nmx0447xtprrZ297BRTRsb888+fvfCUXiFBKaWs0Pt94e8ujNffeCN7ySnMvZubsydcH5t79w5ed+XmnLNX9OvXPw444IC44/Y7gsJNaW9ubo5lll46KP033nRjXr2gSDOCXOevlHLl5ZOf0k1xt2H4vvvuy6E6lG5jkXpXbW677baxxRZbxCLVKklKlcFQ/WOsgIk8c1Yw0T+rApRt8Bhaee6dKCXcyQqMMCmrBSeffHIceeSR2ehSR69evXJIVf/+/eOmG2+Ms846K4+Rl997baSUQj/1W3uSVZwFF1owbqzmxr2xyKsv9k4wSI6rDAWGm30dDELzx7hLKeVVDSsNwsTMu5UFcz1o8UE5TEudjdSAQAMCDQg0INCAwCcFgUY9DQh0dgjM8gYDr7s4f6cESRRHRsMPf/jDvFnWnoObbroptt9++zjqW0fFP+64I6668spgAOy11155VaEggZh/Svb//eT/4s477wxKK+XWCsOYMWNy2I9y6vrpT38a3/72t7NxsOaaa4YTf/74hz/GlVdcERdddFFsWSnpwoC2qpTvIUOGxPV/+Uvw1gtR+v3vL47Bg1fIm6IdS2pF5Mc//nHeAGxjNeX/iK8dEdttt13up/f2EVD6hw8fHqNHjw4hSxToU089NbRjhcUqhw/clfG4MlKklCpLoXpgo/A+++wTX6jqtqLCCOC1Z2ioi8Hw5R12CJup7av4xS9+Ef2qFQ6bwNVvE7TxWX04/vjjY/fdd4+DDjooTjvttDj+hBMyHFpaWrKxM6yCOUNgp512CvsfGCZVF/L+kTXXWDP02cqFFRIb0xkswp2M74wzzgjG3pgK7l/60pcybBhy9oCogxECZubZCobVj62Hbp0NFu8bqQGBBgQaEGhAoAGBBgQaEGhAoBUCs7zBQOkVGjT33HOHq8RjLVH23fNc83BTMimlzc3NwTCgSLeCsfUvT/kmm2wSiy2y2HveU3qtLBSPurp40F2VTCmFd9rzTHva94ySzHvvmfY81we/lW2u+qJuz90bD6VfnpRSHpP3+uC9q7ZTajUA1MN4EAqlHXn+U1JHaQ9MlFOP3ymlrHSrU4iU/sc7/9mHwWjRvn4aa4/u3fMqCmNI2JA6JG2Ustoqv9+pKtZbb71YcqmlskHknbpSah2TssKprNqYJwaFe+3qZ6nDb0aT8C1zt9Zaa5VXjWsDAg0INCDQgEADAg0INCDQgMA7EJjlDYZ34PCJXCicRx99dCy62KKfSH2NSj4cAgyoEQceGGVfyIfn/M9vGAs2lDPQ/nPuRo5OAYFGJxsQaECgAYEGBBoQaEDgE4NAw2D4xEAZ+fhPXnQe70+w2kZVHwIBKwjSh7z+yI+txliJSKl1heIjF2xkbECgAYEGBBoQmO4QaDTQgEADAjMeAg2DYcbPQaMHDQg0INCAQAMCDQg0INCAQAMCDQjULQQ+IYOhbsfX6FgDAg0INCDQgEADAg0INCDQgEADAg0I/A8QaBgM/wPwOlNRx7Q6Uagz9bnR1/8MASc8ORr3P+f8GDk+wawzG9755geY/zsQyfPv3sodezMAABAASURBVE/Pd9pG567Ts51Pqu6P08+Pg0sfp97/ZixoDpz/m7L1XgbsjM21I/v6cdqbEf3rSFj8u7bwH7Tw7/I03n2yEJje+NZZ+MksbzD4kJhvBjirH4q99NJL+bhO3w9wPz2SrxA7RnX8+PHvqx4jcLSrY1khUcng2bXXXltuP/b1L9dfn08UKgWfe/75+N2FF+avGzt69NFHHy2vGtcOgIC5dyxs+6Z8FNBc1z6HB47jHTVqVPjYHJz1Hq762OALL7zgNnzZ+k9/+lO89tpr+d7xuo72dYTv0888nZ+VP4TO5Vdckb+LcfbZZ+dvg5R3tVffqIAfpU7ftXBsrWNzHZOrntr8Y8eOzccF//73vw/f/vAhQ7/VU5uvo3878hhsnIhV2/b9998f6Epf2z8HO8fuPv74422vfI3cEbxFuTGH49+hnZdfeTnO+PkZceyxx8Ytt96SP0BYCk6cODF/GNIRy2eeeWb87ne/i6effu+cyKsfvvHy5JNPuo3S71HV3PuuSH7Y7g9eZY58a0R5fXrwwQfbvozeLnuH35p7MIavpXE4DZY+MlmeuYKrvjt++ZRTT43yXn5HQz/00EMBNublxBNPzN+cUa4k/NNR0+bOxze1Xd7VXtGMr9uDr+ePPfZYfP/7348TTzghf+Hes5K07Rs6DrT4+c9/Hi88/0LAa3TgmzEl34y61s5/6QN6/cMf/hDGWZ65otdbbrkl4CAaRhOvvvqqV20J/B3FDTbmA42AKTiUTPfee2+Mve66ctt2VUa73/nOd+Kvf/1r2/P2P2677bZAR57DWfj7zW9+M/Cqwt+8o6h5h24k3xRS9sYbb8x0K8/MlIwX/TsS3FyBv+8KFfjTUy6++OK48sorw5HmcNLx5WAt/8wEi48yFvC5p8JFdAk/yDL6XC3d4zu/+tWvAg+9vtKD8IhSN1lLttY+I0d9m0o5+caNGxd4Fb0N/8F3tPdBtI/POS4fDzaXaMax/J7pg2f6fNddd8UxxxyTj59Ho2QBfmJ+tVmvaZY3GHzkjBJGoJukZ597LiAeAWJiMcA33nyjTfhDAJOOyfmNSOUpCFfKeOa3Or1z/+aUN0N+iIZZYwLee1bqU+cNN9wQGDZGri159I+yoy751eddaUMeyb13kvfyUyQuqRRJ5dx7N6FScr5dKTbqpHQyUJRvpOkLAfMD5w4++ODwHYjSmueYjNOazL/78u4f//hHZi4ppWzM+mYFhQADIiic7qTOXXfdNU455ZQw3xStnXbeOczvX67/S1DA4FOpk6Lgw4OODf7tb38bvpcBB8t77T9X0cKee+6Z6yyMjED3gT3GiO+XyFfKYIy+0YFZ+yAeo9jxucZDSSn5Ovqq75TBPfbYIxtVpX106Lsl6N/v8hztjxw5MiiGFH8GgDERHObMMb+EB6XVd0QeqpRzZb/z7e+E739QeL5x5DeyYuu5BLaEk8TQOvzwwwNNe1cS+vStkEMPPTS05TlBRSFAs/vtt1+MGTvG47ZEqPn+CYFknOBNob64Uir0sS3jDPoB58DJeMFQN+AuPILrj1Z8yLOSJk2aFN859jtZafftma997WsZnwl1yiJcL8ooGIG/8ZbycJYg9gwsv/GNb5RXbVd5fLeFgmpeKP/ghx8/VxnflLAnnniiLT/lWH7z8/tKCf/xT34cjpLWJwpKLQ20FeqgH2Dqezb6bP416xl633fffd+HY2APh30LBw3jG2SOcpL3DDO46djpW2+9NdANPDR+YwUP3875daWEKVOb0Lz5RgPmxkdQa9+TP4wv3wMi47xzP7KiN4eFUPbQG7zxTn5zwVGhXTyOA0JeY6RsyTezJHT+61//OsCHEgneeCfZQJ7DeUqpj7Ve/uc/54+aMuh8E+rqq6+eWcDwkccBPi9Wzhh8FRw4Cn7wgx9EoQXwJK/oWymlOOKII4JTC16RV1/4wheCk049GsUPyEL5GA7uGcBwED+F9/DQHJG1pZyyjFi8G+3gUebNHPoNT10ZGgxAxou+XVzxabLJUfKMxI/ATzQ1w9IsbzBg/BKhAUFefvmlcI4/wUtRg4DShb+7MAuu31ZeeQztW9/6VvZIMS4IE4wOQ8UwCR8I4RkiZ9UqwyNw0kknBY8QwefbAePHjw8CX36MnMDUPuSDkCdUHi9MvXuPHuGbAffed198r1IK1UfgsXij5j+Kv3fKESL/vOee4CE1niWXXDJ/PE7/EBGm26Vr1/whtK7dukXjv+kPAUwHAyIQa094IljPO++8WGTRRaN2LuAPxtO3b99Yf/3184fuPve5zwUGxEu922675RUFv+Vtbm7OHwMk7PcZPjx7+9dZe52Y9OKk8L6MEM5/q/Lo+UihjwHCI30r7zFczA1D9E2NlFJgsgTW5z//+dhyyy2zUINDpczb1Q9MEdP0QUSMEZ7rLy+hOqssHfpP/yk9lEEfECyNU7TRIlgzmlJK5VX+GOOwYcPi8K8eHl/e4cvx8ssvh/yjR48O45LQORr1oUK0BTY+GvjD034YhBB6fW3y5LY65cNH0Pnyyy8fYDRo0KC2934Q+LyLvpuiTvyEMWfet91229h///1jnt7zyNqWLvvzZVm5LvNuPlZbbbUgPBmLbRln0A9CkGD2nZWUWmEM1z0fMGDA+3pFiL4x+Y2M64w5Y8Avefy22GKLMD4K/4EHHphX2+AXBapUROE155tvvnnIzyCpVYjVD84U2nIymve+nwMfttl665j21rTAh9WpLvz4gAMOyPi+8UYbxbPPPOtV+KAkw5sykR/MgD8UecoS/ELz8JAhQ8HGM/S/tltwGR0a75ZbbRlgDP9LHsYyGofLYER5Uq9v2MiDDnzM9LXXXs2nAnpWmy695JLYbLPNsmz0cU6KVe17fAv/I/vAVX+lfStj+GuVMkfxBU+rdcrJgz8xmn10c8iQIZkHrrLKKrHYYovF2dXqqHwzS0ophe8owWNy2hUMwMsYfWQVHOgCm1Y4jn9zIDG+OWngt3yzSoKba6yxRl5t4dzyLSvOOPwGDDjP6EQMTc4DvBTvhuecO3AILAud4Ol4MH7KMQRf8VIyDE3Bf7oVg2LMmDFZDmtHIoMdrQ9Xt9pqq/hj5aT9e7Wa59tTIyuDmJ7I2L3t9ttDPw855JDAc6zoaaelpSWvHOFv6qvHNMsbDBDu/gceyKsKFPcf/+jHebkZ4Y0cNSr/7rNwn4oxnRMsy79Vy6w8q4Q+BR9CEjwEGiTk7YEgSyyxREYG3hOeMUrXoIGDglcYQmiX8LNsrpwPkVlm5N2h2KWUYvXVVw8WKk/ZA/ffH5SecY88EmPHjAntMyQo/gQe5MJ4ISDkX3zxxXPYA6UNA6acMoggM0XFvXzKNdInCIH/UBUm9MUvfjEwtyIE4APBut1228Xaa60VU6dMaavFHDFmzT1PCFziwYCDcIhg902KHXbYISuUcEcZH6ojRBirGBklVNul4o033ji23377oByod4UVVsgGARxRP4WVoGYYO3YWbsF1RsX4yshlTFB+GT6lzlVWXjk23HDDMBYKIQVdPRQXOEj4lbwdeTU2woKCCj4SpUV/jvz616Nb9+6Rmt5lhZQvyiZBQwgbf0op0x+BAO6f/exnAy0RTOjPM0r9vPPNF+jVHM4x++zvGyZhhKbBXxnKsFVNsB08eHCMrAQLg4SxwLtFaWPw4BvZM/b2W++pkzHI6+XDi+bdS3NvrvEH9zMyrbjiijnsDc+BQ/qy1FJLBWeHb6gYp2cl8bTNO9+8gQ/yvOFj5gv+rLrqqtmYSykFZw5YMigowaVuyq86hNwwttAHXv7c888HOpOPwUvRYmy4xwsJeLyS8jVt6rTsnNGnlFLo+0aVocDLax7wcrSLB4M5Y1veGZGGDBkSVmHgrPZTSrFyRYdfr/CaHGoPX/QKHmSZlQDywoqEshI+Q4GC15Qmytc222zjVU5gS/nadtvtPjDkbdK//hWlL+jt0QkTsgyFx9oBc6uQ6KvQDTnHUHv2mWcy7Sy33HIxV6+5cnvlDz5lThmKPgiKr1AUrbDCj5Kvs1/hExgxnKwAcSLhExJ44QVLL7NMcPS9+Y6cQOtoA1/BRzo7DP6b/hs3fsyQZKim1Oqc4Biba+65AyyFwFH+8QE8HQ/Cs1NKGZcfGTcu4NiwylnUr1+/7JwYX8k6PAJO40EUffQBBye//nq1gvdiW3fJabzCA/k4aul2eDODm8OWwaEez+h/eE9KKfAwdIs2GSbqqMf0rpSsx951QJ8gQ9/FFsvKE0ZImYMQTz71VI6PhYiY1eyzzRaYLeJcc801Y5111olPL710VpAoERgphPSe14YyRpEjZDA0XxveuvJeEWAUgZRSDnOi+GH6LN/NKo+B8A0eBfm1QYmEiJQbzCSlFIiCYqauJ558MiM7UOkrBN+wEm7KQVDjg7gIAEPBeHjfCEhCryoclUs6WskrGv9NZwh06dIlCGMMRFOEAI8HbwVGxlvIA0uR9F6aOm1arLTSStnDucOXd4jrxl4X4x4ZFxQXTAe+qBPumW9lUkqRUgqCxCoEhkm58k7CSCk6lE1l4T2jl5HA04epYYrwGt4pA18o0FawvvrVr4Z+1jI3Y9MXeA4/eVP0hxKnDvipno5MKaWg+PDaaVcfjfvM0WfmlTUK0oOVw+Dhhx7KBpM8KaX8tXIwBx+KDsMfHTO80BCB4LfxGVtU/3m+4AILxJ577ZXb5MmuHr/nH+ONEg2248aPi+H77JNDPuAA4cH5UAqoV5sbbLBBUNwoEjza5b0rwQO+fpcEt4wZ3ZdnM+pqTPDUWEof9Nezcl97haPC6XbZZZesCDN6xPuaN0Ieb4ar1157bQjLUK93KaVcDW8dmFFKR4wYUdHK2LjgN78J4Vy7VqtxcNa3cvDmXKD6k1LKtMKAoZCmlLJzSN3V6/wupRSMBmE+aBRsjcP4KMPyzYi00EILZVyr7SscMv8f1B/GO8cYR8BR3zoqGKFgVvKSEWCMr4C3/H6X93gMQ8S1tFneueIrKSU/Mw2ZC04xMlEIUUopGxTqLOWVAdP9D9g/r1pwpuA7uZLqDx4pfIkhTFZWj/I/Mo2iRQnLD2aSP3jKMpVRcNjhhwd+y/mCr6IL8Fz8nZXJVii3DpojxwovHtT6ZNb6C38YU8Lg4GYZPTza4UtfyqG5okHoUmiDLLO6IF9KKe8VO/m7382GBdnLeWBl9Kmnn856mvxwFnxTaoV8/pv/RKVGvd3mzFCn1FTl696tW+Yf7lNqzdyta9dMG55JKbU+x7fRAt3T83pMs7zBYFIwft4Q3qwlllwievTsESYVkhASLS0tsXHlkSXkETMB5dprzjkDcqaUMlLMX3kXMS9Cj5IBOSljiBwjtuxEEVMes3RNKWUPDMvykYcfzsy/5GdYYBLeQSR9lUo5v2tTt+7dstLz/HPP5aUyffB+fGU5L7TwwtG9R/dsyVqS9g4jrjoeb7/1Vrzx5puB6Ug08b3VAAAQAElEQVT5uYKNNN0gYP5LIuAZgffdf1+Oe+eVgEfmH571bm4OCg487TVHr3ir8jLD0fbeQ/XpcEopKLjiYHv06BEUIc8nTZqUGSP84mmxAgEveCgpCauttlpW0natlDUKsTLqlPzm1RUml1LKzFH76oef6hQ7aoVNWcYqAyiq/7zDaOWtbmfIP2OQUkrVikK3vHr32uTXQrgX2nz2uWczbMCc4LHkbHxWCvUbXRAYxlI7AHW6956ymUMGKmEvtIxSiZbAR77x48cHw81qIhpecIEFY//99ouDKsXW6oJn6pLXlQBhlOAxDB7CT58k/Sz5ylUZCc7opzl1P6NT+/7pj2eS35L+ghPeBA5wliPGWPAq/M9vYzcfPOjwFnwotZ5LeGxzRS/KC7uZ+OKL0dy7d2Uw7Jvh3L9/f83lpP2UWo0DdXHKDBw4MIeEcA7pDyNX2M+JJ52UlVleQIXlVV4e8+RZPSV9k0qfwBd8br/j9hg9enSAZUqtnlWwLfmMBc6Wsq4llTztr+oq+Aj2lC33DL2VVhwcW2y5RdjDwpuLhpRXp6uEJoToDRwwME7+3snBCPMe7NUNJzjjGM5ksjKS92gDXbifWZKxm6tNKp1j6NChweCCZwyHhfv0yfgJLp7hO/QM0QmfrlbuGHkzCxw+zjjIJryaDqcc+IANOIITJ85xxx0X+GxzxR/gjXxg7Qrn6X4rfWalgLdPVo7YBx58oFLsU5Z16qPL4eHeWaEjtxdddJEsN7zHo+GpduVj9OE3HM5W7RkgjN4BAwZkZzQeI2QS/XGglL4wMqJO/5vlDQbCCcNJKbVOUWWmz9Zzthwfuflmm4V4TZsUef4xKwmyUYCUczXhhJilQt5DnpRjjj4mKE1WGjyzsVIMGwNA+VL2S5X1y7too95dd90ZlDh18ahQwCyrb1wxDsJf2xiua0opXGvDHrp3655jUi1j8iBBVN6vaZVBsGDl+Vxh+RVCXyh1mJB2GEYppfjpT34SvHLipLXdCozG3+kFAfNIOMMdRqnQAPH/VpqsAPEc2vMipMhKE68Hb9OPfvyjsBQvjlX4kFT62L1792xYRPUfpZ0ibNnVXFOgMNQzzzwzn/hgs5Wyb1TLqoS1eE5tap/hwDipqqkYZlNWlFJKQTGjvMEtfRNKgEELwaEoC9O56uqr82kUwpzE8qeU4plnns77guCbOmdEQqdFmFJMRh41Mk44/oSg5K+77nqx2qqrBW8rgwjjn/jixBwXe1LldaLAGKvnPNSFsRtHr169whwaG5gLUxR7/MTjjwcF6a677sqx9gxAtCgPOJeyls+HDBkSiy66aGW7p5zwBnXqM087ZcA8Ei7CQxiDQsIoTOppz8PgimS+vJ/RyTiMybX0JaUU5gMdENZWTsSj6zOhCmcpmXBW/LAx4mcEs1Whs846Kx8EQMFnbFttgNN+UxJ+cNoP4oADDsx7IRhoa625VriaS33QF0Z4SimsOFCohdgJSVJeWIzDIEqf/nHHHTkuH41SBPRTf8DZ3KlzRiWwAd+UUlsXjA98vaO8C6UCY2O1qg3PjRevAeNSkMyCp/DVs5RSpl2yxn1J8F2b7jnIyCqwgJ+UJgYYRXabbbaNZZdZNs/D4MGDMz9RRnkJrIUVcZI888wzcfBBB2d6mTBhQg5ls8LEOIMj+qZsSegA7PHR8qyzX1NqlevmDZ/Za++9Y/U11sjOPPOGxxoj/vznyy6rcPyAsOr1WMVvhNmZd+9npcQgePyJJ3LkRRk/xyz8duW4OeP000MI3n333x+iK8hKMHLFg+Dy/vvtn2mcPBS2KMx38UGL571/HBHonv5khf3Xv/l1WEl/+623cxgTniSUCS18/civh5V3q+zCYfXJyUoOGqAPCmVET0Iu8Rvy1krxhEcnBCfW0sssrWt1mZrqslcd2CnW3gEHHJC9GprlsaI4W66ypC1MaeVVVs4hAZitpVXIxCJUjtUpbg1yEUAEO6/A5ltsHjYdQ0iMG1JANoSOUTp5glCyedRyOUbwne8cG67rrrtuZpaQDeOlUFJYttlmm6zwu6pDHOjeFUPBXPQdg/GbgOUJYwELt2KUEMIUHjHShARF5NjvfCdvvrEEjOlQcNRtPOrr8DQLNUh47rbbbnnEKaWsdDL4xK5iND2q1SAeNcJ8qcpzZIMURuO9cDMGgOeYUK6k+uM9JQsewl8xnZQkDBKueg6PMD44QLkV3oHxCV3COKtq3vMPI2tpaQleGcoWxgfvGAO88PBbWYaD66mnnBJwneGpbsrKPffcm/EWHbyn8g680X90ht5TStlrZLxocu+99wp0CaZoG+yccjSkUuQ3WH/9EJZEQQQnBhxFKN75j3BBxymlMGYJHI488sgAE/yBUUBAUG4ZW+D4TvH3XcBIWFhRjvRH+8IgCSpt9evXL9yDvQooTejZGCjUFAv8yTi8n9EJDu244445hK70haFlBQwuEqhwF9zABg7DWysE+Cm44Wc8/eCIbtAIHLY3hTMFPanDuK0+rP651SvnyZfzqSjwvrRbrvihuVOfMtrEt/UBXsMTfBS9wAvOHiGglALyQZ1XX31VmKcZzS/NM7kEpmV8ZBVj2DgZn6tUMgys+/frnw16+CN8A1+oVbjtnwETYUpFnoC1EFn0UurHm8ype/Ans+AumOFV5s8mf3MnT/tkbiVzzyEiTIoMNQdgTlahN3NDjg3fZ3hwkpR6rF4yTMir8mxmuPaoVoTxa7gGNgtWjj6hMvQEcnzIOusEuh+2/fZZR5AX7R937LFhfmcGGHzcMdB5vviFL2QFvpSFM/gDPKI/oQ88ApzgeMkHT23SRyPg3a1rt8Bf8fH555s/hN+p45577skODvwIju6+2+6BF5gL+IoH4z949LpD1g3Gm/lAh8J3tUOXIzvVifcoR7aaV+1fdPFFQd4P6D+gdK/urrO8wYDZQSRM0uywNE085ksAY4ybb7Z5JkaISUmDHPJT6DHJ5ubm8BxD5UGEoFYFKAsppXjl1VfjmmuvjUsvuzS22nKrIGQwP8hUEA4iUV5SSjnGE0OH8JBKHl5JzFcZV30h1NSTUqtnKaUU+sDba+/EJptuGpQeSKi/xkeAYP6EAMXOeI0D0UiYuGU0eRtp+kHAPNYyrtISJoOhdOnSNXtMKAPmGn6ZH4wHbppPzMZSrJUE5QlXcffwxb15hFdWDeBlSikonBQc7cBRuKBe5TAt5WoTZUI/S536pgz8odwpoy40kVIKuKRNeEv4WZHgsaQ0lzpq6++o3/qib+i9tk2CRf/RDVivssoqAd7GgxYkY1bGmNGhc+ApU56BG7j7bV7MD3iCmXo4INC19sFL/n8HB/DEH/RLnfrFiQCm+u+ZPuBR8rqnvGpPvZbDCTdKWKlDnhmRSptwCP7C2fLMuOAiYZxSCjzNfUopr7bATfwPvyLIwf7V117L+2bwVffwEHy9Vz8+5zdDzTt1qL+0WXsFM0pZgSH6kF85fDWllHm+PqlT3eZVu+abx/Hmm/+e9xWRAbV1d/RveGf8YFraLnzdOOHhUkt9OhuwxgI+ZSzKljKucEYoGA8pY19+tECJ8lseybOlKkeG39pg0JlnfUBD8BVdef9BSX2McHWae3AFe/1SF9mrH2QrvBm8wuDQt1KXVQmGHDlZns0MV3MF/+B1SinzInDGE9A/fAYzPBy+ghcdBTw9j1nwPzADIzAow4eTVuLxe7hE/sBJ+VJq1ZfkhcfKpfTuM2XRPZ6tLPgKs7Oii/fAU3qVfPiHvPiH+vBl7eDz3pmTQm9wFY+Wj2w2dxxCcFyYE0fP3nvtnY/Klace0yxvMEzvScG4999vv/jxj34UP/3JT8NyFSScXu1SIp1xbvnt6FGj6hr5phcMZpV6CWZHvNUK0nobO+WKZ4XAq7e+fdz+oGUeJF7UlN4VMB+3numZn3JlVZShQ5BOz7Y6sm5G0inf+142LDqy3Q9ri+Im9JQS92F5OuNzSg6v9Zd22CF7sut1DJwgVpcodfXax5msX7PkcCj8lHpRGPj/9AICA9HqPeNjerXxSdQ7yxsMYigt4wMmr6FYVlf34ia9d+W5k9x7V5tYnjxOH/ROPkyYBbrgggu6bUvyl7Y91I66/C5JX7TrWp4pJ5++1pb3HoLzXmvLb88aaeaFAOOT0IQLYn0/ykjl5T2sxamPUq7kUQ6uukradV/e114pre29mLXvO8NvY0SDaI2HiEfZb5vWaseNLuX9uGNSRv21ddXW4XntfMlrDmvzlN9oHrzxnPKsHq9gBW8+Tt/g0kcZV4GnOfo49X9YXrDGb9Vb8uhHc3Nzua27q7hu/f6wjsEneT7ofUopunbpkvfTGLOxw8EPyusZOEt+f1DyTmr/7sPqhBv6p23pg/AdDaLF9nXOqHtjqR2jMYDbh/UH7I2r9r0xlzLeu699X/vbe6n2Wfvf+gB+5Tl8aN9meefqneS38TiByu+ZOYGPsboapysYeOa+JHy1/AZ3sC33tddSvhYXyjPX2rx+T5k6NTxPqT4dUPpYm2Z5g8FGOWEdgGIp3yaU8ePH50m0GdnxfX+78W8hxlJMOM+95dCCMGKaWYZiXG38snlLXf8pMTBsRLPRS15LUo790sbVV1+dNznZWe/DOTaY+ggcRJXX0pW+OZNfrKln0fgzU0CAEuU7BlaJJBv7MBSDw4RswLchFK7YBO1bAZjbmDFj8tn0r736asALZSW4rGxJNu3abMU7Onbs2PI4XwkoR6Gq//TTT89H+okTzi9r/sBx+IixSldccUXAw9LPmqx1/xMdo2djBi/HnpYNnzqP5owPDdrzgU49N155CWH3NiTbiPzqa6+6bUtOxlC3+VIebWuzZFAejzEfP/zRDwNsyztX4VzqLXwBDphDYYfKytPZEp5nQzG+6XsLDK8yBjzPxnxzAWY244MJRQpe+20jrDze25SsTCkPJlddfVXesP6Tn/4kbHos71xtzFWP+uG4ZIOtd5JQHM/Ubd7waHNrE39nUKDghxNc8AYyyylgxlUSXuEUMLLKxmf0XUu3foMBuYYX2UwON/EkpxWVeso10/+VV+ZTX5Qtz8vVfPheBtla+14b5lB/Sl5XG1TBX9/guPHYUOqEoFq6kbdeEvyDH/ZV6BOahd/g5qhqPMRzyXiFNII/mkb7xug5WDu97pFxjwT89B6P9l5Zye8yv3gS/lILV3kkNAbPC87iV/gPuJpb8yKfpH9g7Z1+wQ/zStbAfXnqOcFTG/rRK7rFY/ELfTZOMAZP71zB1HPvx40bF/YB2pcGv+iD4IruixxwDLeDJ8hH8thKp3qKLFCPVFveYTVgqB39MZd42aRJk2TNyTxqW1/pg3AG7uSXdfpnljcYbvjrDSHeH9EhWCEehaBMMAIeO/a68L0D8WmICyMmtCCPzXI8HRttvFGoywYXCFzmG9JAJPeukIMQcyrSyJEj85GqnkEWhLpY38UCw6QUYPoQTww1zylVkwAAEABJREFU4r/55pvzjn1CAGMdfdZZ4UvO6m6kmQMChA/hTICUGMnakYkRtqIAL+GqPQKYug+RCZO46+67A8706Nkzh6PVekYwL+FBmBMPnU35j1QMs9SfUsqbr9WvTjhahGDJA++FAhD2cJunVX02pGKoJV9nuRqDzWbGy2OMlmthRqGilIo5RX9+5zIXXZS//gxW6J1hb0Pc5Ncmv2fo6lInwS2cyalJKb3rTRIbS/jYP6EtQk8FEp7knVPLLFlTQCgbnhM0cEW+zpTgiJPnwEGsOnhSBssYUqpwsFu3fAIcQw0PVIZRx0kCxylh4GC+wD+lVIrnY4nB7FPzzBM33XhTOOWq7WX1w3zAWfH2Tr5zYlytwVJWMVzNBTijwxtvvDGkqoq6/gfPKH7o1uojGn7woQfb+kyRdGIf+scPKDKUpZIBLIyZTBpbORQomWK8zRmlqeRzxXvg5Le++c2geHlWm9CJE/tsvubYoOx6rw/gblM0PueZBK/xFXnB/LjjjwtyTh7Gea2yJX89JDTohLtRo0YFYxRMOV3wCjTNKKbUl74ag/mhC4gEMD93//Of+aOQ4G6fk9Bl/EgYnvdopZSnxHJauu/WvVuAf+38gSEnkcMV8Bu8SRm6DGXUXNIv8B11SI61pSTrj7Cb7558cpgj9aKlMm/y1mPSVwo+mOIJ+G1K7/IEtOwZWMA5ulVKKeTn6DVGMowTDF6KBmHkqhMdkG1wncFsPqqlt3z0qnkA7wIThgl+JbqDIwR/gb9gLzSXjP75GWfkdr1z6ACjDH+z18KcnHveedlZXeqst+ssbzCs//n1Y/z4cfH000/lDXVbDR0a9953XxY8mK7NMtOqZaPVP/e5sPll2LBh+UMeiImS4NgtStgWm28R3z/1+/kkB8hVJhoSYsrqYlzwBENYSI6hQFrvMAWnf2y7zbZhYw6jQF7xyI5atcnpz5f/OSAwL5uNYoTfu2RRWmxcOzME4EZKKYSVMFCllFpn2Xw7ncjRbBiV0zFs7GJoUg5sELX6lI2K7t3zSTqMzQIPghe+jxgxIuAV3Lv3nnvK6xyzbCOWUxsIPidLwPm2DNUPHhgMjkDXB23ZPErIw+MqS6f6R4g88fgT+ZS05t7N+eNcxlYGQUkiQGzQ3GmnncJGQ0YTg80+ATDgnaMUEMZgXMq62mdiniho9j7UnmrmPWeFjXT2eAzbflg+itVzifJ35VVXxU477xy77bZb9FlkkcBP8Adw1zf5OlOikDKMHDRB+adMGnsZg/04O37lK5nXOqKQAwYOMx7A3h4NDhf0QREQy97c3FyK52OFDxpxUHzly1/Oh0tQnsxRyaBNNGTuKLlOVLJ5trwHW/Nl46n6HaO64IIL5g8nOj64tq5Spp6u8Pn5F14IJ5Q5US1SvMfQ4elHv2C+zpAhYaxgWsZgtQXMxFJTWhlXYrjBgMwq+VyvvuaarOiiD/ftE0XUvBVZ5T2ewwDmtZ1/gQWyLPVcQjurrbZaPv2H3H3l5VeyEm5DP36EzuSrp4Rfg6nNs/oF/vB74002DvzC4Q833HBDdvR5D6ds8G5pacmwN64Jjz4alFK83Fw4xMKJhS1VnhUGrxDoHGyU945+4bCTNVZfIx8LrYx3kvooo+YYrsPXt6sXm262WT4xzMZbedRRPc7/9MkJVU5nczLV65MnB8OGHGAkG2POWKd/8AmOXLyDYwUOFZjgk3AJLJuauuRTiMjPpqam1uN7H5uQeQY4cUjg1xR5h1eYkyefejLuf+CBwK/IOEYDuiI/OTEYYQUsVjkcUIFXOzXs0ssuy99DQjtg60SyP19+eaAvdMFA69a1azYQGGpf3P6LYXW0ts5Sd71cZ3mDgYCYOu2tuP76GyI1pXwU38SK4V577bX5fG473BGYsADHxZn0lFI+scHEb7jRhpFSxZWrGSXYCCCegeo2/yOMKBO77LpLRhSIB5l4HigK06ZNyx/+0Aak6dKlSz5+MKUUFJDrr78+eCvuufeeeHHii/nDazwGGBQkz400/sw0EMCoCR3C0fGNVpZqPTzmnEeW5wJjIxgYCRQcTBKzUceYsWPzNz0wJmUAyPsRB43I3ltLzwQK5mr1DC7DK/kYIAQ6xui+NmmTgdzc3JwZnXfwnWKhT+47U2KAoz0GAJigb57CMgaC1VyYB948cDJOCiv4UbAICkdMMtgoRKVsuZofy9KOLuYR581SDwXsueefD4KHJ1b7hFLtfA3o3z/+Xq0sWs1k3FG4GTR4g1CN0kZnueJ3HB68qcbMiw/Gtf03H+BN0aT4UpLAimEKvry6lNk//PGPAe4UtlKehxaP5RE/59xzY9XPfjavBE147LFQxnyjJx5Aii5FqZQtV84gq3wUPo4azymt5to79/WaKEjdqxUauEHu5LPdX32trbu8/nDJ+B3XSb5QnkoGKzdgSPFyShFlzBGTYNz+1CNKlTAPxod5hbfmatz48fnDoWSn1QwKsnfagN9WLihVPnxqLjyX8BAOCnyIfPSMU40zhLwrocOe10uySibiAAyMBRzgWPdu3XMX8QRj99wDfBPOdq8cOlYA3Fu9ZASry/xJeLDx3nH7HVk/ULfycF8oi/njiPxjRQOUWDxpfGV4kAeUfnVToLU791xzxTprr53DxjgtwZeyqj7JvKIz9fCQm3v9pp/wjONf8tVjAlvGAp7ByWrV3YqPMdb2F3//1a/OD/oZvs1olXyLB5ymVnoYfiN0C+w5cNVxzz/viS5NTfn4eQ4xsLE6iUbAetK//tXWDN5MB/TAigFZjG+BofkGz5dfeSXri+aBfEeP8ku+k5Uq607b7usxzfIGA2TpXSk/rHjn3y615FI5LIMS4DjEMmmOyRo6dGiwulNK8cjDj+Sz2zHIkgfSUgwQdXlGkRtSeXL+ct1fsleXcgV5MOnCBBgqTV1apwIBqIfhQMFADITfS/96KRswEBqTgYTyNlXIXNpqXDs/BHgoKKYEpjPGCQYCqIwMk6IIOJ0F0ycQvKdEppSCF9aS94knnBAULEoZfCrlMUFCHB5Ztq64V96r8K2jjgqeKfiG8fIwFuZXyroS3vAW7rmXMFDPa2nB886QCA9CxFL1D77/g+wx5RktfffRQ7CWx3F64EkQMBjQKD4BlsbOyGKggXEpD1YEAJqlyIKvpelvfutbIRzH3OEtzu3m+bYMTvAoj08w0Bgwv73wt9VUpWzspZSyU6GWz8jfWRKFCG4LycR/CW54XPoPloS2FS78DYzAmsHLqcKQpRj45gcYWYkFZ+XRB6OC4vn1I44IdV9y6SWBno455pi814bgpzQzFtSnXEnwmoLE6LbaVp7DEwotBaA8q8crOoRHFH+hW8aHPktf33r77fwBRt8kobRY4RIKUd4zZtVhrEJr4CYHwWrVCjsjr3aemueeO8wL/mKeXM/4+c8DX0EX6jBn5iOlVqeaMI6nn3oqhxpZ4WE8eK99c6h9ihXDXb/1Tz14HTqQr56SPsLBMoaUUqU/dIloHW5eWTCulN55EJGjF+wjo/jDyTnmmCOvtJgrv+kZ3oG/ejkZUmotn1LKq6EtLS1xdIXP1429LvAGxsNRFU/Ba/QppRTarZrLfWCUM7roFGApX3kP5ynUPjjJQLTqRzFGp67KqqdeE6cvOOIncI+x3H5/wZixY6Jv39bv1zz/wvOBj5s3dILf3/PPf4bTweC7d+Mro5eOZezTpk5r+3gh/Acv8wLnrRAUuMBTNOBevh6VUdhzttlyCJJn3nVpasp1mWd1eF6SeVZHPfOYVi219HgWvJo4iEHQ+2gPRYD1SCmzlAU5KqMvFu7TJ59hT3lAaK+/8XpYqiXgETdL8ayzzgpEV6swEOqQkgImDpMVD8y53op5+91rzl5ZEYC46lEfBRAjX3OttYLSwNAQnnL9DTfEYn37RrfurR4MDJYAhGTKqq+ROi8EGIdXXHlF/roybyb8xGjMMSZk9YGnlDGLwWSm1a1bTJ02NQ8aPlpGJnzgIXymRMETeMv7QsES5saL1LNHj9h5p53ikIMPDh4u9RMeK33mMxknVSo0ppR33z7pH6WOUtz+3Yy4/zhtojGrh5R05/yDMUEC3uDWd7HF8rdNzAP4UZCKEoSGeRZ5UCe/Pjl7AsFKOeXBxe+777orwFMdhDBl9tBDDsnhR1YgtYne1ZdSygIePXvOczikcji07NwShA8HhHz4CMXg44y1HvJ2rXBVKAoYU8LBCEzhKhzTR558+fBM92BmzG+9/VYYt9Agio063IOD8hKjjeKALsCW8dF3sb6xz/DhOXyDN1f9DDfGufrNq/kyd34zANGGFQjvJfhtPngO3ddrAk+4LHR2hy99KVJK+eNTeAn4kG3wsGfPHpVi2zXAlZJSxuMd2Ljn9WY8rLzyZ2KhBRfMKzSUHLAqeeSTwE09PigGt8lG8+adNlwlhsdalbcbrNWhr+QWI9xcMpyt6H166aVlD/1W3js0kh/W8R9jnnvu5nj8scczP7Aa/Kl5PhWTJ78e4Ga8lHs89uCK51LiDYfTEA8HXzqDkCQGMx5vlUs5zynw+A/+3mvOOeONN9+IQQMHxR577BHqg/PqAzPJb/PI4YGXoCn0pj5GMbh7zviAH4xIITRwXXlw15Z66jHBO46uiy6+KOMz+ZVSCvSPR+C/cO2+e+/LzjQ42rVL17A6ttpqq2X8kmfK1Cn5gIQFF1ooRowYkb9Z0rdfvxxJkppSNujMlXBUxsQ/7vxHNtwYt/gW/kBHI3tze/fdF8stu1wMHDAgOCDMvagVTjgGW1T/gW91ed8//Ox9D+vkwSxvMCBwS1EmG7EhUERFMItbTinF1ClTws543lvem5LH0iIly3LellttFcdXXl3LTMIFyvxacp9WKXOjR48Oy7o8LJDce1dIw2DxQTeeYUu1EM5yMMK2Cefwr341Mx/xdcISWNTKEpgsav2itPDGqLeROi8ExLxe9LuLsjLp5A0ClCEplpq3AwPHoDD1lFLed0C5YUS8OeXNYNDa1GZZGr4RALy1NrXdc++9eZNcee7roeJTKb3KYWSEOCE9z6c+lZWNadVSrVhO4TKYIsjCWc/9lp577tkcKocZuu9MCcMnKHlcxc4T1AsvvFBY0r/lllvz10MJajGoNq8x3vGF5557Lp9kRvknqIfvPTwIdl5rQstmunHjxmXl/6WXX46FK0FEWBFk4ATeeMxWW26ZYSf85dRTTw2eQyE7NlDzqKJxRp6wEEqbOaNgqVvIR2eCtb7O1atXbLnFFsFIs8pAWbFy89vfXhD4H772+BNPBGWI8qoMJRfPffihh4Oy5DkFCCwo8D6UZD8Zhw0+TlHAh80VxZliIKQIX2dAm0/1FUWI8gTGwjvgNSNDm2CvfYkRod1aI8Lzekvwa3zlHeW42mXXXfPHH1dd9bNx+uk/C4bWCssvH+TdQQcdnJVMMISHZRxkIGP1xUkv5hh84XJ4CUcGGgE7uL41AAMAABAASURBVE0JKmXwA/OmbTQAt+G4e3m8A1e/96wUW6G9X/jiF7NSpm7KMzmG9wjX1fdtt9kme8i32WabbCQaU73iexm/K2Vvo402CgdPwO9nnn0mtt5q67jssksDDwdbHmz7HJztL54evvZu7h0P3P9A5rmUeCto4uSFZK2zzjohRA4Ph9+cRUceeWTmTUPWHZKVX/MG7lbswFkqMCcrKL/q23OvvYIcYSwL+xs1alRwjt5w/fVBTtBp9t577wBv/Acvoiirrx4THIPPf73hrwGe5CV+YC6spqBb8pLRZPXAGDgqjPOggw7KUR94w0orfSY8/9Uvf5k/xjh27NjYdZdd8p4Hck8ded/IGmvkvSfkId7CQDcv6MR+ICsbVirAcpNNN4mVVlopGzItLS15RZl+h/foh4Q2XCXGCFmkHff1mJrqsVMd2ScIR9nGTHmf3CN44QKI0+QS1kJDHLlK0FH6Bw4cmE+hgSyefe3ww+PSSy4JBkVt/ykaJ554UlYm1LHddttlpkDwMAYo/9r0VVPGBSQnOCmBGM65Z58dB40YkRU93oWRI0fGMpX3hefnRz/8YWDkljfFHtpUWdt243fngwCD4fTTT8/eUEICw8HQKECUHXhDmMAbo6OEMlqffOLJeO7Z52Lo0KH5SD5KLKHVr/KSWJnCqAhx3hh4SDmVGAvqKQnTJNgGDx6cH8HNddddN1oqhkdZ81B/bEalrBFK9913f/Sr2tE37ztTQlM8foceemigP9f5518gCw3jBDPvKTlWb2yyRfuMfLAkmIwXLNBhc3NzgINlfWUpmeYCDFNKsr4nqQe9y4PnUCAocO4JfwqdfjmZipDSDg85oc9YeU9lneCGE4SBQEHHVyn5/fv3i8022zwLb/i2wfrrB/wCO0MCUw4UYS7KUwp4RClNeC/lnqFHUIMZvKYMoCP1KKOekhgQFFQ81DNKnjCn4hXn2aVcFYOBwkDBo4i0r0v5ekqMIB5SBic+IdSuZ8/ZYvvthwVc4qVnbIELvJKX06yMAc7jM/fec2+suuqqgVfst//+lcFxelhxxx/gdv/+/XMReTklbKZN6f34DYbCeDfZZJMwt7lQ9WfZZZbJm0498xVt8wW3KWH69bWvfS0bOAx6yisvsParonX3b/755w/8gUFjPBR8eoEx/fL8X8aCCy2YlXo83Hguu+yycBoUfeLYY48NMDc24cz4KYXdCXZkPd4DLsLj4CRc1Zb5xTfwajKgPVA4f5xwpW89e/aMA6o5/OFppwWDDR9h2KEXczlkyJBwmAW442HoipHBI85gYYi0r79e7lNK2Umm7xR2NA/f9HtUZQzBU3ocWjDm9v3Gf8G6b7WSTBaef/75eaXGyUnuwQ8/F8IFzuBNbxO+StczH2QrI06bTrvEq8Fee+buxBNPzBvO6Zh0zdIHPA288SGGB3m9/AorhHpKnnq7/u8GQ72N6L/ojwmjBGBuimOCFCAIggFQ3jFPTJFljmnKJ0EYz9b7/OezNepZbYI0iM8ziOA+pZTDHCCz8t5pC9JZKiv5PV9h8OBA0JCW8YIpYQA+rKPPjAT9kiC3Mo3UeSFAIcGoKKZwxUjgJ6FKsMMB817wxns4wSvBmwKPeFIpPxRW7+GrMs1zz509HhQm+AJ3mpubZWlLylNYi7KWUgp4BVf1TUZt8zrJS5DzyGqPMuJ9Z0uEBiEPHsaED4B3797N2bhH/xR+MDa23r1759OUeEYpk54pZ77MEfo0h+AEZubBHMrXPqWUAr2rvwhmcGQQ6od6GW94gHnkkeLFYiSap/b1dYZ74zJWOA42ESkoUmU8xolXgl1U/6WUssI12+yz5+M78efPrbZafgZ/U0ph1UeZlFrhCV5WZMGvquI9/wjxfv365fh7L7SDPvDYlFrLm5OUWhVgHmB9ZujIX+8JrnE8oHEGBBkGPq2wjhxmQVmB7/hJ7XjAlgwyZh5/cHGyGqUWnOSH24U/eKZebdbWU36n1Mo/zGlKrfD0Do7jW/qmTXWiHanIQfMB33mH9dX8KltvCW6AAVjrmzHgFfAbHnlmLHhKz0p5R8/GY37oDvDRfCyy6KLh+xRgQ9+Aw+CaUgo8yFyoy7O2+a2MQc/aJ33Aj/TNO+2uWtEMPk2B9kyf9Qn/06dSJ9o0L5RkyrD25K/XlFIr/YO3fXto3lyQg/AUzuItnrUfAziRbeDjnd9gVHDTXIjgsLJG1sFVxh1HnrLw37zAb+XhKPoBezBMqZWf4O82l8tTErjKp79WMDiB9tpzz7zHoeSpt2vDYKi3GWn0pwGBjwkBTFEoDGb5MYu+L/vHfYDRWjUjADHIj1u+M+ZPKeUja3m0CKOOHENKKe814d0C+45se0a2ReE6rFoFouR0dD8YMxQnSltHt93R7VFeKEyUJApRR7ffvj08hSIrdKmjaa19X6bnPaPBigRHwfRs56PWDdZWRDiXPmqZmTEfgwD+ifaYnvyWE8pqT73M/4fN5SxvMPAQijcTXiAOTUytZUEWpaX/DwKcMASbk1zbv/dM7B8PDe/IB73/sLLt837QvbI8LmLZvddXsW+OXhU77Zl2beb08RHxufrkuXhEY1TePgnPGqljIWAubDYzD44YNJ+emSeb/ewvMKe8e3ARDpovsa9i182t+Ta/ljF5ucVb+k3oGI36nnr66Xhh4sS8qVFcpHokeKl99cgryc/D4RxqG+6177m+wSub9rXNw9K+T/IKCcFM1aNu/ZWPx0S65ZZbciy/OqdnQnfa1Ya+GJNTcoQ0lPGiGxsRwaI8k19SRvyw/kvmxHP1CEkxJ+6NaeKLL+ZTyyg0eAX+oe3aOsHv4UceCXBTriTtmE8ns2mntow83oOjEAVePjD2XD021SnDW5ZSynCFM+KQ8TL5ahM6d3QmPNEf43dCkLpq802P38YAzqVu/Amc7JuBr57DK/gFvqVPnjnpBNxLHrCF3zx+xqEO4yj1yCeZG/B5OxxV4UlrAmP8zz4vdbn3Rn60iC7A3TN7eNBiwRu4DcfNtbnQL3VIcAQ92lNSyqujoxJYGVctHMBZ36ZOnZq74d745IN34JdfvPPHPJkD8Dcev8GljMdv81b41TvF8kUeK4xjxowJ9Re45pc1f7ThvUfK6BMYOzoUTD03BnMK5wutpZTyaYScIvphXJLf5knYzIe1qc7OlOwbg9/GZ48UOOm/cdoL4d4c4af2kNx0882Bts0LHu+9/J9EoihbiWBAfhL1Ta86jBnPputkun/nIJnSHlx3EAL8feXVV/JjuIUOwNlqLb4Jh8hUshS81ZszV38YT1Yy8Qm4rk4rQXAVzlZZ3vMPz8WPrfgX3NYmWYrPlWcKqcueLVcr+WhC37yrxzTLGwwIz2YZm+bEr/EkiYezAU6crUkzwQQtJuceYooNJVDcm2zv5ZPEA6oPcUNE7wpiYZrKQlZlMWj11iKoMsqWZ8pqAyLqF08EZFS+bIwVt8sjgHE4jk1cqfG0tLTkzdbqvOii3wWCEOdH8Sj1q6eROgYCcEd8uqNNxToeNfKooFTZSCiGXTyl+Ed4In7VBkD4Kf4YrlJWxG1jKmJRxReLhx0xYkTAR4yJ8N53n33ixr/9LZ/ugJk6du6Ybx+TT/YSgwnvovrv7YrBYmLiye2HEb/6k5/+pDI2Xgh4Js5WPK6YTvWLx9Qnm8bE0FNEqmryP4qzOFu4JzbX8aHoQb2EnLZyxk/4jzEz+sWew33VU0RsJBaDLR6aYmFjuDz2+3iGdmr7ROmzf8lcoFECQd3Gof/GQvEWA37uOWfngwgIHPOJpqw4/OaC3+TNmgSLeNeDDzoon8ShT5L2KMNge+GFF+YNdJRY70pitO1/wAE5fty8iVV+4skn8r4KvAn8zzv/vNy+edHfU089Nc8XBbLUQwCK54Uvhx52WNi0jY+AEaNJX0reT/KKX1H68B5xu+qG42Kz7VkAF/tzKH1owDHC4o3F8+JTFFbz5jecwkvlk998oBM4jD7grefaIOi1CUZvTXvLo5zMGxxERxdddFEFp4Pj+htuyPRiZU5+9EPx0p759H0B+ZXLlbzzRx7zPHLkyHwiHhyhsMiPNt/JNt0vYAOf7UWAH5QejaJH9Cpmm1whR/ATY4HTcB/vkFeCD04IJA8oqeQfnHKsqVh7MD3k0ENCHebA3g/1KitRgoYPHx5kDbiAr755J/mNrpTD8zxDG3jE6NGjo/QJ3MXmm1M8BjxrcRk/NLdoTxkHMQi3sYEYbU8vXNbfjkzGjK/bsE9WgB8l8rcX/DbTOzqyWdkcffPIIzOPoKc49Q7ddGRf66EtfAbe4DPwg2FQ+gUn8JEjjjgi4JNwHzQKX3bfbfe8CR3s1AF/6U/4kvwMAuXV5Xrdddflgxo4D+Ac+QZXHQTAGJZPwovwN/tc8Tu813v8Cg3BbW2Sv3Q19OKEQkaN8vCcPHdin/v3phl/N8sbDASQ+DabiAguihClGgPDbCXneBO2lCdESVmnRPAAQhCCHzOESJR6AlM5CcJi0hARgowZMyZvMKLQQG6IrG6Ch2CDEpgGJcIz9TNACIcxY8fmjWCYOEYi2YhpQxkkJCyUU69NUgSH+DoKgn7deeddIXSk1oDRXiN1HARenDQpBg4alAWlJcgrLr8iHnv88Vhu+eXzs+2+sF38vfLI86hR3uGlOFMx9vCUokc5EPtI8DprngDl/YRTDFEChZCGTzxEYiqPO/a4vOlxrrnnCrihfqPGDDFR8bQnffe7QYG64Ya/xuV/vjx/6IfyZCOiOFf7FiinlCuxuZ4L11CPpD+SWFLM26Y6MZ+WWdEUvJbvk04Eq81mFDcKkPp5oDFlCrf20Sxj+7XJkwNdMAzOHH1mgKX8EqODF9vys02w4oiNh7dIjC9F6Rdnnhl4ANpWBv/whVYCwUklf77sz/lUFzRnzJMnv5ZXeeSVwFtfKDuj3tmUh849L+/Nx2dWWil/O4ACZ87HPTIubF5H50JG7qpomXBxVLPwJMoa/MB71CMxGOAVwbbJJhuH8ZsP8dVjKj5kPPJ90gnMzAdjCg6q32qKKyHqVDkxv8YFZxmZjLt55p03nzxFQRJDbC4os3/60yX5ZBfl8bHrK2Wf4YdfE7SU3cnVvOKz8L7AUn7JXFGGh1dGNIE9cNCAuP322zIvFeoEH9AY+ICJ/sNxc375FZe/Z/7Uz+MoZIeygJ/qK9zmgdReRyTjZaRSdoxX0i4FxKoaPPBMv8aPH5/5vrAeShHalVeCa5Qh8d7GximB5tEMOaKexRZdLPMmBgOZN+GxxxTNyRzDRzDEo35zwQVZsc0vqz/aB9c777wzz231KMAXbjKahTOiO3zLPgv47eCG2vzKoHEyeZNNNomv7LhjuNojhLf9+c9/DkqZfJ09mTO8/Pbbb88GPvrB0+Cwd2gGz/V7yLrrZl520oknxRKLLxEMDXk7Oww+Tv/pVVZCGMTkDXwt5elbDAEbjb0fPHjFzJupoV20AAAQAElEQVThHr3IniTGLrlGbyL78HEbxvHuUhd9Cf8iN+lc+JPDbOC81cW/3XhjaTIfPcyoI7sZxRwOjOoHH3oo0A9H1V133x341jXXXhtkddHnVDJkyJBAXw8+8IDbukuzvMGAOAkTCAJphGVAGEv+BIPJx4QtSfsiLi+YWSTwICplnnIA6RgOPGjOEO/StWv4EiljwAY79TIoCCh1YQQsUUipD5QSyoe6KRPCK0aOGhmEPYbomZMlKJDqg7jyY5Q2jImvxXCFJ6jTO8uKGHZm0I88komFsqDtlN7dgKbNRvrfIfBRalhi8cVj//32yx/e4iVbZNFFYulPfzq++IUvBCXutB+cFvPPN19QluAJPHisEtBOz6HkE9iMBQo85kPRp4BSlimMyhRFpvSHYPVhwDN/cWZss/U2WXmAc967Unp4qHr26BGYofYpEvCGhwTTnTLlzejatUveMAnHxDdTUhkk6pEIdQoHzyTDQl/lo4xhkJQx+T7pZMw8zRg6Qap+G/col5QfHiW04fmUN9/MBw74/dCDD73HYOBVYnTzVlHmCRawBSOb4XiXOBR23PErFSy6ZUUS3Ts9h2PAfK65xhp509pGG28c5ielJk21JXURVhQkp/0wFgYPHhwptdJjSil/cI+HkXJPmXOOOxgyYgguPMbmOnMO5vgPPvP665PzsaOlMbG3X/vqV3M//3n3P/MxlngC/Bn/6Ph49bVXS9ZP9Coel2Hg5KJSMcUSLDlWCFF4Ab84QhgXEvymCIP7UkstlefJxuX99ts3h3+llCIrRNWqmL0MeB44qAPvVo63UVhHadfVvDEwNqnmhANm/Ljx0bu5d95gSlHG7xl7+oPv64dVHPx8g/U3aJsbdVEQGKMEvflDC8ZrTq+59hpZOiSB346V4syw0V/yQMOMdYo4/uAe/wd38uX4E44P8gtdeCcxJtAl+gADGzEpOxRTsEdbHBtgBM9cF1xgAUVzssqID1B68K8VV1ghH/WcX1Z/yC2ro5SxQpsMFuEXVlN5YsFOorwxFHhivSd/qyryP6siDBo09p1vfztc4YI+ogNzlzPOBH/oFhwunJLoHRzwDUMzj2Q4uHbr3j3TiFOYHOFpZZKTRL5ZJVnxxUM5c/F5OlkZO9xHn+QRYwoOoVX0cOddd4aVS/oU+UonKjBmIJRn6sKr6YhwDc7BY3yf4YZuHq0Mcs/kJT/QDBwnV+lh+oAeJXxr9tlmi2efey6WX265/JFDPKzQr7l3fLa51Cd11lN6rzSrp551UF8gCQSyxAepKFcYpKvJhhTbbLNtnmDIAJkwTQzOSSWYJCGEaVGeeLsgz5QpUyov7Z+zsKb0Yco3/PWv2ZPMI2XHPERxlJb3FD9MwLDVQ4Ej+HjNeN8gKKWFkFS/JG9Kqe20j5RSpKam+Px662XLlZD805/+lN9ThghHgqaUjcZ/HQ6Bwvx5JzC44487PjAxSg184nGjADFUdY4HhfJEqcRA4BmmCG8xFwr6yJEjg8dTPoYGJtZ+noXUUA54czE9Stu+++8fJ5x4YsBNz4Q3wF9H+1IsKU9CEyh+l1We85deejnn5UmljKIDfSyJB5xxzfPpmGBX9Rqfvk8vYUbJQY/oBm5LN950Y4YrOgI7YVdDhw7NCjUPN7oCc3lL/3mNGPXeoTVGAHiDqbwUs6WWXDJmn32OTNfKgZPxUZx4Oy+/4ooMo359+waFX/2SvBI4EHIcB+ZimWWXDTDnmRWGRFGlfKWUsjARNrXvPq0Ksz4QWtrhmX/5lVcCHjAmGYm/+c0F2XOlHQn/8F7Iirmn4HoOb5pSU/DYuv+kk3YZr+aj1A3HwIOSqP+cIIwDnlNGHe/g6af/LIcJpZSywZxSyt8MIGhLPWCZUsXnquQZx8z9lTfurLPPzufSp5SCcEc/aGzfyjj/zW9+kxUrCgPcbu7dHPDTXICPevSV0Cao9WmHHXbIpzDx1pMD8kiUX6u6DGl06JpS6yk2jjZWp3zTO5EVHEVwAkxKewxLCku5h5vHHntsDik6/WenhxUb+FbeM+TMF9zm6TcnLS0tQSnFn+TTFtlIllihaW5u9jgnZeER3kFWgjdl/oADD4zjK96C5vv16xfy5QLVH/yNQ8LKGGObM0EdxqJdqwfmgVytsud/8B7c0eawYcOCEsjwMT48tTZvLtCJ/8BD+gCvOLjST8AG/uJHS1UOJnK+dt7xoU485P+664wCupRV9tlmny1OP+P0Nt6sUvoamhXKdu2YazOvxQNEdowePbpy/HQNeL7NNttkY3q33XYLzgc4r7wEN9HF7LPP7jbwjJRS228yLt9Uf8xJeW9OzOWUqVOjS9O7qrY8npMxRZ+riuZ/5DZ5wzimQ+aHdfTn3VHUUac6sisYvJCC8849Nwgx3g1M16RiRJio7x04xnTRRRbJyOidyYSskILiRGFB5OtvsEFUmap/bwdhhnlDjDXWXDMr8pNfey17NQklQotXhXCzvP7SSy+1DZ1x8sbrbwQmDHlqhZb2ZcREIDYLWFmCcvFBg2LAwIHBy8TrShBTEB55+OH4zMqfUSz3TfvKSLV15wyNP9MNAgSbZXcKPKaFYRCYFPh55pknhw2l1Kr0ULLkW2211aJLly7Z04mhwFkMx4a3vffeOyirlMaUWpmYzhcc8dv88sLwPmojqmw9Z+sZ8/TuHXNUTPDJp54Kggke8VTrE9ziDZEYq4wHbWKecNOXiylZ2qEUwCeeV8quspQpjFMZKaWUxxDT6T/9kFQPPr7sOaRa3qWcOtKOx0gf0Zux8nhSZNA4oQJGYK2vlKf55p0370UoYyx1q7/2t7mj1DP+CaIHHnwwar2dJa8rWgMr9E4BYnSJq733vnsDX7DpUdscCAQcb6v54GBg8JxzzjlhLhiHBJjVEvNJccSzeGUnTnwxGyx406RJk8Iqx3333RcU9aLogY9x9Ojew2W6JuPWAMVuqWrVQH/hlGc9evbMqx7GZIy+wGqO4HopJ5/fkrkxH65gBJ7PV546K2J9+iwcPPxgxKAFL7AEU+0I8dhp552zAXLE146ojL7Z81GV8AKdMajw8XsrWOHllAwOF7CjpFFOKQbmBO9HD+bcb30D0+7dumdlQp87Kmm7ti33JXkORlZe4Lk5YHwZh3cSfuIqgZF5MHbhS+iBkkomWnnEr8yV8mjGmPEMq3GUHEqbtnNbzc0xZ8Vb8AB1S94pg0bUg29xRqjPiobYbbJKqAgcmDhxYl4V1xY6QzuO1jWG7pV3XX1wwbW2HW115mQ8Pha740475Q/vgfvUadNCaAuehYamvfVWPvDA/JL75gddFaW2M4//4/TdV+PpV2Cy9FJLxysvv5JD3+BMVDKH46I1DYhF+iwSE1+Y2LanEw336dMnr1rC+28ddVTssccewYjl0IGD+uKaUsr7AeEZHGbw4glgL0pgcrW6iyfjwZMqvkvOc+b16NkjllxiibyPTZ88h+/zzPOpqntJ9WG+JTeu6sfnUmp973m9pFneYDARkEAYUS3zTCllBQcSmDxM0PJ/UYgoGFYHxMf5jaFZLqSARfVft65dAzNE0DyK/7z77hyqgKAh25gxY4LHxhK35SvCXD+qojleF5OG6DyOlibFTUOmlNJ7hJJYbEvFYu8gGgVJXCurWRmC0LnW+rj0p5cO/0F0YQ0YPe8Tb6XnjTT9IUDh4JU0l8IaTj/99OzpNcfm3AZMiotVAnGPlBleNz3DuDA4XkGMijI4bvz4oMDzIqtbPimld5mNOgj+FVdaKTOpnj16xhabb5GVSAbHbbfeGoxlOG5DKU8eIwVj41F0TzmigD33/PMZ/yhp2qHgwT/KBfw76bsnhQ24YusptmiKcueKQSszvVJKrWMGJ/sPeFJPP+OMPDara/pqBQFdcARsudVWmVn/6le/DEa5jcUjq9WaH5x2Wtx2++0hNptig+Yx+9LvlFrbca9OSqrQCnNgdU8Z71JKGd5+U+Ap/5an9YUBd+aZv8gf2Vtj9TXyBx+1bUUHvxD3DV6840Kk8CHtnPy978WvK4855YDRIWlb6CK8WXLJJfJ4xZ/zwppPSpVxo3l9wX9cefxdp2dKKeXqGW8MJaED8EVY1HrrrhsEM2fJ6NGjw5n0/SpvdEop00QuWP1JKWU4ohk4yDgCl2OPOzavHDCWv3HkN7KTxCZvjht8UAgXQ2ndynA0/gfuvz8rWeAFX6004ZXad+8s/FVWXjmsFAgN1Cd0wCgAR3iMjmwoFtpDyaVYg++ECY8GxSGlVPW4Y/+l9P42U2p9hobxFv0FC7LGilvpITyC2/966V9h/Ixd9Au+FHenfFldQNtWO8GOkeW3lQKODngGP8FRW/YykC1WvWpxLKWUecdy1aoauYge8D9Klnm3OnnsccflvSVwGW6QscLy9JGME9ImVAwNwYXnnns275kgP2Mm+S+lFAyEnj165A/CGeekF18MPGPZ5ZYLzsvuXbvGFZdfnjfe21COp+Ed+OxMAoaPNAz0x9CFs/CEg9SKDLwBP8o/2ifHslxYbdWQH6/Gi6xk+a7CrbfdFhw/lPynn3kmH11dYNn7U73zSgRl31zU8h+64cqfWTmuvOLKuOLKK7NDhzHr4BD0sObqa+a66H1w1woZfB/Qf0Db+FJqpVUP6GnPPf9c9OvfL/M2z+opzfIGA2/SiBEjYp7Ku1s7MZieUCCrD0KU5p1vviCAxHdiuryJGC+m6jfm1tLSEu55cr/wxS/GRhtumDe68LYyHiy18qBojyBy9UEcQt/vwlwZDgwRm2YoXeJyIZn+ybN35VUmcN3zlIplFQ7CwyOf9hkS+omZiKUjHPUR4lrqJFj1gWKljLpmZJpV2uYNwax4L8Gf4IMDPMreCUs69NBDs/dz4YUWCpt24U+BDyWWx5AAPeKII+LUU04JDM882jQqnzkW7gKv3FM8xRkPWWcdt+9JKaVQlsI5dOjQ7NFacsklg7HKmOQV5qGHM+oVakMwFZzBMOWxEibfCcefkJkm2oGXFBbGtDqVf0/jn+BNSikr3VbtUko55AQc5+rVK4wL/vMiCX9h/IDP1tV4GUnLLrtcDl/aa8+9Aq2Du6sVAHAgOChHukvoDKkUUIKKYDAum9koPJa1zWMJvyBYxMjy7IKTj/2YS3Daa++9Yu65m2PYsGFhv0KBTUopBg8enDczCtmAD2LL7cmAN4Oq1cN11lorKGOUKjyCp9Zco39t4Q2MFmUYp2gdD7B0T/GDP/KUNo1reiTCWoiduo2dQQRPeLCNjVEMvzk07D+xIoo/mieCnPBUVl/xPF5sq1fmDl9cYfkV8kkn5hOv67tY37wZ1nt5U2oVxOZYuBmleUg1dwwT+Au2lGjtaZuhAUaHHX5YVv6Hbj00r7zpE1hSFnbcacfshaRoGw965FGEH37rb0cm/TK/BedSSoEe4ZX5NU44CKfQuX1znA6lj2DX3Nwcjzz8SKZ9NO8ZXN5n330yzBy+mAAAEABJREFULQvtEqoBh9RDBi1bKf3aBDNwNdfoxVyRX6X+cpWvpaUlG37KwlvtrLjSikH2+YYM/GZMwGV0CpfNBxok08yVlT+yFG8xr7feelsrr1x44dJUp74aE34FN8ERf7HCQBHGczbeaKOsSJL7+DBYoQUGGhh36sH/F53fYP318+lxcOmIrx8R8ARfJFPJPSvKYAePOF/xHHocfoMXwSlyeMsttohNN9kkf6QUPuJJKbXyD3XLyyDBf8hSMF9+ueUz/8HT4eiA/v2zHknurLTiSkHmHHDgAbHgggsGfB5c8XU0hNfAbcMVTquP9FD3nFNPP/V0fHqpT2fj2rN6SrO8wWDiIAzmWjsxEAvSYIoE8nbbbhu8VhASwyR0CAjvGRUYNCQiqCDPMksvHT2rJXdE7B0FXlsYAoUBg8TYMXuMgNDCIPRB/UMqwQYRKSXqV2dKKa9SKEuIyQvhtKsNRJJSyhsEGS7qJlAYQ67apvwYL2SWtG2s6mqk6Q8BigZliSLlWvDJ3JkPwpDhABcwPjhm3krPCBLKp5UpTE89EgFPmZfPHJtvTM698nAZPrmvTRRgbSuvHn2Ab3CXwguvKHj6nVLKDJHigRmrR18og/oMVykNhBmDFy1ggDw68FmdykyvZBzoSP3oWZtoAH2gAXDRd8/QIAUQbNADxQrdoVP9x9i9Q7PojTfZKkFKKfpVXnC0C3bq9J6XG5yES2hfQqO8tmAln/6gNe2uvdba2VgwhxQ2+SXzDu7osswHg1AZilaej2plhBBLKYU51S5cwiP0ifNAHeBhPtXjPScIL5nQBrwMjLQ5HVKuUh8YO27gyeDBgwPsOU7AKaWUDVN9I9TNARyBf3fedVcIBVIWHMHYu5RScHxQUNVlvsFMPsm70qZ7CfzxYbRVYKFv5qTgg3lSv2eUMHDeasut8uEE8Fh5+DFXr7kCbhccMS4rtD2qVTsyQXsdmSgjlCH9Lu2CLVzxDGwoncZuTIWOS15jg+tW4xj3xgCu8HKeT80TeAqYSeapzB24mS+w8k6Ca2gJTEr95Qpf8ST3+uW3/Nttu130q+gJ3ppLbcN9CpS+qx+toUV44X2hZ7zFapW+ksPq7uwJ7IwX704pZc823s2xZJ7gN1ihbXNqTtAOHFC2s4//4/YfzRa8wN/IIDwRHvuNd9CF4D6YwSk0w7EEl8AWPqIZcISTKw4e/J6N+7P1nC3wGytpcM4cuFceHzEf5kdSP3pDD+rTvmfko7kyZ5w5KbUaI/CaTCdnjP3iiy8O/WzPw7yrh9RUD51o9KEBgQYEPhoEGIiORqQcCtH4aKVmXC5KKY8MgTbjevHft0yYEA6UfYz/v6+pPkpSnnlnKWz10aP394Lg3X233fI+g/e/rb8nlFteSwZF/fXu3/eIssNpQany+9/nrq+3+svLzkipr57NbL1pjIcBYuVA+OH0hAZctjpfr8Zfw2D4D7NPKbOM/x+yve81xFL2fS/aPfiwupVvl7Vx24BAXqakoEgUWDhWz7jCM24Fgiels04f7xPvOI/VB41hRsD/v22TwcCj5fpBY6mHZ7yGPH+8c/pjrPDc73pJ+iSl1LriVOixXvr3UftB/vBudkYatTrCq8xwMI6POuZ6yAef4U899OU/9UE/9fc/5ZvZ31vhIQumxzjBWLKiZuVuerTxSdTZMBgqKGI2TtWwLFvdtv2zeUZcpTg332mw+U14hY1aNsFJ4gudlWxjaSnot+P4bJK2+dC1vLN87eQNBCg8wEYvddpsA2Hk884GaqfOuP9PqfG+80DAHJtrseU2Dk58cWJb5+GX0y5sSm97WP2wsRZ+WhJ1ZKGNmvLaaGiTodNEqmwBn3zUSuiMe5uhbdy86OKLQpy1ZyXBMRt7bWK04bl9m/KJdYfrNjaWNmxcdTSjDWK+s4B25C3J2GxmhP/6qE/yoYmSp96uNpHbaGwsZX6c0a3fwjRsdDVmG5EduYc2jcs4PBceZhOnjXbm1T34qk9+8BCTr25lapM82taH2uc2lsIFz8DRplyb9OAAWJob86Ydeeo56S8e55Qb/bT/xjjAePz48R61JWFIxgrnPYTD4KAOoVTwTlnlytjNj2OjzZUy7ZPNyvguOHpnY+/5v/xloL8yj/qGlmxMLPxZXkm95gi8tW/zqTrx7tJP+ToqoXvwLDQL9+AmeKJP/cAD9NchCjbawzPPaxO5hV49M0bHfpcN8Z5Jt99xR/6QVP59++35oA4wQN+lrHcSHqFO78V7t4eNfuNfjjB3QENtn9BHoQF9cSgBfFdP2cuiDcl4HRhiAykZia6EDKIJ7zsqOSEKrta2B7fNDfh7DtccVuAQiMKDwcG4il6gjE3LZT7dw3G8pMynuiR8Qd6p06a6fV9CF7X4S1bQUdQHjvrjN3wxV04U016pyJwYkzLoDY2Bq9/mpeSrl6v+2T8Er+CEMek/ei59xDvwcrIOLzEO5dCxg0ZuvOmmfBgCfFaH5LtZ3sMteDlmzJiAz+BnPuUpc1zacYXX5k1ZsFQe70CbDqLRrnz6TLaaB/DH9+CINryv19QwGKqZgQTlqEXIVT0KRGJpCKEgbBtVIB1BgWAdjSkRVPIiRuUkzA4iQA6bpCkYnkuQiWIBmTynUBA8nhWBllLKp4QwVCC3co00c0AAw7epyrwTiIcdelgQFBicDeo2sxbBUkZMaNj4juE58YFwhG8UHCeG8BbDS/WOGjky1EWJEmPp/S9+/ov8AUCCqtQJl8VhEy5OfcEEC/7Jg3mK58QoGR3HHX9cPq7TBke0Ij+chcfyS5igMpj2yKofmDiGqZ9oQp56S+bDpjOnwqA1cLOZXN/NhROiKAauTrVyMpXn5oSSYw7RudOhGAYUKRvcvKes2UDr9IwDR4wIfKZ2/MrhL47yI2DcR0Q2/Gxi3Hv48HyKE6eDuaUc+SAepZZX1VxQCGrrrLff8NQpT/gnhRKMGaCnnHpKPku/ZeedA3/Vb7jiAAljl9cz/JKxzAhzUMDos84KuEcJlv+5554L35cgkD9I2BLGTiuxqR9vp2we+fWvx7lnnx1nnnlm3tSM/igO+Lm29tt/vzC32pfQlj6pB/3B75RSiJ+HN/J0VAJPeAhOxu7e2PWf8WpTNniCkc3OZBXeAV61fXTvZBlhVOA2evTo2KWlJeC6fHARj/jyDjvEzZVC5RklVz7KpD07DC7PJfk9R0s+9CgWu5bfeH/yd78bwjrgMxq67/77Mn5z1NkQjQbUhSbQEHwXcsQAUd47fYX/HHlwXz/kN2Ybtks+eadnGjduXAjtY/yUduAROnUiD7zL9weNCDgD1nBQXjoDvEHDxmOuwOX555/Liiu44isMPpv1Gc3KoR3zjte8+cabHrUl46aHoBH6hHu4LG6ekgx/z/j5z4Pya360Ya7Ar1beMHbA3Fzb6E7WGAc6LDTZ1mgd/DBOsgqPAWdjwqOL4QtmYO1wBTQN737/hz8EHHTYxG233xb4PRyET/BbEkbrMAsykSzgcEBrjqtHfzZQw/daEJhXBy7gD/AA/uId6keb+Ly+kDmeadPJX2hX6Kt5wxtr66y337O8wQDhTKyNMOLCIYNJYhVCFoqPUyIoSQjXBmgT7BQkxEZoO8GjbFzEJCGCZX+bY7p17543LqlTEpoh+c26twRlmat9zJpNmfKwOl0baeaAwIuTJuVTjeAQBeX2O27PH5qCdwxIG7bajxTewSVCxSk8BFURNASt35RVDMseh5RS8LJglgQDZompFmVA/Rjq/vvuGwQTIUS4UKi8kzC1TTfbLAs7AoQC7L2r9jE8zK42TIdSR4lDMzaREuT6Y4Pk2LFjs8Gh7npJ4MYo590ROqVf+izUgffSOAhzG9YoZZ75TSjgFWCHTtH8A/c/EJwDBIoN5IQs4XDk14+MQw85JL40bFg+3UQbJYG5IyvxIALDc3PGmLz1tlvz4QUMMgJ9n3fmisDjxcIzhgwZEuadIFO2HhNlBQ7alJpSysYxJWTEgSMCfOabf/5gZJkLBpZV3ZLXb4qLjbZO2urbr18W7ubFYQAMYzhIERDGlFLrRsJaOJw5+sxMC+U9per5F16I7558clghBsuiEIwaNSqcBvbFL3wxHD1c6rHRMaUU6IQcMAcOJKCcEfCMzJJ3el/JFrwCvgpJhB8L9+kTlFQK6dQpU/PH+2zyh6/4BZ6C9uGZ/pFrjB00Su7xplJWwEid8o0ZMyZ+/OP/yzhbaNzJYeaSMrXZ5psH3qM+yfzddffd+aQyJyBR2tCRd5K5mljxvtGjR2fnhU295sJRxmgLDqMBbeN3/aq5Bmv7K8hn41SPfGQlJ8ePf/zjGDhoYD4mk1xmQDFy5JueieEPtvhhGaN+MVg4YEooHeP0kYcfCcYyWN1+xx3ZmUPu29OFhhlDZHzXrl0ipS75uxPkgDJwS3iKMfFm4xXmcb5553vf8MCSnjJt6rQo+oW+7FwZ5PB82JeGhXqEnuFpIyuHjg3w8Ma1VIiH26DOeWXz9V//9te8CZf8gTMlX71c4au5ZwThBTYU2+NXxgTXzQ06wK/xkhtv/FugeRuQ/6/CcQfakE/28YA5/LVnAQwYSebNoQfgSf5ZGQA/jjC8ucACXdL79MVG/IsvvjjzHqcXwlUGPMOG8wyP44DQJ3LASicHNRhrs9RZb9dZ3mDA6Eygk0V4ZHlNKVODBw+O1VZdLSDaMd8+Jgs6J6iYQELdh1XenDLF7XsSRQHRiWnF5FJ6rxDDECE5ZkIpW+Wzq2SDwvPaimwWpWhh5pSw2neN350XAk7PInhTSlkZdzQbwYHpOfJQPDG8KSM095gJJoJB8TAT7jwe8NAJEVYYnMqA0WGQysIfjJInEZ4RprXMzQkOe+y5Z/Z6wzEnO6TUqtAR7uI1v37EERnveWMWW3Sx4BGjHKEXApuwIcjinf8o0/rinY/KMYYJd7TAI6fed7LWxcV4CBeeNEIWDRofZQxDJzB9jAv8zQNBa2547cCTADFvxkWpxOwpRIS6Z8oRRAS28+wN+rXJkzNM8R3HWzIy8BX1e0/5pVBvv/2w6N3cnGHuPaGmTV5H/aLcUZrvuvuuwK+UrcfktA+eOid/GCOcBRuGZEopbHDGC8GJd5MBx+udUsqGBIXJUZ08dXjrr375y6DY89g1dekSFCIOm6Jswn/5tGGuwI63j2Knfd/bSSkFmmBEmzfGCNgKMzDHcLV7j+5t4KQYgjE6cXTtT3/2s9BnyoF5VE9b5un8w6ks4OkUJOODB1sPHZplSKFHRoCN+vCLckMe4SsptcoisKRgMjjJIhvgKTNgDUaG4MQiDg3tgKlnkrL40MYbbZQ/KuqZhA88+8wzeWWeMn38cccFWir4bn5GHnVUOO3KqgeYLrrIoqFfVkAocsaTUsr1FqWcMUm5RqvaQZvmW5+FeLzw/AuBd6kHLsELdCzv9Epw1yZ3jgNtaE//rAZQMuEvOOqT+TIHlEg6RgWT5oYAABAASURBVMEXNMwQ820cK2R9+iyiqvxxMPUx+DwwNvzEWPFy/EK9KaXgqICHYC+/VZmWXVoCjakDDnBgwPU7br8jfGNEnfJbMUWTTqTyrCSOELQAl/Ciz632uXzao7xo1LhK3nq6knWUb/Byiha81j/0wbDn2Lnrzrvi5r/fHMsvv0K89PJLQV6ZNwaSeYF/YCNki/7HuEIndD20NH78+Iyb5DWZBofRg3Yk+A5Xtc1wwUekRSqDnjxR38QXX4xHJ0wIBo35V29KKchmJwziW+ZZffWYZnmDwUQRwhjTmDFjsrfC0igF4tDDDs0Gg/O9WYsYoUlEjG/78QEJARNCc8w5Zyb+t6ZNi5RaGbXshfli4hB00MBBeRnSu/YJUiJejKH9u8Z954QAwfnSyy8HxcMyOuFPADlus3imakeWUgrKO+8RwYL58UBTUng54SklnVJVBBX8xJwc/0gB4/mgRKX0Lh5ipJQgnkD5KcFXXX1VUJ4pZJgfXGXEUIwJQ/XzYnrGA0aAeFf6S6gR6DwljF3eYQKmKGv1hseMGQoR+JUxVMQaqeldtpiaWmEGHrxPFFQCA+yUJ6iNEQytLOy+xx5x7333hZUKz3lxd9t99xCuhc9QpPbae+/AT6xKEtDqIWTwA7BlaETFYCgKVo30j+Ai/M03+BI2hFJTamo7frRtDHX0gyeZQE6pFY66llKqwJz8jKYuTTkkyeoCfGYY8+IZO/ogUJuq+aAE/PQnP8kfZ3PMLA8h3mr+0E+urPozZuyYoFBSgHmql1h8iayUVq/yv/6V55q30MoMzzZ69MLV8bTCBsw1r7Y59Y7yzBvIeWQObr3llvyhP/Nn/im38nVEYgzgFWCivZRSXgUA52HVKhalH+7BKYolhZAcub3yblOqlMEL4Kb+q4fyInknpZSyQjNgQH+3UeDghjJDxqFvypZnErrH03h5rcA8+dRT2YuL/wzfZ58cfgaPyVmKHQ8spXmO2ecI/YPX6tFHhmO/ap6MB/3wwBbeob9wn3F31MijoqWlJfPHlFI+olfIDYVZXdMrccbAidJn7YAFXKQYupdEKaBbjkjzcPddd2VcR+cFZ/tX47QClBJ6qIi+KmiMKbmP8JuCCVfxeKuhVt7wBdEN+A3aSSmF9/r09tut9ZgTfApP0Wcrw1X1OexM+A1ZQg54VtKYSgdCr3gMA8x8wRV9pNeUeSj56+VKHpJHDDljLf1KKQW8s2pz4IgDY71114tNNt44UvV/yVOu4MYAQPsMDLDBC4xfHeYCXaVUla7SWxWTnvbWW7m4st7DAw9SSqFceZZSaxn5vC/1+O2ZRL7iQww8z+sxvSsZ67F3HdAn3g6TRyCtt97nw5WXgpL13ZO/GxQvS9GI3vL1f+oSBEmpQo4qI+LFlAk+yCM98eST+YxfSFkIHANRDtLI41oVzwYHBJLcN1Lnh4DY1m8fc0yOJSUEKIxlVLVz75l7wg+zI3goVAS753BWntpU8MYzyr7VB7G+FCieXsqEPBKcZBxYJeNNonwOHDAw4z8DZWpl6IoHtZJx4kknBo8eZYGiph79gLMEvPrgsPATqwqYLUHPQ+Wd/srbAXhs6B876WMp1Lt3c0x+7bXgaaJ8vPLqK4GRE9CEwZAhQ3JW8Hdv3MbVu3fvoMj1XWyx6FU5C9RJeUDjiw8alJ+pk1d6ow02yEqS8iqT1xWcKEOTX58cV1xxeVA4hC888OCDccihh2aPmFhiymHJn1JqC0HwrB6T8Un6Zsw9evbI4WnG+/BDD8fUaVOjzyJ94rHHHwt8l/B/4MEH8rGqyoGxVReKOYWZ8gK/lVenPJLfvNbCWOA++HtWm7QPvymyVuSEWoCn+eMNRgeMgFq8RgN4P4Pee3XoE5zWB3y+to3p/dtYJe1Q/imODFJK/PIrrBBkC7p/oMIbdPuZlVeOJx5/PPASZfQf/vpdUqmv3Jdr++ecFeoEB3m8BwOKlfAaijAjj7IFPqt+9rOx4frrZ2VeWbJ0+2HbB++8PKUO9fgN7hRidGY1ghHOeDRO7YC7GHQGnHA/PKzU4525MD51Te9U+lzbjj6We05BMGAcWUGhjIKTPrYv617Sd+PgyFSXeeWh7l8Zb/Z8CONjUP3znn9WnvLls/K7/PLLZ51Cu8q4StoDH0b5yJEjs3dcG/Bi9jnmCAabfFIpx9iER/i31VPGmnf6hM/pu/z1lsCEocPIKX3Tb+MVxscxxmBi9OMLs88xezz9zNNZqX/uueezYQb29953b3jPIEyp0uO6NEVKKVeJV8BFc8OpMXevuaJPn4XbDGq4j2dr1zyrA52QtVYjyMP555sv+vXtm402qxoMOrSIt+RGqj8ptbZX/ay7f01116MO7pBNoZbueEx3qZbzKEkEFiHi65c8GISLUCVEX7oHuaRyX67Nzc059hjCQIRhldcHkauD4vbySy/lGHbvCa6UUkY4y7xiNnmw9IlygQgoZpSIUn/j2rkhYG/BRb/7XZ5zOMFjj2kYVUopewtTSlmhslGOwkjQMy7OOuusECYAb3iznnzqybw5XlmpqfLEYup+Y1CWwnmyJfkZHOr48+WXh1Ni4NdcvXqFfnhuOZcgHzp0aNz5j3+EE5fg8w9P+2GIwcQQMV/Ch8CmYFmqttyunzvvvHP2rBuTuNz11lsvh9TwiqGFehU24FZo+bOrfDbPjfFSxMSzUyYZbIyuwtgXXHDBLGzGjR+XlSGCAUxsgiQIfBjICo/5EnvMKytGlhd755aWYDiUNsHGnJk75W2m22///WPIkCH5426XXnJJUKIoTfaxnH322fnEDoqhvjPglK/XlFLKITMppSyMhTnADx5pRtnuu+0RJ55wYsYxKwNrr7NOrLXmWtlAAndKpKX6kysHDoPJSg/YEOzGDAZgmFIKStAuu+wS4pPhrvcppYyHKaW8mou/XljRoHkxp/j/Eksskb/aqn68mbC3iVKIEu8iHi4UibcWT+7Xr1889tiEHHbTp0+f6Mj/UnoXnnAI/7D6DV//Ua0kcHq9/sbrwTEBV64bOzaEOxT6s+IHXpSf2n6TMym9V1mBk+ArH+XLijcnh/KemR9wMUf4iZBJffGOvORZ36niC+QpeKvr1ltuzRvVGeHyScbhHVhTVhkFZ519dqAFhoMx2ov12GOPxcUXXZRp9Nprr82bqDlUKLR33vmPjDPqUef0TtopcChtlWcppRx+hV/gAWCCB8NPZfBE8FQupZT5vt+8444UtlcErlFOOSuPHnV0/OD7Pwgr0gwQHxXET+A6Pquc8uCo/pRSCDti6L4++fWwv+LMM8/MPOvFiROjz8ILtzka9MWBGgwc+opDGqwCoVFtqPORRx7OH0xUt3bqKcE9IZ+cVaV/lHTwgy/4BUcdfLNKb+V7ww02jLFjxgZ+e8WVV4RVR7gndMuKF1lpjIstsmiGmXkwf2gf30JXwh2t8JKdnAqMW23YEH3TjTflDzyaS7z/1FNPDfnIVvVYqYHbJ598cg7LRB9WRDmL4Ii26zHN8gaDUAyTWCZHDJqYSh4qCgArGwLxjLS0tORskHLroUNj6FZb5fvaP4TYEksuGRCI4oC4bRBVB6RUJ4QQf1yUBoi35557ZiXCZhuWsqV5FikFo7b+xu/ODQFxk8cdf3xQKK1eUbiLIOc5taTKw0lQi6P0DA4yJDE0JxsJD8J0+i7WNy/7F4jwrtgfAQcxNsKFV8RZ5S0tLXlpFu4tusgisc7aawdc9E47AwYOzEpVqQsdCJ+hTPEoMib0hedSfvQxatSoLHQoWwtWCrRQEcaHNjFP4R2YOQNcf+eovFql/nq5EoYMMEIXzMHNJm8rA5wHluYpAZQYwrn0m0AZUin0l15yaTRXTgLzs9pqqwVF8pBDD4l+/fvl8BkC2JwTVGBUypcrJY1Q5iVMKeU56jVnr1AXPgRm2h5VeQjBHM7gJRSka665OvSBAljqq8crg8YBEZQn44Ub+CI+Z7/LEkss3jZueLL3XnvlLyzDTUoVL6c9OmK00QBPIb6ID6eUgqJgT466P2j8lH98Xlm0AS+t+qifx1GImWfrrrtumCNzqQycRy+DBw/OitoC888fyqAxRiTFwxjk/aB2p9cz/QVPcKUoCgGCQ55T2NHh8L2Hh5ATY4bH8ASu65O+wyMef/D1DM+Bbwxf9yUVuVTuORTUX+7h3tKf/nToy8knfy/gKLhxfqGRks/ccMoxCBkAUnNzc36tX+YTn/Gbob3H7rtXXvNuYZx4Htwxz1b70CR5jGY80w7jh3IIDrnSDvhDnjsVLqV3jSy4wFjVz379+gX8Bg9yHa7hjXCcsc8pqJt4DrgaB1nAQIDPylM+8Y+ePXsGhw1cNK/qV7Z90ieGWkop8xCrx1bcwBvfwMusIKAnbSkPR8BSnehy+PC9A7zBGOyFSNrno1756y3Bmc032yzArPQNna+88meyg2Lo0KHZQIXz4EA5h8OcL3Bwzz33yHibUgqyVj3gpC6rxniwlQO4zmiFcwzhlpaW7Agxv+iHHEF/5mv4PsODsYCfaIc84TDGhxjcaA3vgK8cbehDmB3nw6DFB2m6LtP/ZDDU5Yg+Zqd4Y0xwKQbRCA6ETZkjnCT5MGf5IBPmJrmvTZSOdStF4tnnnsveJ8QICdWB0VHqECpjAQKqCwPxXqIMYi42mhJWkLC2/sbvzg0BDKjMsyuGAeeMCj5g+O7hESWWMg7vKCpwAzOTDxODT2PGjg24pjyFfkiFe/ALXmGQhIsyhJE8FFH4BsfURyDox9prrdXm5Uqp1VNLcJX3hI56MUfPCErMTT8xUIIypRSUW20yNDBjnhmeKwwaU9SHekrghP7BmeCRCE9jBzewTynlk0LArPRdOfDnFbKPg9Cn3DAQlv700sHzZJ4ox+rCK9RdypcrpZdxpnx55rrwQgtl5VQZQg7MzRfYwhFG2JNPPpWPdpRHmXpNFBFjgLP6SBlhMMM7CpBnJcEZOEpBwoO32HLLfAQieG+88SYBBhRKypMyKaUcCmbOwNKz9gnuowX4px6rCuZKItDld6VEmSuCXl3mW1/8xq+9g/cUDh7vq666OhgapS/q6YiEP4Cnq/Yo63AVbpAX8IFRMHTo0IA3eAc8llfynpPqmWefDR5oz7znxFLOfUkMAIqN+5RSVqxqjQqwVb++DBw4ILcHrmAM1spJYIQnmD/9NPcF5+VDH+VeXfry5R2+HAwJfTI/eCXFzPyXeswJBcxqw+c+t3oO09FeR6SBlZMFXtW2BR7wB/56TocwB2CC9+OXcAr+2JsgT8F543aPPsAKjMAlpXcNEuNHM+ZQ3vZJn7SZUsoOSLAGK3WZp5Ra9zqoA14rjz7JDX3H4zdYf4NsbDIQ6C+U5e7de2QvvPz1lsACfcK50je8d5NNNs2GD9kDBmBhLsg/82DMntvXAP+VNXd0NL8lc0EfZOBZFaD4qwO9ede9e/e8h6bQBPkH1sp4p2/q1A52GzqSAAAQAElEQVSehwemlEIf4C7jEv2SIzfdfHPsuceeYV+PtusxzfIGwyc9KSmloAAcfthheQnvv60fcTsRAQH/t3U0ys3cEMDwjjn66IrBzP5JDHS61EEY8gxT6FJ6V/BNl8Y6uFIGk1Waouh0ZPOMHN7LIqg6su2OaiulFDvtuGMIaSF8O6rdj9IO5W5kterDePso+estD7zxXQQ4XG99+2/6s/HGG+cVvaIE/zd1dFQZThcrjgzPjmrzf2mHIo6HM1b+l3o6Y1kKP0O1paUlihE4PcbBKD7u2GOz8ZFS/crJhsFQzb5NKuL4nnzyyequ9d+rr7ySN6a03rX+tYmIpSlUiFdRvJoYTuVbc0TeqGxpFKLJL3bOO0u/Tz/zTFvMuZhclrt4Wd4GeST5nnn6mRw3Nz0RVFuNNOMhAHfggFMrLPsK4fEMPvLMwy/eB/sY9FYep1X47Zm8vCXubQT1Ho7CKbjkeUnC3LxTr3C58rxcxVrCbfHyvCnluT7po/bKs3ItdcJlS+zy6oPf8lD0eAdTmjFMUOiOcAV9AkubCI0TrBx5B+7otD2s0C0aNy60aiySumy+tUek1KU+4wWff1enPQhgrx9ibPVNnSUV2OkTuOqTOsePHx82nHtW8vKggat+mjO8SD/k14YwgpK33q5gBQb6bQVK/8ACbIVyuhqH5/DwzTfeyPzwsccfz6Ge+LSN0t6DCdjYhKgOz0py77m2JHWVd7VX86tO+dFTe9oDS3NQ+qQs3sxj7Hd9ptZewVVjl4wLToEZHIEv+EDtuJQyXrgNHvAUz8CDwEZ59KJ8qVOZ2lRw0vyCrTLqRBvKkI/aLWW0o2+lTrwGj0N/3pV8H3ZNKQVa6CzOtZRS3udo/1j7MYExWIAxuHkPnuDhHt8CQ/MCPugej7K3RFn5P+lkdYhCm9KM4eH/aTzgYvx4BxyqxS1l8VX47D3cg1Nw3m+wVAZNqAfuwXfPwVp5V/zeezwcXte+l6ck5fGj9vSiTn0oc4Tv4fPq0V998kxbpa56vDYMhmpWECNPobgyk1c9iltuvTWf9+13SSbY5lNx2k7Y8NvZ67WTDFFsLkLQo0aNCke0Kg8hbKR0hr57cblnnX12/OmSS/LmpIJIkPL+B+6Pc849J5/XLm8jzbwQwERsonI0njO8//DHPwRBbhOaDVGOf3QcJ8FL6bV5igDBwGzetApFKYBfTimBc8ratIa5FchhqDzScFBcq5PAMM3yXp02TWrz1O+fGjbhY7Ty+OCPTXOYasnv6h4t2MzovU126MdmOZu74bJ8MzJREn974YV5c5uxicu1QduJTjzENp59/9RTA92WfoKtDa9gbQO3Td3qmTRpUtjDQdA4blB5PMAGRUJ+7NixOdbdBkdtgU+pE307AeioyittTm1EpziX965//OMf28rDB3Oin/DCnNo8aR7llcyNfOZVP6XXJr8W+mF+a/mS/PWQ9Mk55/gtHHWlTOKHcGn06NFx3PHH5VAZ+IO/wn/f/oDreKvx3nfvffmL2H7DW7HF6qgdI2HMM2pjI5gzCmrf+60/v6vwY2TFq9EdOtMvsIQbaMq827BI4VWmM6VR1bjgorGMGTMm4BwYOv7UM3QO38uYwAO8HW5AGXW6DPjhURQr8MFD0IHn6KCUdVU/2oGv+Iy8ytg0jkegF3yLQ0N+Ce2gNXDXp6uuuirLPveUM3lmlYTnwjX4DB/RgLkQ325u8CkbbsFx5FFH5Y20YDey4iscPbMKnGrH6XQ19OrAAns+4CR+Kw+5iIfCX3iPl+Il9DOrPL4arpwN+/Dbvj881YZpe3yUVx+ehU68w7PMDx6rjZI4OvAweKs82W4O0QKZgJZs0If7aAdP0l914/XykE2lvvdc6+RmljcYECQLnTBgsUMOc2OiKWh+lyROzoY4cZ1CAoYPH55jaouHVz7M7q23387nWKuPMPRcOxQNyh1BzwoVp4zBPv7EE7LkJJ5TTOa4R8YFhp0fNv7MtBAQQ2zObbQVf4yp8YrClRzHutOOUWJJCVOeNGE+lHMC+cEHH8jHJRK6mJ8y4qp5hAiYAjjeFQoDJik8iBEA98p7q18MZ5sVnVBzzbXXxKuvvRrXjrk2K8mUMXhb8ruqc8Jjj+UNZeJEGcBiXnle1Y/Byjcjk/746BlaBTd0LRyDIgrePtwmlhujJhz0laJpQ6uNiDY64wl4AaFNYRfHyqEgnEM8q/hkcahO1HFVBu0SIOqTwEI9yy6zTA6xEV/es2dPr3Ii4CgK9oKoE16MHz8+CBUxtTbOUZ4Il1yg+sOb5QN5LbvsEvZTUMR4JvEm/X9x4otVrvr6BycpPfDUmOAkRwxHCr5nQ/GKg1fMX7w1FsaYeF/KvnhuG3ynTJ2ajw6lCBD+eLI4e4oUPltGfPPf/x6TX389x9Wbyw8KATGvP/6//4v77r030xHllqC3f0gZm0DtDTJXDOFSd2e4ghk5I6Rit912i3XXXTd/aZhcEkolzEIstrjqMh48wJygYbCx8dZmZR+ccuQmPLZ/ZsiQIfmbLeBUyrrCWfNic6f6X37p5WzY8bDadyGW214RG7Tll+CxvoK1Mvb8mSuhfvhhLZ+Sf2ZO+ABezkkhwWc6BL7jHQeklZQXJk6MpZZeOtCL+cG7KJzyzMzwaT828Ln3nnvzKXI26Nt35OhvCri8DLBbb7stBq+4YnAeNDc3Bx56z733ZMecfQQ2HcNN+0bBEV+yDwT8OQvgs70hZPLFv/997FrREh2Q0YZfaEdiFONZZKw5Ii/wtocefjgcZqJOBgdZii533333vFGbLMIX7Ss5+5xz8gmJ6qvHNMsbDJQg32KwMcVmFR4uz1JK+WzeqPnP5iCMzNUmGYLExjwKn2wmncGw/HLL5Q2knqfUuoyXUgqff/cMkkE+CosyKbXmUYeEUVJKeBzdN1LdQ+C/7iBhTvG36ZbXA14xKimMPMq77bpbVo68w9BsuhSn67x1Xr7ZZ58jh2sQuAQrXFYOnlpKLh2DTwxbZSiZ/fv3D+FC5f2A6p6Xhicdo+vd3Dt6dO8RCy+0cDjdg9LWXhhhmr/+1a/yB4OU696tW4XjXcNmfcpGYdqljRlxFRqInggC4+KJm3322YNQJlwoqRRyqwHy6KN3YEVIGIvy5oTCSJmRj4JJ8PhwUlFqwMPmS4JDu7VKkfoZEY5nJjx4p9SjPQlfsHmc4UJJNsfi5LUr5tl8mU91yC8tuOCC+bsFQ9ZZJx+zqr7Zes4WcMnq0vhHx8tWVwnsnRaybMUjGUNwVmw0/KWIWrk1ZnHT4AsOTnWxOXDfffbJR/0+/NBDeX8YYcyIMEeODSWEX3n11bbx3lIZDLdXygKFyiqE1a+2l9UP91Yoll5m6fxdjJRS8P5REHgIfWDvyaeeynSiDzyO+HVVtFP8o5hQ1HlXDz7k4GAMSJROXk+GLZjB1TIgK4N+gymjlsf1hr/+NX/HAR5S7nm8TzjxxGCEM67kL4lyZC7LKsMGG24QlDbOBQoW5ezSyy4Lil4pQxnmedUW3ODA0ydGpefwoeSd2a/gwungFB4rt2iCsZpSq47geyTmpkf37jH7HHMEpwVFlIFmXuqB53bkHKWUgrOAzsZhYhV30OKLBx1NP8BuxIEHxp577BEcRVYjes7WM+6/7/7ggOEg+9ZR3wo4RrY6ihy/f/mVl/OGafjNycSRg1YcR7vKyitn41sZjjbtSOqz6ZlMofzfdvvtcdedd8YSVX/sa0VPj1TGg3rIY/nogL6FxNBgMD82YUKQneqrxzTLGwyQgSL28ssvZWWHwnXrrbfkuUqplUjzTc0fRF1z2/aT9wWCIWIP5UuptQ6/CZumLl3y6UmMBoguPjel1jzKlMQY4YlTrjxrXGc+CFBM4YKle4o8oUlR5RGk3DrZgWJF4FIYrRzwmq/8mc9kYVGrxPPuYZCf//znY/To0e9ZoYLnvB5zVkKGEvbyyy+HJdjzzj8/fnfRRVmBBl0Kkz5RLChzGB1vI4XW+9rE4CiMWhgDz4z3+ti9R/fABN3P6KSPjG8nmmDohabK1djk+bB+Ul4o/BRMsDBuhoMlZiEflCzjB2NGgvrUhX5dJXM2bNiwcKzkbrvumhV9fMd58wwES+I8iRRq82NetcsDfPbZZ4ela4qsOVSf5L25EoJkdYm3kRFhfwMlvB4NBv0Gn5f+9a+siMNpPBOupJTyqU8EKmPBCg0Pd0opfzzJHP1r0qTgEWdAuweDUieDyTP3khVh3j5zpC6hBwyyc887L5wuxrBGB1tsvkVYtYDz6h4xYkQ+cniN1VePI772teBlpESklN63ry3q+D8KEgNMmMRSSy4VwjHgC4MVPvGuwsdaBcXqJhyGZ+YJTH3IEF+RjyJmBfOE44/Px3aCL5gyktEY5f/V117L3yBgZDlSHH+zsiCMg4LmOwrkbAGdfgoVFDplNZWnHO14bj78LnlnhSvaZyxJ4MUAw3PgIUfjMssuG01dukRldbWBw3y5KTzN71khGS/ebKxon7H1SiXbiuGUUsrOW8r9wQcdHG++8WY4fYssEIKONyww/wJZXsJ1uMqwve3W2wJOMgi0gU+Zl6aqPvfam/bWW/m7Ln6XZyklt638asqUmFrlSanmWXWvnym1PpP57eqZup1SRU5YAfS8HtMsbzDwZhBYkye/HpgdJnX11dfkzcsmDCKU5P7fJfkYBfIQZAQ/RPWc8vXkE0/mc4F5aSA25PBOfqn2t/IQ2PNGmnkhQMkkIHnSxEYuv9zygXkIG3L8HoURHlEmXeFFgUYtflAEKInbb7998E458o2SBKcknimrYcced1xYuuV9hPsU1X/efXe4F1cvbEGIBy87etCW8pLfkt8Sz+HPf/GL8GEcdTrZy3t97NLUpY2ZejYjE0WQp9URjeBE+Hbt1jVefuWVTOfPv/BCFIEL9n6Drd+Y+6R/TcrKbUqtwsdzxr6jZimVjCphTJbCKe2UMYaF1UbjBiv18ZpvuOGGIYzjU717Z+WTB4qn/NZbb42rrr46KGKMRn2wyiTUyxGY/Qf0D4oCY0B9+uDKUOEtpmgJS0opBUUPrkx5c0rU23/4oNUVoQHOLO/Xr18+NpViOHTo0DBWqwV4JJiZK2NFHw8++GBYLdh2223j1ltuCcaVfOaIwfGpeT4Vs/XsmelHWTQALnCa8SDsdNz4cQHnM8xvuzXw4D/+6Y/x95tvzh8dpGjIC+6OxOUEQqPwJqVUNzj9UeYVrI2FA0GaWOG58VkpYDiDIxwqCpc6wRLuwCEGLVjx+psXe4HUaX6spuE1aMu8wFUwpcQuteSSQdltaWnJ33YhX3lU8Qf9YHyBqXk1T/iI1T4GBpinlPIeBjDvUinG+qRvs0oCF3MghMY8WMF0NRf0hoWqlUV5CjzAj0MJ/2fYleezwhX+GDtvPQcOA8s9vQuM4PeDFd9grE6ZOiWsNHKqpJRiyJAhAZfhJUPB6qT3HDAMpFR4gQAAEABJREFUbSu1Vs7VA5YM6RcrhwWegN/MPtts1SpE78xvovrPijDjVpvogtN3wQUWyCt7nE3k8dxzzRULVPPH+NN3dGBula2qyP88zz/q8M8sbzCcddZZ+Xxh3hceUrHkYo15sHhsCX/JJhVIZQ4RKMbpd21CrPMvMH9e1iboMNmf/uxnceqppwaEpYCxbClqFArCioEh3tsSuDyUL3VS2DCAlJLbRppJIcCTam+C4V155ZUhZIXnX5iSuG4MjHJlGZo3lPIqr4SRwUlXCiyhbMPV+b88PyypUlDHjBkTlEqK2fjx4+O8884NGzmtAjBIvvmNb8SIESMCE9Wm9ryHv9ot7cB3jJDwpgijER7vbx9zTI655DEcPXq07IEZYrQ8JvnBDP7jdB0MHO3pCkWSx/XMytixjE35pERZKcAPKDSUFZ59qzsEhLAlQvyJJ5/IG0fPq7zU3/veySFMyVI0hQeM1WcOeWOFcVGm0DSljEEozMCy+dRp0/I3KxgYhJPQtMUWXTROP+OMPD94hfoYEgTgvyb9q1KiXspCjmLGuPN1U8YdrzBhhM8wLOHJCy88n/dRGW89JfyOJxqenXPOOTn2mFIrHOvcc88N76y0wWVhdTyq8A4ceMOFlcG//gMGZPjxxsH5C393Yaw7ZN28DwF8GQcME+F06hWuwcDbeujW8a1vfjN23mmnOPm7J8c3v/XNoMQK+YIfDBCbc839Kaeemo/IZmjz8hLk+lRP8Px3fXl0wqPBw3/m6NHxq1//OitHFBd4aHw2PsMxYy/1GB9cfePNN3IopPLgyXgQPuHdscd+J84//7ywIiD2e+jQoQGHGXNgaY6VgY9WJJqbm4NTRLjH2dWcvzhxYg4jMf/4CNwl/+C0MpRiCczhst+lfzP7Fa6bo8I/D//qV+Opp5/OzkywIgfwJnz4sksvDSF1DgPAd6xKczTM7DCqHR9lG84++NBDcfkVV2TnFbkDB+EcBR6fBzv6lr1/+AsHBAPDpn94h7//4fe/D7wkpRRjKrlJDs47zzwRlQpGBoC9uZGHESeMfc455myTAQwPupx9CtdUTuchlUGywvLLh7CyX5z5ixBFwFBfZuml8+q+vnD2MCyMAa6Ts4sutmjU63+zvMHAMhUqQIngvTPpYtn69OkT21aerPGVkiUxIAgMCMr7Kx/CrZ3YnpV3a+XPrByUJ4TPAPnKl7+cPVoYrfjxFQcPzvG3hCTvCSbsmTZ4YljGrE4CD/OtrX8m/T1LD4tA5QXF6OGA+S8bEhkTGB88IpgZmWPHjG2DF4PSUj/ln1DGfNQjzp0R0K9fvyB4MDuebUuwf7788oDHPDEUITivD2IuKRJwVx8oCkVQq1t5+eA1gxnjhL+UBQyPYoc565zy8803b15Ncz+jU/Pcc4eP5oCXvvBMC8sAH4Jkt913y+EVYM0DazwUeUo/pQvcKLBo9S/X/SUfiejZxIkvxrXXXht77713XjUQK67s5VdcHniKsCUCgBJv5VIIDOOCgkSRNZ9garmbwCCIpk2dGtf95bqwIY4RY1XE/FKYj/rWUUGpVac05c0387jMHf4EfygST1ZGTUop8DbjradkvIwcuEPx99sYrVDhiTYAWhEAOwKX4YQXCs2zMsP4YojBe0aaVQqe15VWXClaWloqB/fbecM0HGdgLLPsMqEd4TfozNzDeTAHnyWXWDJW/9zqedO4OSLQ1U1h6LvYYjk0CU1ZocL3az2B9QTXD+rLdttul1dkrqlWrpZcYok49LDDwp4PG/0pTOaAgj7ffPO1FWe4cUI88fgTYdM3WcjhYEVh7732yqFGX/7yV+LaSqGCv/Y9FXiaWzA85OBDYsKjE3KYI5xX9qCDD8onX1nNPOzww4MzA1/Cn8y3jdCMRXVQ5OC8UCeOEAZ8Wwdn8h8cNbzeYubpGiutuGJ87+ST8wfp7FXAhzkuPr/eevljkpRRfAsdWFmeycHzvuGBkW9wDKtW1in8+KKVGfhDj8IPBw4alPnzxMpQpWPBb/yfDse5g6fC8+bm5qzz4RF4KTkmPHjqlKnBKUMnZCSTdWiGkZxSygcJkIlk4fDhwwPebrzJxgGvBwwcmOXDHbffEVbQ8Ds06PAGNGi+/Yb31//l+jw+K9b5Rx3+aarDPnVolyhOEKY0CtEIL6EgrHdxr9IxlSeVkEkpZeUCcpjsUq5cMT5CjpcYQ4YgvDk8lUMqi5NRYbmWAqIMo0D8sTYkyEPhSyllBJOnkWZeCPAsm3/eN/PPSyc8w9I8LwaB3q9S/AkJGwavvuaatm95YFryu4IQBZ9R+tOf/DSGrDMkhwOon+GbUsrM8JyzzwkrCQX/lCuJoOJh5/0dPHhwpFS5VqqXlmILQ2Uk25ylXvjMm2KFRN8JLcyYp36NNdasG4OBYsj7hilXw8n/jEn8KhhvteVWef8SAQKeFERM3bz834//L1ZYfoVchtJJiNxz773BI8WDJd6VIorWwZ/RcPZZZ+cvpapHPjHf2qY4ac8qA56TUit8c+XVHwrYD047LX7x818E/gLW5hbv0Q6FOaUUFGUnKVG68nz/9KcB/lZBtXPHHf+oFIwVsmFTVdvB//5zc+aDdxtfhOcppYwr4uE9I8wp5v37989ecco7IU4R4JVmrBXjDx4qQ3ijG+NXnrElzzFHHxNwmhFgPj6od/0q+gJPbeLpfivD660+c26lCA18UPl6fuYgDzBjoBofPsJ4hk/o3Mpibf/RBU+qVSzKGHmkPAeEOQBDxttZo8/Kq+aUrNryKaX4zMqfiR+c9oPAF+Co92usvkbgcZ7BX88oV4xFnl/9BHMyl9FNhpp3z82r/LNCgn+MAnwjpZRDJRkC+IFN6gwJfAHe4z/onozAu/CgWQFG7cdIp0Lfo0ePziFHlHw4ZOWFwcn5gpeDFXlFfqFr/KbgdnNlLNg4Lh8clZceiP9aib/jjjvywRIcd/BY1AmHG9wllwcPHpy7JSxUnXiQd7X0pj9oSEa8XBsManzfvos/XfKnynGxczTP3SxLXaamuuxVJ+4URYxgQfi8sR93KMowTCgnVj0+bvlG/pkXAryf4oZ55up1lCml7AUXAz6zCTDCh3e2S1NT9mTX6xxQyDklCNJ67eNH6ReFtWWXXcKpJ7yoH6XM9MiDJ/NiMvKmR/31VCecYcTx6lulmVF94xmGw8LIZlQfGu1GxCwOBAYyA2N6e/1ff+ONwGO2GrpVm6OuHkHfMBg+4VlhKPDUUi5Seq8H8aM0RUjyyhBOrNOPUqaRZ9aAAM/SZptuGsJX6nXEPChWzXhm6rWP/0u/GEI8sCl9fNr+X9r9qGXxHyFtvFYftUw95+vXt2+svdZaQZGNGfQfL7zVNB7DGdSFDms2pRRWdlZbbbW80b/DGm7XEJhb5W/IwHaAadx2OAQYz3gq42F6NT7PPPMEw8QphtOrjU+i3lneYOC5EpMmhEhscQEqL66NkmLTJk2alONiX3jhhfL6Q682oIpZ5iEpmfxW1rU8+3dXRkNKH0khydXYLGMjtbF4UPrg3jj0h5fMu0aqfwgI6xG3/UH4AjfE2TuVp/a9JXwx90YHH8Rg1r73vCT4ATc+7D18EevZ3sMIh9CD/QvKlnrE0epzqV8fy+/OcjU2NGpM7fuMhoSkGGNKKZ9CBAZCB8XMgiV4ex8f8J/5MDfyfcDr/Egst5jbfPMBf7Tnvf7hV+b7A7LlR+Cf0kfnH7nQDPgDLnC5tmnz0B7HUkrZ64YmCo+2Obn8ri3vNzjL+2HzAYbKOulE/vYJrM03OvCOHPggevCuHhO61Xfj1D/XCRMmtIUyelab4HctfoKfE8SUkw+tk49g7r59Amfv5Wv/zr35VD84ui/JHIFrua+9oiv0pW7PzdeH5fW+o5N+SaVdtIkPwt/yrPYKluAKRiUP/Kst45Sel15+ua2YfMpIfre9qPmBhl6bPLnmyft/ahvswNBbdakTnrt675l37ZNxmT9zZx9P+/f1dm+fgjGVfuHLH8YrzYVDE2rn0TO4SucrdaAP8hYcwAoca9+XfK7Kw2tl3EvK6Qecdl8SHgOu7vUbvvtdz2mWNxgo2vYdiPEUByteUPymY+KcUiN2beTIkeEEG1+yNZkYMqSEHH57huAgk42fo44eFffdf3/+YI13Tjw6c/TogGTySIhVGe9rk3fqVL/nkE07fkvKKCuPvO5tiLRZ0HN5EYiTPhC4fosLrSUK9TRSfUIAsxFHL75SLDVGVdtTX/AVHykeUkwrJRdeic2kSGKAzo9WXtw+oVRb3iYv8a826ooFp6jWvneChM2O9t6oo1ahI9ycIia2kzdETD5890ErG7ThXm1dneE3+sG07Suwudx9bb99EwC8naK27bbb5BOM0B56A0s0Z48BWOEd4FBbB14iVtt8CTOkWNXWL695U/9ZZ51V+6rtt/7Za+W4VQ/xLHG0hLn7zpbAbOzYsSFmGI+q7b/N23AMzOGp2GynRIHb0UcfnU/kcjIV/EQn+HatcEYPhx1+WBxy6CGx/bDtw/cB8MnShrw26toPgX5++KMftvFpeSgD4vbVSy6cfc45mW/bH0LAy1PPCa7oK/6PdsVG24sBXmK5ndQC/mUMcNnGf6dPkTn2a9gX88PTTgsKjvrIRfgNXmKua8ujD/wAvPCr9kqPk47Mk0MUhOraO8GYsY8KPsNrG0mLfEIPN998c/ggojEIwbzkkkuDTCOH4Ufp+4y44nE+fIfH6ifcwjPBAH7aeE93MA79c3XcMt4Apx2mAJ+NVxw8fg3unu20407hlJ2o/vMc/u89fHjAR3xfW9Wr/A/fdvKX/SROecsPP+APg2LUqFGB15sHBwGo2zP9wZMcMGCjrr6WKvweM2ZMPkHMePURXjgtq+SppyvYOPFo2223DbA0bvw8j3u//YIuZ+5Kn+GtsR99zNEZvuaM7LUXAl7al1DK4OkSmOP15sN7MqDU54qPm384jeerjyFwxNe/nk8RGzp0aPzlL3/J3yfC70dWeiWawqPoeQ69KPOvvnpMTfXYqY7sEySw+92GTcwQISOKOXv1ChtnvMes3C+80EL51BmIifFRxk0wBkpxsuv9zSlvxqPjH41LL7kkRo8eHRQGYQLKCilB5BdffHHY/KgsQizjhTROiqCIOLYRctlA48g0grC8V69nTgdR/qGHH8p9pTjaAAgB77jjjnxmuPEoi6BKO41r/UIAbtjDwsizMct8Eup6bK4pik6TofCIVSfg4QHDwCku8EY4CoFMMMMlzF95iWCwIdTmLBsZa5dZ4dfPzzgjGAKEmXrhoHJSv3798jGNytlfI5/wKCF08sE/+TpTAlPKEnpCJyml93SfQgtelJqVV14l0KOv/xqv+GqeIx4pAkDsN8MN3EslBD26p0xQdpQr71wdf+sYXKctEXKe1Sb9o3BcedVV8cLEiXl1w/nghBPBWJu3s/ymsFBqCVQ4V9tvGwkplxRU4Sg2n75BnI0AABAASURBVDt5xxzBa0v3hDfFwAZz+HxTpWCWOiisTvgZNXJU7DN8n7zxltJa3vPGqlcb2w8blhUJ817em0t9cGLY5ltsnvm0zew2A6Olkq9er/qIBxgTuoer5BKahaM+Egj+pf8MAnLICTzyk0togaLjvtA0BZPh4B1vdSlPacILwMuGXCe1kYflvTk2ZyeedFI+dMHGZoo2uqJ077rrrvnDWowTZSh15kBIFCPeyWSXXnZpPvELX3Rc64yUZVZZbIxFe3BXv50ihUcwRPHIC357QTa2ohqQPE5GQ7NOTmMw+D1mzJh8ipR9aQxRhtxtt90Sb7z+elUqgkKL7zPCKPZClK0ceuk5PUJ7Dz74wHsMXu9rk/llJHNYOH2Ksf3Gm2+GvVjmVLiNRJak9C7ve/DBB/OxucrTgeC/zer0nnp0VMAnm4gdoW0/AB2OEXDCiSfEFltuGZxahb/iqXQ4+t33Tv5eDsHDlzle0T5eL/T0Nxf8Jq/K+YaRk9ngPZ3vyG98I/B6tMIoL/B2TCqaoUeCF9rQB/ojQ2PIkCGB72nHih+ZAP/xd3ivTUdA19ZZ6q6X6yxvMNiYyauEyUI4ihfB9Fi1hAtRmrp0ia7dusXDlVIOqSgDLG2IgKhPPfXU8GVL3leKOmJGYFYVGBE8L95BYM8hxPnnn58RcWRlYSLMggyYDw8AIXjFlVcE5gJ5ILe2nQvsZAtMyE5+yiXmjIkhegwEI0LQPHIYjGSMKaXSTONaxxAgzOGfOGJxk5RMDE6XMRUGKIFLaMED8+4ZYc3AGD9+fD7BR/mVV145br3ttnyMqvKY2c1//3s+5hfeMjzV6Z2EocJHJ0EwAghBeOSdxLigvFHA4BWPFeVL2+iC8SJfZ0rGAU48QhQb9Fvb//U32CB/8dPeDIIfXMc98kg+7x98wIvgIXA33njjrAQ88+yzbVU4q5vSRIiAtdNP2l5WP7p17RabbrJpVqbMT/XoPf+sJqB9wqacFiO+27zz0r8ncye5IZR56cC9PbwZV/DfuOE3fugKx3lcwVAZSpe9JBQ0CmaBHVoxp067My+FDxfQNM89d/DqEeLnVqsH/fr2i+bm5vI6b9jnjWckPPTgQ+EjWfYuUJbMAx7dlrkOf6BdsAVj3QMvVwoMvGFIMDY9kyhBjALwBDd4RomB795zCFA0vedAcNIS2HonkWngA17zzjdvmDcKqncSJwYvLziaJ30gr/AQR+QywB3LWtrDT9BRy84755OzHn744fCRQ+9918hqSG392ujIZPwtLS3Z865deAcGjCZwYdQ8/NDD8drk17wO8pmeAHZOjsK3zQEevuqqq2bcUw7/WblySMBtBY2bUklfINfBVVveSX0WWSR/uXvQoMXb+Lvn7RM84Gk3D3gVOIKneWUMWD3QtnkpZT0/79xzgzGz1Kc/HW9XL+CG05vIAzhTPaqbf2j8nHPPiW2q1QUnJDEo9RH9Dxo4KH9LRf/Nk07jEXQ+Rhi85ZRQByMVvyFHHac9cMDAQCucroMGDcrfjAEnxoO8eEgtr4ffjiXGv8AbzzJv/fv1y0YJ/NUv89CveqYu+fUHTsD7p595OkSn6Gc9plnZYMjzkVLrObqYJkaGYBGqSUTs1GxpypSpeXVBIYoCIlx1tdVi4osv5hNTIKkyb017KxCz4+B4dNTB64VxI3j5eMcw9Z6zzRYYpzol5SEwRWzttdYOyobQkZVXWSUgsI8TEZrKbrLppnkFARG89K+Xonu37vn8XwaK5dE11lyz7QuE6m6kzgEB+NHUBOMiCGI4ASf1PqWUPwpImed14jXhwWYgwhuGofKErvyULwoOvHOfUooD9t8/Tv7e98IyKW8kLwqhTSjxRGKsTV265JhxX7KEX8qWpD5tUqAIHc8JPEoXYeK+MyWw+nQlFDHvlFrhXtt/wjWlFFYgORN4psGbksOAMj/qSCnlIxB9kM2zUgdngbxo2TOesKuvuTqOP+GE4JEyZ4wIMPS+NoG1cBLK2vLLLZeVD8pz9+7d84evGCK1+TvLb7Cm7MPPgpu1faewWFEQbkHhYYzCazguX0opr7RE9R/Yg0n1M/8jqOGso2x5sCmXBPQPf/Sj+N4ppwQD3Hyol3Jtfjh2cuHqD4UP3XEKMch4Bs2RQyzQIT5cZavbf5QgCktKrbjcZ+GF83d/GEE77rRjgCUaLwOgOFGCKUnGTRECG/MiwXGGNMVVyASvdO2BBhtXRjI4CeU47Qen5Y3S+MNJ3/1unDl6dJ4nSqqVBytDwow44MBSyNfQoUPjgsqT+9hjj+UupZSC8u3GigZlW2glXEGn5OmMdEzAHfQKVuDjOqTyHFu5EfJlhRHMspZdDcJmfeErVox/dNqP8sfwOBbNQ5knfHTw4MF5pUWdVbEQisfJcOx3vhP9KuUSj4bL3sHHJRZfPCiuJb/nEjqhqJ5y6in5iFFKLboRuUAfsdLA6SMvhxE6NOcpteKLeTFPTzzxZAghe2vatHh98uSsS3BS4POPPd46V+qY0Ylepb+TXpwUG224YV7ZgSP4MDjpHx4BTmDj3m+p9r16zC06gKv/vPufeRWGfgYm+AK+rq6mClauU9+a1ra6oz71483a8N5Kh774nVLKtDFl6tTMx+FzSinTh3LaZ9T36N4jHrj//qjX/5rqtWMd1S/IgAHwglhWFT974003ZcQrfXi7/HjniiGYcMSUUsrERMhRJFITwmstQXB16do1UlNT4R+titjss2dEw7hTkr+1YkinbimlFIjTGwiVIkWXpqaMbOrVNkQsAnC++eeLqdOm5npb80f+L6WUDRpCVTnX/KLxpy4hQHG0YoWB8EYQtk1duuR5N6+YvWV6yo4wAsZtSq1zbECEPyFhnilCffsu5nEuT+Cob+CAAbHsMsvk05YIX0oDZR9za+7dOyZVRjBcmVAJccJGX7yDnzwhln15x9BArvydPymld37NiMsn16ZxUtbBm+fJ0vGkSZNCOAXaJDhKa5g84Z/hVa1K9ppzzopu5878Qz280kKXhAAQwL/69a9yyOKj48dn5RX/UZe8rpJn2jc3YC38Qblrr7kmKGPySCl1Xngbr2QcEnyFY37DeyurTptzX5L5wDNdrYaBkXlZYIH5s/PEvMBvThahHAwGSg4+acXYyhAjS1gBJUyssT7wAmobnpvLE048MXzA0HwrX9p3bYr6FpnGAz76KnFKtbS0xI5f+Ursu8++QUGkGHlXUkrv4pHyUnkHxsJQLrjggvytj5WrVUv1g5d8+BHZKR5cau7dnB1r8Pvxin+YJ8aXVXPwpBw3Ve1R/vEvfGSeeebNh4qgIXOApzEWGOg8x0KGS39cU3q3v+5nRDL20i79gQPRqU4MJzwTnhoPWiaXjaHPIn2ytxsfVjald8cBpqVOMKiEdp6rBRZYIBgGcFtSp7zKf1gC88cmPBbjKx7zr5deitGjR+dQGAYIA085MPa9HI5N95K5RneMtxcmvhBC/vCeK664IoSopZRki6ZUPzSAb0x4bELeF8CYvf+++8KHCrtVehc56j0eAaaUeWME59nnmCOP6a23347nX3ghuvfokfGWgwBcvnvSSfk7Nm9OmVJNxds5mVd6nhUHcqHXHHPGvPP8P3v3AejndDcO/PtNiBAjdqwm9moJbYnSV4wqOt5oKa2OqBotSqtUq4hRbd9/9dXxVregZo2glJZKlFhFtBRVxKoRe8/k/3zOda5frliR3Pxucy8nz+85+3zPd5/xLFxkqzlhVNDHzBM5uUyzCoR/gJ128TUOqBonH36DPzFUAFffMjvg7L3dQvvM/CyCTGaGFQCeAQR1zrnnxpprrBEmERJAqJcaq3DK5Mll6c+EQj5PEz9Ho8z96pe/jDPGnBEYQd8+fYsiwItgD6b05ZZbtlHknytIh4EIytd66tDFQaLSbtNeTdf+XP37x4gRWxWF4cgjjyyHLzElCoTtEPqy3rD1Qpv2eUL6zA7Es/xpKxMvh311mH1ts/fZXhDwQRfeDWcV7I21onTP3XeHvafwxrs5hK8MA8YDBWDSg5MKflpGHjt2bFj65mn66Ec+Gpa3bWvDtHxA0PkGXpS+De5u1eAUr7l3B/M22mijsNWNN5GwsZJAaPDiYL7ahI8EWYUchozx8cLWuJ72RHvgq9/G4sAb7xJYnHraaeVaT15Wqzrg/fgTjzc0/XxYApffflYwA3+rfRQsgoKChf6OO+7YQrsf3OyDweNofihaPJTaRPO1fe2iYcbJL3/xi3JgbnjjxWQkWqnAIxh5aF7ZnhqMGdwnN546WzZtufTOSFpg4MAisI2NIIarcJxBQPmylx5Pw8ve8+73hDMgF198cVE8rU5QfGxfsa0PXuN95sfWAoqrj17BeXUPGTIklIHnl44fH6OPPrqs7okzD+YFvDMzllxqSV1q6wCG+qyTlBtwnfTgg2EFcelllilfCJYmUODlAS/vgnkR/AYTH9nrO0ffcmDTtl1KEX4ETzkawJkiZZvuJ7b5RNirD7a2d1z117/Gz37+80I/eIjtuO60p/jaBoxuBgwYUOaaYWIF7owxY0JeKxm/O+V3Zf85WWilqF+/OYORrm+zMoAPOHuC0fjLLivyf8J115UPrsKX4447rjgO8BK4CnZWtOxVh3cU3dYxqEvIzFCf3QJWISnstq5wSNqK/Oijj3YWk1+oEXQChrYVY4aaNPqCpy2V8J4yS3nVf7slallyhexgRFjZ3HnnnWPIssuWD9XieeZb24MGDapFZvnTCs7nd/h86C8HwVKNkg5WYPDM008XOYhXDB4yOOAZ/DMH71tvvYC3Jxx/fFxwwQVhBRe9w1tOt3P/8IdwtmCxxhFrkOiDkcvooGOZW7KXoq8cpwPHkLMlZPOl4y8N71Y80Qu5C7/FMQA5g/TF2RXbXPE0NERG40fabMcw2xsMPCSWrzFORPHp7bcPB0Lta/MVyuUbbyyvASLntULo23ziE8ETTEFC1ITYxhttHLaJWE7deaedy5YByMw7OXTNobHdttuF+nkZIRGk5HW03aAihjj7CdXhQKmDNby4lEgIrq+bfmDTUo9lYsxBXYhDH/SFggep99xzzxg8eHDZk2tpH5PVZ/lqe7PDs6eNkcJJ4FIKrXZt1iyzwqOBAwcGIxYTN98UAh5S889reNuttxWB5WNH8IaA4KWjYFI84Z6550F5R7Pq4Dcmy9hshRFcgW/w7qADDwwKlvaVz8ywLxR9EOa1HIY4zzxzl7Qa19OezmGgb4opOKMVvwnUvb/61eLlQ/vgBmaE7cTGg4cHmCcwAjfbBcFbefTplpctP7RlPNIsmW//6e3D/nn1doUPxdYeV/HoF71qi5CiYH3841sHgYjuGSIUErgif08MhDe+2sH/MgheOG4stlvwVsvjHa7JR5kBE3vswQWcbLMgbPFO+cGdgUDBBB98EC6rR4C/LgzAY+VHAwQ0/Ga82Wtv+w4+Kk4e5Rjftvtb71RYAAAQAElEQVRo33u7hswsB4Q//OEPFyUdzoIHWJEHaBqMav+N3RirApmZQfa5BQ0egyv83uwDm4X58W7VXB2ZHXk5GShUVna22GKLWnV5uuwD/dj2Ap7K4ylkX2bGQgsvVPDaHAvmYOiaa4Y5QJPyi1OZ+bciAVe8z6qgP+ADB9HysHXXjbWGDi0e6y/suGPw4oMpWvXcfbfdi2OBkYRnUzSHNvmvuvKqYlAYR2bGyJEjg7KrTryI/mGVhZNoxIgRxYjFF6QrI5AH+L/f0wrzzzdf0Uv0Fy6YA3yJLoE20EEt57d5pQtZ/YEH++6zTznLgIYuu2x82d5Gwa1lZvXTWNC//lLE9/v614uBAya2X5GDa6y5RriBCo82J2iYXB35uZHBANqqga1vB3H+WKVA+/BO/uWWXS7A+/bbby9jJz/B6T3vfU/A98yOnSDy4v977bVX4D30PfOM5vBtdZjPkc0c42XwXz79tuUOnjBgPOFVtOnfbG8wWGZyZgBTFChbEALyEDiQERNE4AS6Cd1k443LgSyKhTTlKAKuJxs4cGBg0IwHBElhU19lIixMDBPT+fjHPlYMi4ob4kaMGFGEJ0Vwww03LMjKS2nZk4dgzBljwlaTp556MiA2Zk1pUQdhyPhhdEBCY8N0IXEdI+ZDEMjfG9oPAvCL0g934JG54kmGP/DDnFK0pGNQcBBj5/3n4SMQ7A025/AVo8fg4SamBo++uOsXi5Dmsc7MqYBAaBNWylNi1U9hhWeUDjhG+GCoChKC9jC/+93vLUa0uJ4YCFDwIoCMzW9jRYPomyGAhggW9LbGu9YI+5YZDgQDoYAHgJ85ACPCF+0THurY9hPbBqE9LfiYQ8qQNKs3FD71eBdsIcM7tMejCRfMn7SeGOAinAZ3MMfj4HNmBiNt42alC74ZGxw2H2MvGlvOfDHYwBqOUrCkc7AMGzYslIHr5stKjvlQRw0EN8UffzYn+DNYmlfC2zvaUt58oyXbN8CcEZM5Nb3UetvpSWaBB96BfuEVmWDMQ4YMmaqrcBQe2TLEu5mZQWYoD65oH5zAQuB9ZgSYD4oleccJJg+cB8vWBtQtTVlBXv0yb5QmN1lpAz64Ztfcd6U5eGHlgdH2uUbJgy+tbXT3b30FH7DMzFi88bjjmcaHbimkcJQuAR+NiTyGV8YmDr499dRT4YYqNJ2ZQTZXZRGf57xRpzOP5gkua6eVL9gGpR+vBQMKq7lXj6AfeJIy4G0ualn8hWO0vsMdSi5+Z2X51FNPC86i1vZr3nZ5old4qe/wHo9gGBgD2jcexgQ5u9XHtgowIWfxZXNjjvByOMuoMA/0rMuaFSSrmfRAZXYYuUOgM/Azl+bbb7Jbm/Q4baAh9SqDdsBeHPzBY+hr5sg24JNPOSVGNgYFmmoXeHbtx2xvMABIZkZmR/D+VkPmq8tmvjqua72Z2TWq9ONVkS9HYLb2SiLYffbZNwjGl5M6H5lZ6sjMacZlvhLfmaH3R9tBIHPqecp85T0zyxzXThMklAGCTFzm1Ok1zlPIfHW6+BoyXz+95vPMzOLR2WKLzcuhPXH/CSEzO4eRmQXemR1PCgshTrgy1GTM7EjzW8hMjxIys7N8iXgT/2TmNHNRLghEXnZCbpqZ/gMjKZW2cNmfbXiZWWDq97RC5ltLz8zOajKz1J3Z8aQIUNSqMteZsQf9yOwYS9cuU6wYbsPWW6+MuWu698yOspkdzxrnKWS+Eu+9a8jsSM/seNb0zFe/d03L7MiDt1kZ4vyoedrpmdnRz9Y+ZWbna2ZOBV8y3JYtNJyZnflaf2RmKZOZndGZr/zujHyDH5nZWU9mdubOfOW3yMyp37vGcVRt0WUFSZ7pDzO+ZObUY8jMMvbaUmbWn+WZma9Kz+yIy8wi0xjCVvUzc5plSmTLP5k5VZ2SMl8/zmHoz++wQ7Q7fHsNBrM5kwMhP71NtJYluFiu7ihn1bJUp7fe3nI9FwKtOFFHYeWAJ6S+d9eTIB8+fPhU25Gm1b/u6k93tcPzxJvIi9RdbWqHsWLpnTfcb3FvFNp9Pt5M/4yVB5R38I3GO6PTGWiMQ/x3RtfdDvVZ0RrerGaj5Xboz7T6YN43aladppXWNe7N4FPXMrPinbfaLoZZ0fZbbZNTiu6RmW+1aI/Pjz6sts9M+gBfhnu763S9BkODzpaaHEx04OXYY48NS9CV6dgrPmHChHCQxWG5utfTYS+HXRzOcuuGa8vUMXnK5KbGV/5324ZDNg5sORwpxb469WjHu310V155VajTXb7ialDOcnjtT43vjmdvG90HAUu+de7tUYc3V155ZcA98bb+6I3Dobak+Q2P/n799WFp27sgDm65InhK591cUiIcqnIA0t3bcL4j9pV/HapzwM5hazgpRbsOkzpUap+yuNag3+p0GxBvu/wOflVPcGve7vptbGCHPvVPu+jH5QYOwDmghq7FO4eAdm15qHHgVGHkNgz1gLt6lUHHaP6SSy4pt/OIM16wcyhaurgatO2A46mnnhrKgFFNq09zqE78BOzBGt3rB1ywHVGemt+e2so/apyn/sIZlx64ktI2E/OhTukzKqi3tX9ga9z25fowERxyuFJ7zuO4h97BewcnxQlwFG6BKx7poghjld+8qcf4tTPx9tvL3mDltH3jTTd27v8WVwMeqg5l7f+u8a1P84tGzLe50Q84DMfVLa/5NB+2jFS4u9TCPnr4AM7y1YDujM04wV4/zDOc8Kz5puepn3AW/oAHOlOPcywO1NqKCGbijBkO6Ye5EFeDsYJzhY/+SjNP+mwevD/y6KMBv7Sr7/KjJ/OgPDjgUd7BWd9qWeXBwk07ykmHp9qW1jXouz6L91SnvsBdYzIG7+ZHP+VrDfDaeG0ZARf9he94WWu+nvIbzPF78KswQwvewRV+Gh9+BT/RFLz9973/Lpeq9JRxzsh+ghkcq/gGd+FNbcNv29kc6gbHGu8Jp8gAsPUu4L2+hwTW3uEluoPj8ApNu0AAfkpvDfqBP5hDdZpDdAZ/9aE1L13x2gnXBhzWhsPXxtKap91+z/YGAybz81/8vBwMIrzcSmB/LMZlst3kYO8qRcDNJ/aoYWAYmhs03M9uO4hT8ISL7zDUSSaIHJLxdLIeQkuDwE7Mu/HAO+Q899xzyp5oXxnUrngB8jJWEIH33vCfBwECwU1FcMjcE6KjRo0KS9a2QtiLTcGhNLrhCCPCWODPLjvvHG5cqFDBAO1TJUSnTO643lcaJcleVjdn2NpBcVaHNAEjdIBOu9r41re+FZSm//ne90J+B+oPOfSQTqVNGYzOMrXbxezb9DVXTBRjtifaWOTrzoC2KFYOfP/4Jz8O/bv33/cGoWoPqZuO7B2d0DgBCArpaNMBNsoN2OIDaNm8uOBAur2t6JCyBD6Ce9fdRoJG3STjJh6wMG9gU8d9wz9uiJ122jm0DU5uKgGnmg7OLkdQXn1wAX9xZz242+u92WablQ8HKUMomaujjz7a61TBoT3jdODP7SjggXeNGzeuXP88Vea38YKnOTCsHbDTPzyTMvOl3b4Uhx52aOGpxkmA2hfslhi4DI/hnpuiGFCUW+Nxa8hnP/e5wGcJ6IMOPKh8nMq+5C/vuWfAUV02Pw4xtuK9eEr8iBEjYq+vfCX222+/wKfFtwbKP7j+/Oc/L9chogsHbPHdr+39tVKu5nGt5GGHHRZoRpyx2tssr/48/MjDnVUzluAV2jP/blExRkYQZaEz41v8gYYYq2QMWYTeTzjxhMAj7JF3mxpch69wjuyCR+YEHbY2Zwy8mPZTw7GqoDCClNdfeb733e+G21soTOYZbpJzDvCbZ8YQPIX/YAKW4FjbYsiY76/uvXfAX/1Qd02vT3PsLIT24Skasu0W73GrELoCP3AFc+0bYy1PgQMX82kOwQe+UaJnFf+pfZvepzEZu/kz1sqP0ARdhbOIU/Oon/40vr7vvoWnmJutP751oKvpbbcnl4OjcESAO3Q4uGNM6Icza6+99grycrvttgtGr7QqK/FlcBYHT+Er+N99zz1F3pGlzunBLXwFjyVLtaNMDWQ0eYLvOpuATtAF+hSHXvHimn/c2LFhlZr+l5mBlt8Or6j1zsznbG8wsATPOvOswHQgAMK0xQLxmXCKAaFBCSH4MDTIg9FhUISDg0eQDhO2J9SEQdTRo0eHQ32rrLJKufIy85XlvMzmdxMwSgrAMsssXQ44ZzbxKng5OFFvSYwyA5lfju59/IdAAGMjfHnIHMrKzLD9Ab4xSB2+x+QcfCZIHABceKGFgrKIwfTpk537JSmz8vCidF3ahLMPP/JIuT7SlraxDbOqChhQogO4i2FRlHyg6oFJk6JP376F0Y5qDBheRp4Q+QWKnu0aBDRGeu4555Sr6xwCVr+xydedwV7QF196KXzw6OSTTi5K4fU3XF+ulHTYldLvgDEmDeaZGRRVfQYjip+n7V3of/A73lGutEXbxumKWsY7BYZSaHWC8sbLCm4EA0OEYK/jvv++++P9G2xQhLurPSnVlKqazvOkTnOnXodOl1lmmVA/PHBWiSAST4lz2Prmf94ctunUOjylqZfy9NOjjipXLNsy5TAwJZthIt+MCA4R4nmu1yQInemwxYIRsNMXdopzfn9OWdGy0uD2D4YCI/Vda7wrxpw5JhhEvHTGde9995aPRBmXW07+dMEF5UKHU087tQhRc8Fwtt8bbuOrxpqZUw2FweLAoDvU0Qe4tWbgfWbQ6U9mFrpxw5erRo3Fl3gpznAXT7aijMbMz2WXXx7o4YwxY8pVjU88/njcd+99ndUzLuEOZYJB6DYch+c5m9QnvTPzW/hR5QO5gx8wVC75yyUFJ8kV9MrYoojATThOyTYnxtna1DXXXlNuzmMAg49DtVYKGNMOiDYAKXIQTpNfyjqQaV44M8ii3ffYvVxucM+//x3OFKgLb2i9apMhN2DeeYMBgN4oT3iL+mqgXDFEHADO7Ph4qv4zyKz044mZGeaacoY2HJRu5Slgas7J7k9/5tPB8wvmaBnMW/PWdnvC06Fpxi5DzPxnZjM1WbrOeCQT+s89d2z/6U+HucaXzB9DcXbUEeAb3oC20R68xAcADM2jAwebrca5TAZ+8/rv1RgRcK51qyE5SK/z0TVX4lP4GbYOKdvtwel77HHHBcNEvlaeypAzN65jlR+/IyPnmHPOwvu1hx4Y5er60Y9/EvPPN79ulquC0fhJJ5/c6RgpCW32z2xvMECAIUOGlLuTMU/vGI7bMlimTsLzqkAcxOrwy0Ybb9QprFmmmKvQOreQguLBsMjsIPbMjmfN543XgHAaPHhIWVLMFFtzRGAe9itb8ickX0np/fWfAAGKPeHOM0l4GhNFkIClxPhN6cAUKbkORfXp2zfWWXfdYMzOPfc8xXNMUcagKECUK3ijrhp4X1dbddVy1SIlHyPF7HyYBg66yYMnlcCFawvMv0DM1wh9TE5fMMfFFl1sIt22LQAAEABJREFUqlt+3GzjY4dwn9KsDkaPGyMwZN8qqO1317P/XHOF2z/cXEKZocQxuNEQxY9AsZwPBgwHHj2ecgb52u9+d4ATWqcQu+EFTHiWpKuDUUY4qVO6OfO9CgoTryyFWZrr++qY8ROKkHeKnbZdDQnu2uchsw2EYkZJmHfeASGomwAz74xGyj+edPc9d8dmm30w+jWCSJ01mE+GB6X3wAMOKAaHuTEfDD38reZ9u8/MLDcSMVCubRRRwg7uUOjx04EDB4ZzNYwn13BSfHj0PH1UysoCZRScN9t0s2BQ8Kjimcs2/NiHlewZZjC5IYbybx4YUYwpAhleto7jtttvD0okZZgSS+nSHjgrm5mxxZZbhNUi9IF3u7HuG81qhEOolEwCXz/mX2CBmHe++cKtJvYXUx5+cMQRwYDkTJqrX78wh/HyH5xBo5xKjAb91m7FGXB4Oetbehijm13AhwJs/gcPGRz95upXlEjjhePm3a1eX/nqVwOuUp7BtrUxRq05sLrtOlqyznzBaYeJSR78xQpEve0oM0s7lFLzwRjUj0kPPFDurz/8O98pRl0rbumPb8fgX1YgwITsAg/zIC8j/b82/K8Ytt560TRQtlXiXYxpDrrRxxwT+oYeGZYMN1c3L7BAh4IVzR8cg9vGw0BlLOGX5pDB3uoQabL3iP/RK5yzSjimMU7hJD5gXAYAFg7fU0InT+lYQQYHOx/wCXMp3+wSwAs+mW8O3/2/tX/AVfgGBvANzqMNtMT5AC/IKYaolQTx6nno4YfLB+6cV4BDZPNdd95ZnE54DuOC487X050jw285EbQjwFd6o/liXKM3qxn4HB6mXvh8R1Onvm72gQ8UvbMaec7oPNL04cabblJdW4Y+bdmrbuwUxWmeuecup+F5PTAf3g2C/elnng5KEwSg1GOAPB0+JlMRUlchm+B3DQQ0ZYBAEtea7jckwZTVA+EhtHh5WwNGgYEQzOprTev93fMhwLtB8aaUtM4/Bsh7xJBw9zalEr5QRJXxoRmMiNKTmXHttdeWbQQOw8MtiibG2AoheOwdTnle9derYr9GWfr24YeX6yr1gRfztNNPKx9f0hYlUDxDGQ62Kj4UJkosrwkjg2dbvZjjnP3mjAfuf8Brt4bMDPS8YLMKw7NOeacYMRLQokOGnADGcsWVV4QxYOQUJmNg6FCMxBsbmDMECAvbLAga8KshM4PyREmixPKCUjjNXx045dSc2J5IITKnlE6wP+zb3y5bCSigrlXkCbvoorExceIdxYHAg29lgTGGP/HKLrP0MmWMBA9Ftbajz4xI3i9GKI8XJWzgwIHFUDTmmndGPQnnJZdcKgjKWmdmlp8ErnF/cLPNghebYfbXq/4a8JfgpNBmZqOYz1tWIyzdc7RQjs0hOFK8GQt44JlnnVVWLiiGhLX5auWJG/7Xf5XtQzyMg5ZYInjFz/792fG1ffYJKy4U1nXXWTcYd6WDzT/mNzPDHDO0KLjgVeiqSc/MsvJLqYBLVkzIiBFbbTVVPRQMq0NusbPtRz79Vz8agh8xHX+ZWYx0MsLKIPh85tOfiY98+CNly6CVL55T/QVX8mrZ5ZYLPMVHxFrb3WTjTQp8GExLLrlkWVmDp/BcH/UVDoMPXiToMqNk3LhxwXGxwAILlHEbJ7jaImX7jy1+Nb8brUYdfHBwNjB2GMICfLcKR/m/8oorYq2ha5UxMC70HX3YwqSd8ZdeGhQu7aMpTgB79q+77m+iSrBKhcehaatbaMocmz+4x4ArGXvgPxsNHx5WgA5u4MgbDT5kAOV3lcbxg/9UeBse/IQDgvfZJWRmcUxwEHDKfPxjHw/0gI9PDYMOnoR/gxGcJ9PgfGaWrUfkGDnKCH38sceKwXr3PfcUPow+wBtegb16Xpr8UucZttpWlbHSGSvamnOOORqbOMt3lLxbiYfbq6yyStATJ06cGPRQPE55xn+tr92es73BwMt43d//Xg4cE0T2uWFYBNI6710nrrr66rJflEC0VMoqRbSQ4fUmE1LV0L9//5IVYvihLAHAWsXQMTlKjDSIltmB3N6FzCxeZL97w38mBDCS1pHx2GNOG264YYnO7GA4ma/gRi2TmcEzQcE/86wzg5JF0aTklsLNP5RWymPzs3jzMEyC1Yd9BjZKAFw98oc/DMbyvvvsG66So9TZQkNY1fu3eenVIWifQOMtpgxa7hWfmdG3T9/o26yERDf/8bBRTh6cNKnxwm8WtnBZUnY4nCLKoKKAMqj+fOGfY/hGG4XtNJs1Su1l48cXwQHuum18lMBLx48PijoGT2HCGyhuBLh8jH6Ch5JO4XeDEuVFeekUx0MPOywmTJgQVmrACUwJCAqeueHBUj/Fx9zw4jIG/nLJJcHzpH5OCytCVjp5kCmllAltCBQovIkHUj3i9DMzy1zM6PlgDPB42w6hz5kdyj/4RPN31913xYBmtUR/bNHBOymQVmgIRjjXZCvGKmVS/6wgMITF867O1fBOW/QI6wfuvz/mGTBPWd6X5kwE2Mor8ObpBwNrxRVWKKtFc/WbK+D3fAMGdK4Ky1sDQc0JZBy//s2vi6KtjhdfeKFsI8WrzYP54hU0Dnv3eYArnugbBcB8a9t4MzuUEO0YVx2r97caeC6dI4IDjEArOJwIDEN7+EeOHFm+nYA2jzn22DD2T22/ffzrlluCsl/bQwdwbaWVVgr9rLCjbNY8xmIcre9oxVgZ4OKVI7estsBZ8wlfpSnLCKEkDRk8OBgg5JuVHvhuDHD0qaefjqOO+mlc08hX2+UY9foKdlZlzIG+MIIZDNpetFnhbFUEGaGMuB122CGsqqIFClhmzhR8j276A8Ps0yds5RoyZEjgweKsHDGEjRnt1XkDJ7xloYUXDvPbTd1si2bAxfZZT04fhjJ44Mk6iO76z90/nnv+Wa/BiMzM4iAWoZw8HA/333dfUeyPOeaYcv7pjDFnxDPPPlPiMjM4zshEPMOTETFo0OKqKQHOolUv9Dt8jGEOr9EA/o0GMrPI4B/+6IelHWck5FFOmPziix5tGfq0Za+6sVMY1DrvfW8cPOrgOOqnR4UtFlYSMGTLTpbaDxp1UPHMSKNAEO7VCMjMglBdu7zwIgsXTxohDrEgMs8Ko4OX5faJt5evOhJ8PJ8LDBxYmBwPJCVMsJQLoTFYbRJaXdvpff/PgEDmK3hEGFA4KZYUVCMkJAjl+x+432sJmR1l4Mjw4cNj9OjR8YMjfhAUY/f0E7y8pvY5M3gxS9t0nNOhMKz/vvWDZ8bKAEFrywWvL4+hrTuZWT4sBF+POuqociuNJV17Qh2YVLctNAwP26F4aHQMvmKqiy22qNduDVOaZXp7tW0louDpJyNhraFDy7kPzFmc8TMcxo0dG/LxXhobwx2ceS7tRUXvCy24YDmIS0GlHKF9Wyp4RNEu2Bvv8b/9bbm4ACx5WcH5D+edF+B18kknxYqNogZelGJKG4WPV50SrTxl0HYaY0DvVgReaoQHjxcgUsx/f/bZRYFgmGy77bblC9QXXXRR6CsFgsFn7Dzq+sbzbT4o8camnhkVbr/99qBMV+MkM2PLLbYs52SO+MEP4v777o/NP7h5jG1gfOpppwWFFuzNBy/2rbfdGgSpVS1jsI3MfnQeQoYf3rnC8suXPfOEOkWdwSWPrTOMDELaSpy8t956W4gDXzjvALRVG8be53fcMfDhrmOnqP72+OOLF/+E408o5z4oHmBJceBAUg6NqYfAt7JhvzQcsRJtTzTDzHm20aNHxwknnhgUBbgCl8DI765tv5l3BovxUfa1rV1j0wdwgGtwl7MLLH78ox+V1RKrIBRtZRjQtqvAJwYP+MAX+F+dVvCjtT+ZHbwFLlKO8B9wkEdeqzfGKjAG4Lt6xzZzTan/n//5Xtkaoo/kKFyF71ZJwPG3x/82OChsSbKdRv0UYzLWHOOBDEWGAppxvoShggbgijHrv77hO+jRvFHq4Dv8Uaf+vjq0d0xmFscFHLTiZV7hmu1I71x99ejbp0/Zjnh+w1vwZqs9vz/nnPja3nt3KsLtPcIZ2zuXWji/YbXTuRm8na7EEQBnOH45h+AIncqKFIdF7QXaZmjZCkcWgLk8Pvi2fLNaJx38yVO8/8j/PTLwhg3W3yA4JNAnesRrOHPITkawa6CHNnIH3ZEd8NQWdZdYuGiHvsmg5qDGLx5+6OGy/WmFFVesXWu752xvMPBg7Pv1feOTn/pkvPjSi+XQpqWt7bbbrizjH/Ctb4V9m7xEkJCXzGl8iGM27dMlvHlOvNcwd/+5Y/jw4YGBYqjbfGKb2GuvvcJv24+++Y1vFi8Poc4Lmk1BgtQhQFs6BEhMEF03YUJRDGqbTdbe///DIEC4YyaGlZlhuZSx6l2gyDMgzvvDeV5LIBwxH8Yt3PSkFFodgFPwhaLC6GAYU3AxP8pFxe9SUfMPxYKypQ8ElHIChZnSqX7MWD/QjDp50t3QQYjLK079FEkK74AB8zY1d+//+v7lPb4cFA3KhO0XGPmOn/98UDL1zWqCODAAP96djZqVhpEjRwb4gaPVGSs29nqvt956RaGkMBkjOpZGSQIz8GF0zTHnnGWJ+itf/UqsutqqZf/7AvPPH0OGDCmK7KrNErQ6BB7EChnppXyzdK3/6idAwNd+8qr4EHLmXB+tirg9yLzok0CgEZJ4lbZGjRpVlsHvuOOOoKAz7GqbM+Jpzm3T0p9an20UYNm3b58ggOEBxW71VVcNBiuFFW5zoDAozAehynCyN1gf8b3MLCsrjN9at3gwwTOteDG6eL7hbv9mJeILX9ixfLmVgo52hFq29Wl7lz6Bp3n8SsOX4Qu8NiYwJgPUqW5zQLE2L9s1ckE+8O7TKG76KwwfPjwobzzvYA+vzCVFXV5009qHN/s7M4tjCX6YQ/0ja967zjrlBjB4Ct62QYHpkUceWbZQ2LJou9KAZkXGGOAJ2aVfvJ+2+Lisw/zonwP+jIPMDKvu6AN89BPfkR88vIMfpcpv9TICKOvoBmysiu688y5l5Qhf0yacl19Qj/NQttbtussuZRWCHGUwUJL113jNg6dxmWeGhnlQFzjop9u4GJ1oEK32bVY14ZRxyae9nhTAnKLJyIJfcN2c2jZpnuEtGLldh6FljBRkfBgO9qSxzoi+gtGmm2wa+JCVLefKnEugP+GbcI1MEx5+5OHAZ+BnJo0ripzwDqZwCn/BR63uWCEYPHhIMcKsssFHK+kLLbxQKWd1T/t4CJqkv6EFRr4VL3IRvuIlmVnO1uFb8sL/JZZYInbeeefgzNP+eeefV5wjK6+y8owAzUypoy0Nhpky0tepdNFFFi2TCekYAxQuQkARSMQgEG/ibTvA0KQJGCWEQ+jea4BIBJZtC7xYTsMT8IQPBooBQBIWJsGnHEWOgiOPgEFY6n6uWR4nIDBD+XrDfxYEMjMo9JQWI4M7fsMN7wKBaendTUUUQHFwFD56eheUJfWz5n8AABAASURBVGwI0MwsyoZ6xFPU4JXtFK1KnnKEDrwUah4KGoGFeVI2MEA4SAkQCGxKFLpRhjLFo+qwKe/ggAEDVN3twdiMUb8IVkJjkUUXDXGECeUHDaNZircxY/CEDAEMTpb/KTH2w0s3PvSsLoYCbzeBgf7BBO16V/+wdYfFHH3nCMKdsSFN+VoPfsKQqIAxN2CpvKBdcRREMNWnmtczM4MSRTjWts0xfoKvGLcVJgKPwwHO8Jh1rUddbycQrrxjlMRaD1wEyz1236MoguLNx6c/85ki1MFEP1dpjCc8zda5Dd7//nIQWb/xWQYdoQp25kIdrUFaxS8KK0FtFUY/wMu1rub1tfAPXKwmoSn9MC/aNkeMRnhvjs2F+USbxkC4y6uPfoMnmgBbuKTf6mHkaIPiYLWE8U6Zbh3Dm/0NVsZK9qhb2+QC/IFH6BI+U1oyM8gi+cw/pXmuufoHBRSeGhf4SMc3vJNv4AzfrXJlZuAd4sAHHjIQjNO7fnviT+AjMCjkY2TgC+pEd2CHZ4GdctMKDB08JjPDnJiDHZvVIDxMnQxnStZuX9qt4BN814b++D18w+EBJsarnsp/wOG15n9a/WiXOLBF2/A5MwNewW/0Tek1p3AC/I1bMAfrv+99RbFtl3F0Zz9se4R74IAvwxn83aoWJR9fp3uhXXgJprV/8IzCDtdqnLL4FPrAz/BUOhz64NxQDxqn8LfyH3WoHw6PGDEi8CnziX6V4QxWX23H05zqr+2WF1x4YezQOLboitLaMfRpx07Nqj5hQCZ9Wu2/Xtq08ovjVeIVgRDeha71TKu9zCzbnDIzKA17fvnLMWTwYMV7w2wMAUrlAQceWBjRWwFDZnZm74p/nQkv/8jMTtx7Oars/Vauvnd9Zr5SBgOlRGKSL+N21+zd8q7trn3OzOJxz8yp+kAAZ3bEKUNYUDgxexkz81UwkU8b0msQJ9R3z8z0KCEzX1VPSXj5H2WFl1+n+6GO2jfC0VgoHeKnu9K3UDAzo2tb+tMaB7Z77blnbLHllgW/ovnLfH34NFmm+X9mThXPWMucOm6qDNN4ycxXzY3+6ndr9sxX58vMzixwqZbJzKAwc0DVuM6M0/EjM1/VR+1l5lS16XfmK3GZr/yWsbWM3/pnW5zf0t9s0I4wrfyZ06a1aeVtjVOf0BqXma/Cp2j5k7/CF/+hKM5q/tPSvRnyMzPL3HetLHPa8V3z/ae/Z74a3zKzc9iZTXrjxOmMeJM/8Cm0wQDwWzH4lvlK3eJaQ9f0zCz4m/naZZzV2neffeIDm246zXmONvnrNRiaibAUaynZUm3zWv53aMb+0PLy8j+2E1kx4OGdOHFiWAJzWObl5M4Hr5589lGyVi1LSVRenZ7ebZnwbp8db5Q4QTl128epLK+C+N7QcyFgzu2ttWWndRTwjldMvK0xtm0IfvNowE17huGJ37Y78HzAkdZ61CGIkw9O2WYAj1pxS7q+wHXtwFO4Lr5r0K69mzXeu+V+eKuOGu+3+jwJbEu6vCvSbQ9BK9L1Sx+1abzSZ2YAA/0FS7SkLe2jX3Fd++AdnI2TJ6iWMQ/GrCx4gpt39RsTenegbVrjkg4G2jTX+jCtoA7ttqbhLRVu5kj92vYUX/unTG3HnOubuVCf37zo3eltBUe4DvbGrm/6aPxwAYz13YqAA7r3/vvfoZ/i5NN34wR3MHCQUAAD6TWAgTnxDsfNDTiDpbjWgF7ATb3K1bZqHnXDCemetrnI493cdq0TXShjbPBAnX7X+jwpGLzFb1URV/bNBO2DM3jLD9bgqy81Tj/FGYfxyGds3j3BRR22JVF0aroLEuy9Bldxns4m3HnnneVGF3GtwTxU+OpHbb81j9/6VmGpTu1Ma27hLnxRpjXos34JfhuTsYCFfPiP1aHKf8T1pACHjNv4/dZ3dAC+3ut4zRkYmFvP1vzKzI4BDsA9cDJ+uP96OAnO4If34DnKwE30jpeAtTj0Sx4wSrUBX+FcTZenBnXiQbUf+mJuxOEr3uVFd+K0o214a2WupsvTjqHXYGhmxSTbP+nQGibWRJVrKu1J9bsGiPX1/fYLe7lrfge9MK6aR3k3mLh1w9YM+w9rOuR1mBnCyecgjDMODo5B3FoHBFOvqyBrXO+z50KA0uNGGwcAMZw6EgzNnsizzj673Jrw69/8JuAL/LIVBv4oO2bMmHDoETMhYOGew1WVYcFLB60cwFT3xDsmxvePOCKcP4BvDgnWvNJtc3P9pgPQR/30p2GftfjWgLk5gOhAp3i462CZOGVdP0cpmDJ5clx7zTXhOkR9k7cGeK59+fVFOmURvmOUNd/MeBKi6Fe72ncoFhN3aFS8cbiJqrVtQthtNA4Ou5xAOriNGzcuLhp7UdTD1A4V24vvQCzGj1bNGRiYp9Y69UN90s01uLam+03hVJdDe94FCoJD0PqhD/bQuvrzyCOPDGdRnA/QX3kFNwQdfPDBoW/agjvq1TbBJE93BDgKn8BZX4yZEaMP+lzjHRLE5+Cg+ZBvwoQJZf+9224cfAWDY449ptxQZaXWQUPC1TjgEXjjteI8Rx08qozfgVyKqXwC/usAOrigHQf0tS1NAF+HsZ35QEfwE6461G+vPrw3F/pjfMYCfxziVt4FBQ5uwwXv3RGM2QF5PMVY0BoYwnd9Y6yhWelgDn4OYuq/foMHuQe/KvwvufSScgbHgWg0Ax7ykVVgoX51VVjUcVKywEya+cQz8K2aXp/41H6N/MQL9d92Le/6q53KG2u/1FnL1qd88BwNoBdzqz1jM481X099gptLV9AOuJovPMVlDebBnJp3tPCt/fcvFyDAazgKB3rquN9uv8lSB/1dzlHk0pQpBTZ4DpyEK2Bb22H8wlf8Ef7bkgfeDiaDJxyjw8EptwCSwQw3c6NO6T78WevzhN/oxlyom4xTp8tuxOEldDr4jYa0jS7JF7IJbydX1dVt4S021GswNAAjjCGMiXNLURNV7se1b83vGgiE6xqhZu+oPaz2hrrBgUCseSgEbkWxlQhxY84QWDqEs58Yg4ewN998UzkYSZkRJ49gP6p9d8efcEIjQMX0hp4KAYLRrSaYDMZPABgLnMD0Mf+Jt99etsqM+O//Lt8/sDcSHnnCIcaBfcATJ04MRu2xjRI1aVLHNw4mTZoUmBOFk5Kj/usmXBfukXb2wB5wt6RQsLSLAWJaTzz5ZMDjrbfZJhy6lVYD3MS8CGx1ioe3BL090/aF+o0BP/HUU/HzX/wi3NLx9DPPyNoZGDDK2Vuqn5QOK26YKGarL52ZZ/APhjil2T5qnmwwdEPGny+6KOx3RmNH/eyocktPbfq6664LCr79rvZ6O9eBLimjzjmttupq5aCpPa2Es33qlEdt2faz7LLLhkPHxlfrpMxQXnfZdddyrzyFp6Z5UkIJOfPHsyXu0ccejd8c/ZtyxS1lFK5YZbRX3d5zfZKvelHhGFibe3tljQ3O8RrLY9wUK2VmdjCnDAYHDvFIQpQyDg7w1/55WzS9M3IotvYdWwFx2wiliKDm1cvMOPmkk8OWAOMmZPFqeHfyKacExZ+nTxtwfP33rV/OqeCn48eP77yKmjA2//Yqm1dnCqzSVVioD57i2dIdJuXtw8edT7AvWZ/QItqghDNo1JuZYRVYm4ygWufMfqIfCgcZ5apd882ABHOeULQG18EYDcAfhhSl3LjghnGTTw6qo8ujf3N0+cosRX699dYr/EEZhpyrmjccPjxs94HvrWMFf/Bz6Bb8bAeyFa4VBtqiuP3u1FPD3fbm/Uc//nGArf3n+Anagz/6p92uH7CC54xmZ4KcYeBwg/P4JByrdNHabk/7jdbpEwxXNGJ8eCd+I41CiUbwiiWXWqocmjV/+BBlV/6eNua3218KOHiRWfgDGKAFeAoX4aQzLRUn4dGZZ54Z6BltODOGruEd59rIkSPD+TByEi+/8M8XlsswGABkNrlJNsBF9FT77zwWPqBOBgzD2zs5ZJsumtNPjqhLLr20fNcEnfm6sz4PHjI4jh59dLmNsNbZbs/Z3mCAPJiu/eEEcmVCmdm5tzZa/ggyAhkDJhQxQnXULAQ8w8BBZkhQl3lren3/5y23RP/+c5fDrhhBTffUBqXEHdWQWlxv6JkQgAMUEUyEYoHZG8kFF14QmIbDU77SDC9sHaGEYjL2Pi+33HLh+kDGo4OXzz3/fGy++eax5ZYfKoakul986aXAdOxDpihkZtivzkCB0/LAL2nahasE0hWXXx7f+OY3y3Whma/eW+kwFiYHl5VzwBVe8rZgpA5xej+tUQAeevihwmC1JW8NzvAYL0bM8CDYKYa2LFEwGOA174x+ahuz147+olUfOnMTj8OVhMQ1V19TFKTaNmeBW2e+ffi3C1wsE6NnAmnVVVcNY7bdgeAwV25dMleMuWHDhpUPLVGKCZ9aJ4XMtpSha65ZvgsBfuagpoOZQ5wOCpsn8ZNfmhzveue7wi033uUhbBzQ0ycrBw6CMoSkm1vlecbqYUlt2BJjHvG3ajDKPzMDPAYXRpk5ZzxQRin2YG7uHU69/obrY4kllwjeZf0Hx8UWXzwYUPoLd43Z6g2l0ljxWmMigOGveIaQMvAMzzQ/eDNFGQyM9aGHH45/3Xprue7UCjGlAu5KE+C4eUZrbuVxfeXcc89d4M9Qufnmm4th6ZCz/AwK9GZevDOA4BslxPvMDpTFE048oRiv4EHJNl7jhyNwkfL9/g02KB+vA3d4A87wAKzNA75khcG4lOc4oACZQwr5lltuWW4HGztuXJGFwzfcMIYOHRrGSuGv+EqhveVf/4qjfvazcMYK/qujFQ5VeWL8gT0j49nGwQC+Dk1nnwx16p/779ccumYjHzu+X1TrUU7bcApd67/xGwuahGM1b099wim8dnhjnPFKo6H+/ft37mtn+DqEbj59nNJv843+8Vk8r6eOfXr7DQ85A6zKo1vvaBw+uUoVP4dv8F8beAZ8Z0BQ+h94YFKss866wckAn1ytin7gpueDDz4U9Dm8vM4N+r/zrrvi3vvuU2UJjDkGCnzG06+48spgbLsmFT059Iz2fBPIddHo0kUJzzz9dPleyoj/HhH/vPmfMbFxDJYK2/Cf2d5gIGx4azKz3J2NEV133YRpTlVmBiXHUjjvLaWM9QqZagEfEeGB5aGqcZkdChlExhAwU0ob5uu3+MyOPLUMwQ/Br7zqyhrV++yBEMCAePkxEfOZ2SEYTzj+hNh5p50KzlGECH3Dg4uUH2Xkp8BSSNSzWqO0UlbgFpyRf4lBg4onECODW+IoV4QrbzaFgCEMJ6VlZgwZMqTcCvblPfYICqxtGlbYfDPAk2KM8Q0cOLB4adUrqBMDpEATYhikJdov7PiFGLjggvHcs8+W/NqRv/aRN9KYjAG+Mxx4A8XJO6ODtsEzM4PySSEUKDw8cZRUggTcM1+hO14jNylt/6ntwzjlofww2ChV+mm1gGAmMMB0/oKuAAAQAElEQVTZGMAlM8uNJow/AkleAQyk+238+AcP0/l//GPZZkbAWak0f/IIFGw34TAelRcnGJMVKco0xVicAE/MmXRervGNd53STqlQhzyMDM+ZHTKzHMrHVwnMRtMpe94JdF5v948f99vj4rFHHwt3mBPa199wQzEUCE64ZRxgDl6UQitz5oxSxIiwmmB8DDXzKo5BePh3Dg/bEmw/aB3n3I3C5ZaZz++wQ2Nsb1lWgS644MLgTWQkmGNK18iRI8sKhe1FjEd09uCDDxZcMM+PPf5Y8TQywtAGPNMOnKbI8gLXOPGvDm8/hkJvjpcYtESgUU4EfYMnmR24DN8YS/pvJcXqgBUoq0/mJTPL9Y3yoWMKOKVfHfBEPJzK7KiPElrfM7OZ0gzt1rGijeGNMbHTF74Qw9Zdt1wva0XmTxdcUL5BwtNrNchNT2gfDViNI+P2+speYcvGdc2qKHq0pWqlFVcKq0XGZX4r1Hht0QtFkCKnXX1GL+YDbde8PfmZmcX7TOnkNMBz0IK5Iw8YhX369m2cRlM6h4kGwMK8d0bOJj/wCo40vAIMDBvuU/jxjBVXWLFsz0XL0uAyPL+uWVFeZ5114oZ/XB/nnntOwWtx9Dlw/sUvfxH0tDkaWGsDXzcPmVkOMYM1nI3mDy3gW/hZ81p2DMBd6T5imJkljnxgKKMx+TKzyEx14Wfwm7yU1o6hTzt2qjv7BDFYfZiNiaIEXHTR2DKJmTlVV5AnIfypT34yLKMTYj6aUpFE5meefqYITEIEQ0PsCF3aAw88UJAGwt5z992NVbvOVEQvTw3yQMJnGuuzxvU+ey4EMBPz2bdP37jlX7cEb5gtcPamXn31X+O2228ruOCdcUGwGi0mBef8FtRRmaJ3wXut3zvBaul09OjRcfDBBwcFR7yQmcE7ztvB24ep8q6OHTs2rBYQ9JicvOr1JLhtayHAGCBWPxjWdQvJRWMviquuuCIoJrUsxYYiwAtsGXajjTYKio760Iu6jcX7jA5gAY7DGy+dLULGSommpFjpwawZYTzRfmtfX8TxjLs+VVleKvDXX/QoH+VKGV7NzAyCmkIFRgQS5RQPkVewosI4Uv/DDz1UtiBe97frGlj9LsBcOfmke7YGQqT1nZLESOOVIrha0yY1iq0tKr879XflmkkKsD7DHc/aTmuZmfEb7K3oEJb2WIO3cYKXrRNPPflUvGOZdwSj1XiuvOqqwE+dHaHUogvwFfSP4n7kkUcW5dh2OGVun3h7+UIq+mG88cIyinlbtW8Fw7wYtzrw4Y98+MMxYsSI+OR22xVl2RzYenPGmDFx6223lXvVKRfy8PxNnDgxLmgUXqvJ+DyF4aorr1JdkQ3wt7y8/A9BD1emNY8vZ5khDwYVI9g5JYaN7YyX/OUv0advn+LM0j5503eOOUo/bePiOLAVzEoXXO3bt2+RQ1avwdcWC3upzzn33OLpVAc6NofGZFUO/qBp8PWcf775ioJlUJR1NPOhD32obPdDL1dffXWc2cAWfMGRQXLRRRcVA+LKhleo2/YpeAB2jPVHH3ss8B8GnHk1LrJZG4JxU+jwIHvF8SDnXeCKNhki8vX0AMb955orfOjOHHHKGCNHw0ILL1yMVviXmWWo8lsFw3cYgCVyNvwHHOqw4RS8xhdsMRUP9z3hNziRfXgSz75VO/HrrPPesIVWuZtuvCkYFpOnTC64jgfg5WiC86B//7ka/j9/+MvMYJzbCuVdvkUXWSQWboLf6Id8mHfAgLJSjUbNIZzt06dP0RmVE9CeZzuG2d5gwHQJVwzz61//erkPnNfp/ka5x7jspRQsN/Ogmvj3vPe95aNCvGYYVevEDmo8vpgjhmgbAwbPg8vDQvBQ1iCusPQyyxSmrh3KlHZ4NQnNgqiTJwclp7X+3t89EwKYA0aAqa291trlo1ZWC3jZllxyqfAhF3uir7n22rK9h4AwUp5jTAgz8y5gWK3KpDR4Kaifsuwg17LLLVsME4Lakj3Bw5iwN9Z+YgcFbRWwXGprlBUzW10oudpRn7YoGEstvVQwLCjehDaGSxF3foI30HYSe4u1r06KHU8NBdcyuiVgtKGvjGh0o17tzOiAAfM4/+PGG+Oqv/41rv/734uSiM4oImCOvtYdNqx4imp/xzQKjjMi6N+2FIYb+IMZOOgnBYsxJ3hHn4QNg8pZBJ5/wgqMH3v88VDH2MYYo5xawWG8fWyrj8UhBx8SjBNwVE+Ftd81gCXlrL5f13hhzTvlqsbhS2B8ysknxw9/9KMYMnhIgL1tO/LiReqmNNcyM/OpzxR5+AdWl15ySVFwJk6cWOaCRw/vs0piK5sPHRnDpc2qyJJLLlmEKVqRhyFgJZfnHj3goTyHo0aNCh/CZPAxDij15pXApoAqbx4YLuZUPbZ38CKaF3Vv3BiwVooPPOCAWHGFFYJRS7nWd15FfWHwfvd734vLLr+8KNLiKuzgg7F61959991bcAzuiZtZgSHESbXLzrvE2u9eu3xodKWVV4413rVGOAeApj1teaCoH3rYYTHf/POXG/0o42gbPoABBcaHrOCmtEUaZXRIs/poXGjC+P3esFk9MC4rQ+f/8fzyQTZwR9dohdPNgWh8xuoPY5bH10dP9//mN8McOqRsi9PSSy0VVr3go5Wgeeaep8y5uYMbjEOrfL4FIZ9tnOZR3VZJGUJ+X3H5FaFPjBXKF3punZ/ooX/4o/l5plmtNXbzc8M//hF4pnHjqZwAaJtBdcwxxwSYnXjSScHgldZDh/62uw0mZCwYMqDAjhMCPeAblHX8wAoVWYVWrLB7WuGF53QvecAaDvL6x5Qo5wo4JODZ8b89PuD5qqusGgvMv0BxLOAZ5CiaO/2M02PcuHFhi+C73vnO4GTCd+h3jHY6oP5ZcbXlkiECd+mM+EqVLW8bIDOhgtneYIBcI0aMKAfXTJQDcQwIhMcgwEwFAqlfY/XbPoDZvdZcQAZWI88A5nvED44IXhJL5ZACY6Uk8NbON++8xbJUhvcEokJuCqL3OfvNGfrwWm31xr8uBNoq0bI5vJpjzjmKgMQ44MDmm28eH9xss+J5xize8+53B2FcO2/bAYWJcBdHyeYBhVuZKaoITsvUFElMkwClkN19190BdylujBFPDJU3kNejKPvrr18UV4oxhV4/CWIVM3jVq83PfPoz4QNbyjA+rLANHTo0MEnbPdCQ8aEnK3UYq1shVlhxhXJzDYbMc0MYUh4p2hRr7czooP/l40+rrx6Hf/vb8cijj5atJmiJIumAMSbtAzuUvRtuuD7AhwLJS2dVwtiMiWec0m7M+omGCQIKrHdzxXCizBqbOswBb+BjTbsOQ4Ohs1G20Xin9OE1FN3MjjkknLSlzhoYPbamgb+4AfMOKOdTCD/vgn21DJbMDHvWKW/4CCWLsqcfiy66WAjyz+zAEOTZ03dKOgXVyoBx8LhxmuB7jOXhGw4P21hss3K1KqcNuCjL6LmrWYW11cdcUUwd7DVf71773QXveLQ/+MEPlj31+Pa4seOCAgW/0Zc68FF4DO7HHffbUId5pzDAdwHcKbUOt+PTyjsHdHCzOndHY+gc/ZvfxH//93+Xs0LgB7/MqbLen332mYDT8N/7zAxkByMU3W280cYxYqutYuWVVipbDLVvlcnZELjG0KWwTGqcXxQW9A++aJwRBS4+/MVpRkY5A0NJBwsrBGQeLze+YjvTdY3BetKJJ4WzTWDGu3/DDTcUGQVeDt3aUmkvOeVq8cZ5BkbqZAwIH/7IR4qzzRzz8JJ3FCf8hJFjXMaBL6I/RgLao3ThGaNGHRQMjXP/cG4cdNBBxRjlCMjMoGDPTNh3R934innBZzIz8FZGl3fGEUMXP4C/mdmsVJ5atjZyPuBDmR38pDv62m5tUO7RPfjQ0xhQnLVWitH8wAUXDFtN7fSwsgDX8CP50beV2x12+Hzg1WSxMgw0ijx6gcccSuedf1488vAjYVV0ypQpxZHGMbNds3qJJ/36V78uZ1PVpzw8RmPm7ytf+UpxCMrLQaFvVtqkXXnFlfH8C88H3tJusK39me0NBnsmbZeoAMHgDjzwwPjsZz4TbsIgYARKBE+U684gTs3f9SltcOOlIagJN0LRkrA6HLChOEEICENhgig8BNJ5KSGROng4t9/+07Pt1xu7wrWnvxO6PIMUqNaxUK7gAqYF9+AZwVjzEMzKUAAxJwoDRghnlZGPAqMOW4wYupRlCgLPrSehrx5L+QQPA5U3XBoF97UMYIoTIaQNeWwxUcbNYBTvzA7hBKf32nPPIrwp3LzGjCFlvv//vh/KUB4ZJTxlPDwUSH1V98wI6IpxTrngPca4CWNeJ3RGOVpw4MByqHOfffYtKwEUeHCR7rpH/aesKksxd8CcoCFcwFy/eVPdHFNXCHm9KWWMJcoueOAn6Fud+qBc18D7qp7WeEafVc9ahlJGqcY3aj5zqz8UOoaCOdd/QoihY3vlJpts3Ixzvlpkpj/hmJuE9MVKlndGkvnQx8MaI04cGFIU4QchTcnkaXaIn6JPEbZaZg7PPvvsIHQZaAaQkeXQL2Gc2aFY2SJnWxxFFMxshwMveIZmGHV48SabbBKZqZoSMrMoscqaR/NgXiluVnzFgSfaU0CalTg3qXi/5ZZ/NR7I54KS4r27AngxiOEpHgEXwOrQQw4NNEmJtFJgHuBEpXW0Cb4cW7z55oShxaDOzGIY8XyKd0tUZoY0XlUwxLPwHvXvtddeoX1GITiZI4ZB5ivwrfDIzHCOhFIlbvjw4YU3WPn0Gz6Iz8xy1kT94nxIUf1wY8sttgx9MI+MCsa5FU8yFf0q35MDHLMdhjJr7MZs7CNHjiwKKp7AKN/+U58K84N2HNLdbtttX3VIvCfDYXr6zpGDD6J9AdzgPc8+I1uc1cnhDd7hoc6HoBdGNl4N3lbalaGrkcdwinFmFZdDCM6Bu9U3vAjdMSzMF5rAr/F6PB/vx3vgsTLkL7qUD49BL/Q9DkBGiZWJbbbepjgUp2f83VGmT3c0Mju1AYFGNN6oeeebL3j4pmfskAdj+PCHPjQ9xXvL/AdBgDeZd5SQmF58aidwYLoYOwbeTv16rb4QLAyxBRrj4qUXX3ytbG0Zz8P8vvetFwRkW3ZwGp0itCm0lHGrYdPI0lZRjPjMLCsQlIG26tw0OkNpsvWCsUHZnkaWHhWFJ3JEMEIo2z2q87NzZ3vI2Cn8VkOtXnAAz6xuP/H4450rD5mvNrZnVrtvtd5eg+GtQuwN8mdmrP7Od8ZGjRXLE/UG2aeZzKrlceQlnWaG3sjZBgK8ERQoXju/e/rAeZYJd56znjCWzCxX6tkKwGjrCX2ufQRrK0Q9Bda13xRAqwM9QQHPzLB6Z+vg9PL7Ou7ueloBI184I7qrzZnVDoXOtrTll19+ZjXRW+9sDIHMLOdIrR7CtZkFCoej7RJod52v12B4GQN4PoWXX4P3xZI+q9KTJ6mma0VQ9wAAEABJREFUvdGzb58+5YrFzOzMak+cejojXueHA2n2xGl7WtksJTucw7siXT5166OntsQL0uzZU6f3Nxl6s81iCNS51A2GAmUkswOfeF5t7TG30gVnEuzl9VtQ3kqV39MKcF2YVpo4db9WOvzTnnzoxF5xffL+RqGO5Y3yzYp0tGPcXdvm9WYsZHbAX7pxOzugjHcBvKdVHmzQc6VXeacV0K15m1ZajZOuLqsHNe61nmA9M4Xca7X7ZuKds6k4NK38+BU8a00zbrxMnPGjAb+nFZxJeT14u4wCvKdVtmuctpxJm9bcystrD9Z+t1vQZ2fi4GbtW2YW+QSva9xrPcGxnp8yXxX+08ovDV1MK02cusy739MKytc5e/TRR8vh/Wnla43LfPNjaS03s3+DN5x5rXaMryv+wWfnNZQBJ/ju97QCWKKRaaWJg7Pm3e83CtrSboX9G+Vv53S8Fs7XPoJBK4+u8fX5WnNE9uG18sFpc+EpDrzMr7SuQdvmRvmapoz57gpfdFVxwFyag1qmXZ992rVj3dkvE2z/p73fdQLt/XS+4eZ/3hzf+e5344FJk8qNRrVfkKDrb3ECpJHmKYhzC4V9l+IF8YLfrQEi2jcrv3RlIZqnIM6pfvvkILB3iOYWCgdo7L1TvtYp3UE0+0Rfj3Bq/t7nrIcAHHQQdLfddy/307f2yF7KXXfdNRxM3HPPPYMQx2zsqXTOQV6KlltqXD3ovWtwhbDDjm6I6JrmnTKFHuC/9xrgn33e9nnay+9AGQZtL6aDi/C05u1JT+NyGM5hzq4wwRvAynh32GGHcq6JMHBY0757ShcacyjX1jH5W8f+9+v/Xq7pM2f2vTtc2prut/rA1VkEwkicALbmALytFNhKYr+yPdujR48O8y7fG4f2yQFH3FwCHvZlu5mrdczGZE8xXgzmDiXiW4xh+4InPTgpTjzpxIL/zj/Yh0zRqiOEu6MOHhXmyhkct5aY35quLofe0Y+94nglPlrTHfTVtvIOLTq7wDB0tgXd1Hw94UkZgrvGAPe6wsJZIt5587DLLruUb7K0jgtvcfCbXLHXGlxcz+qwsbprXoq+uZFmztAGmqjp5pRc0g9wB3M4X9MpY+pU/pOf+mT5gBY6cv7E7Wo1X094wm837IAn2MOjm26+KSoOomm8HSzc9OXsiDIUSvvr4drZvz87pKMR++MduK1jx9tdPGFfPH6FB5MXNV396kQbYO0slbpruqto9U2/rPTyasMD59Lcglfz9bQn+NKLwMT5UWM29grHsWPHdupv8pKVzu+YI+dw4Lgxw1u8HNzvvueesq0c3ZBxdDPn4fBi9KROZWpgAPjWCDpRJ57FcKObmS/nFvQNj8LXnbdQF3pBa87VmZ9aXzs+Z3uDAfK44sotDBMmTCj3QJsok+92Gkhy7TXXxHl/+EM5oIW5EVAUN4QqHaG5IvDyy68oV2w5iORjQw7sOXA26YFJ4dCfpWAW79hxY8PBGgdu1Ke9GjAHCoFlbkwV8qqPIHNrCIagPQdylFW/PBOuuy5cxQbJrT7U+ni/HLh1yK2nCbw6htnpiWHBLUyfctmqzPhNcXHYyk0k5tbtLPDFtW4OTxE+jE23I/H8d4UdhUkaBR+T6pquDXh72umnB/xvTWeYUrYcesQwfaRQH2wHgJ+YY2v+nvKbwkOIg5urUFv7LQ3jpzwSwM4DoGE056CblQdzYL7wD/BvLe/mHgehHQLmhdZOax78h0Lxy1/9Mv72978XAVXLW1VyqNfNGs58mC+HOx2Khxv4QM3bU574l68Cu93HIVw8EP+t/Qdb6ZRHOM5A+seN/yi3GzlcO2jxQeF7CNtuu21QKF3z+5dLLqnFw609bvNxwcCIrUYE48Mc1gyME1dmOxD5kY9+NMwHXl/TwZmywJhAP2htueWWKx55dFPz9YSna08pJ+Dk0LLDny++9Mo5HFfv4gdgCbddZFDHBS8dcqbs2yJGnsnDkWC+8Ch55Gc8+M24cECU8QvO0gRySnCrDAX1nHPPKVezSsPvLr/88iCbDho1KtZ57zrlykrycqmllirzA2fk7QlBX11Y4lIHDhs6wjm/P6eTrsEbP6G0f2KbT5QPDdIn8FxlyWpXxjrczemDr1NYwdf4zectt9xSrn+nlHIE3vzPf0oqAY8wNw75m/ffn3NO+WZJSWz+WWmllYKiin+bN7wJftsGjdbw/yZbj/v/1ttuDReGGPuTTz0Vt91+e3G2gcHq71w9/vinPwbYGxicc1UteUmZh+P0I/FkHucb2qB/gSfDwLzQzdAE/uAyALKYAadOAfzMLePXfOFt+NGNN90UDkPjJS6B0JZ+cnY4H8GRnJmx5tA1C76387e3ZnuDAYGYPNdxYWY8KQiXcKcM9e3TN+67976glLmdARO47m9/K4QOmQg4DPLWf90ao0YdFMojcMwRYhx/wglx8iknB8In4F1FB6EIOh5K1/i1KhAYs31siNhNFU7WT2gMGYh/8bhxwUAh4BC4W0d4666dcG1MmvRAuVO+9LlvX/jbGSCq6+kgfmdk74+2hADPyJlnnRXvXWedmGfAgKluc6m46upMzMkeb7c7wA/44rpESj0D07mHae1dt9rEy+G6vmkBAH7ykL3nPe9+1a0bmCxjFL0wENYaula5xcutS5OaFThp06qzneMIdPCab/754p3velenYK99RrNo24oehYtRxCOHDh3M9eR9cl7ARQXmqJb1ZFzxOpkbigHatiohTSCsxpwxJsCQ4dXKC+QTh3Y5NCjBhJzrIzkfzIE6elJwMNWNLqusvHJxwOi7j1F5CnCacHUwviidGTH5pckB5whXiqSVNbeVTJkypXyszDWtygp4sosn8DznftADJUCaMP8CC8SujTedMYZPgyNDRJpAOaY4U4qVZ1igI7/lhy/y9YSAximdcAiewvHMBqBN58GOUsSYcrsUHK4KVZMc8BzOM5ThG3k2fPjw8sE3+cyjfAJYU6IYzuQantS6FW7QoEFFSYXb6px/vvnDDTLKohfeXfjvFkLXwVLCBPNN+e5JfMW4rbJQ2NE8RyL8yuyAu9+8/3CU00EecDBOt0E5V7LzzjsHYxeOMhAqrOSTn6HNIDFH4gbMM49HCcozJKwcgffkyS+Vq9tLYvMP/sPpYK4YC26N0xc3k5k7KztNth71vz5z2Lj2G65T/FdaccWwwoD+XVe60IILFdw1MHz1A5tuGowmTiKrOvjKiy+9FHg8Q5U8nWvOOcu2OHPgkgA8AX8Ae2caOGc5H9QpWLWQRg7QJ31TicHguuChQ4eGFeh/NsYeXq5+Roh60BP5+dGPfLQYzv+69VbVtWWY7Q0GQsk2BIyLYIZAFKo6WxgrCxVDtOxK6fZ1TYIeYiJKvxkZnvvvv3+5E5sXkEeGcIS0iFtbzz73bKy4worBe8ZAofy1CqHxl10W7qju2yj9lEKMB1ETWE8/+2zwCujTc88/H+7KHjVqVCMAd43ll1s+pkyeXLs91ZMXFBH0tOXdqQYxm7wwEl984YXY/IMfDMRpruvQMzPgEgHiakhL+4Q+hrnkEksUhvijH/84CIKNNtqoFGstf9/994ctHp/YZptykFcaReKcc88tXr1rG8NUOm/keuu971XlX2hwDh6rn6dKXgYO4xXDve3220qZnvQP5n3hn/8crrPzYZ+uNDRkyJDY48t7BGWdAGfsEzAEtxuUCFnefkqCdDBtHT+6Y8Qz+HmsLFf/9eqr47eNI8HHfVy3RyHaZptPFIMfT2kt77crXQkVypt3Sol+UbS896RAWBO6YJKZ5Rsi99x9d9Q/iuiQwYODAsUw+OKuXyzKJf7KKFPOtdMUHlu10AHFuJanDIGnq3133233IOwZDKefcUac8rvfxcMPPRT4PL5N0ZIXTtfynlYWyAHbNtCaOPxcH9TlvScEcoRBhE9wAuy1514xR985OrsObuBk6wtHgStRayJHGKWdMVDmpKEDsGJAuW6WQpTZoQSjAzwATOdolKwHGxijK4YIZxoHF5iTc+QafkUWagu9oAvzmpnBOMvMkJdChaZ4duXtCcH4GFjGtHOj+MN3W4/E678n/Pcb3PBfOoAnQwscPMHMVjGGFLrP7IB1pX3bbxhxaATMrH75eBsPN96gToYJJZRjQ3s1UE45Gm3JMS/italvPY2HwzmOkwcnPVgMAGPBwxlmnA/wiP5Db/JbemaW7x7Ba+XBHLx5+jkmbBMyN3369g28XpmBAweWFQrwByd10hnxZenw2Lty3uWjD6IheeGBtOefey6eevrpmKtfv8L71IXnwxe0Ki95oo52DHSSduxXt/WJ0DVBLEGGA8QgyCFA5itECrkwL4hggjM70lilTzz5ROlv3znmKFuPIAdmrQwEQNAlw8v/9J+7f7H61QeJXo4uD0qZH9rwlA6ptDtg7rnDqgWB2a9hzBBdW/Jg1PJH43XTd8gLCRGEeHWI87s3tCcECNK//OXiuOnGG8OeUoqib4FgdObOXFKaeN6EtdZeq3wU0Hz7qCDl/Ybrrw8G79FHHx3O4fAcKiv87brrgsdrzJlnhnjbi2xbuKhRmG1tO/+888rytS0CvzvllLJtzoqEdpWHr4Qhhmp/OG8WBQpuCS88/0J7AvZ1enXJpZc0XqS7wh5rq4iWnCmjxguu88wzTzg7QOi6XtUcEQRoLzPDnlOK1A9/9MMCO99pIZxqecLZ3lTleMHA7Oqr/xqnn3pq4DMEvfaOOuqnYX54uAgZtKt9ioQ2eK6UrUPRvjz1vac84TKhTGlifFHw8V3xYCbYrmn1lCeV0gT/jA+vwxfBQ5rtWs5A4LHyCBRXW7jWfvfaAUcZbOji3HPOiTNOPz2sGGnfCpztShRX865d5cGcPPD9Das52hXgfmaHIuu9JwS442NqVsbBiZFvfHWsZJTbqMCCAUDZrOMCC7/Rtd9Wvu3Dhoe2JfFKi1eXVQoGgtWBHx55ZHCo2fKIp5wxZkxZHbIKykA55NBDy6opuQt/9ccKEcVLfejFHBeZ1shT7cunLz0hGA/HHEMMjI479rgYuMDAsnIJVuYELOC93QOMUPgHt9G08vj+ft/4RpgTfIn+ADbKe+LrzjGMOvjgguP4jy1NjDOrn2PHjSvedfTBoUh3qGXBUP/A1Xx4F7Qt7vnnnvfaYwL4XTvh2uKZP+jAA8uWRLQOxnQlOOmcAgMKD4ZLgtUAq5HFqfvJT8YFF14Qf77wwnjqyafCvJCLxx53bOD15gRA8BZltMkRMU+jjw0cuEC5IEceRgpDG/5yQiy+2GKx2OKLl3OG2oTbePggcU8+WXACrwd7uJKZjfo2pcRrrx3DbG8w8KpYFiKoKWmYoVUEXiYTDxEIEJ5AW4gGNZ5cng+CBpGecPzx8e97/h1Tmv9YjwwI5RCoCUfgfnsK6iMc5fEOkeSrwdIXZES8mDOr17alS8ePL9uReN7eMXhwLL30UsU4ObpRDPXttnuXzB4AABAASURBVJeXsdQL2e3DMx4eUO2woCmbtZ3eZ/tBANM48MCD4pv77x+W/zEbWzOsKjgYZW7FwzurT/DOnmFMyPwSsvbK777H7gF3eAIpuoSI5W/nYuyh3P7T2wdlSN3KKwOP7Kv92c9/Vg7pWkIl1CzxYq5owlYNit7o0aOD15L31WoD5ghn/W4/qL5+jz78oQ8H4Wt5mgJlK9hcc/ULMObZZDD5uifF/vgTTihwpYQaL7p2yI7i+7GtPhboizfQPBHqtiCBlfMgSy61ZKiDEPv8Dp8v8PMhNwL9Wwd8Kzb7wGbhy7iME+Xsf9UGRWriHXcEryGl1Wi0S7nTnveeFIwHrjk8aOsdPgtPKfEXX3xxY7zdHeBNiBLWDDjwxA8ff+LxIJBts6EkWdU69thjy3ZPfI4hAWZw3VkHeAu/7dHXnnYHN7zTfOOpeD+aMZ8UXIoa2E6cODHw+f79+3eCFg3i3fJ2Rrb5D4YXQ4GnlaHEEws+Fbftf4eDVl8orc7k1CFxnIE5Y8AcgTmFh8OAAXJng5NgbpuW1YlDDjkkGAiUVqtvlFUw/vWvflW+xK08eKMLbeiT7UlWSF1DzuCQZj7B2NzCcQoVulRmhoSZXAmDgNxlYDHQyGZ4xYkD7hTOI35wRNnSbKxoGv6DNbp3hooha/sLWMvj99XNqiQHA4/3N775zeKdfuzRRwsfgasOPx//29/GSiuvHP/zve8VOiEXlAdHRjndAS3deded5eNgDJEKDvOs71YaalxPeM4111wx8nMj48CDDgy7MRZZdNFYc621ykq8FRg4OXbs2OC9R+v4KlwjT+H+H//4x7KaaQ44Gg7/zuFhOxc+MWzYsFIO3YON+WQswOsTTjyhfMxwwYELBt5hyzkDzByRzeBtlX+Nd70rGCvi6I/v32CDIFfxGPSJJ+kbXg43nnv+uUa3W7ptQd+nbXvWTR1bbrnlwgE3DJKAcJjFbSUUd8Lf/kvMD7PkBWDFUsKUgQjK2FpEWeJ5pUQhdMgCmRkXlDf72uwTRJCUA2mQ1L5FwrEOd733rVesZV5K+3SVZxnP3QgvRoq6hq65ZqOcLBUHNx4GcRS2j33847FoY9Fq1zImZYdQ5V3Td+8UxNpO77P9IMBT6tAlRmXuHU6jpDP4nnrqyeKZ4y2Ba5geBZ8XCo7w2FF2Cp4NWy94w22pwPjEP/XUU8FD4lDh+u9bvzBXqxSEu3bhI6/qek1Z7cNv3l1L1gxcglt5+0IpfU82/XFoSxm41a/fnA1OLtl+QH2DHqHHYesOK4YAeG6x+eYxzzwDyt54wsF99WiKwH/ve94TDuMyosDknrvvKYo8RYshZ2sHGgdPdPlss/zsfu1ttt46+s/VvyjDjz72WNl6hG/Ix3AD800/8IEwt7aD6TJ4E+7ybLLxxoGmM1NS5zYbbZWIHvQPLxxPNeF9TaMEMdQ2bsYH1nAULySw4TEeSFGnPDKYKKiGyqizFYmRTBl6+plnijMFzOQFF0osPmwr2TzzzBPwG8zNN68ixRnewmfzqW19wOPRXNfvbjA+CHr8XR96QjDukSNHFgUEnMgRyo+x6j/Y4B3X//3vAc/JO/ECvsDY+stf/lI8nmDqVh2KJbnigg1KFDzHs7ZucJxjjSxCI/hOhTnctRWPsntHY4zZKqNd/QBzPMzXuZU3Z/gW/DDfjAdx+tRTArmOt8JHxpZx4hdgBa677LxLOZBLf6jbjcHjssvGlyHiCTzj5su82cKC56rvpcmTy3ZVc2MeBPy9wprhQYfxXZA6V2CsvKABW6LRmDLeBfhtzgYNGuS1xwTjtW2u8vAv7rprrNco+sZvSxgHjTxwDm8wB+Tpp7f/dFnBYdittuqq8clPfirQPTzHj+Dr0DWHBv0QzTiUDw/xC6v0iy+2eDmXA1DmheMXDdEB4fHw4cPDPOAttqsqj7d/YaedAj3YDoZHmQM0yri79JJLY8455izfdVFvO4Z2Mxi6HUb2ZFqSrQ1TkAg0DAzRD2oIyD5BypHVB8TME+wAi3dWqaXvIYOHhLoGLrBALLvssoG5YnqQ0AqGMwgUj+WWXS7UTXgRiowTXoba/qqrrlYUfx43+wx5h7UHaZWnyOkTItDvA5tlOH3ba889Y7HGusZoLOfzegreLc8RHvpS2+l9tjcEMKqdvvCFci4BPm299TYBDyg8FEvzDgcxHAKbd8JScx0VPIVbmRkYlMO38FE6pQhOvhY+ZGZRoOGwvAxkv7VFuDuU+s1vfLPkIYwuu+yyWGONNcu+UPX3xJCZge4Je4Jl60YBMgf4AWGD1h1e5hkdMmRIcCicdvppRZkyXnND0aFQUgp4tZ0r+dxnPxtu4uA1HzVqVDBI0K4yrUHeXXbeuWxVpCTxljHG1MshQSjKjw8Q7pkZhJu4nhTgE77nDBeYGhuYcWYQuMbOKw5WcBzvJagZCG6bYVDsu88+xVkinZdw9dVWC/iMP+KreCSeiDczrlvhozxhTlFTXhkwRiv4qbmhbIiXV1mGBX5sTjM7jDbx7R7wfrLAOAVwGThwYHGQ4SMURFtnKEHwDd7XMYHDyJEjy5Y7yhBYmhN4bO7gP5jjK+YPLzIX4I5HKF/rwjc4xmo6hUycuQdnsolTTjojBn1Rdl1GQNliZNa62v1pLPiAFRewAlsOGLhFT4BT8AvcyWd4DWcp8OPHXxaPPvJI4DOHNM5A5W29W3uttaLSx/KNg9OcmgvlzcVSS77iqFm8cRqqmzPRnOPVyzb6CGNweKPEoj994ZDijABPhvf48eMDfpsXcT01cPrAHzRtPGAIRlbM6VnwaY011ohBSwwqcIavyiyz9NLFIWfceLyy6IGTjKJvdYZhBoYHHnBgOYOKJ/dvHLmcc2SsNtGMeSFL0Bp44i14ncPoVhOUQZvaNj9kDkPGqoV2F15kYd1oyzDbGwwYW+bUQkCcgLgys3gEIRtij5f/pNU4vzOz5IvmLzPLkmE0f5lZfssjZHa8R/OXmSUtWv7mn2+++PT22wdlgbCk1PEifHXvvYvlqV+ZHf3NzNAHocZrQz/FCRQMiMzyZcW2NNX7s40hkJlT4ZP5jZf/6vyaa1GULB4LTMe7kJmduJWZnXXFy3/KZnbg0ctRUz2kCyI9a/uZWYwYuJXZseeSQKoGhfyvhJ71yxgzO2DS9bfxijMi8N96m22C94iXVZxQ0zOzwDuz4ym/8kLNE13+MrOUieYvM8vvzFf3BT1TStAzHhE98C/zFRyCW4bgCTaZr6SBF9hlZjBaPzdyZFmlESfUdGVrqHXVNO9dQ2Z28s3MV2CsDnk9Bb8FigKFi+LgvacEY6hwAo8K3/o0jpour/fWQCH60m67hRWcmk89fmdm4S/qiuZP+da0Jmqq/zPfGOa1vILoCk+hWHnvSQFMwKiOB2wE8caR+WpYUDitKJP1ygrTKp+Znfy3pmd24HCtu5ZtTde+II+n4Ldg9YM3fHhjUHjvyQGMMzvgYYytMDAu6eLrb+nivNeQmYX/RvNH4WcQWAGy4puZhXeAcZNc/lc+c+o2xZXE5h/tdW2nxqknM8s5B0YcR1VGNqXa8//Z3mBot2nJzLLHjReCd5O3wP5P14BBurfaX2UwAxY2JH2r5Xvz9wwI2Ko2Kxi+VQsMlbeyZ0BqxvTyHcssE7xV3e39RMM8hFYs/Z4xo2n/WghWt3tZOevu3sJtOA7Xu7vtWd3eRz784Vhr6NCObnTjv0OaVTy3YHVjk7O8KTsarEZ0d0fsn7dSxLHY3W33hPasUjJeZyb9mwOrfFYf2hkmvQZDy+zY29by+h/3k4XMQ/kfN7DZfEDmtV1BAN/auX9vFm7tPoZ279+bhfO08sEhYVpp7RAH9u3cv7cKo3Yfj/691TG1c364I7RrH8G7nfvXHXADg5nZjvq7G8bTM55eg6GBmsNFxxxzTNnD/L3vfS8sCzbR0/W/g0UO6tkeMmbMmHDouGtF9n07ue98Qte0mfWuH07kQ8zahuszHZ51MMvhH3tVa1rvc+ZAAFNwQNlXKd2ABRdaW7L9wW0xPhA4bty4cs1aTbdM72aRRx5+uEQ5TOe7DQ61O0Dn9he3F8G9kqH5x3w7hOW2GUF5+7G169CVKz/dl+4QaJN9qv/hhWtCTzrpxHLQtjVRvW6COPjgg8OtNOqT7rzMEUccUeLgk5s/3FTR2if5ZlUw5iOPPLJ8NMxSfNd+oAmwd35I/6VPnDgx3KaBtl2/7BYTN87UdHkEMHD7hnl1IxKak0dZMHETjXytARwdqPZNi/P/eH5rUjkfARfcsKFOt8jcdPNN5T5w7bjdyi0zCtljq09+z+pgzHBD//A5ON3aJ4cE3RDibIfzL1NiSjm07Kpf+AhO4KKMa3uNWxlz43yDbwp0nTttugFFOljUNt3iA7atdaq3BrRgbtBaLVPT1KlP8MFNN/rEqeQWOv0cd3EHfapbm9Jq2VnxhCtwtWvb5JHrVd3SAielk3HijA1O40vi7WUX8Bq3IRkn/iGtBjTtxh94CT7m2O1V6nZVs3od1q35W59gjEfgLa3xfuuT235Gjx4d9tWLE/AOeOJp3t1KQ27VPsvTnQEeoLvDv314uboa3df24Qz44bX4Kj7izJH+exfgPpoHC+P07rC4ODSDtsG/1umpTbiMZuAqOIjXFvx+PfwDa/g7LfzEm5SHw9rQf3zEOQl8XRtu2IJb0ry3a4DneEPrOMEYbOp8wFuwEG8czv6BJ/h7dxsVeIBBHa8Dy+bInMBr166qjzxQpjXAydtuvz2uv+GGwr/1xfyjJXMPb2r+F158ocgheO+cFP2sFZdqvnZ6zvYGA2PBgRQI4SAX5uhwihsdCCmIJCAmShXG2Dqp0sRR3iALwkJsjzz6SLkTGJJBLPkwB78hIqVR28+/8EK56xcTVkdFDm3L3xonTRvah+ja9RsjxawhpzzaqPVpXxzBiLnYxiC/timbY8eOLff2u++/5pW/N8wcCGAODsQR0gQrJb8yLy0SLPDnvvvuC9fCYejizemoUaNi5112idvvuKMYEq4ppESZS4o7fHGtISVffuXgC4GhXorOjl/YMY777W/LnLvVB95QRtUFL5URlHF4D56eddbZ0ZWZYbzO2MA5DJQQx5g/97nPlY/dGBul2VYS7WpfX9Q9qwLl80u7fancxe+aTcZVa5+MwRZABhiDDm2Ao3GIA4vdvvSlcosZRarOTR0PAevAoo8vggV64jSQlzBzKQJY1PyenAYORt5x551hfk86+STRJYAtYa2us846K5xbGH/p+GKMuTZZ38zBJZf8pRyWZggRbqXwLPoHn2QsUETxKIcOHV4Vr0twjLDFe/Auh/7cxENRFPAm8CJYjd8VlYQ0GHx9331DGQo+WNc6KU+uxYZzYGILJwUILTiAaN7BmLGoDzW4QcWNSXi9/upHTfNkGHIgSUdf9z9wf5i/ww8/PNDc3l/du1ypqJ+uKHWrk3LdHcgIVz2FqeIlAAAQAElEQVS6cYrjoLV9csfYwO/cc84NB4spJ3CNcoRn7L//N4us0n94jyZcx6lO/MHBW0pWrdcckSfmyPyYQ1d/7vWVrwRFi/Np1MGjXuVk0E+0tMceexQarPV5oi+3K1Ga0Z3rn8lAcsy8OiAK5uQXucdYgV/KdmcAG3BjmPr+ElzUFzigH3g5YwZfxiNdu4xP4B14IB5j/PgCWmAcuaxCGbQMtkcddVRIr3V6agNdwHVtgjHlGL8yn/DcnOhDDS9Nfilu+McN5WY3PF57Nc04yHxz69pm+H37xNsLb4Hf5srFAEePPrpT1minlm+nJ5ijd/jPYDW22j+wA3vzgWfYRsqBJR6vwJ8Echk/gMN4Nbo3V/gN/mXs8JFuaP7RB35beZD2wNcc79rI6PP+cG5jMLxYrrcFW/MpTV/k1efjjz8hXKjByB84cGC53pXjurVOedspzPYGA6ZHyFLiEA8hYT84hZ+ShDEgGoICE4OQBB7mxVOCGWNoGCekwxzUeeu/bg37mx1+YVlS4hA6ZgBRHVy0X+2y8eMD4mHUlEfMEHJi1vJSbCBURRoMg3GjLyxh5eQjJDERhA6ZCV99owgiIIaQcxHuC5bmgzAsX/3QR2cdahu9z5kHAYLBfLjB4pDGO0/AYlC1RTjkWwcYm32NN//zn+Wrp+acUJaWTWb5ePco6PDX/lNCFR5rg5LUZCuHt9xQAv823mTjcEPEF3bcsSg+9gnbm+32Djc1ZKYiJVCe4C/82mnnnYLCALdKYvMPHHXjA4HocKR3CpobUtCQA1yUA/2y3159reWbKrr9fwIDzaEbcOO5ptTrCCZN6dNXe4nBxG1HDCe04xpDCsCyyy0XxmfPr/ERPMoLBIm7ut0CYz+q2zZ4BX0cS5sbN/CnIBAs8gvSwe973/1uuE/8tFNPC32R5hYTN3gQ4Pbuu23DDWvONnFyEDZu8bjzzrvKdzXUg/aVnVXB2PA/d5JTYsCZE6XOPYVofMPzpLshhxHUJ/uUr9YzkI1rtdVXCwIevqvLbTyMkE032yzUCQYUYHzUOCmb3t0w4ryW24DM3amnnVauD8YbOYPQmvwCGFOY9MN8+v4Fz660Gihy5t1BRDxy0gOTygcP3fJkT7OLBhw8Vzc8p2DUsq96zsQIhpBvUAwaNOhVrbhtCH8B25/8308CTPF9dAoulMK5554nGGXw2cUYbgcDd2XMh/FRRiuuu2GJ4YGHwUW8apVVVglX0VJqHRB/5OFHCt9q7RAnCWPA7TMU/9Y0cg1NkZHwQr/FUeIovXhRZpYDvw7Ao0uyrLWO7vhN0dMnV+xSNIuDoMFn+oD27XPnaCF78VR4td122wVcwYPxAucU8Bd4i/7BizKJN9M30IT5rDTD6MM/0T8ZDs/xXl5rtKEtdeJn+lADWsOTveuXZw2MLboB4+Xwb387XJxhzs2xG7H0Y91h64Z+OfArnaJdy7fTkyMXb8bb4Rb5Wvvn0DJ4wis47wps+Ar/jJ+sXKBR1uWf0vzjRiUGsIs8yFAG6z9uvDGU47yBl99peDXaIE8efuSRplTH/wxu8MZb5pyzXxOZYY7JGPODZ5h//cMDyXQXZ3h30xhZet755021utZU0lb/z/YGw4QJEwJhQxAzQ9C4v3fZIcsGqx5hvWOZd4TlXIfXMUbePgIM8yMoxEEejBgjQcwECQEFmaVBIooEImdlUi7uve++IighogOrBOuFf/5zEUrSCSsIrW3Wrf5hotrFuCgRv/r1r4LST+FHAJdfdln5giwEpcRZEn300Ufjnnv+Xa5mMyZI7+AkRoRw1NsbugcC5qJfv37litRl3vGO8hRXW6dwEt5WGSgsFFhC/i+NF3n//fePRRdZJMwZnFHGYXaChXIKBwjwaASruZUuZGZRCP7vJ/8Xn/rkp4IAgJfwFdMiCBggcEs5OE8gw2MrBAsvtHAR1ISJ+gRKBIZKQZjQ0BDGR2FRjpfwxptuLMwSM3RoVHzFYeVnRaA4DVxgYBAsDrKhoap06o8+EtS8QQTQHHPOEWiVsCUwwQifoDwy5tQHZsoK3gmHiy66qCi2FDnzYa6uvebauOWft5QtigQ5OIMHZwClHw27EU1/xKuvBnhAId5rr71iYCPcCD78haILN4xFnygTV151ZdmyVMt29xOOGJt+wh3KJxwAF32RfmezmmIbAAUHf5LP+P/2t78Xhfbmm24uuIPHwikf7oLjK66wQsFDeElQM07UCWYEM2eNAP5o6qknnyy4rm70wbDWDx/HevyJJ8pKEQMQ7CjByqivBjwUr+XQEUc23H3PPUFhRDPaeu65Z4tjCP5TroxV3u4MDEWKP/yB061t+16Cdwo3PANL7xRY75wO4AiHKDEUo+eee654leE8XqXMgw891HhMX1K0BDyI44yDi4EGHxnJeAJHm/lXFq7jNerEdyha8Jc8bIWVOaVYm3NGL8NFeTJwj933CDyk5pdXuu15pTPd+I8+wO8F5l+gOGPgDfxppdnMbPD4pvIhO8o3XqGL+OqvG3ntClWwQNP0BzwfnOAQuHIKaaPOJfwms+kTdAl4B+6MFPXg++jkzrvuCvMNv/XHt192/PyOwfMuj77rh6AvaEbbcMP833/f/cF4ETgf8fVNNt6kfMOEjsOIN2/Kt1OgbHNMVEOgdZy1n1ZyOQgYSHAJ7BlrjF5X0TIWOAI23WST4Di68qqryvX4eMbkl14q3xiiT+EjCw4cGODl9jAGRW0Df3DlOcNAnH6YR9/esfLHIWw1Xl/okJxBq622WqE1+dHe8889H+Sy93YMs73BMM+AeQLDJMhMkEl+8KEHy5Iza5U3C1He3RCjQKmf3Cz1URR4syARzwyEUA+FAsELlbggEoOAN6Ag2tNPFySZMnlyYIoEvXTMh9Lxz1tuKds6tEXAaQvD1T8Bo+e54AGAwO4v53VR9oILLwxKJK+yLSfq18c55uhbCJ9ChGFJVwdmFM1f5ive5ea19/+ZBIHMjD59O8gOrmU2702Il/8YlBQAzAVe2Lphtem+e+8rOGEueerMNRwjCAgs4eUqwkyqu7578h4RIvBZGlxlKB9w4IHhDnXe1V//5jexxZZblg+I8d7VOuXPVKuaouw3P+/888t3AHjO11tvvbKcimkTjpbJr7n6moJvmRmEuzq031HDrPu3jkkPss8rY9I/tIYuGGuMcVs4CFUCCR0pK5SyzbiU8bsGXjnzd+ghh5QP/vjN20gZ8CVSBokyVvc+8tGPBmGF/ijM6pCWmZGZXkvAl3h3rQbBC5Hy4xW8v7yxlG48Qp6nn3p6lnuoMrNzDMakz5npUfgeGFJYwZmiQznBqy6+eFwxtAhpSgx4wac+ffoU5Uy5Ukn5h4gvP8qKTGaWLVuMavyWMlDnTC5lKWBH/OAHwctnRQdPVbd0IbOjj36b95NPOSVsWbLCk5mhny+9+GL5xo6+U/BOO+30MlbjoNRVnq+O7gpgZcyv1V5mlj7q25SYUmDZp4nj8bZSTckhRyj204I3GE2ZMnmq6uEtbypYGntmFmOOkQUvwYKCa5vRiK22CsYF5Vg7mR3XMbdWqA14vUmjsDGMGdk8tsbFGGnNy4BniN8x8Y7W6G75DesyG3j2aULznDJlSoFtZk7V/p8uuCCWX2H54qSrCeBxX6OUk9fwkXEFHni48YuTN7OjrilemoAHZGZYgdn/W98KSj6jQX4wa7KUOY1mbu10oLCaA/hdjT55WkNmln5r1xjgRmYWfQSeW0H62FYfK7JBOUYj/GgHHq4/rQGdMyLBwlha0+pvq3/0JrqPbXh2boA7OccpdPNNNzXgm1KMf99QsJpjG9fEiRMLf+FkUj+YZ2ZUuE1poQuOCd+MkW9KgxfR/DF4zzj99MBD7ABQpx0htoH55gZnEOcwwwJeq59sb4q25f992rJX3dgpX73lpWNxmjTbDwhyWzAyOxibSZx7wIDYqLG2eVE233yLogTx6kizlLTiSivG5AZJIApmilgRoaGIEzIzusaJlycziwfHu686W560bIm5MAAgrHw1QNhSV8NV+vTtWwSxNAYJpVKAiPIQvPMvsEDpM+UNkfCmyaMebVKWEBImLQ2TUl/PDO3b64UWWbgo3OBs9ejJp56K+eafP3gqKPHi3zF4cDAG4MAdDcNa5h3LxJJLLRk8p/JhYpZan3/h+TJQCgOvLa8TwxUDVZ7SAxcF+O1Oc/OPoRHEpY7GmwhH4PHaa68VX95jj4DPDFB4U9q7446Ct8rBEXEP3H9/vG/99cveeQKMMCEACStb3igSlFpljAuedcXh0vlu/GfIskOK55oyA/b95uxXVhseeeThsn2Csd+3b5+yT163MrMIEIomeqBM4QvgjNEzuAgd8OCxI4QYZsaLpswLuOAZVgMID2U+sNkHwlkIW594mAgI826OlAEzbWiXgObpMx8EEjp1fuH8P/6x9J1XWZy8DBP9UYf+z4rQt+FFcOu+ZvXU2Bm3xtOnUfrhoyc4wjlGjvxgC2b7feMbQRHnyKBIGQfchafwlmf/kUceCfxrmaWXKUqSuZSuTeMF9woDhp750Be4iY9+YNNNYo/ddy9Gg9Xgm268sdAeGaBNfQF7fX3k4YeD0S6+KkwUMLDWL/hsPNo1TxTi+i6uuwOYGr924QI+Pm8jtzIzKgw4HjjCjvjf/w2efLQKDsqBI1wCd3Dg6QQLvIUxar68q9+ecW18fOutvTYr2PeUj1mVuVlmmeCBlx8v2X233cKqgrmWWVuegvbMKUcWRwM6onSBJRkqj/zG5regb+A/cOBAr90a+vbpUz5QCT/gN7zRNzgnDm6Au/gtt9iyKJY6KA+llZMRbxYHP43D+MwJmIIFg5kR1m/OOQu/UjdlNzOjOBkbvgU+jCb4jSfzWq/xrnc1+Pr+gt8UXvipHfVr329PcyiNroCm8B9yg+cdf6PYcpxst912RVYpZ57gh3Le2zEYp6Bv+In5gINWJxmg5B/6hD94MUPUyj09CP89/oTjw4q58kMaGWx+4aygDLwkE8lfcPKh3KWWXCrMt3lUTqh98BtPP/nkkwKtwOd+/foFObT88svF+MvGF7qxEo1/mBtlwVnZdgx92rFT3dknyo6tQs4m2K99mP18DRIQLggasSKkTTbeOP7ceO8t2xLghLeVBxOMOfDsWbpC2AgYIUNIwhIDVo9xEXx+i4M8rEpBmvbmmXvu2LjxsjBexl92WTmEpA5Bnsws21jUIQ7T7NPEeVfeciLEtK/R9iP9I1Qt5+szJmAMvEuUHv3RD7/taWUsWZJDLNrrDTMWAqutsmpgMlYNfvbzn4W75c2d5VKMi7efEsPzx0AYOXJkfOmLX4rDDj2seF8xOl4SuPfgpAcDo7M9CD7BYcqkbUzwgiebAYyZYUYMEKPBNAkEcwwP/nDeHwINrPPedcrXPjfffPOgzMJfOHHuOeeU1QRCShuEC4Fk647zO7aXWGWAXyeccEI4hONalgAAEABJREFUs4NBwzX4R1khaGY1I9ykMfh5oqyK8PZR5Al4fSZwLRFPmHBd2O+KHsAI7RPiYMUYIjh4iwh3qzUEAXohdNEj7xGYKuN8CF4ATpQzvy2bgzNnAMXYXBLGRx55ZNinLB0ejB49uiiy+ufwIoMxM8tHg9Ds8b/9bZhfsOeVxUOuuebqMD7p5nlWBLzEuQAKOty48M8XBkFtm53+Er7gykNqzPDXKgn4H3fsseXWGQYYT7VtEBTQpxqjGn7isxRcjhBtgD2eDcekoyH4id9tsMEG5fyCs2fmg9JAWVt33WEB9spb5YCblAReRs4Zwh/s0eQntv1EwBX9xo+VhzMTJkwo8foDBygn+r/88ssXr+2sgHtmBv6PxtD6xc1qDW8mY8dWi5NPPjmsgDGAzBFZxgiyJQl8wAyuU4TgjzmxxRU88Y+haw4NMs3hcvXDb+MdtPjiZbj4D6UH7Zj3gQsOLDwFL8HTGMbmPjPLFlp9yMwAS/RHYYYjbgFCT7ayMSxVrpyx4VvetW3e6oqbuO4K+mLrCH6A15562qmBhuGi7SZoHA699OJLxUiq/YJ/tiA7H1nHwdg35ocefijAW7kf/O8Pws4C+Auv4bt4bTh8awXBdk/4u+222wY+RdbjGR/4wGax9lprh3i8BYy1Dyfw5swsHwhzsJYybUUYHWpDn4YOHRpjzjyz8B304DycW/X0A89nYOBx6mzHYJzwRN/wlZ/85MdFITdXzzzzbDmHIA3eO3uCHr6+79dj+PDhgbbhE9hz7jDunF3CgxgdeBJnD1pCL3g6GQhuVpLJWXULYI0fZ3bQ5LhxFwcYox0wt03swAMOjEMOPqS0jYeg0zvvuLMYaNpRTzuG2d5gMLnOLHzta18rk7fXnnuGJVHMyrIeIpKH4rbjjjuWL47aB8djIh1xQjaCBSOBdJiedIeoCXCHE21xgADa8duyF+SjhFDypWmXZ3b4hhuGvY9rr7VWaAvTJcDkgYjaxGyWGLREWeriaaCw8dBg5gibAKVUInAKhT5idrZFyUc4EgYYiy+YYg6QmRBVlnKovd4wYyHAE4pZjRgxIvb7+n7lMBzFnBLF2CQ49ttvvyJA4Belk7JtPnim3N6AiTESVlpppbJPltfT3mCKmZt4KOoEuDYGDxlSDEw4TgjV0fAqYpjwwRdGtVNxTB5M1e0OmKKyhD4BJJ/24eyBBxxQmLDxqAe+wX2/HR4j1DBb3ny4bgzqnlWB145BbCxowBjQ0yabbBpgqL9ujyGcHXzT5yEN/AghXiC0zYACV6uLDDO8wdyhc7SqnHdbY6ywgLktH+oEb/PWOn7tKoPuta1P6NlcUtzM4+677R5rDV2rKKPomTGn/2jeIWD0TaEdP/6ysm2BEGttozt/Z2aAG3wkiPEVvAdPAjc4YKyMM/2GL/ghvBJnDvBIuA12cM4WCSss4Ic3wS38lZJJqIOXffR4JoXY3BC68mofvNAUD2ErLOQxn9qWrk7wBnvz+cVdv1hkwcabbBx4OVww5+rHkxmO3iknFDZz11p/d/4GV/hHXmWag6EB/vCT3CIz0DEYLbvsskVuwB3xtrrAQ7TOEKZMioNjaNl8GDt4kVeZWZRh/KmO0VyA9ciRIwM8wQg/q+n1iZfhT/opDk1pg4FA8TWPghuD0J08eBHcwP8or4xIvEp/pHdnyMxAw2AC1/b/5v4BF/AWMAMH/YWjcL72DZ854FvfCvK2xnH+wDM3nxmL1bXNGqXf2OVThjIpD3nN848mwBaNOYdY8Vca/lvrrs/MDPn0DS3Bh4rfeBIcQB94EPrgwOL0gDPmEn5TlhkQ6LbW+3aeM6ssfmhrIx5Jzm611ccCb/B7r732LOeZtJ2ZZbssmjFmeM5Yft967ysXWoDLV7761eI0M4fkMwcY3gDnOXXwdLQDpvBAeXXDSzQCpvqBt+FxZAIYO0+CBrQNv8XBA07fMWeOKX1kiKurHUOfduxUd/cJkRMWBNuwYcMCoyN0eUUgi/7w2DIIECziZs1CNgIOQRJoGAUiVxcGqDzk8Ft59WA2fmPanpiBctIISYaKMhS6WjfEki5Q+ikilAn5eI09MVOKHCS9+uq/xo9+/KNyYJNhQhggmswshILZGKfxIChj9NvYBP02Pu31hhkLAXhlPniawBzjMH/mzjxjOJiMuWfIYUi1B5lZbjmqZcztJZdeGrzbGJsyGDy8ggfmeeGFFipeaTgIB1rrIqzNN68UZljT6lOd0uE2fBMPL3lD9JnQRzPa0SdjY8jqh6c+8AbyvhKArWNR16wIaMeYwBaOgzfY4wGZGfot3VP/xRMIV19zTfH+gJkxmyNljQk/MHdgBP7Ky4dWCWhtiZuWIJBHPJjJp011oUEw1gaeoR8VXuoE89oP4xg7dmyYF8pLzTernmACpsa05hprln3RcFKfjQeuGKt0Y4M3xgd26AKuggt83XqbbeLS8eOD9xpMwBEOgg1eqx7wUCe+q06KEzgKcFSZOh+tMMnsUP6k1/kGS+2gB/OJT26w/gZFkOuTOuWtZfTd1h00rV+t9Xfnb/0ybrw8M4sB7D0zy/ZGvAZswNS4wAqsjcNv8Pe+0sorFw83+IpXps4HOWWMmR11kletY4R/6qC4kY1g05ruNxiiQfjgnfyBA/ACDPUHzLWVmbKUrXdoxNxYPbeNRjvaKxm6+R+whk/6StkDK/gC1+CkgCfob+2aMmQ1+Nc45SifeItVBPOFptEJnAYTdZoveeG6+UBbaCzzFX4lThu17tanNsHWfKhT39Tpt/qNwxxLV4937XiK5z03PjjUWm+7/aYDwRPjAD9j02+wMy5xXfsMjvDYnGVmuQDH2NcaOrToSuBE2UfjeBDDUDraUDeYmzc6o7ozs6zy0uP0Q7q2wVKZrn3QtjZcq+2smjM/+quudgx92rFTvX2afggwRCyVHvm/R4Yl5eHNcttbq603d0+BAAZkxaEK33bsN2HFe4uptmP/3qhPFBweJytvrQrAG5Xr7nSKBg8vAdjdbc/M9j621Vax0xe+UJTGmdnO26mbgkzQUyDeTj2zuiwFhxecguT3rO7PtNqH37aUWa2ijE0rT0+Ks6LsjEdXRbKdxkDxtmJCsW2nfnVHX9CBObJLhFExs9pkOJPlnBEzq40ZUW+vwTAjoNhGdWRmLLTQwmVbAC9NG3WttyszAQJLLrFE2RM8E6qeIVUS8PAQ450hFc6CSnh8XL3HeJgFzb+pJhdqVpKmaTi+qdLtm4lSCH94Q9uxl5kZvPP/KcoUo4enNrPDu99uMMdHKFftrGC/FZjhKfC7nZ0RVjzxlsz2xIm3Au/pyUuGWc0yV9NT/s2Ugc9WL95M3lmZp9dgaKBvn7XDQw58OdTYRL3h/w66OejkzICnw4lvWOgNMjic4xDU62Wzh9NNEvbNCg5/ufXg9dq3v1lez675bBcx/tdrszdt+iDgoBs8aS0NXxxyNY/ipZsbT+9dA5ywh7Tm9xRnzv2e0hR49rnnyi0/zc/yv6VThxi1VSKaf7Rpn7Uyzeur/rck/ka4pw4HIFsLq097rW0Zi3zSWvP6La11vPZLG4u0txvgNlqs9aBlt1rYxtAaBzbGUuO6PpUTaryxoLMa98KLL4Y7uOv46pgqHYnXF/HKeK911ac4aUIr7Gq6pzxo3dO74LfxqL++wwfzJ01ca1A3GJsj8fponsV7786gbTRR2/QOJ8FJnD75Lfhdx+Pdtjv55QMz46np8hpj69zLJx6c5K95xbcGeACeNU4brfgpXrr21eUdvOHsa9Upz8wIxgMfat3aBz9jqHHywG99lF7j6xMsjM+YapzfreMzzlb4KqPO1naUBXO8ye+uQR0Ovnedk675jEefazy4wuX67glntN+aT3wN4vXRE66AifZrek96mjOwh4e1337jQdKME/2CEfjjS+ba2Gv+2e0JLubb3IOPd6HCQZw0ecQL0rzDUfjlvQbx5qDmQx9gLh6c4WjXMrWstrrSl3LwVx9qPk80V+kDHbgdS3w7h9neYDBhDg75GqADKbYeOFT1RpPmdgcH4SCSu/Lf7mRDTreGjB8//nWbhqgO/zkY5so6wSGo1+ozJP3jn/4UZ//+9/HVvfd+1UdB3N7ipoTXbbQ38S1DwL5Ph9cwhdbCbnVxYwKGJM2tK+bSAUpz25rXtxEcnpLHjSfmktB2ywX8gzOPP/ZY+GaDfb3eHTDe4fM7lJtgDhp1ULmq1w0XDmnBFffKw9naDgbozvrPfe5z5XYNh1WdO6jp9YmhwXe38tQ4T7dKOABoLN710f3stsMRdOJqIMj1wXgtv4KBw2S20DFma77peWrLIW3fRFFeW8YKduaBYYyZO+TnoKzDcbf+61ZZOwNB4HAhmDsY7aN2U6ZMCTftuBVDG4JboNxA5je4HHrYoWFM23ziE2E89rs6YOrAooOkDg+Krw3dd++9Ac7StANW2qnp9WnO4QWY1jhzo6yPKIlz25M6BB+bE9caXMagH5bU8Sj8zmUHHCSt+Wb2b3ByMBOuacshSjhnfhw6ZNidcOKJYauJ/jqYCWeN3dWsbi6CL/DVbVI/+b//C/RCmP/6178OB2kdtvUxOLA0d+px2NNB34kTJ2p2qoCW4HSF5T9vvrnUY8uLA6jqp4w5wO6A4w477FDOCzkA77YaY5qqwpn4Ykxub/FRNM3AVXiNnlxagO7BBl3Bb/jgVh3l5BfACkylkxnGJt7eafgsnXLjZhy3uFFSwcjNR/D7v0eMiMuvuLxcsYzGyUxwR3Ot7eAF6je3yjlfo52uwUfIwNa8ok14ab7IYbxP3N/+9rfy4TF9Nifiaj3G66A0moU32lQXGHH+1Xw96WkOXM9sHo0FXH3Mzk08aMG8u7VLHjgJxmDm8Ozb5aE9CU61r3AArsAP9O5gtsP/+L888JfMBSPpcIX8dcPZyJEjy01qDtTDM/nBGG7T6cwF+Psgo1vGvItXD7xHN8rUgF7IQjiPR6Mvc4gHi8NX8CF9Mn/oxxySL/LCb3pDra8dn7O9wUBwUoIo677eCWEwTE+WImQhsEyyCRRHOYNgmFLfOfrGqqutWg7I3HLLLeUjcBAL0/RkwWLmV199dbnii7Dxm4cAMqrTE1NQr73Ijz3+eFBw3E0tv99uCuFN0C9Mg0JyzDHHhMCAGDJkSDmU6ZYL9VMSKQeQ2EdJLCteN2FCQExt1jB8+PCgaBhXjet9Tj8EzKV5xDAocwSw2jC2P/3xT2Gf+a233VYUedezOaxJ4adkVsVFfgyPoCY8KXsEBo8SfICPzqpMvP328pG1E084odzzrByFaeWVVg6C9PTTTo+/XHJJYKiWVSldc/SdIzwpu/JTetTtZgfXvsEddRiHdEFfKOOMS/nFCQ5qEdLwG57Bd4oGpZwB21oHOBiPLQ+usbz6mqsDfjsQRpGtBpB632oAF21S4lxrqF1KpWV+Y7WUrK1TTzstKJLad2jx+z/4fnZbbF0AABAASURBVOhXbc8cUMgpsG5TcvjSO3iAtzkkrN0OBfba0XfKLmVukYUXLsYbWiS00KVDqL6XseBCC9Zm4rZm3vAF+4IpTBtttFG5AalmoKgee9yxQQmgWNd48P2f//f/wlWY+Af6plgQRPAEHrV6fDkfGDeMDodQCU74pk+u7K04UOufWU8GqnGaC0oNpU/7+gTnxJmfjRs4mMddd901CFowx+/gb92G4gup4IaXqQcMXPcJDwlyMAeDcePGxRprrhkHH3xw4JW2fbSO71+3/qvcQMcoA29ze+rpp5cP7oHp9TfcUIw//BSvR6vy4bf6hRe30mtr3TP6t7nm1EI/5Ir6tS2ecmy7xLixY8uH5X5/zjnlWxYUFH2Gv/IL8sLXGk8xAnuGhYPI6ASNwzsKFZigLfQNrm7t+87h3ymXaYAbmDNAXGeL3rWBJq648opyNSdDDl8x7zys0gW8Ag67XY0M1Y4PWZFD5kvfGejGh1YdhqdMmec777xLFSWQyZQtbcAbDgJbO5ZYYolgmGqnZOxB/8Bp/MS12uQHeJL39/773mKoUVIzO76r4bIVV9CCGZlAh5G/Bw33bXc1Mztv7MJjyCc4YJugysk9xuSoUaPK94XgNfw46+yzy+2BcNcNR/AZPuFHBxxwQMBnsEQfHKoOU8NhN0jBe4fu8dtWHmouzAP6Ug4O39Q4Ia76618DHqNTcpl+MHbs2HIjE8cIOiGrHID++S9+MdVuAWNopzDbGwyQC6O8+OKLA2OkLLjmDSPzm4KBeDE4gs+1WqxM8XP26xfPPfd8/O26v5X7kHnQCCsKFuRx7/L/HnlkHHLoIQEpCC4IycIlyCuyeUIgSOi0/Z/++MfYb7/9gucGQ8YseWEpMc+/8EK59YaCD/l9FdpvdWD23/nud4OnzvWaxkOgPv7E47HSiiuW20qMtRUB3fZCaVJXa3zv7+mDACZDAPJkVNiqiTJ6woknxOdGfq587IxgwDh4RR1edgMGnJNXINgxMOkUV3tIKQsEIYWFgL//gQcCzhAc2lWOp4XngiEMtxmKjER9ceuRKyLhhTj5HeTiYeGRpMwrk5mSSlAv5c0NGW46gmcSKOY/+tEP453veme5kUU+Atp+f+133dONLhgjn21WMox39dVWD8YPxo5RSqt1q/+tBHBy8wdY2eOs7H9tuGGgVYxf2wQHmIIdeLntBfwxdvkFSiul/M8X/Tko21Oa1QXlwcrNOcYHXlYGwEkZwuYb+32jMHkCxW0kYG4+1UX47/3VvWPQ4oNkD3CSD/ys/FGS0GhJfPkf5QYuMDDQsL37yqBR/OC2W2+N9TfYIPrNNVfhVwSkFRFXemZm4FEvVxPuEnfjCicEo4QTQX1udqF4KFvzzswnuA0dOjQ233zzMv7MLN9m4PmHp/phfghyfTNf4G0FgrIET5Q3t3DRePFJfYZnFFzCWL6lll46tIdW7rzzzqAIwHc0KX8Njz/2eLk/3+0ljBLx22y9dezzta8VXv5iw2fNNfyE0/ATHrj9RNvml8Kt3MwO8Bu980aCk/bQELlgnPBpzn79wtiP+P73g4Ktz/3m6tf54TBl4LQbv5Q1bjwfvqgDPcAxuEbBMm5lGGpWYSg0jFw8RHuMTnPlxpiBAwcGWCurzLvXfncos/zyy5cPH3aVOejcOBgM5k85xjZDjRGpX9rXDpyVX9/N+6KLLqKJEsyHvPjmmWedFY8+9liRjXDeil4rbZcCPeQfuAyuDET8B+znmHOO0nsG0urvfGfMPc88sehiiwV8RN+MJSs2cCVmo7/MLFenuslv4sSJRbZaccODgQHuuemJfKDjjRgxIhiYH9pyy2BgLLroosXZC8aZWT4GyQHjTBi8hPMPPvRQuT2JMSD/ho2T1UqGtPvuvz/qH3mCz+oLOvPRtr9dd13RvfCLkSNHxj9uvLEEl4CgDysf+D0HBBmMH3Io1Trb7TnbGwwUiK/ts09Z3mY98qRABMQHiSjsbklBqIQ7BiaOQpiZQbDcf9998fgTTwSExXQxOMzuheefL4x02LBhZamb8gApCHerBlVQ8Vzx5KyyyipFoBKYkJwiR8BDLsbG3/7+9/LlRwKRgUGB4B2m6KjbB3Bc0/bZz3ymEIF+6NO8A+YtRIUAuiKgMWJQ991/X/FgdE3vfX9rEKDUDG2UIwyFUklRMbe//s2vg5AevuHwsgpl7s0PpUQLAwYMKIqO3wLD0BPDc/BTXQQgpYiSKg5jsjRKeGtHfooFxZ/R+uJLL8WzzzwTGBN8ZvhaAdBuzU9w6y+llecELjAOLv7LX4JHnud/SLN6BW95aeE3/INrLzz/Qlj96NO3b/HUa9cWCf3KzILL+iRoUznj0HcKAbyH3+qvRq+8bzVQ0hkp4GJcmRkOgzu8CQ4UUorn+u97X/nQHY97WWJ+9rmpcJ7hwku91tC14tLxlwZvNiODQlTDZz772XKhAFoSCCaKLob/6KOPlpUj4yQEePTdoAO+rWMCYzfR/Nf73x/4hA8+ES6nn3FG+VAjHCLUKH51PLyrxxxzTBCGg9/xjnj+uecKz1Jvv8Z4gD/gD0fECeYUffsN3vrLUCX04F9rXnlmVjAvtk6Ak/EYH8VQfyma+qkv+kYJtPqAR1LMwUe/zCVagIcMV7/Fwx/1w6UHJk0KX8L1Gw5vsvHG5ZpcuHr++ecX2OKZlEm3kTCuKQba1Sd8dsC88wZeWvtEATOf+L4+ohft4s/yMWC8z8yA7tCV/plDbYmD9xR+eGclYdFFFil37pNVHFKuXaaQyy8YC0PCb3jrCf54EDigTXREXknTljRGApmEhsSZI/FgVkJD/2CkTGaG/HgOY42jC03pI9j/4bzzGifbc8F4HN4oXuoT4Cf6wyvJX3MooF1zAb+PO+7YkKYdQduMdw4+ePWdww8vK63wW/qkByd5dIae8gNOoxfXzVo9AG9x4ID/r77aatG3T5+peBd8wHPw2Z4yzhnZT3jDKUspJ0+61m2HhpVC2/jgOYcEPD3uuOPir1f/NeAQXmlLOoMabqmD/pTND/QB/njWnHPMUS4aeeHFF8pKaJNc/sdT4bEX9IFf0Au1h1+hxeeefTbEw2dxZOHkxjFl7shudd/4j3+ooi3DbG8wEE4myTLUscceG5tusmkQMAQVBkbIEQ6ECuZMiJlYzLsiVTbEm5kBAQgUzAvhZjZxTdqQwUOKwq4cQYXRQyKMMpo/SpgylZl7MmS0jbFr3+85XmbMFETX+FkS41HiiVMXhH7n6qsHAbrscsuFOJ5Ep+/V2TRVPDCeNRiDvjz7zLMlf43vfU4/BDABpcHfb9tKCHGrA1aXbJfhMes/99xF0c7Msp0M7ignwMnM9DNemvxSPPvcs2Xu4BVmJEH+zJxKcFBwzedee+0Vm33gA2FfsA9Y8U7CYR4QOEUAqUOgNPAIUooZzeo98cQT4n9/8IOiZBkHPIGj8vNIMp5t6/j+//t+2A7Bm61+9cqnjLw1qBNDZmDLV5mmejFPzFa5mv+tPNGdemp5bTMUKDEEr48QXXHlleWDSxwCxm/FZemllio0qy1lVlt9tfKhLl6o/3r/fwWPkjr0W/3a6TfnnFPBmzCn1Fjd8IVb25colzyDngw6OKANQTuUKdtuKE0MgNsn3h5n//7s+PGPflRWIq0+aAuclBHA+7bbbwtL6LZOchRQANX90osvhn6if0JJfgEe1Dr0MTMLDhlP3z59y6qIfDM79G34VmZ2ws08UfzAlFJLSWUwGQ9chBu8xNKNyxiFzCyOEDAU9JugxZetGv36V78Kq254njmE8xRK8GZw/eKXvwhGM1pUNvOVPsE/3mr4a8sT495WqJNOPrl8RJHiZq5OPPHEQqtw1ji0r66ZGcABDLVX22GgUuJ5KDmWrp0woSjL45qVcgYxx9FWI7aaaoVhrv5zFYNWHZRxY9V/tKl+7cCN1nbgFHzcZJNNYnRjsFK8KFHyCGUeGoUHT8rs4FdgSZbafoHeGMfgj/f97KijyjkQ81lxU3+MRb0MPSv76AovQ6vkmzEuuuhiwYEhfw3mhOH3ucaQ109y2xiM7aknn6rZetQTXNDxAQceWFa76CPghR+R/RRdSqYx1oGhG3NY5XyNn12eVgDxD46WrmOGo+MbBxAHDN1IOjnqg2qjR4+Ob37jm2VVLjMDLcBreQSXW7z40otFTpgT/Ei8p7zzzjvAawnwrjoQ0BXjYaEFFyx8Vh+koRPfRtK+dsTT65Q1f5nZ6QgqlbbZP33apz+zpicmHoO1xYj1fsddd8TigwYVpZtgIfSdLxjQIMbQtYYWD4f9o5Q+ir5eT248ufM2HmKTLp7wu+3W2wqzhhQCxPCUv/W3d0SuLKbpvTVdmcmTpxRlfvLkyYEl67NlWP0QMGN1WJ7kWcJU7b21lEYIWo5T7zONdWtMlLuxY8eWfabGwHPEgiYw5OsNMwYCdR6tHNnXuOMXdiyrDMstu2ysvMrKYU8wLzYhTMkZutZaxQOO+TEQCUvpl112eTz6yKPFc0dRqXhSewkvtOXdMrb9zhRWWzG0zTjhwadciLOVwLxf3CgXlDOHsqx4bbHlFgGfMK6fHfWzctjXqgPGqO7aDm8WBYpiZfVtueWXL0u2hJp8+iL4DVedA/JOqSP8rIhZml1hxRWLAqNvxtoqAJV9q6H2T1sEgS09BKmDZEs0NI2+zxgzJjZtDKknn3oqVmuW9tEd+qFsHHboYUFZkd8coBuebUoTJaj2R/2Cd/NG+TemcePGxcKNl5dTgTdLWR9rkk95tEdRNqcMNMvPtrUMfsfg+NreX4uLLrooHD51vkIZwZg8KYA//b+fxoc+/KHgHbNqYZmbUMK7GCr6xBlBsTCfvGbGgn/ZD738Ciuoqni4eMcYiCWim/4xFn0EC6sqcKvMT7NMzysMf+DfkIY+jEO3jE9+wta7oI5aFwXRiq99xvguvO7beAAZzOLgO1gwmk85+ZQCY6ti5l1dtR7lRo0aFfp08z//Wc6QcfAMblZzKLLqAFdzqp/33/9AY7z0j+6Eob4K0fwxGCnS4Ke/Vq3uuvvu2HmnnWLZBn5wkBwANziKxhjBaN77pePHFzwyHnkoOE21Rc6Ar+DduOE3ucYxQM5wejFYHIDGWyhqvLr4GOcI2WJr7IitRkRmBhy0MgQHGbuVJtRvPJmv5DH/ZK7+wHMKHkcLHOao4MRDx+QaGnXeQbtWkMwF5xiepk/4lDZ6WgB7CuWgxRcP25CNjwEFBubWHBiTba5gbSUHX+WcqGnSZ5fAwAILBgEcMG44gB9beaPf3H77xLBqKU1+jjQHj60owDV4K146+At+U/id+5OHk/jf//53OfOJ5664woqx+GKLFyMWPcBreHjlVVeWLa22iqEVfSMDrRAPHTo0yGRx+IlVN7LPiqs28CG0rO12DLO9wcD7wRtlop0vmPzS5Nhh5Mj45Hbbha0VPK48HdtsvU1ssvEm8dnXYKJfAAAQAElEQVTPfDZOPuXkuOvuu4ryZ4mKYoGQHTzkCaTMD1tvWDlUs846741BSywRkGLYsGFB2GDSkMZvSEEJtPyIMUBagkp9FHjll1pqybI3z744ij2FQhu8XRgFBYRQJfAIN+cteBSfeebpGDJkSBEM/fv3j2HrrluQm1ICUTHgJ554PCwXL9V4WzOZI3rUG94uBHh3KcievELv3+D9ZfXKPlzblZYdsmzZo04h4jW2dcX8EOzwAONz48IVl18R4y+9tGxpYxDCScyNEquPlGze2CocedPFOwCMgdnbitGpVxy8GjFiRGCiGOoTTzzRKD5zBfw7+6yzy55vArsyTHXVgNnBTWPCnK3GGYuPaxHu8FVexs6KjTHA8MAEKXIYuFUxeGg70PANN4x3r7128YwzbuBpNUzUMT0BTaEN/bCygAkb8xNPPlluMUKntm386pe/jD4Nru/2pS8VgwW8wcNeePDEB8CJdxrsKFQEhT5lZnEmUFyMD0zQJQWOEBh10EExqDFOKMC2LSojEASULisfvLWLLrZoHD366CDQKGTmW77WoI66PK4fyn1wsw8Gw0+b5tw5AMYJo0f/zY1+UKqU5WXHJ9T7xV13DfNqK426ebvEd0cwJ1Z1KIDm2Y1DlHawNhe8xP0bHoUXrvPe9xZ+p19gKY6hpe/iCFS4ba6MgzIKlzlL9th999hi883LLWG24eF1DhbivZmv5m/mD12BhTMv5mn00UcHeKNVSthijeL2iwZn8Oa9mpU7Y7npphtjrbWGFoVYn7ojWClBZ9qyzYfhTz7d0xgKn/rkJ+OxRx9t+rRWNJ0qdGz8+ATDgUIDF/APWzeWbeQCuJiPaP7gRPNoimbZF49WyCer2/IxSBm0ztY5NwUu5/3hvGCU2fMNhujcIU88Zc011ggHdfE2c2NFQ/2tgUy0oqAduMrAP7ZZ5UcnDAHj5ZQgfxnWjGbjZyzYVoYGtt1u21AGD4H/5hGt8gYLre31hN94Ct4C7zMzhg8fHmAOvsbD8IV/4GtbItrmAOS4GTlyZE8Y4gzvI7pkIFPQa+VwcOzYi4JuwygFU8q7dDTOILPaXvUoNKKezA78R//mAv7Lj/+QCeifrnj/A/cHvk3vYoDTpdCBPhwz+pji3DNXq6yyStAxyQf8ykoZPmglhByEx1ZY6QHoR/+ke7ZjmO0NBsKIUmV5yiGYgw8+OEyyA0WYFYH89f2+XpasCGNeYktY3z7s2/GVRngQWB/beuugSGFobsFx+NleOWm77vrF4klG8OIIS8oZYURAQgqISRngzeGNwZDt08VId955l7IvldKpXu3or+1I+mzJl2I5ZMiQIAzEWaYlTBZacKGgQCprnFZSajljpVz96U8XFOT2W196w4yBAKMQc6A8t9ZI0flkI9wpS4Q1JYVA2Hnnncu+SLgnHQMZ3giLgw85uNyWQ/nEcDA5t2jdeNNNRfmDk5RjhxYzM9QPT3jK1asf6vQOl+G0PhHGFHhKJ2+3A4dwn9FJeGe+Wrni0YSbreOhTBFUcF18ZgYlzHYb/aUUSIefmC+PmX7BSwKQgWv/KeMKvqtjekJmBgUfc1YecwdbByu/vu++ZS/7wIEDy3WmFAvwQEvoAvz0jTICBtKUM6ZBjfIPVtdce23ZPoZWbVfB8I1PnRQdt2KhfQJD++AEXn4LaB0+rLXWWsUDbEVhj933KB5EcydP10BpU3crXNRDmapl4IP5s6WSBw1/0Td9hGN4BVoHczROcWNcrL/++sWh0bXNmfVuDJRM7WZmwEk327hNCrzxxMwMyj8jtPYDHcBHRh3DTTy4oBG4Dx7qxQPVRyk2pxRqdGBe8GV4qGzXwMmDb4qnUFR+SjGo8+8g9N57f7XMFWEOZwWGm3LdFciIESNGlObQMDzWT094RflmQBx26KFhHLs2BiJFCkzBGyzRP7jgBeQCBxRc4q2nRGVmkSPgB3/AknGnHPxG13DMHKkH7tU43tqNGp71wcZg0w+8hDwCY22Xjrf8w6AnE+s8ohdzCB+MUzscE9qAw7avmW84j84563b70m7l8Kp0uPXMM8+U26KUk97SXI/4Cebod+jQoWWHAtjg03ANfPB3fAd83MyGX5lrdD4tGPeIQb/NToIHuoeHtSpybY89vhxwDA2gBU5R6fAKvGyRI4/AkFGsHsYYfqAu+dAZuYBnMig4NpShA8rHQEVf8gx8Wb7AV/SFf0hHP/ivcvgcmiJz8Cx8m7MQbzvld78rB7I5RPSzHcNsbzCYFEQKwSAUJUacYGLFLbLwImUPmzh5Kf+QQV4KxIB55ikrB5gZBJOGWUE+ggriySd/Zsc+Yowg8xWljMJiqZx3RBvqysyyMuFdXRiCetSpv4MaZUbQnjb0D3FQRCH2SiuvHLXNzAwCopaDlOrlAWYZq1P53jBjIFDnybO1RvMErzI75h6TgU/wQT7pdZ7NufkSMDPp8m41YkS88PzzZU94ZhbFr6ZndswzvNWOMuox9+LgpTjtUBYoctLgA1zyxOTk6RqUhTOt8fZfim8dp7rVkZlF6Blj7Z/fxlDHyxOEWVMC423+qVO7tRq4T2AYHxiIBxNw0I/MLP0Db32O5k9e6eghM4sRR1irmzepyVJWZLST2TGH0oyJcSZdQL/a8lvI7JiXWk6btW/SpxXATD9a0zJzqvk2LnMGR/zOzHIzjT4pZ770zbgys+AMA4hh0zpn8s7MkNnRb/2p7ZgDMACLzA5Yglntu3xgYGvV4CFDyl7gGidfZkcZcwd3hTom5bwbe2ubyrcGuKt8jQMn8y8+M4vHveDRUksX/ikfnqlPhL/37gpwpxU2+gh+eL5xwzk4CBeEGq//FQbKGB+8ysxQhoKKF1T8Bg/tZGYZmnbBEZ7BMZHgS9aBsd/izKN5IQ9rP6SDqf7J0xrE6VtmRzvq0Y6++y2v9oxDvDFkduCRdjI7+i9Ne/JS6vSLcVXrUE9PCZlZVtfMgT5ndrwbL1gZU2YWvkTug6+x1/zKzG4hMwtPhKd17OQanAYveAbfPaVnZtGrKvzgm/TMDjyEZ+rK7IA94wyM4Zb64Jd3+JaZRcdSRt3mCX2Zq8yO+tQFR9GBPAK6E6cP6nn0kUfCqhGjsPZTvpkUprvaXoNhukE3YwtmZrEueW7ebs0QdPMPfjCGDB78hlXxbM8IZe0NG+rNMEMggGFRVniw25mxvNnB2ipCYcE032yZ7s5HMbTtCl11d9szuj2CjMedwJvRdc+s+ghgW0RbBe7MauvN1MubaDWL0H8z+ds9D2cVpxFlp937+kb9o/jBbzjzRnl703sh8GYgwMHCAcuIfjP5pyfP0sssE1Y92p0Gew2G6Znd3jK9EJiZEHgLddufKbyFIt2a1b5znplubXQmNtbu42n3/k3P1MAf45qest1RRv/amQanBwbGND3luquM/rUzTrwVOMCddh6L/glvZUz/aXlnNr6BrzbaHW6zvcHgUJgbThw+dHjIIRSTZgLdNOQAqFtpnIp3QM+90g6rOHjVEybYWHpD+0HAIUQ3gnTtmQNWDj/5XoJ929LtLb7i8svDvmC3jDjIJd5+dHjp3aE/hxnHjBkTbtSQXoObityO4tpPdcNbQf3ixo4bW66KrPlbn9rwQRp1tMajD/1X3u0/zz33fNnjby+0L8fqJ/px2NlhSfW0lu/O3+CjP6NHjw4HKFvbJqjRuBsswA4/kO6Qmzi07sC4OMGtMGjfuFwcYJ6Ul1aDOh06xi/k0X5Ns+3DV67v+fc9NWqqp7l2AM+tTVMlNC8O1umTSw3wqyYqxLn4QLyDq8qbD7fnSJ+VwQ1FcKBrH/TdfDiQbm8weIFRvUXHAVvzJN4WTbfDVPwT71A3Oular3c47bYgv8Ea7rkUAk462C6+NWgDrFwkAKdb0/wW5zYrhyPRDPiSE76a7JYT5c21OZOuTNcws9/RO7qzVaprW/gCvIeH9veDAdjDdRd0OJAM9q3lwAOfMFbj8+4mpq7jQ9OunlWfutCOeVEW7sPDrmVqO2gIXOt7fRqDQ6V42U033lSjyxOuOOfnBV4Zs9/dHcDl/7N3FYBxW0n705LtNTMzxGFmZmZsoA00DTTMzExNQw0zMzOzKcY4sR0zMzP9M3Kcprm0l95d4f7z2trVSu/Nmzc88yQtz/FTe1yOB9OFbzjnWKFcRpg2TGuWRbbZ5fLG/ODjfJ77s1/w8vYGyy5/L9/4PMswP92H5b+crmyDmVZMi/Jj5X34k20343Ht2rV/sPHMK5ZlPs837nJ/PsY6xDD5k/nPMsT7fI5h/t02phXPn30R31zMNGUcWcZ4biybbK/52Mcbz5lt0I2bN8CXxrK9Yr0ol2e29az/bIP4RnyWTX5oBd9kz3zk+w4+hsf7TG/2CSwfTC/uz/el8jGWCaYx05R9BtOYx2Lc+D4+3mcdZTh/1+1/PmFgBeXHa7Eh4pu4+BF97NCYsUeOHhGfQ8+Cx4/F5GSCHRY/mYBv1uK+f1fGVuD196UAyw3fkMs3rX2KJTsDvvGPgyS+SZYdIz+SjZ/JzUZmx44dYMPIhoUdCBsuTmj5hkQOavg8G0E2ogybDRY7YL4Bkfuz3PJjCtlJ8Q387LjWr1uP6zeui08M4j7lGxtEfswk3xDNBrX8OH8yfnxzfdC7d1i5ahVcXF6Kz4HnG7k4mOJAgnHn8dlZcUDF/f7sjZ17eUDN8+YbCNk4l+PBATfPsdxx8mNp2SnwjWts4PkpMPygAKYx843tANOeHQAHReyouC0nGOUwmc5MB54z/zBQeR8+z+f4XiVXF1f++g8bBxN8gykHoR+fZKfC9GZachLDQSA7MB6H7RE7RZYXDqzZXrHz4fMfw/gz91mO+XpcduAfj8v4caDF+HPAyPxg+ebAh2+A5vkx3Tn5YcfKssRyzZfi8bz4BkJ+Yg4744/h8j7rA5/39vLir+AAk5f5L1+5Aob7uSSM7T7TlenONl/s+NEb851vWDx69Kh4DwXTlW8y5WCCfUVEZAQ44Ob5cOD+Udc/ZZfpyTrP+v2pjnKiyzfvs65zG7YLTAOmBSdlLLc89/IAixFmeMwzDhL5MkG2D8yXS1SI+JTmrONMA/5kG8OBMgeWjAvTnuWcx2a4H28cmDFe3Ofj47zPT7rix0JzsjFh4gRwsMbHOWDjm6cZPn/nsfghHhxI8/c/a2OZZNvHN6uyLjNdeWNbyTiwDDFtf9zyIzh45Et+WW45aGT95ICUbQrTl20jPxKVZZ/vQWCZ5zaHqLDBfGB4vDHdOVFYs2YNAgIDMG/+PPE3Yrgf3/Tu4uICllGmK7cv33j84cOHi09GZLu2a/eu8lPiJ9sRvjmX2zHPeHy2OwyLdfL7Cd+LfZnGrIesC2LHv9Eb84NljWWZcWc95JuZ2f4w7dkGs7/kp6WV+0RGn4vELNfcZ9vWbeAiDPsytiGs42yD+XdE2H/cuH4dbIN4nx8wwPrDP8rJ9p9hlW/cGL5mOgAAEABJREFUhmEy7TiWZBxY3/imaj42ffp0sHyzr+Bj3J5jT9ZLtm/sy1n3yuH9HT//nyYMv4/U5deC8014bAQ4g2Rl5ufvstFkaPxYLnbObCj4yQ/8rG9uy+cqtgoKfCkF2LFwZYGrG5+7JpKNFT/hg40I37jHhpqNDj8FYuXKleIPi/n6+YKDV35kIT9tgZ0PyzA/hYF/U4Fhs1FinDhoZIPKN+6yg+UAgcdgZ92pYydwMMyG9cH9B7/4wRgOPthx8yM7P712n50ZO0W+7nk1JQvt2rYVgzMOvtmAcxA4b/588JNs+Jp5fpoEV3p57ozTn7nxPDjI4MCGg3d26B8HMeww+BgHgVt+3CI+Y/ve/XvgOXJCxzTgBIKLBRw08g1yfPMn05SNPvfjmz3ZMfHceeMAga+35ySOnRc7cj7GuDC84qJi8QeCPqUD05QDAz5ebnd4nzcOoDggZZ4zfXm88IgI8I//backkh0+y0FCYoL4lBvmGweM3PfP3jgIZ7liGpbfDFiOAztdCALYwbOs8vXBHLAwH/hGbH5CDgcsfG8LP4mI5Yaf/sS2lu0u/+4CB1fl8PiTbTXTjmktkQgfHlDBelC9Rg3MmjkTzCt+VCI+erG8Llu+TPztE75J8qNT4i4HGIePHAHDYYfOBzl44yfyMN+lMim8vbzB94Cx/j18+JCb/KkbB30cZDCdBaHsJstyBDg4ZTlifDkA4hss2Y+xjLGtYBnlZJnvYSjvwzLDgQ4/dYn3lyxZIv4mRfn8y9vxJ9OFn1jEfpELIKwXjA/bL/7OAdKn93kw/zjAZvvFuDGcjzeGyU97Yj/Ltot1hwMrtpmsp+V9+MkyfL8CB4If9/+j9xkH1kO2fWyPp06ZKgaTfIzHZhvHyeSQwUPAwSA/eYtt7Zu3b1Crdi0xsOdgkunGRQBe+eF70pguLKOhoSHiQxUYVvnG9p91hHnBT2ds2KCh+Hs5XCjgR8vyOEwzDjjL+/An85GvveffPOndpzceP3rMhz9snGjw05iYTzo6OmD7wTBYD1lGGjdqLD6y1tnZGXzPE5/70PlvssP2lmnPP5zJOsl2hWWGE81BgwaBEyV+ihEnvixPjDbbIA76+alanHBxkM83MvN9n5wEsH3lOXNywLD5CXlsj9iGB4eEYNMPP4i/18P04GIBw+SNZZGfOMa046d4sZ/lgpKmlha46MZ6wsUrlnEVVVVwYZCTEuYtj8P4Xrx0UXzUNsP7O24VCcN7rrDTYcfPSslOijNQdgJ8WhAE8MoCJxL8S6EczBkZGoqPUuXzFVsFBb6UAhzscPDPxuNzCQNXefipIBzA8O8rsFNhh8LVWjZOZ8+dFX8zgY07Gz42elxt45v8OGjggJblllfJGCdBEMBOm51/aGgoOPhlOBwAsCPiQIxlmx0Ww2HDxRUlhsEBP1dSOOhn/WB4vHE7hlelalXxl4M54GBcOAjgjR0ZByhcrWE4fJ7H5n7c/3dv/0YHDvB4RYCDC0EQxMercuBeDpL5UVxSAr7sIjgkGFxFy87KhiCRgGnDjoZpyQ6IAwFO4pgnTGt2MvzJT7tg+nEwwXAZJo/Jc2bnxTTlVQ2urPOTO5j/TBemaUZmJhge04+DC16N4ASLg1WGVb5xAmhiairSmwM/HpefRrN1yxbo6+nh7r27oj3iJ7rxk3MEQRADvfL+f+Ynyy87bk5meY4fj818mDZ1KjhQ4aoxz4udM9OYecDznztvrhik86oPyzMH+gZkbzmI5Edrfkobhs+0Y0fNNyQzLflYRGQkYqKjwYkfJyIcQDFfmB8c2PENhvx4W37kIusbBx/cjzfGmyvnr/38MGLkCPGpNHycAzDGl4O0xIREcADO+sE4/hUJA+s/B642NjaM3i82tiWcFLHc8aoMJwjcgOnDOsp9mEeC8HOiwYkwP0nJ0tJSfJIM2yleteF+H29MH4bPMs7BECcIYWFhYJvCdOZAjauqPObHNGfYvLrA45bry8dwOVFh38t+mPnBtGZcOPnmILvchjC/OFjmVcPPwfkY5n9yn8flhzR8ao9ZBngclk3WZ563IAhgG844s6zwxsE7B6K8OsArFazH/Khe7s/V/mnTpv/DSi+PyTaFac00ZtvLusK05r5sy1nn+Twn6SzfPCbLKiffzCcvTy+xkMA4lm8cBHNhgYNWXmViH8JBMds1Tsz40ewMi3FkvWL5Zp6U9/87fDKebJO56MVyxkE7y3WDhg3AqzV3790TfwyTEx6mE+PM8sL2muWU/RsH/lwUY5vM9ONkguWQbRTbf/YhbOOZvpYWFjDQ1wcXOtiGJCYlMUhxY5icMAiCID7Olduzn+Y+LPcMMyU1FWHh4eBjzFOmNfsatn/8IJPs7Bzxhw5FgH/DN8nfEKe/BCVWBFb2Vi1bgRWJKxqsLCyQjJAgCGLmzwERK3qvXr3AhozPVWwVFPhSCrDx5+fh61BF53N9BEHgAqx4ShAE8bcW2LCwo2BHwz8sWO6sODDjcyyjbOzETp+8sbHnhIMD3s2bN4uVKcaBnzPNhpOXuTlw4wCAA7QpFMyxA+EAl50E48m68QlYwpHxFMTDgiCIl2vwvDho42CxZYsW4Io+6xQn4gyfDbrY4U9+Y4MsCD/j+vHw/AQk/gE5vsSInQ0HkRz88Y+HcSWUAyueAwdZ7ExEA0+wmOaCIHygQ0lpiQhWEASw02Ba8GUJvNTNlS1ONnifnQbzgp0VX9+8ZMlisFNnm8JOvxy+COyjN0EoG4sPCUKZXDDPGQ++f+He3XvgyiXzi4NyDlg4qOD2f/bGwQ/TtdxBfzy+IAjio2zZKXOFjS8z4aCXkygOfLnaaWFuAb6fgenENBEEQUyKGCbLLssSPnoxDfhR0hwolJSUfjjDT1biAg9X0VkGmb9Hjx0TV+mYZowfrw5wsFBa+nM/BsCXS/GKBsPMy8sHB1IcqHEfpi8HKfxISy4uCYIA3ufzJZR8cv8/a2M542Dmc+MVFBaKPouTLH5+/+Ejh8GyyAEkJwbDhw8XE9CP+3JBgWWI7QrzkWVZlaqhH7fhfUEQMG78eLCtYJ4xXL7URhAEMM04gGOacnGN7cC0adPA15Mz/RhnhsnnGVb5lpeXB15J4xUKDnaZL1yhZXz4N1NY3svb8icHbeyjOUDn73/WxrThIgvbYw4mOaFiu1E+vkCrXOX7/FmKUvDTD5lWTAemKcs3J8ssNwyP5ZPtLdPlUxliXeancvGleizPfHkT06J84zFYB0pIhtnGcOLBdGf6skyuXbdWfFQr/04Gt+WNg93Hjx+Dg1SuzvMYbI8YjiAI3ES0bQyDv7Bd4kLTX2XDGYdf21imODHmlTSeL//Gj462Dngujg4O4B9QY33mQlg5DJY1W1tb8GVzdvZ2uHX7lniPR1JyEtg2c3LKvGB4zA8u7pXTWxCED7ThcwyT6cTj8cbfBUEQfTd/536C8HMfgRqUH6Nd8Hfuz/qmkMvF4hUf/ztukr8jUn8VTsw0Vm52Xpxx83IhOyg+ztk3V1y5ksI/isTVU1a6vwrXinH/uynAMvW5GfCyflpaulhl4hsN2VBxkjpr9mxwZZkrVNZW1mC55P6CIIgrCBxccWDLcstGih0An+dx2Jmxs2DHzoEOBxh8jOWcnR7/KBwbT3bknFzw8jYHRdy/3CDyfvnGjpyTlTBasWCHyY5PRoaOnSBXZHhFgcfgIIL7MA6MExt2/v5nbmyY5XLZh8ut+DpVNaXyFyjwEjxXUrkixfPmjX9IjhOfCd9/LwZAfIxpzvRgnnAFjytKPEdOrsxMzT5cCiMIAhjmnNlzwEEZB728CsCBAicOXHnlCiM7rebNmoOdE7cRBHYdv0DtwxeWi5TkZFEueBUkl4IrnhvLAy99M65ccRUEQXRUTHN2eB8A/AU7jMOnw3KSevXaNXBljxMlDraYDlzNZ/pyEYZli2WZk12m98cwPgfzc+dZLhkmw2Z5ZPpl52SjapUqYBnnyiyPx30/B5ODC0cnR8TExuDp0ydiEMGBNifYfAkB05qrx3y5DMNgPDnwE4Rf5yG3+yM2xp+3T2FzoM1+ixMtpkFWZpYoGxGREeKKCQeon/b5dA4Ml7dP2zF9+Npu5hHbDg54uR2PybLMiRgncRxwOVd2BtsdphfbgU9hlX9nmHz5B/9qMQfYNjY24kpT+XmGX77PnyxLrANysj38/c/auGrMSSjbY15p4nmWj80ypVRTQ2ZmhkhrtjcChYScWLIssnyzLHIBgvH+dE6ffme4LFusE5xs8OoM22fmKVeteQWTZZ0DZidHB3H1uW27duIvfnPVeuy4cZBKpOKP2/HYDI83PseXanJM07lzZ7Dt56CaecfnGA9OINjuCYIg/n6LVCr97KWU+Itf7H/YjzEafL8Cz4UvA+MEjenEtpgTy/J4TRAE6Ojqwprki4tDNtY2yM3JFefIyRj7Rl45FAQBoORPEAQGDV7t5LHS0tLEK044wDc3NxPPCULZ7zFwYYFpx/xgPJjm3If9BcPmK1Osra3Bx1gG2HcwXXnlWQREb4JQNh7t/u3+P5Mw/O1w/FMQEgRBVHAejA0gZ54yCjRYWfkYCwEzlgMxzmD5mlu+0ZDPVWwVFPhXKMAyxf3YqXIAxY6oW/du4GVirrbyddlDhgwRb9h8+eIF+PIVNowHDx4EOxDul56RLhp7drZcEeeAhp01yylXcDmgYVnleyE4oOebO7niwpVEvuabK9tcGeQqLwfJQwYPFn8P5GMDxjiWb1x15eokBwAcqPLlDuwM69WtC04SeBWDcTh+/Di6dukiVjA5sOZAgYOLcjh/1ic7vDq164jL0hxUZ2VmolnTpuBLNPh6a3bifG/ClatXxetdW7ZsCa76HSP8b966hV27d4ODIL5mmhMlpiUHCkxjvhSD58/OiL8zPX7cskW8rIlhPn3yVHyyFTuf4SNGiNc0830kXD3lSzL40iO+t6R///7ipS1MI6ZLuVzwPge9fF1tvXr1xGoxB9kMu1rVqmC6Mr15DocPHwYHE5wwckLB59gxMYy/w8YyzZeZcDBy+NAh5BcUgOWbEzW+H4MdJxdjDtK5R48eiZVPtsN8WRg71vI5CIJQvgtOknlVhQP5Dwdph+nHtpodO1/KsnHjBnFlbUD/ASJc1iku+nDARs0/2H3eZzw40GD5P7D/APiBAEOGDAVfhsIBrypV2/neC27DK3Pdu3cXnw4WGhoCc3NzCMLP+DG8P3tjWeCKPlePe/fqBa6+s87yvS+cKHFCEBoSCnMLCzFp+BQ/DtLjE+LBydXH55im/J2LFyxzLF+8grVo0ULxkq9QKh5w4Mn3mzx8+BAs58xfXt1o0bwFWN5btWoF5gvDKYfH+xxkbdy4UTzXrVtXcHWcacwBFtsZbvO5jeWGdZED58+d/yOOcXDOl7Bwws+0ZX1k2+rv/xpMCw4MGzduAi4obli/Hq6uLuCCTG5eLtgec1s+xyVSrq0AABAASURBVFcxcEDJNMzMyvwsqqwrfBkeF2G40MCroGxrmda8YsS2g1eFmb/85LV27dqLlx2xDW/dujX4l4Pd3dxEe8RteIWHbRXTmnHn/nyc/QDbdE6CebWBx2K94dWePn36iPrBvolpzQnRZ5H9iw5y0sjJwUOyGVxkWLhggbiSxbaUbTzfS8X+khMHDvBZb3nVqgslSbdu3hQfIML3APHlV2zfPdw8xAIRz5WnZEmrnRwDMt04weakgWmzb/8+MQmWCBJxPIbJ9ORP5jP71fbED76siW3yxk0bwavvbC/48slM8kPsr9mHODs7g1dw2J/zCk4l50o89N9y+59PGDjbZ6PGzokdbrmgcJXjx80/gh0LL30OHz5cvKaTuciVwoVkKDl75O8VWwUFfi8FuMLJVX/up1SqiZexqKuro26duuCbrjhoXbtmjXh5HC8bs5GqT0EjBy0cCLLR4c9rV6+J11Oy42JZZofN8szGj42gLlVS2HnwjV9s+Dho5oSBN74RmI0syzbfpFXuzBmn8o1hsrNnY8vHGCYbN3bknLxwAMWVedaTdlTZ4sSHkxWe28hRo8RLlTjIZgfH82MYf+bGSQoHiDxfK2srsbLNiQ3rO2/sAJgOvALANOIAlvV64oQJ0NLUBBv8KVOmiKs7XPXkQIydFF/3zkEk04evj+dAi/nBFWyuWvGNdBKpBExXbstBDePClVi+vIAvu5BI/tH88uoF31DJMJhOjAs7Ox6HnR0HGezYmWcc1HJiyZf1sDzx5U4cBLNz19bWgjXNl2H8VRvbUHaQPD4nuCw7LC8sn6NGjgTLMMszB9pcPeVqJ0Un4Cd5sczzPLkv3yTIn7yxjPHloDxPphUnUkrSGz7HG9/Uz3QQBAGsEyybmppaYFllmnObjzfmASeDrSiY5WCI9YZxYnnn4Jpllm/qZ9ngc9999x1409HREYNivrSPA4Lo6Biw7n0M+8/a56owrxayjLEOs+ywvHCiyjfZM305SWW6C4IArlDzDxGyPH6KI8u7VCJFSHCIeIppwvaD58b7XD1nvmlra4vz79Wrt3hDLCd7PA7zXNQnfX2wbDK/RECfvLFe8MaHmZYsvywbkydNBtOa6c+4sxxwG974B9m4sMH7HMBxcMa6xN//rE0QBHH1ULTH9euD7Rrrvq6uHurWrScmYZwg9OvXH9okI5z4sDx9O+pbjKNqP9tglkm2nyyPrMMuL10+oM+8YV4yLZg/rDPl9pSLGSyTbKO4QMH0W7JkiVio4ZuvmYblgDgha9K4scgD7sd85VUm7s84M0y2a1z8ZD3iy5i4gMEwWP/Y/zBs1gumNSctbO/K4f9dPgVBANNx5YoVoq+sUbMmmB8sN7z6ynLEdoRlkotHPHe2+ewP+BImlmm2O2zbeb9Dxw5gmWK7wHNkWEwfTmpZTjnAZ1r26tlL/KE17uNMAT/fI8FjssyzHvB4derWERMBtkNWllaiX2dfam9vDz7GOsr2g4vTzOsrV67C1MwMrL889t9x+0eP9XfE8g/EiQWKgx12aGzc2OjycKywvXr1Eit/zFg2VMxUPsfOql3bdmBHw98rtgoK/F4KcCDIBob7cUDDDoQNGcsWO+hyp8KGi50GGxXe+DGRfJ4NPjtQrnKW3/zG5/kYw2H5ZcPH1/6yoeN9hskOgI0cG0F2ABz8sJPnwIhx+XRj/WA5V6Nldj7HfdigMZ7ssLg/BxMMTxAE8fIaHofH4z7sbPh6Xzba7KwYxp+9cRGAq/hjx4wVg1SmKTtHdjRSqZQcfV3xWlZ21NoUCPF5dpzsTDkYZ14xzhz8Ml35OensIJjW3IadEPfhQJVtCNOGHT/zg50Rj8/9eePxOODiII+/f7oxjXilh3nI57gtL6kzTA4Ambb8NA126Jy48f0sjAPzgT+5Ha8qcZVTT0+fQfxlGxdW2LkyAuxEuXrJ9pU/GVfGmS9J4nnp6emB58XHOMBhW8tzZEf+4uVLlF9OwFU+pjPTkeWag0s9Sop5DN5YN6xpyZ/3mZecfDFMlj+mDR//eBMEQUy4OQBjHjJ+rA/MX24nCGXnOegr1xuWbeYDj8Vt+LIQbs96yt//yO1zsJl2LMtMM54jV6+dKYjh+TD9ef79+vUD6zIfYxoyrkzDT+GVw2IZ4svtuD3ThnnJ7bVIP1jveb7MHy4MsJyzzDJ9WH75PNOHdUEQhE+HEL+zXDMe/IVlnW0I24tynnF/5pkg/Nyf7SUnzNyHL+vj8XkM/v5nbUwDth08Z97K7THrIssF488byzjPoQmtNgiCINKeZZV5wXNle8myxnaJL3HjijPPwc7OTgyAmY/chqvWPE+GX25vPuZdOa1ZFrkPw+BNEAQxgGYceeNxmVZMY+7DMHl8tnl8jgNo5h3D4H3GndszLE4WWLY4TuLvf6eN5ZPtLyfDPE/mB9OX/RnrBM+DbTDPl9tygM4yxHxkmvHcmVfMM54XFyBYZ3ifN/az3I6fkserd9yXx2G7wueYZmyfy20O+1cek2nM53gchsl4MS+Z/oIggP0Lw+FiFseXvLrg4eEuJiHqSnUe+m+5/c8nDH9LrlQgVUGBL6AAB1az58wRq1pf0PwvacKGmFdMOOAQhJ+d/1+CzL85KAeoS5cuRZXKlf/yS09+bSrspNgxcXLDzv/X2v03HBcEQXw0b38Kdv+ucxEEQawyc/WYZf2/ga6/hSPLD1+GwpcXcQLwW23/ynMcNPOqBge9fyUe/+7YXIDhpIvp/u/C+qP6c0LPK6acJP5RY/xd4bIOcJLBCQInTf9hPD+A42SeL69s3KjR39a3MLIVCQNToWKroMB/IQW4emFD1VSuRP1d0WdHyNVlxvXviuPvwYtXC/7OjpPpzJdccYXt98zr79qWK3IsP3/XhIHpxpVGXqEWhP/uhJjnwhsH4VzRZlni73/HjauyvBryd8Tt9+DEQSjLN3/+nn5/ZlsOZtnuCcL/D/n+vbRjG8Q29Y/UB/bhfDXAHznG753359r/TyQMfN0g33THNxBWbDdRQYMvpMHNinYVslIhAxUyUCEDFTJQIQMVMvDfLQP80BO+/+5zicCXHvufSBj4BiB+igxf681PwajYElFBgwoaVMhAhQz8L8lAxVwr5L1CBipk4H9VBvjhDBwLf2ly8Ll2/xMJAy/z8E2IfIMP31hXsQ0SbzCsoEMFHSpkoEIGKmSgQgYqZKBCBv7LZKAihhn0+2SW723jezI+lwh86bH/iYSBicFJA18HW7HJxWfjV9Chgg4VMlAhAxUyUCEDFTJQIQMVMvD/Xwb+3WSB4+j/mYSBJ1ux/YkUqBiqggIVFKigQAUFKihQQYEKClRQ4P8FBSoShv8XbKyYRAUFKihQQYE/jgIVkCsoUEGBCgpUUOB/mwIVCcP/Nv8rZl9BgQoKVFCgggIVFKigwP8OBSpmWkGBf4kC//GE4d+9C/tfmkVFpwoKVFDgAwUqdPADKf5rdyp4+OexroLWfx6tf89IzJfS39Ohou3/WwqwLPyVk/urx/8r5/7x2P9SwpCTlYF3wSHIySv4ACs/Jxv+Pl64c+sm3F55IyMrRzwXHxOFhMRUlL7X/MzURETHxqG45P0BsdWvv5UUFyOWYGRkZf96o4/OFBXkIjoqGrn5P+P20ekPu8WF+QijOWTl5CI+NhrJ6Zn4MozKQZQiMz0DefmF5Qe+4LMUGWnpKCgs+mzb1ORERMbEo/SzZ/+1gzlZWcjNzUNaShJCI2NQWlKCbDpWVFSIyNAQxCen/y7A+TlZCA4ORmZ2rtivtLQEyYlxSExJh8hjektPSyUeJxCPS8Q2/9JbSSEiwkKQklk2zj+DUZCXg/CwMOQX/vaYLE9x0dFIS8tARETYP51/TmaqOJeiL5TXf4YnEykvJwd5pDvZGSkICg4nnAuRRfrCvxcSHhaM5LTMfwqmvEFCTCQSkkm/6EAh0cDf1wt379zCSzcPpGWW6WAu6WvAGz+4ubnBlTYf39dIITksJV5Rt1/+07G0lETExCeh5DNzZvnJIvkpLPq8DP8S2H/mW2lJMclsJgqLS5CeFI8Y0pEU+owmHP8zI/znoKQlJyAqOo5kvxTFhQUICXqLhKQ0ZjvysjNEu5mRkY6ggDciP9w9PBAaHonC9zaB5TM8JBAP79/Fk6cvkEB69XuxKykuBMt4xnsdFfuTnsaSvEfHJaOosLBM3ojX4rlfecvPyUBIGOH2kUoVFeQgMioKeQW/x+6VDVBSVIDw0HBk5eSVHfji91IkJ8QjnvxIFulMdEwsikgWvrR7YUEewkOCEZ/ykV7R3BPJrzx79AAPHjxCWGQ0yXsJosPfiXzx9PKC56tX4n5IeDTJ3u/zDl+K26+1K8zPQ0Zm1q/4pFLkkb/92P/+Gpzfe5x1LSEmmuxDxq+M/Y8QC8mXZmXnkIz/h2jEvImNxL27txEWHf+PA/4JR1LJpwW+C0HBe9kvyM9FSAjHPD/LfSbZSQ93N7h7vIKXl6coK15kW7Nz878Iw6L8bIIZityC4i9qz41iIkKQlJzGu3/4xvarzNd/ub6yb8uhmOo/hVwJ2f5QsqFPn7xAVt6X0fU/NTbDKaJ4MuC1Dx7cu4NnL1woXviZ9qUlRQgPZlv9AA8fPSuTVZLdtOR4sh3u8CD74e3tRXLhijcBJEtFX85nHvvvuP3uhKGUGOjy4AYmfDceL175i3MqJqLePHcUS1auxvlLl7B57Wrs2HsUOaQ45/fvxOUrj1H83pb4Pb6Ig0ePI+sLlSQ3JxNHD+7GK9+ALzJgmYlhOLBrHyJikkXcfu0tOykGa+Ytg09QODHXFW9Do8jg/VrrfzxeQnjt37QdXoGR/3jyV46UZKdh54ZtCAyP/2yLJ/cvYfvR8/jP/Z5iCS7uP4QnL30RHPgad555ICszCSdPnUAkOd9nt2/C603oZ3H5tYNez+5i/NiJePD8FUpIOYrJGd+5cgpXHriITrWktBgvnj3E3mMXiP+/nbT92hh8vDQ3FT+uX4aHniH89Z9u8REB+HHtWsSl/XYgm5udheN79uLFCx88fngPXgHhvwk7wOcZ9p+8iOzC32z2xScLiV53SUfcPAKQFB2ESzfuISQwAGdOXEF2Tj4e3LkB/5CYL4RXigvHduLCnacoIOdzaPsGzF64DBevXMXW9WuweOlGpFAiEuzriVVLVuDIkaM4eeI4NqxbhfU/7kJqRllC8fFgpRRYhgT44YWnP/Hzvbf8qEFmWiJOsPzEJn109I/dzUyJw6mTxxBJiVT0W0+4uHni/o0z2Hv65h878L8A3dvlAbbtPIAUom1STAjGjBqNXccvI6+wGN5Pb2HZmh/hR45k7bJl2H/oMA7s3YNli5fgmZsPSihBc3l4EQsWLcapM+ewd9cWTJ21CCGRn7cXv4ZeUXYKTh/YB++PbVNpEdwf3YWLVwCC/Lxx4dxtSloLfw2EeDzqnQdWbtqOjALxq/iWHhuEHbviDU/sAAAQAElEQVR2IzwuVfz+u95yUsk3/AifwKjf1Q0oxu0LZ3Dq/BP4uj7E3iMnkEG68qVAosLeYvGCmdi0+/yHLnFhb7Bk7izsPXQMx44cxMIFS+AXGAr/V09x+OABzJ81G4uXr8Xxk6fw5IUX8sojxw8Q/tid1+6PcOD0ZZr5Z8YpysPdq2fw0Cv4Myf/vUMcJHq9fIa3wZFf6A9LSJ7ccOH6XQp8f9v2filmhfnk8w/swu59x8iPJ35pt/9Yu5KiXJw5sg3fjp4E33cJItyU2FCsWLkSgZE/4xMXHoQTx45i26bVmDF7HvYeOIRzl64hiYpRYqd/8pYZ+xZLl69EWELWP2n582nXh7fg9zb4i2Khn3v9a3tcMLh64zoiE1K+GMD9M2dw597LL27/zxpmpSfip80bcPriLeRSke2ftf+PniebeXzfNixcvBLnz1/C3p1bMW3WQryLiAMoWXh0+RimTJuBE2fO4viRPZg6fQpc/aOoEBuAc6ePY/2qZZgwcToOkJ2/cfcJfl9x+T86k/8YsN+dMHBlw40MSgpVXo+fuSoatLTEGFy6ehddBo3GurXr8P2YkQh++4YCoBykxsYgLTUDwvuRiigQjKNqUUlBNp4+uIXg2F86nizKzi6dPoF9h47ALzgaxbTCEBcfT6sZuQD1uXbxDA4fPUWGpEyRE2NCcfTAfly+cZ8YUoDikgJEBb/Dg9vXiVFHERZTpuAZBPfM8SM4ePg4IuKSQCU9RL4LQ2ZOIcwtLGGkqwVBKMHL+7dw4OBh+JLz4IC4nNIZqQk4Q0HLwcNHKeCPRViANw4dPYhrN28jPa8Igf5e2L1zN27cfvKhKhHs7Y79+/aSo7tCmWk63rg/xv6DB8kBuSGXqnzuz+9jJ/V5TsFCEcVmGempCKTK4xkKyC5SIJnDqyQUwEWHBuDQ+zlSM2RkpMLL0xWXzx7HkeOnkZCaKaKZHBGCk4cP4tCxk3hHQUZGdADNZS9u3r0PKDRRxd4Kfq4PsO/gEQq6XsPMxg4mhnpIjIsR53bo+FnEpWYhNysNL589QVxSugj3wxvR9vqFM0jOTMf9Ry+QTQlhKSUNabR6kZGVi1LKdOifEoUsRBONi2k140Pff7KTlhCDc2R89+w/iFevA8lZlSAqMgJp2fkozM3Gc+LL7j374PU2RIQUTVXYIxQUnTx3BalUSS/Kz0FcRAQeXLuE48ePIzgyFqXUMj83A9cvnCWanEZsciYFZcVIjI5BRmYebGxtYaKvjSJKeF0e3cPu3bvh/vod9fr5P5eqrG/e+OAc8eTUhevIfR84hAe9wYF9e3D+6h1k5RbSylESXF2e4taNyzh55gLik8rkOp3mdfbYEew/fAyhscnISovH8cP7KVG4g2KpElUcbUnmruPI0aMUsLyDo4MTyaImEmMjcIx4eeTEaYRTv+K8dDwhGoTFl8EtxzA5PhbJqelwf3gdPx27ignzlmL1ylVYNn86/B6exY5jt5BO8qGqbo5p02dh8eIlGD9qKLxdHiIiPgUpcWF47uKCnPcrZYIgQEffEDYWJkiJDYMrVdDOEj0vXrsp6tcrFwpkyDG6e70Vq7wu925iH/HM520o0bYUUSFvcfvuLZwmA5uRkwuPx/dx+NBRqpY/RVB4LDKSouD9+i0KqIIQS6spbp5vAJLxIF8vHNq/F4dPnEV0Yioltil48fghrl44TwWGEzhw5CjJsQsUWkawItzSk5MQm5RCYxbjrbcb6dk+PHrpXU6WD58+pCc3Ll3ElZuPRPyf3bmOPXv24M7jl+JKX1JcBF48f4JTJ47h7JU7ou4WF+bB9el90pOjePDsJd6FRZBdKUGovw85jZ9w8/4TZOcVorQwB3fv3kPUR8GziZExIokGCclp8HF7jEhazQqgfskZWXjx9C4k6iaQ8eqMoIMZ02diyeJFqGSuxKOnT5GfEY8F81fBuUkXrKTkd/OmVSiM9cX1u66UXIbg/uOnyC0um1o22d+nz58hI7eAqu+x8PTyovkUIoF49so/iFZl4+Hj+hSHDhzAE5dXNC8JTK3tYGakjfvXz+LYydNkI+KQn5eLa6TTR0j3Ez6uwNMwvGoXRIWGyxfO4cLVm8jLy0cRrRLERMfSqlgxEqLe4dD+3Th/5RZS0rOpB5BNCeW5k0dw8uxlpGXlicdSSEbPnzpFTvcmwqhan/2x4yf7EUOB1/EjB3Hx2n2aQymKC/Lx6tlD7KLE5Km7nwgjLSEBiQlpyM7MQHxCEkpoBfLZg9vYs3cvnrh6IZ8MqPcrNzx39wflXWIffiuh1RYfD3fERsXh4fVTCE7OpcOleEHFAr+4EmzatAHryLE7GGvhwUsftOg8AMsWzUNde3s0adMLSxYtRP+erREV5o8XHv7U96N/ChqeMw4kT3epwlhANr0gPx/3b13DPtIRn8BwFBOvA9/6UIXyJuG6nwo0wSKAgpxM3L18gWRxL+49daWEpAihwW/xiFboTxGtDh45Srb9FPwCYpCalICL505jz7798HzzDglx0WLSfoZ0LDE1D3FRETh+6ADOXb6J3CIR/Ie34qJCuD17hH2UmF69/QBFpGtJ8dFwffkSp44eJpo/QID/Gxw9cpiSyTcQJFIYW1jBQFMVfn6+ePn4EY4cOgSXV74oolUd5r/rE9KNvfvx6k0oCvPzcJds3pGTZ/CWAlkvz1e4RPN6QHMqyMvCrSs0R2r7wt2b+hcjMjgATx89IRt4CLcePhfxzM5Iw53rl7F77wF4kx0JD/bHrccusK3bGrWrOCKMChgHyI/efeJK7UuRSqt4T8g/HT92VGwf8dYPR2n+R06eI/+VTeakCH6eL7Cf5nzt1kOybQXUD/D3cCEf/RPptCs4gS+gBPbmrXtITM4Sz5e/xUeG4YWbP4TsGJy6dEWMcQqJr+Hkj3LzC8qbwbZaPSxcshRDvuoLK8eqmD1nLmZOHgelpBBPnz+nADf/Q1veCfX3xgHyMcfJP8RSEF5Cch4WEY48kt04GvMU+Yl9pK9vg0luqLD02tsDT4hWh/cTXYjvXFAws7aHvo4WQkOC4PLyCQ6TD2S65BaUMf6N10vsJT/5wt2H6F3Cw37Y8jNScPXsSTGxcfMNRBH553eBfnhMvo/5701j+Lk+ovjqBMKiEqBQUYGTvQM05MDr16/x8t5t8pF74UX2hXWskGK5i2eO4/CxU4iOTUR+ahTZ+r1ka29TwhkCN4oTTx88AI/X7xBHtv4kydt+iq3ehkShIC8bvn5eePzwNg4dPkJ8DCMbW4q05Fgqnh0m+3EJKRQ3+jy+BTefADRp3gI6Gko8f3ATe/cdgj8VehmHcIqN7t24SrblCpKpSOP65C7Nfw9uP3hCtqQQhUTjh3dviPro4R8q0qIgNwsPKT7cuWsv/N9F0rEShAf54JmHDz6m2JsX17Hhp+PoN3IyVq5ZjU0/rEdJcgiu3n6O2FBfzFn2A5p1/xrr1qzC+g1r4axVQD7jCOyqNcSseYsxpH1zKFVNsXTFCnw3vD9KcpNw/fZDpGfl05j/nf/vw/gvRz41MQpvIjIxdcr3eON6D36hiVBqaMPJwQIHfvoRR05cQqlSnxzfHOjpaoOF3MvLFefPXcSFS1dx77kPKaAExXmZZEzOwT+iLKAHvYqpsrBkwVScufEQriQo48ePR2JBKVQUchTlpGPJzEnYtOcsnty7jkUr18Hf3x0jhg8lQ++OQ9vWYcGaPRQkyhAfF0TLzI9x7+wRMSMMpARi6aJZuPLgObxfPMDcWQsQHJ0MqUwGCYpwn4y+b1AwTu1cgemLN8DD9QXmzJyPgLB4wgpgw7KZqt1nbjxDoK8rtmz+UTyXWZADvhznxb2bWDB3Od7Rcvue7Wuwfe8ReL64je9nzUNoZBwunNyLrXsOiwF4VkEmkpNicWLPVkydtx6hYSEU4C3ERTLmKnIJPB9cx+1HT7F17XIcu+6CqNC3mDNtDl6SAdizZRUWrf8JvEQ2fcoUXH3kgqf3LmPp6h8o0fDFxGkT8YAc5pO717Bs1QaERacig4x2amoiGXxXXLh1HxkZaUhLz0BKSgxuUcLx8Jk7tm1dTWO+xONrJ7F05Q/IpMTl7p3bFFAmi/Mvf4sJ9sVjnyjKmiciKcyPArsUQABKKKnzcnuGKxfKePzsqRuKqaIq8EnQi4KCEjJOn250RvxPo9WeVSuX4uZzD4RSIjZ/0VJ4h8ZAIpFCLpPg4sl9WLt1L4LeemPid+PJWZ7B/AVz4OoXiDun92PxsvXIKpIjPPANzly8ihsXL2D5ivVISU3BkhmjsefEBTy7fRnDho6iym8u5HIZOZVCXLpyDi99gnDr8ims/GE7rcIEYNrokbjn4i/ixW8yqZRk8T5evHiKLeuWYdWOk3jr8QLzZi7A68AQXDy6A+u27kFE2BsM++ZbHDl7C7eunceyDTsokE/BtCnjceOxC57fu4KRE2cjNT0TGVkZSKbAKuiNO/afvoC45AxKepLpXCouXTqNZ+6vwPS47/Ia3s9uYvvOfUhISMINwtc/MgUfvwRBAJGXnIcr6rbrjo4NqkNLSwv2NRvh2+G9cP/aWeRQ4J6dmYx3pAeBAW8R4PcaClUt6GqrUXL9hipCjyjpyRfBltIK0WtfNzz2eA1/t3sY2u8rXLv3FFvJKO47fQN5JPPp6SRD5HyO71yDWat/hD+tYCyaMQt+lOC7PjyPyeOm4OaNBzh/+Cd8P2cZPMlRTx0/ERfvuCDC7yl2HzlNclkMLwreWZ9fe73EohWrEEzB5K3zh7Fy43ZEUVV45Oix2LbvKNxpmT8tLQ1xVGh443of9+4/R6kgIbuggPfTB6TPS+FHQc/SeVOw69QtlIoz4bdS7P1pI2YsXo2X3t44vm8jFqzdhjAKWpYtXYx7rj4IffMC31Al8e7jZ1i7bB42H7iCh7cuY+XazQigRHHW99/iIPHI8/kdfDtxCt6QMz+640fsOXQR+fnpOH/xIul4Ig8mbsY2DjDQkiMyMprsigsGj5kME5UivPX1h7tfJJq3bgaFQoaM9GQK8j0pcHuBoNAEmFraIML7HtKluujbpy/0tbWha2iLg6fOYUjvVogJ8cfFa7dJzsVhUJyThs1U8XzoEYgndy9h6uxF4FXDiwe34+ELL2qUib37T8LXywtrly6F6ytvvLx5AbcfuIMv70zOSCI9T8L6mZNxkFa3nt2/jJHjpyE2NZf6lv2rqqohgILte3du4dDubZi34TBKFCqQE/4RbzwwdPAoWol6K9q35bRilUCJwZgR3+Ds1Ye4dv4gRkxdgAQq9mxaswxnKKm4fuMCPPzfQo30D+9fCVFBmDVlJh49d8euTQuxYvsh3Lh0EitIH8MjwrBq+mScvPgEEGQQBIE+BfoE7l46gnmrtiAuNho7fvwBHj5vKEB5gLuPPcCBBN6/crIy4eLqid7fjEU1gyIcP3VFPG/n6ISijHDMW7wezz0D0eebMRjRg2xkCAAAEABJREFUtxNUVJXQVNeAmlQGGeGpTXxQqsmJjm6UsL16D5U+KPC+cGAz5i7djJCgQKxfsQTXn7/B/Qu7sWnHfrwmnzeb/ExCSgqO7P8Jy8huBwf5YcL48WRfvCmY3UaryRcQHxNO9n85JbseeHT7HIaMnohLdx4gNCoamZnpiIoKx/b1K3DlxmMEej7B5AmT8IqC6qysbCQlJiLynR+tjswW+5/ZtQnT561FJhUwCEPx/+WNE1i5ZgtCgkOwev5U7DpzH/6utzF18lQ8dX2FdUtmYvSkGXh4/wamTpqC1xFppFP34OvthcM/zMO46Yvx/NEDLFm0BAERcbh5ZhcWrloHP28PTBo5jHyQFzKJxqlpaWA7vn3VFKxcvRk+tIq2dcU8/LDzJK1AvMLiRQvxKjAanrcPYcK0uXj67AUWTv0e5+57UeFrP9mEM2S/vTGfgm7P1wEUUOYgKTUB7k9vYvaCRfD2eY2NC6Zj497LCPZ7jgWzpuHc+ct4+uAe2Y6l8PANxJkDxI8lq+Hm8gzLl69BRFQU9v+0QYwnHt84i/Ezye+HRmAXBXfHz91GbmYiOOmKTkgXacVvpcTX16/9oGLsTGOMx1PyDSEUK/A5QRD448Mmkyugra0FdQ01yGQyaJPd1dLURCoViW7dvks2Ne9DW3/i3XcTpxENo3D1/HGs3b4fgkQCqUSCzMRIrFmyCE9f+eONxxMsWLAYwVExWDNjJGaTfD6mOc4n/U5IScXTa6fgSnbryN6tGDt5Abx8fbFuxRI8fOmF5xePYOy4OXj95g1Wr1iESw/cPoxfQPZi+aLp2Ef+yc/zJRYumIdQKj6dPbKVgtuleHTvBob06Yqla/bh6sWz2LhjHxLT0nGMEozAt6/x44o5WPLDQbz2cMGKJcvh6emJqWPYt97A0/s3MJ18dmBILNIpGE9NTyJ/9AgjR43GPrKdL92eY/HK5XDzC4Sn20MsWbYc/iHhWDjje8xZsRUPKX5aTDCjE1OwdMoYXLz1CHeunsaqnYeREJdMRYI8JCXFYd+aRZi3dCv8fF5h/vy5eBMSSf7tBL6fMgO3nj7H8T2bsWDJJoSHBWP14vm489IXT26dwKpN2+BP+rhk3hwExmbgzJ4d2LH7OMIoQZ8wfjSeeLxFkK+7mKQWf6AYcP3aFdjWboN+XZpARS6lBEyGNZu3oV/X5iSXT6Fm6oxx3/aDUqmG4mIZvp+/HtPHDoKqQkE+WBsa9CmXKqCmqQMNdSVS4kOpkHaV/HzuR6P8d+1Kfi+6L+5dQkhMAgWEhSjNjMH+4xcgU2pjyMjvMKJ/B4T4u2ANOeMNP/yE1MwcUgogIT4Sb/x94f/aF+FRiSguKoZM0wRzl/+AjnXtP6DAhr5a7YZo3rQBKjvaIYWEJTa5FAq5DFFhAXj6IhTLyRitXr0Sg3p3xq1zJyE1qISNGzdh4fSxcL1zCVGJ6TCxdMBEqqYuXTYfhWmhcKcEIClXimXLlmHx8uUwUcmBt3/Ah3ELCgqQRVXyC1ce45spi7Bm1QpM/m4IlGoKsU0pRWSlIFIJpTCyroImjRugWmVnVLeohC49eiMqwAs5RQJq1KiG6s62cHnxAlmFCrTr2Ak1qtrB0syEqpAZqFK9DmrZVkOjejXg8coXQ8bOxvJlS9CvS2s8I4dZUFSKqg3bY8OGjejfqTXCQ6LhRhXasJgU1KpTGw1qOeP+7RuITEyDTdV6FDQvxNLFi5CdEk4OJgGNm7dF00Y1YWtlgSSqYGiYOKJp5Zpo0qgVjKhMkJyRh1qNm6JRw4Zo0rQhCqmKkc+VUpobz7FavaZo3qgWNI0sxSXWOs424vzFNzKkty+dQnx2CVCYi6SYdzh59TEE+uOINS4mihI4P+KxH6Kogl9MCQKf4r7p6Sl49uQJ7t+/jwcP7uPevXvESw8KuAr5NKTknGvVaYCmTevDysoa+VSZTM3IBihhKM5Ng4f3W/Qb+i1WrVmL+VNGID7YG6oW1bFk0UIsX74YufGBeBMQBB1jE8xfvhozp42HijQX0cFeeOoTLQaMGzeuhUFpLG5QgiQluIxzbm4u8mjzpmCq7+CRJFtrsWDeFBhqqop48VsxJUN1m3aiStIajO7ZAYGUJPh5vERyfhGqVq2GmlUdEUABb2hUPHTNHbF0xUrMnjIOGXHBiEpOReOmLdCkSUPYWVsh4l0UNIwt0KheY3Rs3gb6NE5mVi5qN2iEZnVbomHN2kjPSEcBySMkMoDkzbZqAzSoXQ3qeqZYsOIHtK9li09fpVQXycsuhoaa2i9O6erp0XfSUwqhE+JCKWG/gHXL5mLDjoPoM2gwzPR1SN7aYdbUSTDQVqe29F8KFBUWIL+gEFxhdnKuhVUb1mNwnzYIDH2H6vVaoXHjxmhQ3RKnaHXH2KEG6tSuDqk0G/dfBqCEKl2duvXDutVz8eTOA3QaPAariEftWjYjmMUoLi6i+RFONE4xVX9Z/jQ0tdCyTRtUruIEW0sLxMcmiUGImqE11mzbjeUzJ6J+vfro06s91OXFlADlQRAEQrQIdy6dRYFSi/SjHhyNVcV7qDILaR7v/wupejf4u6lYNG0MrK3s0K1Hd1RysoeClsOiY1NRQlXius3aE9/W4+uOLUiGA+BB/G3XewDZixUYNaQHuJBx59YN5Ct00bhBbZhZGpOOP6VqrjrWr12DRnXs348GqKhpw9rcBH4ujxFExZA2XXrCTE8Fbi/uISVfJvJSIilFJgXsT549w8OnTxCXmEo6nC7OWV1DheyOCj68xEC5FJUbdSAnOAf6ZSYJWoamqFfdHHev34K/XwgyCIYnBfcer0NQneRShYKZMRSIL1qyCPWrWyOZCj35eTlUxZOgbv2maNusEyyJZxdv34Nj9ZqoW6sa4v2fw+1txIeh82nlzbZGfSxesQbzJ4+E57M7SEgrhISq+w/v34O2Q2Ns3LAOMyeNRQIVNi6eP4vITBWsXL+RAuiFyAz1xJlrjxCZVIBps+dh7crFsDQxpNWA4g9jvH32EHI9Byxatgob169DDTs9PHr4AHJtU1SvXgNWNtp45vIS+VS9J46X9SPZKSH+ycmJyxRKtGzZEsa0Ujhs1CTMHD8AVGMoa0fvnJC4ub1CNlWINZSquHruFGJopdGpdhPCZz4sDBQ4fXgX5s+ei3tiBRukLaW00SeNQyDoX45efYdg2rj+tP/+n3yCjokdevbuBGdnR0qCShAbG44S6iNIBBiZ26JLh9YQSDchU8WQb0ZjGdGxfW0TPH7+Atb2ldChYxtYWltDlexReloGcrMzUKttX+za8iMliV1Ru35ztGpcHZVq1EGTpnXh6FwNhZkxkKmoom7d2ug1YAgyY/wo+IpB9Vp1ULdxHTy7ewMRpD/vsYSqrhnadGhFvqcq2RsVRBCfimg1sU6T9uDArWu7OqhJ+6uoCmqhkY+omAgU0apIIdmArLR8DBo9FUuXLoSztQ4lwSG4duUGeg35Dut/2Ih+zZ0paL+K2g0ao0WrtoSTEyhexMRZyzD22yGwdq6J7t3bwt7BHpKiLKQkx6GooBhtO/bEuh82o03DSmRPfYjWEhChoGdqgy6d2qNmrbqoUacORgwfhnceD5BItq0m6b+TszVuXrqEVFoxdarSBFt3/IS+3VqgQaOmqFWzMio72CA4KAoZuaWQkX0oLJWhTbtOsKVVtdukv6oG5qhXtyYM6PvL588gKM2xZdNqVHMyRfkrn1azX1ABMTM7G+l5EmTHhuABrZZIJBJCUQAILj59kW+kSXw4al+lFhUxZsJAR+vDMTWlJjp26YHaNZ1hYmCIuNgUlBA4biCRylG7cTPUq1MDtnZ2KMhKRHJ6OsmSGr6dMAtLF82Cub4EmcSTQlpJZ/+QUyRB/2FjsHzJErSpV414E4eTR09BrmOERvVrw1BThqs37jJ4cSuFAOca9dG+bTM42FqjIDsXsclFKIEUnfoMwYr502CkqcQ3MxZh2vffIS8tC2npOWAfmU+6o6qqg5mLl2ARxU+2JipwfXoDbkFZWLd5C5ZRcK5ChdCg5AK0q9sQjeu3gIWOGvRsa+DoyVPo16ElGjRoSDamMpydHJFJsBOTMpBbqsTkGQuxeM4MGJAux6bkku4KkAgyktc6aFSrOpq1b0k2txGaNayK82cuw5ZsW7061alan4z7L15DIpWhY7/hZG+WoGb1KmjXtRON4QBd1RJExsWiiIgsSFRhQDFhhw7tIclLwZ07D2FkYYHa9RpAR5aDJ8/d0KzLEMwd9zXk+PmVmZUFXQMdSOiQn9sTrKOi2Soq0ly/cxfJaTnQ0TAEW+qYiGD8tH0z6fdKbNl7jla0yhwQ24JS6kumgt5B+tAY2zcug6Wptvj9v/GNafHFeJfkJVPQcRuGJmaIjk9CnXo18ezmRXj6vMbVyzfQuttg0QgtmDEGsYEvEUkZqowY2rpND8yYNRuzZs7E4B4toJAJon4p1dVpX/ph/Bxyog/vPqCqexQEqRRSuZxipjKt4qVeiUwN+kZ6UGpoErO0kENGVqmtB00NVejp6UBWWkQV0CKoqmpDS1MDClUl1OlcES3LivsqciioQqatriYGLRAE8IuNQQktteeT4puYmUFJ2aCRkS4FN8V8moRSgTZtO6BNg6qIjwjEzZs3EUPZsCAIkEklKMgvoD5atC+FuY0T6tWtjtiId3j5wh1xCanimFIyChJqzwD5s6RUCgNDA8hlMmhr65CRLkQpnden8TWVqlBXUUJBjbNJaOWqmlBRyGFu7UTJVEPal0FLTx8aKgrI1bShJpdRkBWBp7QyER4ZL9JNJpODxxFKSyEhYyeRCOKnIAgQJBJIpFKavgRyhQLt2rRHNUdrRAa+xrlzZxCXlgtVCj55bnj/ykqOwKVbz1CtVi2qdifAnIKiGxfOIiktDyqqKmjTuRemzZyFmTOno1evLnRMDg7KuXt+Xi4iwsPEm6WDqdLFW1hENIooGOfzaSnJFIC9RFhYOCBVQEE4CYIEAp0sId6VUOCsq0f0lavBzMwIhbScqaGpDQXJh6quMSUHUhRQMKSjZwB9XT0aWxUqtJxaSMkA00GHjmnSpk10zSF6QmDIANNFQCmtMQG6utqQEx3NTIwhlZSUo06fpSRzRGuSJ211TcgkUmRn5xO/NWl8KYzMbMgY1oVcKoEOBegGhjoU8KnRHOSIpirzk0ePqdIVA5AeyAlfpr1A85JSVCORCu9xoLlKiB/EIwECZAo1dO3cGfWczPGOEu1rN27SKkQajakOOfXDR69S2pdQX0sbI/h7eyM5qxCR4SFkFO/hAVXNLWyrQEWugJVNdapuTsB8qgRVd7ZBTEIyBY+lkMrkUFNTheQ9TQgcYSBAEIgyZPFMTM2goVSSHmmKbQSBcBWkFAAUiEGcoZ4h6ZkGatdrBFszXe4OE6KhGslrTlYRdIhPaiRLpsaGYn8p00CEISCV5AI0TlhICNzd3JGYnAE5BV5rMSAAABAASURBVENsM0ppbH0DPZiYGEAmlVIzAXK5BBKSXUEQxHFKSV/TyHBraWlCVUWGqjXro27tKsQz8bT4JpPJYGpiJOLr9uIlvGm1IjuvSBxHIkjENkZ0XkNTHboaWpDSsSIKTjXUlJDJ5LRKqge5RKAkJRfaNBeJRAZLG0fUrVEZcoKtrq4OOeEnAqI31gUHe1vcv3kNBUoL1HEyg4O9JSX616Fu4gwnMx0UFRbBxNyZVp+mYfHiJfjmqy7w8X4OLdvayE1OpOJKAEHi/2KcObhTDLpLBBnUiQ+ECp8AyAl26tQZbk9uIoCqZm2b18KJA9uRWKKPOtVsiQYqsLIwhIxkWqmphEi397QTBAFMUw4GCmllTkdHE1o6hmjdvg20NVTL4NN7SXEJtHV1oKOnC11tLUAoROH7hwrk5BRBi86pq8igQXSRyiRITcuGQkWDaKZJmx7UVBVITE+jwEdK+6rQ1NGFlrYGfWephfjKoYRZqakJDQ2l6FdUSyTIzcuDJiWRUomUgpwGqEFFGAmFNnj/4t7O1Wrjq14dUUwr1U8f3KLVmyBI5So0jsr7VmUfT+9cQ6GKFnKo6mlgVxnFSYF4/NIbD65fRnBCCebOnYe169ejkbMBzly+TNagrN+n7wryG2pk58qPFxXl4RUlha+83ooBgirNFeR/KlVvgK5tmyIvLR6Xzx2Hf3g8VEiWDI11IZcrKIjUQRr5RXcXN/j7+1PyVEo0UyH+SIlnpbCyMid9k0OQSCCVysjW5cKVVjeDQqMgJRxUFVJqK7zXBznRKgdymQrJvwKGZrZo27IJlCpylL9ee72AOxWnsqkwpKYmJ77TGUEOQwpaVcjOKlTVYGFuRLKlDk09TZRQAs1jCwK1k6jDguytnGypOukH6xvLLvNbJlOFsaEe8rKziGYSSCUSCFIJwdcSjxfmZ+Hl00dU7X6HQmKYqqocLLuCoIAR2Ul1pSq0dLQA6l2jVj20b94A2ZRQ3Lh4mhKgaAgSGWQkU9kEX6mmTjZMBgcqfjWjFVSJICV/b0B2VhUJUaF4/syFbEcaVFVVxX5G5jbo2qcPtFRlFNg+wd3bL5CenQddLR1ISWftHSujRhVHgi8F669MKiE8yv6T4yLgRSs4WmpSKowmomZNJ7x8/BhpJO+CIEAqkeKfvaTENyVVnQWBiUgzLClG2LsgPH/hggRK7GUkBzLCg88KAtnBpGi8fOmGsJhYyMk+qpBOlRJdNLQ0YWpsAlWyz2rqaiCmE+8lEAAo1DVgbGpEc5BBU1UdMirE8By1dQ0hkSlQuVotVCW9oabifzatCD9+8AhB7yippSNyhQrFVoCM7K2BkSHUVOSkg6awsdSHmkIV6hKZKI9Scb4C+VNtkgUdyOQyaGgpyYYVQqaqRf5WG2pkl9TUVMgfFBCPJWUb9TMwM4eBlhpSk+Lx8rkLwiJiwOPKCD8CDjV9PRgb6Ynyry5XAGTzOwz4GrWrOdPKrx9OHrlCRZlSMH84DsgpEKBLcY+C5lunXkOybwYolchgZGYCdXkRvNxewM3zDa2w5UGF9LGY4gs7x2ro06kl8lJJHy+eg29gEIohhYZSXaRlvUbNYWdjBplC8Q+2o0qlKnjr6YZgSu7snGtg8JBhcDCQ0+qbB+wcrBER7EWrZpEwMDZHzz79Ub+6NR4+fYHc/CKi8D/+s1yoqyshlQj/ePK/5Ijk9+D54s5leIdkU5a5EpMmTsK6LdugmROBGw+fw9fPDWO+myLey3Dv4WOqsKtCnwxNXm4OOZlSyElI5CRspaWFyKcKanF2Kg7s2IwXb6I+oJBFRvb5s9dwrFKbVjDyEZucgLz8XKoC50HPyAL6ymzsoDFPH91H1YXdqFqvGUK9nmHvsdPYdeAkFMbVYaWvJOeeQ8FoCUqogpmTkwNTE3PkkFLuO3MF1y+fhWtACmwt6BhVEYrIKfIYUg0dVLe1wL4t63HuwgUsWL4BMaTcjFxBTgauXb+O2CINdO3YCqmEVy7BVmrm4frNu9DUNwUbSH0TUyREBiE+OQ1hQe8Ql1KKls2bIj4+lo4lQqauAkGWipeeb2Giq44ju7ZQUHcfl69cgq2tHc25gDL6PNYlcIKUkVMI5yrVRWVQIaWMCQ9EZGIGVFXkeO32EKcv3cS5wz8ht0AKGa0WvPKJQpNmLQmXbMI9HqVCCbT0S+Hyyg0xFIzl5eYBEg3Ex0WRcrkjNzsHWZmZuHnnJuR65mhY0x7hoUFITEjEqePH8Y6SD4ivUjy+fRPhaUps3bIGE4n3K5ctRn7EK5y+9VwMPPlyIzkZO7lMRnQvIr4ViPPg7gZGZug3cBC++eYbfP311xg+/BsM7NOFDL4Kn6Yl3Di8DYhArUatoCErQChf15mfR3zMAsgoGWlr4eL5C7h57QImzV6KXLk+gjye4sq9hzi0cyvislVgRvzMpvnwdZnFZChyiLdGVOHQlxfg4L5dOLBnF1wCM9GwUUOCm00ySThSwEqLOrDQ18H58xdx785VTJs1F54BkRCtMoDioiJwAFOCUhTk5SMrJx/2lasgPysDWhQspyfH4x2vLlAgFOT5HLv3HaKk6xIZJQ1o5SfilVcInGvWIwObg5joSBQUl0Iiy8Nzt5fik6XyaJ5yVSA80geB7wJIbguRkZqIC1TJK9GzQYdWdYkfschKisVRmod7cDxh9fN/PukHV5zad+8FeXoQRn83HscPHsTk70Zi65kH6Nq9K6RSCQoo0DMwMETNek3wzdCBOHVgH9xfhyHstQcOHz+NNArcyqEWUpLG12MXUhKdk5OLEjLkBQX5yKP5S8lAJ9GKoX9EMmpVcqTkJJiMrxpCaPVQqqmBItLtnJwCQK6Fjq3r4PSun3Dq7EVcuXWXwJdCS98EQe4euHT6OPaeOov0nDxEBQUiJVtAowZ1kECwM0i/CiiozibdJfWEjIKa9NQk3Ln9HOmZOSLvuOrFgUhDCpAykxKhrqEObz9/mkc+NOU01Pv/3NwcmnshinIz4f7oGVQNbclBWCA5LhzZVE0sZP6SXlBejXwKVHNphaQ66dyVC5dIbn7Cnr0HkVciQ72aNREfGw2phh5ykmKQRPIF5GLn7j14ExzzfjRSL6kCFpZWiI0JgWO9xlCSIzKzskc8rbrVqFMfKjJqWlqMyLC3OHbiJA5S/5Pnb0KpZQwTq2ro3rQa1iyYh+MnzmHT8tlYv+0A9AwNEfXaHdt2HwQV+AlA2X/1xq0hSX6H1HygDQWpL569hDVVXnUp2MklvjENS2li+SRjXDQpoPnlkTOTygT4+b9AtkIDle3NkJqSDtCqgYtPMPS0VMuA07uc9Nn98R0cO3gI+w6dgImZM4z05GAY9epVw6u7l3D09GWcOXMCJYIK+vfpgIKEAOzauQ+79uxGAvF0SK+20CjJxNnTF3Bg/354vX4tBhQEXvx3oqJTuJ8rLp67gLVLZ+HM7Zewt3NEdnoqzMxMEOj2HFmkM7xgyeMWk2yyvXZ/9hC3XV6jTeeuUEryqeKXirs3LuD0lUckryJo5GXE4dCxyxg4ciKmT5mCGXMW46uuTXDh7Blk5WdiLa18LV65jVY+78HFOwj2tk5las80I5kooFW2MkhFePTgJo6du1v2ld4LSe9ePH8EdUMLVLYzRVRUNNmGIrg9vwfv0Hg0adIAmUmRSM7IRVZaIs6eOY3rtEJ75oYrqllbItDHHxaVG8CBkrqQ8DDxMrECquTmkI6VEhaqSg289nLB/acueEtBTvUaNSHPT8K78ETkFApkXwTcvnoBWnqW0FIqIFCQlxUdgqDYBChUflYAb/cXUNPSg5OlAcLCIpCUmoMi0mvWZZaNPLKBBQVFKKWgNpcKLEVkO1nXWf/zSP+YBqVE/FzSI4lUlRLlKrhAhaJz589g9+lHqNOwFWQUfPp5uyOQVu3zyU4UFhYT/1LwnKr4Vs61YGWojggKFrNz8kl3C0h+ComCpcijIk8RBbp8v1xQfBY60ap6VkoUElIy6Fwe+cIS1KdCRCHJr5q6BiLfeCM2twASlCD3/f1zUaHBiI7NE1ejQomOKVlpCAnwxd27j9GkTTsYkzGITUhCzSpVEB4RCU1dE6TQSlAa0bqkIJniiD0Ie3/JESGFJzcvoVTLBrPmzMcE8nNL1qxAbJAX3L39kZ4QjqMH92DnTzuwa/8RhMckcRcU0xzYRzA9+UBUSCAOHjqKtKxs/gpyiAjx80VcWhGaNG0uXgqVnJyAgqJisJ6mUJISEhOPZo2aUE6ehcjYNLJFhWV+itqUkBHMI96UUIGEi2/ME7ZVzKNS8kt5xMMiqKB5kzpIiouEmoYGwkNDqBDGxqYMhUzyKY8feqFSzUbQVldFVFwMcomuhcSvApLzEkoUc8gWl5Ct5/nkE32KabwcGpd5lEe2o4j0kOeYTbphauUIzbwIbNm6HZcvnhJXtao5OUCpXYxXPp4IT+Q55BN2pUiIjce74CS0aN4S6YRHdEIs2eR8ce5FZH9LSObySO4LC3Nx9shBlKpqo5qzPYJDQolGhUSHXPIBemhY2w7hVFRU11CCi45cIGB65BcUoLQ4F14eLpBpmZI+WiA2jvQkKw8+bo/x8m0kmjZrhOzUeCRnlaCKkzWyqchrYqiBVx6epEtSvH5xH8eu3EVhGbnE9x4DRsJOnoRx4yfj0s3HeHT/Cs7dfAYtEzvUatkJLetYYOyw4Thw5AxePH6A07QCYmpiDBWFVOxfXJgv4l4qfgPiwv2wfvMuKv5lvT/y3/ch+T0oZ+fKMZwCkso2hlBTUyMnbYQZ0yfAxsYaM+YtRv0qRrh54xIiUvIwjZyeGVUgajdvizp1nSEIZSOZO9dDq2ZNyXGWgi9VKaTAoOwMYGZfB4sWjsOTO5fI2cjx3bDe0JTloFHTFqhDhmPN5g0oTvTHC+8QDKbgsxstyS6cMhout64iS6aFTZvmQsvIFM1bt4ahrhY09EzQqXN3VK3TEFMnjUfYq8e4+cgN304ZR4pbF9369YGVqSHq1G6ISvY2mLNsJWrbquLazQfoOfAb1KtsK6KmTkZmYL/+SPR7hgMnrqDPkJGo37gpBowYhuLUcFRv0RG9OzfDiUP7EJOhhq/6DsTgr79G8+r6pFA7YGZbHR2bVIaKtjEGDhuIIkpABnw7Hg0q6eLwwROwqdMeg3p3gqNzTXRo2RACjepcuw7q1bBFzaZt8e2IAbh/9SJCk6SYMmYM9DTUiPZa8Hx6Ex7vUjBmwgTKcPvi++EdcWzfDuSUqKMP4aOikKDToCFUgSglWpijQ/N60NDQR4dmTZCSEI8GtGrSuEEt9OzaDW9cH+KGazDmL1sPB30Bbq6PERYVR5jwfwmkqvr4btxYMsDqIu9NrJwwb+b3kEmKYVulLupUcYCUmCwIEjhSZt66RX0oFGUGSyKRQEVFBaqqqh82FRVyctSeoTtVr42hX3XD5aO74R2YiOFfdSf+6aFz115wtjbDkFFl1cfyAAAQAElEQVRjYKMrwclTF9Bv+ERMmzENY4b0xH0yVG9jMjF99kSqGDmhY4/u0NWQQ9fQBC1atIC2jq5YPSyKC8QTd38sXLcKde1N0aBFSzg52aJli3aoSVWYbl8NR2UzNRw9egbt+49Bz47NITBitJlYVUKbpg2gJpPAvlYddKIAvkGL1hg1pAcunToK75A0DO4/BNqqcugbGCDQ1wNhyTkYO2EsmrTvgvHfDcStcydQKGgRfzohL19A83btIAj5kGuao1fntoRLJQqWq8A/KAztOnRD44aN8FWf7vB+dB3nb7lg5Njv4UyB3eM75xAcHkdY/fxfv1lb1K1WCYaWzth76DCqW6jhdXAE2nbrieG9O+DxnXtQ6hujDS3tqlHVRZBI0ax1J4wd0lVc/WKnkZOdSUFWaRlQ4h9XZepVdYSNcy207dAaCgownarVQfMGtaGlpUVJTHMkUwI6e9V61LVU4MSZi6jUqB1aVLWEbbV6qEdBoEwmxbBJs/BVj3q4RTgUQxVF5PgMbeqgT7eGePzkMVp06Y6+3VugdddeqGmvT8u6u8kG1EbXTo3FJLx3984gdkKHEvJu7dogJvgttKyrolGjuqhauz6a0Upex35D0aN9Q5w+fgJaZjXw3dDBkJQzDwJatumEqo5WUNM1xaxli1EY7YPrt56QbHWChZEmDMwqo1WTumAb70w2plWjanCu00jUPW//dzCytIWqXIH2fYdh8tCOOHvsIOLypBjUvxeUcuDR7VsICk0so937d2sHZ4wiPR1Ec+NDtvR9LAUfXTu3oK8CjC1t0KxFXQqwvOHx+i3qtuqMGVPHQZOSnilL16F3+7q4ff0ivN4lYc3W3ejbvhEFJblIT0+nGRGI9/9SFV1Mmj4Vg/t0Rb36DTFuzGgMHtABUhV1NGzVGjZUOZbLVVC3QTPY2tihFtnihnWc4Vi5CmpUMkNYuoCNWzYiLzEE1x+4YsS3k1DVyug9dEDLwBojvx6CUH835KqaYwUF9DraumhF9rVTzwFYNnc0bl09i+hMGb6fNAE2TnWwdu1ihL1+Cd/wLKxYS7bE2gajJ49FWtwb+Aan4Nuxo2FhrPNhDKsqjUlHvsKzhzdRoGGHRQunY9io71DPQQ979+yFllMj9OncHjUbNESj+pVhZV8Z7Vo1R9ee/VDVVA27ftoJs5qt0aNtS7zzdcPdhx6g3FiEn5OejKbdBpC8NoOS/JUaFV16DhqBpjXs0LzTIKxdPAXh717h5t2HaNS5D6ZPGAZ+SeSqqN+yJWpXd+Sv4pZNCWI6Bf/iF3pTIzs6d/5KFCUE4Nz1J2jRrg9MqPrZoc9QGMrzcfzsNfQfNw9dGlSGilSGtMR4nKMCz6DvZ1PRpD9Gjv4awS9v4ty1J+jXuxusqbJbtXZTtGlci6ALqFGnCVpWt6FEKBdfDRyAB5QMBSQKGDl8NAV8emjdsgOUuXGQm1TGlHFfw/XBdXiEp2P6tCkw09ciGGX/330/F2pFqTh77SG69huJ6vaOpGNV0aBBbcjlMtRr1Ap1qztRQKaOdh27w9bcGFXqNCAbXgmtunZHJTtzqFDy0rhpS1iamWLo5PloYKuLSxevosuwkZg6rg+cHKuhlq0pgiMT0alnb1iZG8DIwpF4uRhvXO7ggds7dOrSH1rqWnCgedWrU1VErn6zdqhTtTLa0LjynETs2HsCnUfMQN+OLdGiWTOYaKmhfufBGNqzJa6cO4lcpTmmjBsJS8fKaEo2WUUhJxvbAx1aVMKZkyfhWLs1BndrhGpVq6BZvSo4sHMH8sjGTpw4GkNHj8PQjrVw5OBe5KsaoH+PzhAKcnHn+k2Ex6SL+IDCW4WWPgZ8NZRkVF+UGVMzJwzu1w26ZNt7du2MjPhwuLi6wfe1H7LzsqmfAFMLe1rZaQpV8ml0AEWU1GZlZ1ASVsJfIcgU6DpoKFrVMMGOrVuhY2yHTi1ro1TdCH1690DTFh3Qt10THNu/CxEZcvTp1QdK0uHW3XvD2kwXqpo6aNG6LXSVStQmvler7ozGjZqgmoMVpLQKWoN0w7mSNYbPXoh+7erg9IkT0DSuhKG9Oonj85uFQ3WsWDYZL2+fgU9gHPr37gJdlTzUa9gKNSvbQ6FliG59ekJPQwUGpuZo2roR9HT10KVTR9ja2qBZm1bkW9XIj6uhQaNmqFW/GTb8uAZJQe545B6CUeOnwNnWDI269ISxrgokKnro1qEF2SsBNevWJ3o3wf49O5GWr4Gv+naGqb4mutEquoWRLjS09dG8bUtYmJtg9HffIYiKwB5BMVi5ZiFMTCzQlPRdX08XCzf8gCpGUpw+fRHV67ZBi5oOcKpcBw1otVdQ6GPylHnQyHpH+vgIrTr1JjyM0LxDP9jplOL4qYvo8fV48kftMez7idCV52Hv/uOo3aw3OrdqjMhwfzx6+JAkgKlVtqkamGPboeNoV9sKD2ml0sM3FCOnLsHMsSOhpaGDVZt24PthneD+8hEev/BE6x6jcGz3OmgrVUQAlpVroXuPdpBLxK+ULOcjKSkdlF+WHfgvfH8/lfeY/5OPDgOGYvrk4UQA4UPLroPH4pu+XWFn74zlazfiyJEj2Ll9KzrQEqNMKiEmjUS3Lk1B8ZbYp2rjbhjcvx80dYwwZe4ytKhhIx7nN0GqwNCx03CQqp9rVi4lAV+BBtUroVe/wajm7AAbCka27dmHnTu20rJvM8ikUnQdOBL7Dh/G5o3rUMXGBJra5hg6chgZN33om9li/LhJZEB1UK9Ze+zctQd7qPLVq2MbqOsZY8riGahqb4XOXXqhQVVnqOtbYsmqzTiwdzdGD+lJBoAiAhExCWpTNW/H7rL+Iwb0gLqKKroP+g7bt2xGLWc7fD12Evbt248d29ahTjU7WNhXwerN27Bn9y4sW7IIE6niq6GuSfObhUWzp6CycyXMX74WB/bvw6Jp42FmoIMmLbvg24E9ICHyNu3YBYN6NoOcxulJCcru/Qewb8+PaEDODhIpbKs1wOr1P2LXT1vQuHYVqDM9FywnHPZg9cplFMxPh5mRARq27YuNq5Zg+MD+GN6vK5TqGpg0cy6mTJxAuExAu6Y10LB5J6q07MLB/XvRuwOPqUTzFm1hb2WGspcUHfv0x9iRfcu+8rtUBQNGT8f4oT3RvlMP4nc94ocAgXBr0LAZjdUNSlUFt/ynm6qGDoZ9NxH79u7D+nUrMXfOXNSrVRtjJs5AEwpCTS3tsGDZGhykgHjCiL7QUFOiS/9vsIcCil0/bUXjujUo8HPAuMmTYUYVUFMrB3w9dBgptQbsazbBD9t2krHahb5d2kBVqY6+3wxDw0bVMWTICLRtWJ2WNK0xe+EKHKBK6sxxQyjBKkt0QC/Hao0wrF93qCsE1KMEYNzX3aFQaqLPsG+p+rwPe3b+iOYNq9IqSwnMHGtgzeYt+JFksVENR2KTGsbNmE903YPly5dh9ao1sDfWRrOO/bBp9TK0adcNkylwsCCHM3fJGoz8qi8GDRmFxrQM3ozO7d6zB7t37UKfjq2gIDlo1LoPajuW84SQI3PcbcAodG/TBFL6amzlhKXrtuDw4YPYunULtm7fg4ljBqJa/XoYPmogNHhZm9qp6xpizLS56NexASrXaYqxo0dBT0tJZwDmX92GLdGZEr6ajTti1KjBUJMLaNSyEwb37AQ1Ch7GTZmD70cNhaGRBRav+RGHSF9nTxlDAYEaGrbpJV63rEJ9pEptTKSq7r5d2zCoRwco6Jga6cDEmQtxaD/RZOEyjB/cFWY2DuJ18gcO7MH8+fMwYdw41KxeFzMnjoU2qaAK0Xv4uClYt3QOWnfth25d26Blu54Y0qM18VMD302ZjYPEux/WLYK9pR4+fg0bMQ7N61QGBAEN2nTFgUOH8OOPm7BsxWqS9ZZwrt4Ag3t1hpoMaNqtJ0b2b4u3fl5IzytF4/q1IJXI4eRQGQo1DQwbMw2HDx3ED+tXoxZVwCBRQYe2bck2WeLjl76JJSZMm4f6ztbiYdEOTZqGOvbG4ndzx8pYsmY9Dh44IOr//BmTxUBNoLOaOgaYNGehiCeP1a1dMzoKONVpifkzJ4v0EA+8fxs4ahIGkXwamtpiIelIfSczyJW66EvyX6uSFRSqaujcvR9qVa+FTgOHU2GjESwdqmHZ2k3o064xzJ1rY9PWHThI/Bg+sBMkRKf3oGFsVRnrN2zA5i3bac7LYG+uCy1dawpav4GZoS7Zv5E4QrZ3y4a1aFzNkfoCjYjGO3bvx65tP6J9g6oQyB7UIXliGDtIDpYvnIVKZKfLx5ApVNCF/Mou0uUtG9fC3lQXBkS/6fOXY/+Bg1izbB6sTQ3QunsP9O7RCJVrN8Xgfn1gbu2IRSs24MC+fVgyazIsTPRQybkmenRsjHJfo2dZFcsWzyO8dcqHg0ONRpgybQpMDXTQfcA3OEz+6gjZlbnTJkBHvUwHpKpKdKdEqUub+ih7ydClW1+MH9G97Cu/CwLqtu6CfSR3W378AavIxg7r3QZ6BlZYtuYHkseDmD72GxY7qBFPv500FXvJho8d2gsqFOS17toXu3bvxvatG7FgwUK0bdoE7bsOwNe92kFC8K0dq+LH7Tvw3df9MXjU92RrDoBXdZcuX4jmlDi17NCVbMMO1K/ugDbU76fd+3Bg7060alCNxhQIQtl/pfrNyf7twtYfNmLR0iWYMLI3qtVrhl7d20JVIUPnnoPRpVUjqKrrYOR3k1GzkgOakz1v1LAhhn8/AU1q2UOdVij6DRiGKnaW0KDAcs7iVTh8+BBmThoDNSlgS/K8au1aDOw3AN98Px7VnSzAQXKn/l/j0MED+IHs4apVi9C2SU3Uad0TXTs3h0B/3fsNR9dWTWDnVA2r1m3CAeL3rHEjoK9vhK+o0FXZUhcqxIthoyeDH1m69Ye1cLY0hEOVuhhIflKppgIdQwvMJbnfS8HoQrIdc2fMgIO9PUZ+Pw17STa2bFqLGpWtoaqhh/HTF4r4rFu5BJVsLUl9NdG9U3s42pXpJQinPkPHkK1qBTnNC/RSI3857Lvv0aNLZ8xbvknk6wHS220kq1XsrKmFAAfnOhg+uD80lKr0HbBxqooJ48dDV0tT/M5vJtZOWLVpC/YSz5evWI7J48fAjJKqGdOnw8HGAt9Nm4O9+/djOcUKs0jPG9apRnOYSfwwgiYVPgcPHQEjbW1KPMaiTasG6N2zD5rXqwq5QhXte/ZGi4ZVIFNoYuK8JSJvVi2dDQtDLR5a3KRyNfQbMR4HD+zHxg1rsGThIpKdSujYtT/xpR6UetaYwnqkrw4rR2cMHdwL5lQtHz96HGpUr4mBXw+FmZ4WmB79+g8jnK1QrUEr7D5wCHt+2oa+HVtATkWimk26YOP6lfh6YF+MHTqAKApoG5hg/Ix52Ef8WLl0PsWQk1Gndl1MHDMOzjbG0DEyw9BRQ2FD+NZr0x0/7d6L3Tu3k1zWorlbYuiIYaJ+61A867XNJgAAEABJREFUt3zjFuLhPsycPBJaGmpo3aEnurVtTnZaQE1KvPaQLv+4+QcsWbYMX/dtBUNTSywkO3Hw4EHMmfgt1OUSWNhVwjK2vwcPk00dTUmSHOZ21dC+ZSvIRGr9/KZnYoNZi1biINm5I2T7v/u6D3Q0VcUGqhq6GDlhJg6QDTh8+ADmzRwHI11N8Ry/VaaC5LTpo6Am4W8gu1sXa1fMgrmxRtmB/8L391P5z2EuCMJ/DtivQBKEX47B33j7lea/OPwl7QTJr7eSfDL2x8AFqqR//J33BeHXYYnnP9OHj3+6CcLPcKwpwBrYq9sHA/VxW0H411gqCD/DVyPj2rptR3LU+h+D/sP3P0e/jwf9CEXx8D9rLzbiN+7IG+//xvYFTX7R++PxLWyrYNJ330D5OfL/XsAfjVLeVapQR6/+X8HOzOCjs7+9K1VRwtnOFgoy5L/d8t87+zEdPgtJqkDLTp3QvXWDz57+TxwUJD/L778DTypToFHTVmhapyry84swcOQEdCNnKHsPXxB+HkeQqqLngIGwMdP9d4b8bN9/StPP9vrXDgqCAEEQfrUzn+HtVxt8coJB8faLw/9w4BdnPzu+5D3Nf9nyl98kknKFE9CgVUe0bVGHgodftvln3/5d2fkt2ihUlejWvQ9qOdnh03a/h8f/hHyQ/EYDPsXbP6PDX33+t3D8rfn9Gt4/y8bPLQThZy4oOLH+agBMKUj+ucUfu/dbsvavzPHz2P48x384/9H8/+Hcv3jgS0EKwm/g9dHYgiBAEISPjnyyK5Tr/CfH33/9jZ7vW5R9fBhCkKJS9froRInHr0EWhF+HKgjCb+NbNtz/i/dfo8//i8n9f52Erp4h6teqARWF/A+Zokwuh5a2Fj5ncP+QAf8fANXWN0Grpo0+VBP+01MSKOjW09OGTCr8p0H/4fAEqQyVqlVFFUfLP3ysf3cAQRCoKmWFrj37YuiwYejcvjVVlJSfBStIZNDT1yM9+e/jyWcn9BsH31+w9hstft8pvm45JzMTJb+v22+21tbRhZqqym+2+bNPymg1oWq1mrAyNsC/KSW/ijpfg56XX4D/NI9+dcD/Jye4OKBUqqCg4PM3qf4/meZvTiMrKwvFxb/Z5H/gpCBeeaGp/veyHX9Hwkv+jkj9Kzj5v3qGtVt2Ir/oH11QYV42XJ49REh8xr8C+h/6JMeGYfee3QhN/BlefHgwbtx4gny+E/MfevxnDwiC8JsVJdAr6t1b3L7ripzsTBw/fhT+IVF0tOw/KyUOhw/sIfzLr90sO/6fek+MicCqZYtw4c6z906sBPeuXMDh4zd+McQbj6cYPuxrjBw1Ct9++x2mz14E/+BolH6h54sPf0NL2evg5+2Nw/sOIzU98xfwP/0S7vsEqzZuw5vAtzh57AQysnI+bfIvfX/n740Tx88hN6/wX+r/y06lCArwxcGT55GVk/fLU59+Ky3B89v34B8Q9umZf/t7gOdTrNmyG+k5WTiyYzOOXbiFvMIiFBUW4OGNi3jw2BX52YmYMXoURo4ciVHffosxY8djx/5jyOCbnj/BQBAEPLl+GsdOXUVR6Scn6Wt6fAwun7uBfNr/T/3nZ6Xh2o0biE9MwJXTx/DCM+iLQUulUsgpcZZIhA99gryJJrQknpqV9+HYn7FTWlyEu9fO4uSVB/ByuY+z1+6ioOh3evnCPBzbvQdXH7z6XSgHeL+Au68/wvzcsGXbAXzxqKX52LZiGdZvO0g2kQOyYtw/exiHTl4Xxw/wfomNW/aKCUNSdAhWL51P9uL5e3shNvmX39KT4/H4yWOk5ub9yzA+7pibnowjO3fDLygUT+5cxMU7T8Ez+rjNr+2fOLIXD156QxDK5KgwPw9XLpzA3ccvUVRc8mvdPhwvLSmBn8sjLFu5HmFxKeLx6NAAHDlwSPyxvOKCPDy6dRlXrl/DvInfYwTp4rejR2PqzLl45OaH4pLPKJsI5cve8vNy8fTZY8TEJ362Q1ZGPPmSvQiNTvjs+cDXr+Dq5fvFNv2zQOigl8tD7Dh8/ovpTl0+/CfFhOHAgf1IzMj8cIx34oK8sWLVFiRnF/LXf38rycOpPT/hqavfF8G6deYgzly+/2/JfCHx/9aFc7j/1BefCX2QlZyAB3efIP2jh1p8jNzzGxdw8sJNFH6BLH7cr2L/36XAf2f/350wZGekwsvDA36+fuAfKiuk9JSfYOLl+Qqurm6ISUimoCIfMdFRePf2DVzd3BAeEY23/q/h/soLmbkFyMvNQXhYGF77eMPD0wfR0bHg/v4BwSgm+1ZUkI/Qd4FwdXWFj58/cvIKfkHdUnKgMeGhYNhvAwIRl5CAqPB3uHn/CfjJDlERUeCKS2FeDiIiwhAZ+hZbt2zGvRfeKMgvRDT1dXdzhZePH3KoupCTk4mw0FD4ennC0/s14R6DV688EBAcDr6LPyIiApnvg8uk+BiEBgfh8eNHSMrMFfEqLirA/SvnsGH9T4iMS0RcdCTB8oLvm2AU0lyC3ryGC83l7bswlJADSE9LRkjIOzAO3q8DkEc4FObnIMDfF65Ew7DIGBq3gGgUjKDAN/Dw8ERcUgoZ3VKibQEYnpubB9Gaj5UgJSme2r2FG9E6KDSCxszDjTMn8OOW/UhMTYeGujrkUgnysjPg7emBVx5uuP/gHlKzc4geuXj72o/GdSV+RojGKycrA37EGzd3GiMxVTyWm5UOb69XNIYHkvipKuTqY8ODEBYdL54XCUFvpSVF8Hv1EteuXsXuXfuQksW8K0UAyceL577U4uf/qLc+8PEIR+cefdC7ZxckBblg4erNSE5OQijJR37Rz265lILj+MhwGt+NeOSDtMwsZKbE4/qNm8SvCLg8fY683Hwkx0YRbSNF/kcGv4Obq4v49JzM7FykRAfj2p37KCiVQ0NDEwW52cT3EEo4fPDK0wsZ2RxglCKT+ONN+Lq/8n5/7GecszPT8C4oEJ6vXsHHP1A0tEmxEXj+8BHphTvciVdpGdlih3QKXDyIJ14+r1GenCTERRHf3eD3JgD5xPcc4klIcCDJvwfJ+hsUkAIkJsTi0bMn8PH2hJv7KySnZRK8UqSQ7Hm4u4l6lEg8yE6KxKbly3H97lPk0NwjQ4LAOsE6w8lGaUkxQilxdCOZekdywQEKV3bDSX5dXVwRGhlLcIHMjDQE8/mPgtC4qGDcvPcY+ZQguD++g1WrVsH9dTBKigsR5PsKAYFhyMtMwrM7LqjbpBOGDP4KrZrVxM51y/DIxQuJCXEEM0qEX/6moqoGdaUSWTReaOg7eL1yJ16+psQoF55P7mH58nV4FxFDFb88vAt4g5cvXRDB8kW8TyHHF/DaF6+I7uGRxGPirQfx1vf1W1F/GK8wshmsA76v/QlmHnzdHmLJipXwDYiAqlJdXJErJtsRGhwAl/fzL6XsND0thWQmSNQLb783yCEbUULtot7T05tsEMtPXMQ7sPzkfJQYphNeQYGBeEV88Q94B/a7Yt/wELi6uFByGkw8LUF2ZjoC3gXBi/TvXUgY6XYIfEifPL19ERsTRfLkjoCgMFGXCihIC6b5u/L83gQir7AQ/r6eeP7KFxpKDShVFEiIjYSPjw98fX1p8yM9zwTboQA/H1FmYuOTUUJz4xswA8n2viK5vH/jDrwDIsvZQZ/FCCM75OvljcCQCMIxDV5EX9b76LgEFBXk4ODOH3D47FVkF5RAU1MDAsFMT0midu5ku30pOcwnOJ/5F4rhcu8a1q1Yikt3X1IwU4q3r57jhctrlBYXkH30QLZcC1KSUW+yF1euXMGeXRQE55TBy0hNxNvAd0RPcgjvwWdnpuEdya4v2SZP0qkc8gvMP7Z/nmTTPH38kUu8e+vjgo0/bsXrwIj3PfmD9If0yp308ZWnJ9ErXcQjPDwM/mT/Xr3yRFJqJkoIn7iYaLwlm+1KNjsyNgmFZCdeki6ERCZSJVId4r1ZJYUIfxcAbhMcHiXagZz0VPiQ3WD6RcTEE6wSuLg9xZMXL8mGuyMiNoF4VAhvknt/0RcUk5z7Ewx3RNE55ldOWiLZvnAqfL1PzUj2E0iWjhAfNm4/SP6qGGmJsXB9+gzZpPM55Etf0Zj5JF+Pbj5DbdLFvr17QFuWjelTZ8DrXQzSUlMQFh6JYhZOJgVtzMOwsDB4ET3YXrD9oMNI/mCfAlFABYKo0Df4YdNGuHq+IV6UcBPaSpFGPsfD3Z1k0BuPKaFITktHERXm/MhmuTMtyT4VkE87sHMTjpy+LNq/tMQ4uBNNfUjH2D6VkN8MCyHbRwWfd8HBCAkNJj/2BmyLY4gHvl4eeOXlR/MsgFyhAk11JQop4Qqndr5eXmRrX1EgnEf4AOkpiXjl4U4y6YP0jLJCUFZaEjwJx1furnjw6AGycnPFtvxWnJ+FvTt2QKFnDUMtFSTGxcBdjAn8kUkyyLiHkJ3ncd6FRdHcy+Qwk2AGBQaRvnqQfIYhjnTXncYQ+QcJyYcGVFTkyKB2XsQXd49XSExJI99dgujIMNEmvH4biGySXTWlEhpqatQ2FSFka16RDHv5vkEO2xfiexTZSBey3W/fBlCMk0TyVIYD48+xzRtfH3gQrZ89eILA4BjibxFCRbvhRkWkdygk/+n58AY2b9qGd5FxyGW/TjGOq5s7wiJjaU4lsK/kDJf7txAQHM1gK7YKCvwmBX5XwlBakIudm9fhx+17sX3jOoybswoJFBgc3LEFh46cwpkju7Fy7WYK0sOxd+s6rFizDYcP7sH0abOwa+9erF82D0fO3kVUsB9VoBdg36Gj2Lx+FWbNXYiDh/Zjwdw5cPWPoiraA2zYuBW3b93EptVLceXeC3I45fMoRWigL9atW4fTZ89j5YLZ2HHkPAWBCjEITI4Ixv4d+xEZm4zkmFDs2PEj/IOCyAiHwYcM09tXL7B+zXpcunQFG1cuwsmrjxD+xgPLF8+nORzHupVLMXfBUhwivBfMWwDf4DhcOHEQT9x8SWGLcJDgPXsVAIWqEtL31UdW3hBS7tCoQLwOeI1D+7Zj/qLlOHvzIe5dP4N1G3/EtcsXMGfBIni8CYHrszuYOWcBTpw6jeVLF4tPbnp86yLWb92NmzeuEn234x2tWKxYuhCLVqzHkSMHsWHLLqooZeLhxdNkwLfhHCUES1dvQER8Cu5cP4u5C5fh/IXzWLp0KR6/fIVQ6h8S8YYCgVCEhoUiNS0DR3dsxPoff8LJ0+fw9l0ElHIBN0/uw6bNO3D1whnMmT0fgRGxuHn1DPYQby6eOoT1m7YjmpKg0wf2Yd+Bk7hw/jS2USIQk5iCJzfO4MpD119UHfPJKLtTcNKxx0Co5kTh6sNX4JecqrWfXkIlEP1MjMxQv34jNG7SDLWrOyI+Pg6x4W9x8dJlpOSUOQPQK+ytFxYuXowr129h7+7tOHnpNo0rh5qqGqRSGdQoIEyKDcMKosPDZ77wcX+KhUuW4cbN29i+bQsu3X4EvjnRfxgAABAASURBVIFcVVUFeTlpiCQHGhXyBrO/H4stO/ZiIwXE/ASsnOwsHN6zA4eOn8TxvTuwecsBZOQWofz1zucl5k2fgUOHj2PNkoU4dfUhIEgR6O+BMySPP5FeHDl5EfGxoVi9bAH2HD6J3du3Yt/hM0hNjsGqFYtx+txlbP9xEx66BSCY5jV3zmwcIHqvXrEEJy7dhUQiQSQdP3P2HHZu/QEHT1xEVGQIVi5fjBNnr4hP+th98CQFe2EIjA5FMDndx49uY/HSVbh1+y52UJ8btALg6/aIgvDl4mN7N23ZisCoBLz1eEw83YRLF85i1dLlcH0dgVDqf/biTXLM+Sh/SYmmqioq9FWAtpENbPRVsG7DFqRRE1U1VcjoPJVNoaGlBTNzS9ja2KGSrR2UFCgWFBbDw+Upzl+6Q/1//k+MeoewsBi4vXgE1q1jJ05hLc35/LUHCI6IQHTsOwoWfPHoxjXi2W5cu3IZK4kvPgFhuH7pJKbPmAO+yfTMyaNi/5PUf9m8+bj3xB1ez+5iyZLVuH3nDnZs3oTr958iMOgNIsLD8ebNW4QGvUVqeh58nt7EypVrcfLkccyZNw9ub8Lx4vEtzJ2/kPTxFNmBBbhJMu3n8QSLlq7ETaLnzm0/4NqDl5DIVMDyIwg/z8n19knS5UVk5w5jwew5eOIZjNferli7di3OnzuHNUsXUZLxDIGejzBt6jRs2bqT5OQsFi5YgMNHj2LDioWYP28ZDuzbj1lz5iEgJh0vHl7Hph+349at21hFPH/g4keyqybKelx8FEIiIxHg54GrlJQfP3wAM2fMhQcFGtdPHMKa9dtx/uwpbNq2U3w2veu9K1i5ej2O0FjPvf2gqWSeluOfizUkj3MXrcCla9fw06bV2LH3GM6fPCLeKBsZFUaJbRAlyBTMkQ19Q7YrJz2J6LsBe/cfxq4t67B62z5ahSooB/jzJxVG9I3N0aBRY5w5cgBBYQlQIV1VKORUuEhHcFg02rRshtycLErePNG1zzDIUt9SUaesOhvi74n9x05R4FyK8ldYoDvGjpuInfsOYvWaNTh5/SmyUuKwed0aHDh8DFs2rMTmAycQQvbuHSWUPn7BoPxG7J4SE4wVixbh1LmrOHZwL3YdOo3s9HhsWzMPq9duxqE927Fy4w6kpKbj7MEtWLHmR5w/fQxLl61AaGw61CiwU1HIEBUVisiYeHg9vyvq25nz57F29To8e+mKn7asxbbdh3Hm1DGRfwkZ2VCllZbHt6/g6NFDmDdvKcKTc8tgySR4ceMCVqzYiHPnzlL7rQiLTUJskCcuXL2BtOyfaSrIlOLjkH0enMPRSw8gkUqgIN2USgVkp8YgNU8GOzsr6OgYonnL9ujcpTtmzJ4HJ718XLjrgjevfXD1+l3k5v8M0/XBFUydMhVHj58iH7sG9566IyEqEIsXzMKBIyewcfUqnLp8n+YbTkF8EALfhaKosFikZRolXru2bMSho8dx8vBhKlylU0FKwMn927GJYoMzJ47jp58OIDo+nnTPn/oHI+C1NzauXYlj5y7hwO5dOH3+FrJpBXDF7DFYvGwtbt64SnI8A+t+2I6ftv6A2bRCcoRs7KqVy3Ht/nMqIsUjKDwaSfHRWD5nKn7atR8bly3Fjn0nkZIQjX07t+H42Ys4fWQf+alTFJfEY/u65di65wDOXriIqLgkSCQ/hzsRtLrw4l08BvTvhPiwAKxfvRYnT5/BTpLpfScvIppsFevryrUbSSY9UfQ+2fJ/dhWziLb79u/HzGkzsIRsyb7dO0hf9lCiko3I4LeUGETh5KG9OHHhKs6dPERyfBoBb72xbPkyXL11B3t2bMVTdx/ERwQhMioBz8h2zyP7c/zkKaxcsgA3HrogiGzIosVLcfrMOfHY3tPXwI98ZgaUFObj7uXTWL5uMy7S3B67eUGmpsCrx5cxn2zWtetXsX7tajzzCkQQFVGCI0l/w0Kw76dN+GH7PtE+rNv4A6JSMmBmVwmmunK4eb6mOZYy+IqtggK/SoGfNehXm/x8IszrCS7edcWoqTMwbEAPJJDRT83Ig6l9JfSgCnHdWtVFQxpNWXciVai6DP4WEyeOpIArBx17DkHPVvXx9P5VsVKanSvBmHHj0bdTXWQUqmDspHkwlmbiBVXVJFI1tOvcAW3btIWmJJ+qBC8QGxkGP6qmvaXK7IO791CiaYmpU6ehb/umiA6LRWFxKQQKQAvJAYUHhyGXMvgCWmEIpmqEoYklateqjW7du5ChlaN+ixbo0rULVWEK8fTxXarYxKFQ0MTY7yeiXWMHZAtamEIGSy03Cj5UDTDUUqNKkSdiAj3x4IkrHBxsIJP+TDoVdS1UqVwDtas0QpOalRFNqyzt+w7F5JEDIRFk6NS9F9q3aoI4qua5+IYgg1ZpDKyqY+r0WWjiaAoPt1fwpcpLJDmMug2bokPLppCVFiEwNBItu32NyWOHIz3SDy/JMBymIFbNxBYd2zbH20fncPbGE8SnpMG+RjNMmToT9W2UZPxfopJzDTSo2QI1KtkjPCIc796+wsmbT4h3czF6+FBYmehRwA3INXTQuXsPtGveELEBL+EbFAIvLy8k55SiTZdeaNagNqKD/HHuwg3UrN8ALZo3gwcFXS6v3qDzV+PxdY824hN68P6VnhoHFw8/1G3YGLXtDHH22CHkFAl0ljf6+OhfoVCFp+d9TJowBqNGjcD+S8/xzdChcKpeDyOGfwNDDeWH1kXE31qNW6F/787izdhur95Sta0IILBSmZR4GI4p48ciS8sGvXq3FB1YS8K/a+c20FaRwtM7gNoK3Bz5uRnkEKJoJSER8ZRwfTNmMvp1aoJnzx8hLjaEkotncK5RD+1a1sbpk3vh4h2K8lcmVQDlSh18+/0UDOnagJKLg0jMLICZjSMmTJ6EcUO74q2fKyVxl/EyLIeSlgX45qtecH96jypgr3D34RPoWjqiQ6fuMNZWRXpqEkoVehg5dhKG92mDwwf2ICohDUamDhg/fgImjR6A1x7e5JQzYFe1PgYN6EWBuQXcPX2hQW0aOFZD/XpNoK+liaYdOqNLh5bQVZfjFQVLgV5ucHPzh3P1uiQvLaCuKiN8dyBTooH2XbogNcYfO3YdRaUqNTBm5CBovn+KUvlcxc9SQKbQxrARY1Ec/hI/7jmJEkEKQRAgk8rJgYdg09qFGDqoD/oMHIlOI6ejVaNaaNGmE8lZXxFE+VtyXASiomLJmSdBVc+K6DWV9Lcu3N1fU8BTGZWdGqBDg+q4cuoUVLQN0b5zF2REeeMkJViBtNpnVbMlFi+YC31FIYwtnDFl1hw0r2aEVz7uKFYo0bprD3Rq0wK6igJKiN+hZp3GqFK1Kpo3rY80Cioy05NxZP9e2FVrgUWLFsNRDxR8HkdUbAIMzStj8pSZaF/PHs+feyK7WIGm7TqhW6dWMNBUgZv3OypalELAL19JMeEwtnTGDCoy2OoJeO7yBPduXYeedVVMmzkb/ds3wOVTJynoDkBukQaWUSBWu6otcqFB9mYy2teyQomqNqbOmwNFXjIeu72DXE0TbTt1JvvXCorCNDx3fwOO1SRSKZKoShtDqwd1m7TH95TsSnJSoW/lDHstAT/9tANGTrXQskk9BLnfx40HL3Cagu4aLTph/uzJsDYzJDglH02gEGGR0ejY52sM6dkROibWGDZsIGpWdUaQH9FUoobWzRugfv36MNWWISw8Fm8oYfamQGvkuCmYN3MsXlw+ArfXYR/BfL9LkXoBxae9h4yFjXYJTp06g2I6JggSJFNRILVAgep2RshKjYaHzzvUatgMVR0tcXjvQeSRrlep2xyzJ4+HmlzyHiCQkRyLuEwJxk+ejbZ1q+LJSx8E0DzfxeVi7IQZmDV+CK4f34cihT7q1WuEDqS/JKYAQCtwRXCqXReDB/eDg7U5Xnu6IC8rjVafo9Cq20DMmDQG3vdu4JmHP9KoWt6sXTfMmrcEiuQw3KEEUpBIISX/kkAJW0RkBC5Qgm1duwNmT5+Krq0aIj8nh+hni/6D+qNeDWdaLX6LiIQ8SEhHWrTthoUL50M1JwJnqEDFxZMcWp3bvv4HqBlbo0ObZoh664YTF+/DqkZzjBw2mGROVcSb34qKSuFItnzO2EHYvmYRAmNSICObJydhfEcrT1oGhjDS10QJ0be4qJC7QEPHCJa21ggPiUKNug0xjOatpGKJeJLekuNiAJkRJTGz0K4R4RvgQ3J6EAEZGpi/cCHZw8Y4vG8/NIyd0ahRQzQkP6BQyKhnKYICvOAblYaJkyZj9KivoauUIjEqEJv3nEGluk3RhHT4ycObeBtVjBZNG6Nps8aIfeeNS08D0K5DJ1RyNCZ/chEhJE+xEYkY/M14dG3TgIoG8ehOPqVnp3Yiv76bMAlt6zjCi1YZ0mnFKYRW3nNzspFXIMGQEWMwemA7PHl0E54+nrj51AeNmjQlXa+Fu3cu4dK507jhGohp8xdj2KABMNRS4kP2SLMIehsApdIItsbqZJvvIrVEHZOmTMf3o4fA7f4VWj0OQkhiFsbMWIrBPdpBQfSmbkhPjIa2gRWmzp4FKVKgMK6FMSOGISMmCCnJcYiPDENsVDRcnrugUKpE567dULdGZcSEB+LOMx+YO1ZGpy5dYaavg/joMMTEJiI+IRF6Zk6YQnFVp4ZOePHUjeTrKmRm1TF/9nS0b1IHCdHJtIJQwiggNSkOl67eQ4f+I8h3jkNtsifFxcWk21K06dITXdq3QAnZhWd+MWhYvxHqV2+AGk520NQ3Q99BA9GwTlWEBgbiXVQW5CoqsLAyQmREEK0mF4rwK94qKPBrFJD82onPHQ8jQ1+oZorKthaoXNkBNpZG4CXhGKpQ7tm7D7cePUfxewOvVDNA9arm0NHRhrmVJSytrWBsZQGFUqBMFjA2soKBvj5VKHVg52QLMwtTmFibELwCFBfm4QpVyQ4cO4FgcuaCtARXTu7CmO9GYdr0FQiMjoextTP0qX/lenVhpE6GrLQcYwECVRIEAQSrGKW0nC+VyiAlZ6uiokaBZAke3r6O3fsOIJCCF6lCSg0lMDMlfAz0CR8tOFSygamxEYzNjVBQlAenWvURHeiFE1SV1HJqiCp25iilpesPIwoSSGUyyGgcVYWCYGjC3t4SulpKFJcU4uzJwzh04hwSkrMghQCFQg6Hyk4wMDCAuZ4R9VVB50FD4GQkw9rlS3Hmwi0kxqdCT08PjZo1gJWVFUzNTcX7EOISMxAe/Fq8XMTCoRJ0dTQglSsoOHIkeHqoVac2UnPzUCRIIZcpoELnmBYpsRGQqKqhalU7WFlb0nyNAZpDdmYWThw/hCPnryA5KxuCXBXduvWEPDUM8+Yvwb2nzxCfGI90Ouf69AHu3n8AIwtbaGtrQF1TG1qa6jQjfHh5P7oBL/+32PPTFrzwD6FK/xO88AqhNhIIRKcPDWmnuLgI5sTHAQOHYPSY73H0xCl6iesOAAAQAElEQVSMHtgRKgpVaFPlWkZ8pGbiv1RSAn/3B1i1fhPcKCEpKaLD73kuEUqRlp2IIFpVkgmATCIHy8DTW+fx40/7yPgHE7/oBHUp+xfAf8VFxSSXdrAwt4CxmTFkChnSEyKRmpFCVfCnuO/yFrVq14G6vMxQl/UthVOlqjAzM4NzzTpQ5seDf3zH2tqe5NkAhmYm5MwFJMdGkVw7kWPQJXpbQUeRD6mWEWZ9PxKPLhzEDgru3oRFiHjaV6sESxq/UpXqKJWClquLYGJnC32SRx0DI2gQLyWCQE7XE2vXraVAyRUFBcWQSkjmiEYKhQJySSGe3bqAH7fvoqpwCPKzC1GvQ19079QYu7dvxv6DFxEVTs6Jgq5oWg27fuUaFNqmcDTXAz+aT5sSDolEKJviJ+8chOgaW2EFrZjcOLYN1594QSKVkgMrgp6hDSZNW4DF86aLTtncxhZaVMVWqmtAW1vzl5BoDvQPqYoqLB3sRf01MDCBWqkAqSCBVKqAQi5HQkoq3nJV9PJlqBuQ7JsZQq6hAccqlaCnowOlmpISDOqvpw9TSzOAA6X8fDyglbFNuw/AL5gCWBpIKpNDSjRi+kglUgiFWUjIKoG1UxXo6uqies1qiE1IAIh+1o5Eb309CryMoUpyJSktxPN7l7Fpy0/w8Q8GSgRRZvAPLwVsSX7MKQE3MTOAIBRT8JgFaxsL0l9d1K5dBQohE2k8rpUDLIz0CX9VmDvweAYiHrZW1rA0N4GFuiaKqdBRlJeBS2eP4MiJE4iMToJMkH4YlaYFiVQGCc3n3N51eOKbgLmzZ0CGIiSl5CE6zBv3Hr2AgZkFoVyMwIQc2LFsGpuR3DqS7S3+AAtENzUNdThRgqBL+pxBleNNG9fj+oPHyCR6SiUSkiu5yBOZXAo5BU1xyenQ0DWHtZUprCvVgYGhLqIo6WY/gE9ebCPlanr4auhguD+4iideQQRLipjoOGhrGUNdTQ3Pb12C79vX2LP9B/Dqq5/rPbx6HQEF2So9XR2i589AiwqLYO1gAysbI5gQ7+XE29ikdOiQL7G2MkGleg2gVFdFfHIm5HI5rWiofOgsl0sQQlXuFZSwPXb1QL5QQueKIde0RBVnB7JD1rA3UiIuKQmqmqZwtLGEnp4uale2REZ6ClGXmtO/BAKKiDb5hQWo17QeDEg/O3Tvifo1nJCTHEHV8Y1URb6PzKw8cEVGqaMDJ5ZbPWNUqmqP5LQkgiCgMDcTsanZiKPq7+27D6CibQQdPXXIyUexLkolAo1W/l8qJgNNe49GpzoW2EJV/JScYoJTipcePmS7bKFCzUupuYR4Rh8oyE1FIhXuTEiulERnLS0NkhlqxCdpk8hkqFS5KvT0dak4YQSUFiMhIoRwrAxT4qlz1SpQ5EcjMzu7jJakI4JA/dlnJEdDh2yTgaEBzGzsYWxsgLTEGCoM5SHA9xUeP/eAiYUlNAgpiZT4oJAiKyOBAtIc3L91jVbhI2Fva4VS8q1GJubkK+2JVwroGxuicvXKRFMdVHJyhCH5R2t9Y0hKJeKlehIav5RmbW5uBTMzM+KZBWQyCdIpUM/KTsX9u3fw4JkPbO3skZMYBg3q72hhRPbXkmDqiTBo6uJ/Dq02SiiBl5IOJKTlwczShsbTh5ltVaiqqyM2MY2OmRM97MRCCg0t9gPksLSwgoWFATS1tcjv1oS+kRG0OGGjoB2En5q2AQZR0hdGyeyChStw/54rzO3qYMLgrjizcwt+2L4HAWFRxA8JtQZkaqqwcrAT7aGhgTEVCfIQT37ZlvRLj+ZgW6kK9DTkKH/l5GQivVgOB2sH8hEGpA82RKNSSIVC3LtykooghxEaGQeBnImcbAVvKqoKFGXFi6sMF6/dQhpftsU2jSYmVaghh2S6hFYFP6fH5eP+fT4rMPmrKCD5PQM7O1aBQX4iLl+5jks37uJdVDLiIt7gzoNH6NK9Lzo0q438jEwUUjmskCodRVQZIVMHvo6WLBKKi4poWbMILJgFFMiTrorHiskI8fki/sXB0hLcoaVaha4FRgwdBDNdJQVkhegxdDyOUAKxbetyNHR2RNirx3j58jkuXLiAuOwi8n0lyM8vgIa2GkqQCV9ajXhy/zbCo1IhV8gJpwKEhQXi8tnDSM6V4GtSaGtDbXIG2RTUl1AAVkgwQLgWEX7FhE4pCgkfvu7TiYyXrjQZ+889QreefSAVSmmsfGpf+oF8ChUpOexIhJEzZMdWSsajlBz/IQrgDG1rYVD/3tBWF8C/aFhE5xg2K2cROZ68vDz4vX4Lx7rtsHz5ImREh8DTNxhZmWm4ceUKnj17gfDQeNSr6ghbKxs4OFVD966dyFCZwdxYDyUFubRS4kJz9sHNaw9gaWgEDTUBMfGhiKHqBY9nYO4AlaJ8XLl4D26u7ggKiUBxdgKOH9kLq8qNMKhnJzLwCmSlpSEiIgytew7Eoqkj8ezudcSTcbUyN0dDWu7u3b0zzIyNoaWhRPBrT1qRCCN6Q3wVktE+dPIiho2ZiU0b1uGnvUfRtZ41bl69jNz8PISFBNBcnuHZ06cIotWTPDpmrGeFruRwu3TuhBqVHUU46VRB8XjlhWyiv3iARrh/6zZe+qZi8sRJqF7dEbmUVJYwHUmOCqidqVk1HDu8F3E+13Hg6FlcPH4S8QVaGD/mOzjbmxFfc0U+F1L7EjKMRZSs8Gc+0b6kpJjOF4H3dQwsYElOrHnrDujUoiF0KejVIadahgcgCBL4errRqpArrl6koNvUGdoaqsilJK0UpShhGS8phYVDZYT5euGxhxdVrF2QmqcBWX4GguOyMXnuQtS0M8CV24/AiU2AtxclQa+ITlehq64PHS11ERfWD55jCUUevm7PcfaaF0aNnYJG9euisIjKtwKgoixFeEQwTh4/j4RcXUwcPwZ2NqYoKM5FyBtvCBQQLZw7EyUpUXDzeUMJY03Y2FRCz5494GBpAkNLc6QkJcDL1x8FFJDh/YvHFXWU5lREc2Ja1W7VA2MHdsJDCijTc0tIR4ohQAYrclwdeg2hwHU8Ni6YS5U0L4TQUriHp/97aGUfnCAWUZLGn4XkoEiBSP8LUUDHVJRyZJNDCyJHZ0HBRrVa9TCgXy+YGxnCkBLnUuY18ZkhsT1hnpcybsTPwvxs3Lp+HqkSE0weMxKOlsbIz8uHVKGCvOx0hIWFk/zlo1imBScK6r1ePICXlzse0mpPFbIlUoKTT7ajTB8LSe9zce3iJUSnq2PyhPFwoAJBLumYiDeNxziUb2zT8snWsSUooJJ6EVXHjQyN4fnKmxI3f1y68gASVTNoqclFnLgf07Iwv5B2S0W5KyY7CcKBZbO0JA+XL1yHpkFlDPnqK2jrKCmBzClrRzTgvgU03zNHdmL9/ksYNm40SnITUQAprMxMYGNfHT26d4GpmQUq2Vmito0+Xj55BL7W3tOX5EEgoaGRy/8LCedi0oWQN6+w7+gp9Bw4Al3bNIWEjjFaMqpKR9IKZUpqBsl4PmwtrZGVEEK21xVPbp5Dcno+HCz0SCdeIZyqpeVw+ZPteUFBPqrXbYwe7Rvj+qNnog6GR4fDlBJiSWEGTp6/jW8mzBWfDb/70BG0rWGGK5cvIYbGfPrCDYWkSwyLN54785XUV6RHLumuja0NkiLe4IWLG26dO42CYhmc7M2RnpaMYLIxrEPc1/3ZHdx47InvJ0xBs3rVUZybT1ZFgsL0KJLnJ3h8/zGC00spUbBADumKi6ureK/BQ88wmFtaiIWnEvJNTCtBrkJ2QQt3Ken2e+2Lndt+wL5Dh7H1p/Po0Hs4OndoDYmUeEvFosyUZDx/8hyvSH89XPzgRAl1Idl8qYISNRtzmFtXQvce3cXn2luaGiMzMQrepIs5BUWMtriJuvhePidMnwdpZgz8w1OQGheFoIgkVHJ2FttlZiXDzeWFeH/d3u0/4U1UPq0UNKRKdgS8fPxR+Av9LkKBqIMgn1yAEokMjjXq4o3bC1pl8aQq/UNItZ1hYqCHnOxMRFLVvJgvy6FEVdfUFqnR0eB7vF69eIqwyERoG5lT8UsXVWo2RNdOHUgWjWFgpA22b1GRUVBoGMBQSxdtO3dHy0b1YGJqBHXyIez7ikmuQXxmHSwm/eH5FheWkEYAxcWFKKLzJbQVkp0oJR6wTLEssO7xvq6hKUyp8NC+czd0at0MRoSzY61GyKUE+MaDlyT7bmQjY0Qalb/p6GshvzSNNtIbonuIvye8ffzg8vgaCqgYY2GsLeoruYbyLuIn48p2kvEoJN0pJSkqJYEsJLtQSsJWRLYyIyMdwZEJGPH9VEyjVS/PF0+oAPUCKUVyLFyxEjVtdPH0xUvShSIUFZWgmOYlwuL+BKdYkKMy2UC/h1do1fs57t6/i8SsQhpfoA3Q1NKBmRJ4SAmSr48PrbD6orA4BwcokcyTW2Pk10NgZKiD7NwcyJUyZOYkw+uVCzZtPoamHb9Cjy4dIFOQ7JMPYTrmZ2dBR10LCZS8urh5k7cRh6l4q6DAP1DgdyUMRraV8NWAjvB4dg8v3H3IABXC1NIBTRrWJ4V4DP/QZKraNYFcRR2OlStDnbJahUKDKjiVxH09IwtUrewMHX1DOFVygFwuAx9zsrOGTCLAjiq31uT0GjVrA3lxFq7euAUNQ0eYmlhBW88YdlQ5sLOzQYOmzWBvpobz584iMCwOLOHa+kaoxZUcMxs0algT929chMvrKDRu2Qq6VKWoUbUy3B8/hH215rDUV8Pt23ehNLCj4NAaSl1DODraQSaTwsTMFvbWFmTopHCkiq+5kQE0dU1Q2akyLRvaon2zGlBVaoIvddBSU3wgqCNVZMxNpHjk6gt7x0rQ19WGoFBHr/59kZMQiodPXVGjhjN0NAToUlBqY2EMKc3Z2NoWTvbWsCYD6u/xDFdv3oMjGbtmjWtASmV0t6d3cObKbdRu3h4N6lTHmKkTkZcYipOnz0Oibo6qFMxwu0Bfdxw8sA952jbo270rqtaoRpWRHLj5BqKSkzOcKtfEpNGD8fzacVy5+wjGlvbQpXn17NEbaVFv8MjtNarUbgwVqRp0dPTh/vIJ7j/zQLcBQ9GJHED//l3h+vgOLSVfgVLbDBamhnh66yTOXL7J5BfpkEaBgJaxI3r27Ea8soMN8Wv4yG8hLc2FjokJhTRJOHDgAA4cPITHZJh0jC1RrZYzQAZXBCC+lSKVln2fvXhBgVK+eAQQUL9xM9Ry0MdlvrchsxiOVnpQamqgXt06xF8DOFVyRtXq9TF9yngyfGGoXq8JDFWLcPnyFUCmSg5MBwqq4tWtVZ2q1LrEIwfigzGq1qoJVYUMOuRwqnKl0coJA3q2pWXq2zh79R7snKvDwlgXH16CFEkxkTh74ij8YnJpWX48VZxMYetoDznJj6qWPslSJdRv3gl9W9fCod278OAF0bFfX1SvQWMJBbhy/gLyFHoYNqAHVYFovrSqcf70cbiFphK8vbz0HQAAEABJREFUCbCjFTlHCqgYnpq6NhwrOaJG3QZo17Qq7t+8gsi4FDjbm5KeydCsUwvERofBoXpdGCsLcenSVQqMNUietGBtbY1skr0rN+/CoVZdtG1ZD/2Gfgc91XycPHkKyXkC6tevjQhK5I4cv4SMrNwP09QxMEWdGlWgIpOTXjpCX08LoLn3HT4OI4b0I53Uh5Tku2bDOtBQlwPEo679R2B475bw8/KGn68POUUvfPwytXEi2tjCxNgU9lTBlUol0DUyg4OjFax4jlUNcO+5J3oOGYKCtCgcP3GSVstUUY1siYOdA6zNjMABiLGFNSxpZUHC+kOrXfa29mjZvC305Fm4TEFcsZoxdIkPuobmaFDNCZ4eHjCwsoOenj4GjR4HZEVj9649EIwrY/ywPrCgFQJbS1NIJRIYmVsTPrZo1aYNzLVKiZ5XUCCowdZUAzoGRqhbuwZUqNqO9y9jGwfYkr3gr7ZUULE2M0WbTl2hK8nBgb174ROVhkFfD4aNrQOqiAmxAB1dA1RysIVMKoWhlT2ds6DuEgrYalDl1IjGbgVSctwgvpnYVIKNqTosaJXRkQJMI1NLWJM8hoREwYGS0tduT3DkyHGEp5Vi5pypSHzniTPnL6NIqkN2zAZfjxuD/NQwHDxyDiY29rCnZIoGe/8vR82atWGgTfBtKqNf9w54xcnUm3BYWlUmvVaget2mKEyLo5WZIlStYg+HKjXRsVV93Lh4Gocv3ke/kRNQxUIHrmQvuKr5HjAgSFGJdMvMWBtyVQ30+3oUBvboCRsrU4D4XrOKLdIpONY2d0IvSnDs7exgQ/iNHD0CCqEIwe/e0krJYxRSQIX3Lx0DM9SmCrRMAhiamVNCZAb7Go3QqkFVXDx1FGfveuCbcZNRv2Z12JF9ekYJRxEFoty9KrdrWBW3qHgRFpMBCwtHCkgFUGEdLx/cxsnLd9FryHDUdLKmFaI8uFKStY/451C/Lbq0aQwn8lu62trk7+zg5GCHAQP6Q5b5Dnv2HUB8jgyt23XG4H4d4ev6GF6vQ8jmWlMtOhfOlasjMyEM+/YdhGPDDujZthHMKelycq6GaQtmoTQ1FKdOnUd2oSqq2FsjIfwNTp05ieSMPEYbgiBAj2yno4M1yYsEZvZVMGnKFDRpUBPpGWmUeFUifCyhpqmHyjXs8fjOOZKHo3gTkYy5S1egjpMFFZuC8eKlJzjQFYHSm5GFDcmPDWgA6BuZizrQstsQtK9thcN7dsMrOB7jJ38HS1OSVXtbBAW+RR4FyNSB/GJddG5ZBxfOnMDVey9h5VgZtg7VMH3iSLx1uYWLV29CXc8ERrpK1KjTADmJsTCxr4WBneriwukTeOziSe3tYWBAONeqIxZcFGpaqEvyoq4QoK1vCHv2x6Qf+rSaYG9vCUNjC1RzsoVSXQMOZA/UVBVQ1zVCzerVUKV2I3Rv3wh3r1/GlZt3YGRpiwbkL7/7qisuH92Le8/cYOXgBKVCgfKXU5XKKEiPocQrGfVbtEbtSqZUPDuIS/fc0KXPQFQlHtcmH6oqLe9R9qlvZg17ilckVCipVq0mTPW1KB7QgBP5WMbNrnI1sgeW0FdXwfWrV/DM/Q069OyJRpQkCbnJOEu2v0hFG13atYS5XSXY2ZrD1NQctlbmpBYSkmsrmrstWnRsD0djgez0aQSFRoOEFRAgvrR0jTGIiqkRb5/h8NGTUCj1YG1thl4D+0OjJAU3yb/rkV01Ui+ErrUD8VYTEfFZGDSgOwK9X8DV8y2cHG2gIuShIC8XEZTQ2TnYI+qdPx48dEGxOErFWwUF/pECZHr/8eCvHSlMi8Z9UvbGbTuhhrMN9E30RAM6Zc4iLJw/FzPmLMDWLevQsH49fDP2O1gbakNHxwKTaN/SSBs1m3TApDFj4FyrIUaNHkpVajXUatQB3w7qBTWZgEEjJqNHm+akLL3ANwhNmzoVy9euw4RRgyjhkItolVCF4d27N0gtlGHwV/2hRysKWvrqqN2oORZO/x5qGjr4euwU8KUby9esx6rFC2BuYopvvpuE5XMno1Ov/li2chVmTJ+G5es2YtGM0RRcNsc335CyKVXQvENfDOvTFQq5AiPGzkTbhjXx2scNz73foXPPr2CoqQoDMztM/H4i7Iy0RZz4zbZqA2z5aRe+7tcNw4aNQN0qDhCkcvShAGvt2pWYPn0Gtm7fjYFd26JJs3bo06E5BZgStOjdH1/17YA6Tdtizdq1mD1rFubOmQJ7C12UyJUYN30JlixZgjEjiAZKVdSivksJ/yVLl2PFoukw0tGk5XIJegwchrnzFmLZojlUxTJF5XqtsHPnDvTt0h7DvxlJ/LJDm15DsWHjeixfsQY/bFgHc0MyPGOmYu3qFZg6bQa27diJHm3roVX7rlhGY85dsBjzpn5PTsMEnft9hVUrlmEeHZs8fjiMddWhpmMKC2NTSJkAtOnZVsFagl/dwZS+lf3XadUV82dMpoBhBDnXneCbQdeuXYOB3dqiXsvOWLB8CrTVZWWNxXcBFo7VMWr41zDQUBePgCxl9fpNsfHHTeKNo0uXLMPsSaPJcdXG4gULUKNWXYwaNwo62ppo0rEf5syahG79B9AqxxpMn0Z8XrUG40YOg2ON5lg6dzqqOFfHEKrCVKvXFNPnzaa5yFGlXkvMmjgOClUl+gz5FksWL8YK4se4kUOgRdVhvH8V0ypNvSYtMItovX79ajSt4wSn6nXx9TeDoU78Mbavhe9GDIeFmSm+nTwL61YuJ1lejn49O0CbEtMpsxZi+dJFIn3bN66FfKrAVqrbEjNnz8cGGq9F/aqoTE7nu2GDKOFTI+dXCaPHfY1atWtj9Q8bMGvGNCxYuAgrF86GoZ4uegybgBULZ2HIsKHY8MNa4uN0rFq5EuO/GQi7ynWwfO16LCQaLVkyl5ygJaydamDhoiVYTPxdtWIpajmYQ0Umhx0FzDK57P0sIdJj8cyJxBsNDB41HLWrOYjn9IwtsWjFKvTs2BBK0u0lP6xEJVtD8ZyKUgtTFq0kWg9A+05d8O03vcXj5W9teo/C8GE90bx5K3zVqwtUFXLUaNIOI6idsYU91m7ZJQbwjZu3xALCb978hVixfB6qOlqjDzlxDrakhGuLjr3Ro1trKChBa9ZlEAb06o5mHXuK/J46dTqWEX7jvu4DPX1jLF2zCRPGjcbXo8ajSV07OBKvFi1nnqzEGrIN9hTAtmzVkfSkHRQ0/8ade2Po4G5o0a4T0XMdpkydhpVUFRw/fCCq1W+FxXNmQFdTrXxKaNnza/Qn/ZXQkT5Dx6J/l3YUnFTDbJIPpvuatavRrEE11GnZEVMnDgUEAdVq1MO3g/tBg+SlUeev8FW/LhR+yDF65mx0blwJHXsNJB1dhulTp2Dd2o0YMZDm2+crDKVEtkHTTrTyOhhzFi3FoQN7ye7OI3sxA80b1UKDtl2xdv168P0Z82d+D2M9bZLNhli2cgWWr1qGPXt2oWurWvjwEjREm1Hb0RzaxlaYvWQ1FpE+zJo7H5s3roK9uREatuqKjWuJ3/2Hkm0aQ8GRFsnDWCxbtox0eQO+HdgdunoG+IoSgsa1nD+AhkQN4+bNR7sGtuIxPYK/bstWfDusG7r1HISaVZxgbFsN6zash7O1kdiG3xq2748Zk8egQZOWmDZhDNTkUj4sblXrtcGiaeOgpMSuUbuOmPJtHyjVdTHy+0lYSvisX7cBg7u3hTEFdQsWL8OE4QMgkwpiX+vKtbCK7P3M6VMxn3R79ZIZMCQ+lkpUMGbKVKxcswpjvukDVRpPrqqJr0eMwKJlKzB7xlhYWFth+JTxqOVsiw5dBxOP28Chah0sWb6a6D8f82dOQp1atTBr2XIsXTgHc+bOxUaCx8nHV8MnYfOm9cSDNZgzYxJMjbTRs99QdGjVFFUatsTq9etIFxdh4dypRG9DyJQaMKHCmoaqDOJLIkWtpi0wfEgPKFUVkJJf6kj0Wzz3e9So1xDTp0yEoYYCeqY22LR7D7Zs3og1ZEdWrlyGru2aQy6Vonb9Jvh6CNFKTUUEyW/NOvbF8GHdAYkMdai40btTexgam2HK3KVYtWI5Vq9eifbN6xJ9NTFx2lxMGP01jV/WX6mpiwHfjCE7tgSLl63C8oXzYGthjva0yrh+3VqazxJMHv8t9NSVaNauN9avX0UxQX18R/Zw9fIlWEK86kt6oqNnSknTMjhY6xH+9uTPFsBMU0Cl6g0w7Gv2dyqo37EbhvbrjAZN22PKyP4wN7fBCFo1NjHQgEWVxlgweyaMdPXx1YgxWLZ4oYjPCNItA10d9PlmHNZvWINVq9djzfJlMNDW4qmLm4l9DbRt5ICTJy5D19gC4yZPx+JFC7F61Vr07dwG1g41sHTeDOipiM0/vNVu0wfDvuoGuUQVU6eTfNdzgIGpFUaO+A6m9Dl4/FR0aNOQVuqGYuXSxZgzbwHGfjsY9lRwnLtgGRbPn0v2eBHaNGmALl99j0H92qFVq/boR/Rg+9OwQ0+yP10R4OuGxBJ1DB3SH8ZGejAy0RHjBUZEIpOjbrM2WLd+DRaRLG/6cQPaNa6NTiRXP27dQD5vOjZs2IRv+3eEtqE12eu1GPlVP8xYuBgrlszHnDlz8QPJXZOaDogL80d8hhQ1a1RHo7ZdyVYOhZwHqdgqKPAZCkg+c+xXD6kY2KBNiwa4cfY4XN4lY+miWdDXUIG6hiYMDAygTQrJm4IyeaVSKWbMEokU6mQ4pBIJ5ApqS8dlcgWUSjXynYJ4TKmmCgEQn3SjqqIAn9fV1aOqph40NTWpvxokArcAJATHqUoNqEsLyDhuQ66qJUaPHAo9DTVocIBJ7VRpDH19fejoaNMxDREPNaU6dHV0oFBRgbaOrghbS0sLWprqhIPiAz4KFVXRMAqEkVJdAwpyOEE+3lDo2mFU/w50FJBIeU7qIly8f0mkchpPF1oa6lCqKUm5ZeIZhqevbwBdXTqnrU3nVKEgOvA8BWqhUFWDmqoKwZRBh9owHRknhaoWunTuAjNDTRFXNaILNad2UsJfR6S3BtNVKkM1CoKqOjmBx9Gk8YkEkMoUNKYeuA3zQiaTlh3T04eenh60ae5MSxVVpXgdJNNGi/FTVYj019HVE8dQJz7xuMw7PaKpgYG+OAdBkKFtjyEY1LsLJNyANqlcAS2SAalEoG9l/8xLTU0N4q2SAgs9wlFf3DQIrpx4oUn0/6i52ElGuGtoaEDy0QkJzVNbpI8+tGkMDXV1yMhwalI7uVwOJdGC20uoL4+nQrB1aZ4sB8xndaUSMsKP28tkMsJHDXL6Xj4On2OYoBfzTI/oZEDzZT7RoQ//JlaV0LBJIxgZ6kGH8OAxZYSHkuYjCAIkJAdKGktC+yrEW+anHuGtkMvALzWlhkhvPXJoMqkEZhZ2aNKwHgwN9aGro4UyeDKisRoEQYCE5q1UV4OUZE5TS0fkiQ7xSZP0QiKRgPnH39VUVT/Qt6qnhWsAAAVQSURBVHy+Ap3X1NIW+2hraYJxEgSBlrR/PiYIAmxpZW8oBRTa6qoofzE9ymRJIFopISea8TlBEIjW6mC6CBIpwdIEz4PP8aZKesY8VSMd0NBQ8qEPG+OqVKqS/CtEmRcEASxXfExCsLS0daGtpQEZjaWlXTZXLVE+BKgSLXlMQADzR5V0hrrTvhrBUgXj+wt+E80k7+fPsq5UVxcTAkGQEM7aIk20SFdAL4VCheajgjJ4qlAjeySTyUV6sgxoka6oE0/lchVokrwxHamb+K8gvNQIF/6iqqYO3hdoXHVNLXEM5o1UIhHnqU44gV4ylle1Mv4qVNSg9j6QU2poQEUhE9vyXPQoIdQkPiuVauL8GbZIL6KtJuGk916++ZPPCSQjZTZEX9R7QRDAuDAtWQ8YF1WFnDAo/xfIPmoSb6XgySs1NEWcdclualPyLSebwePp6OqIPC/npwrNmW2BPo2vQnLNY6hTX5VPYKtraEBFTrDBLwEahLNSyfRVQiaTgXnGuiyVCNxA3PgYy50KybMWzV34+RS1VyH6q0OglgrSbw2CBWqgSvTg+emxnhHOEqI300ebZJ7bUnMIJF+a2mUyxXTQ0tSAoNBGO7KxttamEOeikENGslCHVjMrOdmJtBB9E8FTkqzICbYKzV2N+C18JEeMr4TmoFTXFPuItpTmqiDaMG467G/IlqgrVSEIAlSJ90wrgWBo0Tm2EZok54Ig0MqvM4YOHQIdDVVGW9zkCgXZA1UIQtls5AoF8U0dCsKVx+ajEpqfNsFiOvBctIh2UokE/BJpRbooCNySjwAK9nMk5/xNTnDUeE70hfWX8WHfKZVIxDHVibcMTxA+7q8GHotpzjohlUoglclJZ/TF4yLdqDnD1mW+EG1VVJUifbiPgmgj0Pw1CE8Z9ZVIpNDU1ICU+sjkcrI5ZfohJzwZN4ajTnogJRlXki5KiN7s43hsAYAK6RHjo6+vhzI7AdIjVcLFQPR3jL/kI/wlUjlGTJgMdSQiOjmHxlN/b5d1oSA+S6QyMGyJQMA/+hfxIboJECju0YAKzYNxZ5wYNzWyMyoKuUhfUUeI74y/IAhQEh2ZtrqkXzIaQ5XtBem+CsmyKm3UROzHtKvdoAk0SjPw4+YdkOnbYXDfLlBTyD5gwvixXLE/Zh1iPGRyFehRrMH2QIvkT53oJRCNNckHaJB/VFPXgIEBxyI64POM52vfILTt3huOVkZg/miyHH4YpWKnggK/pIDkl19/+5sgVcXgkROwe89e7NryA9o3qPHbHf6QswLMrB0xb9EK7Nq9G5vXLEU1W7M/ZCQGKlOoovtXI/DjhiUwNdTiQ3/KJlfXx8QJk1DZ7LfHlJKRaNWuK1rXrwbZ7+LmvzkNQQpDIyNoq8v/TUD/Xd0dazRC3wG9oan8z8zbsUpdDOnTg+io+pcRQqmuCR1yYoIg/GU4VAxcQYE/mwKC0gCjJk+Es43ph6FV1NTRbcAgWoW0+3Dsz9xR1dSFvq4GKjTxj6e6nqkjFsydCTM95R8/2O8cwcK2Mq16bRJjnFULZsHR0uR3Qviy5p36DUbvzi3xaWL0Zb0rWv2vUeB3h5iCIEBJGb4aVaJp9y+jl0wuhyZVJ7jq80cjIZMrIJfL/uhhRPg/vwngioXkC4gskUggkVS4GPwJL0EQiNa/W23way9BECCV/OfgoeJVQYEKCnwZBVj3qGItCL+0nWxPBeGXx74MYEWr/zYKKBQKsr9/T16XxTgaf2jsoVBRVCQL/21C+xfiWxGp/IXErxi6ggIVFPh/TYGKyVVQoIICFRSooEAFBf5fUOD/AAAA//+V5PESAAAABklEQVQDAACNPH6bwcZ5AAAAAElFTkSuQmCC\"\u003e\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eTable 2.\u003c/strong\u003e LncRNA Ontology of LncRNAs Altered in sAH and HCC+AUD\u003c/p\u003e\n\u003cdiv\u003e\n \u003ctable border=\"0\" cellspacing=\"0\" cellpadding=\"0\" width=\"472\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd valign=\"bottom\" style=\"width: 64.1949%;\"\u003e\n \u003cp\u003e\u003cstrong\u003eBiological Process\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 35.8051%;\"\u003e\n \u003cp\u003e\u003cstrong\u003eNumber of lncRNAs\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"bottom\" style=\"width: 64.1949%;\"\u003e\n \u003cp\u003emRNA splicing, via spliceosome\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.8051%;\"\u003e\n \u003cp\u003e23\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"bottom\" style=\"width: 64.1949%;\"\u003e\n \u003cp\u003eDNA repair\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 35.8051%;\"\u003e\n \u003cp\u003e21\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"bottom\" style=\"width: 64.1949%;\"\u003e\n \u003cp\u003eRNA processing\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 35.8051%;\"\u003e\n \u003cp\u003e19\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"bottom\" style=\"width: 64.1949%;\"\u003e\n \u003cp\u003emRNA processing\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd valign=\"bottom\" style=\"width: 35.8051%;\"\u003e\n \u003cp\u003e18\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd valign=\"bottom\" style=\"width: 64.1949%;\"\u003e\n \u003cp\u003eDNA metabolic process\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 35.8051%;\"\u003e\n \u003cp\u003e17\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n\u003c/div\u003e\n\u003cp\u003e\u003cstrong\u003eTable 3.\u003c/strong\u003e Oncogenes Affected in the Liver of Patients with Various Stages of Alcohol-induced Damage\u003c/p\u003e\n\u003cdiv style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\n \u003ctable style=\"border: none;width:368.0pt;border-collapse:collapse;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 132pt;border: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 18pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003eTranscript\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62pt;border-top: 1.5pt solid windowtext;border-left: none;border-bottom: 1.5pt solid windowtext;border-right: none;padding: 0cm 5.4pt;height: 18pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003eeASH\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;border-top: 1.5pt solid windowtext;border-left: none;border-bottom: 1.5pt solid windowtext;border-right: none;padding: 0cm 5.4pt;height: 18pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ensAH\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;border-top: 1.5pt solid windowtext;border-left: none;border-bottom: 1.5pt solid windowtext;border-right: none;padding: 0cm 5.4pt;height: 18pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003esAH\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;border-top: 1.5pt solid windowtext;border-right: 1.5pt solid windowtext;border-bottom: 1.5pt solid windowtext;border-image: initial;border-left: none;padding: 0cm 5.4pt;height: 18pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003eexAH\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 132pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;background: rgb(146, 208, 80);padding: 0cm 5.4pt;height: 17pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003eTP53\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 17pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 17pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 17pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 17pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 132pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;background: rgb(146, 208, 80);padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003eCTNNB1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 132pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;background: rgb(146, 208, 80);padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003eALB\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 132pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;background: rgb(146, 208, 80);padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003eAXIN1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 132pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;background: rgb(146, 208, 80);padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003eBAP1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 132pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;background: rgb(146, 208, 80);padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003eKEAP1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 132pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;background: rgb(146, 208, 80);padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003eNFE2L2\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 132pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;background: rgb(146, 208, 80);padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003eLZTR1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 132pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;background: rgb(146, 208, 80);padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003eRB1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 132pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;background: rgb(146, 208, 80);padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ePIK3CA\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 132pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;background: rgb(146, 208, 80);padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003eRPS6KA3\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 132pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;background: rgb(146, 208, 80);padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003eAZIN1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 132pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;background: rgb(146, 208, 80);padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003eKRAS\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 132pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;background: rgb(146, 208, 80);padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003eIL6ST\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 132pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;background: rgb(146, 208, 80);padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003eRP1L1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 58pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 132pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;background: rgb(146, 208, 80);padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003eCDKN2A\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 132pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;background: rgb(146, 208, 80);padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003eEEF1A1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 132pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;background: rgb(146, 208, 80);padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003eARID2\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 132pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;background: rgb(146, 208, 80);padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003eARID1A\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 132pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;background: rgb(146, 208, 80);padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003eGPATCH4\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 132pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;background: rgb(146, 208, 80);padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003eACVR2A\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 132pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;background: rgb(146, 208, 80);padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003eAPOB\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 132pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;background: rgb(146, 208, 80);padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003eCREB3L3\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 132pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;background: rgb(146, 208, 80);padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003eNRAS\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 132pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;background: rgb(146, 208, 80);padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003eAHCTF1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62pt;border-top: none;border-right: none;border-bottom: none;border-image: initial;border-left: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003ex\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;border-top: none;border-bottom: none;border-left: none;border-image: initial;border-right: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 16pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 132pt;border-top: none;border-left: 1.5pt solid windowtext;border-bottom: 1.5pt solid windowtext;border-right: none;background: rgb(146, 208, 80);padding: 0cm 5.4pt;height: 17pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003eHIST1H1C\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62pt;border-top: none;border-left: 1.5pt solid windowtext;border-bottom: 1.5pt solid windowtext;border-right: none;padding: 0cm 5.4pt;height: 17pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 17pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;border-top: none;border-right: none;border-left: none;border-image: initial;border-bottom: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 17pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;border-top: none;border-left: none;border-bottom: 1.5pt solid windowtext;border-right: 1.5pt solid windowtext;padding: 0cm 5.4pt;height: 17pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 132pt;padding: 0cm 5.4pt;height: 17pt;vertical-align: bottom;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"width: 62pt;padding: 0cm 5.4pt;height: 17pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e7\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 17pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e14\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 17pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e17\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 58pt;padding: 0cm 5.4pt;height: 17pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin:0cm;font-size:16px;font-family:\"Times New Roman\",serif;text-align:center;'\u003e\u003cspan style='font-family:\"Calibri\",sans-serif;color:black;'\u003e13\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n\u003c/div\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"scientific-reports","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"scirep","sideBox":"Learn more about [Scientific Reports](http://www.nature.com/srep/)","snPcode":"","submissionUrl":"","title":"Scientific Reports","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"Scientific Reports","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"alcohol use disorder, alcoholic liver disease, splicing, spliceosome, long non-coding RNA, hepatocellular carcinoma","lastPublishedDoi":"10.21203/rs.3.rs-7380649/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-7380649/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eAlcohol use disorder is a widespread illness commonly leading to alcoholic liver disease (ALD) and cirrhosis with an increased incidence of hepatocellular carcinoma (HCC), but the mechanisms of alcohol-related oncogenesis in the liver are incompletely understood. We tested the hypothesis that ALD predisposes to HCC via dysregulation of splicing. RNA sequencing was performed on liver biopsies from patients with different stages of ALD: early alcoholic steatohepatitis (eASH), non-severe alcoholic hepatitis (nsAH), and severe alcoholic hepatitis (sAH); furthermore, explants were collected from patients who underwent liver transplantation due to sAH (exAH). We found that alcohol caused widespread changes in transcriptome in all stages of ALD: among ~\u0026thinsp;58,000 analyzed genomic features, ~\u0026thinsp;4,900 were altered in eASH, ~\u0026thinsp;9,100 \u0026ndash; in nsAH, 14,100 \u0026ndash; in sAH, and ~\u0026thinsp;14,300 \u0026ndash; in exAH. We observed thousands of missplicing events in all hepatic conditions, with mutually exclusive exons (MEE) being the most common event and exon skipping (ES) \u0026ndash; second most common event. Analysis of ~\u0026thinsp;600,000 exons revealed that ALD is associated with a genome-wide effect on exon expression, with ~\u0026thinsp;50,000 exons being differentially expressed in eASH, ~\u0026thinsp;130,000 \u0026ndash; in nsAH, ~\u0026thinsp;150,000 \u0026ndash; in sAH, and ~\u0026thinsp;120,000 \u0026ndash; in exAH. To determine whether alcohol directly perturbs splicing, we subjected rats to alcohol vapor for 7 weeks and found that the expression of multiple snRNAs was drastically decreased, while expression of splicing factors was not affected. Screening of oncogenes and tumor suppressors, commonly involved in HCC pathogenesis, revealed that ALD affected the hepatic expression and/or splicing of most of these cancer-related genes. In summary, it appears that alcohol causes profound genome-wide changes in gene expression and splicing in the liver, likely via affecting the spliceosome. This results in altered expression and missplicing of key oncogenes and tumor suppressors involved in HCC, suggesting a novel mechanism of oncogenesis in the liver of patients with ALD.\u003c/p\u003e","manuscriptTitle":"Global Changes in Gene Expression and Splicing in Alcoholic Liver Disease","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-09-26 06:55:50","doi":"10.21203/rs.3.rs-7380649/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Revision requested","date":"2025-10-14T04:03:50+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2025-10-08T17:19:26+00:00","index":"hide","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2025-10-07T14:34:14+00:00","index":"hide","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2025-10-05T10:52:58+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"276802920978832820355685396219189619541","date":"2025-09-19T01:16:15+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"184754755105422745272616709295499845691","date":"2025-09-17T06:07:38+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"281922936143865502597683457921363237018","date":"2025-09-16T14:04:01+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"287388901956431132293005444570653869542","date":"2025-09-16T13:07:10+00:00","index":"hide","fulltext":""},{"type":"reviewersInvited","content":"","date":"2025-09-16T12:03:59+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2025-09-16T11:57:12+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2025-09-16T11:25:25+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2025-08-26T17:42:31+00:00","index":"","fulltext":""},{"type":"submitted","content":"Scientific Reports","date":"2025-08-26T17:37:58+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"scientific-reports","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"scirep","sideBox":"Learn more about [Scientific Reports](http://www.nature.com/srep/)","snPcode":"","submissionUrl":"","title":"Scientific Reports","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"Scientific Reports","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"0040d98a-daaa-4f2f-9793-13050ec135f8","owner":[],"postedDate":"September 26th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"under-review","subjectAreas":[{"id":55088947,"name":"Biological sciences/Cancer"},{"id":55088948,"name":"Health sciences/Diseases"},{"id":55088949,"name":"Health sciences/Gastroenterology"},{"id":55088950,"name":"Biological sciences/Genetics"},{"id":55088951,"name":"Biological sciences/Molecular biology"}],"tags":[],"updatedAt":"2026-05-07T08:12:30+00:00","versionOfRecord":[],"versionCreatedAt":"2025-09-26 06:55:50","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-7380649","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-7380649","identity":"rs-7380649","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}